SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_I_BEZI517_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 ILE A  45
GLU A  40
PHE A  69
ALA A  38
 None
 1.02A 1oniG-1a5cA:
undetectable
1oniI-1a5cA:
undetectable		 1oniG-1a5cA:
16.90
1oniI-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		4 ILE A 219
GLU A  40
PHE A 150
ALA A  36
 None
 1.11A 1oniG-1dqpA:
undetectable
1oniI-1dqpA:
undetectable		 1oniG-1dqpA:
18.47
1oniI-1dqpA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhe GLUTATHIONE
TRANSFERASE

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  70
PRO A  55
ARG A  17
ALA A  13
 None
 1.11A 1oniG-1fheA:
undetectable
1oniI-1fheA:
undetectable		 1oniG-1fheA:
20.67
1oniI-1fheA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ILE A 391
PRO A 500
PHE A 450
ALA A 396
 None
 0.91A 1oniG-1fuiA:
undetectable
1oniI-1fuiA:
undetectable		 1oniG-1fuiA:
13.54
1oniI-1fuiA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 TYR A 135
ILE A 115
PRO A 128
ARG A 131
 None
None
ADP  A1100 ( 4.6A)
ADP  A1100 ( 4.0A)
 1.11A 1oniG-1g8xA:
undetectable
1oniI-1g8xA:
undetectable		 1oniG-1g8xA:
8.62
1oniI-1g8xA:
8.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j7h HYPOTHETICAL PROTEIN
HI0719

(Haemophilus
influenzae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 116
GLU A 122
 None
 0.56A 1oniG-1j7hA:
18.8
1oniI-1j7hA:
18.8		 1oniG-1j7hA:
42.96
1oniI-1j7hA:
42.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd1 HYPOTHETICAL 13.9
KDA PROTEIN IN
FCY2-PET117
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 114
GLU A 120
 None
 0.39A 1oniG-1jd1A:
23.1
1oniI-1jd1A:
22.7		 1oniG-1jd1A:
38.64
1oniI-1jd1A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 PRO A 527
PHE A 529
ARG A  74
ALA A 212
 None
 1.03A 1oniG-1m22A:
undetectable
1oniI-1m22A:
undetectable		 1oniG-1m22A:
16.85
1oniI-1m22A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ILE A 150
PRO A 149
ARG A 141
ALA A 145
 None
 1.10A 1oniG-1odoA:
undetectable
1oniI-1odoA:
undetectable		 1oniG-1odoA:
19.55
1oniI-1odoA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oni 14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN

(Homo sapiens) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  21
ILE A  37
PRO A 116
GLU A 122
 None
 0.45A 1oniG-1oniA:
26.3
1oniI-1oniA:
27.3		 1oniG-1oniA:
100.00
1oniI-1oniA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 115
GLU A 121
 None
 0.21A 1oniG-1qahA:
26.4
1oniI-1qahA:
25.9		 1oniG-1qahA:
87.50
1oniI-1qahA:
87.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		4 ILE A 322
PRO A 274
GLU A 323
PHE A 241
 None
 1.05A 1oniG-1qd1A:
2.5
1oniI-1qd1A:
undetectable		 1oniG-1qd1A:
19.94
1oniI-1qd1A:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qd9 PURINE REGULATORY
PROTEIN YABJ

(Bacillus
subtilis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 111
GLU A 117
 None
 0.54A 1oniG-1qd9A:
23.2
1oniI-1qd9A:
23.2		 1oniG-1qd9A:
42.22
1oniI-1qd9A:
42.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.44A 1oniG-1qu9A:
21.8
1oniI-1qu9A:
21.9		 1oniG-1qu9A:
44.78
1oniI-1qu9A:
44.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 1

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 TYR A 305
ILE A 340
GLU A 355
ALA A 308
 None
None
MG  A1095 (-2.8A)
None
 1.11A 1oniG-1tqyA:
undetectable
1oniI-1tqyA:
undetectable		 1oniG-1tqyA:
15.49
1oniI-1tqyA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjk MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1

(Pyrococcus
furiosus) 		PF02597
(ThiS) 		4 ILE A  23
GLU A  21
PHE A  45
ALA A  16
 None
 1.10A 1oniG-1vjkA:
undetectable
1oniI-1vjkA:
undetectable		 1oniG-1vjkA:
21.09
1oniI-1vjkA:
21.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811

(Sulfurisphaera
tokodaii) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.49A 1oniG-1x25A:
24.0
1oniI-1x25A:
24.0		 1oniG-1x25A:
43.61
1oniI-1x25A:
43.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 TYR A 232
ILE A 148
PHE A 106
ALA A 202
 None
None
MRY  A1890 (-3.7A)
None
 1.12A 1oniG-1xpgA:
undetectable
1oniI-1xpgA:
undetectable		 1oniG-1xpgA:
11.99
1oniI-1xpgA:
11.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY

(Ruminiclostridium
thermocellum) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.47A 1oniG-1xrgA:
23.8
1oniI-1xrgA:
23.8		 1oniG-1xrgA:
44.52
1oniI-1xrgA:
44.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 TYR B 454
ILE B 378
PHE B 494
ALA B 479
 None
 1.06A 1oniG-2a1aB:
undetectable
1oniI-2a1aB:
undetectable		 1oniG-2a1aB:
18.28
1oniI-2a1aB:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 PRO A 357
GLU A 325
PHE A 197
ALA A 360
 None
 1.11A 1oniG-2abjA:
undetectable
1oniI-2abjA:
undetectable		 1oniG-2abjA:
20.86
1oniI-2abjA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b33 PROTEIN SYNTHESIS
INHIBITOR, PUTATIVE

(Thermotoga
maritima) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 112
GLU A 118
 None
 0.45A 1oniG-2b33A:
23.0
1oniI-2b33A:
23.3		 1oniG-2b33A:
42.14
1oniI-2b33A:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cwj PUTATIVE
ENDONUCLEASE

(Aeropyrum
pernix) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  11
ILE A  27
PRO A 106
GLU A 112
 None
 0.77A 1oniG-2cwjA:
19.3
1oniI-2cwjA:
19.2		 1oniG-2cwjA:
39.86
1oniI-2cwjA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2etv IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDING
PROTEIN, PUTATIVE

(Thermotoga
maritima) 		PF01497
(Peripla_BP_2) 		4 ILE A 302
PRO A 214
PHE A 144
ALA A 295
 None
 0.93A 1oniG-2etvA:
undetectable
1oniI-2etvA:
undetectable		 1oniG-2etvA:
18.81
1oniI-2etvA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B

(Archaeoglobus
fulgidus;
Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9) 		4 ILE B 724
PRO B 726
PHE A 238
ALA A  67
 None
 1.11A 1oniG-2fjaB:
undetectable
1oniI-2fjaB:
undetectable		 1oniG-2fjaB:
19.38
1oniI-2fjaB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
ALPHA-CHAIN,
MITOCHONDRIAL
SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa;
Sus scrofa) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		4 ILE A 218
GLU A 217
PHE B 293
ALA B 273
 None
None
None
PO4  A 401 (-3.8A)
 1.05A 1oniG-2fpgA:
undetectable
1oniI-2fpgA:
undetectable		 1oniG-2fpgA:
22.35
1oniI-2fpgA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 218
PRO A 156
GLU A 217
ARG A 213
 None
None
None
SO4  A 410 (-3.0A)
 0.96A 1oniG-2g17A:
undetectable
1oniI-2g17A:
undetectable		 1oniG-2g17A:
19.53
1oniI-2g17A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		4 TYR A  48
PRO A  26
GLU A  45
PHE A  29
 None
 1.08A 1oniG-2hcuA:
undetectable
1oniI-2hcuA:
undetectable		 1oniG-2hcuA:
20.85
1oniI-2hcuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		4 TYR A 267
PRO A 248
PHE A 252
ALA A 208
 None
 1.10A 1oniG-2hi1A:
2.7
1oniI-2hi1A:
undetectable		 1oniG-2hi1A:
18.77
1oniI-2hi1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iod DIHYDROFLAVONOL
4-REDUCTASE

(Vitis vinifera) 		PF01370
(Epimerase) 		4 ILE A 213
PRO A 212
PHE A 280
ALA A 264
 None
 1.12A 1oniG-2iodA:
undetectable
1oniI-2iodA:
undetectable		 1oniG-2iodA:
16.08
1oniI-2iodA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 139
PRO A 141
GLU A 163
PHE A 145
 None
 1.01A 1oniG-2j66A:
undetectable
1oniI-2j66A:
undetectable		 1oniG-2j66A:
16.46
1oniI-2j66A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2
SEPTIN-6

(Homo sapiens;
Homo sapiens) 		PF00735
(Septin)
PF00735
(Septin) 		4 ILE B 183
PRO B 157
PHE A 156
ALA B 188
 None
 0.81A 1oniG-2qagB:
undetectable
1oniI-2qagB:
undetectable		 1oniG-2qagB:
15.28
1oniI-2qagB:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		4 ILE A  70
PRO A  90
ARG A  28
ALA A  41
 None
 0.92A 1oniG-2qp2A:
undetectable
1oniI-2qp2A:
undetectable		 1oniG-2qp2A:
21.99
1oniI-2qp2A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.23A 1oniG-2uykA:
22.3
1oniI-2uykA:
22.2		 1oniG-2uykA:
39.01
1oniI-2uykA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 0.77A 1oniG-3b8oA:
undetectable
1oniI-3b8oA:
undetectable		 1oniG-3b8oA:
20.46
1oniI-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		4 TYR A 122
ILE A 181
PHE A  95
ALA A  92
 None
 1.06A 1oniG-3bc1A:
undetectable
1oniI-3bc1A:
undetectable		 1oniG-3bc1A:
22.50
1oniI-3bc1A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		4 TYR A 368
ILE A 417
PHE A 363
ALA A 196
 None
 1.09A 1oniG-3bzmA:
undetectable
1oniI-3bzmA:
undetectable		 1oniG-3bzmA:
15.94
1oniI-3bzmA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 ILE A 193
GLU A 189
ARG A 222
ALA A 503
 None
 1.10A 1oniG-3do6A:
undetectable
1oniI-3do6A:
undetectable		 1oniG-3do6A:
14.81
1oniI-3do6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmy HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA
(YGIT/B3021)

(Escherichia
coli) 		PF15731
(MqsA_antitoxin) 		4 ILE A  74
PRO A 109
ARG A 101
ALA A 107
 None
MEQ  A 108 ( 2.6A)
None
MEQ  A 108 ( 3.1A)
 0.87A 1oniG-3fmyA:
undetectable
1oniI-3fmyA:
undetectable		 1oniG-3fmyA:
20.14
1oniI-3fmyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		4 ILE A 108
PRO A 129
ARG A 137
ALA A 133
 None
 1.12A 1oniG-3gnlA:
undetectable
1oniI-3gnlA:
undetectable		 1oniG-3gnlA:
20.08
1oniI-3gnlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 TYR A 223
ILE A 184
PRO A 163
ALA A 218
 None
 0.91A 1oniG-3gs6A:
undetectable
1oniI-3gs6A:
undetectable		 1oniG-3gs6A:
18.24
1oniI-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		4 TYR A 186
ILE A 183
PHE A 198
ALA A 164
 None
 0.98A 1oniG-3iiwA:
undetectable
1oniI-3iiwA:
undetectable		 1oniG-3iiwA:
16.21
1oniI-3iiwA:
16.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k0t ENDORIBONUCLEASE
L-PSP, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 112
GLU A 118
 BGC  A 127 (-3.1A)
BGC  A 127 (-4.0A)
None
BGC  A 127 (-3.5A)
 0.63A 1oniG-3k0tA:
23.1
1oniI-3k0tA:
23.0		 1oniG-3k0tA:
40.94
1oniI-3k0tA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 ILE A  37
GLU A  32
PHE A  61
ALA A  30
 None
 0.92A 1oniG-3kx6A:
undetectable
1oniI-3kx6A:
undetectable		 1oniG-3kx6A:
20.11
1oniI-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A 262
GLU A 271
PHE A 412
ALA A 351
 None
 1.05A 1oniG-3l22A:
undetectable
1oniI-3l22A:
undetectable		 1oniG-3l22A:
18.80
1oniI-3l22A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 ILE A 279
GLU A 276
PHE A 269
ALA A 303
 None
 1.10A 1oniG-3ll7A:
undetectable
1oniI-3ll7A:
undetectable		 1oniG-3ll7A:
16.63
1oniI-3ll7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 ILE A  29
GLU A  24
PHE A  53
ALA A  22
 None
2FP  A 350 ( 4.9A)
None
None
 0.98A 1oniG-3mmtA:
undetectable
1oniI-3mmtA:
undetectable		 1oniG-3mmtA:
19.88
1oniI-3mmtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis) 		PF09754
(PAC2) 		4 ILE A  98
PRO A  75
PHE A  56
ALA A  50
 None
 1.09A 1oniG-3mnfA:
undetectable
1oniI-3mnfA:
undetectable		 1oniG-3mnfA:
21.63
1oniI-3mnfA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mqw PUTATIVE
ENDORIBONUCLEASE
L-PSP

(Entamoeba
histolytica) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 FLC  A 140 (-4.0A)
FLC  A 140 (-4.8A)
FLC  A 140 (-4.5A)
FLC  A 140 (-2.8A)
 0.46A 1oniG-3mqwA:
22.8
1oniI-3mqwA:
23.0		 1oniG-3mqwA:
42.75
1oniI-3mqwA:
42.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 TYR A 303
ILE A 256
ARG A 383
ALA A 385
 None
None
014  A 417 (-3.1A)
014  A 417 ( 3.9A)
 1.00A 1oniG-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniG-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oui EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 TYR A 303
ILE A 256
ARG A 383
ALA A 385
 None
None
42Z  A 393 (-2.9A)
42Z  A 393 ( 4.3A)
 0.94A 1oniG-3ouiA:
undetectable
1oniI-3ouiA:
undetectable		 1oniG-3ouiA:
21.23
1oniI-3ouiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ILE A 251
GLU A 261
PHE A 471
ALA A 416
 None
 1.02A 1oniG-3qnkA:
undetectable
1oniI-3qnkA:
undetectable		 1oniG-3qnkA:
14.86
1oniI-3qnkA:
14.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quw PROTEIN MMF1

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  36
ILE A  52
PRO A 130
GLU A 136
 None
 0.41A 1oniG-3quwA:
22.5
1oniI-3quwA:
22.4		 1oniG-3quwA:
32.68
1oniI-3quwA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0p L-PSP PUTATIVE
ENDORIBONUCLEASE

(uncultured
organism) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 None
 0.57A 1oniG-3r0pA:
23.3
1oniI-3r0pA:
23.4		 1oniG-3r0pA:
43.18
1oniI-3r0pA:
43.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 ILE B 553
PRO B 435
PHE B 437
ALA B 548
 None
 0.63A 1oniG-3u9rB:
undetectable
1oniI-3u9rB:
undetectable		 1oniG-3u9rB:
13.65
1oniI-3u9rB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 ILE A 845
PRO A 839
PHE A 836
ALA A 864
 None
 1.10A 1oniG-3uatA:
undetectable
1oniI-3uatA:
undetectable		 1oniG-3uatA:
20.27
1oniI-3uatA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 ILE A 121
PRO A 118
PHE A  77
ALA A 146
 None
None
URE  A 904 (-4.6A)
None
 0.94A 1oniG-3umvA:
undetectable
1oniI-3umvA:
undetectable		 1oniG-3umvA:
16.89
1oniI-3umvA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vcz ENDORIBONUCLEASE
L-PSP

(Vibrio
vulnificus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 115
GLU A 121
 None
 0.39A 1oniG-3vczA:
21.4
1oniI-3vczA:
21.5		 1oniG-3vczA:
37.01
1oniI-3vczA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aah METHANOL
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF13360
(PQQ_2) 		4 ILE A 508
PRO A 532
PHE A 553
ALA A 465
 None
 1.10A 1oniG-4aahA:
undetectable
1oniI-4aahA:
undetectable		 1oniG-4aahA:
13.39
1oniI-4aahA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		4 TYR A 766
PRO A 681
PHE A 683
ALA A 675
 None
 0.83A 1oniG-4aioA:
undetectable
1oniI-4aioA:
undetectable		 1oniG-4aioA:
10.25
1oniI-4aioA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bn5 NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL

(Homo sapiens) 		PF02146
(SIR2) 		4 ILE A 268
PRO A 289
PHE A 192
ALA A 196
 None
 1.11A 1oniG-4bn5A:
undetectable
1oniI-4bn5A:
undetectable		 1oniG-4bn5A:
19.35
1oniI-4bn5A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 ILE A 110
GLU A 105
PHE A 134
ALA A 103
 None
 0.83A 1oniG-4d2jA:
undetectable
1oniI-4d2jA:
undetectable		 1oniG-4d2jA:
17.75
1oniI-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egw MAGNESIUM TRANSPORT
PROTEIN CORA

(Methanocaldococcus
jannaschii) 		PF01544
(CorA) 		4 ILE A 143
PRO A  81
PHE A  83
ARG A 149
 None
 1.05A 1oniG-4egwA:
undetectable
1oniI-4egwA:
undetectable		 1oniG-4egwA:
19.86
1oniI-4egwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ILE W 471
PRO W 435
GLU W 390
ARG W 814
 None
 0.99A 1oniG-4f5xW:
undetectable
1oniI-4f5xW:
undetectable		 1oniG-4f5xW:
8.95
1oniI-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		4 TYR A 154
ILE A 137
PHE A 174
ALA A 157
 None
 1.11A 1oniG-4fn7A:
undetectable
1oniI-4fn7A:
undetectable		 1oniG-4fn7A:
23.81
1oniI-4fn7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		4 TYR A 229
ILE A 189
PRO A 166
ALA A 224
 None
 1.00A 1oniG-4gvfA:
undetectable
1oniI-4gvfA:
undetectable		 1oniG-4gvfA:
15.34
1oniI-4gvfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkx HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 TYR E 195
ILE E 217
PRO E 215
ALA E 200
 None
 1.09A 1oniG-4hkxE:
undetectable
1oniI-4hkxE:
undetectable		 1oniG-4hkxE:
20.39
1oniI-4hkxE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 TYR A 458
ILE A 382
PHE A 451
ALA A 465
 None
 1.06A 1oniG-4k0eA:
undetectable
1oniI-4k0eA:
undetectable		 1oniG-4k0eA:
9.30
1oniI-4k0eA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4klz GTP-BINDING PROTEIN
RIT1

(Homo sapiens) 		PF00071
(Ras) 		4 PRO A 159
GLU A 181
PHE A 161
ALA A 177
 None
 0.94A 1oniG-4klzA:
undetectable
1oniI-4klzA:
undetectable		 1oniG-4klzA:
23.12
1oniI-4klzA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lyp EXO-BETA-1,4-MANNOSI
DASE

(Rhizomucor
miehei) 		no annotation 4 TYR A 319
PRO A 266
GLU A 259
ALA A 305
 None
 1.12A 1oniG-4lypA:
undetectable
1oniI-4lypA:
undetectable		 1oniG-4lypA:
16.19
1oniI-4lypA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		4 ILE A 107
PHE A  37
ARG A 251
ALA A 247
 None
 1.10A 1oniG-4mydA:
undetectable
1oniI-4mydA:
undetectable		 1oniG-4mydA:
20.92
1oniI-4mydA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		4 ILE A 172
PRO A  94
ARG A 107
ALA A 106
 None
 1.05A 1oniG-4n30A:
undetectable
1oniI-4n30A:
undetectable		 1oniG-4n30A:
17.89
1oniI-4n30A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 ILE B  99
GLU B 221
PHE B 109
ALA B 118
 None
 0.99A 1oniG-4o9uB:
undetectable
1oniI-4o9uB:
undetectable		 1oniG-4o9uB:
16.92
1oniI-4o9uB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 TYR A2086
ILE A1784
GLU A1798
ALA A2064
 None
 1.06A 1oniG-4o9xA:
undetectable
1oniI-4o9xA:
undetectable		 1oniG-4o9xA:
5.07
1oniI-4o9xA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 TYR A 212
ILE A 181
PRO A 172
ALA A 200
 None
 1.03A 1oniG-4qawA:
2.2
1oniI-4qawA:
undetectable		 1oniG-4qawA:
14.77
1oniI-4qawA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		4 TYR A 389
PRO A 204
GLU A 337
PHE A 459
 None
 1.10A 1oniG-4rmlA:
undetectable
1oniI-4rmlA:
undetectable		 1oniG-4rmlA:
18.01
1oniI-4rmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN

(Haliangium
ochraceum) 		PF14497
(GST_C_3) 		4 ILE A  71
PRO A  56
ARG A  20
ALA A  16
 None
 1.09A 1oniG-4w66A:
undetectable
1oniI-4w66A:
undetectable		 1oniG-4w66A:
21.49
1oniI-4w66A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsp PROTEIN DL-RV1738

(Mycobacterium
tuberculosis) 		PF08962
(DUF1876) 		4 ILE A  57
PRO A  49
ARG A  65
ALA A  45
 None
None
CL  A 101 ( 3.5A)
CL  A 101 ( 4.0A)
 1.03A 1oniG-4wspA:
undetectable
1oniI-4wspA:
undetectable		 1oniG-4wspA:
26.09
1oniI-4wspA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum) 		PF00252
(Ribosomal_L16) 		4 ILE F  65
PRO F  93
ARG F  32
ALA F  29
 None
None
U  N1222 ( 3.3A)
None
 0.92A 1oniG-5anbF:
undetectable
1oniI-5anbF:
undetectable		 1oniG-5anbF:
20.91
1oniI-5anbF:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		4 ILE A 512
PRO A 508
GLU A 455
PHE A 267
 None
 1.07A 1oniG-5bp8A:
undetectable
1oniI-5bp8A:
undetectable		 1oniG-5bp8A:
15.37
1oniI-5bp8A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		4 TYR A 346
ILE A 373
PHE A 319
ALA A 349
 None
 1.06A 1oniG-5ch6A:
undetectable
1oniI-5ch6A:
undetectable		 1oniG-5ch6A:
19.86
1oniI-5ch6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA) 		4 ILE A 236
PRO A  21
ARG A 261
ALA A  45
 None
 1.08A 1oniG-5ey5A:
undetectable
1oniI-5ey5A:
undetectable		 1oniG-5ey5A:
22.75
1oniI-5ey5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5o NUCLEOPROTEIN

(Marburg
marburgvirus) 		PF05505
(Ebola_NP) 		4 ILE A 191
PHE A  72
ARG A  82
ALA A  78
 None
 1.11A 1oniG-5f5oA:
undetectable
1oniI-5f5oA:
undetectable		 1oniG-5f5oA:
18.09
1oniI-5f5oA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron;
Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2)
PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ILE B 614
PRO A 235
PHE A 226
ALA A  31
 None
 0.75A 1oniG-5fq6B:
undetectable
1oniI-5fq6B:
undetectable		 1oniG-5fq6B:
10.58
1oniI-5fq6B:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 ILE A  68
PRO A  84
GLU A  64
ALA A 151
 None
 1.12A 1oniG-5h8wA:
undetectable
1oniI-5h8wA:
undetectable		 1oniG-5h8wA:
15.15
1oniI-5h8wA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF00008
(EGF) 		4 ILE A  57
PRO A  55
ARG C  22
ALA C  31
 None
 0.86A 1oniG-5kn5A:
undetectable
1oniI-5kn5A:
undetectable		 1oniG-5kn5A:
24.06
1oniI-5kn5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A1158
PHE A1203
ARG A1177
ALA A1173
 None
 1.05A 1oniG-5m3cA:
undetectable
1oniI-5m3cA:
undetectable		 1oniG-5m3cA:
undetectable
1oniI-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ILE B 337
PRO B 352
GLU B 342
ALA B 346
 None
 1.06A 1oniG-5n8nB:
undetectable
1oniI-5n8nB:
undetectable		 1oniG-5n8nB:
undetectable
1oniI-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 ILE A 248
PRO A 246
PHE A 220
ALA A 452
 None
 0.89A 1oniG-5nlmA:
undetectable
1oniI-5nlmA:
undetectable		 1oniG-5nlmA:
undetectable
1oniI-5nlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 4 ILE A 391
PRO A 388
GLU A 361
ALA A 358
 None
 1.10A 1oniG-5odsA:
undetectable
1oniI-5odsA:
undetectable		 1oniG-5odsA:
undetectable
1oniI-5odsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 ILE B  99
GLU B 221
PHE B 109
ALA B 118
 None
None
BEN  B 310 ( 4.2A)
None
 1.01A 1oniG-5uniB:
undetectable
1oniI-5uniB:
undetectable		 1oniG-5uniB:
19.17
1oniI-5uniB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 ILE A 343
PRO A 348
PHE A 350
ALA A 336
 None
 1.03A 1oniG-5ur2A:
undetectable
1oniI-5ur2A:
undetectable		 1oniG-5ur2A:
10.16
1oniI-5ur2A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 ILE A 807
PRO A 857
PHE A 844
ALA A 802
 None
 1.08A 1oniG-5ur2A:
undetectable
1oniI-5ur2A:
undetectable		 1oniG-5ur2A:
10.16
1oniI-5ur2A:
10.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v4d PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 113
GLU A 119
 None
 0.35A 1oniG-5v4dA:
24.2
1oniI-5v4dA:
23.8		 1oniG-5v4dA:
45.38
1oniI-5v4dA:
45.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vad BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF03129
(HGTP_anticodon)
PF09180
(ProRS-C_1) 		4 TYR A1127
ILE A1142
PHE A1078
ALA A1129
 None
 1.07A 1oniG-5vadA:
undetectable
1oniI-5vadA:
undetectable		 1oniG-5vadA:
15.48
1oniI-5vadA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvh OCTOPINE
CATABOLISM/UPTAKE
OPERON REGULATORY
PROTEIN OCCR

(Agrobacterium
tumefaciens) 		PF03466
(LysR_substrate) 		4 ILE A 210
PRO A 182
PHE A 254
ALA A 206
 None
 1.08A 1oniG-5vvhA:
undetectable
1oniI-5vvhA:
undetectable		 1oniG-5vvhA:
22.86
1oniI-5vvhA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w4x UDP-GLUCOSE
6-DEHYDROGENASE

(Homo sapiens) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ILE A  52
PRO A  18
GLU A  54
ALA A 168
 None
 1.12A 1oniG-5w4xA:
undetectable
1oniI-5w4xA:
undetectable		 1oniG-5w4xA:
14.77
1oniI-5w4xA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 4 TYR A 422
ILE A 241
PHE A 414
ALA A 375
 None
 1.10A 1oniG-5y31A:
undetectable
1oniI-5y31A:
undetectable		 1oniG-5y31A:
undetectable
1oniI-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 4 TYR A 266
PRO A 247
PHE A 251
ALA A 207
 None
None
FMT  A 402 (-4.8A)
None
 1.05A 1oniG-6e85A:
2.5
1oniI-6e85A:
undetectable		 1oniG-6e85A:
undetectable
1oniI-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 4 ILE A 495
PRO A 430
PHE A 353
ALA A 363
 None
 1.12A 1oniG-6gngA:
undetectable
1oniI-6gngA:
undetectable		 1oniG-6gngA:
undetectable
1oniI-6gngA:
undetectable