SIMILAR PATTERNS OF AMINO ACIDS FOR 1OLT_A_SAMA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm0 SHIGA TOXIN A
SUBUNIT

(Shigella
dysenteriae) 		PF00161
(RIP) 		5 THR A  36
GLY A 234
ILE A 174
PHE A 171
ALA A 166
 None
 1.34A 1oltA-1dm0A:
undetectable		 1oltA-1dm0A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu8 TREHALOSE/MALTOSE
BINDING PROTEIN

(Thermococcus
litoralis) 		PF01547
(SBP_bac_1) 		5 GLU A  47
ASP A  70
ARG A 364
ILE A 377
ALA A 402
 None
TRE  A 563 (-2.8A)
TRE  A 563 (-2.8A)
None
None
 1.33A 1oltA-1eu8A:
0.2		 1oltA-1eu8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f07 COENZYME
F420-DEPENDENT
N5,N10-METHYLENETETR
AHYDROMETHANOPTERIN
REDUCTASE

(Methanothermobacter
thermautotrophicus) 		PF00296
(Bac_luciferase) 		5 GLY A 246
ILE A 227
PHE A 273
ALA A 172
GLN A 153
 None
MPO  A 331 (-4.8A)
None
MPD  A 335 ( 4.9A)
None
 1.34A 1oltA-1f07A:
0.2		 1oltA-1f07A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 GLY A 169
ASP A 170
ILE A 172
PHE A   6
ALA A 159
 None
 1.21A 1oltA-1i7oA:
undetectable		 1oltA-1i7oA:
24.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 CYH A  69
THR A 114
ASP A 147
GLY A 170
ASP A 209
 SF4  A 500 ( 2.3A)
SAM  A 501 ( 3.5A)
SF4  A 500 (-4.2A)
SAM  A 501 (-3.3A)
SAM  A 501 (-3.7A)
 1.12A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		12 CYH A  71
THR A 114
GLU A 145
ASP A 147
GLY A 170
ARG A 184
ASP A 209
ILE A 211
PHE A 240
TYR A 242
ALA A 243
GLN A 252
 SAM  A 501 (-3.6A)
SAM  A 501 ( 3.5A)
SAM  A 502 ( 2.8A)
SF4  A 500 (-4.2A)
SAM  A 501 (-3.3A)
SAM  A 501 ( 2.9A)
SAM  A 501 (-3.7A)
SAM  A 501 (-4.3A)
SAM  A 502 ( 3.6A)
SAM  A 501 (-4.7A)
SAM  A 501 (-3.9A)
SAM  A 501 (-4.6A)
 0.17A 1oltA-1oltA:
68.1		 1oltA-1oltA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 CYH A 271
GLY A 296
ILE A 307
TYR A 395
ALA A 392
 None
 1.13A 1oltA-1ot5A:
0.7		 1oltA-1ot5A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pww LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF)
PF09156
(Anthrax-tox_M) 		5 THR A 191
GLY A 109
ASP A 106
ILE A 104
ALA A 121
 None
 1.38A 1oltA-1pwwA:
undetectable		 1oltA-1pwwA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rif DNA HELICASE UVSW

(Escherichia
virus T4) 		PF04851
(ResIII) 		5 CYH A  17
ASP A  55
ILE A  68
PHE A  71
ALA A  79
 None
None
AU  A 285 (-4.6A)
None
AU  A 285 (-3.5A)
 1.04A 1oltA-1rifA:
0.2		 1oltA-1rifA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		5 THR A 466
ASP A 353
GLY A 404
ASP A 399
ALA A 178
 None
 1.12A 1oltA-1t1eA:
0.3		 1oltA-1t1eA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tbu PEROXISOMAL
ACYL-COENZYME A
THIOESTER HYDROLASE
1

(Saccharomyces
cerevisiae) 		PF13622
(4HBT_3) 		5 THR A  78
ASP A  75
GLY A  74
ILE A  71
PHE A 108
 None
 1.35A 1oltA-1tbuA:
undetectable		 1oltA-1tbuA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkm METHIONINE
AMINOPEPTIDASE

(Pyrococcus
furiosus) 		PF00557
(Peptidase_M24) 		5 GLY A 181
ASP A 182
ILE A 283
PHE A 184
ALA A 118
 None
 1.10A 1oltA-1wkmA:
undetectable		 1oltA-1wkmA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg2 PECTINESTERASE
INHIBITOR

(Actinidia
chinensis) 		PF04043
(PMEI) 		5 CYH B 139
ASP B 132
GLY B 112
ASP B 109
GLN B  45
 None
 1.33A 1oltA-1xg2B:
undetectable		 1oltA-1xg2B:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yiq QUINOHEMOPROTEIN
ALCOHOL
DEHYDROGENASE

(Pseudomonas
putida) 		PF01011
(PQQ)
PF13360
(PQQ_2)
PF13442
(Cytochrome_CBB3) 		5 THR A 534
GLY A  90
ASP A  86
ILE A  93
ALA A 138
 None
 1.29A 1oltA-1yiqA:
undetectable		 1oltA-1yiqA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ASP A   6
GLY A  10
ASP A  13
PHE A  17
ALA A 227
 None
 1.38A 1oltA-1yzyA:
undetectable		 1oltA-1yzyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5z HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00271
(Helicase_C) 		5 CYH A 670
GLU A 862
ASP A 866
ILE A 823
PHE A 825
 None
 1.35A 1oltA-1z5zA:
undetectable		 1oltA-1z5zA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b81 LUCIFERASE-LIKE
MONOOXYGENASE

(Bacillus cereus) 		PF00296
(Bac_luciferase) 		5 THR A 197
GLY A 134
ASP A 135
PHE A  70
ALA A  74
 None
 1.24A 1oltA-2b81A:
3.9		 1oltA-2b81A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2da9 SH3-DOMAIN KINASE
BINDING PROTEIN 1

(Mus musculus) 		PF14604
(SH3_9) 		5 GLY A  29
ASP A  30
ILE A  26
TYR A  16
ALA A  18
 None
 1.29A 1oltA-2da9A:
undetectable		 1oltA-2da9A:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 THR A  26
GLY A 267
ASP A 137
ILE A 139
TYR A  44
 None
 1.16A 1oltA-2e3dA:
undetectable		 1oltA-2e3dA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fep CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF13377
(Peripla_BP_3) 		5 THR A 278
ASP A 276
GLY A 274
ILE A 255
ALA A 258
 SO4  A4396 (-2.9A)
SO4  A4396 (-3.5A)
None
None
None
 1.35A 1oltA-2fepA:
undetectable		 1oltA-2fepA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ASP A 550
GLY A 506
ARG A 513
ILE A 514
ALA A 232
 None
None
None
None
SRM  A 580 (-4.2A)
 1.15A 1oltA-2gepA:
undetectable		 1oltA-2gepA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k9g SH3
DOMAIN-CONTAINING
KINASE-BINDING
PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		5 GLY A 291
ASP A 292
ILE A 288
TYR A 278
ALA A 280
 None
 1.33A 1oltA-2k9gA:
undetectable		 1oltA-2k9gA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kyf PARVALBUMIN, THYMIC
CPV3

(Gallus gallus) 		PF13499
(EF-hand_7) 		5 GLY A  93
ASP A  94
ILE A  97
ALA A  99
GLN A 103
 None
CA  A 110 (-3.4A)
None
None
None
 1.19A 1oltA-2kyfA:
undetectable		 1oltA-2kyfA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q27 OXALYL-COA
DECARBOXYLASE

(Escherichia
coli) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 CYH A 461
ASP A 507
GLY A 513
ILE A 469
ALA A 430
 None
 1.29A 1oltA-2q27A:
undetectable		 1oltA-2q27A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qhp FRUCTOKINASE

(Bacteroides
thetaiotaomicron) 		PF00294
(PfkB) 		5 THR A 241
ASP A 240
GLY A 281
ILE A  22
ALA A  11
 None
 1.22A 1oltA-2qhpA:
3.7		 1oltA-2qhpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		5 THR A  41
GLU A 304
GLY A 299
ILE A 294
ALA A 343
 None
 1.18A 1oltA-2rjoA:
undetectable		 1oltA-2rjoA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		5 ASP A 552
ARG A 885
ASP A 837
ILE A 886
ALA A 807
 None
 1.28A 1oltA-2x05A:
undetectable		 1oltA-2x05A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2c 1,6-ANHYDRO-N-ACETYL
MURAMYL-L-ALANINE
AMIDASE AMPD

(Citrobacter
freundii) 		PF01510
(Amidase_2) 		5 GLY A 119
ARG A  80
ILE A  78
ALA A 134
GLN A 131
 None
 1.07A 1oltA-2y2cA:
undetectable		 1oltA-2y2cA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT BETA

(Mus musculus) 		PF00017
(SH2)
PF16454
(PI3K_P85_iSH2) 		5 THR B 703
ASP B 656
GLY B 657
ASP B 658
ALA B 626
 None
 1.10A 1oltA-2y3aB:
undetectable		 1oltA-2y3aB:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ydl SH3
DOMAIN-CONTAINING
KINASE-BINDING
PROTEIN 1

(Homo sapiens) 		PF14604
(SH3_9) 		5 GLY A 291
ASP A 292
ILE A 288
TYR A 278
ALA A 280
 None
 1.33A 1oltA-2ydlA:
undetectable		 1oltA-2ydlA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 ASP A 191
GLY A 233
ARG A 250
ILE A 236
ALA A 198
 None
 1.28A 1oltA-2ymuA:
undetectable		 1oltA-2ymuA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 ASP A 478
GLY A 520
ARG A 537
ILE A 523
ALA A 485
 None
 1.19A 1oltA-2ymuA:
undetectable		 1oltA-2ymuA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ymu WD-40 REPEAT PROTEIN

(Nostoc
punctiforme) 		PF00400
(WD40) 		5 ASP A 560
GLY A 315
ARG A 332
ILE A 318
ALA A 567
 None
 1.12A 1oltA-2ymuA:
undetectable		 1oltA-2ymuA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		5 ASP A  74
GLY A  77
ILE A  66
PHE A  82
ALA A  34
 ZN  A 319 (-2.8A)
None
None
None
None
 1.31A 1oltA-2zo4A:
undetectable		 1oltA-2zo4A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6q SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Thermotoga
maritima) 		no annotation 5 THR B 111
GLY B 235
ASP B 216
ILE B 221
ALA B 198
 None
 1.37A 1oltA-3c6qB:
undetectable		 1oltA-3c6qB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cty THIOREDOXIN
REDUCTASE

(Thermoplasma
acidophilum) 		PF07992
(Pyr_redox_2) 		5 THR A 108
ASP A 110
GLY A  91
ILE A  88
ALA A  32
 None
 1.20A 1oltA-3ctyA:
undetectable		 1oltA-3ctyA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 CYH A 200
ASP A 129
GLY A 131
TYR A 193
GLN A 232
 None
 1.37A 1oltA-3djcA:
undetectable		 1oltA-3djcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dqq PUTATIVE TRNA
SYNTHASE

(Salmonella
enterica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 ASP A   9
GLY A  13
ASP A  16
PHE A  20
ALA A 230
 None
 1.30A 1oltA-3dqqA:
undetectable		 1oltA-3dqqA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 THR A1392
GLY A1290
ASP A1407
TYR A1320
ALA A1364
 None
 1.39A 1oltA-3ecqA:
undetectable		 1oltA-3ecqA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esh PROTEIN SIMILAR TO
METAL-DEPENDENT
HYDROLASE

(Staphylococcus
aureus) 		PF00753
(Lactamase_B) 		5 THR A  16
ASP A 112
GLY A  65
ILE A  51
ALA A 257
 None
 1.38A 1oltA-3eshA:
undetectable		 1oltA-3eshA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 GLU B  72
GLY B 117
ASP B 388
ILE B 389
GLN B 368
 None
 1.00A 1oltA-3hkzB:
undetectable		 1oltA-3hkzB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 249
GLY A 300
ASP A 301
ILE A 274
ALA A 109
 MG  A 386 (-3.1A)
None
None
None
None
 1.36A 1oltA-3i6eA:
3.4		 1oltA-3i6eA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 247
GLY A 296
ASP A 297
ILE A 270
ALA A 107
 MG  A 381 (-3.1A)
None
None
None
None
 1.36A 1oltA-3i6tA:
3.7		 1oltA-3i6tA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 9

(Thermus
thermophilus) 		PF12838
(Fer4_7) 		5 CYH 9  98
ASP 9 118
GLY 9 116
ILE 9 113
ALA 9  60
 SF4  9 183 (-2.2A)
None
None
SF4  9 184 (-4.0A)
None
 1.19A 1oltA-3i9v9:
undetectable		 1oltA-3i9v9:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqd OCTOPINE
DEHYDROGENASE

(Pecten maximus) 		PF02317
(Octopine_DH) 		5 CYH B 382
THR B 379
ASP B 376
GLY B 374
ALA B 341
 None
 1.24A 1oltA-3iqdB:
undetectable		 1oltA-3iqdB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyn QUINONE
OXIDOREDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A  89
GLU A  64
GLY A  62
ASP A  44
ALA A 241
 None
None
None
None
NDP  A 350 (-3.7A)
 1.29A 1oltA-3jynA:
undetectable		 1oltA-3jynA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksc LEGA CLASS

(Pisum sativum) 		PF00190
(Cupin_1) 		5 THR A 401
ASP A 404
GLY A 405
TYR A 432
ALA A 434
 None
 1.18A 1oltA-3kscA:
undetectable		 1oltA-3kscA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lod PUTATIVE ACYL-COA
N-ACYLTRANSFERASE

(Klebsiella
pneumoniae) 		PF00583
(Acetyltransf_1) 		5 GLY A  63
ILE A  52
TYR A   2
ALA A   0
GLN A  87
 None
 1.13A 1oltA-3lodA:
undetectable		 1oltA-3lodA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 247
GLU A 244
ASP A 185
GLY A 156
PHE A 199
 FMT  A 721 (-4.1A)
None
None
TDP  A 701 ( 3.7A)
None
 1.21A 1oltA-3m49A:
undetectable		 1oltA-3m49A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o6x GLUTAMINE SYNTHETASE

(Bacteroides
fragilis) 		PF00120
(Gln-synt_C)
PF12437
(GSIII_N) 		5 THR A  61
GLY A 152
ASP A 151
ILE A 168
ALA A 176
 None
 1.30A 1oltA-3o6xA:
undetectable		 1oltA-3o6xA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 THR A 278
ASP A 276
GLY A 274
ILE A 255
ALA A 258
 None
 1.36A 1oltA-3oqnA:
undetectable		 1oltA-3oqnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rw7 NUCLEAR RNA EXPORT
FACTOR 1

(Homo sapiens) 		PF09162
(Tap-RNA_bind) 		5 GLY A 353
ARG A 350
ILE A 295
ALA A 226
GLN A 224
 None
 1.32A 1oltA-3rw7A:
undetectable		 1oltA-3rw7A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 GLY A1755
ARG A1730
ASP A1753
PHE A1751
ALA A1769
 None
 1.30A 1oltA-3topA:
undetectable		 1oltA-3topA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uow GMP SYNTHETASE

(Plasmodium
falciparum) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		5 GLY A 290
ASP A 288
ILE A 287
PHE A 286
ALA A 260
 None
 1.26A 1oltA-3uowA:
undetectable		 1oltA-3uowA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 THR A1953
ASP A1954
ILE A1927
PHE A1934
TYR A1936
 ADP  A9001 (-4.0A)
None
None
None
None
 1.11A 1oltA-3vkgA:
undetectable		 1oltA-3vkgA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vss BETA-FRUCTOFURANOSID
ASE

(Microbacterium
saccharophilum) 		PF02435
(Glyco_hydro_68) 		5 THR A 389
GLU A 374
ASP A 112
PHE A 470
ALA A 487
 None
FRU  A 601 (-3.1A)
FRU  A 601 (-3.1A)
None
None
 1.38A 1oltA-3vssA:
undetectable		 1oltA-3vssA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo8 BETA-N-ACETYLGLUCOSA
MINIDASE

(Thermotoga
maritima) 		PF00933
(Glyco_hydro_3) 		5 CYH A 158
THR A 208
GLY A 164
ASP A 117
ALA A 146
 None
 1.35A 1oltA-3wo8A:
undetectable		 1oltA-3wo8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE

(Arthrobacter
globiformis) 		PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3) 		5 ASP A 191
GLY A 174
ARG A 125
ASP A 173
ALA A 167
 None
 1.25A 1oltA-3x3yA:
undetectable		 1oltA-3x3yA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 GLU A 202
GLY A 197
ASP A 195
ILE A 148
ALA A 178
 None
 1.30A 1oltA-4c30A:
undetectable		 1oltA-4c30A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 248
GLU A 245
ASP A 186
GLY A 157
ALA A 198
 None
 1.31A 1oltA-4c7vA:
undetectable		 1oltA-4c7vA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 THR A 248
GLU A 245
GLY A 157
PHE A 200
ALA A 198
 None
 1.15A 1oltA-4c7vA:
undetectable		 1oltA-4c7vA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d48 GLUCOSE-1-PHOSPHATE
URIDYLYLTRANSFERASE

(Erwinia
amylovora) 		PF00483
(NTP_transferase) 		5 THR A  26
GLY A 267
ASP A 137
ILE A 139
TYR A  44
 None
 1.18A 1oltA-4d48A:
undetectable		 1oltA-4d48A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4di1 ENOYL-COA HYDRATASE
ECHA17

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 THR A  27
ASP A  64
GLY A  62
ILE A  58
PHE A  59
 None
 1.22A 1oltA-4di1A:
undetectable		 1oltA-4di1A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 THR A  33
ASP A 256
GLY A  28
ILE A 135
ALA A 110
 None
 1.27A 1oltA-4e69A:
undetectable		 1oltA-4e69A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacteroides
abscessus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 GLY A  29
ARG A 207
ILE A 196
PHE A 193
ALA A 238
 None
None
None
C5P  A 401 (-3.5A)
None
 1.37A 1oltA-4emdA:
undetectable		 1oltA-4emdA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN

(Arabidopsis
thaliana) 		PF00225
(Kinesin) 		5 ASP A1173
GLY A1176
ILE A1150
TYR A1203
ALA A1204
 None
 1.34A 1oltA-4frzA:
undetectable		 1oltA-4frzA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g38 SULFITE REDUCTASE
[NADPH] HEMOPROTEIN
BETA-COMPONENT

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 ASP A 550
GLY A 506
ARG A 513
ILE A 514
ALA A 232
 None
None
None
None
SRM  A 604 ( 4.2A)
 1.04A 1oltA-4g38A:
undetectable		 1oltA-4g38A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gsn GLUTATHIONE
S-TRANSFERASE E2

(Anopheles
gambiae) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 THR A 144
ASP A 159
ILE A 157
TYR A  86
GLN A  93
 None
 1.17A 1oltA-4gsnA:
undetectable		 1oltA-4gsnA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hl7 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Vibrio cholerae) 		PF04095
(NAPRTase) 		5 GLU A 393
GLY A 296
ILE A 273
ALA A 275
GLN A 248
 None
 1.27A 1oltA-4hl7A:
undetectable		 1oltA-4hl7A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 GLU A 804
ARG A 612
PHE A 639
TYR A 621
ALA A 619
 None
 1.16A 1oltA-4il1A:
undetectable		 1oltA-4il1A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k0r CRYPTOCHROME-1

(Mus musculus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		5 THR A 301
GLU A 103
GLY A 106
ILE A  98
ALA A  20
 None
 1.38A 1oltA-4k0rA:
undetectable		 1oltA-4k0rA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnp N-ACETYLNEURAMINATE-
BINDING PROTEIN

(Fusobacterium
nucleatum) 		PF03480
(DctP) 		5 THR A  11
GLU A  18
ASP A  51
ILE A 211
TYR A 158
 SLB  A 401 (-4.0A)
None
SLB  A 401 (-3.3A)
None
None
 1.38A 1oltA-4mnpA:
undetectable		 1oltA-4mnpA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oht SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00171
(Aldedh) 		5 THR A   5
ASP A  73
GLY A  75
ALA A 312
GLN A 309
 None
 1.28A 1oltA-4ohtA:
undetectable		 1oltA-4ohtA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 GLY A  53
ASP A  52
ILE A 128
TYR A  16
ALA A  15
 None
 1.27A 1oltA-4qmeA:
undetectable		 1oltA-4qmeA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qwp CHITOSANASE

(Pseudomonas sp.
A-01) 		PF01374
(Glyco_hydro_46) 		5 THR A 206
ASP A 210
PHE A 144
TYR A 146
ALA A 129
 None
 1.24A 1oltA-4qwpA:
undetectable		 1oltA-4qwpA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 CYH A1715
THR A1790
GLY A1738
ILE A1727
PHE A1728
 None
AOV  A4401 ( 4.6A)
None
None
None
 1.35A 1oltA-4rh7A:
undetectable		 1oltA-4rh7A:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rz9 PRE-MRNA-SPLICING
FACTOR 38A

(Homo sapiens) 		PF03371
(PRP38) 		5 THR A 110
GLY A 103
ILE A 148
PHE A 147
TYR A 124
 None
 1.36A 1oltA-4rz9A:
undetectable		 1oltA-4rz9A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2r 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Actinomyces
urogenitalis) 		PF00977
(His_biosynth) 		5 THR A 164
ASP A 128
GLY A  21
ARG A 137
ALA A  15
 None
None
None
PO4  A 303 (-4.0A)
None
 1.26A 1oltA-4x2rA:
4.9		 1oltA-4x2rA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9r OMEGA-3
POLYUNSATURATED
FATTY ACID SYNTHASE
SUBUNIT PFAD

(Shewanella
oneidensis) 		PF03060
(NMO) 		5 THR A 269
GLU A 271
GLY A 107
ILE A 337
ALA A 489
 None
FMN  A 602 (-3.3A)
FMN  A 602 (-3.2A)
None
None
 1.28A 1oltA-4z9rA:
undetectable		 1oltA-4z9rA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 THR A 239
ASP A 237
GLY A 235
ILE A 209
ALA A 223
 None
RIP  A 301 (-2.8A)
None
None
None
 1.38A 1oltA-4zjpA:
undetectable		 1oltA-4zjpA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkt BONTOXILYSIN A

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		5 ASP A 338
GLY A 257
ASP A 259
ILE A 263
PHE A 252
 None
 1.16A 1oltA-4zktA:
undetectable		 1oltA-4zktA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrx F5/8 TYPE C DOMAIN
PROTEIN

(Bacteroides
ovatus) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		5 THR A 590
ASP A 588
ILE A 560
PHE A 557
ALA A 523
 None
 1.33A 1oltA-4zrxA:
undetectable		 1oltA-4zrxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zv4 ELONGATION FACTOR TU

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ASP A  87
ASP A  51
ILE A  50
PHE A  47
ALA A  31
 None
GDP  A 501 ( 4.6A)
None
None
None
 1.38A 1oltA-4zv4A:
undetectable		 1oltA-4zv4A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		5 ASP A 871
GLY A 869
ARG A 989
ILE A 990
ALA A1003
 None
 0.92A 1oltA-5d0fA:
undetectable		 1oltA-5d0fA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 GLU B 503
ASP B 466
ILE B 468
TYR B 472
GLN B 667
 None
 1.32A 1oltA-5do7B:
undetectable		 1oltA-5do7B:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyb DNA-BINDING PROTEIN
REB1

(Schizosaccharomyces
pombe) 		PF00249
(Myb_DNA-binding) 		5 GLY A 239
ARG A 294
ASP A 240
ALA A 158
GLN A 244
 None
 1.30A 1oltA-5eybA:
undetectable		 1oltA-5eybA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ft3 GLUTATHIONE
S-TRANSFERASE
EPSILON 2

(Aedes aegypti) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 THR A 144
ASP A 159
ILE A 157
TYR A  86
GLN A  93
 None
 1.16A 1oltA-5ft3A:
undetectable		 1oltA-5ft3A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwn PROTEIN RCC2

(Homo sapiens) 		PF00415
(RCC1) 		5 GLY A 492
ILE A 108
PHE A 109
TYR A 517
GLN A 134
 None
 1.22A 1oltA-5gwnA:
undetectable		 1oltA-5gwnA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 5 GLY A 475
ARG A 482
ILE A 336
PHE A 473
TYR A 331
 None
 1.31A 1oltA-5id6A:
undetectable		 1oltA-5id6A:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 THR A 854
ASP A 855
GLY A 857
ILE A 759
GLN A 787
 6HJ  A1101 (-3.9A)
6HJ  A1101 (-4.3A)
None
None
None
 1.27A 1oltA-5j9zA:
undetectable		 1oltA-5j9zA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jow NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43A

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 CYH A 163
GLU A 135
ASP A 166
GLY A 170
ILE A 107
 None
None
None
EDO  A 608 ( 4.7A)
None
 1.36A 1oltA-5jowA:
undetectable		 1oltA-5jowA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		5 GLY A 655
ASP A 656
TYR A 509
ALA A 505
GLN A 497
 None
 1.32A 1oltA-5nnpA:
undetectable		 1oltA-5nnpA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLU A 355
ASP A 320
GLY A 287
ARG A 280
ASP A 286
 None
 1.38A 1oltA-5tf0A:
undetectable		 1oltA-5tf0A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u84 ACID CERAMIDASE

(Balaenoptera
acutorostrata) 		no annotation 5 THR A 141
GLU A 138
ARG A 159
ILE A 282
PHE A 281
 None
I3C  A 412 (-2.7A)
None
None
None
 1.39A 1oltA-5u84A:
undetectable		 1oltA-5u84A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0t PROTEIN MSP1

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 CYH A 137
THR A 140
ASP A 192
GLY A 233
ILE A 238
 EDO  A 405 (-3.7A)
None
None
None
EDO  A 404 ( 4.9A)
 1.31A 1oltA-5w0tA:
undetectable		 1oltA-5w0tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7w NUCLEAR RECEPTOR
COACTIVATOR 1

(Mus musculus) 		no annotation 5 THR A 269
ASP A 267
ILE A 296
PHE A 299
TYR A 297
 None
 1.15A 1oltA-5y7wA:
undetectable		 1oltA-5y7wA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykd D-HYDANTOINASE/DIHYD
ROPYRIMIDINASE

(Pseudomonas
aeruginosa) 		no annotation 5 CYH A 319
THR A  60
ASP A  57
GLY A  82
ALA A 406
 None
 1.28A 1oltA-5ykdA:
2.7		 1oltA-5ykdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c43 GAMMA-AMINOBUTYRALDE
HYDE DEHYDROGENASE

(Salmonella
enterica) 		no annotation 5 THR A 281
ASP A 279
GLY A 277
ALA A 303
GLN A 266
 None
 1.17A 1oltA-6c43A:
undetectable		 1oltA-6c43A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk TARGET OF RAPAMYCIN
COMPLEX SUBUNIT LST8

(Saccharomyces
cerevisiae) 		no annotation 5 ASP B 271
GLY B 248
ARG B 275
ASP B 247
ALA B 223
 None
 1.26A 1oltA-6emkB:
undetectable		 1oltA-6emkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn0 -

(-) 		no annotation 5 ASP A 389
ARG A 360
ILE A 345
PHE A 434
ALA A 335
 FAD  A 501 (-3.8A)
FAD  A 501 (-4.0A)
None
None
None
 1.19A 1oltA-6fn0A:
undetectable		 1oltA-6fn0A:
undetectable