SIMILAR PATTERNS OF AMINO ACIDS FOR 1OM5_A_H4BA760

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae) 		PF02840
(Prp18) 		4 ARG A 123
TRP A 242
PHE A 239
GLU A 241
 None
 1.47A 1om5A-1dvkA:
undetectable
1om5B-1dvkA:
undetectable		 1om5A-1dvkA:
16.82
1om5B-1dvkA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1flg PROTEIN
(QUINOPROTEIN
ETHANOL
DEHYDROGENASE)

(Pseudomonas
aeruginosa) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		4 VAL A  41
TRP A 521
PHE A 501
GLU A 519
 None
 1.28A 1om5A-1flgA:
undetectable
1om5B-1flgA:
undetectable		 1om5A-1flgA:
20.03
1om5B-1flgA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gh2 THIOREDOXIN-LIKE
PROTEIN

(Homo sapiens) 		PF00085
(Thioredoxin) 		4 MET A  47
VAL A  26
PHE A  79
GLU A 100
 None
 1.48A 1om5A-1gh2A:
undetectable
1om5B-1gh2A:
0.0		 1om5A-1gh2A:
12.22
1om5B-1gh2A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 MET C 291
VAL C 216
PHE C 360
GLU C 353
 None
 1.29A 1om5A-1h2tC:
0.0
1om5B-1h2tC:
0.0		 1om5A-1h2tC:
19.51
1om5B-1h2tC:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
 None
 1.29A 1om5A-1kh2A:
0.1
1om5B-1kh2A:
0.0		 1om5A-1kh2A:
22.65
1om5B-1kh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
 None
 1.31A 1om5A-1l5jA:
0.0
1om5B-1l5jA:
0.0		 1om5A-1l5jA:
19.23
1om5B-1l5jA:
19.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 MET A 336
ARG A 596
VAL A 677
TRP A 678
 H4B  A 760 ( 3.8A)
H4B  A 760 (-3.5A)
H4B  A 760 (-4.6A)
H4B  A 760 ( 3.6A)
 0.43A 1om5A-1lzxA:
63.3
1om5B-1lzxA:
62.3		 1om5A-1lzxA:
100.00
1om5B-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lzx NITRIC-OXIDE
SYNTHASE

(Rattus
norvegicus) 		PF02898
(NO_synthase) 		4 TRP A 306
TRP A 676
PHE A 691
GLU A 694
 None
 0.18A 1om5A-1lzxA:
63.3
1om5B-1lzxA:
62.3		 1om5A-1lzxA:
100.00
1om5B-1lzxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m9q ENDOTHELIAL
NITRIC-OXIDE
SYNTHASE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  74
TRP A 445
PHE A 460
GLU A 463
 None
MPD  A 603 (-4.6A)
MPD  A 603 (-4.2A)
None
 0.27A 1om5A-1m9qA:
59.4
1om5B-1m9qA:
59.0		 1om5A-1m9qA:
64.72
1om5B-1m9qA:
64.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 VAL D  28
TRP D  31
PHE D  35
GLU D 132
 None
 1.37A 1om5A-1mhzD:
0.0
1om5B-1mhzD:
0.0		 1om5A-1mhzD:
20.89
1om5B-1mhzD:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN

(Pseudomonas
aeruginosa) 		PF01475
(FUR) 		4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
 None
 1.13A 1om5A-1mzbA:
undetectable
1om5B-1mzbA:
undetectable		 1om5A-1mzbA:
16.63
1om5B-1mzbA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9o PHOSPHOPANTOTHENOYLC
YSTEINE SYNTHETASE

(Homo sapiens) 		PF04127
(DFP) 		4 ARG A  65
VAL A 255
PHE A 230
GLU A 233
 None
 1.48A 1om5A-1p9oA:
undetectable
1om5B-1p9oA:
undetectable		 1om5A-1p9oA:
21.72
1om5B-1p9oA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 MET A 440
VAL A 401
TRP A 435
PHE A 432
 None
 1.04A 1om5A-1pduA:
undetectable
1om5B-1pduA:
undetectable		 1om5A-1pduA:
19.29
1om5B-1pduA:
19.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qw5 NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Mus musculus) 		PF02898
(NO_synthase) 		4 TRP A  84
TRP A 455
PHE A 470
GLU A 473
 None
 0.35A 1om5A-1qw5A:
57.8
1om5B-1qw5A:
58.0		 1om5A-1qw5A:
63.90
1om5B-1qw5A:
63.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfe HYPOTHETICAL PROTEIN
RV2991

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 VAL A  20
TRP A  52
PHE A  73
GLU A  50
 None
 1.46A 1om5A-1rfeA:
undetectable
1om5B-1rfeA:
undetectable		 1om5A-1rfeA:
17.96
1om5B-1rfeA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermotoga
maritima) 		PF01048
(PNP_UDP_1) 		4 VAL A 221
TRP A 162
PHE A 265
GLU A 161
 None
 1.46A 1om5A-1vmkA:
undetectable
1om5B-1vmkA:
undetectable		 1om5A-1vmkA:
21.53
1om5B-1vmkA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 TRP A  99
TRP A  79
PHE A  97
GLU A  78
 None
 1.15A 1om5A-1w8gA:
undetectable
1om5B-1w8gA:
undetectable		 1om5A-1w8gA:
20.28
1om5B-1w8gA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf0 TAR DNA-BINDING
PROTEIN-43

(Homo sapiens) 		PF00076
(RRM_1) 		4 MET A  17
VAL A  35
PHE A  26
GLU A  21
 None
 1.18A 1om5A-1wf0A:
undetectable
1om5B-1wf0A:
undetectable		 1om5A-1wf0A:
11.64
1om5B-1wf0A:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens) 		PF00866
(Ring_hydroxyl_B) 		4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
 None
 1.26A 1om5A-1wqlB:
undetectable
1om5B-1wqlB:
undetectable		 1om5A-1wqlB:
19.79
1om5B-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4j SULFATASE MODIFYING
FACTOR 2

(Homo sapiens) 		PF03781
(FGE-sulfatase) 		4 TRP A 235
TRP A 169
TRP A 237
GLU A 236
 None
None
None
CA  A1004 (-3.6A)
 1.17A 1om5A-1y4jA:
undetectable
1om5B-1y4jA:
undetectable		 1om5A-1y4jA:
20.94
1om5B-1y4jA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
 None
 0.99A 1om5A-2b39A:
undetectable
1om5B-2b39A:
undetectable		 1om5A-2b39A:
13.53
1om5B-2b39A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggm CENTRIN-2

(Homo sapiens) 		PF13499
(EF-hand_7) 		4 MET A 145
VAL A 157
PHE A 162
GLU A 148
 None
 1.49A 1om5A-2ggmA:
undetectable
1om5B-2ggmA:
undetectable		 1om5A-2ggmA:
17.43
1om5B-2ggmA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ich PUTATIVE ATTH

(Nitrosomonas
europaea) 		PF07143
(CrtC)
PF17186
(Lipocalin_9) 		4 ARG A 174
VAL A  27
PHE A 172
GLU A 215
 None
None
None
NHE  A   1 (-2.7A)
 1.49A 1om5A-2ichA:
undetectable
1om5B-2ichA:
undetectable		 1om5A-2ichA:
20.99
1om5B-2ichA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l82 DESIGNED PROTEIN
OR32

(synthetic
construct) 		no annotation 4 VAL A 104
TRP A  72
PHE A  95
GLU A 101
 None
 1.49A 1om5A-2l82A:
undetectable
1om5B-2l82A:
undetectable		 1om5A-2l82A:
17.54
1om5B-2l82A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q17 FORMYLGLYCINE
GENERATING ENZYME

(Streptomyces
coelicolor) 		PF03781
(FGE-sulfatase) 		4 TRP A 234
TRP A 166
TRP A 236
GLU A 235
 None
 1.31A 1om5A-2q17A:
undetectable
1om5B-2q17A:
undetectable		 1om5A-2q17A:
19.45
1om5B-2q17A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vy0 ENDO-BETA-1,3-GLUCAN
ASE

(Pyrococcus
furiosus) 		PF00722
(Glyco_hydro_16) 		4 VAL A 245
TRP A 252
PHE A 254
GLU A 251
 None
None
None
MRD  A1301 (-4.3A)
 1.45A 1om5A-2vy0A:
undetectable
1om5B-2vy0A:
undetectable		 1om5A-2vy0A:
19.82
1om5B-2vy0A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
 None
 1.39A 1om5A-2w4oA:
undetectable
1om5B-2w4oA:
undetectable		 1om5A-2w4oA:
20.81
1om5B-2w4oA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 MET A 194
VAL A  87
TRP A 184
GLU A 188
 None
 1.26A 1om5A-2x4lA:
undetectable
1om5B-2x4lA:
undetectable		 1om5A-2x4lA:
21.63
1om5B-2x4lA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhy 6-PHOSPHO-BETA-GLUCO
SIDASE BGLA

(Escherichia
coli) 		PF00232
(Glyco_hydro_1) 		4 ARG A 159
VAL A 164
PHE A  98
GLU A 108
 None
 1.47A 1om5A-2xhyA:
undetectable
1om5B-2xhyA:
undetectable		 1om5A-2xhyA:
20.28
1om5B-2xhyA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ARG A 697
VAL A 717
PHE A 698
GLU A 722
 None
 1.36A 1om5A-2xvgA:
undetectable
1om5B-2xvgA:
undetectable		 1om5A-2xvgA:
19.77
1om5B-2xvgA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
 None
 1.34A 1om5A-2ywbA:
undetectable
1om5B-2ywbA:
undetectable		 1om5A-2ywbA:
21.54
1om5B-2ywbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE

(Thermus
thermophilus) 		PF13302
(Acetyltransf_3) 		4 VAL A  64
TRP A  66
PHE A   4
GLU A   6
 None
 1.39A 1om5A-2z11A:
undetectable
1om5B-2z11A:
undetectable		 1om5A-2z11A:
17.58
1om5B-2z11A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znm THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Neisseria
meningitidis) 		PF13462
(Thioredoxin_4) 		4 ARG A 161
VAL A  62
TRP A  64
GLU A 144
 None
 1.49A 1om5A-2znmA:
undetectable
1om5B-2znmA:
undetectable		 1om5A-2znmA:
17.69
1om5B-2znmA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermococcus
kodakarensis) 		PF05916
(Sld5) 		4 VAL B  10
TRP B  30
PHE B  80
GLU B  28
 None
 1.16A 1om5A-3anwB:
undetectable
1om5B-3anwB:
undetectable		 1om5A-3anwB:
16.14
1om5B-3anwB:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT

(Cupriavidus
pinatubonensis) 		no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
 None
None
None
EDO  A 404 ( 3.8A)
 1.41A 1om5A-3b7fA:
undetectable
1om5B-3b7fA:
undetectable		 1om5A-3b7fA:
20.87
1om5B-3b7fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bit FACT COMPLEX SUBUNIT
SPT16

(Saccharomyces
cerevisiae) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 ARG A 105
VAL A  35
TRP A 147
PHE A 117
 None
 1.47A 1om5A-3bitA:
undetectable
1om5B-3bitA:
undetectable		 1om5A-3bitA:
23.55
1om5B-3bitA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d2w TAR DNA-BINDING
PROTEIN 43

(Mus musculus) 		PF00076
(RRM_1) 		4 MET A 202
VAL A 220
PHE A 211
GLU A 206
 None
 1.12A 1om5A-3d2wA:
undetectable
1om5B-3d2wA:
undetectable		 1om5A-3d2wA:
12.22
1om5B-3d2wA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber) 		PF01036
(Bac_rhodopsin) 		4 VAL A  16
TRP A  70
PHE A  88
GLU A  71
 None
 1.45A 1om5A-3ddlA:
undetectable
1om5B-3ddlA:
undetectable		 1om5A-3ddlA:
20.14
1om5B-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 VAL A 483
TRP A 349
PHE A 352
GLU A 350
 None
 1.49A 1om5A-3djaA:
undetectable
1om5B-3djaA:
undetectable		 1om5A-3djaA:
21.19
1om5B-3djaA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7g NITRIC OXIDE
SYNTHASE, INDUCIBLE

(Homo sapiens) 		PF02898
(NO_synthase) 		4 TRP A  90
TRP A 461
PHE A 476
GLU A 479
 None
 0.25A 1om5A-3e7gA:
56.7
1om5B-3e7gA:
57.0		 1om5A-3e7gA:
65.57
1om5B-3e7gA:
65.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ARG A 260
TRP A 248
PHE A 243
GLU A 245
 None
 1.34A 1om5A-3f3zA:
undetectable
1om5B-3f3zA:
undetectable		 1om5A-3f3zA:
21.03
1om5B-3f3zA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3p IPAH9.8

(Shigella
flexneri) 		PF14496
(NEL) 		4 VAL A 258
TRP A 261
TRP A 274
GLU A 314
 None
 1.32A 1om5A-3l3pA:
undetectable
1om5B-3l3pA:
undetectable		 1om5A-3l3pA:
20.65
1om5B-3l3pA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
 None
 1.40A 1om5A-3ma6A:
undetectable
1om5B-3ma6A:
undetectable		 1om5A-3ma6A:
21.55
1om5B-3ma6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE

(Bacillus
anthracis) 		PF07071
(KDGP_aldolase) 		4 ARG A 104
VAL A 153
TRP A 113
GLU A 190
 None
 1.32A 1om5A-3muxA:
undetectable
1om5B-3muxA:
undetectable		 1om5A-3muxA:
19.61
1om5B-3muxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		4 ARG A 944
TRP A1001
PHE A 946
GLU A 908
 None
 1.48A 1om5A-3n3kA:
undetectable
1om5B-3n3kA:
undetectable		 1om5A-3n3kA:
19.65
1om5B-3n3kA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ner CYTOCHROME B5 TYPE B

(Homo sapiens) 		PF00173
(Cyt-b5) 		4 ARG A  68
VAL A  61
PHE A  58
GLU A  56
 None
HEM  A 201 (-4.5A)
HEM  A 201 (-4.7A)
None
 1.41A 1om5A-3nerA:
undetectable
1om5B-3nerA:
undetectable		 1om5A-3nerA:
14.93
1om5B-3nerA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
 None
 1.20A 1om5A-3owcA:
undetectable
1om5B-3owcA:
undetectable		 1om5A-3owcA:
16.31
1om5B-3owcA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		4 MET A  83
VAL A 187
PHE A 165
GLU A  80
 None
 1.49A 1om5A-3p0lA:
undetectable
1om5B-3p0lA:
undetectable		 1om5A-3p0lA:
19.62
1om5B-3p0lA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 VAL A 149
TRP A 146
PHE A 162
GLU A 187
 None
 1.30A 1om5A-3rjyA:
undetectable
1om5B-3rjyA:
undetectable		 1om5A-3rjyA:
21.27
1om5B-3rjyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		4 VAL A 184
TRP A 156
TRP A 138
GLU A 155
 None
211  A 280 ( 4.7A)
GOL  A 278 (-3.7A)
GOL  A 278 (-3.4A)
 1.15A 1om5A-3rq0A:
undetectable
1om5B-3rq0A:
undetectable		 1om5A-3rq0A:
20.78
1om5B-3rq0A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A 286
VAL A 277
TRP A 274
PHE A 269
 DMS  A 711 (-4.1A)
None
None
DMS  A 711 (-3.9A)
 1.43A 1om5A-3sxfA:
undetectable
1om5B-3sxfA:
undetectable		 1om5A-3sxfA:
20.57
1om5B-3sxfA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 VAL A 240
TRP A 239
PHE A 305
GLU A 265
 None
 1.33A 1om5A-3ti8A:
undetectable
1om5B-3ti8A:
undetectable		 1om5A-3ti8A:
22.37
1om5B-3ti8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		4 VAL C2274
TRP C2314
PHE C2329
GLU C2310
 None
 1.31A 1om5A-4bgdC:
undetectable
1om5B-4bgdC:
undetectable		 1om5A-4bgdC:
20.63
1om5B-4bgdC:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g76 PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF14859
(Colicin_M) 		4 MET A 258
VAL A 265
TRP A  62
PHE A  85
 None
 1.33A 1om5A-4g76A:
undetectable
1om5B-4g76A:
undetectable		 1om5A-4g76A:
19.91
1om5B-4g76A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j3q CATECHOL OXIDASE

(Aspergillus
oryzae) 		PF00264
(Tyrosinase) 		4 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.32A 1om5A-4j3qA:
undetectable
1om5B-4j3qA:
undetectable		 1om5A-4j3qA:
20.32
1om5B-4j3qA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		4 TRP A 359
TRP A 299
TRP A 361
GLU A 360
 None
None
None
CA  A 517 (-3.9A)
 1.20A 1om5A-4x8dA:
undetectable
1om5B-4x8dA:
undetectable		 1om5A-4x8dA:
19.80
1om5B-4x8dA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		4 VAL A 177
TRP A 149
TRP A 128
GLU A 148
 None
EDO  A 308 (-3.6A)
EDO  A 307 (-4.0A)
EDO  A 307 (-3.4A)
 1.18A 1om5A-4xdqA:
undetectable
1om5B-4xdqA:
undetectable		 1om5A-4xdqA:
21.18
1om5B-4xdqA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
 None
 1.20A 1om5A-4xj6A:
undetectable
1om5B-4xj6A:
undetectable		 1om5A-4xj6A:
21.11
1om5B-4xj6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli) 		no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
 None
 1.17A 1om5A-4xj6A:
undetectable
1om5B-4xj6A:
undetectable		 1om5A-4xj6A:
21.11
1om5B-4xj6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7

(Homo sapiens) 		PF03133
(TTL) 		4 VAL A 288
TRP A 292
PHE A 277
GLU A 279
 None
 1.40A 1om5A-4ylrA:
undetectable
1om5B-4ylrA:
undetectable		 1om5A-4ylrA:
22.86
1om5B-4ylrA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ARG A 263
VAL A 254
TRP A 251
PHE A 246
 None
 1.49A 1om5A-4ysjA:
undetectable
1om5B-4ysjA:
undetectable		 1om5A-4ysjA:
21.18
1om5B-4ysjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zva DIGUANYLATE CYCLASE
DOSC

(Escherichia
coli) 		PF11563
(Protoglobin) 		4 MET A   8
VAL A  84
TRP A  12
GLU A  11
 None
 1.31A 1om5A-4zvaA:
undetectable
1om5B-4zvaA:
undetectable		 1om5A-4zvaA:
18.86
1om5B-4zvaA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a7x HIV-1 YU2 GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		4 TRP A 393
TRP A 338
PHE A 391
GLU A 339
 None
 1.40A 1om5A-5a7xA:
undetectable
1om5B-5a7xA:
undetectable		 1om5A-5a7xA:
20.32
1om5B-5a7xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron) 		PF15979
(Glyco_hydro_115) 		4 ARG A 505
VAL A 736
TRP A 732
GLU A 731
 None
 1.36A 1om5A-5by3A:
undetectable
1om5B-5by3A:
undetectable		 1om5A-5by3A:
19.87
1om5B-5by3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2

(Eremothecium
gossypii) 		PF10345
(Cohesin_load)
no annotation 		4 VAL B  28
TRP A 401
PHE A 397
GLU A 402
 None
 1.45A 1om5A-5c6gB:
undetectable
1om5B-5c6gB:
undetectable		 1om5A-5c6gB:
19.12
1om5B-5c6gB:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 MET A 341
VAL A 300
PHE A 350
GLU A 345
 None
 1.42A 1om5A-5ev7A:
undetectable
1om5B-5ev7A:
undetectable		 1om5A-5ev7A:
20.63
1om5B-5ev7A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjn L-AMINO ACID
DEAMINASE

(Cosenzaea
myxofaciens) 		PF01266
(DAO) 		4 ARG A 316
VAL A 438
TRP A 439
GLU A 418
 BE2  A1476 (-4.0A)
BE2  A1476 ( 4.3A)
BE2  A1476 ( 3.7A)
None
 1.32A 1om5A-5fjnA:
undetectable
1om5B-5fjnA:
undetectable		 1om5A-5fjnA:
23.52
1om5B-5fjnA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hyz GRAS FAMILY
TRANSCRIPTION FACTOR
CONTAINING PROTEIN,
EXPRESSED

(Oryza sativa) 		PF03514
(GRAS) 		4 MET A 521
VAL A 425
TRP A 577
PHE A 410
 None
 1.41A 1om5A-5hyzA:
undetectable
1om5B-5hyzA:
undetectable		 1om5A-5hyzA:
22.67
1om5B-5hyzA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jse PHIAB6 TAILSPIKE

(unidentified
phage) 		PF12708
(Pectate_lyase_3) 		4 TRP A 311
TRP A 347
PHE A 290
GLU A 313
 None
 1.45A 1om5A-5jseA:
undetectable
1om5B-5jseA:
undetectable		 1om5A-5jseA:
21.16
1om5B-5jseA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 VAL A  92
TRP A  83
PHE A  61
GLU A  84
 None
 1.29A 1om5A-5kn8A:
undetectable
1om5B-5kn8A:
undetectable		 1om5A-5kn8A:
22.08
1om5B-5kn8A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		4 VAL A 481
TRP A 736
PHE A 732
GLU A 560
 None
 1.48A 1om5A-5kqiA:
undetectable
1om5B-5kqiA:
undetectable		 1om5A-5kqiA:
20.28
1om5B-5kqiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m7r PROTEIN O-GLCNACASE

(Homo sapiens) 		PF07555
(NAGidase) 		4 ARG A  84
TRP A  73
PHE A 318
GLU A 317
 None
 1.39A 1om5A-5m7rA:
undetectable
1om5B-5m7rA:
undetectable		 1om5A-5m7rA:
18.06
1om5B-5m7rA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
 None
 1.02A 1om5A-5m8tA:
undetectable
1om5B-5m8tA:
undetectable		 1om5A-5m8tA:
20.08
1om5B-5m8tA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nyy NON-SPECIFIC
SERINE/THREONINE
PROTEIN KINASE

(Thermomonospora
curvata) 		PF03781
(FGE-sulfatase) 		4 TRP A 228
TRP A 160
TRP A 230
GLU A 229
 ACT  A 405 (-3.9A)
None
None
CA  A 407 (-3.9A)
 1.20A 1om5A-5nyyA:
undetectable
1om5B-5nyyA:
undetectable		 1om5A-5nyyA:
21.71
1om5B-5nyyA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5or4 CATECHOL OXIDASE

(Aspergillus
oryzae) 		no annotation 4 ARG A 239
TRP A  58
TRP A 143
PHE A 158
 None
 1.37A 1om5A-5or4A:
undetectable
1om5B-5or4A:
undetectable		 1om5A-5or4A:
10.39
1om5B-5or4A:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 ARG A 501
TRP A 536
TRP A 465
GLU A 507
 None
 1.38A 1om5A-5ot1A:
undetectable
1om5B-5ot1A:
undetectable		 1om5A-5ot1A:
14.43
1om5B-5ot1A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta9 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF04616
(Glyco_hydro_43) 		4 VAL A 150
TRP A 206
TRP A 198
GLU A 207
 None
 1.15A 1om5A-5ta9A:
undetectable
1om5B-5ta9A:
undetectable		 1om5A-5ta9A:
21.00
1om5B-5ta9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		PF03641
(Lysine_decarbox) 		4 MET A 112
ARG A 155
VAL A 104
PHE A 159
 None
 1.48A 1om5A-5wq3A:
undetectable
1om5B-5wq3A:
undetectable		 1om5A-5wq3A:
24.30
1om5B-5wq3A:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x89 ENDA-LIKE
PROTEIN,TRNA-SPLICIN
G ENDONUCLEASE

(Methanopyrus
kandleri) 		no annotation 4 MET A 249
VAL A 231
PHE A 258
GLU A 253
 None
 1.01A 1om5A-5x89A:
undetectable
1om5B-5x89A:
undetectable		 1om5A-5x89A:
12.70
1om5B-5x89A:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgp SECRETED XWNT8
INHIBITOR SIZZLED

(Xenopus laevis) 		PF01392
(Fz) 		4 VAL A 254
TRP A 224
PHE A 180
GLU A 222
 None
 0.93A 1om5A-5xgpA:
undetectable
1om5B-5xgpA:
undetectable		 1om5A-5xgpA:
19.72
1om5B-5xgpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwd VH CHAIN OF 059-152
VL CHAIN OF 059-152

(Homo sapiens) 		no annotation 4 MET H 105
VAL D  98
TRP D  91
TRP H  49
 None
 1.15A 1om5A-5xwdH:
undetectable
1om5B-5xwdH:
undetectable		 1om5A-5xwdH:
10.16
1om5B-5xwdH:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bk1 UDP-GLYCOSYLTRANSFER
ASE 79

(Oryza sativa) 		no annotation 4 ARG A 331
VAL A 317
TRP A 316
GLU A 322
 None
UDP  A 501 ( 4.8A)
None
None
 1.30A 1om5A-6bk1A:
undetectable
1om5B-6bk1A:
undetectable		 1om5A-6bk1A:
13.48
1om5B-6bk1A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dxp -

(-) 		no annotation 4 ARG A 157
VAL A 152
PHE A 170
GLU A 174
 None
 1.40A 1om5A-6dxpA:
undetectable
1om5B-6dxpA:
undetectable		 1om5A-6dxpA:
undetectable
1om5B-6dxpA:
undetectable