SIMILAR PATTERNS OF AMINO ACIDS FOR 1OIP_A_VIVA1278_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		4 SER A 205
SER A 207
VAL A  67
PHE A  90
 None
 1.35A 1oipA-1b74A:
1.0		 1oipA-1b74A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		4 SER A  55
PHE A  17
VAL A 147
PHE A 140
 None
 1.36A 1oipA-1dtpA:
undetectable		 1oipA-1dtpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 SER A 237
SER A 239
VAL A 316
PHE A 314
 None
 1.14A 1oipA-1e8tA:
undetectable		 1oipA-1e8tA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 SER A 368
SER A 394
PHE A 254
PHE A 436
 PIN  A 506 ( 3.8A)
None
None
None
 1.42A 1oipA-1ecgA:
undetectable		 1oipA-1ecgA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		4 SER A  61
PHE A   7
VAL A  18
PHE A  20
 None
 1.05A 1oipA-1mgtA:
undetectable		 1oipA-1mgtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 SER A 238
SER A 242
PHE A 371
PHE A 152
 SO4  A 593 (-1.9A)
None
I40  A 997 (-4.9A)
None
 1.46A 1oipA-1qonA:
0.4		 1oipA-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 SER A 134
SER A 138
VAL A 164
PHE A 161
 FMT  A3013 (-2.6A)
None
None
None
 0.95A 1oipA-1r4pA:
undetectable		 1oipA-1r4pA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 SER A 136
SER A 140
PHE A 158
VAL A 182
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 (-3.9A)
 0.28A 1oipA-1r5lA:
43.4		 1oipA-1r5lA:
93.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 SER A 137
SER A 138
VAL A  99
PHE A  57
 None
 1.20A 1oipA-1thgA:
1.9		 1oipA-1thgA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 382
SER A 209
VAL A 349
PHE A 358
 None
 1.08A 1oipA-1xmbA:
undetectable		 1oipA-1xmbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 SER A 100
SER A 103
PHE A 128
VAL A  74
 None
 1.34A 1oipA-1yvpA:
2.9		 1oipA-1yvpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		4 SER A 213
SER A 227
PHE A 157
VAL A 269
 None
 1.23A 1oipA-2abqA:
undetectable		 1oipA-2abqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN

(Escherichia
coli) 		PF02635
(DrsE) 		4 SER A  18
SER A  19
VAL A   7
PHE A 128
 None
 1.03A 1oipA-2d1pA:
undetectable		 1oipA-2d1pA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j13 POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		4 SER A 106
SER A 104
VAL A 113
PHE A 110
 None
 1.41A 1oipA-2j13A:
undetectable		 1oipA-2j13A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1s INNER MEMBRANE
LIPOPROTEIN YIAD

(Escherichia
coli) 		PF00691
(OmpA) 		4 SER A  93
SER A  96
PHE A  38
VAL A  70
 None
 1.48A 1oipA-2k1sA:
undetectable		 1oipA-2k1sA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 SER A 436
PHE A 281
VAL A 451
PHE A 452
 None
 1.31A 1oipA-2qpmA:
undetectable		 1oipA-2qpmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		4 SER A 163
SER A 161
VAL A  94
PHE A 127
 GDP  A 188 (-4.2A)
None
None
None
 1.48A 1oipA-2x77A:
undetectable		 1oipA-2x77A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER B 122
SER B 147
PHE B 143
VAL B 195
 None
 1.03A 1oipA-2z7xB:
1.4		 1oipA-2z7xB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 SER A  26
SER A  31
PHE A 111
VAL A  70
 None
 1.28A 1oipA-3a2kA:
undetectable		 1oipA-3a2kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 SER A 638
SER A 642
VAL A 585
PHE A 589
 None
 0.86A 1oipA-3aqpA:
undetectable		 1oipA-3aqpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Bacillus
subtilis) 		PF06508
(QueC) 		4 SER A 103
SER A 106
PHE A 136
PHE A 152
 None
 1.19A 1oipA-3bl5A:
undetectable		 1oipA-3bl5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 SER A 185
PHE A 278
VAL A 191
PHE A 194
 None
 1.30A 1oipA-3clqA:
undetectable		 1oipA-3clqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwx PROTEIN CAGD

(Helicobacter
pylori) 		PF16567
(CagD) 		4 SER A 111
SER A 113
VAL A  63
PHE A  60
 None
 1.26A 1oipA-3cwxA:
undetectable		 1oipA-3cwxA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 SER A 154
PHE A 182
VAL A 200
PHE A  77
 None
 1.49A 1oipA-3evzA:
undetectable		 1oipA-3evzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		4 SER A 285
PHE A  68
VAL A 341
PHE A 340
 None
EDO  A 364 ( 3.5A)
None
None
 1.47A 1oipA-3ianA:
2.6		 1oipA-3ianA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 SER A 421
SER A 399
PHE A 461
VAL A 494
 None
 1.41A 1oipA-3iu1A:
undetectable		 1oipA-3iu1A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 4 SER A 368
PHE A 467
VAL A 371
PHE A 333
 None
 1.20A 1oipA-3nlcA:
undetectable		 1oipA-3nlcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1

(Homo sapiens) 		PF00617
(RasGEF) 		4 SER A 146
SER A 150
PHE A  98
VAL A 105
 None
 1.04A 1oipA-3qxlA:
undetectable		 1oipA-3qxlA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1
GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA)
PF04670
(Gtr1_RagA) 		4 SER B 273
PHE A 213
VAL B 237
PHE B 234
 None
 1.25A 1oipA-3r7wB:
undetectable		 1oipA-3r7wB:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 SER A 235
PHE A 319
VAL A 285
PHE A 277
 None
 1.10A 1oipA-3tqiA:
undetectable		 1oipA-3tqiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujk PROTEIN PHOSPHATASE
2C 77

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 SER A 232
SER A 234
VAL A 216
PHE A 213
 None
 1.49A 1oipA-3ujkA:
undetectable		 1oipA-3ujkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		4 SER A 197
PHE A 192
VAL A 170
PHE A 169
 None
None
None
ADN  A 401 (-3.7A)
 1.32A 1oipA-3vasA:
undetectable		 1oipA-3vasA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3von UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF10275
(Peptidase_C65) 		4 SER A 180
PHE A 130
VAL A 200
PHE A 203
 None
 1.30A 1oipA-3vonA:
undetectable		 1oipA-3vonA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccv HISTIDINE-RICH
GLYCOPROTEIN

(Oryctolagus
cuniculus) 		no annotation 4 SER A 139
PHE A 205
VAL A 178
PHE A 180
 None
 1.17A 1oipA-4ccvA:
undetectable		 1oipA-4ccvA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 203
SER A 207
VAL A 324
PHE A 301
 None
 1.22A 1oipA-4jbhA:
undetectable		 1oipA-4jbhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE

([Clostridium]
scindens) 		PF00501
(AMP-binding) 		4 SER A 206
SER A 209
PHE A  19
PHE A 264
 None
 1.26A 1oipA-4lgcA:
undetectable		 1oipA-4lgcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		4 SER A 366
PHE A 355
VAL A 335
PHE A 290
 None
 1.09A 1oipA-4lk4A:
undetectable		 1oipA-4lk4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A  93
SER A  94
VAL A  45
PHE A  42
 None
 1.46A 1oipA-4m7eA:
undetectable		 1oipA-4m7eA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 SER A 445
SER A 441
PHE A 381
PHE A 385
 None
SO4  A 701 (-3.7A)
None
None
 1.46A 1oipA-4nbqA:
2.6		 1oipA-4nbqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 SER D 351
SER D 350
VAL D 378
PHE D 389
 None
 1.38A 1oipA-4ngeD:
undetectable		 1oipA-4ngeD:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN

(Aeropyrum
pernix) 		PF02608
(Bmp) 		4 SER A 321
SER A 359
PHE A 288
VAL A 390
 None
 1.45A 1oipA-4pevA:
undetectable		 1oipA-4pevA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 SER A 482
PHE A 500
VAL A 442
PHE A 443
 None
 1.30A 1oipA-4q6rA:
undetectable		 1oipA-4q6rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 SER A 223
SER A 227
PHE A 100
VAL A  34
 None
 1.28A 1oipA-4ql6A:
3.1		 1oipA-4ql6A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 SER A 234
PHE A 222
VAL A 172
PHE A 236
 None
 1.45A 1oipA-4wy8A:
2.6		 1oipA-4wy8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		4 SER A 145
SER A 146
VAL A 132
PHE A 130
 None
 1.36A 1oipA-5cbmA:
undetectable		 1oipA-5cbmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 SER A 356
SER A 360
PHE A 294
VAL A 301
 None
 1.04A 1oipA-5cm9A:
undetectable		 1oipA-5cm9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5b FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 SER A  37
SER A  49
VAL A 136
PHE A 137
 None
 1.22A 1oipA-5e5bA:
undetectable		 1oipA-5e5bA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		4 SER A 267
SER A 268
PHE A  75
PHE A 264
 None
 1.24A 1oipA-5ftfA:
undetectable		 1oipA-5ftfA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 SER A  55
PHE A 521
VAL A   9
PHE A  14
 None
 1.21A 1oipA-5fxeA:
undetectable		 1oipA-5fxeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3u PROTEIN KINASE A

(Toxoplasma
gondii) 		PF00027
(cNMP_binding) 		4 SER A 386
PHE A 164
VAL A 323
PHE A 324
 None
 1.49A 1oipA-5j3uA:
undetectable		 1oipA-5j3uA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 SER A 136
SER A 140
PHE A 158
VAL A 182
PHE A 187
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.4A)
VIV  A 302 (-4.0A)
 0.22A 1oipA-5mueA:
39.1		 1oipA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A

(Danio rerio;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 SER A 306
PHE A  52
VAL A 301
PHE A 304
 None
 1.40A 1oipA-5xszA:
undetectable		 1oipA-5xszA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 SER A 158
SER A  60
VAL A 155
PHE A 154
 None
 1.35A 1oipA-5zqeA:
undetectable		 1oipA-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1

(Homo sapiens;
Gallus gallus) 		no annotation
no annotation 		4 SER A1043
PHE A1058
VAL A1101
PHE B  55
 None
 1.46A 1oipA-6c7yA:
undetectable		 1oipA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czp OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Vibrio
vulnificus) 		no annotation 4 SER A  43
SER A  40
VAL A 125
PHE A 124
 None
 1.44A 1oipA-6czpA:
undetectable		 1oipA-6czpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 4 SER A 440
SER A 441
PHE A 489
VAL A 516
 None
 1.41A 1oipA-6etiA:
2.8		 1oipA-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 SER A 742
SER A 741
VAL A 731
PHE A 393
 None
 1.23A 1oipA-6fikA:
undetectable		 1oipA-6fikA:
undetectable