SIMILAR PATTERNS OF AMINO ACIDS FOR 1OLT_A_SAMA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 HIS A  58
GLY A 112
PHE A 240
PHE A 310
ILE A 329
 SAM  A 502 (-4.7A)
SAM  A 502 ( 4.1A)
SAM  A 502 ( 3.6A)
None
SAM  A 502 (-3.9A)
 1.19A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		9 TYR A  56
HIS A  58
GLY A 111
GLU A 145
PHE A 240
PHE A 310
GLN A 311
LEU A 321
ILE A 329
 SAM  A 502 (-3.5A)
SAM  A 502 (-4.7A)
SAM  A 502 (-3.6A)
SAM  A 502 ( 2.8A)
SAM  A 502 ( 3.6A)
None
SAM  A 502 (-3.0A)
None
SAM  A 502 (-3.9A)
 0.00A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0d 2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 GLY A 248
PHE A 262
GLN A 258
LEU A 265
ILE A 219
 None
 1.45A 1oltA-2d0dA:
0.5		 1oltA-2d0dA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 TYR A 662
HIS A 680
GLY A 736
PHE A 624
ILE A 661
 None
 1.44A 1oltA-2v9yA:
0.0		 1oltA-2v9yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		5 TYR A1269
GLY A1244
PHE A1288
LEU A1270
ILE A1273
 None
 1.28A 1oltA-2vxrA:
0.0		 1oltA-2vxrA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		5 GLY A 268
PHE A 367
PHE A 167
LEU A 170
ILE A 196
 None
 1.35A 1oltA-2z8eA:
0.0		 1oltA-2z8eA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm5 LACTOYLGLUTATHIONE
LYASE AND RELATED
LYASES

(Caldanaerobacter
subterraneus) 		PF13669
(Glyoxalase_4) 		6 HIS A  97
GLY A  15
GLU A  74
PHE A 126
GLN A  13
ILE A 144
 None
None
CIT  A 379 (-2.9A)
CIT  A 379 ( 4.8A)
CIT  A 379 (-2.8A)
None
 1.28A 1oltA-3gm5A:
0.0		 1oltA-3gm5A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i7j BETA-LACTAMASE
MB2281C

(Mycobacterium
bovis) 		PF00144
(Beta-lactamase) 		5 HIS A 226
GLY A 203
PHE A 119
LEU A 163
ILE A 234
 None
 1.31A 1oltA-3i7jA:
0.0		 1oltA-3i7jA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 TYR A   9
GLY A 195
GLU A 198
PHE A 203
ILE A   8
 None
 1.23A 1oltA-3uqzA:
0.0		 1oltA-3uqzA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 TYR A 267
HIS A 270
GLY A 269
LEU A 256
ILE A 286
 None
 1.40A 1oltA-4ci8A:
0.0		 1oltA-4ci8A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 GLY A 161
GLU A 191
PHE A 140
LEU A 177
ILE A 179
 None
 1.45A 1oltA-4lq1A:
undetectable		 1oltA-4lq1A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mgg MUCONATE LACTONIZING
ENZYME

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 PHE A 322
PHE A 162
GLN A 163
LEU A 190
ILE A 151
 None
None
MG  A 404 ( 4.3A)
None
None
 1.20A 1oltA-4mggA:
undetectable		 1oltA-4mggA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 TYR A 387
GLU A 383
PHE A 286
GLN A 366
ILE A 362
 None
 1.37A 1oltA-4mzdA:
undetectable		 1oltA-4mzdA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plj CAPSID PROTEIN
8G12 HEAVY CHAIN

(Orthohepevirus
A;
Mus musculus) 		PF03014
(SP2)
no annotation 		5 GLY A 591
GLU A 479
PHE H  62
GLN H  60
ILE H  46
 None
 1.36A 1oltA-4pljA:
undetectable		 1oltA-4pljA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5efx RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 2

(Homo sapiens) 		PF00169
(PH) 		5 GLY A 464
GLU A 467
PHE A 579
LEU A 503
ILE A 445
 None
 1.47A 1oltA-5efxA:
undetectable		 1oltA-5efxA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens) 		no annotation 5 TYR A  33
GLY A 251
PHE A  30
GLN A  32
ILE A  77
 None
 1.06A 1oltA-5oklA:
undetectable		 1oltA-5oklA:
undetectable