SIMILAR PATTERNS OF AMINO ACIDS FOR 1ONI_A_BEZA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		4 PHE A  69
ALA A  38
ILE A  45
GLU A  40
 None
 0.93A 1oniA-1a5cA:
undetectable
1oniB-1a5cA:
undetectable		 1oniA-1a5cA:
16.90
1oniB-1a5cA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aoc COAGULOGEN

(Tachypleus
tridentatus) 		PF02035
(Coagulin) 		4 PHE A  51
ALA A 116
ILE A  30
GLU A  31
 None
 0.92A 1oniA-1aocA:
undetectable
1oniB-1aocA:
undetectable		 1oniA-1aocA:
19.78
1oniB-1aocA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqp GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Giardia
intestinalis) 		PF00156
(Pribosyltran) 		4 PHE A 150
ALA A  36
ILE A 219
GLU A  40
 None
 1.15A 1oniA-1dqpA:
undetectable
1oniB-1dqpA:
undetectable		 1oniA-1dqpA:
18.47
1oniB-1dqpA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 PHE A 450
ALA A 396
ILE A 391
PRO A 500
 None
 0.90A 1oniA-1fuiA:
undetectable
1oniB-1fuiA:
undetectable		 1oniA-1fuiA:
13.54
1oniB-1fuiA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 PHE A 514
ALA A 476
ILE A 388
PRO A 506
 None
 1.13A 1oniA-1fuiA:
undetectable
1oniB-1fuiA:
undetectable		 1oniA-1fuiA:
13.54
1oniB-1fuiA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 ARG A 131
TYR A 135
ILE A 115
PRO A 128
 ADP  A1100 ( 4.0A)
None
None
ADP  A1100 ( 4.6A)
 1.12A 1oniA-1g8xA:
undetectable
1oniB-1g8xA:
undetectable		 1oniA-1g8xA:
8.62
1oniB-1g8xA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hwn EBULIN

(Sambucus ebulus) 		PF00161
(RIP) 		4 PHE A 184
TYR A 169
PRO A 186
GLU A 194
 None
 1.14A 1oniA-1hwnA:
undetectable
1oniB-1hwnA:
undetectable		 1oniA-1hwnA:
15.69
1oniB-1hwnA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyx ENOLASE

(Enterococcus
hirae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 177
TYR A 403
ILE A 166
PRO A 168
 None
 1.09A 1oniA-1iyxA:
undetectable
1oniB-1iyxA:
undetectable		 1oniA-1iyxA:
15.70
1oniB-1iyxA:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1j7h HYPOTHETICAL PROTEIN
HI0719

(Haemophilus
influenzae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 116
GLU A 122
 None
 0.58A 1oniA-1j7hA:
19.0
1oniB-1j7hA:
18.7		 1oniA-1j7hA:
42.96
1oniB-1j7hA:
42.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jd1 HYPOTHETICAL 13.9
KDA PROTEIN IN
FCY2-PET117
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 114
GLU A 120
 None
 0.40A 1oniA-1jd1A:
22.4
1oniB-1jd1A:
23.1		 1oniA-1jd1A:
38.64
1oniB-1jd1A:
38.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m22 PEPTIDE AMIDASE

(Stenotrophomonas
maltophilia) 		PF01425
(Amidase) 		4 PHE A 529
ARG A  74
ALA A 212
PRO A 527
 None
 1.11A 1oniA-1m22A:
undetectable
1oniB-1m22A:
undetectable		 1oniA-1m22A:
16.85
1oniB-1m22A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odo PUTATIVE CYTOCHROME
P450 154A1

(Streptomyces
coelicolor) 		PF00067
(p450) 		4 ARG A 141
ALA A 145
ILE A 150
PRO A 149
 None
 1.12A 1oniA-1odoA:
undetectable
1oniB-1odoA:
undetectable		 1oniA-1odoA:
19.55
1oniB-1odoA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oni 14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN

(Homo sapiens) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  21
ILE A  37
PRO A 116
GLU A 122
 None
 0.41A 1oniA-1oniA:
29.1
1oniB-1oniA:
26.7		 1oniA-1oniA:
100.00
1oniB-1oniA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qah PERCHLORIC ACID
SOLUBLE PROTEIN

(Rattus
norvegicus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  20
ILE A  36
PRO A 115
GLU A 121
 None
 0.22A 1oniA-1qahA:
25.7
1oniB-1qahA:
26.5		 1oniA-1qahA:
87.50
1oniB-1qahA:
87.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE

(Sus scrofa) 		PF02971
(FTCD)
PF07837
(FTCD_N) 		4 PHE A 241
ILE A 322
PRO A 274
GLU A 323
 None
 1.06A 1oniA-1qd1A:
2.5
1oniB-1qd1A:
2.3		 1oniA-1qd1A:
19.94
1oniB-1qd1A:
19.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qd9 PURINE REGULATORY
PROTEIN YABJ

(Bacillus
subtilis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 111
GLU A 117
 None
 0.52A 1oniA-1qd9A:
23.3
1oniB-1qd9A:
23.3		 1oniA-1qd9A:
42.22
1oniB-1qd9A:
42.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qu9 YJGF PROTEIN

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.45A 1oniA-1qu9A:
22.1
1oniB-1qu9A:
21.9		 1oniA-1qu9A:
44.78
1oniB-1qu9A:
44.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjk MOLYBDOPTERIN
CONVERTING FACTOR,
SUBUNIT 1

(Pyrococcus
furiosus) 		PF02597
(ThiS) 		4 PHE A  45
ALA A  16
ILE A  23
GLU A  21
 None
 1.01A 1oniA-1vjkA:
undetectable
1oniB-1vjkA:
undetectable		 1oniA-1vjkA:
21.09
1oniB-1vjkA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w27 PHENYLALANINE
AMMONIA-LYASE 1

(Petroselinum
crispum) 		PF00221
(Lyase_aromatic) 		4 ARG A 376
ILE A 405
PRO A 404
GLU A 377
 None
 1.12A 1oniA-1w27A:
undetectable
1oniB-1w27A:
undetectable		 1oniA-1w27A:
12.30
1oniB-1w27A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcd MAJOR STRUCTURAL
PROTEIN VP2

(Infectious
bursal disease
virus) 		PF01766
(Birna_VP2) 		4 PHE J  82
ALA J  70
ILE J 237
PRO J 304
 None
 1.11A 1oniA-1wcdJ:
undetectable
1oniB-1wcdJ:
undetectable		 1oniA-1wcdJ:
18.18
1oniB-1wcdJ:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x25 HYPOTHETICAL UPF0076
PROTEIN ST0811

(Sulfurisphaera
tokodaii) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  16
ILE A  32
PRO A 111
GLU A 117
 None
 0.47A 1oniA-1x25A:
24.1
1oniB-1x25A:
24.1		 1oniA-1x25A:
43.61
1oniB-1x25A:
43.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xc6 BETA-GALACTOSIDASE

(Penicillium sp.) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 PHE A 233
ARG A 225
ALA A 224
ILE A 181
 None
 1.01A 1oniA-1xc6A:
undetectable
1oniB-1xc6A:
undetectable		 1oniA-1xc6A:
10.56
1oniB-1xc6A:
10.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY

(Ruminiclostridium
thermocellum) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 113
GLU A 119
 UNX  A 509 (-3.7A)
None
None
None
 0.51A 1oniA-1xrgA:
24.0
1oniB-1xrgA:
23.9		 1oniA-1xrgA:
44.52
1oniB-1xrgA:
44.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abj BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE,
CYTOSOLIC

(Homo sapiens) 		PF01063
(Aminotran_4) 		4 PHE A 197
ALA A 360
PRO A 357
GLU A 325
 None
 1.05A 1oniA-2abjA:
undetectable
1oniB-2abjA:
undetectable		 1oniA-2abjA:
20.86
1oniB-2abjA:
20.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2b33 PROTEIN SYNTHESIS
INHIBITOR, PUTATIVE

(Thermotoga
maritima) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 112
GLU A 118
 None
 0.43A 1oniA-2b33A:
23.4
1oniB-2b33A:
23.1		 1oniA-2b33A:
42.14
1oniB-2b33A:
42.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cwj PUTATIVE
ENDONUCLEASE

(Aeropyrum
pernix) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  11
ILE A  27
PRO A 106
GLU A 112
 None
 0.80A 1oniA-2cwjA:
18.8
1oniB-2cwjA:
19.3		 1oniA-2cwjA:
39.86
1oniB-2cwjA:
39.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejc PANTOATE--BETA-ALANI
NE LIGASE

(Thermotoga
maritima) 		PF02569
(Pantoate_ligase) 		4 PHE A 136
ALA A 144
ILE A  24
PRO A 141
 None
 0.91A 1oniA-2ejcA:
undetectable
1oniB-2ejcA:
undetectable		 1oniA-2ejcA:
21.69
1oniB-2ejcA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 4 PHE H 491
ARG H 515
ALA H 514
PRO H 484
 None
 1.12A 1oniA-2fhgH:
undetectable
1oniB-2fhgH:
undetectable		 1oniA-2fhgH:
23.01
1oniB-2fhgH:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fym ENOLASE

(Escherichia
coli) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 181
TYR A 405
ILE A 170
PRO A 172
 None
 1.09A 1oniA-2fymA:
undetectable
1oniB-2fymA:
undetectable		 1oniA-2fymA:
17.80
1oniB-2fymA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g17 N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Salmonella
enterica) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ARG A 213
ILE A 218
PRO A 156
GLU A 217
 SO4  A 410 (-3.0A)
None
None
None
 0.99A 1oniA-2g17A:
undetectable
1oniB-2g17A:
undetectable		 1oniA-2g17A:
19.53
1oniB-2g17A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hcu 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Streptococcus
mutans) 		PF00694
(Aconitase_C) 		4 PHE A  29
TYR A  48
PRO A  26
GLU A  45
 None
 1.15A 1oniA-2hcuA:
undetectable
1oniB-2hcuA:
undetectable		 1oniA-2hcuA:
20.85
1oniB-2hcuA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi1 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 2

(Salmonella
enterica) 		PF04166
(PdxA) 		4 PHE A 252
ALA A 208
TYR A 267
PRO A 248
 None
 1.04A 1oniA-2hi1A:
undetectable
1oniB-2hi1A:
2.7		 1oniA-2hi1A:
18.77
1oniB-2hi1A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j66 BTRK

(Bacillus
circulans) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 PHE A 145
ILE A 139
PRO A 141
GLU A 163
 None
 1.03A 1oniA-2j66A:
undetectable
1oniB-2j66A:
undetectable		 1oniA-2j66A:
16.46
1oniB-2j66A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		4 PHE A 672
ALA A 571
ILE A 442
GLU A 268
 None
 1.06A 1oniA-2odpA:
undetectable
1oniB-2odpA:
undetectable		 1oniA-2odpA:
14.54
1oniB-2odpA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa6 ENOLASE

(Methanocaldococcus
jannaschii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 184
TYR A 403
ILE A 173
PRO A 175
 None
 1.05A 1oniA-2pa6A:
undetectable
1oniB-2pa6A:
undetectable		 1oniA-2pa6A:
17.28
1oniB-2pa6A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qag SEPTIN-2
SEPTIN-6

(Homo sapiens;
Homo sapiens) 		PF00735
(Septin)
PF00735
(Septin) 		4 PHE A 156
ALA B 188
ILE B 183
PRO B 157
 None
 0.80A 1oniA-2qagA:
undetectable
1oniB-2qagA:
undetectable		 1oniA-2qagA:
16.06
1oniB-2qagA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp2 UNKNOWN PROTEIN

(Photorhabdus
laumondii) 		PF01823
(MACPF) 		4 ARG A  28
ALA A  41
ILE A  70
PRO A  90
 None
 1.01A 1oniA-2qp2A:
undetectable
1oniB-2qp2A:
undetectable		 1oniA-2qp2A:
21.99
1oniB-2qp2A:
21.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2uyk PROTEIN TDCF

(Escherichia
coli) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 114
GLU A 120
 None
 0.26A 1oniA-2uykA:
22.0
1oniB-2uykA:
22.3		 1oniA-2uykA:
39.01
1oniB-2uykA:
39.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 PHE B 733
ARG B 269
ILE B 698
GLU B 678
 None
 1.08A 1oniA-2w55B:
undetectable
1oniB-2w55B:
undetectable		 1oniA-2w55B:
11.34
1oniB-2w55B:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 PHE A 518
ALA A 480
ILE A 393
PRO A 510
 None
 1.07A 1oniA-3a9sA:
undetectable
1oniB-3a9sA:
undetectable		 1oniA-3a9sA:
14.36
1oniB-3a9sA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ag6 PANTOTHENATE
SYNTHETASE

(Staphylococcus
aureus) 		PF02569
(Pantoate_ligase) 		4 PHE A 137
ALA A 145
ILE A  25
PRO A 142
 None
 1.01A 1oniA-3ag6A:
undetectable
1oniB-3ag6A:
undetectable		 1oniA-3ag6A:
22.91
1oniB-3ag6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8o LIPOPOLYSACCHARIDE
BIOSYNTHESIS PROTEIN
WZZE

(Escherichia
coli) 		no annotation 4 PHE A 154
ARG A  64
TYR A 102
ILE A  61
 None
 0.86A 1oniA-3b8oA:
undetectable
1oniB-3b8oA:
undetectable		 1oniA-3b8oA:
20.46
1oniB-3b8oA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220

(Histophilus
somni) 		PF05114
(DUF692) 		4 PHE A  91
ILE A  37
PRO A  33
GLU A  34
 None
 1.07A 1oniA-3bwwA:
undetectable
1oniB-3bwwA:
undetectable		 1oniA-3bwwA:
20.07
1oniB-3bwwA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE

(Escherichia
coli) 		PF00425
(Chorismate_bind) 		4 PHE A 363
ALA A 196
TYR A 368
ILE A 417
 None
 1.06A 1oniA-3bzmA:
undetectable
1oniB-3bzmA:
undetectable		 1oniA-3bzmA:
15.94
1oniB-3bzmA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmy HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MQSA
(YGIT/B3021)

(Escherichia
coli) 		PF15731
(MqsA_antitoxin) 		4 ARG A 101
ALA A 107
ILE A  74
PRO A 109
 None
MEQ  A 108 ( 3.1A)
None
MEQ  A 108 ( 2.6A)
 0.93A 1oniA-3fmyA:
undetectable
1oniB-3fmyA:
undetectable		 1oniA-3fmyA:
20.14
1oniB-3fmyA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnl UNCHARACTERIZED
PROTEIN, DUF633,
LMOF2365_1472

(Listeria
monocytogenes) 		PF04816
(TrmK) 		4 ARG A 137
ALA A 133
ILE A 108
PRO A 129
 None
 1.14A 1oniA-3gnlA:
undetectable
1oniB-3gnlA:
undetectable		 1oniA-3gnlA:
20.08
1oniB-3gnlA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs6 BETA-HEXOSAMINIDASE

(Vibrio cholerae) 		PF00933
(Glyco_hydro_3) 		4 ALA A 218
TYR A 223
ILE A 184
PRO A 163
 None
 0.89A 1oniA-3gs6A:
undetectable
1oniB-3gs6A:
undetectable		 1oniA-3gs6A:
18.24
1oniB-3gs6A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ifs GLUCOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
anthracis) 		PF00342
(PGI) 		4 TYR A  55
ILE A  63
PRO A 214
GLU A  59
 None
 1.15A 1oniA-3ifsA:
undetectable
1oniB-3ifsA:
undetectable		 1oniA-3ifsA:
15.96
1oniB-3ifsA:
15.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k0t ENDORIBONUCLEASE
L-PSP, PUTATIVE

(Pseudomonas
syringae group
genomosp. 3) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  18
ILE A  34
PRO A 112
GLU A 118
 BGC  A 127 (-3.1A)
BGC  A 127 (-4.0A)
None
BGC  A 127 (-3.5A)
 0.61A 1oniA-3k0tA:
23.1
1oniB-3k0tA:
23.1		 1oniA-3k0tA:
40.94
1oniB-3k0tA:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 PHE A  61
ALA A  30
ILE A  37
GLU A  32
 None
 0.83A 1oniA-3kx6A:
undetectable
1oniB-3kx6A:
undetectable		 1oniA-3kx6A:
20.11
1oniB-3kx6A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l22 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 412
ALA A 351
ILE A 262
GLU A 271
 None
 1.15A 1oniA-3l22A:
undetectable
1oniB-3l22A:
undetectable		 1oniA-3l22A:
18.80
1oniB-3l22A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 PHE A  53
ALA A  22
ILE A  29
GLU A  24
 None
None
None
2FP  A 350 ( 4.9A)
 0.93A 1oniA-3mmtA:
undetectable
1oniB-3mmtA:
undetectable		 1oniA-3mmtA:
19.88
1oniB-3mmtA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnf PAC2 FAMILY PROTEIN

(Streptomyces
avermitilis) 		PF09754
(PAC2) 		4 PHE A  56
ALA A  50
ILE A  98
PRO A  75
 None
 1.04A 1oniA-3mnfA:
undetectable
1oniB-3mnfA:
undetectable		 1oniA-3mnfA:
21.63
1oniB-3mnfA:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mqw PUTATIVE
ENDORIBONUCLEASE
L-PSP

(Entamoeba
histolytica) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 FLC  A 140 (-4.0A)
FLC  A 140 (-4.8A)
FLC  A 140 (-4.5A)
FLC  A 140 (-2.8A)
 0.43A 1oniA-3mqwA:
23.0
1oniB-3mqwA:
22.8		 1oniA-3mqwA:
42.75
1oniB-3mqwA:
42.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 014  A 417 (-3.1A)
014  A 417 ( 3.9A)
None
None
 1.06A 1oniA-3ouhA:
undetectable
1oniB-3ouhA:
undetectable		 1oniA-3ouhA:
20.00
1oniB-3ouhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oui EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 383
ALA A 385
TYR A 303
ILE A 256
 42Z  A 393 (-2.9A)
42Z  A 393 ( 4.3A)
None
None
 1.02A 1oniA-3ouiA:
undetectable
1oniB-3ouiA:
undetectable		 1oniA-3ouiA:
21.23
1oniB-3ouiA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		4 PHE A 891
ARG A 927
ALA A 887
ILE A 790
 None
 1.00A 1oniA-3ptyA:
undetectable
1oniB-3ptyA:
undetectable		 1oniA-3ptyA:
18.81
1oniB-3ptyA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 PHE A 471
ALA A 416
ILE A 251
GLU A 261
 None
 1.12A 1oniA-3qnkA:
undetectable
1oniB-3qnkA:
undetectable		 1oniA-3qnkA:
14.86
1oniB-3qnkA:
14.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3quw PROTEIN MMF1

(Saccharomyces
cerevisiae) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  36
ILE A  52
PRO A 130
GLU A 136
 None
 0.39A 1oniA-3quwA:
22.5
1oniB-3quwA:
22.4		 1oniA-3quwA:
32.68
1oniB-3quwA:
32.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3r0p L-PSP PUTATIVE
ENDORIBONUCLEASE

(uncultured
organism) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  19
ILE A  35
PRO A 114
GLU A 120
 None
 0.53A 1oniA-3r0pA:
23.4
1oniB-3r0pA:
23.2		 1oniA-3r0pA:
43.18
1oniB-3r0pA:
43.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 PHE B 437
ALA B 548
ILE B 553
PRO B 435
 None
 0.73A 1oniA-3u9rB:
undetectable
1oniB-3u9rB:
undetectable		 1oniA-3u9rB:
13.65
1oniB-3u9rB:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		4 PHE A  77
ALA A 146
ILE A 121
PRO A 118
 URE  A 904 (-4.6A)
None
None
None
 0.99A 1oniA-3umvA:
undetectable
1oniB-3umvA:
undetectable		 1oniA-3umvA:
16.89
1oniB-3umvA:
16.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vcz ENDORIBONUCLEASE
L-PSP

(Vibrio
vulnificus) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 115
GLU A 121
 None
 0.39A 1oniA-3vczA:
21.5
1oniB-3vczA:
21.5		 1oniA-3vczA:
37.01
1oniB-3vczA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbp NEURAL/ECTODERMAL
DEVELOPMENT FACTOR
IMP-L2

(Drosophila
melanogaster) 		PF07679
(I-set) 		4 PHE A  35
ALA A 125
ILE A  53
PRO A  39
 None
 0.93A 1oniA-4cbpA:
undetectable
1oniB-4cbpA:
undetectable		 1oniA-4cbpA:
21.14
1oniB-4cbpA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 PHE A 134
ALA A 103
ILE A 110
GLU A 105
 None
 0.74A 1oniA-4d2jA:
undetectable
1oniB-4d2jA:
undetectable		 1oniA-4d2jA:
17.75
1oniB-4d2jA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		4 ARG W 814
ILE W 471
PRO W 435
GLU W 390
 None
 1.06A 1oniA-4f5xW:
undetectable
1oniB-4f5xW:
undetectable		 1oniA-4f5xW:
8.95
1oniB-4f5xW:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkx HEMAGGLUTININ HA1

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		4 ALA E 200
TYR E 195
ILE E 217
PRO E 215
 None
 1.08A 1oniA-4hkxE:
undetectable
1oniB-4hkxE:
undetectable		 1oniA-4hkxE:
20.39
1oniB-4hkxE:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0e HEAVY METAL CATION
TRICOMPONENT EFFLUX
PUMP ZNEA(CZCA-LIKE)

(Cupriavidus
metallidurans) 		PF00873
(ACR_tran) 		4 PHE A 451
ALA A 465
TYR A 458
ILE A 382
 None
 1.11A 1oniA-4k0eA:
undetectable
1oniB-4k0eA:
undetectable		 1oniA-4k0eA:
9.30
1oniB-4k0eA:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4klz GTP-BINDING PROTEIN
RIT1

(Homo sapiens) 		PF00071
(Ras) 		4 PHE A 161
ALA A 177
PRO A 159
GLU A 181
 None
 0.96A 1oniA-4klzA:
undetectable
1oniB-4klzA:
undetectable		 1oniA-4klzA:
23.12
1oniB-4klzA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mks ENOLASE 2

(Lactobacillus
gasseri) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 ALA A 178
TYR A 403
ILE A 167
PRO A 169
 None
 1.05A 1oniA-4mksA:
undetectable
1oniB-4mksA:
undetectable		 1oniA-4mksA:
17.02
1oniB-4mksA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n30 PROTEIN DISULFIDE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF13462
(Thioredoxin_4) 		4 ARG A 107
ALA A 106
ILE A 172
PRO A  94
 None
 1.09A 1oniA-4n30A:
undetectable
1oniB-4n30A:
undetectable		 1oniA-4n30A:
17.89
1oniB-4n30A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9u NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 PHE B 109
ALA B 118
ILE B  99
GLU B 221
 None
 1.01A 1oniA-4o9uB:
undetectable
1oniB-4o9uB:
undetectable		 1oniA-4o9uB:
16.92
1oniB-4o9uB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ALA A2064
TYR A2086
ILE A1784
GLU A1798
 None
 1.06A 1oniA-4o9xA:
undetectable
1oniB-4o9xA:
undetectable		 1oniA-4o9xA:
5.07
1oniB-4o9xA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pbx RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00041
(fn3)
PF07679
(I-set) 		4 PHE A 234
ALA A 309
ILE A 251
PRO A 238
 None
 1.05A 1oniA-4pbxA:
undetectable
1oniB-4pbxA:
undetectable		 1oniA-4pbxA:
13.68
1oniB-4pbxA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qaw XYN30D

(Paenibacillus
barcinonensis) 		PF03422
(CBM_6)
PF17189
(Glyco_hydro_30C) 		4 ALA A 200
TYR A 212
ILE A 181
PRO A 172
 None
 1.02A 1oniA-4qawA:
undetectable
1oniB-4qawA:
2.2		 1oniA-4qawA:
14.77
1oniB-4qawA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rml LATROPHILIN-3

(Mus musculus) 		PF02191
(OLF) 		4 PHE A 459
TYR A 389
PRO A 204
GLU A 337
 None
 1.13A 1oniA-4rmlA:
undetectable
1oniB-4rmlA:
undetectable		 1oniA-4rmlA:
18.01
1oniB-4rmlA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN

(Haliangium
ochraceum) 		PF14497
(GST_C_3) 		4 ARG A  20
ALA A  16
ILE A  71
PRO A  56
 None
 1.14A 1oniA-4w66A:
undetectable
1oniB-4w66A:
undetectable		 1oniA-4w66A:
21.49
1oniB-4w66A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		4 PHE A 141
ALA A  69
TYR A  12
ILE A  81
 None
 1.12A 1oniA-4xydA:
undetectable
1oniB-4xydA:
undetectable		 1oniA-4xydA:
14.88
1oniB-4xydA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		PF00041
(fn3)
PF07679
(I-set)
PF13927
(Ig_3) 		4 PHE A 245
ALA A 320
ILE A 262
PRO A 249
 None
 0.98A 1oniA-4y61A:
undetectable
1oniB-4y61A:
undetectable		 1oniA-4y61A:
18.13
1oniB-4y61A:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfg RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Mus musculus) 		no annotation 4 PHE B 235
ALA B 310
ILE B 252
PRO B 239
 None
 0.89A 1oniA-4yfgB:
undetectable
1oniB-4yfgB:
undetectable		 1oniA-4yfgB:
15.14
1oniB-4yfgB:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb 60S RIBOSOMAL
PROTEIN L10

(Dictyostelium
discoideum) 		PF00252
(Ribosomal_L16) 		4 ARG F  32
ALA F  29
ILE F  65
PRO F  93
 U  N1222 ( 3.3A)
None
None
None
 0.91A 1oniA-5anbF:
undetectable
1oniB-5anbF:
undetectable		 1oniA-5anbF:
20.91
1oniB-5anbF:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp8 ENT-COPALYL
DIPHOSPHATE SYNTHASE

(Streptomyces
platensis) 		PF00432
(Prenyltrans)
PF13243
(SQHop_cyclase_C) 		4 PHE A 267
ILE A 512
PRO A 508
GLU A 455
 None
 1.10A 1oniA-5bp8A:
undetectable
1oniB-5bp8A:
undetectable		 1oniA-5bp8A:
15.37
1oniB-5bp8A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ch6 FRIGIDA

(Vitis vinifera) 		PF07899
(Frigida) 		4 PHE A 319
ALA A 349
TYR A 346
ILE A 373
 None
 1.13A 1oniA-5ch6A:
undetectable
1oniB-5ch6A:
undetectable		 1oniA-5ch6A:
19.86
1oniB-5ch6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey5 LBCATS-A

(synthetic
construct) 		PF00290
(Trp_syntA) 		4 ARG A 261
ALA A  45
ILE A 236
PRO A  21
 None
 1.10A 1oniA-5ey5A:
undetectable
1oniB-5ey5A:
undetectable		 1oniA-5ey5A:
22.75
1oniB-5ey5A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN
SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron;
Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2)
PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 PHE A 226
ALA A  31
ILE B 614
PRO A 235
 None
 0.91A 1oniA-5fq6A:
undetectable
1oniB-5fq6A:
undetectable		 1oniA-5fq6A:
14.59
1oniB-5fq6A:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h8w ATP-DEPENDENT DNA
HELICASE TA0057

(Thermoplasma
acidophilum) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 ALA A 151
ILE A  68
PRO A  84
GLU A  64
 None
 1.13A 1oniA-5h8wA:
undetectable
1oniB-5h8wA:
undetectable		 1oniA-5h8wA:
15.15
1oniB-5h8wA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn5 EPIREGULIN ANTIBODY
LY3016859 FAB HEAVY
CHAIN
PROTRANSFORMING
GROWTH FACTOR ALPHA

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF00008
(EGF) 		4 ARG C  22
ALA C  31
ILE A  57
PRO A  55
 None
 0.89A 1oniA-5kn5C:
undetectable
1oniB-5kn5C:
undetectable		 1oniA-5kn5C:
11.59
1oniB-5kn5C:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3c DIGUANYLATE CYCLASE

(Pseudomonas
aeruginosa) 		no annotation 4 PHE A1203
ARG A1177
ALA A1173
ILE A1158
 None
 1.10A 1oniA-5m3cA:
undetectable
1oniB-5m3cA:
undetectable		 1oniA-5m3cA:
undetectable
1oniB-5m3cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8n EVPB FAMILY TYPE VI
SECRETION PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 4 ALA B 346
ILE B 337
PRO B 352
GLU B 342
 None
 1.10A 1oniA-5n8nB:
undetectable
1oniB-5n8nB:
undetectable		 1oniA-5n8nB:
undetectable
1oniB-5n8nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlm INDOXYL
UDP-GLUCOSYLTRANSFER
ASE

(Persicaria
tinctoria) 		no annotation 4 PHE A 220
ALA A 452
ILE A 248
PRO A 246
 None
 0.89A 1oniA-5nlmA:
undetectable
1oniB-5nlmA:
undetectable		 1oniA-5nlmA:
undetectable
1oniB-5nlmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 ARG A 619
ALA A 614
ILE A 782
GLU A 784
 None
 1.06A 1oniA-5ue8A:
undetectable
1oniB-5ue8A:
undetectable		 1oniA-5ue8A:
9.05
1oniB-5ue8A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uni NAD(P)
TRANSHYDROGENASE
SUBUNIT BETA

(Thermus
thermophilus) 		PF02233
(PNTB) 		4 PHE B 109
ALA B 118
ILE B  99
GLU B 221
 BEN  B 310 ( 4.2A)
None
None
None
 1.12A 1oniA-5uniB:
undetectable
1oniB-5uniB:
undetectable		 1oniA-5uniB:
19.17
1oniB-5uniB:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 PHE A 350
ALA A 336
ILE A 343
PRO A 348
 None
 1.14A 1oniA-5ur2A:
undetectable
1oniB-5ur2A:
undetectable		 1oniA-5ur2A:
10.16
1oniB-5ur2A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ur2 BIFUNCTIONAL PROTEIN
PUTA

(Bdellovibrio
bacteriovorus) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		4 PHE A 844
ALA A 802
ILE A 807
PRO A 857
 None
 1.14A 1oniA-5ur2A:
undetectable
1oniB-5ur2A:
undetectable		 1oniA-5ur2A:
10.16
1oniB-5ur2A:
10.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v4d PUTATIVE
TRANSLATIONAL
INHIBITOR PROTEIN

(Yersinia pestis) 		PF01042
(Ribonuc_L-PSP) 		4 TYR A  17
ILE A  33
PRO A 113
GLU A 119
 None
 0.35A 1oniA-5v4dA:
23.6
1oniB-5v4dA:
24.1		 1oniA-5v4dA:
45.38
1oniB-5v4dA:
45.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnp RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE DELTA

(Homo sapiens) 		no annotation 4 PHE D 229
ALA D 304
ILE D 246
PRO D 233
 None
 1.14A 1oniA-5xnpD:
undetectable
1oniB-5xnpD:
undetectable		 1oniA-5xnpD:
undetectable
1oniB-5xnpD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y31 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 22

(Homo sapiens) 		no annotation 4 PHE A 414
ALA A 375
TYR A 422
ILE A 241
 None
 1.08A 1oniA-5y31A:
undetectable
1oniB-5y31A:
undetectable		 1oniA-5y31A:
undetectable
1oniB-5y31A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6at7 PHENYLALANINE
AMMONIA-LYASE

(Sorghum bicolor) 		no annotation 4 ARG A 363
ILE A 392
PRO A 391
GLU A 364
 None
 1.11A 1oniA-6at7A:
undetectable
1oniB-6at7A:
undetectable		 1oniA-6at7A:
undetectable
1oniB-6at7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ave ACID-SENSING ION
CHANNEL 1

(Gallus gallus) 		no annotation 4 PHE A 153
ALA A 112
TYR A 159
PRO A 338
 None
 1.11A 1oniA-6aveA:
undetectable
1oniB-6aveA:
undetectable		 1oniA-6aveA:
undetectable
1oniB-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e85 -

(-) 		no annotation 4 PHE A 251
ALA A 207
TYR A 266
PRO A 247
 FMT  A 402 (-4.8A)
None
None
None
 0.99A 1oniA-6e85A:
undetectable
1oniB-6e85A:
2.5		 1oniA-6e85A:
undetectable
1oniB-6e85A:
undetectable