SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_H_BEZH515_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 PHE A 271
ARG A 358
TYR A 357
ILE A 414
 None
 1.19A 1oniH-1b8aA:
0.0
1oniI-1b8aA:
0.0		 1oniH-1b8aA:
14.55
1oniI-1b8aA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 PHE A  14
ALA A  27
ILE A 218
PRO A  11
 None
 1.00A 1oniH-1dppA:
0.0
1oniI-1dppA:
0.0		 1oniH-1dppA:
14.26
1oniI-1dppA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA
MATURE CAPSID
PROTEIN GAMMA

(Pariacoto
virus;
Pariacoto virus) 		PF01829
(Peptidase_A6)
no annotation 		4 ALA A 341
TYR D 400
ILE A  77
PRO A  78
 None
 1.17A 1oniH-1f8vA:
0.0
1oniI-1f8vA:
0.0		 1oniH-1f8vA:
18.46
1oniI-1f8vA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 PHE A 450
ALA A 396
ILE A 391
PRO A 500
 None
 1.10A 1oniH-1fuiA:
undetectable
1oniI-1fuiA:
undetectable		 1oniH-1fuiA:
13.54
1oniI-1fuiA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ARG A 131
TYR A 135
ILE A 115
PRO A 128
 ADP  A1100 ( 4.0A)
None
None
ADP  A1100 ( 4.6A)
 1.12A 1oniH-1g8xA:
undetectable
1oniI-1g8xA:
undetectable		 1oniH-1g8xA:
8.62
1oniI-1g8xA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h04 COMPLEMENT
DECAY-ACCELERATING
FACTOR

(Homo sapiens) 		PF00084
(Sushi) 		4 ARG P  65
ALA P  41
ILE P  13
PRO P  62
 None
 1.21A 1oniH-1h04P:
undetectable
1oniI-1h04P:
undetectable		 1oniH-1h04P:
21.15
1oniI-1h04P:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 PHE A 333
ALA A 364
ILE A 409
PRO A 501
 None
 0.96A 1oniH-1m64A:
undetectable
1oniI-1m64A:
undetectable		 1oniH-1m64A:
17.90
1oniI-1m64A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mdf 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Bacillus
subtilis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 PHE A  96
ALA A 185
TYR A 207
PRO A 102
 None
 1.15A 1oniH-1mdfA:
undetectable
1oniI-1mdfA:
undetectable		 1oniH-1mdfA:
13.46
1oniI-1mdfA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mmf GLYCEROL DEHYDRASE
BETA SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU) 		4 ARG B  70
ALA B  21
ILE B  74
PRO B 184
 None
 1.18A 1oniH-1mmfB:
undetectable
1oniI-1mmfB:
undetectable		 1oniH-1mmfB:
20.41
1oniI-1mmfB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		4 PHE D 671
ARG D 638
ALA D 640
ILE D 730
 None
 0.88A 1oniH-1o7dD:
undetectable
1oniI-1o7dD:
undetectable		 1oniH-1o7dD:
18.28
1oniI-1o7dD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ARG A 141
ALA A 145
ILE A 150
PRO A 149
 None
 1.03A 1oniH-1odoA:
undetectable
1oniI-1odoA:
undetectable		 1oniH-1odoA:
19.55
1oniI-1odoA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pem RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
ALPHA CHAIN

(Salmonella
enterica) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF08343
(RNR_N) 		4 PHE A 667
ALA A 679
ILE A 646
PRO A 643
 None
 1.20A 1oniH-1pemA:
0.7
1oniI-1pemA:
undetectable		 1oniH-1pemA:
11.90
1oniI-1pemA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 PHE A 336
ALA A 291
ILE A 403
PRO A 417
 None
None
BTB  A1301 ( 4.9A)
None
 1.20A 1oniH-1vclA:
undetectable
1oniI-1vclA:
undetectable		 1oniH-1vclA:
18.44
1oniI-1vclA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		4 ARG A 148
ALA A  20
ILE A  64
PRO A  71
 None
 1.03A 1oniH-1vzvA:
undetectable
1oniI-1vzvA:
undetectable		 1oniH-1vzvA:
23.38
1oniI-1vzvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 PHE J  82
ALA J  70
ILE J 237
PRO J 304
 None
 1.04A 1oniH-1wcdJ:
undetectable
1oniI-1wcdJ:
undetectable		 1oniH-1wcdJ:
18.18
1oniI-1wcdJ:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0m AMINOTRANSFERASE II
HOMOLOGUE

(Pyrococcus
horikoshii) 		PF00155
(Aminotran_1_2) 		4 PHE A 100
ALA A  91
TYR A  87
ILE A  79
 None
 1.22A 1oniH-1x0mA:
undetectable
1oniI-1x0mA:
undetectable		 1oniH-1x0mA:
13.68
1oniI-1x0mA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		4 ALA A 783
TYR A 774
ILE A 792
PRO A 787
 None
 1.13A 1oniH-2b3xA:
undetectable
1oniI-2b3xA:
undetectable		 1oniH-2b3xA:
10.84
1oniI-2b3xA:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 PHE H 491
ARG H 515
ALA H 514
PRO H 484
 None
 1.02A 1oniH-2fhgH:
undetectable
1oniI-2fhgH:
undetectable		 1oniH-2fhgH:
23.01
1oniI-2fhgH:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 181
TYR A 405
ILE A 170
PRO A 172
 None
 1.08A 1oniH-2fymA:
undetectable
1oniI-2fymA:
undetectable		 1oniH-2fymA:
17.80
1oniI-2fymA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gb3 ASPARTATE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00155
(Aminotran_1_2) 		4 PHE A 209
ALA A 316
ILE A 319
PRO A 313
 None
 1.08A 1oniH-2gb3A:
undetectable
1oniI-2gb3A:
undetectable		 1oniH-2gb3A:
15.22
1oniI-2gb3A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx6 RIBONUCLEASE

(Escherichia
virus T4) 		PF10715
(REGB_T4) 		4 PHE A  64
ALA A 134
TYR A  45
ILE A  54
 None
 1.09A 1oniH-2hx6A:
undetectable
1oniI-2hx6A:
undetectable		 1oniH-2hx6A:
25.14
1oniI-2hx6A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		4 PHE A 515
ALA A 388
TYR A 460
ILE A 395
 None
 1.09A 1oniH-2nvoA:
undetectable
1oniI-2nvoA:
undetectable		 1oniH-2nvoA:
14.77
1oniI-2nvoA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		4 PHE A 593
ALA A 259
ILE A 563
PRO A 595
 None
 1.11A 1oniH-2o5pA:
undetectable
1oniI-2o5pA:
undetectable		 1oniH-2o5pA:
11.04
1oniI-2o5pA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 ALA A  51
TYR A  62
ILE A 267
PRO A 153
 None
 1.18A 1oniH-2p3xA:
undetectable
1oniI-2p3xA:
undetectable		 1oniH-2p3xA:
16.96
1oniI-2p3xA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 184
TYR A 403
ILE A 173
PRO A 175
 None
 1.05A 1oniH-2pa6A:
undetectable
1oniI-2pa6A:
undetectable		 1oniH-2pa6A:
17.28
1oniI-2pa6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbl PUTATIVE
ESTERASE/LIPASE/THIO
ESTERASE

(Ruegeria sp.
TM1040) 		PF07859
(Abhydrolase_3) 		4 PHE A  52
ALA A  96
ILE A 115
PRO A  98
 None
 1.19A 1oniH-2pblA:
0.9
1oniI-2pblA:
1.6		 1oniH-2pblA:
21.07
1oniI-2pblA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2
SEPTIN-6

(Homo sapiens;
Homo sapiens) 		PF00735
(Septin)
PF00735
(Septin) 		4 PHE A 156
ALA B 188
ILE B 183
PRO B 157
 None
 1.13A 1oniH-2qagA:
undetectable
1oniI-2qagA:
undetectable		 1oniH-2qagA:
16.06
1oniI-2qagA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		4 ARG A  28
ALA A  41
ILE A  70
PRO A  90
 None
 0.98A 1oniH-2qp2A:
undetectable
1oniI-2qp2A:
undetectable		 1oniH-2qp2A:
21.99
1oniI-2qp2A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 ARG A 213
ALA A  20
ILE A 283
PRO A  18
 None
 1.15A 1oniH-2zm5A:
undetectable
1oniI-2zm5A:
undetectable		 1oniH-2zm5A:
22.18
1oniI-2zm5A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zq5 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF13469
(Sulfotransfer_3) 		4 ARG A 179
ALA A  71
ILE A 219
PRO A 128
 None
 1.17A 1oniH-2zq5A:
undetectable
1oniI-2zq5A:
undetectable		 1oniH-2zq5A:
15.42
1oniI-2zq5A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 ALA A 124
TYR A 122
ILE A   9
PRO A 166
 None
 1.12A 1oniH-3a2kA:
undetectable
1oniI-3a2kA:
undetectable		 1oniH-3a2kA:
17.18
1oniI-3a2kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 PHE A 154
ARG A  64
TYR A 102
ILE A  61
 None
 0.89A 1oniH-3b8oA:
undetectable
1oniI-3b8oA:
undetectable		 1oniH-3b8oA:
20.46
1oniI-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		4 PHE A 363
ALA A 196
TYR A 368
ILE A 417
 None
 1.10A 1oniH-3bzmA:
undetectable
1oniI-3bzmA:
undetectable		 1oniH-3bzmA:
15.94
1oniI-3bzmA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04051
(TRAPP)
PF04051
(TRAPP) 		4 PHE D  30
ALA B  57
ILE D 101
PRO D 123
 None
 1.09A 1oniH-3cueD:
undetectable
1oniI-3cueD:
undetectable		 1oniH-3cueD:
21.76
1oniI-3cueD:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dty OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 PHE A 294
ARG A 279
ALA A 280
ILE A 157
 None
 0.90A 1oniH-3dtyA:
1.4
1oniI-3dtyA:
undetectable		 1oniH-3dtyA:
16.15
1oniI-3dtyA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdg DIPEPTIDASE AC.
METALLO PEPTIDASE.
MEROPS FAMILY M19

(Rhodobacter
sphaeroides) 		PF01244
(Peptidase_M19) 		4 ARG A 122
ALA A 118
TYR A 346
ILE A 133
 None
 1.22A 1oniH-3fdgA:
undetectable
1oniI-3fdgA:
0.6		 1oniH-3fdgA:
16.47
1oniI-3fdgA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		4 PHE A  86
ARG A  70
ALA A  66
ILE A 262
 None
 1.22A 1oniH-3ffhA:
undetectable
1oniI-3ffhA:
undetectable		 1oniH-3ffhA:
17.60
1oniI-3ffhA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmy HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA
(YGIT/B3021)

(Escherichia
coli) 		PF15731
(MqsA_antitoxin) 		4 ARG A 101
ALA A 107
ILE A  74
PRO A 109
 None
MEQ  A 108 ( 3.1A)
None
MEQ  A 108 ( 2.6A)
 0.91A 1oniH-3fmyA:
undetectable
1oniI-3fmyA:
undetectable		 1oniH-3fmyA:
20.14
1oniI-3fmyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 ALA A 218
TYR A 223
ILE A 184
PRO A 163
 None
 0.94A 1oniH-3gs6A:
undetectable
1oniI-3gs6A:
undetectable		 1oniH-3gs6A:
18.24
1oniI-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 PHE A 162
ALA A 218
TYR A 223
ILE A 184
 None
 1.22A 1oniH-3gs6A:
undetectable
1oniI-3gs6A:
undetectable		 1oniH-3gs6A:
18.24
1oniI-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iiw POLYCOMB PROTEIN EED

(Homo sapiens) 		PF00400
(WD40) 		4 PHE A 198
ALA A 164
TYR A 186
ILE A 183
 None
 1.17A 1oniH-3iiwA:
undetectable
1oniI-3iiwA:
undetectable		 1oniH-3iiwA:
16.21
1oniI-3iiwA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5j INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3) 		4 ALA A 495
TYR A 491
ILE A 529
PRO A 497
 None
 1.13A 1oniH-3l5jA:
undetectable
1oniI-3l5jA:
undetectable		 1oniH-3l5jA:
21.76
1oniI-3l5jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 PHE A 180
ALA A 198
TYR A 281
ILE A 205
 None
 1.17A 1oniH-3lppA:
1.7
1oniI-3lppA:
undetectable		 1oniH-3lppA:
10.88
1oniI-3lppA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 PHE A  38
ALA A  51
ILE A 242
PRO A  35
 None
 1.09A 1oniH-3m8uA:
undetectable
1oniI-3m8uA:
undetectable		 1oniH-3m8uA:
15.31
1oniI-3m8uA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.07A 1oniH-3ouhA:
undetectable
1oniI-3ouhA:
undetectable		 1oniH-3ouhA:
20.00
1oniI-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oui EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 42Z  A 393 (-2.9A)
42Z  A 393 ( 4.3A)
None
None
 1.03A 1oniH-3ouiA:
undetectable
1oniI-3ouiA:
undetectable		 1oniH-3ouiA:
21.23
1oniI-3ouiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prv NUCLEOSIDE
DIPHOSPHATE KINASE

(Trypanosoma
cruzi) 		PF00334
(NDK) 		4 ALA A  47
TYR A  66
ILE A  72
PRO A  42
 None
 1.16A 1oniH-3prvA:
undetectable
1oniI-3prvA:
undetectable		 1oniH-3prvA:
22.75
1oniI-3prvA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 PHE A 990
ALA A 994
TYR A1026
ILE A 999
 None
 1.19A 1oniH-3psfA:
undetectable
1oniI-3psfA:
undetectable		 1oniH-3psfA:
9.13
1oniI-3psfA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 PHE A 990
ALA A 994
TYR A1026
ILE A 999
 None
 1.23A 1oniH-3psiA:
undetectable
1oniI-3psiA:
undetectable		 1oniH-3psiA:
7.68
1oniI-3psiA:
7.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3h HMW1C-LIKE
GLYCOSYLTRANSFERASE

(Actinobacillus
pleuropneumoniae) 		no annotation 4 ALA A  99
TYR A 477
ILE A 179
PRO A 176
 None
 1.21A 1oniH-3q3hA:
undetectable
1oniI-3q3hA:
undetectable		 1oniH-3q3hA:
12.28
1oniI-3q3hA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q54 OUTER MEMBRANE
ASSEMBLY LIPOPROTEIN
YFGL

(Escherichia
coli) 		PF13360
(PQQ_2) 		4 PHE A  42
ALA A 358
ILE A 390
PRO A  44
 None
 1.17A 1oniH-3q54A:
undetectable
1oniI-3q54A:
undetectable		 1oniH-3q54A:
18.03
1oniI-3q54A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 180
TYR A 401
ILE A 169
PRO A 171
 None
 1.04A 1oniH-3tqpA:
undetectable
1oniI-3tqpA:
undetectable		 1oniH-3tqpA:
16.47
1oniI-3tqpA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 PHE A  77
ALA A 146
ILE A 121
PRO A 118
 URE  A 904 (-4.6A)
None
None
None
 1.11A 1oniH-3umvA:
undetectable
1oniI-3umvA:
0.0		 1oniH-3umvA:
16.89
1oniI-3umvA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 PHE A 237
ALA A 221
ILE A  67
PRO A 511
 None
 1.20A 1oniH-3v5rA:
undetectable
1oniI-3v5rA:
undetectable		 1oniH-3v5rA:
14.37
1oniI-3v5rA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ARG A 383
ALA A 388
ILE A  19
PRO A 109
 GOL  A 812 (-2.7A)
None
None
None
 1.20A 1oniH-3vthA:
undetectable
1oniI-3vthA:
undetectable		 1oniH-3vthA:
11.53
1oniI-3vthA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		4 ARG A 430
ALA A 405
ILE A 370
PRO A 352
 None
 1.04A 1oniH-3wo8A:
undetectable
1oniI-3wo8A:
undetectable		 1oniH-3wo8A:
13.88
1oniI-3wo8A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ALA A 583
TYR A 432
ILE A 498
PRO A 499
 None
 1.16A 1oniH-4cakA:
undetectable
1oniI-4cakA:
undetectable		 1oniH-4cakA:
9.67
1oniI-4cakA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12842
(DUF3819) 		4 ARG A1101
ALA A1097
ILE A1196
PRO A1072
 None
 1.01A 1oniH-4cv5A:
undetectable
1oniI-4cv5A:
undetectable		 1oniH-4cv5A:
20.28
1oniI-4cv5A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f36 NUCLEOSIDE
DIPHOSPHATE KINASE

(Trypanosoma
brucei) 		PF00334
(NDK) 		4 ALA A  47
TYR A  66
ILE A  72
PRO A  42
 None
 1.11A 1oniH-4f36A:
undetectable
1oniI-4f36A:
undetectable		 1oniH-4f36A:
23.31
1oniI-4f36A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 PHE A 505
ALA A 548
ILE A 563
PRO A 577
 None
 1.23A 1oniH-4g56A:
undetectable
1oniI-4g56A:
1.5		 1oniH-4g56A:
11.42
1oniI-4g56A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		4 ALA A 224
TYR A 229
ILE A 189
PRO A 166
 None
 1.05A 1oniH-4gvfA:
undetectable
1oniI-4gvfA:
undetectable		 1oniH-4gvfA:
15.34
1oniI-4gvfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		4 PHE A 165
ALA A 224
TYR A 229
ILE A 189
 None
 1.22A 1oniH-4gvfA:
undetectable
1oniI-4gvfA:
undetectable		 1oniH-4gvfA:
15.34
1oniI-4gvfA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 432
ARG A 418
ALA A 422
ILE A  34
 None
 1.10A 1oniH-4hjlA:
undetectable
1oniI-4hjlA:
undetectable		 1oniH-4hjlA:
14.62
1oniI-4hjlA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jz6 SALICYLALDEHYDE
DEHYDROGENASE NAHF

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 PHE A 277
ALA A 363
ILE A 336
PRO A 383
 None
 1.17A 1oniH-4jz6A:
undetectable
1oniI-4jz6A:
undetectable		 1oniH-4jz6A:
13.57
1oniI-4jz6A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lp2 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR CYSB

(Salmonella
enterica) 		PF03466
(LysR_substrate) 		4 PHE B 201
ALA B 151
ILE B 134
PRO B 131
 None
 1.22A 1oniH-4lp2B:
undetectable
1oniI-4lp2B:
undetectable		 1oniH-4lp2B:
22.18
1oniI-4lp2B:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		4 ALA A  65
TYR A  56
ILE A 155
PRO A 287
 None
 1.19A 1oniH-4ls3A:
undetectable
1oniI-4ls3A:
undetectable		 1oniH-4ls3A:
19.69
1oniI-4ls3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 178
TYR A 403
ILE A 167
PRO A 169
 None
 1.04A 1oniH-4mksA:
undetectable
1oniI-4mksA:
0.7		 1oniH-4mksA:
17.02
1oniI-4mksA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		4 ARG A 107
ALA A 106
ILE A 172
PRO A  94
 None
 1.02A 1oniH-4n30A:
undetectable
1oniI-4n30A:
undetectable		 1oniH-4n30A:
17.89
1oniI-4n30A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ojz PUTATIVE ALGINATE
LYASE

(Saccharophagus
degradans) 		PF05426
(Alginate_lyase)
PF07940
(Hepar_II_III) 		4 PHE A 307
ARG A 392
ALA A 401
TYR A 372
 None
 1.13A 1oniH-4ojzA:
undetectable
1oniI-4ojzA:
undetectable		 1oniH-4ojzA:
12.10
1oniI-4ojzA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 PHE A 234
ALA A 309
ILE A 251
PRO A 238
 None
 1.18A 1oniH-4pbxA:
undetectable
1oniI-4pbxA:
undetectable		 1oniH-4pbxA:
13.68
1oniI-4pbxA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 PHE A 858
ALA A 816
ILE A 821
PRO A 870
 None
 1.08A 1oniH-4q73A:
0.3
1oniI-4q73A:
undetectable		 1oniH-4q73A:
10.72
1oniI-4q73A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 ALA A 200
TYR A 212
ILE A 181
PRO A 172
 None
 1.12A 1oniH-4qawA:
1.3
1oniI-4qawA:
undetectable		 1oniH-4qawA:
14.77
1oniI-4qawA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsp PROTEIN DL-RV1738

(Mycobacterium
tuberculosis) 		PF08962
(DUF1876) 		4 ARG A  65
ALA A  45
ILE A  57
PRO A  49
 CL  A 101 ( 3.5A)
CL  A 101 ( 4.0A)
None
None
 1.05A 1oniH-4wspA:
undetectable
1oniI-4wspA:
undetectable		 1oniH-4wspA:
26.09
1oniI-4wspA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 PHE A 245
ALA A 320
ILE A 262
PRO A 249
 None
 1.09A 1oniH-4y61A:
undetectable
1oniI-4y61A:
undetectable		 1oniH-4y61A:
18.13
1oniI-4y61A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		no annotation 4 PHE B 235
ALA B 310
ILE B 252
PRO B 239
 None
 1.02A 1oniH-4yfgB:
undetectable
1oniI-4yfgB:
undetectable		 1oniH-4yfgB:
15.14
1oniI-4yfgB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		4 ALA D 159
TYR D 132
ILE D 169
PRO D 170
 None
 1.17A 1oniH-4yg7D:
undetectable
1oniI-4yg7D:
undetectable		 1oniH-4yg7D:
17.63
1oniI-4yg7D:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 PHE A 151
ALA A 145
ILE A 123
PRO A 153
 None
 1.12A 1oniH-4zwvA:
undetectable
1oniI-4zwvA:
undetectable		 1oniH-4zwvA:
21.21
1oniI-4zwvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ARG A 429
ALA A 277
ILE A 398
PRO A 396
 None
 1.03A 1oniH-5aq1A:
0.7
1oniI-5aq1A:
0.8		 1oniH-5aq1A:
13.88
1oniI-5aq1A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5caa NUCLEOSIDE
DIPHOSPHATE KINASE

(Leishmania
major) 		PF00334
(NDK) 		4 ALA A  47
TYR A  66
ILE A  72
PRO A  42
 None
 1.16A 1oniH-5caaA:
undetectable
1oniI-5caaA:
undetectable		 1oniH-5caaA:
24.14
1oniI-5caaA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron;
Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2)
PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PHE A 226
ALA A  31
ILE B 614
PRO A 235
 None
 1.09A 1oniH-5fq6A:
undetectable
1oniI-5fq6A:
undetectable		 1oniH-5fq6A:
14.59
1oniI-5fq6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 PHE A 158
ARG A  67
ALA A  84
PRO A  88
 None
 1.19A 1oniH-5jd5A:
0.7
1oniI-5jd5A:
undetectable		 1oniH-5jd5A:
18.99
1oniI-5jd5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF00008
(EGF) 		4 ARG C  22
ALA C  31
ILE A  57
PRO A  55
 None
 0.97A 1oniH-5kn5C:
undetectable
1oniI-5kn5C:
undetectable		 1oniH-5kn5C:
11.59
1oniI-5kn5C:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A1203
ARG A1177
ALA A1173
ILE A1158
 None
 1.22A 1oniH-5m3cA:
undetectable
1oniI-5m3cA:
undetectable		 1oniH-5m3cA:
undetectable
1oniI-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 PHE A 220
ALA A 452
ILE A 248
PRO A 246
 None
 1.16A 1oniH-5nlmA:
undetectable
1oniI-5nlmA:
undetectable		 1oniH-5nlmA:
undetectable
1oniI-5nlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 PHE A 459
ALA A 455
ILE A 494
PRO A 495
 None
 1.01A 1oniH-5no8A:
undetectable
1oniI-5no8A:
undetectable		 1oniH-5no8A:
12.10
1oniI-5no8A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		4 PHE A 869
ALA A 889
ILE A 984
PRO A 893
 None
 1.17A 1oniH-5t8vA:
undetectable
1oniI-5t8vA:
0.7		 1oniH-5t8vA:
7.14
1oniI-5t8vA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukw GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Homo sapiens) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 ARG A 387
ALA A 231
ILE A 355
PRO A 353
 None
 1.07A 1oniH-5ukwA:
undetectable
1oniI-5ukwA:
0.7		 1oniH-5ukwA:
15.20
1oniI-5ukwA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 PHE A 844
ALA A 802
ILE A 807
PRO A 857
 None
 1.06A 1oniH-5ur2A:
undetectable
1oniI-5ur2A:
undetectable		 1oniH-5ur2A:
10.16
1oniI-5ur2A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uwb TOLUENE TOLERANCE
PROTEIN

(Pseudomonas
putida) 		no annotation 4 PHE B 173
ALA B 202
TYR B 105
ILE B 167
 None
None
PEF  B 301 (-4.0A)
None
 1.23A 1oniH-5uwbB:
undetectable
1oniI-5uwbB:
undetectable		 1oniH-5uwbB:
21.82
1oniI-5uwbB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 4 PHE A 223
ALA A 186
TYR A 207
ILE A 193
 None
 1.21A 1oniH-5wnmA:
undetectable
1oniI-5wnmA:
undetectable		 1oniH-5wnmA:
undetectable
1oniI-5wnmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		4 PHE A 430
ARG A 416
ALA A 420
ILE A  32
 None
 1.13A 1oniH-5xbpA:
undetectable
1oniI-5xbpA:
undetectable		 1oniH-5xbpA:
14.89
1oniI-5xbpA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Homo sapiens) 		no annotation 4 PHE D 229
ALA D 304
ILE D 246
PRO D 233
 None
 1.23A 1oniH-5xnpD:
undetectable
1oniI-5xnpD:
undetectable		 1oniH-5xnpD:
undetectable
1oniI-5xnpD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvd HYDROGENASE-2 SMALL
CHAIN

(Citrobacter sp.
MGH106) 		no annotation 4 PHE S 185
ALA S 163
ILE S 149
PRO S 175
 None
 1.21A 1oniH-5xvdS:
undetectable
1oniI-5xvdS:
undetectable		 1oniH-5xvdS:
undetectable
1oniI-5xvdS:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 4 PHE A 186
ALA A 229
ILE A 182
PRO A 185
 None
 0.91A 1oniH-6ao5A:
undetectable
1oniI-6ao5A:
undetectable		 1oniH-6ao5A:
18.99
1oniI-6ao5A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 4 PHE 1  81
ALA 1  83
TYR 1  66
ILE 1  51
 None
 1.04A 1oniH-6c261:
undetectable
1oniI-6c261:
undetectable		 1oniH-6c261:
undetectable
1oniI-6c261:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cl5 TAIL FIBER PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 397
ARG A 431
ALA A 405
ILE A 393
 None
 1.22A 1oniH-6cl5A:
undetectable
1oniI-6cl5A:
undetectable		 1oniH-6cl5A:
undetectable
1oniI-6cl5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cl6 TAIL FIBER PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A 397
ARG A 431
ALA A 405
ILE A 393
 None
 1.22A 1oniH-6cl6A:
undetectable
1oniI-6cl6A:
undetectable		 1oniH-6cl6A:
undetectable
1oniI-6cl6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eh1 STRUCTURAL PROTEIN
VP3

(Sacbrood virus) 		no annotation 4 ARG C 179
TYR C 174
ILE C 116
PRO C  86
 None
 1.22A 1oniH-6eh1C:
undetectable
1oniI-6eh1C:
undetectable		 1oniH-6eh1C:
undetectable
1oniI-6eh1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en9 HYDROGENASE-2 SMALL
CHAIN

(Escherichia
coli) 		no annotation 4 PHE S 185
ALA S 163
ILE S 149
PRO S 175
 None
 1.17A 1oniH-6en9S:
undetectable
1oniI-6en9S:
undetectable		 1oniH-6en9S:
undetectable
1oniI-6en9S:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
3, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT 5

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 PHE C  63
ALA C  70
TYR C  28
ILE V  50
 None
 0.77A 1oniH-6g2jC:
undetectable
1oniI-6g2jC:
undetectable		 1oniH-6g2jC:
undetectable
1oniI-6g2jC:
undetectable