SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_C_BEZC505

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		4 TYR A 170
ILE A 192
GLU A 195
PHE A 185
 None
 1.16A 1oniA-1abrA:
undetectable
1oniC-1abrA:
undetectable		 1oniA-1abrA:
21.03
1oniC-1abrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1abr ABRIN-A

(Abrus
precatorius) 		PF00161
(RIP) 		4 TYR A 170
ILE A 192
PRO A 187
GLU A 195
 None
 1.36A 1oniA-1abrA:
undetectable
1oniC-1abrA:
undetectable		 1oniA-1abrA:
21.03
1oniC-1abrA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aha ALPHA-MOMORCHARIN

(Momordica
charantia) 		PF00161
(RIP) 		4 TYR A 166
ILE A 186
PRO A 181
GLU A 189
 None
 1.45A 1oniA-1ahaA:
undetectable
1oniC-1ahaA:
undetectable		 1oniA-1ahaA:
21.14
1oniC-1ahaA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		4 ILE A  13
GLU A 201
PHE A 123
ARG A 119
 None
 1.16A 1oniA-1j31A:
undetectable
1oniC-1j31A:
undetectable		 1oniA-1j31A:
17.36
1oniC-1j31A:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j7h HYPOTHETICAL PROTEIN
HI0719

(Haemophilus
influenzae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 116
GLU A 122
 None
 0.58A 1oniA-1j7hA:
19.0
1oniC-1j7hA:
18.9		 1oniA-1j7hA:
42.96
1oniC-1j7hA:
42.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd1 HYPOTHETICAL 13.9
KDA PROTEIN IN
FCY2-PET117
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 114
GLU A 120
 None
 0.57A 1oniA-1jd1A:
22.4
1oniC-1jd1A:
23.0		 1oniA-1jd1A:
38.64
1oniC-1jd1A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 PRO A 587
GLU A 477
PHE A 619
ARG A 438
 None
 1.46A 1oniA-1k1xA:
undetectable
1oniC-1k1xA:
undetectable		 1oniA-1k1xA:
12.75
1oniC-1k1xA:
12.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oni 14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN

(Homo sapiens) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  21
ILE A  37
PRO A 116
GLU A 122
 None
 0.01A 1oniA-1oniA:
29.1
1oniC-1oniA:
26.6		 1oniA-1oniA:
100.00
1oniC-1oniA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 115
GLU A 121
 None
 0.29A 1oniA-1qahA:
25.7
1oniC-1qahA:
26.5		 1oniA-1qahA:
87.50
1oniC-1qahA:
87.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qd9 PURINE REGULATORY
PROTEIN YABJ

(Bacillus
subtilis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 111
GLU A 117
 None
 0.29A 1oniA-1qd9A:
23.3
1oniC-1qd9A:
23.2		 1oniA-1qd9A:
42.22
1oniC-1qd9A:
42.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.37A 1oniA-1qu9A:
22.1
1oniC-1qu9A:
21.8		 1oniA-1qu9A:
44.78
1oniC-1qu9A:
44.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8x MALTOSE-6'-PHOSPHATE
GLUCOSIDASE

(Bacillus
subtilis) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ILE X  50
PRO X  19
PHE X  17
ARG X 293
 None
None
NAD  X 900 (-4.2A)
NAD  X 900 ( 3.8A)
 1.40A 1oniA-1u8xX:
undetectable
1oniC-1u8xX:
undetectable		 1oniA-1u8xX:
16.04
1oniC-1u8xX:
16.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811

(Sulfurisphaera
tokodaii) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.28A 1oniA-1x25A:
24.1
1oniC-1x25A:
24.1		 1oniA-1x25A:
43.61
1oniC-1x25A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY

(Ruminiclostridium
thermocellum) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.46A 1oniA-1xrgA:
24.0
1oniC-1xrgA:
23.9		 1oniA-1xrgA:
44.52
1oniC-1xrgA:
44.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvy SFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		4 TYR A 215
ILE A 192
PRO A 197
PHE A 198
 None
 1.37A 1oniA-1xvyA:
undetectable
1oniC-1xvyA:
undetectable		 1oniA-1xvyA:
20.13
1oniC-1xvyA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zip ADENYLATE KINASE

(Geobacillus
stearothermophilus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 TYR A  24
ILE A 111
PHE A 205
ARG A 209
 None
 1.50A 1oniA-1zipA:
undetectable
1oniC-1zipA:
undetectable		 1oniA-1zipA:
20.54
1oniC-1zipA:
20.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b33 PROTEIN SYNTHESIS
INHIBITOR, PUTATIVE

(Thermotoga
maritima) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 112
GLU A 118
 None
 0.27A 1oniA-2b33A:
23.4
1oniC-2b33A:
23.1		 1oniA-2b33A:
42.14
1oniC-2b33A:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cvl PROTEIN TRANSLATION
INITIATION INHIBITOR

(Thermus
thermophilus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  16
ILE A  32
PRO A 110
GLU A 116
 None
 0.68A 1oniA-2cvlA:
22.5
1oniC-2cvlA:
22.7		 1oniA-2cvlA:
40.15
1oniC-2cvlA:
40.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eid GALACTOSE OXIDASE

(Fusarium
graminearum) 		PF00754
(F5_F8_type_C)
PF01344
(Kelch_1)
PF09118
(DUF1929) 		4 TYR A  88
ILE A 129
PRO A  52
ARG A 125
 None
 1.27A 1oniA-2eidA:
undetectable
1oniC-2eidA:
undetectable		 1oniA-2eidA:
13.83
1oniC-2eidA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fwr DNA REPAIR PROTEIN
RAD25

(Archaeoglobus
fulgidus) 		PF04851
(ResIII)
PF16203
(ERCC3_RAD25_C) 		4 ILE A  65
GLU A  66
PHE A 220
ARG A 298
 None
 1.25A 1oniA-2fwrA:
undetectable
1oniC-2fwrA:
undetectable		 1oniA-2fwrA:
16.45
1oniC-2fwrA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ILE A 218
PRO A 156
GLU A 217
ARG A 213
 None
None
None
SO4  A 410 (-3.0A)
 1.07A 1oniA-2g17A:
undetectable
1oniC-2g17A:
undetectable		 1oniA-2g17A:
19.53
1oniC-2g17A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiv THERMOSTABLE DNA
LIGASE

(Sulfolobus
solfataricus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		4 ILE A 504
GLU A 524
PHE A 479
ARG A 512
 None
 1.04A 1oniA-2hivA:
undetectable
1oniC-2hivA:
undetectable		 1oniA-2hivA:
13.06
1oniC-2hivA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf3 ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		4 TYR A 219
ILE A 261
PRO A 182
PHE A 249
 None
 1.34A 1oniA-2jf3A:
undetectable
1oniC-2jf3A:
undetectable		 1oniA-2jf3A:
19.40
1oniC-2jf3A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jh9 VP4 CORE PROTEIN

(Bluetongue
virus) 		PF05059
(Orbi_VP4) 		4 ILE A 166
PRO A 158
PHE A 170
ARG A 378
 None
 1.50A 1oniA-2jh9A:
undetectable
1oniC-2jh9A:
undetectable		 1oniA-2jh9A:
12.85
1oniC-2jh9A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lop TRANSMEMBRANE
PROTEIN 14A

(Homo sapiens) 		PF03647
(Tmemb_14) 		4 ILE A  77
PRO A  79
PHE A  71
ARG A  73
 None
 1.37A 1oniA-2lopA:
undetectable
1oniC-2lopA:
undetectable		 1oniA-2lopA:
25.69
1oniC-2lopA:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpm TWO-COMPONENT
RESPONSE REGULATOR

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		4 TYR A  69
ILE A  20
GLU A  15
PHE A  84
 None
 1.26A 1oniA-2lpmA:
undetectable
1oniC-2lpmA:
undetectable		 1oniA-2lpmA:
23.61
1oniC-2lpmA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ool SENSOR PROTEIN

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		4 TYR A 308
PRO A 229
GLU A 315
ARG A 311
 None
 1.37A 1oniA-2oolA:
undetectable
1oniC-2oolA:
undetectable		 1oniA-2oolA:
17.12
1oniC-2oolA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqa LUFFACULIN 1

(Luffa
acutangula) 		PF00161
(RIP) 		4 TYR A 165
ILE A 185
PRO A 180
GLU A 188
 None
 1.44A 1oniA-2oqaA:
undetectable
1oniC-2oqaA:
undetectable		 1oniA-2oqaA:
21.79
1oniC-2oqaA:
21.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.44A 1oniA-2uykA:
22.0
1oniC-2uykA:
22.3		 1oniA-2uykA:
39.01
1oniC-2uykA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA

(Rattus
norvegicus;
Homo sapiens) 		PF01602
(Adaptin_N)
PF01602
(Adaptin_N) 		4 TYR B 524
ILE A 470
GLU A 506
ARG B 528
 None
 1.29A 1oniA-2xa7B:
undetectable
1oniC-2xa7B:
undetectable		 1oniA-2xa7B:
12.28
1oniC-2xa7B:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		4 ILE A 370
PRO A 383
GLU A 371
PHE A 387
 None
 1.27A 1oniA-2xh1A:
undetectable
1oniC-2xh1A:
undetectable		 1oniA-2xh1A:
16.00
1oniC-2xh1A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zai OLIGOSACCHARYL
TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 4 ILE A 720
PRO A 712
GLU A 715
PHE A 707
 None
 1.40A 1oniA-2zaiA:
undetectable
1oniC-2zaiA:
undetectable		 1oniA-2zaiA:
16.27
1oniC-2zaiA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auf GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE 1

(Symbiobacterium
toebii) 		PF00551
(Formyl_trans_N) 		4 ILE A 108
PRO A 110
GLU A 174
ARG A 167
 None
 1.37A 1oniA-3aufA:
undetectable
1oniC-3aufA:
undetectable		 1oniA-3aufA:
21.55
1oniC-3aufA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		4 TYR A 364
PRO A 150
PHE A 395
ARG A 404
 None
 1.30A 1oniA-3ei8A:
undetectable
1oniC-3ei8A:
undetectable		 1oniA-3ei8A:
18.10
1oniC-3ei8A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		4 TYR A  92
PRO A 438
GLU A 442
ARG A  66
 None
 1.46A 1oniA-3gwfA:
undetectable
1oniC-3gwfA:
undetectable		 1oniA-3gwfA:
15.24
1oniC-3gwfA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h35 UNCHARACTERIZED
PROTEIN ABO_0056

(Alcanivorax
borkumensis) 		no annotation 4 ILE A 155
GLU A 134
PHE A 122
ARG A 127
 None
 1.21A 1oniA-3h35A:
undetectable
1oniC-3h35A:
undetectable		 1oniA-3h35A:
25.00
1oniC-3h35A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j0k DNA-DIRECTED RNA
POLYMERASES I, II,
AND III 23 KDA
POLYPEPTIDE
DNA-DIRECTED RNA
POLYMERASE II 19 KDA
POLYPEPTIDE

(Homo sapiens;
Homo sapiens) 		PF01192
(RNA_pol_Rpb6)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 ILE F 130
PRO F 131
GLU F 124
PHE G  18
 None
 1.38A 1oniA-3j0kF:
undetectable
1oniC-3j0kF:
undetectable		 1oniA-3j0kF:
20.28
1oniC-3j0kF:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2s COAGULATION FACTOR
VIII LIGHT CHAIN

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		4 ILE B1700
PRO B1761
GLU B1737
ARG B1764
 None
 1.32A 1oniA-3j2sB:
undetectable
1oniC-3j2sB:
undetectable		 1oniA-3j2sB:
13.18
1oniC-3j2sB:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 TYR A1695
ILE A1359
PRO A1360
ARG A1568
 None
 1.42A 1oniA-3jb9A:
undetectable
1oniC-3jb9A:
undetectable		 1oniA-3jb9A:
4.70
1oniC-3jb9A:
4.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k0t ENDORIBONUCLEASE
L-PSP, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 112
GLU A 118
 BGC  A 127 (-3.1A)
BGC  A 127 (-4.0A)
None
BGC  A 127 (-3.5A)
 0.31A 1oniA-3k0tA:
23.1
1oniC-3k0tA:
23.3		 1oniA-3k0tA:
40.94
1oniC-3k0tA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki8 BETA
UREIDOPROPIONASE
(BETA-ALANINE
SYNTHASE)

(Pyrococcus
abyssi) 		PF00795
(CN_hydrolase) 		4 ILE A  13
GLU A 201
PHE A 123
ARG A 119
 None
 1.17A 1oniA-3ki8A:
undetectable
1oniC-3ki8A:
undetectable		 1oniA-3ki8A:
21.83
1oniC-3ki8A:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mqw PUTATIVE
ENDORIBONUCLEASE
L-PSP

(Entamoeba
histolytica) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 FLC  A 140 (-4.0A)
FLC  A 140 (-4.8A)
FLC  A 140 (-4.5A)
FLC  A 140 (-2.8A)
 0.32A 1oniA-3mqwA:
23.0
1oniC-3mqwA:
22.8		 1oniA-3mqwA:
42.75
1oniC-3mqwA:
42.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1

(Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 TYR A 771
ILE A 919
PRO A 778
GLU A 779
 None
 1.35A 1oniA-3n23A:
undetectable
1oniC-3n23A:
undetectable		 1oniA-3n23A:
8.50
1oniC-3n23A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nva CTP SYNTHASE

(Sulfolobus
solfataricus) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ILE A 312
PRO A 358
GLU A 513
ARG A 465
 None
 1.22A 1oniA-3nvaA:
undetectable
1oniC-3nvaA:
undetectable		 1oniA-3nvaA:
15.78
1oniC-3nvaA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 ILE A  95
PRO A 165
GLU A 109
PHE A 162
 None
 1.35A 1oniA-3prlA:
undetectable
1oniC-3prlA:
undetectable		 1oniA-3prlA:
17.49
1oniC-3prlA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 TYR A 288
ILE A  95
GLU A 109
PHE A 162
 None
 1.37A 1oniA-3prlA:
undetectable
1oniC-3prlA:
undetectable		 1oniA-3prlA:
17.49
1oniC-3prlA:
17.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quw PROTEIN MMF1

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  36
ILE A  52
PRO A 130
GLU A 136
 None
 0.24A 1oniA-3quwA:
22.5
1oniC-3quwA:
22.5		 1oniA-3quwA:
32.68
1oniC-3quwA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0p L-PSP PUTATIVE
ENDORIBONUCLEASE

(uncultured
organism) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 None
 0.34A 1oniA-3r0pA:
23.4
1oniC-3r0pA:
23.4		 1oniA-3r0pA:
43.18
1oniC-3r0pA:
43.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		4 TYR A 335
ILE A 357
GLU A 340
ARG A 338
 None
 1.33A 1oniA-3t5tA:
undetectable
1oniC-3t5tA:
undetectable		 1oniA-3t5tA:
14.75
1oniC-3t5tA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		4 TYR A  72
ILE A  38
GLU A  76
PHE A 163
 None
 1.40A 1oniA-3t8jA:
undetectable
1oniC-3t8jA:
undetectable		 1oniA-3t8jA:
18.45
1oniC-3t8jA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		no annotation 4 TYR A 222
ILE A 153
PRO A 258
GLU A 165
 None
 1.44A 1oniA-3tdgA:
undetectable
1oniC-3tdgA:
undetectable		 1oniA-3tdgA:
22.22
1oniC-3tdgA:
22.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vcz ENDORIBONUCLEASE
L-PSP

(Vibrio
vulnificus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 115
GLU A 121
 None
 0.35A 1oniA-3vczA:
21.5
1oniC-3vczA:
21.5		 1oniA-3vczA:
37.01
1oniC-3vczA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 ILE A 289
PRO A 278
GLU A 292
ARG A 655
 None
 1.30A 1oniA-3x1lA:
undetectable
1oniC-3x1lA:
undetectable		 1oniA-3x1lA:
13.58
1oniC-3x1lA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi1 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		no annotation 4 TYR A 177
ILE A 253
PHE A  -2
ARG A   4
 None
 1.47A 1oniA-3zi1A:
undetectable
1oniC-3zi1A:
undetectable		 1oniA-3zi1A:
17.82
1oniC-3zi1A:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		4 TYR B1771
ILE B1459
PRO B1465
GLU B1468
 None
 1.41A 1oniA-4f92B:
undetectable
1oniC-4f92B:
undetectable		 1oniA-4f92B:
6.15
1oniC-4f92B:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 121
PRO A 122
PHE A 228
ARG A 303
 None
 1.37A 1oniA-4hnlA:
2.0
1oniC-4hnlA:
undetectable		 1oniA-4hnlA:
18.16
1oniC-4hnlA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ILE A 245
PRO A 268
PHE A 265
ARG A 262
 None
 1.32A 1oniA-4ip4A:
undetectable
1oniC-4ip4A:
undetectable		 1oniA-4ip4A:
17.75
1oniC-4ip4A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxr PPE41
ESPG5

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF00823
(PPE)
PF14011
(ESX-1_EspG) 		4 ILE B 109
PRO B   8
GLU B   9
ARG C 109
 None
 1.39A 1oniA-4kxrB:
undetectable
1oniC-4kxrB:
undetectable		 1oniA-4kxrB:
19.79
1oniC-4kxrB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		4 PRO A 562
GLU A 564
PHE A 929
ARG A1008
 None
 1.32A 1oniA-4mt1A:
undetectable
1oniC-4mt1A:
undetectable		 1oniA-4mt1A:
8.14
1oniC-4mt1A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 TYR A 145
ILE A  56
PRO A 428
GLU A 189
 None
 1.36A 1oniA-4n5cA:
undetectable
1oniC-4n5cA:
undetectable		 1oniA-4n5cA:
10.42
1oniC-4n5cA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Chaetomium
thermophilum) 		PF08662
(eIF2A) 		4 PRO A 190
GLU A 622
PHE A 182
ARG A 175
 None
 1.32A 1oniA-4noxA:
undetectable
1oniC-4noxA:
undetectable		 1oniA-4noxA:
11.11
1oniC-4noxA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r70 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB2

(Rhodopseudomonas
palustris) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 TYR A 308
PRO A 229
GLU A 315
ARG A 311
 None
 1.26A 1oniA-4r70A:
undetectable
1oniC-4r70A:
undetectable		 1oniA-4r70A:
13.26
1oniC-4r70A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		4 ILE A 289
PRO A 278
GLU A 292
ARG A 655
 None
 1.30A 1oniA-4w8yA:
undetectable
1oniC-4w8yA:
undetectable		 1oniA-4w8yA:
11.49
1oniC-4w8yA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl1 LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		PF02706
(Wzz) 		4 TYR A 102
ILE A  61
PHE A 154
ARG A  64
 None
 0.91A 1oniA-4wl1A:
undetectable
1oniC-4wl1A:
undetectable		 1oniA-4wl1A:
18.03
1oniC-4wl1A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymg PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE

(Podospora
anserina) 		PF01596
(Methyltransf_3) 		4 TYR A  78
ILE A  58
PRO A  28
GLU A  85
 None
 1.34A 1oniA-4ymgA:
undetectable
1oniC-4ymgA:
undetectable		 1oniA-4ymgA:
20.92
1oniC-4ymgA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zz7 METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Oceanimonas
doudoroffii) 		PF00171
(Aldedh) 		4 ILE A  86
PRO A 151
GLU A 100
PHE A 148
 None
None
None
NAD  A 501 (-4.1A)
 1.31A 1oniA-4zz7A:
undetectable
1oniC-4zz7A:
undetectable		 1oniA-4zz7A:
16.34
1oniC-4zz7A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		4 TYR A 354
ILE A 287
GLU A 285
PHE A 296
 None
None
BG6  A 550 (-2.6A)
None
 1.44A 1oniA-5aq1A:
undetectable
1oniC-5aq1A:
undetectable		 1oniA-5aq1A:
13.88
1oniC-5aq1A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aw4 NA, K-ATPASE ALPHA
SUBUNIT

(Squalus
acanthias) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase) 		4 TYR A 778
ILE A 926
PRO A 785
GLU A 786
 None
None
None
K  A2005 ( 3.6A)
 1.31A 1oniA-5aw4A:
undetectable
1oniC-5aw4A:
undetectable		 1oniA-5aw4A:
9.99
1oniC-5aw4A:
9.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd4 TRANSCRIPTIONAL
REGULATOR ARAR

(Bacteroides
thetaiotaomicron) 		PF00293
(NUDIX) 		4 ILE A 151
PRO A 150
GLU A 149
ARG A 218
 None
 1.30A 1oniA-5dd4A:
undetectable
1oniC-5dd4A:
undetectable		 1oniA-5dd4A:
21.14
1oniC-5dd4A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e53 CONTACTIN-1

(Gallus gallus) 		PF00041
(fn3) 		4 PRO A 739
GLU A 742
PHE A 737
ARG A 746
 None
 1.44A 1oniA-5e53A:
undetectable
1oniC-5e53A:
undetectable		 1oniA-5e53A:
20.20
1oniC-5e53A:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron;
Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2)
PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 TYR A  58
PRO B 615
GLU A  37
PHE B 616
 None
 1.24A 1oniA-5fq6A:
undetectable
1oniC-5fq6A:
undetectable		 1oniA-5fq6A:
14.59
1oniC-5fq6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fvd NUCLEOCAPSID

(Human
metapneumovirus) 		PF03246
(Pneumo_ncap) 		4 TYR A 198
ILE A 146
PRO A 147
ARG A 197
 None
 1.33A 1oniA-5fvdA:
undetectable
1oniC-5fvdA:
undetectable		 1oniA-5fvdA:
16.94
1oniC-5fvdA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 TYR A 138
ILE A 130
GLU A  65
PHE A 157
 None
 1.24A 1oniA-5iq0A:
undetectable
1oniC-5iq0A:
undetectable		 1oniA-5iq0A:
18.54
1oniC-5iq0A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB6
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB7

(Homo sapiens;
Homo sapiens) 		PF01192
(RNA_pol_Rpb6)
PF00575
(S1)
PF03876
(SHS2_Rpb7-N) 		4 ILE F 102
PRO F 103
GLU F  96
PHE G  18
 None
 1.14A 1oniA-5iy9F:
undetectable
1oniC-5iy9F:
undetectable		 1oniA-5iy9F:
19.35
1oniC-5iy9F:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5a PARB DOMAIN PROTEIN
NUCLEASE

(Sulfolobus
solfataricus) 		PF02195
(ParBc) 		4 ILE B 201
GLU B 159
PHE B 223
ARG B 194
 None
 1.31A 1oniA-5k5aB:
undetectable
1oniC-5k5aB:
undetectable		 1oniA-5k5aB:
17.49
1oniC-5k5aB:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m10 CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE

(Thermocrispum
municipale) 		PF07992
(Pyr_redox_2) 		4 TYR A  92
PRO A 438
GLU A 442
ARG A  66
 None
 1.46A 1oniA-5m10A:
undetectable
1oniC-5m10A:
undetectable		 1oniA-5m10A:
13.12
1oniC-5m10A:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 TYR A 522
ILE A 504
PRO A 539
PHE A 454
 None
 1.25A 1oniA-5t88A:
undetectable
1oniC-5t88A:
undetectable		 1oniA-5t88A:
12.50
1oniC-5t88A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsc UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 TYR A 365
ILE A  35
GLU A  34
PHE A 348
 None
 1.14A 1oniA-5tscA:
undetectable
1oniC-5tscA:
undetectable		 1oniA-5tscA:
15.22
1oniC-5tscA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utt SORTASE

(Actinomyces
oris) 		PF04203
(Sortase) 		4 TYR A 105
ILE A 169
PRO A 247
GLU A 167
 None
 1.29A 1oniA-5uttA:
undetectable
1oniC-5uttA:
undetectable		 1oniA-5uttA:
19.69
1oniC-5uttA:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v4d PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 113
GLU A 119
 None
 0.46A 1oniA-5v4dA:
23.6
1oniC-5v4dA:
24.1		 1oniA-5v4dA:
45.38
1oniC-5v4dA:
45.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 4 ILE A 287
PRO A 265
GLU A 268
PHE A 263
 None
 1.40A 1oniA-6bbpA:
undetectable
1oniC-6bbpA:
undetectable		 1oniA-6bbpA:
undetectable
1oniC-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT
PARTICULATE METHANE
MONOOXYGENASE, A
SUBUNIT

(Methylomicrobium
alcaliphilum;
Methylomicrobium
alcaliphilum) 		no annotation
no annotation 		4 TYR B 186
ILE A 105
PHE A  88
ARG A 100
 None
 1.46A 1oniA-6cxhB:
undetectable
1oniC-6cxhB:
undetectable		 1oniA-6cxhB:
undetectable
1oniC-6cxhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eno DEHYDRATASE FAMILY
PROTEIN

(Carboxydothermus
hydrogenoformans) 		no annotation 4 ILE A 207
PRO A 245
GLU A  80
PHE A 248
 None
 1.49A 1oniA-6enoA:
undetectable
1oniC-6enoA:
undetectable		 1oniA-6enoA:
undetectable
1oniC-6enoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC2
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		4 ILE F 130
PRO F 131
GLU F 124
PHE G  18
 None
 1.22A 1oniA-6f42F:
undetectable
1oniC-6f42F:
undetectable		 1oniA-6f42F:
undetectable
1oniC-6f42F:
undetectable