SIMILAR PATTERNS OF AMINO ACIDS FOR 1OIP_A_VIVA1278

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d4e FLAVOCYTOCHROME C
FUMARATE REDUCTASE

(Shewanella
oneidensis) 		PF00890
(FAD_binding_2)
PF14537
(Cytochrom_c3_2) 		5 ILE A 375
VAL A 440
LEU A 488
VAL A 464
ILE A 385
 None
 1.06A 1oipA-1d4eA:
undetectable		 1oipA-1d4eA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4y ADENYLATE KINASE

(Escherichia
coli) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 ILE A  26
ILE A   3
LEU A 107
ILE A 212
ILE A  20
 None
 0.88A 1oipA-1e4yA:
undetectable		 1oipA-1e4yA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef9 METHYLMALONYL COA
DECARBOXYLASE

(Escherichia
coli) 		PF00378
(ECH_1) 		5 VAL A 107
LEU A  36
VAL A   6
ILE A  17
ILE A  92
 None
 1.03A 1oipA-1ef9A:
4.6		 1oipA-1ef9A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE

(Hydrogenophaga
pseudoflava) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU B 576
ILE B 534
LEU B 538
ILE B 507
ILE B 545
 None
 0.98A 1oipA-1ffvB:
undetectable		 1oipA-1ffvB:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii0 ARSENICAL
PUMP-DRIVING ATPASE

(Escherichia
coli) 		PF02374
(ArsA_ATPase) 		5 VAL A 202
ILE A   7
ILE A 140
LEU A  41
VAL A  50
 None
 0.75A 1oipA-1ii0A:
undetectable		 1oipA-1ii0A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jeo HYPOTHETICAL PROTEIN
MJ1247

(Methanocaldococcus
jannaschii) 		PF01380
(SIS) 		5 ILE A  16
ILE A  87
ILE A 115
VAL A 134
ILE A  89
 None
None
None
CME  A 117 ( 4.7A)
None
 0.98A 1oipA-1jeoA:
undetectable		 1oipA-1jeoA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhj APC10

(Homo sapiens) 		PF03256
(ANAPC10) 		5 ILE A 108
ILE A  79
LEU A  77
ILE A 137
ILE A 156
 None
 1.06A 1oipA-1jhjA:
undetectable		 1oipA-1jhjA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9w GENERAL SECRETION
PATHWAY PROTEIN E

(Vibrio cholerae) 		PF00437
(T2SSE) 		5 ILE A 153
ILE A 142
LEU A 226
VAL A 207
ILE A 135
 None
 0.87A 1oipA-1p9wA:
undetectable		 1oipA-1p9wA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdn PROTEIN (PRD PAIRED)

(Drosophila
melanogaster) 		PF00292
(PAX) 		5 ILE C  99
LEU C 103
VAL C 108
ILE C  80
ILE C 120
 None
 1.03A 1oipA-1pdnC:
undetectable		 1oipA-1pdnC:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pk9 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Escherichia
coli) 		PF01048
(PNP_UDP_1) 		5 ILE A 199
ILE A  57
LEU A  17
VAL A  88
ILE A 225
 None
 0.98A 1oipA-1pk9A:
undetectable		 1oipA-1pk9A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3x MANNAN-BINDING
LECTIN SERINE
PROTEASE 2

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 ILE A 652
ILE A 548
ILE A 536
LEU A 538
VAL A 542
 None
 1.06A 1oipA-1q3xA:
undetectable		 1oipA-1q3xA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8f PYRIMIDINE
NUCLEOSIDE HYDROLASE

(Escherichia
coli) 		PF01156
(IU_nuc_hydro) 		5 ILE A 130
ILE A   6
LEU A  31
VAL A  61
ILE A  34
 None
 0.99A 1oipA-1q8fA:
1.9		 1oipA-1q8fA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhx PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)

(Streptomyces
venezuelae) 		PF07931
(CPT) 		5 ILE A   6
LEU A   8
VAL A 119
ILE A  19
ILE A  90
 None
 0.83A 1oipA-1qhxA:
undetectable		 1oipA-1qhxA:
19.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
ILE A 154
ILE A 171
ILE A 179
LEU A 183
VAL A 191
ILE A 194
ILE A 210
 None
None
None
VIV  A 301 ( 4.7A)
VIV  A 301 ( 4.8A)
None
None
VIV  A 301 ( 4.0A)
None
VIV  A 301 (-4.7A)
VIV  A 301 ( 4.5A)
None
 0.23A 1oipA-1r5lA:
43.4		 1oipA-1r5lA:
93.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzr GLUCOSE-RESISTANCE
AMYLASE REGULATOR

(Bacillus
megaterium) 		no annotation 5 ILE G  73
ILE G 121
LEU G  95
VAL G  65
ILE G  67
 None
 0.99A 1oipA-1rzrG:
undetectable		 1oipA-1rzrG:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usv AHA1

(Saccharomyces
cerevisiae) 		PF09229
(Aha1_N) 		5 ILE B  50
VAL B  98
ILE B 127
ILE B 138
ILE B  44
 None
 1.00A 1oipA-1usvB:
undetectable		 1oipA-1usvB:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp3 ENDONUCLEASE IV

(Bacillus
anthracis) 		PF01261
(AP_endonuc_2) 		5 ILE A 127
LEU A 131
VAL A 134
ILE A 143
ILE A 165
 None
 0.96A 1oipA-1xp3A:
undetectable		 1oipA-1xp3A:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 ILE A 275
LEU A 264
VAL A 241
ILE A 237
ILE A 296
 None
 0.76A 1oipA-1xszA:
undetectable		 1oipA-1xszA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y6l UBIQUITIN-CONJUGATIN
G ENZYME E2E2

(Homo sapiens) 		PF00179
(UQ_con) 		5 ILE A  54
ILE A  88
LEU A  89
VAL A  67
ILE A 106
 None
 1.05A 1oipA-1y6lA:
undetectable		 1oipA-1y6lA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		5 ILE A 133
ILE A   7
LEU A 304
VAL A 307
ILE A 312
 None
 0.89A 1oipA-1z26A:
undetectable		 1oipA-1z26A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew9 COPPER-TRANSPORTING
ATPASE 2

(Homo sapiens) 		PF00403
(HMA) 		5 ILE A  53
ILE A  22
LEU A  26
VAL A  32
ILE A  46
 None
 0.98A 1oipA-2ew9A:
undetectable		 1oipA-2ew9A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fph YLMH

(Streptococcus
pneumoniae) 		no annotation 5 ILE X 155
ILE X 108
LEU X 149
VAL X 157
ILE X  94
 None
 0.94A 1oipA-2fphX:
undetectable		 1oipA-2fphX:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ILE A 608
ILE A 631
ILE A 638
LEU A 692
VAL A 657
 None
 0.87A 1oipA-2g3nA:
2.0		 1oipA-2g3nA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfq UPF0204 PROTEIN
PH0006

(Pyrococcus
horikoshii) 		PF04414
(tRNA_deacylase) 		5 ILE A  16
ILE A 175
LEU A 179
ILE A  73
ILE A   4
 None
 1.01A 1oipA-2gfqA:
undetectable		 1oipA-2gfqA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE

(Agrobacterium
tumefaciens) 		PF01261
(AP_endonuc_2) 		5 ILE A  40
ILE A 136
LEU A  93
VAL A  96
ILE A 104
 ILE  A  40 ( 0.7A)
ILE  A 136 ( 0.6A)
LEU  A  93 ( 0.6A)
VAL  A  96 ( 0.6A)
ILE  A 104 ( 0.7A)
 1.01A 1oipA-2hk0A:
undetectable		 1oipA-2hk0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		5 LEU A  76
ILE A  51
LEU A  52
VAL A  67
ILE A  37
 None
 0.97A 1oipA-2qm3A:
2.1		 1oipA-2qm3A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9v ATP SYNTHASE SUBUNIT
ALPHA

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 ILE A 130
ILE A 338
LEU A 264
VAL A 335
ILE A 199
 None
 0.96A 1oipA-2r9vA:
2.0		 1oipA-2r9vA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uuu ALKYLDIHYDROXYACETON
EPHOSPHATE SYNTHASE

(Dictyostelium
discoideum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 TYR A 466
VAL A 505
ILE A 351
ILE A 419
ILE A 400
 None
 1.02A 1oipA-2uuuA:
undetectable		 1oipA-2uuuA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6v PEROXISOMAL MEMBRANE
PROTEIN LPX1

(Saccharomyces
cerevisiae) 		PF12697
(Abhydrolase_6) 		5 ILE A  86
ILE A 124
ILE A 337
ILE A 142
VAL A 121
 None
CME  A  13 ( 4.9A)
None
None
None
 0.93A 1oipA-2y6vA:
3.0		 1oipA-2y6vA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zts PUTATIVE
UNCHARACTERIZED
PROTEIN PH0186

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		5 ILE A 198
ILE A 157
ILE A 147
VAL A  97
ILE A 127
 None
 0.92A 1oipA-2ztsA:
2.3		 1oipA-2ztsA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		5 ILE A 277
ILE A 269
VAL A 274
ILE A  35
ILE A  49
 None
 1.05A 1oipA-3a5vA:
undetectable		 1oipA-3a5vA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bws PROTEIN LP49

(Leptospira
interrogans) 		PF10282
(Lactonase) 		5 ILE A 322
LEU A 308
VAL A 342
ILE A 340
ILE A 310
 None
 0.99A 1oipA-3bwsA:
undetectable		 1oipA-3bwsA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doh ESTERASE

(Thermotoga
maritima) 		PF02230
(Abhydrolase_2) 		5 LEU A 130
ILE A  42
LEU A  53
VAL A  96
ILE A  48
 None
 0.86A 1oipA-3dohA:
3.9		 1oipA-3dohA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		5 ILE A  21
ILE A 217
LEU A 221
VAL A 227
ILE A 179
 None
 0.85A 1oipA-3ek1A:
undetectable		 1oipA-3ek1A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfo COBALT IMPORT
ATP-BINDING PROTEIN
CBIO 1

(Clostridium
perfringens) 		PF00005
(ABC_tran) 		5 ILE A 197
ILE A 180
ILE A 152
LEU A 156
ILE A 193
 None
 0.86A 1oipA-3gfoA:
2.7		 1oipA-3gfoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4m PROTEASOME-ACTIVATIN
G NUCLEOTIDASE

(Methanocaldococcus
jannaschii) 		PF00004
(AAA) 		5 TYR A 169
ILE A 172
LEU A 190
ILE A 313
ILE A 336
 None
ADP  A 439 (-4.7A)
None
None
None
 0.94A 1oipA-3h4mA:
3.8		 1oipA-3h4mA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3now UNC-45 PROTEIN,
SD10334P

(Drosophila
melanogaster) 		PF11701
(UNC45-central) 		5 ILE A 625
ILE A 652
LEU A 656
VAL A 659
ILE A 633
 None
 1.05A 1oipA-3nowA:
undetectable		 1oipA-3nowA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o21 GLUTAMATE RECEPTOR 3

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		5 ILE A 178
ILE A 198
LEU A 202
VAL A 205
ILE A 227
 None
 1.02A 1oipA-3o21A:
undetectable		 1oipA-3o21A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 5 LEU A 427
LEU A 201
VAL A 436
ILE A 279
ILE A 251
 None
 0.93A 1oipA-3pf7A:
undetectable		 1oipA-3pf7A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum) 		PF00224
(PK)
PF02887
(PK_C) 		5 VAL A 227
ILE A  61
LEU A  49
VAL A  57
ILE A 190
 None
 0.97A 1oipA-3qtgA:
2.6		 1oipA-3qtgA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s69 THROMBIN-LIKE ENZYME
DEFIBRASE

(Gloydius
saxatilis) 		PF00089
(Trypsin) 		5 ILE A 208
ILE A 117
ILE A 105
LEU A 107
VAL A 111
 None
 1.00A 1oipA-3s69A:
undetectable		 1oipA-3s69A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s7i ALLERGEN ARA H 1,
CLONE P41B

(Arachis
hypogaea) 		PF00190
(Cupin_1) 		5 VAL A 247
ILE A 274
LEU A 283
ILE A 238
ILE A 217
 None
 1.06A 1oipA-3s7iA:
undetectable		 1oipA-3s7iA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		5 ILE A  35
ILE A  47
LEU A  98
VAL A  61
ILE A  63
 None
 0.88A 1oipA-3vylA:
undetectable		 1oipA-3vylA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2

(Pyrococcus
furiosus) 		PF12469
(DUF3692) 		5 ILE A 226
ILE A 224
LEU A 222
VAL A 306
ILE A 314
 None
 0.86A 1oipA-3x1lA:
undetectable		 1oipA-3x1lA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zto NUCLEOSIDE
DIPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00334
(NDK) 		5 ILE A  89
ILE A  34
LEU A  77
VAL A  86
ILE A   8
 None
 0.75A 1oipA-3ztoA:
undetectable		 1oipA-3ztoA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1l 2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus) 		PF00793
(DAHP_synth_1) 		5 LEU A 179
ILE A 143
ILE A  27
ILE A 196
VAL A 187
 None
 0.93A 1oipA-4c1lA:
undetectable		 1oipA-4c1lA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila) 		PF01369
(Sec7) 		5 ILE A 275
LEU A 264
VAL A 241
ILE A 237
ILE A 296
 None
 0.79A 1oipA-4c7pA:
undetectable		 1oipA-4c7pA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7r PROLINE/BETAINE
TRANSPORTER, RALF

(Legionella
pneumophila;
Rickettsia
prowazekii) 		PF01369
(Sec7) 		5 ILE A 273
LEU A 262
VAL A 239
ILE A 235
ILE A 294
 None
 0.77A 1oipA-4d7rA:
undetectable		 1oipA-4d7rA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dao PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE

(Bacillus
subtilis) 		PF01048
(PNP_UDP_1) 		5 ILE A 198
ILE A  57
LEU A  17
VAL A  88
ILE A 224
 None
 0.97A 1oipA-4daoA:
undetectable		 1oipA-4daoA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dhi UBIQUITIN
THIOESTERASE
OTUBAIN-LIKE

(Caenorhabditis
elegans) 		PF10275
(Peptidase_C65) 		5 ILE B 248
LEU B 261
VAL B 229
ILE B  93
ILE B  82
 None
 1.01A 1oipA-4dhiB:
undetectable		 1oipA-4dhiB:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ILE A1143
ILE A1238
ILE A1270
LEU A1110
VAL A1288
 None
 1.04A 1oipA-4f4cA:
undetectable		 1oipA-4f4cA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 B CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE H 652
ILE H 548
ILE H 536
LEU H 538
VAL H 542
 None
 1.03A 1oipA-4fxgH:
undetectable		 1oipA-4fxgH:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6v ADHESIN/HEMOLYSIN

(Burkholderia
pseudomallei) 		no annotation 5 ILE A 269
LEU A 277
VAL A 243
ILE A 251
ILE A 292
 None
 0.99A 1oipA-4g6vA:
undetectable		 1oipA-4g6vA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 LEU A 250
ILE A 214
ILE A  98
ILE A 267
VAL A 258
 None
 1.03A 1oipA-4grsA:
undetectable		 1oipA-4grsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		5 LEU A 313
ILE A 416
ILE A 434
ILE A 421
ILE A 451
 None
 1.06A 1oipA-4gz8A:
undetectable		 1oipA-4gz8A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		5 ILE A  30
LEU A 139
ILE A 112
LEU A  96
VAL A 116
 None
 0.99A 1oipA-4hjwA:
2.9		 1oipA-4hjwA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ipe TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 ILE A 213
ILE A 158
LEU A 160
ILE A 128
ILE A 300
 None
 1.07A 1oipA-4ipeA:
2.0		 1oipA-4ipeA:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix1 HYPOTHETICAL PROTEIN

(Rhodococcus
opacus) 		no annotation 5 ILE A 217
ILE A 119
LEU A 150
VAL A 157
ILE A 133
 None
 1.07A 1oipA-4ix1A:
undetectable		 1oipA-4ix1A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j2u ENOYL-COA HYDRATASE

(Rhodobacter
sphaeroides) 		PF16113
(ECH_2) 		5 VAL A 145
ILE A  95
LEU A  38
ILE A  15
ILE A 102
 None
 1.02A 1oipA-4j2uA:
5.0		 1oipA-4j2uA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kgb SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE

(Drosophila
melanogaster) 		PF01144
(CoA_trans) 		5 ILE A 301
ILE A 434
LEU A 480
ILE A 448
ILE A 462
 None
 0.95A 1oipA-4kgbA:
undetectable		 1oipA-4kgbA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 TYR A 133
ILE A 237
VAL A 180
ILE A 145
ILE A 223
 None
 1.01A 1oipA-4l9rA:
2.2		 1oipA-4l9rA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pht GENERAL SECRETORY
PATHWAY PROTEIN E

(Vibrio
vulnificus) 		PF00437
(T2SSE) 		5 ILE A 149
ILE A 138
LEU A 222
VAL A 203
ILE A 131
 None
 0.77A 1oipA-4phtA:
undetectable		 1oipA-4phtA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pve POLLEN ALLERGEN PHL
P 4.0202

(Phleum pratense) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A 204
ILE A  79
LEU A 106
VAL A 104
ILE A  65
 None
None
FAD  A 601 (-4.8A)
None
None
 0.90A 1oipA-4pveA:
undetectable		 1oipA-4pveA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 ILE A 407
VAL A 200
ILE A 307
ILE A 233
VAL A 296
 None
 0.72A 1oipA-4qg5A:
undetectable		 1oipA-4qg5A:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		5 ILE A 281
ILE A 275
LEU A 291
ILE A 287
ILE A 269
 None
None
None
CL  A 402 ( 4.4A)
None
 1.06A 1oipA-4rk1A:
undetectable		 1oipA-4rk1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rk1 RIBOSE
TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecium) 		PF13377
(Peripla_BP_3) 		5 LEU A 250
ILE A 281
ILE A 275
LEU A 291
ILE A 269
 None
 0.92A 1oipA-4rk1A:
undetectable		 1oipA-4rk1A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rn7 N-ACETYLMURAMOYL-L-A
LANINE AMIDASE

(Clostridioides
difficile) 		PF01520
(Amidase_3) 		5 ILE A 148
LEU A 283
VAL A 235
ILE A 208
ILE A 194
 None
 0.98A 1oipA-4rn7A:
undetectable		 1oipA-4rn7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1l CARBOHYDRATE BINDING
MODULE

(Ruminococcus
flavefaciens) 		no annotation 5 ILE A 499
ILE A 570
ILE A 526
ILE A 532
ILE A 593
 None
GOL  A1627 (-4.6A)
None
None
None
 0.93A 1oipA-4v1lA:
undetectable		 1oipA-4v1lA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x4w CCA TRNA
NUCLEOTIDYLTRANSFERA
SE 1, MITOCHONDRIAL

(Homo sapiens) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		5 ILE A 232
ILE A 207
LEU A 204
VAL A 237
ILE A 172
 None
CL  A 505 ( 4.3A)
None
None
None
 1.03A 1oipA-4x4wA:
2.4		 1oipA-4x4wA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z85 2-NITROBENZOATE
NITROREDUCTASE

(Pseudomonas
fluorescens) 		PF01613
(Flavin_Reduct) 		5 VAL A 129
ILE A  96
ILE A  81
VAL A  92
ILE A  59
 None
 1.06A 1oipA-4z85A:
undetectable		 1oipA-4z85A:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 TRP A 195
VAL A 126
ILE A 161
LEU A 217
VAL A 225
 None
 0.87A 1oipA-4zxoA:
2.3		 1oipA-4zxoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4j FORMATE--TETRAHYDROF
OLATE LIGASE

(Tepidanaerobacter
acetatoxydans) 		PF01268
(FTHFS) 		5 ILE A  64
VAL A 395
ILE A 429
LEU A 422
VAL A 426
 None
None
PEG  A1563 ( 4.6A)
None
None
 1.01A 1oipA-5a4jA:
undetectable		 1oipA-5a4jA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab4 SCP2-THIOLASE LIKE
PROTEIN

(Trypanosoma
brucei) 		no annotation 5 ILE A 291
ILE A  91
LEU A  94
VAL A 220
ILE A 247
 None
 1.06A 1oipA-5ab4A:
undetectable		 1oipA-5ab4A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs5 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 ILE A 583
ILE A 711
ILE A 685
LEU A 669
ILE A 637
 None
 1.00A 1oipA-5bs5A:
undetectable		 1oipA-5bs5A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c93 HISTIDINE KINASE

(Lactobacillus
plantarum) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		5 ILE A 511
ILE A 605
LEU A 607
ILE A 499
ILE A 538
 None
 0.80A 1oipA-5c93A:
undetectable		 1oipA-5c93A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4

(Legionella
pneumophila) 		PF00023
(Ank)
PF00856
(SET) 		5 ILE A  92
ILE A 181
LEU A 209
VAL A 214
ILE A 147
 None
 1.02A 1oipA-5czyA:
undetectable		 1oipA-5czyA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dku PREX DNA POLYMERASE

(Plasmodium
falciparum) 		PF00476
(DNA_pol_A)
PF01612
(DNA_pol_A_exo1) 		5 ILE A  83
ILE A 181
ILE A 154
ILE A 157
ILE A 246
 None
 0.81A 1oipA-5dkuA:
undetectable		 1oipA-5dkuA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8z PLASMA KALLIKREIN
LIGHT CHAIN

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A  16
ILE A 176
LEU A 199
VAL A 138
ILE A 160
 None
 1.07A 1oipA-5f8zA:
undetectable		 1oipA-5f8zA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbh EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		no annotation 5 ILE B 292
ILE B 528
ILE B 523
LEU B 521
ILE B 491
 None
 0.99A 1oipA-5fbhB:
undetectable		 1oipA-5fbhB:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE

(Sulfolobus
solfataricus) 		PF01269
(Fibrillarin) 		5 ILE E 214
ILE E  74
LEU E  61
ILE E  65
ILE E  97
 None
 1.05A 1oipA-5ginE:
undetectable		 1oipA-5ginE:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjn LD10117P

(Drosophila
melanogaster) 		PF00566
(RabGAP-TBC) 		5 TYR A 112
VAL A 116
ILE A 130
LEU A 132
VAL A 136
 None
 0.69A 1oipA-5hjnA:
3.3		 1oipA-5hjnA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i9q 426C.TM4DV1-3 P120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU A 453
ILE A 272
ILE A 333
ILE A 449
LEU A 288
 None
 1.06A 1oipA-5i9qA:
undetectable		 1oipA-5i9qA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5t EXTRACELLULAR
CALCIUM-SENSING
RECEPTOR

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 ILE A 292
ILE A 528
ILE A 523
LEU A 521
ILE A 491
 None
 0.91A 1oipA-5k5tA:
undetectable		 1oipA-5k5tA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mp2 TYPE II SECRETION
SYSTEM PROTEIN D

(Pseudomonas
aeruginosa) 		no annotation 5 ILE A 253
ILE A 191
ILE A 160
LEU A 182
ILE A 198
 None
 0.98A 1oipA-5mp2A:
undetectable		 1oipA-5mp2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mq6 PYRIDINE
NUCLEOTIDE-DISULFIDE
OXIDOREDUCTASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF07992
(Pyr_redox_2) 		5 VAL A 112
ILE A 552
ILE A 109
LEU A  97
VAL A 553
 None
 1.03A 1oipA-5mq6A:
undetectable		 1oipA-5mq6A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		5 TRP A 722
LEU A1046
ILE A1043
LEU A1084
ILE A1086
 None
 1.01A 1oipA-5mqsA:
2.2		 1oipA-5mqsA:
12.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		12 TYR A 100
ILE A 119
TRP A 122
VAL A 132
LEU A 137
ILE A 154
ILE A 171
ILE A 179
LEU A 183
VAL A 191
ILE A 194
ILE A 210
 None
None
None
VIV  A 302 (-4.4A)
VIV  A 302 ( 4.8A)
None
VIV  A 302 ( 4.8A)
VIV  A 302 (-4.0A)
None
VIV  A 302 ( 4.9A)
VIV  A 302 ( 4.6A)
None
 0.19A 1oipA-5mueA:
39.1		 1oipA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng6 CRISPR-ASSOCIATED
ENDONUCLEASE CPF1

(Francisella
tularensis) 		no annotation 5 ILE A 195
LEU A 208
ILE A 278
LEU A  66
ILE A 113
 None
 0.88A 1oipA-5ng6A:
undetectable		 1oipA-5ng6A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3

(Homo sapiens) 		PF00069
(Pkinase)
PF12202
(OSR1_C) 		5 ILE A 396
ILE A 292
LEU A 295
ILE A 271
ILE A 206
 None
None
GOL  A 602 ( 4.9A)
None
None
 1.05A 1oipA-5o2cA:
undetectable		 1oipA-5o2cA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tth C-TERMINAL
SPYCATCHER FUSION OF
WILDTYPE ZEBRAFISH
TNF
RECEPTOR-ASSOCIATED
PROTEIN 1

(Streptococcus
pyogenes;
Danio rerio) 		PF00183
(HSP90)
PF13589
(HATPase_c_3) 		5 ILE A 213
ILE A 158
LEU A 160
ILE A 128
ILE A 300
 None
 1.06A 1oipA-5tthA:
2.0		 1oipA-5tthA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		5 LEU A 157
ILE A 181
LEU A 183
ILE A 196
ILE A 213
 None
 0.91A 1oipA-5ul4A:
undetectable		 1oipA-5ul4A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5upy INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Listeria
monocytogenes) 		PF00478
(IMPDH) 		5 ILE A  63
ILE A 338
ILE A 350
LEU A 354
ILE A 439
 None
 0.83A 1oipA-5upyA:
undetectable		 1oipA-5upyA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ILE A 438
LEU A 550
ILE A 619
LEU A 590
ILE A 531
 None
 1.06A 1oipA-5vniA:
2.2		 1oipA-5vniA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zby HYDROGENASE
MATURATION PROTEASE
HYCI

(Thermococcus
kodakarensis) 		no annotation 5 ILE A  87
ILE A 154
LEU A 155
VAL A  46
ILE A  16
 None
 0.84A 1oipA-5zbyA:
undetectable		 1oipA-5zbyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c08 SODIUM-COUPLED
NEUTRAL AMINO ACID
TRANSPORTER 9

(Danio rerio) 		no annotation 5 ILE C 494
LEU C 393
ILE C 314
VAL C 317
ILE C 413
 None
 1.00A 1oipA-6c08C:
undetectable		 1oipA-6c08C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 GP120 OF ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU G 453
ILE G 272
ILE G 333
ILE G 449
LEU G 288
 None
 1.06A 1oipA-6ck9G:
undetectable		 1oipA-6ck9G:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 5 ILE A 206
ILE A 138
VAL A 207
ILE A 217
ILE A 182
 None
 1.01A 1oipA-6d46A:
undetectable		 1oipA-6d46A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 ILE L  23
ILE L  13
ILE L 540
LEU L 522
VAL L  28
 None
 0.89A 1oipA-6ehsL:
undetectable		 1oipA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ehs HYDROGENASE-2 LARGE
CHAIN

(Escherichia
coli) 		no annotation 5 LEU L 534
ILE L  23
ILE L 540
LEU L 522
VAL L  28
 None
 0.87A 1oipA-6ehsL:
undetectable		 1oipA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh8 -

(-) 		no annotation 5 LEU A 100
ILE A 122
LEU A  70
ILE A  68
ILE A  40
 None
 0.93A 1oipA-6gh8A:
undetectable		 1oipA-6gh8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b74 GLUTAMATE RACEMASE

(Aquifex
pyrophilus) 		PF01177
(Asp_Glu_race) 		4 SER A 205
SER A 207
VAL A  67
PHE A  90
 None
 1.35A 1oipA-1b74A:
1.0		 1oipA-1b74A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtp DIPHTHERIA TOXIN

(Corynephage
beta) 		PF02763
(Diphtheria_C) 		4 SER A  55
PHE A  17
VAL A 147
PHE A 140
 None
 1.36A 1oipA-1dtpA:
undetectable		 1oipA-1dtpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8t HEMAGGLUTININ-NEURAM
INIDASE

(Avian
avulavirus 1) 		PF00423
(HN) 		4 SER A 237
SER A 239
VAL A 316
PHE A 314
 None
 1.14A 1oipA-1e8tA:
undetectable		 1oipA-1e8tA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Escherichia
coli) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		4 SER A 368
SER A 394
PHE A 254
PHE A 436
 PIN  A 506 ( 3.8A)
None
None
None
 1.42A 1oipA-1ecgA:
undetectable		 1oipA-1ecgA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mgt PROTEIN
(O6-METHYLGUANINE-DN
A METHYLTRANSFERASE)

(Thermococcus
kodakarensis) 		PF01035
(DNA_binding_1)
PF09153
(DUF1938) 		4 SER A  61
PHE A   7
VAL A  18
PHE A  20
 None
 1.05A 1oipA-1mgtA:
undetectable		 1oipA-1mgtA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 SER A 238
SER A 242
PHE A 371
PHE A 152
 SO4  A 593 (-1.9A)
None
I40  A 997 (-4.9A)
None
 1.46A 1oipA-1qonA:
0.4		 1oipA-1qonA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4p SHIGA-LIKE TOXIN
TYPE II A SUBUNIT

(Escherichia
coli) 		PF00161
(RIP) 		4 SER A 134
SER A 138
VAL A 164
PHE A 161
 FMT  A3013 (-2.6A)
None
None
None
 0.95A 1oipA-1r4pA:
undetectable		 1oipA-1r4pA:
19.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r5l PROTEIN
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 SER A 136
SER A 140
PHE A 158
VAL A 182
PHE A 187
 VIV  A 301 (-3.5A)
VIV  A 301 (-3.1A)
VIV  A 301 (-3.9A)
VIV  A 301 (-4.5A)
VIV  A 301 (-3.9A)
 0.28A 1oipA-1r5lA:
43.4		 1oipA-1r5lA:
93.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		4 SER A 137
SER A 138
VAL A  99
PHE A  57
 None
 1.20A 1oipA-1thgA:
1.9		 1oipA-1thgA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 SER A 382
SER A 209
VAL A 349
PHE A 358
 None
 1.08A 1oipA-1xmbA:
undetectable		 1oipA-1xmbA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		4 SER A 100
SER A 103
PHE A 128
VAL A  74
 None
 1.34A 1oipA-1yvpA:
2.9		 1oipA-1yvpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2abq FRUCTOSE 1-PHOSPHATE
KINASE

(Bacillus
halodurans) 		PF00294
(PfkB) 		4 SER A 213
SER A 227
PHE A 157
VAL A 269
 None
 1.23A 1oipA-2abqA:
undetectable		 1oipA-2abqA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN

(Escherichia
coli) 		PF02635
(DrsE) 		4 SER A  18
SER A  19
VAL A   7
PHE A 128
 None
 1.03A 1oipA-2d1pA:
undetectable		 1oipA-2d1pA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j13 POLYSACCHARIDE
DEACETYLASE

(Bacillus
anthracis) 		PF01522
(Polysacc_deac_1) 		4 SER A 106
SER A 104
VAL A 113
PHE A 110
 None
 1.41A 1oipA-2j13A:
undetectable		 1oipA-2j13A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1s INNER MEMBRANE
LIPOPROTEIN YIAD

(Escherichia
coli) 		PF00691
(OmpA) 		4 SER A  93
SER A  96
PHE A  38
VAL A  70
 None
 1.48A 1oipA-2k1sA:
undetectable		 1oipA-2k1sA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpm CYTOKININ
DEHYDROGENASE 1

(Zea mays) 		PF01565
(FAD_binding_4)
PF09265
(Cytokin-bind) 		4 SER A 436
PHE A 281
VAL A 451
PHE A 452
 None
 1.31A 1oipA-2qpmA:
undetectable		 1oipA-2qpmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x77 ADP-RIBOSYLATION
FACTOR

(Leishmania
major) 		PF00025
(Arf) 		4 SER A 163
SER A 161
VAL A  94
PHE A 127
 GDP  A 188 (-4.2A)
None
None
None
 1.48A 1oipA-2x77A:
undetectable		 1oipA-2x77A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z7x TOLL-LIKE RECEPTOR
1, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Homo sapiens) 		PF11921
(DUF3439)
PF13855
(LRR_8) 		4 SER B 122
SER B 147
PHE B 143
VAL B 195
 None
 1.03A 1oipA-2z7xB:
1.4		 1oipA-2z7xB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2k TRNA(ILE)-LYSIDINE
SYNTHASE

(Geobacillus
kaustophilus) 		PF01171
(ATP_bind_3)
PF09179
(TilS)
PF11734
(TilS_C) 		4 SER A  26
SER A  31
PHE A 111
VAL A  70
 None
 1.28A 1oipA-3a2kA:
undetectable		 1oipA-3a2kA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN

(Thermus
thermophilus) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		4 SER A 638
SER A 642
VAL A 585
PHE A 589
 None
 0.86A 1oipA-3aqpA:
undetectable		 1oipA-3aqpA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl5 QUEUOSINE
BIOSYNTHESIS PROTEIN
QUEC

(Bacillus
subtilis) 		PF06508
(QueC) 		4 SER A 103
SER A 106
PHE A 136
PHE A 152
 None
 1.19A 1oipA-3bl5A:
undetectable		 1oipA-3bl5A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clq UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF06545
(DUF1116) 		4 SER A 185
PHE A 278
VAL A 191
PHE A 194
 None
 1.30A 1oipA-3clqA:
undetectable		 1oipA-3clqA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwx PROTEIN CAGD

(Helicobacter
pylori) 		PF16567
(CagD) 		4 SER A 111
SER A 113
VAL A  63
PHE A  60
 None
 1.26A 1oipA-3cwxA:
undetectable		 1oipA-3cwxA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 SER A 154
PHE A 182
VAL A 200
PHE A  77
 None
 1.49A 1oipA-3evzA:
undetectable		 1oipA-3evzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ian CHITINASE

(Lactococcus
lactis) 		PF00704
(Glyco_hydro_18) 		4 SER A 285
PHE A  68
VAL A 341
PHE A 340
 None
EDO  A 364 ( 3.5A)
None
None
 1.47A 1oipA-3ianA:
2.6		 1oipA-3ianA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu1 GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE 1

(Homo sapiens) 		PF01233
(NMT)
PF02799
(NMT_C) 		4 SER A 421
SER A 399
PHE A 461
VAL A 494
 None
 1.41A 1oipA-3iu1A:
undetectable		 1oipA-3iu1A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nlc UNCHARACTERIZED
PROTEIN VP0956

(Vibrio
parahaemolyticus) 		no annotation 4 SER A 368
PHE A 467
VAL A 371
PHE A 333
 None
 1.20A 1oipA-3nlcA:
undetectable		 1oipA-3nlcA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qxl RAS-SPECIFIC GUANINE
NUCLEOTIDE-RELEASING
FACTOR RALGPS1

(Homo sapiens) 		PF00617
(RasGEF) 		4 SER A 146
SER A 150
PHE A  98
VAL A 105
 None
 1.04A 1oipA-3qxlA:
undetectable		 1oipA-3qxlA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r7w GTP-BINDING PROTEIN
GTR1
GTP-BINDING PROTEIN
GTR2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF04670
(Gtr1_RagA)
PF04670
(Gtr1_RagA) 		4 SER B 273
PHE A 213
VAL B 237
PHE B 234
 None
 1.25A 1oipA-3r7wB:
undetectable		 1oipA-3r7wB:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 SER A 235
PHE A 319
VAL A 285
PHE A 277
 None
 1.10A 1oipA-3tqiA:
undetectable		 1oipA-3tqiA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujk PROTEIN PHOSPHATASE
2C 77

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 SER A 232
SER A 234
VAL A 216
PHE A 213
 None
 1.49A 1oipA-3ujkA:
undetectable		 1oipA-3ujkA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vas PUTATIVE ADENOSINE
KINASE

(Schistosoma
mansoni) 		PF00294
(PfkB) 		4 SER A 197
PHE A 192
VAL A 170
PHE A 169
 None
None
None
ADN  A 401 (-3.7A)
 1.32A 1oipA-3vasA:
undetectable		 1oipA-3vasA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3von UBIQUITIN
THIOESTERASE OTUB1

(Homo sapiens) 		PF10275
(Peptidase_C65) 		4 SER A 180
PHE A 130
VAL A 200
PHE A 203
 None
 1.30A 1oipA-3vonA:
undetectable		 1oipA-3vonA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccv HISTIDINE-RICH
GLYCOPROTEIN

(Oryctolagus
cuniculus) 		no annotation 4 SER A 139
PHE A 205
VAL A 178
PHE A 180
 None
 1.17A 1oipA-4ccvA:
undetectable		 1oipA-4ccvA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbh ALCOHOL
DEHYDROGENASE (ZINC)

(Pyrobaculum
aerophilum) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 SER A 203
SER A 207
VAL A 324
PHE A 301
 None
 1.22A 1oipA-4jbhA:
undetectable		 1oipA-4jbhA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgc BILE ACID-COENZYME A
LIGASE

([Clostridium]
scindens) 		PF00501
(AMP-binding) 		4 SER A 206
SER A 209
PHE A  19
PHE A 264
 None
 1.26A 1oipA-4lgcA:
undetectable		 1oipA-4lgcA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk4 VESB PROTEASE

(Vibrio cholerae) 		PF00089
(Trypsin) 		4 SER A 366
PHE A 355
VAL A 335
PHE A 290
 None
 1.09A 1oipA-4lk4A:
undetectable		 1oipA-4lk4A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A  93
SER A  94
VAL A  45
PHE A  42
 None
 1.46A 1oipA-4m7eA:
undetectable		 1oipA-4m7eA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbq POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Coxiella
burnetii) 		PF00013
(KH_1)
PF00575
(S1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 SER A 445
SER A 441
PHE A 381
PHE A 385
 None
SO4  A 701 (-3.7A)
None
None
 1.46A 1oipA-4nbqA:
2.6		 1oipA-4nbqA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nge PRESEQUENCE
PROTEASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		4 SER D 351
SER D 350
VAL D 378
PHE D 389
 None
 1.38A 1oipA-4ngeD:
undetectable		 1oipA-4ngeD:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pev MEMBRANE LIPOPROTEIN
FAMILY PROTEIN

(Aeropyrum
pernix) 		PF02608
(Bmp) 		4 SER A 321
SER A 359
PHE A 288
VAL A 390
 None
 1.45A 1oipA-4pevA:
undetectable		 1oipA-4pevA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6r SPHINGOSINE-1-PHOSPH
ATE LYASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 SER A 482
PHE A 500
VAL A 442
PHE A 443
 None
 1.30A 1oipA-4q6rA:
undetectable		 1oipA-4q6rA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql6 CARBOXY-TERMINAL
PROCESSING PROTEASE

(Chlamydia
trachomatis) 		PF00595
(PDZ)
PF03572
(Peptidase_S41) 		4 SER A 223
SER A 227
PHE A 100
VAL A  34
 None
 1.28A 1oipA-4ql6A:
3.1		 1oipA-4ql6A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		4 SER A 234
PHE A 222
VAL A 172
PHE A 236
 None
 1.45A 1oipA-4wy8A:
2.6		 1oipA-4wy8A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		4 SER A 145
SER A 146
VAL A 132
PHE A 130
 None
 1.36A 1oipA-5cbmA:
undetectable		 1oipA-5cbmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		4 SER A 356
SER A 360
PHE A 294
VAL A 301
 None
 1.04A 1oipA-5cm9A:
undetectable		 1oipA-5cm9A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5b FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF14826
(FACT-Spt16_Nlob) 		4 SER A  37
SER A  49
VAL A 136
PHE A 137
 None
 1.22A 1oipA-5e5bA:
undetectable		 1oipA-5e5bA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ftf TPR DOMAIN PROTEIN

(Bacteroides sp.
3_1_23) 		PF05970
(PIF1) 		4 SER A 267
SER A 268
PHE A  75
PHE A 264
 None
 1.24A 1oipA-5ftfA:
undetectable		 1oipA-5ftfA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxe EUGENOL OXIDASE

(Rhodococcus
jostii) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 SER A  55
PHE A 521
VAL A   9
PHE A  14
 None
 1.21A 1oipA-5fxeA:
undetectable		 1oipA-5fxeA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j3u PROTEIN KINASE A

(Toxoplasma
gondii) 		PF00027
(cNMP_binding) 		4 SER A 386
PHE A 164
VAL A 323
PHE A 324
 None
 1.49A 1oipA-5j3uA:
undetectable		 1oipA-5j3uA:
21.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mue ALPHA-TOCOPHEROL
TRANSFER PROTEIN

(Homo sapiens) 		PF00650
(CRAL_TRIO)
PF03765
(CRAL_TRIO_N) 		5 SER A 136
SER A 140
PHE A 158
VAL A 182
PHE A 187
 VIV  A 302 (-3.5A)
VIV  A 302 (-3.2A)
VIV  A 302 (-3.9A)
VIV  A 302 (-4.4A)
VIV  A 302 (-4.0A)
 0.22A 1oipA-5mueA:
39.1		 1oipA-5mueA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsz LYSOPHOSPHATIDIC
ACID RECEPTOR
6A,ENDOLYSIN,LYSOPHO
SPHATIDIC ACID
RECEPTOR 6A

(Danio rerio;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 SER A 306
PHE A  52
VAL A 301
PHE A 304
 None
 1.40A 1oipA-5xszA:
undetectable		 1oipA-5xszA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zqe -

(-) 		no annotation 4 SER A 158
SER A  60
VAL A 155
PHE A 154
 None
 1.35A 1oipA-5zqeA:
undetectable		 1oipA-5zqeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7y TYROSINE-PROTEIN
KINASE JAK1
SUPPRESSOR OF
CYTOKINE SIGNALING 1

(Homo sapiens;
Gallus gallus) 		no annotation
no annotation 		4 SER A1043
PHE A1058
VAL A1101
PHE B  55
 None
 1.46A 1oipA-6c7yA:
undetectable		 1oipA-6c7yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czp OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE

(Vibrio
vulnificus) 		no annotation 4 SER A  43
SER A  40
VAL A 125
PHE A 124
 None
 1.44A 1oipA-6czpA:
undetectable		 1oipA-6czpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 4 SER A 440
SER A 441
PHE A 489
VAL A 516
 None
 1.41A 1oipA-6etiA:
2.8		 1oipA-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 4 SER A 742
SER A 741
VAL A 731
PHE A 393
 None
 1.23A 1oipA-6fikA:
undetectable		 1oipA-6fikA:
undetectable