SIMILAR PATTERNS OF AMINO ACIDS FOR 1OG5_B_SWFB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hxj BETA-GLUCOSIDASE

(Zea mays) 		PF00232
(Glyco_hydro_1) 		5 ARG A  58
ILE A  59
PHE A 461
THR A 197
PHE A 193
 None
 1.19A 1og5B-1hxjA:
0.0		 1og5B-1hxjA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8t UDP-GALACTOPYRANOSE
MUTASE

(Escherichia
coli) 		PF03275
(GLF)
PF13450
(NAD_binding_8) 		5 ILE A  57
ALA A  55
PHE A 285
PRO A  82
LEU A  93
 FAD  A 450 (-4.1A)
None
None
None
None
 1.18A 1og5B-1i8tA:
undetectable		 1og5B-1i8tA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihb CYCLIN-DEPENDENT
KINASE 6 INHIBITOR

(Homo sapiens) 		PF13637
(Ank_4)
PF13857
(Ank_5) 		5 ILE A  98
ALA A  72
LEU A 109
PRO A 106
LEU A 122
 None
 1.15A 1og5B-1ihbA:
0.0		 1og5B-1ihbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE

(Thermus
thermophilus) 		PF00764
(Arginosuc_synth) 		5 ILE A  57
ALA A  58
THR A  51
LEU A  49
LEU A  17
 None
 1.20A 1og5B-1kh2A:
0.0		 1og5B-1kh2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lxy ARGININE DEIMINASE

(Mycoplasma
arginini) 		PF02274
(Amidinotransf) 		5 ILE A 362
ALA A 396
PHE A 384
THR A 370
LEU A 374
 None
 0.94A 1og5B-1lxyA:
0.0		 1og5B-1lxyA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2v PROTEIN TRANSPORT
PROTEIN SEC24

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 ARG B 672
ILE B 675
ALA B 659
PHE B 723
LEU B 668
 None
 1.22A 1og5B-1m2vB:
0.0		 1og5B-1m2vB:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus) 		PF00067
(p450) 		5 ARG A  97
LEU A 208
THR A 361
LEU A 363
PRO A 364
 HEM  A 500 (-2.6A)
None
None
HEM  A 500 (-4.0A)
None
 1.07A 1og5B-1nr6A:
55.1		 1og5B-1nr6A:
77.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		5 ARG A  99
PHE A 101
LEU A 121
ALA A 102
PHE A 185
 None
 1.18A 1og5B-1olpA:
1.7		 1og5B-1olpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE

(Enterovirus C) 		PF00680
(RdRP_1) 		5 LEU A 420
ALA A 421
PHE A 432
LEU A 447
PRO A 448
 None
 1.06A 1og5B-1rdrA:
0.0		 1og5B-1rdrA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE B 583
LEU B 571
ALA B 572
LEU B 589
PHE B 602
 None
 0.89A 1og5B-1t3qB:
undetectable		 1og5B-1t3qB:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxo YDEN PROTEIN

(Bacillus
subtilis) 		PF06821
(Ser_hydrolase) 		5 ILE A   8
ALA A  69
THR A 113
LEU A  78
PHE A  99
 None
 1.04A 1og5B-1uxoA:
undetectable		 1og5B-1uxoA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vef ACETYLORNITHINE/ACET
YL-LYSINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 ARG A 212
PHE A 240
LEU A 222
PRO A 247
LEU A 104
 None
 1.14A 1og5B-1vefA:
undetectable		 1og5B-1vefA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		5 ILE A 241
ALA A 216
PHE A 124
ASN A 115
LEU A 271
 None
 1.20A 1og5B-1vfnA:
undetectable		 1og5B-1vfnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ILE B  80
PHE B  82
PRO B 117
LEU B 173
PHE B  37
 None
 1.22A 1og5B-1w85B:
undetectable		 1og5B-1w85B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE

(Bos taurus) 		PF00587
(tRNA-synt_2b) 		5 LEU A  59
ALA A  56
LEU A 153
PRO A 154
LEU A 381
 None
 1.22A 1og5B-1wleA:
undetectable		 1og5B-1wleA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 ILE A 164
PHE A 179
THR A 119
LEU A  98
LEU A 112
 None
 1.15A 1og5B-1xtpA:
undetectable		 1og5B-1xtpA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4u CHAPERONE PROTEIN
HTPG

(Escherichia
coli) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 ILE A 120
PHE A 123
ASN A  38
LEU A  94
PHE A 127
 None
 1.05A 1og5B-1y4uA:
undetectable		 1og5B-1y4uA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 PHE A 689
LEU A 688
THR A 698
PRO A 700
LEU A 666
 None
 1.14A 1og5B-2d5lA:
undetectable		 1og5B-2d5lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 PHE A 241
LEU A  91
ALA A  90
LEU A 275
PHE A  68
 None
 1.03A 1og5B-2douA:
undetectable		 1og5B-2douA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dul N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE

(Pyrococcus
horikoshii) 		PF02005
(TRM) 		5 PHE A 134
LEU A  52
THR A  69
PRO A  48
PHE A  65
 None
 1.18A 1og5B-2dulA:
undetectable		 1og5B-2dulA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 ILE A  27
ALA A 389
PHE A 381
LEU A 355
PHE A 228
 None
 1.12A 1og5B-2e0pA:
undetectable		 1og5B-2e0pA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		5 ILE X 108
PHE X 157
THR X 413
LEU X 113
LEU X 387
 None
 1.03A 1og5B-2epkX:
undetectable		 1og5B-2epkX:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC

(Salmonella
enterica) 		PF00291
(PALP) 		5 ILE A 180
LEU A  46
LEU A 287
PRO A 182
LEU A 188
 None
None
None
LLP  A  58 ( 4.6A)
LLP  A  58 ( 4.5A)
 1.23A 1og5B-2gn1A:
undetectable		 1og5B-2gn1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 ILE A 462
PHE A 532
ALA A 428
LEU A 564
LEU A 444
 None
 1.19A 1og5B-2hauA:
undetectable		 1og5B-2hauA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hun 336AA LONG
HYPOTHETICAL
DTDP-GLUCOSE
4,6-DEHYDRATASE

(Pyrococcus
horikoshii) 		PF16363
(GDP_Man_Dehyd) 		5 ILE A 242
LEU A 229
ALA A 226
LEU A  82
PHE A  19
 None
None
None
NAD  A 801 (-4.3A)
None
 1.18A 1og5B-2hunA:
undetectable		 1og5B-2hunA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		5 ILE A 561
PHE A 546
ALA A 547
PHE A 553
LEU A 543
 None
 1.21A 1og5B-2j6hA:
undetectable		 1og5B-2j6hA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1) 		5 ILE B  72
LEU B  43
PHE B  74
LEU B  87
LEU B  92
 None
 1.20A 1og5B-2km8B:
undetectable		 1og5B-2km8B:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 ILE A 465
LEU A 378
ALA A 379
LEU A 521
LEU A 459
 None
 1.21A 1og5B-2qveA:
undetectable		 1og5B-2qveA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgz HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 ILE A  62
PHE A  67
LEU A  69
LEU A 177
PHE A 116
 None
 1.09A 1og5B-2rgzA:
undetectable		 1og5B-2rgzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5y RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE MU

(Homo sapiens) 		PF00041
(fn3)
PF00047
(ig)
PF00629
(MAM) 		5 ILE A 171
PHE A 168
LEU A 169
LEU A 198
PHE A 221
 None
 0.96A 1og5B-2v5yA:
undetectable		 1og5B-2v5yA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 217
ALA A 185
ASN A 166
LEU A 214
PRO A 215
 None
None
None
EDO  A1510 (-4.7A)
EDO  A1510 (-4.1A)
 0.87A 1og5B-2w40A:
undetectable		 1og5B-2w40A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ILE A 459
PHE A 458
ALA A 194
PHE A 447
LEU A 682
 None
 1.15A 1og5B-2xf2A:
undetectable		 1og5B-2xf2A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN

(Bacillus
thuringiensis) 		PF00091
(Tubulin) 		5 PHE A 280
LEU A 281
PHE A 315
PRO A 382
LEU A 183
 None
 1.13A 1og5B-2xkaA:
undetectable		 1og5B-2xkaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Thermotoga
maritima) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		5 ILE B 396
PHE B 397
ALA B 393
LEU B 371
PHE B 376
 None
 0.89A 1og5B-3al0B:
undetectable		 1og5B-3al0B:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5d PUTATIVE GLYOXALASE
I

(Listeria
monocytogenes) 		PF00903
(Glyoxalase) 		5 PHE A  24
LEU A  44
ALA A  26
LEU A  91
PHE A  19
 None
 1.12A 1og5B-3e5dA:
undetectable		 1og5B-3e5dA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		5 ARG A 333
ILE A 471
LEU A 352
ALA A 470
LEU A 197
 FMN  A 700 (-3.0A)
None
None
None
None
 1.21A 1og5B-3eo7A:
undetectable		 1og5B-3eo7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdh SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 ARG A 111
ILE A 114
LEU A  46
ALA A 133
LEU A 107
 None
 1.13A 1og5B-3fdhA:
undetectable		 1og5B-3fdhA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		5 ILE A 286
THR A   3
LEU A 296
LEU A 324
PHE A   6
 None
 1.00A 1og5B-3gr8A:
undetectable		 1og5B-3gr8A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ILE A 334
ALA A 432
LEU A 346
LEU A 354
PHE A 450
 None
 1.07A 1og5B-3h8fA:
undetectable		 1og5B-3h8fA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h95 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		PF00293
(NUDIX) 		5 PHE A 151
LEU A 229
ALA A 149
LEU A 270
PHE A 279
 None
 0.89A 1og5B-3h95A:
undetectable		 1og5B-3h95A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hko CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 2
CALMODULIN-LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ILE A 176
PHE A 222
ALA A 244
LEU A  97
PRO A 178
 None
 1.17A 1og5B-3hkoA:
undetectable		 1og5B-3hkoA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iqx TAIL-ANCHORED
PROTEIN TARGETING
FACTOR GET3

(Chaetomium
thermophilum) 		PF02374
(ArsA_ATPase) 		5 ILE A  30
PHE A  31
LEU A 233
LEU A 142
PHE A 228
 None
 1.08A 1og5B-3iqxA:
undetectable		 1og5B-3iqxA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jbz SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom) 		5 ILE A1603
PHE A1557
LEU A1559
ALA A1560
LEU A1642
 None
 0.99A 1og5B-3jbzA:
undetectable		 1og5B-3jbzA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 ILE A1788
LEU A1759
ALA A1806
PHE A1786
LEU A1734
 None
 1.02A 1og5B-3kg6A:
undetectable		 1og5B-3kg6A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbg PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT)
PF12134
(PRP8_domainIV) 		5 ILE A2207
PHE A2206
LEU A2226
THR A2276
LEU A2280
 None
 1.07A 1og5B-3sbgA:
undetectable		 1og5B-3sbgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sll PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacteroides
abscessus) 		PF00378
(ECH_1) 		5 ARG A 127
ILE A 109
ALA A 113
LEU A 122
LEU A  98
 GOL  A 270 (-3.0A)
None
None
GOL  A 270 (-4.6A)
None
 0.84A 1og5B-3sllA:
undetectable		 1og5B-3sllA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 ILE A 142
PHE A   7
LEU A   8
ALA A   9
PHE A 138
 None
 1.10A 1og5B-3t5tA:
1.2		 1og5B-3t5tA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tha TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Campylobacter
jejuni) 		PF00290
(Trp_syntA) 		5 ILE A  39
ALA A  15
THR A  26
LEU A  31
LEU A 236
 None
 1.18A 1og5B-3thaA:
undetectable		 1og5B-3thaA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vfi THIOREDOXIN

(Silicibacter
phage DSS3phi2) 		PF00085
(Thioredoxin) 		5 ILE A  22
PHE A  79
THR A  64
LEU A  68
PHE A  10
 None
 1.08A 1og5B-3vfiA:
undetectable		 1og5B-3vfiA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ac0 TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0

(Escherichia
coli) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ILE A  10
LEU A  16
ALA A  13
THR A  40
LEU A   4
 None
 1.12A 1og5B-4ac0A:
undetectable		 1og5B-4ac0A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8

(Saccharomyces
cerevisiae) 		PF08084
(PROCT) 		5 ILE C2207
PHE C2206
LEU C2226
THR C2276
LEU C2280
 None
 1.10A 1og5B-4bgdC:
undetectable		 1og5B-4bgdC:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw4 BETA-KETOACYL
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ILE A 389
PHE A 388
ALA A 540
THR A 385
LEU A 288
 None
 1.18A 1og5B-4cw4A:
undetectable		 1og5B-4cw4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ARG A 275
ALA A 279
THR A 224
LEU A 227
PHE A 193
 None
 1.17A 1og5B-4iv5A:
undetectable		 1og5B-4iv5A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyo CYSTATHIONINE
GAMMA-LYASE-LIKE
PROTEIN, LYS201A
MODIFIED

(Xanthomonas
oryzae) 		PF01053
(Cys_Met_Meta_PP) 		5 ILE B 222
LEU B 203
ALA B 223
PHE B  85
THR B 115
 None
 1.22A 1og5B-4iyoB:
undetectable		 1og5B-4iyoB:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01699
(Na_Ca_ex) 		5 ILE A 177
LEU A  67
ALA A  68
THR A 388
LEU A 392
 None
 1.15A 1og5B-4kppA:
0.7		 1og5B-4kppA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lna PURINE NUCLEOSIDE
PHOSPHORYLASE

(Spirosoma
linguale) 		PF01048
(PNP_UDP_1) 		5 ILE A 232
ALA A 207
PHE A 119
ASN A 110
LEU A 260
 None
 1.02A 1og5B-4lnaA:
undetectable		 1og5B-4lnaA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Toxoplasma
gondii) 		PF00215
(OMPdecase) 		5 ILE A 109
PHE A  25
ALA A 135
LEU A 282
PHE A 161
 None
 1.21A 1og5B-4mjzA:
undetectable		 1og5B-4mjzA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nho PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX23

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 503
LEU A 480
ALA A 481
LEU A 529
PHE A 559
 None
None
None
None
SO4  A 902 ( 4.9A)
 1.05A 1og5B-4nhoA:
undetectable		 1og5B-4nhoA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4onu ACETYLTRANSFERASE
PAT

(Mycolicibacterium
smegmatis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ILE A 320
LEU A 256
ALA A 255
PHE A 312
THR A 210
 None
 1.22A 1og5B-4onuA:
undetectable		 1og5B-4onuA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p81 ANCESTRAL PYRR
PROTEIN (ORANGE)

(synthetic
construct) 		PF00156
(Pribosyltran) 		5 ILE A  45
ALA A  48
THR A 113
LEU A  68
LEU A  72
 None
None
SO4  A 201 (-3.6A)
None
None
 1.16A 1og5B-4p81A:
undetectable		 1og5B-4p81A:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rep GAMMA-CAROTENE
DESATURASE

(Nonlabens
dokdonensis) 		PF01593
(Amino_oxidase) 		5 ILE A  84
PHE A  86
ALA A  98
THR A  58
LEU A  56
 None
None
None
None
FAD  A 501 (-4.7A)
 1.21A 1og5B-4repA:
undetectable		 1og5B-4repA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps CHROMOSOMAL
REPLICATION
INITIATOR PROTEIN
DNAA

(Bacillus
subtilis) 		PF11638
(DnaA_N) 		5 ILE B   4
ALA B  33
ASN B   9
THR B  65
LEU B  69
 None
 1.09A 1og5B-4tpsB:
undetectable		 1og5B-4tpsB:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2

(Vibrio cholerae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		6 ARG A  46
ILE A  47
LEU A 143
LEU A  15
PRO A  16
LEU A 338
 None
 1.24A 1og5B-4x0oA:
undetectable		 1og5B-4x0oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xqk LLABIII

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII)
PF13156
(Mrr_cat_2) 		5 ILE A 559
ALA A 492
ASN A 562
LEU A 575
LEU A 544
 None
 1.19A 1og5B-4xqkA:
1.3		 1og5B-4xqkA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4znj PHAGE TERMINASE
LARGE SUBUNIT

(Thermus virus
P74-26) 		PF03237
(Terminase_6) 		5 ARG A  32
ILE A 176
PHE A 189
THR A 166
LEU A 143
 None
 0.95A 1og5B-4znjA:
undetectable		 1og5B-4znjA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ILE A  82
LEU A  94
PHE A  55
LEU A 239
PHE A  33
 None
 1.19A 1og5B-4zohA:
undetectable		 1og5B-4zohA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		5 ILE D 107
PHE D 156
THR D 412
LEU D 112
LEU D 386
 None
 1.02A 1og5B-5a6bD:
undetectable		 1og5B-5a6bD:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cl2 SPORULATION-CONTROL
PROTEIN SPO0M

(Bacillus
subtilis) 		PF07070
(Spo0M) 		5 ARG A 167
PHE A 171
ALA A 162
PHE A 165
LEU A 196
 None
 1.21A 1og5B-5cl2A:
undetectable		 1og5B-5cl2A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 ILE A 107
PHE A 110
THR A 310
LEU A 306
PHE A  61
 None
 1.17A 1og5B-5co8A:
undetectable		 1og5B-5co8A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwq DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 5 ILE A 100
LEU A  40
ALA A  77
LEU A  93
LEU A 152
 None
 1.13A 1og5B-5cwqA:
undetectable		 1og5B-5cwqA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlj CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Escherichia
coli) 		no annotation 5 PHE D 215
LEU D 213
ALA D 203
LEU D  99
LEU D 272
 None
 1.19A 1og5B-5dljD:
undetectable		 1og5B-5dljD:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erg TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61

(Saccharomyces
cerevisiae) 		PF08704
(GCD14) 		5 ILE B 164
PHE B 138
PHE B 152
LEU B 135
LEU B 195
 None
 1.07A 1og5B-5ergB:
undetectable		 1og5B-5ergB:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ev7 CONSERVED DOMAIN
PROTEIN

(Bacillus
anthracis) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		5 ILE A 401
PHE A 404
ALA A 411
LEU A 353
PHE A 388
 None
 1.20A 1og5B-5ev7A:
undetectable		 1og5B-5ev7A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol) 		5 PHE C 542
LEU C 563
ALA C 749
LEU C 647
PHE C 622
 None
 1.16A 1og5B-5exrC:
undetectable		 1og5B-5exrC:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f17 NON-STRUCTURAL
PROTEIN 11

(Equine
arteritis virus) 		no annotation 5 LEU A 159
ALA A 158
PHE A 105
LEU A 148
PRO A 149
 None
 1.13A 1og5B-5f17A:
undetectable		 1og5B-5f17A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE A 298
LEU A 269
ALA A 270
LEU A 324
PHE A 354
 None
 1.12A 1og5B-5h1yA:
undetectable		 1og5B-5h1yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1y PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00270
(DEAD) 		5 ILE A 310
LEU A 296
ALA A 295
PRO A 258
LEU A 335
 None
 1.18A 1og5B-5h1yA:
undetectable		 1og5B-5h1yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqj UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		no annotation 5 ILE A  30
LEU A   9
ALA A   8
THR A  25
PRO A  28
 None
None
None
CL  A 201 (-3.5A)
None
 1.19A 1og5B-5iqjA:
undetectable		 1og5B-5iqjA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh5 ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		5 ILE A 109
ALA A 129
THR A 115
LEU A 145
PHE A 123
 None
 1.20A 1og5B-5kh5A:
undetectable		 1og5B-5kh5A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		5 ARG A 113
ILE A  85
LEU A  93
PHE A 110
LEU A 304
 None
None
None
EDO  A1001 ( 4.7A)
None
 1.16A 1og5B-5lqdA:
undetectable		 1og5B-5lqdA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		5 ILE A 185
PHE A 188
LEU A 187
ALA A 186
THR A 248
 None
 1.21A 1og5B-5mrwA:
1.1		 1og5B-5mrwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		5 ILE A 185
PHE A 188
LEU A 187
THR A 248
LEU A 250
 None
 1.22A 1og5B-5mrwA:
1.1		 1og5B-5mrwA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o8r L-LYSINE
6-MONOOXYGENASE
INVOLVED IN
DESFERRIOXAMINE
BIOSYNTHESIS

(Erwinia
amylovora) 		no annotation 5 ILE A   9
PHE A   8
ALA A 149
LEU A 154
LEU A  20
 None
 1.19A 1og5B-5o8rA:
undetectable		 1og5B-5o8rA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8u LIPOATE-PROTEIN
LIGASE 1

(Plasmodium
falciparum) 		PF03099
(BPL_LplA_LipB)
PF10437
(Lip_prot_lig_C) 		5 ILE A  65
PHE A 120
LEU A 174
LEU A 230
PHE A 118
 None
 1.09A 1og5B-5t8uA:
undetectable		 1og5B-5t8uA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SECURIN
SEPARIN

(Saccharomyces
cerevisiae) 		PF03568
(Peptidase_C50)
PF04856
(Securin) 		5 ILE A 173
LEU A 119
ALA A 128
LEU A 166
LEU B 371
 None
 1.13A 1og5B-5u1sA:
undetectable		 1og5B-5u1sA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 ILE A 241
ALA A 216
PHE A 124
ASN A 115
LEU A 271
 None
None
None
PO4  A 301 (-4.9A)
None
 1.16A 1og5B-5ugfA:
undetectable		 1og5B-5ugfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 ILE A 241
PHE A 124
ASN A 115
LEU A 271
PHE A 238
 None
None
PO4  A 301 (-4.9A)
None
None
 1.05A 1og5B-5ugfA:
undetectable		 1og5B-5ugfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 5 ARG B 134
ILE B 116
ALA B 120
LEU B 129
PHE B 102
 None
 1.22A 1og5B-5wybB:
undetectable		 1og5B-5wybB:
11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 7 ARG A  97
ASN A 218
THR A 364
LEU A 366
PRO A 367
LEU A 388
PHE A 476
 HEM  A 504 (-2.5A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
 0.81A 1og5B-5xxiA:
58.9		 1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 7 ARG A  97
ILE A  99
PHE A 100
ALA A 103
ASN A 218
LEU A 366
PRO A 367
 HEM  A 504 (-2.5A)
None
LSN  A 503 (-4.1A)
LSN  A 503 ( 4.0A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
 0.84A 1og5B-5xxiA:
58.9		 1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 8 ARG A  97
ILE A  99
PHE A 100
ASN A 218
THR A 364
LEU A 366
PRO A 367
LEU A 388
 HEM  A 504 (-2.5A)
None
LSN  A 503 (-4.1A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
 0.91A 1og5B-5xxiA:
58.9		 1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 5 ILE A  99
PHE A 100
LEU A 102
ALA A 103
ASN A 218
 None
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 503 ( 4.0A)
LSN  A 503 (-3.1A)
 1.03A 1og5B-5xxiA:
58.9		 1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 6 ILE A  99
PHE A 100
LEU A 102
ASN A 218
THR A 364
LEU A 388
 None
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
 1.12A 1og5B-5xxiA:
58.9		 1og5B-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 5 LEU A 102
ASN A 218
THR A 364
LEU A 388
PHE A 476
 LSN  A 503 (-3.5A)
LSN  A 503 (-3.1A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
 0.94A 1og5B-5xxiA:
58.9		 1og5B-5xxiA:
96.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ys9 ACYL-COENZYME A
OXIDASE 3

(Yarrowia
lipolytica) 		no annotation 5 ILE A 189
LEU A 218
ALA A 178
PHE A 229
THR A 184
 None
 1.21A 1og5B-5ys9A:
undetectable		 1og5B-5ys9A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zai -

(-) 		no annotation 5 ARG A 121
ILE A 103
LEU A 108
ALA A 107
LEU A 116
 None
None
COA  A 301 (-4.7A)
None
None
 1.22A 1og5B-5zaiA:
undetectable		 1og5B-5zaiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zh6 -

(-) 		no annotation 5 PHE A  68
ALA A  72
LEU A  63
LEU A  48
PHE A  64
 None
 1.18A 1og5B-5zh6A:
undetectable		 1og5B-5zh6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cf8 LYTIC
TRANSGLYCOSYLASE

(Campylobacter
jejuni) 		no annotation 5 ILE A 264
LEU A 236
ALA A 237
PHE A 241
LEU A 489
 None
 1.11A 1og5B-6cf8A:
undetectable		 1og5B-6cf8A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dk2 -

(-) 		no annotation 6 ILE A 127
PHE A 128
LEU A 125
ALA A 124
PHE A 182
LEU A 405
 None
 1.50A 1og5B-6dk2A:
1.0		 1og5B-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffh METABOTROPIC
GLUTAMATE RECEPTOR
5,ENDOLYSIN

(Escherichia
virus T4;
Homo sapiens) 		no annotation 5 ILE A1791
PHE A1788
LEU A1786
ALA A1787
LEU A1808
 None
D7W  A4006 (-3.1A)
OLA  A4007 ( 4.3A)
OLA  A4007 ( 4.6A)
None
 1.22A 1og5B-6ffhA:
0.9		 1og5B-6ffhA:
9.83