SIMILAR PATTERNS OF AMINO ACIDS FOR 1OG5_A_SWFA502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR


(Desmodus
rotundus)
PF00089
(Trypsin)
5 LEU A 199
LEU A 162
LEU A 128
PRO A 124
LEU A 235
None
1.11A 1og5A-1a5iA:
undetectable
1og5A-1a5iA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aw9 GLUTATHIONE
S-TRANSFERASE III


(Zea mays)
PF00043
(GST_C)
PF02798
(GST_N)
5 LEU A 157
ALA A 158
THR A  84
LEU A  87
PRO A  88
None
1.24A 1og5A-1aw9A:
undetectable
1og5A-1aw9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB


(Thermus
thermophilus)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB)
5 PHE A 394
LEU A 396
LEU A 332
LEU A 378
PHE A  31
None
BOG  A9998 ( 4.5A)
None
None
None
1.22A 1og5A-1c4oA:
0.0
1og5A-1c4oA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE


(Bacillus
subtilis)
PF02110
(HK)
5 PHE A 207
ALA A 218
LEU A 183
LEU A 200
LEU A  39
None
1.17A 1og5A-1ekqA:
0.0
1og5A-1ekqA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i41 CYSTATHIONINE
GAMMA-SYNTHASE


(Nicotiana
tabacum)
PF01053
(Cys_Met_Meta_PP)
5 LEU A 147
ALA A 148
LEU A 291
LEU A 133
LEU A 256
None
1.14A 1og5A-1i41A:
undetectable
1og5A-1i41A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kph CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 1


(Mycobacterium
tuberculosis)
PF02353
(CMAS)
5 PHE A 151
LEU A 153
ALA A 154
THR A 168
PHE A 139
None
1.04A 1og5A-1kphA:
0.2
1og5A-1kphA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mew INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE


(Tritrichomonas
suis)
PF00478
(IMPDH)
PF00571
(CBS)
5 LEU A 369
ALA A 370
LEU A  54
PRO A  53
LEU A  33
None
1.16A 1og5A-1mewA:
undetectable
1og5A-1mewA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mtp SERINE PROTEINASE
INHIBITOR (SERPIN),
CHAIN A


(Thermobifida
fusca)
PF00079
(Serpin)
5 LEU A 286
ALA A  50
LEU A 279
PRO A  66
LEU A  70
None
1.23A 1og5A-1mtpA:
undetectable
1og5A-1mtpA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS


(Thermus
aquaticus)
PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III)
5 ARG A 354
LEU A 375
LEU A 517
THR A 281
LEU A 326
None
1.05A 1og5A-1nneA:
0.0
1og5A-1nneA:
20.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nr6 CYTOCHROME P450 2C5

(Oryctolagus
cuniculus)
PF00067
(p450)
6 ARG A  97
LEU A 208
PHE A 114
THR A 361
LEU A 363
PRO A 364
HEM  A 500 (-2.6A)
None
DIF  A 501 (-4.5A)
None
HEM  A 500 (-4.0A)
None
1.14A 1og5A-1nr6A:
55.1
1og5A-1nr6A:
77.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense)
PF00882
(Zn_dep_PLPC)
PF01477
(PLAT)
5 ARG A  99
PHE A 101
LEU A 121
ALA A 102
PHE A 185
None
1.23A 1og5A-1olpA:
undetectable
1og5A-1olpA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pui PROBABLE GTP-BINDING
PROTEIN ENGB


(Escherichia
coli)
PF01926
(MMR_HSR1)
5 PHE A  31
LEU A  79
ALA A  32
LEU A 103
LEU A 193
None
1.05A 1og5A-1puiA:
undetectable
1og5A-1puiA:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdr POLIOVIRUS 3D
POLYMERASE


(Enterovirus C)
PF00680
(RdRP_1)
5 LEU A 420
ALA A 421
PHE A 432
LEU A 447
PRO A 448
None
1.04A 1og5A-1rdrA:
undetectable
1og5A-1rdrA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugj RIKEN CDNA
2310057J16 PROTEIN


(Mus musculus)
PF08683
(CAMSAP_CKK)
5 ALA A  26
THR A  72
LEU A  57
LEU A  83
PHE A  56
None
1.25A 1og5A-1ugjA:
undetectable
1og5A-1ugjA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vfn PURINE-NUCLEOSIDE
PHOSPHORYLASE


(Bos taurus)
PF01048
(PNP_UDP_1)
5 ALA A 216
PHE A 124
ASN A 115
LEU A 271
PHE A 238
None
1.10A 1og5A-1vfnA:
undetectable
1og5A-1vfnA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3f HEMOLYTIC LECTIN
FROM LAETIPORUS
SULPHUREUS


(Laetiporus
sulphureus)
PF03318
(ETX_MTX2)
5 PHE A 146
LEU A 147
LEU A  11
PRO A   7
LEU A  50
None
1.21A 1og5A-1w3fA:
undetectable
1og5A-1w3fA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN


(Bacillus
subtilis)
PF02113
(Peptidase_S13)
5 LEU A 381
ALA A 410
LEU A 365
THR A 427
LEU A 459
None
1.14A 1og5A-1w5dA:
undetectable
1og5A-1w5dA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wle SERYL-TRNA
SYNTHETASE


(Bos taurus)
PF00587
(tRNA-synt_2b)
5 LEU A  59
ALA A  56
LEU A 153
PRO A 154
LEU A 381
None
1.22A 1og5A-1wleA:
undetectable
1og5A-1wleA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B)
PF00680
(RdRP_1)
5 LEU A 419
ALA A 420
PHE A 431
LEU A 446
PRO A 447
None
1.20A 1og5A-1xr5A:
undetectable
1og5A-1xr5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcw AROMATIC
PRENYLTRANSFERASE


(Streptomyces
sp. CL190)
PF11468
(PTase_Orf2)
5 ALA A 122
PHE A 124
LEU A  94
THR A 218
LEU A 174
None
1.20A 1og5A-1zcwA:
undetectable
1og5A-1zcwA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA


(Homo sapiens)
PF00069
(Pkinase)
PF00433
(Pkinase_C)
5 LEU A 341
ALA A 346
LEU A 331
LEU A 430
LEU A 488
None
1.16A 1og5A-1zrzA:
undetectable
1og5A-1zrzA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE

(Musca domestica)
PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes)
5 LEU A 557
ALA A 558
PRO A 437
LEU A 440
PHE A 434
None
1.23A 1og5A-2bw3A:
undetectable
1og5A-2bw3A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE


(Porphyromonas
gingivalis)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 PHE A 689
LEU A 688
THR A 698
PRO A 700
LEU A 666
None
1.12A 1og5A-2d5lA:
undetectable
1og5A-2d5lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli)
PF03602
(Cons_hypoth95)
5 PHE A 125
LEU A  57
PHE A  60
LEU A 142
LEU A  43
None
1.02A 1og5A-2fpoA:
undetectable
1og5A-2fpoA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3q PROTEIN YBL047C

(Saccharomyces
cerevisiae)
PF00627
(UBA)
5 PHE A1376
LEU A1363
PHE A1354
LEU A1370
LEU A1378
None
1.23A 1og5A-2g3qA:
undetectable
1og5A-2g3qA:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn1 THREONINE
DEHYDRATASE
CATABOLIC


(Salmonella
enterica)
PF00291
(PALP)
5 LEU A  46
LEU A 273
LEU A 287
PRO A 182
LEU A 188
None
None
None
LLP  A  58 ( 4.6A)
LLP  A  58 ( 4.5A)
1.23A 1og5A-2gn1A:
undetectable
1og5A-2gn1A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 PHE A  46
LEU A  48
ALA A  49
LEU A 101
LEU A  78
None
1.12A 1og5A-2hnlA:
undetectable
1og5A-2hnlA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou PERTACTIN
EXTRACELLULAR DOMAIN


(Bordetella
bronchiseptica)
PF03212
(Pertactin)
5 ARG G 484
PHE G 483
LEU G 526
LEU G 539
LEU G 452
None
1.23A 1og5A-2iouG:
undetectable
1og5A-2iouG:
20.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nnj CYTOCHROME P450 2C8

(Homo sapiens)
PF00067
(p450)
5 ARG A  97
LEU A 208
ASN A 217
THR A 364
PRO A 367
HEM  A 500 (-2.6A)
225  A 501 ( 4.3A)
None
None
225  A 501 ( 4.7A)
0.92A 1og5A-2nnjA:
55.0
1og5A-2nnjA:
78.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE


(Infectious
bursal disease
virus)
PF04197
(Birna_RdRp)
5 LEU A  97
LEU A  79
LEU A 346
PRO A 343
LEU A 313
None
1.11A 1og5A-2pggA:
undetectable
1og5A-2pggA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyw UNCHARACTERIZED
PROTEIN


(Arabidopsis
thaliana)
PF01636
(APH)
5 PHE A 310
LEU A 309
THR A 150
LEU A 317
LEU A 151
None
1.21A 1og5A-2pywA:
undetectable
1og5A-2pywA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE


(Bacillus
halodurans)
PF01715
(IPPT)
5 LEU A  80
ALA A  81
LEU A  62
THR A 101
LEU A 103
None
1.19A 1og5A-2qgnA:
undetectable
1og5A-2qgnA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9y ALPHA-2-ANTIPLASMIN

(Mus musculus)
PF00079
(Serpin)
5 LEU A 338
ALA A  97
LEU A 117
PRO A 118
LEU A 158
None
1.25A 1og5A-2r9yA:
undetectable
1og5A-2r9yA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xka FTSZ/TUBULIN-RELATED
PROTEIN


(Bacillus
thuringiensis)
PF00091
(Tubulin)
5 LEU A  56
PHE A  79
LEU A 115
LEU A 148
LEU A 135
None
1.22A 1og5A-2xkaA:
undetectable
1og5A-2xkaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME


(Homo sapiens)
PF01401
(Peptidase_M2)
5 LEU A 603
LEU A 247
ASN A 607
LEU A 255
LEU A 266
None
1.16A 1og5A-2xy9A:
undetectable
1og5A-2xy9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvp MUTT/NUDIX FAMILY
PROTEIN


(Thermus
thermophilus)
PF00293
(NUDIX)
5 LEU A 144
LEU A  70
LEU A  47
PRO A  48
LEU A  91
None
1.03A 1og5A-2yvpA:
undetectable
1og5A-2yvpA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywa HYPOTHETICAL PROTEIN
TTHA0048


(Thermus
thermophilus)
PF08780
(NTase_sub_bind)
5 LEU A 105
ALA A 104
PHE A  74
THR A  85
LEU A  81
None
1.18A 1og5A-2ywaA:
undetectable
1og5A-2ywaA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zyj ALPHA-AMINODIPATE
AMINOTRANSFERASE


(Thermus
thermophilus)
PF00155
(Aminotran_1_2)
5 PHE A 341
LEU A 367
LEU A 369
THR A  29
LEU A  28
None
1.11A 1og5A-2zyjA:
undetectable
1og5A-2zyjA:
20.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e4e CYTOCHROME P450 2E1

(Homo sapiens)
PF00067
(p450)
5 ARG A 100
PHE A 116
LEU A 210
LEU A 368
PRO A 369
HEM  A 500 (-2.4A)
None
None
HEM  A 500 (-3.6A)
None
0.71A 1og5A-3e4eA:
51.4
1og5A-3e4eA:
59.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5d PUTATIVE GLYOXALASE
I


(Listeria
monocytogenes)
PF00903
(Glyoxalase)
5 PHE A  24
LEU A  44
ALA A  26
LEU A  91
PHE A  19
None
1.11A 1og5A-3e5dA:
undetectable
1og5A-3e5dA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE


(Trichormus
variabilis)
PF00881
(Nitroreductase)
5 PHE A 355
LEU A 352
ALA A 351
LEU A 475
LEU A 326
None
1.21A 1og5A-3eo7A:
undetectable
1og5A-3eo7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0i EPOXIDE HYDROLASE

(Aspergillus
niger)
PF06441
(EHN)
5 PHE A 164
LEU A 200
LEU A 149
PRO A 150
LEU A  94
None
1.23A 1og5A-3g0iA:
undetectable
1og5A-3g0iA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1


(Schizosaccharomyces
pombe)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 PHE A  93
LEU A 302
LEU A 211
PRO A 210
LEU A 208
None
1.13A 1og5A-3h0gA:
undetectable
1og5A-3h0gA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0u PUTATIVE ENOYL-COA
HYDRATASE


(Streptomyces
avermitilis)
PF00378
(ECH_1)
5 ARG A 132
PHE A 125
ALA A 118
LEU A 127
LEU A 103
None
1.20A 1og5A-3h0uA:
undetectable
1og5A-3h0uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h95 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6


(Homo sapiens)
PF00293
(NUDIX)
5 PHE A 151
LEU A 229
ALA A 149
LEU A 270
PHE A 279
None
0.95A 1og5A-3h95A:
undetectable
1og5A-3h95A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'


(Sulfolobus
solfataricus)
PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
5 ALA A 472
LEU A 418
THR A 348
PRO A 350
PHE A 320
None
1.09A 1og5A-3hkzA:
undetectable
1og5A-3hkzA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jc5 DNA REPLICATION
COMPLEX GINS PROTEIN
PSF3


(Saccharomyces
cerevisiae)
PF05916
(Sld5)
5 PHE C  80
LEU C  75
THR C  14
LEU C 107
PHE C  16
None
1.16A 1og5A-3jc5C:
2.2
1og5A-3jc5C:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzw CYTOSOL
AMINOPEPTIDASE


(Staphylococcus
aureus)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 PHE A 444
ALA A 441
LEU A 348
LEU A 225
PHE A 448
None
1.24A 1og5A-3kzwA:
undetectable
1og5A-3kzwA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi6 ALPHA-GALACTOSIDASE

(Lactobacillus
brevis)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
5 PHE A  90
LEU A 180
ALA A 179
PHE A 291
LEU A 103
None
1.24A 1og5A-3mi6A:
undetectable
1og5A-3mi6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mq2 16S RRNA
METHYLTRANSFERASE


(Streptoalloteichus
tenebrarius)
PF02390
(Methyltransf_4)
5 ARG A 167
ALA A 160
LEU A 207
LEU A 113
LEU A 120
None
1.25A 1og5A-3mq2A:
undetectable
1og5A-3mq2A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
5 ARG A 200
LEU A 191
PHE A   5
LEU A 139
LEU A 167
None
1.12A 1og5A-3nyqA:
undetectable
1og5A-3nyqA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae)
PF09349
(OHCU_decarbox)
6 PHE A   7
ASN A   8
THR A  47
LEU A  45
LEU A  32
PHE A  38
None
1.40A 1og5A-3o7jA:
undetectable
1og5A-3o7jA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p6l SUGAR PHOSPHATE
ISOMERASE/EPIMERASE


(Parabacteroides
distasonis)
PF01261
(AP_endonuc_2)
5 LEU A  93
ALA A  94
THR A 104
LEU A 127
PHE A  78
None
1.17A 1og5A-3p6lA:
undetectable
1og5A-3p6lA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjp TRANSCRIPTION
ELONGATION FACTOR
SPT6


([Candida]
glabrata)
PF14633
(SH2_2)
5 PHE A1416
LEU A1418
LEU A1394
THR A1350
PHE A1392
None
1.20A 1og5A-3pjpA:
undetectable
1og5A-3pjpA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc1 OCTAPRENYL
PYROPHOSPHATE
SYNTHASE


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
5 ARG A  39
LEU A  46
LEU A 295
LEU A  38
LEU A   6
None
1.20A 1og5A-3tc1A:
undetectable
1og5A-3tc1A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE


(Caldanaerobius
polysaccharolyticus)
PF00150
(Cellulase)
5 PHE A  30
LEU A  28
ALA A  27
LEU A 322
PHE A  36
None
1.22A 1og5A-3w0kA:
undetectable
1og5A-3w0kA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wec CYTOCHROME P450

(Rhodococcus
erythropolis)
PF00067
(p450)
5 LEU A 399
ALA A 300
LEU A 186
ASN A 260
LEU A 371
AUI  A 502 (-4.4A)
AUI  A 502 ( 3.7A)
None
None
None
1.25A 1og5A-3wecA:
28.5
1og5A-3wecA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N)
5 ARG A 127
LEU A 114
ALA A 113
LEU A 122
LEU A  95
None
COA  A1730 ( 4.4A)
None
None
None
1.24A 1og5A-4b3iA:
undetectable
1og5A-4b3iA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4btg MAJOR INNER PROTEIN
P1


(Pseudomonas
virus phi6)
no annotation 5 PHE A 291
LEU A 290
PHE A 484
LEU A 186
LEU A 516
None
1.23A 1og5A-4btgA:
undetectable
1og5A-4btgA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dnh UNCHARACTERIZED
PROTEIN


(Sinorhizobium
meliloti)
PF06187
(DUF993)
5 ALA A  42
PHE A  68
LEU A  77
LEU A 115
PHE A  39
None
1.23A 1og5A-4dnhA:
undetectable
1og5A-4dnhA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Mycobacterium
tuberculosis)
PF00378
(ECH_1)
5 PHE A 110
PHE A  58
LEU A  89
LEU A  26
PHE A  83
None
1.21A 1og5A-4fn7A:
undetectable
1og5A-4fn7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijr D-ARABINOSE
DEHYDROGENASE
[NAD(P)+] HEAVY
CHAIN


(Saccharomyces
cerevisiae)
PF00248
(Aldo_ket_red)
5 LEU A  27
LEU A 127
ASN A  29
LEU A 174
LEU A 179
None
1.03A 1og5A-4ijrA:
undetectable
1og5A-4ijrA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxc FEFE-HYDROGENASE
MATURASE


(Thermotoga
maritima)
PF04055
(Radical_SAM)
PF06968
(BATS)
5 PHE A 216
LEU A 215
LEU A 259
LEU A 184
PHE A 222
None
None
None
CSO  A 183 ( 4.4A)
None
1.24A 1og5A-4jxcA:
undetectable
1og5A-4jxcA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5o PUTATIVE GLUTATHIONE
TRANSFERASE


(Clonorchis
sinensis)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 LEU A 102
ALA A 158
LEU A  19
PRO A  16
LEU A  72
None
1.23A 1og5A-4l5oA:
undetectable
1og5A-4l5oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4miv N-SULPHOGLUCOSAMINE
SULPHOHYDROLASE


(Homo sapiens)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 PHE A 457
LEU A 461
ALA A 452
LEU A 386
PHE A 384
None
1.07A 1og5A-4mivA:
undetectable
1og5A-4mivA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oo2 CHLOROPHENOL-4-MONOO
XYGENASE


(Streptomyces
globisporus)
PF03241
(HpaB)
PF11794
(HpaB_N)
5 PHE A 307
ALA A 305
LEU A 373
PRO A 374
LEU A  99
None
1.15A 1og5A-4oo2A:
undetectable
1og5A-4oo2A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psu ALPHA/BETA HYDROLASE

(Rhodopseudomonas
palustris)
PF12697
(Abhydrolase_6)
5 LEU A  59
ALA A  60
LEU A  45
PRO A  15
LEU A 198
None
1.22A 1og5A-4psuA:
undetectable
1og5A-4psuA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ud8 FAD-BINDING AND BBE
DOMAIN-CONTAINING
PROTEIN


(Arabidopsis
thaliana)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 ARG A 198
PHE A 317
ALA A 315
LEU A 335
LEU A 285
None
1.14A 1og5A-4ud8A:
undetectable
1og5A-4ud8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens)
PF05450
(Nicastrin)
5 PHE A 287
LEU A 125
PRO A 136
LEU A 171
PHE A 103
None
1.09A 1og5A-4uisA:
undetectable
1og5A-4uisA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0o 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3 PROTEIN 2


(Vibrio cholerae)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ARG A  46
LEU A 143
LEU A  15
PRO A  16
LEU A 338
None
0.89A 1og5A-4x0oA:
undetectable
1og5A-4x0oA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Drosophila
melanogaster)
PF07034
(ORC3_N)
5 LEU C 240
ALA C  99
PHE C  82
LEU C 238
THR C 118
None
1.12A 1og5A-4xgcC:
undetectable
1og5A-4xgcC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3


(Drosophila
melanogaster)
PF07034
(ORC3_N)
5 PHE C 290
LEU C 593
PHE C 400
THR C 296
PHE C 596
None
1.23A 1og5A-4xgcC:
undetectable
1og5A-4xgcC:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y61 SLIT AND NTRK-LIKE
PROTEIN 2


(Mus musculus)
PF13855
(LRR_8)
5 LEU B 165
ALA B 141
LEU B 125
ASN B 168
LEU B  98
None
1.04A 1og5A-4y61B:
undetectable
1og5A-4y61B:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z6g MICROTUBULE-ACTIN
CROSS-LINKING FACTOR
1, ISOFORMS 1/2/3/5


(Homo sapiens)
PF00307
(CH)
5 PHE A 112
LEU A 110
ALA A 109
LEU A 139
LEU A  82
None
1.22A 1og5A-4z6gA:
undetectable
1og5A-4z6gA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buk FADH2-DEPENDENT
HALOGENASE


(Streptomyces
sp. CNQ-418)
PF04820
(Trp_halogenase)
5 PHE A 383
LEU A 379
PHE A  90
LEU A 400
PHE A 372
None
1.21A 1og5A-5bukA:
undetectable
1og5A-5bukA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ccx TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRMT61A
TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6


(Homo sapiens)
PF04189
(Gcd10p)
PF08704
(GCD14)
5 LEU A  87
LEU A 281
THR B 428
LEU A 234
PRO A 235
SAH  A 301 (-4.4A)
None
None
None
None
1.09A 1og5A-5ccxA:
undetectable
1og5A-5ccxA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d17 TRANSPOSON TN7
TRANSPOSITION
PROTEIN TNSE


(Escherichia
coli)
no annotation 5 PHE A 446
LEU A 465
PHE A 409
LEU A 449
LEU A 399
None
1.07A 1og5A-5d17A:
undetectable
1og5A-5d17A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT


(Homo sapiens)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol)
5 PHE C 542
LEU C 563
ALA C 749
LEU C 647
PHE C 622
None
1.16A 1og5A-5exrC:
undetectable
1og5A-5exrC:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f17 NON-STRUCTURAL
PROTEIN 11


(Equine
arteritis virus)
no annotation 5 LEU A 159
ALA A 158
PHE A 105
LEU A 148
PRO A 149
None
1.11A 1og5A-5f17A:
undetectable
1og5A-5f17A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fwm HEAT SHOCK PROTEIN
HSP 90 BETA


(Homo sapiens)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 LEU A 282
LEU A 215
ASN A 283
THR A  89
LEU A  51
None
1.05A 1og5A-5fwmA:
undetectable
1og5A-5fwmA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1a ICLR TRANSCRIPTION
FACTOR HOMOLOG


(Microbacterium
sp.)
PF01614
(IclR)
PF09339
(HTH_IclR)
5 ARG A  83
LEU A  89
LEU A 105
THR A 243
LEU A 245
None
1.20A 1og5A-5h1aA:
undetectable
1og5A-5h1aA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA


(Streptococcus
pneumoniae)
PF13481
(AAA_25)
PF13541
(ChlI)
5 PHE A 209
LEU A 167
LEU A 197
THR A 232
LEU A  81
None
1.15A 1og5A-5lkmA:
undetectable
1og5A-5lkmA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnk MITOCHONDRIAL
COMPLEX I, ND5
SUBUNIT


(Ovis aries)
PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N)
PF06455
(NADH5_C)
5 PHE L 189
LEU L 190
LEU L 211
PRO L 212
LEU L 216
None
1.23A 1og5A-5lnkL:
undetectable
1og5A-5lnkL:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl7 CALPONIN HOMOLOGY
DOMAIN PROTEIN
PUTATIVE


(Entamoeba
histolytica)
no annotation 5 PHE A  80
LEU A  78
ALA A  77
LEU A 107
LEU A  49
None
1.19A 1og5A-5nl7A:
undetectable
1og5A-5nl7A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
5 PHE T3296
PHE T1129
LEU T3288
LEU T3321
LEU T3314
None
1.24A 1og5A-5ojsT:
undetectable
1og5A-5ojsT:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugf PURINE NUCLEOSIDE
PHOSPHORYLASE


(Homo sapiens)
PF01048
(PNP_UDP_1)
5 ALA A 216
PHE A 124
ASN A 115
LEU A 271
PHE A 238
None
None
PO4  A 301 (-4.9A)
None
None
1.01A 1og5A-5ugfA:
undetectable
1og5A-5ugfA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyk CHIMERA PROTEIN OF
BRS DOMAIN OF BRAF
AND CC-SAM DOMAIN OF
KSR1,SERINE/THREONIN
E-PROTEIN KINASE
B-RAF


(Homo sapiens)
no annotation 5 ARG A 159
LEU A 167
ALA A 163
LEU A 132
LEU A  55
None
1.25A 1og5A-5vykA:
undetectable
1og5A-5vykA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjg VACUOLAR PROTEIN 8

(Saccharomyces
cerevisiae)
PF00514
(Arm)
5 LEU A 109
ALA A 108
LEU A  94
THR A  53
LEU A  49
None
1.25A 1og5A-5xjgA:
undetectable
1og5A-5xjgA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 7 ARG A  97
LEU A 208
ASN A 218
LEU A 366
PRO A 367
LEU A 388
PHE A 476
HEM  A 504 (-2.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.86A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 7 ARG A  97
LEU A 208
THR A 364
LEU A 366
PRO A 367
LEU A 388
PHE A 476
HEM  A 504 (-2.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.73A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 6 ARG A  97
PHE A 100
ALA A 103
ASN A 218
LEU A 366
PRO A 367
HEM  A 504 (-2.5A)
LSN  A 503 (-4.1A)
LSN  A 503 ( 4.0A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
0.71A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 7 ARG A  97
PHE A 100
LEU A 208
ASN A 218
LEU A 366
PRO A 367
LEU A 388
HEM  A 504 (-2.5A)
LSN  A 503 (-4.1A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
0.81A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 7 ARG A  97
PHE A 100
LEU A 208
THR A 364
LEU A 366
PRO A 367
LEU A 388
HEM  A 504 (-2.5A)
LSN  A 503 (-4.1A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
HEM  A 504 ( 4.4A)
LSN  A 503 (-4.1A)
LSN  A 503 (-4.6A)
0.84A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 5 LEU A 102
LEU A 208
ASN A 218
LEU A 388
PHE A 476
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
1.09A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 5 LEU A 102
LEU A 208
THR A 364
LEU A 388
PHE A 476
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
LSN  A 503 (-3.8A)
0.94A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 5 PHE A 100
LEU A 102
LEU A 208
ASN A 218
LEU A 388
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.1A)
LSN  A 503 (-4.6A)
1.16A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens)
no annotation 5 PHE A 100
LEU A 102
LEU A 208
THR A 364
LEU A 388
LSN  A 503 (-4.1A)
LSN  A 503 (-3.5A)
LSN  A 501 (-3.9A)
LSN  A 503 (-3.2A)
LSN  A 503 (-4.6A)
1.08A 1og5A-5xxiA:
53.4
1og5A-5xxiA:
96.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anu SPECTRIN BETA CHAIN,
NON-ERYTHROCYTIC 2


(Homo sapiens)
no annotation 5 PHE f1125
LEU f1123
ALA f1122
LEU f1152
LEU f1094
None
1.14A 1og5A-6anuf:
undetectable
1og5A-6anuf:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c01 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 3


(Homo sapiens)
no annotation 5 PHE A 169
LEU A 370
ALA A 371
PRO A 324
LEU A 342
None
1.25A 1og5A-6c01A:
undetectable
1og5A-6c01A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT


(Homo sapiens)
no annotation 5 ALA A 283
LEU A 264
LEU A 296
PRO A 297
LEU A 301
None
0.86A 1og5A-6c9mA:
undetectable
1og5A-6c9mA:
10.32