SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_D_BEZD507_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 PHE A  69
ALA A  38
ILE A  45
GLU A  40
 None
 0.88A 1oniD-1a5cA:
0.0
1oniF-1a5cA:
0.0		 1oniD-1a5cA:
16.90
1oniF-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoc COAGULOGEN

(Tachypleus
tridentatus) 		PF02035
(Coagulin) 		4 PHE A  51
ALA A 116
ILE A  30
GLU A  31
 None
 0.94A 1oniD-1aocA:
undetectable
1oniF-1aocA:
undetectable		 1oniD-1aocA:
19.78
1oniF-1aocA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2r PROTEIN
(TRYPTOPHANYL TRNA
SYNTHETASE)

(Geobacillus
stearothermophilus) 		PF00579
(tRNA-synt_1b) 		4 PHE A  26
ALA A  22
ILE A   8
ILE A  14
 None
 0.86A 1oniD-1d2rA:
0.0
1oniF-1d2rA:
0.0		 1oniD-1d2rA:
18.21
1oniF-1d2rA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 431
ALA B 365
ILE B 396
ILE B 325
 None
 0.83A 1oniD-1ffvB:
0.0
1oniF-1ffvB:
0.0		 1oniD-1ffvB:
11.85
1oniF-1ffvB:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i5a CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c) 		4 PHE A 362
ALA A 436
ILE A 399
ILE A 535
 None
 0.98A 1oniD-1i5aA:
undetectable
1oniF-1i5aA:
undetectable		 1oniD-1i5aA:
24.74
1oniF-1i5aA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kri VP4

(Rotavirus A) 		PF00426
(VP4_haemagglut) 		4 ALA A 104
ILE A 128
TYR A 152
ILE A 141
 None
 0.94A 1oniD-1kriA:
undetectable
1oniF-1kriA:
undetectable		 1oniD-1kriA:
20.97
1oniF-1kriA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		4 PHE A 240
ALA A 224
ILE A 246
ILE A 254
 None
 0.84A 1oniD-1nd4A:
1.9
1oniF-1nd4A:
1.9		 1oniD-1nd4A:
17.06
1oniF-1nd4A:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		4 ALA A  38
ILE A 144
ILE A  29
GLU A  33
 None
 0.91A 1oniD-1ocmA:
0.0
1oniF-1ocmA:
undetectable		 1oniD-1ocmA:
16.63
1oniF-1ocmA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		4 ARG A 383
ALA A 332
ILE A 322
ILE A 272
 None
 0.88A 1oniD-1p49A:
0.2
1oniF-1p49A:
0.2		 1oniD-1p49A:
13.83
1oniF-1p49A:
13.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		4 ILE A  17
TYR A  20
ILE A  36
GLU A 121
 None
 0.55A 1oniD-1qahA:
26.1
1oniF-1qahA:
26.3		 1oniD-1qahA:
87.50
1oniF-1qahA:
87.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcw FLAVOCYTOCHROME B2

(Saccharomyces
cerevisiae) 		PF01070
(FMN_dh) 		4 ARG A 353
ILE A 358
ILE A 394
GLU A 390
 None
 0.81A 1oniD-1qcwA:
undetectable
1oniF-1qcwA:
undetectable		 1oniD-1qcwA:
16.26
1oniF-1qcwA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9d DIAPHANOUS PROTEIN
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2) 		4 PHE A1069
ALA A 922
ILE A 861
ILE A 874
 None
 0.98A 1oniD-1v9dA:
undetectable
1oniF-1v9dA:
undetectable		 1oniD-1v9dA:
18.04
1oniF-1v9dA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjk MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1

(Pyrococcus
furiosus) 		PF02597
(ThiS) 		4 PHE A  45
ALA A  16
ILE A  23
GLU A  21
 None
 0.98A 1oniD-1vjkA:
undetectable
1oniF-1vjkA:
undetectable		 1oniD-1vjkA:
21.09
1oniF-1vjkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlp NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Saccharomyces
cerevisiae) 		PF04095
(NAPRTase) 		5 PHE A 260
ALA A  22
ILE A  17
TYR A  84
ILE A 129
 None
 1.33A 1oniD-1vlpA:
undetectable
1oniF-1vlpA:
undetectable		 1oniD-1vlpA:
16.01
1oniF-1vlpA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1w STRUCTURAL
MAINTENANCE OF
CHROMOSOME 1

(Saccharomyces
cerevisiae) 		PF02463
(SMC_N) 		4 ALA A  45
ILE A1215
TYR A  15
ILE A  31
 None
 0.95A 1oniD-1w1wA:
undetectable
1oniF-1w1wA:
undetectable		 1oniD-1w1wA:
17.95
1oniF-1w1wA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Pyrococcus
furiosus) 		PF00290
(Trp_syntA) 		4 PHE A 138
ALA A 122
ILE A 112
ILE A  92
 None
 0.83A 1oniD-1wdwA:
undetectable
1oniF-1wdwA:
undetectable		 1oniD-1wdwA:
22.08
1oniF-1wdwA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy6 HYPOTHETICAL PROTEIN
ST1625

(Sulfurisphaera
tokodaii) 		PF09205
(DUF1955) 		4 PHE A  46
ALA A  15
ILE A  54
ILE A  24
 None
 0.98A 1oniD-1wy6A:
undetectable
1oniF-1wy6A:
undetectable		 1oniD-1wy6A:
22.41
1oniF-1wy6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 233
ARG A 225
ALA A 224
ILE A 181
 None
 0.96A 1oniD-1xc6A:
undetectable
1oniF-1xc6A:
undetectable		 1oniD-1xc6A:
10.56
1oniF-1xc6A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z69 COENZYME
F420-DEPENDENT
N(5),N(10)-METHYLENE
TETRAHYDROMETHANOPTE
RIN REDUCTASE

(Methanosarcina
barkeri) 		PF00296
(Bac_luciferase) 		4 PHE A 183
ALA A 177
ILE A 303
ILE A 281
 None
 0.94A 1oniD-1z69A:
undetectable
1oniF-1z69A:
undetectable		 1oniD-1z69A:
19.69
1oniF-1z69A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpg GLUCOSE 6-PHOSPHATE
DEHYDROGENASE

(Leuconostoc
mesenteroides) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 PHE A 332
ALA A 249
ILE A 349
ILE A 188
 None
 0.79A 1oniD-2dpgA:
undetectable
1oniF-2dpgA:
1.0		 1oniD-2dpgA:
16.46
1oniF-2dpgA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq5 228AA LONG
HYPOTHETICAL
HYDANTOIN RACEMASE

(Pyrococcus
horikoshii) 		PF01177
(Asp_Glu_race) 		4 ALA A  85
ILE A  41
ILE A  48
GLU A  54
 None
 0.74A 1oniD-2eq5A:
undetectable
1oniF-2eq5A:
undetectable		 1oniD-2eq5A:
21.27
1oniF-2eq5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		4 ARG A 123
ALA A 360
ILE A 354
ILE A 176
 None
 0.98A 1oniD-2hdwA:
1.0
1oniF-2hdwA:
undetectable		 1oniD-2hdwA:
17.98
1oniF-2hdwA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqn PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Helicobacter
pylori) 		PF00486
(Trans_reg_C) 		4 ALA A 156
ILE A 135
TYR A 216
ILE A 191
 None
 0.94A 1oniD-2hqnA:
undetectable
1oniF-2hqnA:
undetectable		 1oniD-2hqnA:
23.45
1oniF-2hqnA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 PHE A 238
ALA A 315
ILE A 189
GLU A 316
 None
 0.91A 1oniD-2hrzA:
undetectable
1oniF-2hrzA:
undetectable		 1oniD-2hrzA:
15.27
1oniF-2hrzA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9e TRIOSEPHOSPHATE
ISOMERASE

(Tenebrio
molitor) 		PF00121
(TIM) 		4 PHE A 143
ALA A 186
ILE A 126
ILE A 205
 None
 0.92A 1oniD-2i9eA:
undetectable
1oniF-2i9eA:
undetectable		 1oniD-2i9eA:
23.67
1oniF-2i9eA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p65 HYPOTHETICAL PROTEIN
PF08_0063

(Plasmodium
falciparum) 		PF00004
(AAA) 		4 PHE A 120
ALA A 158
ILE A  59
ILE A 181
 None
 0.93A 1oniD-2p65A:
undetectable
1oniF-2p65A:
undetectable		 1oniD-2p65A:
23.23
1oniF-2p65A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcu CARBOXYPEPTIDASE A4

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 PHE A 106
ALA A  61
ILE A 183
ILE A 263
 None
 0.98A 1oniD-2pcuA:
undetectable
1oniF-2pcuA:
undetectable		 1oniD-2pcuA:
17.16
1oniF-2pcuA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		4 ALA A 296
ILE A 303
ILE A 250
GLU A 253
 None
 0.98A 1oniD-2pgsA:
undetectable
1oniF-2pgsA:
undetectable		 1oniD-2pgsA:
16.23
1oniF-2pgsA:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 ILE A  14
TYR A  17
ILE A  33
GLU A 120
 None
 0.53A 1oniD-2uykA:
22.2
1oniF-2uykA:
22.3		 1oniD-2uykA:
39.01
1oniF-2uykA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		4 ALA C 190
ILE C 215
ILE C 206
GLU C 202
 None
 0.97A 1oniD-2v3cC:
undetectable
1oniF-2v3cC:
undetectable		 1oniD-2v3cC:
16.12
1oniF-2v3cC:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wqs AGGLUTININ RECEPTOR

(Streptococcus
gordonii) 		PF16364
(Antigen_C) 		4 PHE A1361
ALA A1377
ILE A1369
ILE A1292
 None
 0.93A 1oniD-2wqsA:
undetectable
1oniF-2wqsA:
undetectable		 1oniD-2wqsA:
18.54
1oniF-2wqsA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ycb CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR

(Methanothermobacter
thermautotrophicus) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 PHE A  95
ALA A  76
ILE A 104
ILE A 123
 None
 0.85A 1oniD-2ycbA:
undetectable
1oniF-2ycbA:
undetectable		 1oniD-2ycbA:
12.40
1oniF-2ycbA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		4 ALA A 227
ILE A 218
ILE A 348
GLU A 229
 CA  A1006 (-4.9A)
CA  A1004 (-4.9A)
None
CA  A1006 (-2.2A)
 0.92A 1oniD-2z2xA:
undetectable
1oniF-2z2xA:
1.1		 1oniD-2z2xA:
20.34
1oniF-2z2xA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3af5 PUTATIVE
UNCHARACTERIZED
PROTEIN PH1404

(Pyrococcus
horikoshii) 		PF07521
(RMMBL)
PF10996
(Beta-Casp)
PF16661
(Lactamase_B_6)
PF17214
(KH_7) 		4 PHE A 104
ALA A  85
ILE A 113
ILE A 132
 None
 0.92A 1oniD-3af5A:
undetectable
1oniF-3af5A:
undetectable		 1oniD-3af5A:
12.15
1oniF-3af5A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 ALA B 243
ILE B 231
TYR B 216
ILE B 236
 None
 0.98A 1oniD-3aqcB:
undetectable
1oniF-3aqcB:
undetectable		 1oniD-3aqcB:
17.18
1oniF-3aqcB:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3brq HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ASCG

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 ALA A  61
ILE A  94
ILE A  81
GLU A  64
 None
 0.97A 1oniD-3brqA:
undetectable
1oniF-3brqA:
undetectable		 1oniD-3brqA:
19.86
1oniF-3brqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE

(Burkholderia
pseudomallei) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 PHE A 179
ALA A 207
ILE A 133
ILE A 220
 None
 0.96A 1oniD-3d6bA:
undetectable
1oniF-3d6bA:
undetectable		 1oniD-3d6bA:
16.92
1oniF-3d6bA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da1 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Bacillus
halodurans) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 PHE A 361
ALA A 387
ILE A 369
ILE A  33
 None
 0.94A 1oniD-3da1A:
undetectable
1oniF-3da1A:
undetectable		 1oniD-3da1A:
14.57
1oniF-3da1A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 ALA A 339
ILE A 391
TYR A 324
ILE A 358
 None
 0.95A 1oniD-3eleA:
undetectable
1oniF-3eleA:
undetectable		 1oniD-3eleA:
16.03
1oniF-3eleA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		5 ARG A 409
ALA A 406
ILE A 428
ILE A 403
GLU A 407
 None
None
None
None
CA  A   4 (-2.3A)
 1.48A 1oniD-3evrA:
undetectable
1oniF-3evrA:
undetectable		 1oniD-3evrA:
17.91
1oniF-3evrA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd9 LAMINARIPENTAOSE-PRO
DUCING
BETA-1,3-GULUASE
(LPHASE)

(Streptomyces
matensis) 		PF16483
(Glyco_hydro_64) 		4 ALA A 393
ILE A 116
TYR A 155
ILE A 107
 None
 0.96A 1oniD-3gd9A:
undetectable
1oniF-3gd9A:
undetectable		 1oniD-3gd9A:
17.86
1oniF-3gd9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd8 NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		PF02460
(Patched)
PF12349
(Sterol-sensing)
PF16414
(NPC1_N) 		4 PHE A 590
ALA A 449
ILE A 601
ILE A 563
 None
 0.94A 1oniD-3jd8A:
undetectable
1oniF-3jd8A:
undetectable		 1oniD-3jd8A:
8.18
1oniF-3jd8A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 PHE A 454
ILE A 151
ILE A 250
GLU A 246
 None
 0.86A 1oniD-3kalA:
undetectable
1oniF-3kalA:
undetectable		 1oniD-3kalA:
14.91
1oniF-3kalA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kto RESPONSE REGULATOR
RECEIVER PROTEIN

(Pseudoalteromonas
atlantica) 		PF00072
(Response_reg) 		4 PHE A 111
ALA A  92
ILE A  73
GLU A  62
 None
 0.87A 1oniD-3ktoA:
undetectable
1oniF-3ktoA:
undetectable		 1oniD-3ktoA:
19.21
1oniF-3ktoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 PHE A  61
ALA A  30
ILE A  37
GLU A  32
 None
 0.79A 1oniD-3kx6A:
1.5
1oniF-3kx6A:
undetectable		 1oniD-3kx6A:
20.11
1oniF-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 PHE A  53
ALA A  22
ILE A  29
GLU A  24
 None
None
None
2FP  A 350 ( 4.9A)
 0.89A 1oniD-3mmtA:
1.4
1oniF-3mmtA:
undetectable		 1oniD-3mmtA:
19.88
1oniF-3mmtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mru AMINOACYL-HISTIDINE
DIPEPTIDASE

(Vibrio
alginolyticus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 PHE A  19
ALA A 132
ILE A  40
ILE A  61
 None
 0.96A 1oniD-3mruA:
undetectable
1oniF-3mruA:
undetectable		 1oniD-3mruA:
16.56
1oniF-3mruA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obv PROTEIN DIAPHANOUS
HOMOLOG 1

(Mus musculus) 		PF02181
(FH2)
PF06345
(Drf_DAD) 		4 PHE E1069
ALA E 922
ILE E 861
ILE E 874
 None
 0.96A 1oniD-3obvE:
undetectable
1oniF-3obvE:
undetectable		 1oniD-3obvE:
15.24
1oniF-3obvE:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwu DNA LIGASE

(Aquifex
aeolicus) 		PF09414
(RNA_ligase) 		4 ARG A  97
ILE A  54
TYR A  51
GLU A 129
 ADN  A 501 (-4.2A)
ADN  A 501 ( 4.4A)
ADN  A 501 (-4.7A)
ADN  A 501 (-3.0A)
 0.94A 1oniD-3qwuA:
undetectable
1oniF-3qwuA:
1.9		 1oniD-3qwuA:
16.44
1oniF-3qwuA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw7 NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF09162
(Tap-RNA_bind) 		4 PHE A 152
ALA A 159
ILE A 139
ILE A 189
 None
 0.95A 1oniD-3rw7A:
undetectable
1oniF-3rw7A:
undetectable		 1oniD-3rw7A:
19.91
1oniF-3rw7A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdq ALPHA-BISABOLENE
SYNTHASE

(Abies grandis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ARG A  53
ALA A  56
ILE A 313
ILE A  63
 None
 0.88A 1oniD-3sdqA:
undetectable
1oniF-3sdqA:
undetectable		 1oniD-3sdqA:
11.04
1oniF-3sdqA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqs RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Coxiella
burnetii) 		PF00398
(RrnaAD) 		4 PHE A 250
ALA A 210
ILE A 236
ILE A 226
 None
 0.91A 1oniD-3tqsA:
undetectable
1oniF-3tqsA:
undetectable		 1oniD-3tqsA:
20.65
1oniF-3tqsA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 PHE A 585
ARG A 499
ILE A 583
ILE A 463
 None
 0.85A 1oniD-3v4pA:
undetectable
1oniF-3v4pA:
undetectable		 1oniD-3v4pA:
13.03
1oniF-3v4pA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 PHE A 134
ALA A 103
ILE A 110
GLU A 105
 None
 0.70A 1oniD-4d2jA:
undetectable
1oniF-4d2jA:
undetectable		 1oniD-4d2jA:
17.75
1oniF-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d82 AAA ATPASE, CENTRAL
DOMAIN PROTEIN

(Metallosphaera
sedula) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 PHE A 200
ALA A 246
ILE A 147
ILE A 265
 None
 0.66A 1oniD-4d82A:
undetectable
1oniF-4d82A:
undetectable		 1oniD-4d82A:
18.18
1oniF-4d82A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1o HISTIDINE
DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 PHE A 398
ALA A 471
ILE A 446
ILE A 427
 None
 0.80A 1oniD-4e1oA:
undetectable
1oniF-4e1oA:
undetectable		 1oniD-4e1oA:
15.77
1oniF-4e1oA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		4 PHE A 417
ALA A 484
ILE A 490
ILE A 433
 None
 0.96A 1oniD-4ga6A:
undetectable
1oniF-4ga6A:
undetectable		 1oniD-4ga6A:
14.97
1oniF-4ga6A:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3u ALDEHYDE
DEHYDROGENASE (NAD+)

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 PHE A 113
ALA A 165
ILE A 196
ILE A  87
 None
 0.98A 1oniD-4i3uA:
undetectable
1oniF-4i3uA:
undetectable		 1oniD-4i3uA:
15.05
1oniF-4i3uA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixo NIFS-LIKE PROTEIN

(Rickettsia
africae) 		PF00266
(Aminotran_5) 		4 PHE A 175
ALA A  54
ILE A 207
ILE A  57
 None
 0.88A 1oniD-4ixoA:
undetectable
1oniF-4ixoA:
undetectable		 1oniD-4ixoA:
19.15
1oniF-4ixoA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 PHE A 440
ALA A 479
ILE A 565
ILE A 483
 None
 0.99A 1oniD-4krfA:
1.7
1oniF-4krfA:
2.1		 1oniD-4krfA:
11.71
1oniF-4krfA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 PHE A 203
ALA A 249
ILE A 150
ILE A 268
 None
 0.91A 1oniD-4lgmA:
undetectable
1oniF-4lgmA:
undetectable		 1oniD-4lgmA:
19.59
1oniF-4lgmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		4 PHE A 186
ALA A 106
ILE A  86
ILE A 136
 None
 0.92A 1oniD-4mchA:
undetectable
1oniF-4mchA:
undetectable		 1oniD-4mchA:
18.80
1oniF-4mchA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8a BIFUNCTIONAL PROTEIN
PUTA

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 PHE A 484
ALA A 470
ILE A 480
ILE A 414
 None
 0.95A 1oniD-4o8aA:
undetectable
1oniF-4o8aA:
undetectable		 1oniD-4o8aA:
14.08
1oniF-4o8aA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohq TRIOSEPHOSPHATE
ISOMERASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00121
(TIM) 		4 PHE A 145
ALA A 188
ILE A 128
ILE A 207
 None
 0.87A 1oniD-4ohqA:
undetectable
1oniF-4ohqA:
1.5		 1oniD-4ohqA:
21.10
1oniF-4ohqA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6b EST-Y29

(metagenome) 		PF00144
(Beta-lactamase) 		4 ARG A  89
ALA A 156
ILE A 180
ILE A 109
 None
 0.95A 1oniD-4p6bA:
undetectable
1oniF-4p6bA:
undetectable		 1oniD-4p6bA:
15.54
1oniF-4p6bA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 ALA A 107
ILE A 135
ILE A  72
GLU A 141
 None
 0.94A 1oniD-4qtsA:
undetectable
1oniF-4qtsA:
undetectable		 1oniD-4qtsA:
16.47
1oniF-4qtsA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Clostridioides
difficile) 		PF01520
(Amidase_3) 		4 ARG A 213
ALA A 216
ILE A 258
ILE A 242
 EPE  A 403 (-3.9A)
EPE  A 403 (-3.7A)
None
None
 0.77A 1oniD-4rn7A:
undetectable
1oniF-4rn7A:
undetectable		 1oniD-4rn7A:
24.43
1oniF-4rn7A:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ru0 PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC
BRANCHED-CHAIN AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		4 PHE A  33
ALA A 334
ILE A  61
TYR A  57
 None
 0.98A 1oniD-4ru0A:
undetectable
1oniF-4ru0A:
undetectable		 1oniD-4ru0A:
15.68
1oniF-4ru0A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		PF02706
(Wzz) 		4 PHE A 154
ARG A  64
TYR A 102
ILE A  61
 None
 0.89A 1oniD-4wl1A:
undetectable
1oniF-4wl1A:
undetectable		 1oniD-4wl1A:
18.03
1oniF-4wl1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xiv CHEMOTAXIS PROTEIN
CHEA

(Thermotoga
maritima) 		PF02518
(HATPase_c)
PF02895
(H-kinase_dim) 		4 PHE A 362
ALA A 436
ILE A 399
ILE A 535
 None
 0.95A 1oniD-4xivA:
undetectable
1oniF-4xivA:
undetectable		 1oniD-4xivA:
20.24
1oniF-4xivA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		4 PHE A 477
ALA A 293
ILE A 460
ILE A 271
 None
 0.97A 1oniD-4yjiA:
undetectable
1oniF-4yjiA:
undetectable		 1oniD-4yjiA:
14.98
1oniF-4yjiA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 PHE A 842
ALA A 881
ILE A 900
ILE A 712
 None
 0.84A 1oniD-4yswA:
undetectable
1oniF-4yswA:
undetectable		 1oniD-4yswA:
8.29
1oniF-4yswA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 PHE A1939
ALA A1935
ILE A1949
ILE A1974
 None
 0.99A 1oniD-5cslA:
undetectable
1oniF-5cslA:
undetectable		 1oniD-5cslA:
5.14
1oniF-5cslA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eaw DNA REPLICATION
ATP-DEPENDENT
HELICASE/NUCLEASE
DNA2

(Mus musculus) 		PF08696
(Dna2)
PF13086
(AAA_11)
PF13087
(AAA_12) 		4 PHE A 599
ILE A 596
TYR A 441
GLU A 808
 None
 0.90A 1oniD-5eawA:
undetectable
1oniF-5eawA:
undetectable		 1oniD-5eawA:
9.06
1oniF-5eawA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8p ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO

(Homo sapiens) 		PF12933
(FTO_NTD)
PF12934
(FTO_CTD) 		4 PHE A 139
ALA A  68
ILE A  97
ILE A 132
 None
 0.95A 1oniD-5f8pA:
undetectable
1oniF-5f8pA:
undetectable		 1oniD-5f8pA:
13.59
1oniF-5f8pA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gml GOLGI
REASSEMBLY-STACKING
PROTEIN 2

(Mus musculus) 		PF04495
(GRASP55_65) 		4 ARG A  80
ALA A  82
ILE A  40
ILE A  43
 None
 0.99A 1oniD-5gmlA:
undetectable
1oniF-5gmlA:
undetectable		 1oniD-5gmlA:
20.85
1oniF-5gmlA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4b CEREBELLIN-4

(Mus musculus) 		PF00386
(C1q) 		4 PHE A 115
ALA A 140
ILE A  84
ILE A 126
 None
 0.94A 1oniD-5h4bA:
undetectable
1oniF-5h4bA:
undetectable		 1oniD-5h4bA:
23.43
1oniF-5h4bA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hns NIEMANN-PICK C1
PROTEIN

(Homo sapiens) 		no annotation 4 PHE A 590
ALA A 449
ILE A 601
ILE A 563
 None
 0.94A 1oniD-5hnsA:
undetectable
1oniF-5hnsA:
undetectable		 1oniD-5hnsA:
21.49
1oniF-5hnsA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyh UNCHARACTERIZED
PROTEIN

(Streptomyces
venezuelae) 		PF11583
(AurF) 		4 PHE A 166
ARG A  92
ILE A 284
ILE A  74
 None
 0.91A 1oniD-5hyhA:
undetectable
1oniF-5hyhA:
undetectable		 1oniD-5hyhA:
17.73
1oniF-5hyhA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfm ALDEHYDE
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00171
(Aldedh) 		4 ALA A 387
ILE A 358
TYR A 356
ILE A 394
 None
 0.87A 1oniD-5jfmA:
undetectable
1oniF-5jfmA:
undetectable		 1oniD-5jfmA:
14.40
1oniF-5jfmA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 ALA A 171
ILE A 231
ILE A 198
GLU A 202
 None
 0.92A 1oniD-5jxrA:
undetectable
1oniF-5jxrA:
0.6		 1oniD-5jxrA:
10.97
1oniF-5jxrA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5a PARB DOMAIN PROTEIN
NUCLEASE

(Sulfolobus
solfataricus) 		PF02195
(ParBc) 		4 PHE B  26
ARG B  91
ALA B  94
ILE B 120
 None
 0.98A 1oniD-5k5aB:
undetectable
1oniF-5k5aB:
undetectable		 1oniD-5k5aB:
17.49
1oniF-5k5aB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 PHE A 258
ALA A 283
ILE A 226
ILE A 269
 None
 0.99A 1oniD-5kcaA:
undetectable
1oniF-5kcaA:
undetectable		 1oniD-5kcaA:
11.13
1oniF-5kcaA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 PHE A 400
ALA A 425
ILE A 368
ILE A 411
 None
 0.99A 1oniD-5kcaA:
undetectable
1oniF-5kcaA:
undetectable		 1oniD-5kcaA:
11.13
1oniF-5kcaA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5klp ORF34

(Pseudomonas
syringae) 		PF03421
(Acetyltransf_14) 		4 PHE A 287
ALA A 227
ILE A 205
ILE A 237
 None
 0.87A 1oniD-5klpA:
undetectable
1oniF-5klpA:
undetectable		 1oniD-5klpA:
16.71
1oniF-5klpA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE

(Mycobacterium
tuberculosis) 		PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB) 		4 PHE A 369
ALA A 414
ILE A 302
ILE A 435
 None
 0.95A 1oniD-5kwaA:
undetectable
1oniF-5kwaA:
undetectable		 1oniD-5kwaA:
17.61
1oniF-5kwaA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lun 2-OXOGLUTARATE-DEPEN
DENT
ETHYLENE/SUCCINATE-F
ORMING ENZYME

(Pseudomonas
savastanoi) 		PF03171
(2OG-FeII_Oxy)
PF14226
(DIOX_N) 		4 ARG A 277
ALA A 279
ILE A 186
ILE A  95
 OGA  A 402 (-2.7A)
OGA  A 402 (-3.6A)
ARG  A 403 (-4.7A)
None
 0.79A 1oniD-5lunA:
undetectable
1oniF-5lunA:
undetectable		 1oniD-5lunA:
17.01
1oniF-5lunA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd4 TUBULIN ALPHA CHAIN

(Bos taurus) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 PHE A 169
ALA A 270
ILE A 171
ILE A 209
 None
None
GTP  A 500 ( 4.7A)
None
 0.91A 1oniD-5nd4A:
4.7
1oniF-5nd4A:
4.8		 1oniD-5nd4A:
16.21
1oniF-5nd4A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofu FBP PROTEIN

(Leishmania
major) 		PF00316
(FBPase) 		4 PHE A 322
ALA A 285
ILE A 291
ILE A 135
 None
 0.96A 1oniD-5ofuA:
undetectable
1oniF-5ofuA:
undetectable		 1oniD-5ofuA:
20.85
1oniF-5ofuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufy ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 4 ALA A 446
ILE A 590
TYR A 586
ILE A 456
 None
 0.98A 1oniD-5ufyA:
undetectable
1oniF-5ufyA:
undetectable		 1oniD-5ufyA:
21.68
1oniF-5ufyA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ug1 ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 4 ALA A 446
ILE A 590
TYR A 586
ILE A 456
 None
 0.98A 1oniD-5ug1A:
undetectable
1oniF-5ug1A:
undetectable		 1oniD-5ug1A:
22.87
1oniF-5ug1A:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v4d PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		4 ILE A  14
TYR A  17
ILE A  33
GLU A 119
 None
 0.40A 1oniD-5v4dA:
24.0
1oniF-5v4dA:
24.2		 1oniD-5v4dA:
45.38
1oniF-5v4dA:
45.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc1 MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		PF00004
(AAA) 		4 PHE A 290
ALA A 338
ILE A 242
ILE A 357
 None
 0.73A 1oniD-5wc1A:
undetectable
1oniF-5wc1A:
undetectable		 1oniD-5wc1A:
15.60
1oniF-5wc1A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdi UBIQUITIN-ASSOCIATED
AND SH3
DOMAIN-CONTAINING
PROTEIN A

(Homo sapiens) 		PF00300
(His_Phos_1) 		4 PHE A 547
ALA A 567
ILE A 511
ILE A 572
 None
 0.95A 1oniD-5wdiA:
undetectable
1oniF-5wdiA:
undetectable		 1oniD-5wdiA:
19.46
1oniF-5wdiA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 PHE A 442
ALA A 481
ILE A 567
ILE A 485
 None
 0.93A 1oniD-5weaA:
1.5
1oniF-5weaA:
undetectable		 1oniD-5weaA:
10.48
1oniF-5weaA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xom GLYCOSAMINOGLYCAN
XYLOSYLKINASE

(Hydra vulgaris) 		no annotation 4 PHE A 208
ALA A 118
ILE A 180
ILE A 104
 None
 0.97A 1oniD-5xomA:
undetectable
1oniF-5xomA:
undetectable		 1oniD-5xomA:
undetectable
1oniF-5xomA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 4 PHE A 282
ALA A 315
ILE A 221
ILE A 338
 None
 0.82A 1oniD-6amnA:
undetectable
1oniF-6amnA:
undetectable		 1oniD-6amnA:
undetectable
1oniF-6amnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5d MEIOTIC SPINDLE
FORMATION PROTEIN
MEI-1

(Caenorhabditis
elegans) 		no annotation 4 PHE A 290
ALA A 338
ILE A 242
ILE A 357
 None
 0.71A 1oniD-6b5dA:
undetectable
1oniF-6b5dA:
undetectable		 1oniD-6b5dA:
undetectable
1oniF-6b5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epd 26S PROTEASOME
SUBUNIT S5A

(Rattus
norvegicus) 		no annotation 4 ARG W 100
ALA W  96
ILE W 109
ILE W  52
 None
 0.99A 1oniD-6epdW:
undetectable
1oniF-6epdW:
undetectable		 1oniD-6epdW:
undetectable
1oniF-6epdW:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 4 PHE D 296
ALA D 326
ILE D  86
ILE D 356
 None
 0.99A 1oniD-6fmlD:
undetectable
1oniF-6fmlD:
undetectable		 1oniD-6fmlD:
undetectable
1oniF-6fmlD:
undetectable