SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_E_BEZE509

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 ILE A  45
GLU A  40
PHE A  69
ALA A  38
 None
 1.14A 1oniD-1a5cA:
0.0
1oniE-1a5cA:
0.6		 1oniD-1a5cA:
16.90
1oniE-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 ILE A 408
PRO A 500
PHE A 332
ALA A 363
 None
 1.07A 1oniD-1d4eA:
0.0
1oniE-1d4eA:
0.0		 1oniD-1d4eA:
13.69
1oniE-1d4eA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpp DIPEPTIDE BINDING
PROTEIN

(Escherichia
coli) 		PF00496
(SBP_bac_5) 		4 ILE A 218
PRO A  11
PHE A  14
ALA A  27
 None
 1.01A 1oniD-1dppA:
0.0
1oniE-1dppA:
0.0		 1oniD-1dppA:
14.26
1oniE-1dppA:
14.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA
MATURE CAPSID
PROTEIN GAMMA

(Pariacoto
virus;
Pariacoto virus) 		PF01829
(Peptidase_A6)
no annotation 		4 TYR D 400
ILE A  77
PRO A  78
ALA A 341
 None
 1.17A 1oniD-1f8vD:
undetectable
1oniE-1f8vD:
undetectable		 1oniD-1f8vD:
13.24
1oniE-1f8vD:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h04 COMPLEMENT
DECAY-ACCELERATING
FACTOR

(Homo sapiens) 		PF00084
(Sushi) 		4 ILE P  13
PRO P  62
ARG P  65
ALA P  41
 None
 1.17A 1oniD-1h04P:
undetectable
1oniE-1h04P:
undetectable		 1oniD-1h04P:
21.15
1oniE-1h04P:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 403
ILE A 166
PRO A 168
ALA A 177
 None
 1.03A 1oniD-1iyxA:
undetectable
1oniE-1iyxA:
undetectable		 1oniD-1iyxA:
15.70
1oniE-1iyxA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j7h HYPOTHETICAL PROTEIN
HI0719

(Haemophilus
influenzae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 116
GLU A 122
 None
 0.66A 1oniD-1j7hA:
19.0
1oniE-1j7hA:
19.1		 1oniD-1j7hA:
42.96
1oniE-1j7hA:
42.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd1 HYPOTHETICAL 13.9
KDA PROTEIN IN
FCY2-PET117
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 114
GLU A 120
 None
 0.66A 1oniD-1jd1A:
22.7
1oniE-1jd1A:
22.8		 1oniD-1jd1A:
38.64
1oniE-1jd1A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jro XANTHINE
DEHYDROGENASE, CHAIN
A

(Rhodobacter
capsulatus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01799
(Fer2_2)
PF03450
(CO_deh_flav_C) 		4 ILE A  78
PRO A 108
PHE A 105
ALA A  46
 None
None
None
FES  A3002 ( 4.9A)
 1.08A 1oniD-1jroA:
undetectable
1oniE-1jroA:
undetectable		 1oniD-1jroA:
15.95
1oniE-1jroA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m64 FLAVOCYTOCHROME C3

(Shewanella
frigidimarina) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		4 ILE A 409
PRO A 501
PHE A 333
ALA A 364
 None
 0.92A 1oniD-1m64A:
undetectable
1oniE-1m64A:
undetectable		 1oniD-1m64A:
17.90
1oniE-1m64A:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nox NADH OXIDASE

(Thermus
thermophilus) 		PF00881
(Nitroreductase) 		4 ILE A 177
PHE A  71
ARG A 164
ALA A  69
 None
 1.13A 1oniD-1noxA:
undetectable
1oniE-1noxA:
undetectable		 1oniD-1noxA:
22.38
1oniE-1noxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C) 		4 ILE D 730
PHE D 671
ARG D 638
ALA D 640
 None
 0.94A 1oniD-1o7dD:
undetectable
1oniE-1o7dD:
undetectable		 1oniD-1o7dD:
18.28
1oniE-1o7dD:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ILE A 150
PRO A 149
ARG A 141
ALA A 145
 None
 1.07A 1oniD-1odoA:
undetectable
1oniE-1odoA:
undetectable		 1oniD-1odoA:
19.55
1oniE-1odoA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odt CEPHALOSPORIN C
DEACETYLASE

(Bacillus
subtilis) 		PF05448
(AXE1) 		4 TYR C  88
ILE C 175
PRO C 197
ALA C 200
 None
 1.14A 1oniD-1odtC:
undetectable
1oniE-1odtC:
undetectable		 1oniD-1odtC:
17.72
1oniE-1odtC:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oni 14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN

(Homo sapiens) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  21
ILE A  37
PRO A 116
GLU A 122
 None
 0.25A 1oniD-1oniA:
27.1
1oniE-1oniA:
26.8		 1oniD-1oniA:
100.00
1oniE-1oniA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 408
ILE A 169
PRO A 171
ALA A 180
 None
 0.98A 1oniD-1pdzA:
undetectable
1oniE-1pdzA:
undetectable		 1oniD-1pdzA:
14.75
1oniE-1pdzA:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 115
GLU A 121
 None
 0.37A 1oniD-1qahA:
26.1
1oniE-1qahA:
26.2		 1oniD-1qahA:
87.50
1oniE-1qahA:
87.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qd9 PURINE REGULATORY
PROTEIN YABJ

(Bacillus
subtilis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 111
GLU A 117
 None
 0.43A 1oniD-1qd9A:
23.3
1oniE-1qd9A:
23.4		 1oniD-1qd9A:
42.22
1oniE-1qd9A:
42.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.46A 1oniD-1qu9A:
22.1
1oniE-1qu9A:
22.2		 1oniD-1qu9A:
44.78
1oniE-1qu9A:
44.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcl HEMOLYTIC LECTIN
CEL-III

(Cucumaria
echinata) 		PF00652
(Ricin_B_lectin) 		4 ILE A 403
PRO A 417
PHE A 336
ALA A 291
 BTB  A1301 ( 4.9A)
None
None
None
 1.16A 1oniD-1vclA:
undetectable
1oniE-1vclA:
undetectable		 1oniD-1vclA:
18.44
1oniE-1vclA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzv VARICELLA-ZOSTER
VIRUS PROTEASE

(Human
alphaherpesvirus
3) 		PF00716
(Peptidase_S21) 		4 ILE A  64
PRO A  71
ARG A 148
ALA A  20
 None
 1.16A 1oniD-1vzvA:
undetectable
1oniE-1vzvA:
undetectable		 1oniD-1vzvA:
23.38
1oniE-1vzvA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 ILE J 237
PRO J 304
PHE J  82
ALA J  70
 None
 1.03A 1oniD-1wcdJ:
undetectable
1oniE-1wcdJ:
undetectable		 1oniD-1wcdJ:
18.18
1oniE-1wcdJ:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811

(Sulfurisphaera
tokodaii) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.38A 1oniD-1x25A:
24.2
1oniE-1x25A:
24.3		 1oniD-1x25A:
43.61
1oniE-1x25A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY

(Ruminiclostridium
thermocellum) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.53A 1oniD-1xrgA:
24.0
1oniE-1xrgA:
24.2		 1oniD-1xrgA:
44.52
1oniE-1xrgA:
44.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ag1 BENZALDEHYDE LYASE

(Pseudomonas
fluorescens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ILE A 292
PRO A 293
ARG A 206
ALA A 269
 None
 1.14A 1oniD-2ag1A:
undetectable
1oniE-2ag1A:
undetectable		 1oniD-2ag1A:
13.03
1oniE-2ag1A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 406
ILE A 169
PRO A 171
ALA A 180
 None
 0.96A 1oniD-2akzA:
undetectable
1oniE-2akzA:
undetectable		 1oniD-2akzA:
17.78
1oniE-2akzA:
17.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b33 PROTEIN SYNTHESIS
INHIBITOR, PUTATIVE

(Thermotoga
maritima) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 112
GLU A 118
 None
 0.38A 1oniD-2b33A:
23.4
1oniE-2b33A:
23.3		 1oniD-2b33A:
42.14
1oniE-2b33A:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR

(Thermus
thermophilus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  16
ILE A  32
PRO A 110
GLU A 116
 None
 0.84A 1oniD-2cvlA:
22.9
1oniE-2cvlA:
22.9		 1oniD-2cvlA:
40.15
1oniE-2cvlA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db8 TRIPARTITE MOTIF
PROTEIN 9, ISOFORM 2

(Homo sapiens) 		PF00041
(fn3) 		4 TYR A  44
ILE A  14
PRO A  34
ALA A  11
 None
 1.15A 1oniD-2db8A:
undetectable
1oniE-2db8A:
undetectable		 1oniD-2db8A:
23.40
1oniE-2db8A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		4 ILE A  48
PRO A  84
GLU A  54
ALA A  85
 None
 1.15A 1oniD-2eq5A:
undetectable
1oniE-2eq5A:
undetectable		 1oniD-2eq5A:
21.27
1oniE-2eq5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		4 ILE B 175
PRO B  88
GLU B 172
ALA B  86
 None
 1.08A 1oniD-2f9iB:
undetectable
1oniE-2f9iB:
undetectable		 1oniD-2f9iB:
17.56
1oniE-2f9iB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 PRO H 484
PHE H 491
ARG H 515
ALA H 514
 None
 1.02A 1oniD-2fhgH:
undetectable
1oniE-2fhgH:
undetectable		 1oniD-2fhgH:
23.01
1oniE-2fhgH:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 405
ILE A 170
PRO A 172
ALA A 181
 None
 1.00A 1oniD-2fymA:
undetectable
1oniE-2fymA:
undetectable		 1oniD-2fymA:
17.80
1oniE-2fymA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 218
PRO A 156
GLU A 217
ARG A 213
 None
None
None
SO4  A 410 (-3.0A)
 0.98A 1oniD-2g17A:
undetectable
1oniE-2g17A:
undetectable		 1oniD-2g17A:
19.53
1oniE-2g17A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 504
GLU A 524
PHE A 479
ARG A 512
 None
 1.16A 1oniD-2hivA:
undetectable
1oniE-2hivA:
undetectable		 1oniD-2hivA:
13.06
1oniE-2hivA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx6 RIBONUCLEASE

(Escherichia
virus T4) 		PF10715
(REGB_T4) 		4 TYR A  45
ILE A  54
PHE A  64
ALA A 134
 None
 1.05A 1oniD-2hx6A:
undetectable
1oniE-2hx6A:
undetectable		 1oniD-2hx6A:
25.14
1oniE-2hx6A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivy HYPOTHETICAL PROTEIN
SSO1404

(Sulfolobus
solfataricus) 		PF09827
(CRISPR_Cas2) 		4 TYR A  34
ILE A  11
ARG A  31
ALA A  21
 None
 1.14A 1oniD-2ivyA:
undetectable
1oniE-2ivyA:
undetectable		 1oniD-2ivyA:
21.54
1oniE-2ivyA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvo RO SIXTY-RELATED
PROTEIN, RSR

(Deinococcus
radiodurans) 		PF05731
(TROVE) 		4 TYR A 460
ILE A 395
PHE A 515
ALA A 388
 None
 1.07A 1oniD-2nvoA:
undetectable
1oniE-2nvoA:
undetectable		 1oniD-2nvoA:
14.77
1oniE-2nvoA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocd L-ASPARAGINASE I

(Vibrio cholerae) 		PF00710
(Asparaginase) 		4 ILE A  15
GLU A  32
PHE A  41
ALA A  36
 None
 1.16A 1oniD-2ocdA:
undetectable
1oniE-2ocdA:
undetectable		 1oniD-2ocdA:
17.54
1oniE-2ocdA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p10 MLL9387 PROTEIN

(Mesorhizobium
japonicum) 		PF09370
(PEP_hydrolase) 		4 ILE A  51
GLU A  43
ARG A  60
ALA A 258
 None
None
CL  A 290 (-2.9A)
CL  A 290 (-4.0A)
 1.17A 1oniD-2p10A:
undetectable
1oniE-2p10A:
undetectable		 1oniD-2p10A:
22.10
1oniE-2p10A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 403
ILE A 173
PRO A 175
ALA A 184
 None
 0.99A 1oniD-2pa6A:
undetectable
1oniE-2pa6A:
undetectable		 1oniD-2pa6A:
17.28
1oniE-2pa6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		4 ILE A  70
PRO A  90
ARG A  28
ALA A  41
 None
 0.96A 1oniD-2qp2A:
undetectable
1oniE-2qp2A:
undetectable		 1oniD-2qp2A:
21.99
1oniE-2qp2A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.48A 1oniD-2uykA:
22.2
1oniE-2uykA:
22.3		 1oniD-2uykA:
39.01
1oniE-2uykA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA

(Rattus
norvegicus;
Homo sapiens) 		PF01602
(Adaptin_N)
PF01602
(Adaptin_N) 		4 TYR B 524
ILE A 470
GLU A 506
ARG B 528
 None
 1.14A 1oniD-2xa7B:
undetectable
1oniE-2xa7B:
undetectable		 1oniD-2xa7B:
12.28
1oniE-2xa7B:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 407
ILE A 170
PRO A 172
ALA A 181
 None
 1.02A 1oniD-2xsxA:
undetectable
1oniE-2xsxA:
undetectable		 1oniD-2xsxA:
16.59
1oniE-2xsxA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 1.03A 1oniD-3b8oA:
undetectable
1oniE-3b8oA:
undetectable		 1oniD-3b8oA:
20.46
1oniE-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 406
ILE A 169
PRO A 171
ALA A 180
 None
 1.00A 1oniD-3b97A:
undetectable
1oniE-3b97A:
undetectable		 1oniD-3b97A:
20.62
1oniE-3b97A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 127
GLU A 124
PHE A 274
ALA A 277
 None
 1.01A 1oniD-3coiA:
undetectable
1oniE-3coiA:
undetectable		 1oniD-3coiA:
18.36
1oniE-3coiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		4 TYR A 733
GLU A 760
PHE A 659
ALA A 698
 None
 1.13A 1oniD-3cttA:
undetectable
1oniE-3cttA:
undetectable		 1oniD-3cttA:
10.62
1oniE-3cttA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cue TRANSPORT PROTEIN
PARTICLE 31 KDA
SUBUNIT
TRANSPORT PROTEIN
PARTICLE 22 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04051
(TRAPP)
PF04051
(TRAPP) 		4 ILE D 101
PRO D 123
PHE D  30
ALA B  57
 None
 1.07A 1oniD-3cueD:
undetectable
1oniE-3cueD:
undetectable		 1oniD-3cueD:
21.76
1oniE-3cueD:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3do6 FORMATE--TETRAHYDROF
OLATE LIGASE

(Thermotoga
maritima) 		PF01268
(FTHFS) 		4 ILE A 193
GLU A 189
ARG A 222
ALA A 503
 None
 1.16A 1oniD-3do6A:
undetectable
1oniE-3do6A:
undetectable		 1oniD-3do6A:
14.81
1oniE-3do6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		4 ILE A 262
PHE A  86
ARG A  70
ALA A  66
 None
 1.12A 1oniD-3ffhA:
undetectable
1oniE-3ffhA:
undetectable		 1oniD-3ffhA:
17.60
1oniE-3ffhA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmy HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA
(YGIT/B3021)

(Escherichia
coli) 		PF15731
(MqsA_antitoxin) 		4 ILE A  74
PRO A 109
ARG A 101
ALA A 107
 None
MEQ  A 108 ( 2.6A)
None
MEQ  A 108 ( 3.1A)
 0.91A 1oniD-3fmyA:
undetectable
1oniE-3fmyA:
undetectable		 1oniD-3fmyA:
20.14
1oniE-3fmyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 TYR A 223
ILE A 184
PRO A 163
ALA A 218
 None
 0.87A 1oniD-3gs6A:
undetectable
1oniE-3gs6A:
undetectable		 1oniD-3gs6A:
18.24
1oniE-3gs6A:
18.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k0t ENDORIBONUCLEASE
L-PSP, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 112
GLU A 118
 BGC  A 127 (-3.1A)
BGC  A 127 (-4.0A)
None
BGC  A 127 (-3.5A)
 0.47A 1oniD-3k0tA:
23.3
1oniE-3k0tA:
23.4		 1oniD-3k0tA:
40.94
1oniE-3k0tA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 ILE A  37
GLU A  32
PHE A  61
ALA A  30
 None
 1.00A 1oniD-3kx6A:
undetectable
1oniE-3kx6A:
undetectable		 1oniD-3kx6A:
20.11
1oniE-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll7 PUTATIVE
METHYLTRANSFERASE

(Porphyromonas
gingivalis) 		no annotation 4 ILE A 279
GLU A 276
PHE A 269
ALA A 303
 None
 1.16A 1oniD-3ll7A:
undetectable
1oniE-3ll7A:
undetectable		 1oniD-3ll7A:
16.63
1oniE-3ll7A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m8u HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 ILE A 242
PRO A  35
PHE A  38
ALA A  51
 None
 1.16A 1oniD-3m8uA:
undetectable
1oniE-3m8uA:
undetectable		 1oniD-3m8uA:
15.31
1oniE-3m8uA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 ILE A  29
GLU A  24
PHE A  53
ALA A  22
 None
2FP  A 350 ( 4.9A)
None
None
 1.00A 1oniD-3mmtA:
undetectable
1oniE-3mmtA:
undetectable		 1oniD-3mmtA:
19.88
1oniE-3mmtA:
19.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mqw PUTATIVE
ENDORIBONUCLEASE
L-PSP

(Entamoeba
histolytica) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 FLC  A 140 (-4.0A)
FLC  A 140 (-4.8A)
FLC  A 140 (-4.5A)
FLC  A 140 (-2.8A)
 0.42A 1oniD-3mqwA:
23.0
1oniE-3mqwA:
22.9		 1oniD-3mqwA:
42.75
1oniE-3mqwA:
42.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 419
ILE A 177
PRO A 179
ALA A 188
 None
 1.03A 1oniD-3otrA:
undetectable
1oniE-3otrA:
undetectable		 1oniD-3otrA:
15.90
1oniE-3otrA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 TYR A 303
ILE A 256
ARG A 383
ALA A 385
 None
None
014  A 417 (-3.1A)
014  A 417 ( 3.9A)
 1.06A 1oniD-3ouhA:
undetectable
1oniE-3ouhA:
undetectable		 1oniD-3ouhA:
20.00
1oniE-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		5 TYR A 288
ILE A  95
PRO A 165
GLU A 109
PHE A 162
 None
 1.47A 1oniD-3prlA:
undetectable
1oniE-3prlA:
undetectable		 1oniD-3prlA:
17.49
1oniE-3prlA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qn3 ENOLASE

(Campylobacter
jejuni) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 396
ILE A 166
PRO A 168
ALA A 177
 None
 1.16A 1oniD-3qn3A:
undetectable
1oniE-3qn3A:
undetectable		 1oniD-3qn3A:
16.15
1oniE-3qn3A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 411
ILE A 168
PRO A 170
ALA A 179
 None
 1.00A 1oniD-3qtpA:
undetectable
1oniE-3qtpA:
undetectable		 1oniD-3qtpA:
15.91
1oniE-3qtpA:
15.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quw PROTEIN MMF1

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  36
ILE A  52
PRO A 130
GLU A 136
 None
 0.32A 1oniD-3quwA:
22.6
1oniE-3quwA:
22.7		 1oniD-3quwA:
32.68
1oniE-3quwA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0p L-PSP PUTATIVE
ENDORIBONUCLEASE

(uncultured
organism) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 None
 0.52A 1oniD-3r0pA:
23.6
1oniE-3r0pA:
23.6		 1oniD-3r0pA:
43.18
1oniE-3r0pA:
43.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqp ENOLASE

(Coxiella
burnetii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 401
ILE A 169
PRO A 171
ALA A 180
 None
 0.94A 1oniD-3tqpA:
undetectable
1oniE-3tqpA:
undetectable		 1oniD-3tqpA:
16.47
1oniE-3tqpA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 405
ILE A 169
PRO A 171
ALA A 180
 None
 1.02A 1oniD-3uj2A:
undetectable
1oniE-3uj2A:
undetectable		 1oniD-3uj2A:
15.10
1oniE-3uj2A:
15.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vcz ENDORIBONUCLEASE
L-PSP

(Vibrio
vulnificus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 115
GLU A 121
 None
 0.39A 1oniD-3vczA:
21.7
1oniE-3vczA:
21.7		 1oniD-3vczA:
37.01
1oniE-3vczA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3r ENOLASE

(Bacillus
subtilis) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 403
ILE A 167
PRO A 169
ALA A 178
 None
 0.98A 1oniD-4a3rA:
undetectable
1oniE-4a3rA:
undetectable		 1oniD-4a3rA:
17.29
1oniE-4a3rA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 TYR A 432
ILE A 498
PRO A 499
ALA A 583
 None
 1.08A 1oniD-4cakA:
undetectable
1oniE-4cakA:
undetectable		 1oniD-4cakA:
9.67
1oniE-4cakA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyl EFF-1A

(Caenorhabditis
elegans) 		PF14884
(EFF-AFF) 		4 ILE A 449
GLU A 360
PHE A 434
ALA A 436
 None
 1.15A 1oniD-4cylA:
undetectable
1oniE-4cylA:
undetectable		 1oniD-4cylA:
12.42
1oniE-4cylA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 ILE A 110
GLU A 105
PHE A 134
ALA A 103
 None
 1.00A 1oniD-4d2jA:
undetectable
1oniE-4d2jA:
undetectable		 1oniD-4d2jA:
17.75
1oniE-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eq9 ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 TYR A 229
ILE A 275
PRO A 270
ALA A 122
 None
 1.13A 1oniD-4eq9A:
undetectable
1oniE-4eq9A:
undetectable		 1oniD-4eq9A:
18.26
1oniE-4eq9A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewg BETA-KETOACYL
SYNTHASE

(Paraburkholderia
phymatum) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 178
GLU A 242
ARG A 249
ALA A 246
 None
 1.02A 1oniD-4ewgA:
undetectable
1oniE-4ewgA:
undetectable		 1oniD-4ewgA:
18.38
1oniE-4ewgA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ILE W 471
PRO W 435
GLU W 390
ARG W 814
 None
 1.10A 1oniD-4f5xW:
undetectable
1oniE-4f5xW:
undetectable		 1oniD-4f5xW:
8.95
1oniE-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 178
GLU A 243
ARG A 250
ALA A 247
 None
 1.04A 1oniD-4jb6A:
undetectable
1oniE-4jb6A:
undetectable		 1oniD-4jb6A:
15.37
1oniE-4jb6A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 403
ILE A 167
PRO A 169
ALA A 178
 None
 0.96A 1oniD-4mksA:
undetectable
1oniE-4mksA:
undetectable		 1oniD-4mksA:
17.02
1oniE-4mksA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnn GLUTAREDOXIN RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF13192
(Thioredoxin_3) 		4 TYR A  60
PRO A  73
GLU A  70
ALA A 118
 None
 1.04A 1oniD-4mnnA:
undetectable
1oniE-4mnnA:
undetectable		 1oniD-4mnnA:
24.31
1oniE-4mnnA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		5 ILE A 821
PRO A 870
PHE A 858
ARG A 817
ALA A 816
 None
 1.43A 1oniD-4q73A:
undetectable
1oniE-4q73A:
undetectable		 1oniD-4q73A:
10.72
1oniE-4q73A:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 TYR A 212
ILE A 181
PRO A 172
ALA A 200
 None
 0.97A 1oniD-4qawA:
undetectable
1oniE-4qawA:
undetectable		 1oniD-4qawA:
14.77
1oniE-4qawA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 ILE A 177
GLU A 242
ARG A 249
ALA A 246
 None
 1.11A 1oniD-4r8eA:
undetectable
1oniE-4r8eA:
undetectable		 1oniD-4r8eA:
16.42
1oniE-4r8eA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		PF02706
(Wzz) 		4 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 1.00A 1oniD-4wl1A:
undetectable
1oniE-4wl1A:
undetectable		 1oniD-4wl1A:
18.03
1oniE-4wl1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsp PROTEIN DL-RV1738

(Mycobacterium
tuberculosis) 		PF08962
(DUF1876) 		4 ILE A  57
PRO A  49
ARG A  65
ALA A  45
 None
None
CL  A 101 ( 3.5A)
CL  A 101 ( 4.0A)
 1.12A 1oniD-4wspA:
undetectable
1oniE-4wspA:
undetectable		 1oniD-4wspA:
26.09
1oniE-4wspA:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwv PUTATIVE
AMINOTRANSFERASE

(Actinomadura
melliaura) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 123
PRO A 153
PHE A 151
ALA A 145
 None
 1.13A 1oniD-4zwvA:
undetectable
1oniE-4zwvA:
undetectable		 1oniD-4zwvA:
21.21
1oniE-4zwvA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA) 		4 ILE A 236
PRO A  21
ARG A 261
ALA A  45
 None
 1.10A 1oniD-5ey5A:
undetectable
1oniE-5ey5A:
undetectable		 1oniD-5ey5A:
22.75
1oniE-5ey5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN

(Yersinia pestis) 		PF00496
(SBP_bac_5) 		4 ILE A 246
PRO A  39
PHE A  42
ALA A  55
 None
None
EDO  A 610 ( 4.9A)
None
 1.02A 1oniD-5f1qA:
undetectable
1oniE-5f1qA:
undetectable		 1oniD-5f1qA:
14.00
1oniE-5f1qA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		4 ILE A 496
GLU A 525
PHE A 544
ALA A 549
 None
 1.15A 1oniD-5hdhA:
undetectable
1oniE-5hdhA:
undetectable		 1oniD-5hdhA:
13.04
1oniE-5hdhA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp6 EXTRACELLULAR
ARABINANASE

(Geobacillus
stearothermophilus) 		PF04616
(Glyco_hydro_43)
PF13385
(Laminin_G_3)
PF16369
(GH43_C) 		4 TYR A 346
ILE A 293
PHE A 242
ALA A 252
 None
 1.14A 1oniD-5hp6A:
undetectable
1oniE-5hp6A:
undetectable		 1oniD-5hp6A:
11.41
1oniE-5hp6A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Homo sapiens;
Homo sapiens) 		PF01192
(RNA_pol_Rpb6)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 ILE F 102
PRO F 103
GLU F  96
PHE G  18
 None
 1.15A 1oniD-5iy9F:
undetectable
1oniE-5iy9F:
undetectable		 1oniD-5iy9F:
19.35
1oniE-5iy9F:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j04 ENOLASE

(Synechococcus
elongatus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 403
ILE A 171
PRO A 173
ALA A 182
 None
 1.05A 1oniD-5j04A:
undetectable
1oniE-5j04A:
undetectable		 1oniD-5j04A:
19.61
1oniE-5j04A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF00008
(EGF) 		4 ILE A  57
PRO A  55
ARG C  22
ALA C  31
 None
 0.92A 1oniD-5kn5A:
undetectable
1oniE-5kn5A:
undetectable		 1oniD-5kn5A:
24.06
1oniE-5kn5A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ILE B 337
PRO B 352
GLU B 342
ALA B 346
 None
 1.11A 1oniD-5n8nB:
undetectable
1oniE-5n8nB:
undetectable		 1oniD-5n8nB:
undetectable
1oniE-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no8 BACCELL_00875

(Bacteroides
cellulosilyticus) 		no annotation 4 ILE A 494
PRO A 495
PHE A 459
ALA A 455
 None
 1.06A 1oniD-5no8A:
undetectable
1oniE-5no8A:
undetectable		 1oniD-5no8A:
12.10
1oniE-5no8A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsc UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 365
ILE A  35
GLU A  34
PHE A 348
 None
 1.05A 1oniD-5tscA:
undetectable
1oniE-5tscA:
undetectable		 1oniD-5tscA:
15.22
1oniE-5tscA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 ILE A 782
GLU A 784
ARG A 619
ALA A 614
 None
 1.03A 1oniD-5ue8A:
undetectable
1oniE-5ue8A:
undetectable		 1oniD-5ue8A:
9.05
1oniE-5ue8A:
9.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v4d PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 113
GLU A 119
 None
 0.50A 1oniD-5v4dA:
24.0
1oniE-5v4dA:
24.0		 1oniD-5v4dA:
45.38
1oniE-5v4dA:
45.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 TYR A 475
ILE A 237
PRO A 239
ALA A 248
 None
 1.01A 1oniD-5wroA:
undetectable
1oniE-5wroA:
undetectable		 1oniD-5wroA:
16.36
1oniE-5wroA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 4 ILE A 182
PRO A 185
PHE A 186
ALA A 229
 None
 1.00A 1oniD-6ao5A:
undetectable
1oniE-6ao5A:
undetectable		 1oniD-6ao5A:
18.99
1oniE-6ao5A:
18.99