SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_B_BEZB504_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amu GRAMICIDIN
SYNTHETASE 1

(Brevibacillus
brevis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 110
ILE A 106
ALA A 185
ILE A 330
 None
None
None
PHE  A 566 (-4.6A)
 0.96A 1oniB-1amuA:
0.0
1oniC-1amuA:
0.0		 1oniB-1amuA:
14.59
1oniC-1amuA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eco ERYTHROCRUORIN
(CARBONMONOXY)

(Chironomus
thummi) 		PF00042
(Globin) 		4 ILE A  34
PHE A 100
ALA A  30
ILE A  23
 HEM  A 137 (-4.2A)
HEM  A 137 (-3.5A)
None
None
 0.92A 1oniB-1ecoA:
undetectable
1oniC-1ecoA:
undetectable		 1oniB-1ecoA:
23.03
1oniC-1ecoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eio ILEAL LIPID BINDING
PROTEIN

(Sus scrofa) 		PF14651
(Lipocalin_7) 		4 LEU A 108
ILE A 103
ALA A 101
ILE A  65
 None
None
GCH  A 128 ( 4.2A)
None
 0.95A 1oniB-1eioA:
0.0
1oniC-1eioA:
0.0		 1oniB-1eioA:
18.06
1oniC-1eioA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elj MALTODEXTRIN-BINDING
PROTEIN

(Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		4 LEU A 368
ILE A 364
ALA A 351
ILE A 158
 None
 0.73A 1oniB-1eljA:
0.0
1oniC-1eljA:
0.0		 1oniB-1eljA:
15.75
1oniC-1eljA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h79 ANAEROBIC
RIBONUCLEOTIDE-TRIPH
OSPHATE REDUCTASE
LARGE CHAIN

(Escherichia
virus T4) 		PF13597
(NRDD) 		4 ILE A 278
PHE A 293
ALA A 500
ILE A 505
 None
 0.81A 1oniB-1h79A:
1.3
1oniC-1h79A:
1.2		 1oniB-1h79A:
13.75
1oniC-1h79A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		4 LEU A 578
ILE A 564
ALA A 610
ILE A 607
 None
 0.66A 1oniB-1ijqA:
undetectable
1oniC-1ijqA:
0.0		 1oniB-1ijqA:
18.37
1oniC-1ijqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jp4 3'(2'),5'-BISPHOSPHA
TE NUCLEOTIDASE

(Rattus
norvegicus) 		PF00459
(Inositol_P) 		4 LEU A  62
ILE A  58
ALA A  15
ILE A 150
 None
 1.00A 1oniB-1jp4A:
0.0
1oniC-1jp4A:
undetectable		 1oniB-1jp4A:
19.68
1oniC-1jp4A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 LEU A 141
ILE A 142
PHE A 145
ALA A 108
 None
 0.95A 1oniB-1k6mA:
0.0
1oniC-1k6mA:
0.0		 1oniB-1k6mA:
14.91
1oniC-1k6mA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 LEU B 181
ILE B 155
ALA B 125
ILE B  96
 None
 0.87A 1oniB-1nzyB:
0.7
1oniC-1nzyB:
0.1		 1oniB-1nzyB:
19.85
1oniC-1nzyB:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p75 THYMIDINE KINASE

(Equid
alphaherpesvirus
4) 		PF00693
(Herpes_TK) 		4 LEU A 308
ILE A  36
ALA A 306
ILE A 179
 None
T5A  A 501 (-4.5A)
None
None
 0.76A 1oniB-1p75A:
0.0
1oniC-1p75A:
0.0		 1oniB-1p75A:
20.56
1oniC-1p75A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1o CELL DIVISION
CONTROL PROTEIN 24

(Saccharomyces
cerevisiae) 		PF00564
(PB1) 		4 LEU A 841
ILE A 762
ALA A 837
ILE A 816
 None
 0.61A 1oniB-1q1oA:
undetectable
1oniC-1q1oA:
undetectable		 1oniB-1q1oA:
17.39
1oniC-1q1oA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgt PROTEIN (HBV CAPSID
PROTEIN)

(Hepatitis B
virus) 		no annotation 4 LEU C 140
ILE C 139
ILE C 126
PRO C 138
 None
 0.96A 1oniB-1qgtC:
undetectable
1oniC-1qgtC:
undetectable		 1oniB-1qgtC:
23.03
1oniC-1qgtC:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu4 ORNITHINE
DECARBOXYLASE

(Trypanosoma
brucei) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 108
PHE A  65
ALA A 111
ILE A 231
 None
None
PLP  A 600 ( 4.7A)
None
 0.89A 1oniB-1qu4A:
1.4
1oniC-1qu4A:
1.3		 1oniB-1qu4A:
16.46
1oniC-1qu4A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wlh GELATION FACTOR

(Dictyostelium
discoideum) 		PF00630
(Filamin) 		4 LEU A 795
ILE A 786
ALA A 807
ILE A 828
 None
 0.98A 1oniB-1wlhA:
undetectable
1oniC-1wlhA:
undetectable		 1oniB-1wlhA:
22.01
1oniC-1wlhA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6j L-LACTATE
DEHYDROGENASE

(Ruminiclostridium
thermocellum) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ILE A 175
ALA A 217
ILE A 197
PRO A 185
 None
 0.89A 1oniB-1y6jA:
1.0
1oniC-1y6jA:
undetectable		 1oniB-1y6jA:
19.75
1oniC-1y6jA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6w PENICILLIN-BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		4 LEU B 421
ALA B 424
ILE B 465
PRO B 432
 None
 0.95A 1oniB-2c6wB:
undetectable
1oniC-2c6wB:
undetectable		 1oniB-2c6wB:
17.36
1oniC-2c6wB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbz MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 LEU A 661
ILE A 664
ALA A 690
ILE A 823
 None
 0.90A 1oniB-2cbzA:
undetectable
1oniC-2cbzA:
undetectable		 1oniB-2cbzA:
22.69
1oniC-2cbzA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8b TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		4 LEU A  37
ILE A 129
ALA A  33
ILE A  52
 None
 0.86A 1oniB-2d8bA:
undetectable
1oniC-2d8bA:
undetectable		 1oniB-2d8bA:
20.31
1oniC-2d8bA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dvz PUTATIVE EXPORTED
PROTEIN

(Bordetella
pertussis) 		PF03401
(TctC) 		4 LEU A 209
ILE A 204
ILE A  35
PRO A 202
 None
 0.94A 1oniB-2dvzA:
undetectable
1oniC-2dvzA:
undetectable		 1oniB-2dvzA:
20.58
1oniC-2dvzA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2grk EVM001

(Ectromelia
virus) 		PF02250
(Orthopox_35kD) 		4 LEU A 221
ILE A  27
PHE A 184
ILE A 168
 None
 0.90A 1oniB-2grkA:
undetectable
1oniC-2grkA:
undetectable		 1oniB-2grkA:
21.49
1oniC-2grkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		4 LEU A 108
ILE A  94
ALA A 112
PRO A  90
 None
 0.89A 1oniB-2h8oA:
undetectable
1oniC-2h8oA:
undetectable		 1oniB-2h8oA:
19.69
1oniC-2h8oA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hmc DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
fabrum) 		PF00701
(DHDPS) 		4 LEU A 125
ILE A 124
PHE A 121
ALA A 133
 None
 0.99A 1oniB-2hmcA:
undetectable
1oniC-2hmcA:
undetectable		 1oniB-2hmcA:
16.91
1oniC-2hmcA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hoe N-ACETYLGLUCOSAMINE
KINASE

(Thermotoga
maritima) 		PF00480
(ROK) 		4 LEU A 163
ILE A 155
ILE A 349
PRO A 145
 None
None
None
GOL  A 370 (-4.4A)
 0.69A 1oniB-2hoeA:
undetectable
1oniC-2hoeA:
undetectable		 1oniB-2hoeA:
16.35
1oniC-2hoeA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o0o TNF SUPERFAMILY
LIGAND TL1A

(Homo sapiens) 		PF00229
(TNF) 		4 LEU A 226
ILE A 181
PHE A 218
ALA A 248
 None
 0.84A 1oniB-2o0oA:
undetectable
1oniC-2o0oA:
undetectable		 1oniB-2o0oA:
19.89
1oniC-2o0oA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		4 LEU A 119
ALA A  93
ILE A  60
PRO A  89
 None
 0.84A 1oniB-2p35A:
undetectable
1oniC-2p35A:
undetectable		 1oniB-2p35A:
23.00
1oniC-2p35A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4h VESTITONE REDUCTASE

(Medicago sativa) 		PF01370
(Epimerase) 		4 LEU X 241
ILE X 125
ALA X 237
ILE X 194
 None
 0.99A 1oniB-2p4hX:
undetectable
1oniC-2p4hX:
undetectable		 1oniB-2p4hX:
19.74
1oniC-2p4hX:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq6 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 239
ILE A 262
ALA A 228
ILE A 221
 None
 0.79A 1oniB-2qq6A:
undetectable
1oniC-2qq6A:
2.3		 1oniB-2qq6A:
16.75
1oniC-2qq6A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rad SUCCINOGLYCAN
BIOSYNTHESIS PROTEIN

(Bacillus cereus) 		PF05139
(Erythro_esteras) 		4 LEU A 387
ILE A 385
ALA A 390
ILE A  42
 None
 0.91A 1oniB-2radA:
0.8
1oniC-2radA:
undetectable		 1oniB-2radA:
17.74
1oniC-2radA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfo NUCLEOPORIN NIC96

(Saccharomyces
cerevisiae) 		PF04097
(Nic96) 		4 LEU A 242
ILE A 241
ALA A 245
ILE A 207
 None
 0.97A 1oniB-2rfoA:
undetectable
1oniC-2rfoA:
undetectable		 1oniB-2rfoA:
11.98
1oniC-2rfoA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v25 MAJOR CELL-BINDING
FACTOR

(Campylobacter
jejuni) 		PF00497
(SBP_bac_3) 		4 LEU A 163
ILE A 159
ALA A 170
ILE A 104
 None
 0.88A 1oniB-2v25A:
undetectable
1oniC-2v25A:
undetectable		 1oniB-2v25A:
20.08
1oniC-2v25A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A  42
ILE A  48
ALA A  40
ILE A  96
 None
 0.82A 1oniB-2vwkA:
undetectable
1oniC-2vwkA:
undetectable		 1oniB-2vwkA:
10.66
1oniC-2vwkA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Aquifex
aeolicus) 		PF00551
(Formyl_trans_N) 		4 LEU A 166
ILE A 170
ILE A 113
PRO A 110
 None
 0.99A 1oniB-2ywrA:
undetectable
1oniC-2ywrA:
undetectable		 1oniB-2ywrA:
20.47
1oniC-2ywrA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Pyrococcus
horikoshii) 		PF09488
(Osmo_MPGsynth) 		4 LEU A 100
ILE A 101
PHE A 104
ILE A  74
 None
 0.85A 1oniB-2zu8A:
undetectable
1oniC-2zu8A:
undetectable		 1oniB-2zu8A:
17.54
1oniC-2zu8A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		4 ILE A 308
ALA A 319
ILE A  37
PRO A 323
 None
 0.93A 1oniB-3ahiA:
undetectable
1oniC-3ahiA:
undetectable		 1oniB-3ahiA:
11.78
1oniC-3ahiA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		4 LEU A  83
ILE A  82
PHE A  79
ALA A  61
 None
 0.93A 1oniB-3b1fA:
undetectable
1oniC-3b1fA:
undetectable		 1oniB-3b1fA:
20.00
1oniC-3b1fA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8b CYSQ, SULFITE
SYNTHESIS PATHWAY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00459
(Inositol_P) 		4 LEU A  51
ILE A  47
ALA A   3
ILE A 113
 None
 0.98A 1oniB-3b8bA:
undetectable
1oniC-3b8bA:
undetectable		 1oniB-3b8bA:
19.86
1oniC-3b8bA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxj RAS
GTPASE-ACTIVATING
PROTEIN SYNGAP

(Rattus
norvegicus) 		PF00168
(C2)
PF00616
(RasGAP) 		4 LEU A 595
ILE A 499
ALA A 586
ILE A 615
 None
 0.93A 1oniB-3bxjA:
undetectable
1oniC-3bxjA:
undetectable		 1oniB-3bxjA:
14.08
1oniC-3bxjA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		4 LEU A  81
ILE A 301
ALA A  85
ILE A 309
 None
 0.83A 1oniB-3dbiA:
undetectable
1oniC-3dbiA:
undetectable		 1oniB-3dbiA:
18.32
1oniC-3dbiA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddd PUTATIVE
ACETYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF00583
(Acetyltransf_1) 		4 LEU A  39
PHE A  35
ALA A   6
ILE A  17
 None
 0.97A 1oniB-3dddA:
undetectable
1oniC-3dddA:
undetectable		 1oniB-3dddA:
20.14
1oniC-3dddA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 413
ILE A 265
ALA A 357
ILE A 245
 None
 0.98A 1oniB-3e60A:
1.8
1oniC-3e60A:
undetectable		 1oniB-3e60A:
17.46
1oniC-3e60A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxt NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		no annotation 4 LEU A  95
ILE A  97
PHE A 104
ALA A 108
 None
 0.99A 1oniB-3fxtA:
undetectable
1oniC-3fxtA:
undetectable		 1oniB-3fxtA:
20.86
1oniC-3fxtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g69 SORTASE C

(Streptococcus
pneumoniae) 		PF04203
(Sortase) 		4 ILE A  50
PHE A  53
ILE A 110
PRO A 123
 None
 0.93A 1oniB-3g69A:
undetectable
1oniC-3g69A:
undetectable		 1oniB-3g69A:
21.30
1oniC-3g69A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		4 ILE A  78
PHE A  51
ALA A  49
ILE A  95
 None
 0.98A 1oniB-3gnlA:
undetectable
1oniC-3gnlA:
undetectable		 1oniB-3gnlA:
20.08
1oniC-3gnlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A 289
ILE A 358
ALA A 285
PRO A 126
 None
 0.74A 1oniB-3hskA:
2.6
1oniC-3hskA:
undetectable		 1oniB-3hskA:
18.09
1oniC-3hskA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		4 LEU A 180
ALA A 119
ILE A 113
PRO A 108
 None
 0.99A 1oniB-3ihaA:
undetectable
1oniC-3ihaA:
undetectable		 1oniB-3ihaA:
14.07
1oniC-3ihaA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ile PUTATIVE
UNCHARACTERIZED
PROTEIN

(Acidianus
filamentous
virus 1) 		PF11646
(DUF3258) 		4 ILE A  92
PHE A  71
ALA A  69
ILE A 116
 None
 0.82A 1oniB-3ileA:
undetectable
1oniC-3ileA:
undetectable		 1oniB-3ileA:
21.12
1oniC-3ileA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		4 LEU A1197
ILE A1235
ALA A1233
ILE A1148
 None
 0.81A 1oniB-3kg9A:
undetectable
1oniC-3kg9A:
undetectable		 1oniB-3kg9A:
21.91
1oniC-3kg9A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ks5 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Agrobacterium
fabrum) 		PF03009
(GDPD) 		4 ILE A  76
ALA A  74
ILE A  63
PRO A  84
 None
 0.74A 1oniB-3ks5A:
undetectable
1oniC-3ks5A:
undetectable		 1oniB-3ks5A:
20.00
1oniC-3ks5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3b ES1 FAMILY PROTEIN

(Ehrlichia
chaffeensis) 		PF01965
(DJ-1_PfpI) 		4 LEU A  90
ILE A 133
ALA A 122
ILE A 115
 None
 0.84A 1oniB-3l3bA:
undetectable
1oniC-3l3bA:
undetectable		 1oniB-3l3bA:
20.63
1oniC-3l3bA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0c LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		4 LEU C 578
ILE C 564
ALA C 610
ILE C 607
 None
 0.66A 1oniB-3m0cC:
undetectable
1oniC-3m0cC:
undetectable		 1oniB-3m0cC:
9.62
1oniC-3m0cC:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 LEU A   9
ILE A  13
ALA A 180
ILE A 190
 None
 0.97A 1oniB-3my7A:
1.0
1oniC-3my7A:
undetectable		 1oniB-3my7A:
17.70
1oniC-3my7A:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0g ISOPRENE SYNTHASE

(Populus tremula
x Populus alba) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 LEU A 275
ILE A 274
PHE A 593
PRO A 592
 None
 0.98A 1oniB-3n0gA:
undetectable
1oniC-3n0gA:
undetectable		 1oniB-3n0gA:
15.84
1oniC-3n0gA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3obw PROTEIN PELOTA
HOMOLOG

(Sulfolobus
solfataricus) 		PF03463
(eRF1_1)
PF03465
(eRF1_3) 		4 LEU A  97
ILE A  75
ALA A  38
ILE A 106
 None
 0.84A 1oniB-3obwA:
undetectable
1oniC-3obwA:
undetectable		 1oniB-3obwA:
18.89
1oniC-3obwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olz GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 361
ILE A 363
ALA A 131
ILE A 199
 None
 0.83A 1oniB-3olzA:
undetectable
1oniC-3olzA:
undetectable		 1oniB-3olzA:
16.84
1oniC-3olzA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlv GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 5

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 356
ILE A 358
ALA A 129
ILE A 196
 None
 0.92A 1oniB-3qlvA:
undetectable
1oniC-3qlvA:
undetectable		 1oniB-3qlvA:
17.78
1oniC-3qlvA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qv2 5-CYTOSINE DNA
METHYLTRANSFERASE

(Entamoeba
histolytica) 		PF00145
(DNA_methylase) 		4 ILE A 159
PHE A 307
ILE A 277
PRO A 156
 None
 0.96A 1oniB-3qv2A:
undetectable
1oniC-3qv2A:
undetectable		 1oniB-3qv2A:
15.29
1oniC-3qv2A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 100
ILE A 103
ALA A  59
PRO A  54
 None
 0.91A 1oniB-3ugvA:
undetectable
1oniC-3ugvA:
undetectable		 1oniB-3ugvA:
16.24
1oniC-3ugvA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9h ACRIFLAVINE
RESISTANCE PROTEIN B

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A 449
ILE A 445
ALA A 939
ILE A 975
 None
 0.96A 1oniB-3w9hA:
undetectable
1oniC-3w9hA:
undetectable		 1oniB-3w9hA:
10.13
1oniC-3w9hA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 LEU A 246
PHE A 228
ALA A 250
ILE A 221
 None
 0.67A 1oniB-3wajA:
undetectable
1oniC-3wajA:
undetectable		 1oniB-3wajA:
11.58
1oniC-3wajA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU A 193
ILE A 197
ALA A 232
ILE A 280
 LEU  A 193 ( 0.6A)
ILE  A 197 ( 0.7A)
ALA  A 232 ( 0.0A)
ILE  A 280 ( 0.7A)
 0.95A 1oniB-3whlA:
undetectable
1oniC-3whlA:
undetectable		 1oniB-3whlA:
20.37
1oniC-3whlA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b46 CELL DIVISION
PROTEIN FTSZ

(Haloferax
volcanii) 		PF00091
(Tubulin) 		4 ILE A   6
PHE A 101
ALA A 120
ILE A 126
 None
 0.91A 1oniB-4b46A:
4.0
1oniC-4b46A:
undetectable		 1oniB-4b46A:
17.17
1oniC-4b46A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 ILE A  81
ALA A  76
ILE A 193
PRO A 103
 None
 0.96A 1oniB-4bruA:
undetectable
1oniC-4bruA:
1.3		 1oniB-4bruA:
17.65
1oniC-4bruA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3z MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Homo sapiens) 		PF00005
(ABC_tran) 		4 LEU A 661
ILE A 664
ALA A 690
ILE A 823
 None
 0.92A 1oniB-4c3zA:
undetectable
1oniC-4c3zA:
undetectable		 1oniB-4c3zA:
23.02
1oniC-4c3zA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 LEU A 332
ILE A 336
ALA A 307
ILE A 167
 None
None
GOL  A1490 ( 4.3A)
None
 0.88A 1oniB-4d4gA:
undetectable
1oniC-4d4gA:
undetectable		 1oniB-4d4gA:
13.37
1oniC-4d4gA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 LEU A 137
ILE A 136
ALA A 147
ILE A 150
 None
 0.89A 1oniB-4d4lA:
undetectable
1oniC-4d4lA:
undetectable		 1oniB-4d4lA:
16.14
1oniC-4d4lA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		4 LEU A 762
ILE A 792
ALA A 764
ILE A 805
 None
 0.99A 1oniB-4dloA:
undetectable
1oniC-4dloA:
undetectable		 1oniB-4dloA:
21.67
1oniC-4dloA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4do7 AMIDOHYDROLASE 2

(Burkholderia
multivorans) 		PF04909
(Amidohydro_2) 		4 LEU A 189
ALA A 167
ILE A 223
PRO A 170
 None
 0.97A 1oniB-4do7A:
0.8
1oniC-4do7A:
0.7		 1oniB-4do7A:
22.36
1oniC-4do7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdf MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
C 2

(Mycobacterium
tuberculosis) 		PF01967
(MoaC) 		4 LEU A  66
ILE A  55
ALA A  69
ILE A 148
 None
 0.89A 1oniB-4fdfA:
undetectable
1oniC-4fdfA:
undetectable		 1oniB-4fdfA:
25.84
1oniC-4fdfA:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gdl AUTOPHAGY PROTEIN 5
AUTOPHAGY-RELATED
PROTEIN 16-1

(Homo sapiens;
Homo sapiens) 		PF04106
(APG5)
no annotation 		4 LEU C  21
ILE C  17
ILE B 267
PRO B 245
 None
 0.91A 1oniB-4gdlC:
undetectable
1oniC-4gdlC:
undetectable		 1oniB-4gdlC:
12.32
1oniC-4gdlC:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iu4 ARGINASE

(Leishmania
mexicana) 		PF00491
(Arginase) 		4 LEU A 108
ILE A  17
ALA A 311
ILE A 304
 None
 0.98A 1oniB-4iu4A:
undetectable
1oniC-4iu4A:
undetectable		 1oniB-4iu4A:
18.48
1oniC-4iu4A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ixj FIMBRIAL PROTEIN
(PILIN)

(Clostridioides
difficile) 		no annotation 4 LEU A 131
ILE A 132
PHE A 135
PRO A 192
 None
None
None
GOL  A 305 ( 4.9A)
 0.86A 1oniB-4ixjA:
undetectable
1oniC-4ixjA:
undetectable		 1oniB-4ixjA:
18.82
1oniC-4ixjA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 115
ILE A 119
ALA A 151
ILE A 204
 None
 0.91A 1oniB-4lgmA:
undetectable
1oniC-4lgmA:
undetectable		 1oniB-4lgmA:
19.59
1oniC-4lgmA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		4 ILE X 234
ALA X 231
PRO X 235
LYS X 236
 None
 0.99A 1oniB-4li3X:
undetectable
1oniC-4li3X:
undetectable		 1oniB-4li3X:
19.75
1oniC-4li3X:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls3 NICKEL (III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-BINDIN GPROTEIN

(Helicobacter
pylori) 		PF01497
(Peripla_BP_2) 		4 LEU A 119
ILE A  54
ALA A 161
ILE A 155
 None
 0.63A 1oniB-4ls3A:
undetectable
1oniC-4ls3A:
undetectable		 1oniB-4ls3A:
19.69
1oniC-4ls3A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu2 ANTIFREEZE PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		4 LEU A 212
ILE A 186
ALA A 218
ILE A 241
 None
 0.98A 1oniB-4nu2A:
undetectable
1oniC-4nu2A:
undetectable		 1oniB-4nu2A:
20.97
1oniC-4nu2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu3 ICE-BINDING PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		4 LEU A 192
ILE A 166
ALA A 198
ILE A 221
 None
 0.93A 1oniB-4nu3A:
undetectable
1oniC-4nu3A:
undetectable		 1oniB-4nu3A:
20.00
1oniC-4nu3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r10 PROTEIN HUMPBACK-2

(Caenorhabditis
elegans) 		PF00514
(Arm) 		4 LEU A 425
ILE A 424
PHE A 421
ALA A 467
 None
 0.97A 1oniB-4r10A:
undetectable
1oniC-4r10A:
undetectable		 1oniB-4r10A:
13.62
1oniC-4r10A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7s TETRATRICOPEPTIDE
REPEAT PROTEIN

(Parabacteroides
merdae) 		PF13432
(TPR_16) 		4 LEU A 154
ILE A 153
PHE A 150
ILE A 169
 None
None
None
EDO  A 302 (-3.9A)
 0.94A 1oniB-4r7sA:
undetectable
1oniC-4r7sA:
undetectable		 1oniB-4r7sA:
18.29
1oniC-4r7sA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rdy PARATHION HYDROLASE

(Vulcanisaeta
moutnovskia) 		PF02126
(PTE) 		4 LEU A 182
ILE A 185
ALA A 139
ILE A 103
 None
None
KCX  A 138 ( 3.4A)
None
 0.93A 1oniB-4rdyA:
undetectable
1oniC-4rdyA:
undetectable		 1oniB-4rdyA:
18.04
1oniC-4rdyA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzz INTRAFLAGELLAR
TRANSPORT COMPLEX B
PROTEIN 46
CARBOXY-TERMINAL
PROTEIN
INTRAFLAGELLAR
TRANSPORTER-LIKE
PROTEIN

(Tetrahymena
thermophila;
Tetrahymena
thermophila) 		PF12317
(IFT46_B_C)
no annotation 		4 LEU A 307
ILE A 309
ALA A 303
ILE B 565
 None
 0.88A 1oniB-4uzzA:
undetectable
1oniC-4uzzA:
undetectable		 1oniB-4uzzA:
20.14
1oniC-4uzzA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9e DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Escherichia
coli) 		PF01966
(HD) 		4 LEU A 356
ILE A 359
ILE A 109
PRO A 259
 None
 0.79A 1oniB-4x9eA:
undetectable
1oniC-4x9eA:
undetectable		 1oniB-4x9eA:
16.42
1oniC-4x9eA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 840
ILE A 839
ILE A 829
PRO A 838
 None
 0.96A 1oniB-4xgtA:
undetectable
1oniC-4xgtA:
undetectable		 1oniB-4xgtA:
8.98
1oniC-4xgtA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z37 PUTATIVE MIXED
POLYKETIDE
SYNTHASE/NON-RIBOSOM
AL PEPTIDE
SYNTHETASE

(Brevibacillus
brevis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A2702
ILE A2706
PHE A2550
ILE A2628
 None
 0.91A 1oniB-4z37A:
1.7
1oniC-4z37A:
1.5		 1oniB-4z37A:
12.58
1oniC-4z37A:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 LEU A 137
ILE A 136
ALA A 147
ILE A 150
 None
 0.88A 1oniB-5ajzA:
undetectable
1oniC-5ajzA:
undetectable		 1oniB-5ajzA:
13.85
1oniC-5ajzA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5h ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		4 LEU A 160
ILE A 134
ALA A 166
ILE A 189
 None
 0.97A 1oniB-5b5hA:
undetectable
1oniC-5b5hA:
undetectable		 1oniB-5b5hA:
23.70
1oniC-5b5hA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e02 FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 LEU A 840
ILE A 839
ILE A 829
PRO A 838
 None
 0.95A 1oniB-5e02A:
undetectable
1oniC-5e02A:
undetectable		 1oniB-5e02A:
8.92
1oniC-5e02A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ec0 ALP7A

(Bacillus
subtilis) 		no annotation 4 ILE A  33
PHE A  69
ALA A  75
ILE A  96
 None
 0.96A 1oniB-5ec0A:
undetectable
1oniC-5ec0A:
undetectable		 1oniB-5ec0A:
17.46
1oniC-5ec0A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4e SPERM-EGG FUSION
PROTEIN JUNO

(Homo sapiens) 		PF03024
(Folate_rec) 		4 LEU B 207
ALA B 223
ILE B  26
PRO B 105
 None
 0.99A 1oniB-5f4eB:
undetectable
1oniC-5f4eB:
undetectable		 1oniB-5f4eB:
19.38
1oniC-5f4eB:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ZETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 ILE z 506
ALA z 417
ILE z 138
PRO z 501
 None
 0.92A 1oniB-5gw5z:
undetectable
1oniC-5gw5z:
undetectable		 1oniB-5gw5z:
13.42
1oniC-5gw5z:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9q ENHANCER OF
POLYCOMB-LIKE
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 LEU G 192
ILE G 275
PHE G 271
ILE G 183
 None
 0.87A 1oniB-5j9qG:
undetectable
1oniC-5j9qG:
undetectable		 1oniB-5j9qG:
18.56
1oniC-5j9qG:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jnf LINEAR GRAMICIDIN
SYNTHASE SUBUNIT A

(Brevibacillus
parabrevis) 		no annotation 4 LEU C 336
ALA C 276
ILE C 321
LYS C 248
 None
 0.99A 1oniB-5jnfC:
undetectable
1oniC-5jnfC:
undetectable		 1oniB-5jnfC:
14.43
1oniC-5jnfC:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3w CPUTA1

(Curtobacterium
pusillum) 		PF01063
(Aminotran_4) 		4 ILE A 230
ALA A 205
ILE A 214
PRO A 224
 None
 0.91A 1oniB-5k3wA:
undetectable
1oniC-5k3wA:
undetectable		 1oniB-5k3wA:
19.00
1oniC-5k3wA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kkp PSEUDOURIDYLATE
SYNTHASE 7

(Homo sapiens) 		PF01142
(TruD) 		4 LEU A 448
ILE A 467
ALA A 463
ILE A 565
 None
 0.97A 1oniB-5kkpA:
undetectable
1oniC-5kkpA:
undetectable		 1oniB-5kkpA:
13.70
1oniC-5kkpA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 LEU A 367
ILE A 363
ALA A 438
ILE A 548
 None
 0.85A 1oniB-5lewA:
undetectable
1oniC-5lewA:
undetectable		 1oniB-5lewA:
9.07
1oniC-5lewA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpa 26S PROTEASE
REGULATORY SUBUNIT
6A

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU M 193
ILE M 197
ALA M 232
ILE M 280
 None
 0.79A 1oniB-5mpaM:
undetectable
1oniC-5mpaM:
undetectable		 1oniB-5mpaM:
17.01
1oniC-5mpaM:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngw OPGH99A

(Ochrovirga
pacifica) 		no annotation 4 LEU A 185
ILE A 127
ALA A 187
PRO A 132
 None
 0.94A 1oniB-5ngwA:
undetectable
1oniC-5ngwA:
undetectable		 1oniB-5ngwA:
undetectable
1oniC-5ngwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6y CHORISMATE MUTASE

(Physcomitrella
patens) 		no annotation 4 LEU A 249
ILE A 245
ALA A 222
ILE A 170
 None
 0.86A 1oniB-5w6yA:
undetectable
1oniC-5w6yA:
undetectable		 1oniB-5w6yA:
20.90
1oniC-5w6yA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		4 LEU A 287
ILE A 290
ALA A 352
ILE A 391
 None
 0.96A 1oniB-5x62A:
undetectable
1oniC-5x62A:
undetectable		 1oniB-5x62A:
16.26
1oniC-5x62A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 ILE A1990
ALA A2079
ILE A2057
LYS A2086
 None
 1.00A 1oniB-6b3rA:
undetectable
1oniC-6b3rA:
undetectable		 1oniB-6b3rA:
undetectable
1oniC-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6btm ALTERNATIVE COMPLEX
III SUBUNIT A
ALTERNATIVE COMPLEX
III SUBUNIT B

(Flavobacterium
johnsoniae;
Flavobacterium
johnsoniae) 		no annotation
no annotation 		4 LEU A 325
ILE A 258
ALA A 328
ILE B  78
 None
 0.77A 1oniB-6btmA:
undetectable
1oniC-6btmA:
undetectable		 1oniB-6btmA:
undetectable
1oniC-6btmA:
undetectable