SIMILAR PATTERNS OF AMINO ACIDS FOR 1OG5_A_SWFA502
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5i | PLASMINOGENACTIVATOR (Desmodusrotundus) |
PF00089(Trypsin) | 5 | LEU A 199LEU A 162LEU A 128PRO A 124LEU A 235 | None | 1.11A | 1og5A-1a5iA:undetectable | 1og5A-1a5iA:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aw9 | GLUTATHIONES-TRANSFERASE III (Zea mays) |
PF00043(GST_C)PF02798(GST_N) | 5 | LEU A 157ALA A 158THR A 84LEU A 87PRO A 88 | None | 1.24A | 1og5A-1aw9A:undetectable | 1og5A-1aw9A:20.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c4o | DNA NUCLEOTIDEEXCISION REPAIRENZYME UVRB (Thermusthermophilus) |
PF00271(Helicase_C)PF04851(ResIII)PF12344(UvrB) | 5 | PHE A 394LEU A 396LEU A 332LEU A 378PHE A 31 | NoneBOG A9998 ( 4.5A)NoneNoneNone | 1.22A | 1og5A-1c4oA:0.0 | 1og5A-1c4oA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ekq | HYDROXYETHYLTHIAZOLEKINASE (Bacillussubtilis) |
PF02110(HK) | 5 | PHE A 207ALA A 218LEU A 183LEU A 200LEU A 39 | None | 1.17A | 1og5A-1ekqA:0.0 | 1og5A-1ekqA:18.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i41 | CYSTATHIONINEGAMMA-SYNTHASE (Nicotianatabacum) |
PF01053(Cys_Met_Meta_PP) | 5 | LEU A 147ALA A 148LEU A 291LEU A 133LEU A 256 | None | 1.14A | 1og5A-1i41A:undetectable | 1og5A-1i41A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kph | CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPIDSYNTHASE 1 (Mycobacteriumtuberculosis) |
PF02353(CMAS) | 5 | PHE A 151LEU A 153ALA A 154THR A 168PHE A 139 | None | 1.04A | 1og5A-1kphA:0.2 | 1og5A-1kphA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mew | INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE (Tritrichomonassuis) |
PF00478(IMPDH)PF00571(CBS) | 5 | LEU A 369ALA A 370LEU A 54PRO A 53LEU A 33 | None | 1.16A | 1og5A-1mewA:undetectable | 1og5A-1mewA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mtp | SERINE PROTEINASEINHIBITOR (SERPIN),CHAIN A (Thermobifidafusca) |
PF00079(Serpin) | 5 | LEU A 286ALA A 50LEU A 279PRO A 66LEU A 70 | None | 1.23A | 1og5A-1mtpA:undetectable | 1og5A-1mtpA:20.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nne | DNA MISMATCH REPAIRPROTEIN MUTS (Thermusaquaticus) |
PF00488(MutS_V)PF01624(MutS_I)PF05188(MutS_II)PF05190(MutS_IV)PF05192(MutS_III) | 5 | ARG A 354LEU A 375LEU A 517THR A 281LEU A 326 | None | 1.05A | 1og5A-1nneA:0.0 | 1og5A-1nneA:20.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nr6 | CYTOCHROME P450 2C5 (Oryctolaguscuniculus) |
PF00067(p450) | 6 | ARG A 97LEU A 208PHE A 114THR A 361LEU A 363PRO A 364 | HEM A 500 (-2.6A)NoneDIF A 501 (-4.5A)NoneHEM A 500 (-4.0A)None | 1.14A | 1og5A-1nr6A:55.1 | 1og5A-1nr6A:77.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1olp | ALPHA-TOXIN (Clostridiumsardiniense) |
PF00882(Zn_dep_PLPC)PF01477(PLAT) | 5 | ARG A 99PHE A 101LEU A 121ALA A 102PHE A 185 | None | 1.23A | 1og5A-1olpA:undetectable | 1og5A-1olpA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pui | PROBABLE GTP-BINDINGPROTEIN ENGB (Escherichiacoli) |
PF01926(MMR_HSR1) | 5 | PHE A 31LEU A 79ALA A 32LEU A 103LEU A 193 | None | 1.05A | 1og5A-1puiA:undetectable | 1og5A-1puiA:18.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rdr | POLIOVIRUS 3DPOLYMERASE (Enterovirus C) |
PF00680(RdRP_1) | 5 | LEU A 420ALA A 421PHE A 432LEU A 447PRO A 448 | None | 1.04A | 1og5A-1rdrA:undetectable | 1og5A-1rdrA:21.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ugj | RIKEN CDNA2310057J16 PROTEIN (Mus musculus) |
PF08683(CAMSAP_CKK) | 5 | ALA A 26THR A 72LEU A 57LEU A 83PHE A 56 | None | 1.25A | 1og5A-1ugjA:undetectable | 1og5A-1ugjA:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vfn | PURINE-NUCLEOSIDEPHOSPHORYLASE (Bos taurus) |
PF01048(PNP_UDP_1) | 5 | ALA A 216PHE A 124ASN A 115LEU A 271PHE A 238 | None | 1.10A | 1og5A-1vfnA:undetectable | 1og5A-1vfnA:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w3f | HEMOLYTIC LECTINFROM LAETIPORUSSULPHUREUS (Laetiporussulphureus) |
PF03318(ETX_MTX2) | 5 | PHE A 146LEU A 147LEU A 11PRO A 7LEU A 50 | None | 1.21A | 1og5A-1w3fA:undetectable | 1og5A-1w3fA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w5d | PENICILLIN-BINDINGPROTEIN (Bacillussubtilis) |
PF02113(Peptidase_S13) | 5 | LEU A 381ALA A 410LEU A 365THR A 427LEU A 459 | None | 1.14A | 1og5A-1w5dA:undetectable | 1og5A-1w5dA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wle | SERYL-TRNASYNTHETASE (Bos taurus) |
PF00587(tRNA-synt_2b) | 5 | LEU A 59ALA A 56LEU A 153PRO A 154LEU A 381 | None | 1.22A | 1og5A-1wleA:undetectable | 1og5A-1wleA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xr5 | GENOME POLYPROTEIN (Rhinovirus B) |
PF00680(RdRP_1) | 5 | LEU A 419ALA A 420PHE A 431LEU A 446PRO A 447 | None | 1.20A | 1og5A-1xr5A:undetectable | 1og5A-1xr5A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zcw | AROMATICPRENYLTRANSFERASE (Streptomycessp. CL190) |
PF11468(PTase_Orf2) | 5 | ALA A 122PHE A 124LEU A 94THR A 218LEU A 174 | None | 1.20A | 1og5A-1zcwA:undetectable | 1og5A-1zcwA:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zrz | PROTEIN KINASE C,IOTA (Homo sapiens) |
PF00069(Pkinase)PF00433(Pkinase_C) | 5 | LEU A 341ALA A 346LEU A 331LEU A 430LEU A 488 | None | 1.16A | 1og5A-1zrzA:undetectable | 1og5A-1zrzA:21.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bw3 | TRANSPOSASE (Musca domestica) |
PF05699(Dimer_Tnp_hAT)PF10683(DBD_Tnp_Hermes) | 5 | LEU A 557ALA A 558PRO A 437LEU A 440PHE A 434 | None | 1.23A | 1og5A-2bw3A:undetectable | 1og5A-2bw3A:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d5l | DIPEPTIDYLAMINOPEPTIDASE IV,PUTATIVE (Porphyromonasgingivalis) |
PF00326(Peptidase_S9)PF00930(DPPIV_N) | 5 | PHE A 689LEU A 688THR A 698PRO A 700LEU A 666 | None | 1.12A | 1og5A-2d5lA:undetectable | 1og5A-2d5lA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpo | METHYLASE YHHF (Escherichiacoli) |
PF03602(Cons_hypoth95) | 5 | PHE A 125LEU A 57PHE A 60LEU A 142LEU A 43 | None | 1.02A | 1og5A-2fpoA:undetectable | 1og5A-2fpoA:16.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3q | PROTEIN YBL047C (Saccharomycescerevisiae) |
PF00627(UBA) | 5 | PHE A1376LEU A1363PHE A1354LEU A1370LEU A1378 | None | 1.23A | 1og5A-2g3qA:undetectable | 1og5A-2g3qA:8.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gn1 | THREONINEDEHYDRATASECATABOLIC (Salmonellaenterica) |
PF00291(PALP) | 5 | LEU A 46LEU A 273LEU A 287PRO A 182LEU A 188 | NoneNoneNoneLLP A 58 ( 4.6A)LLP A 58 ( 4.5A) | 1.23A | 1og5A-2gn1A:undetectable | 1og5A-2gn1A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hnl | GLUTATHIONES-TRANSFERASE 1 (Onchocercavolvulus) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | PHE A 46LEU A 48ALA A 49LEU A 101LEU A 78 | None | 1.12A | 1og5A-2hnlA:undetectable | 1og5A-2hnlA:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iou | PERTACTINEXTRACELLULAR DOMAIN (Bordetellabronchiseptica) |
PF03212(Pertactin) | 5 | ARG G 484PHE G 483LEU G 526LEU G 539LEU G 452 | None | 1.23A | 1og5A-2iouG:undetectable | 1og5A-2iouG:20.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2nnj | CYTOCHROME P450 2C8 (Homo sapiens) |
PF00067(p450) | 5 | ARG A 97LEU A 208ASN A 217THR A 364PRO A 367 | HEM A 500 (-2.6A)225 A 501 ( 4.3A)NoneNone225 A 501 ( 4.7A) | 0.92A | 1og5A-2nnjA:55.0 | 1og5A-2nnjA:78.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pgg | RNA-DIRECTED RNAPOLYMERASE (Infectiousbursal diseasevirus) |
PF04197(Birna_RdRp) | 5 | LEU A 97LEU A 79LEU A 346PRO A 343LEU A 313 | None | 1.11A | 1og5A-2pggA:undetectable | 1og5A-2pggA:20.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyw | UNCHARACTERIZEDPROTEIN (Arabidopsisthaliana) |
PF01636(APH) | 5 | PHE A 310LEU A 309THR A 150LEU A 317LEU A 151 | None | 1.21A | 1og5A-2pywA:undetectable | 1og5A-2pywA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgn | TRNADELTA(2)-ISOPENTENYLPYROPHOSPHATETRANSFERASE (Bacillushalodurans) |
PF01715(IPPT) | 5 | LEU A 80ALA A 81LEU A 62THR A 101LEU A 103 | None | 1.19A | 1og5A-2qgnA:undetectable | 1og5A-2qgnA:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r9y | ALPHA-2-ANTIPLASMIN (Mus musculus) |
PF00079(Serpin) | 5 | LEU A 338ALA A 97LEU A 117PRO A 118LEU A 158 | None | 1.25A | 1og5A-2r9yA:undetectable | 1og5A-2r9yA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xka | FTSZ/TUBULIN-RELATEDPROTEIN (Bacillusthuringiensis) |
PF00091(Tubulin) | 5 | LEU A 56PHE A 79LEU A 115LEU A 148LEU A 135 | None | 1.22A | 1og5A-2xkaA:undetectable | 1og5A-2xkaA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xy9 | ANGIOTENSIN-CONVERTING ENZYME (Homo sapiens) |
PF01401(Peptidase_M2) | 5 | LEU A 603LEU A 247ASN A 607LEU A 255LEU A 266 | None | 1.16A | 1og5A-2xy9A:undetectable | 1og5A-2xy9A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yvp | MUTT/NUDIX FAMILYPROTEIN (Thermusthermophilus) |
PF00293(NUDIX) | 5 | LEU A 144LEU A 70LEU A 47PRO A 48LEU A 91 | None | 1.03A | 1og5A-2yvpA:undetectable | 1og5A-2yvpA:16.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywa | HYPOTHETICAL PROTEINTTHA0048 (Thermusthermophilus) |
PF08780(NTase_sub_bind) | 5 | LEU A 105ALA A 104PHE A 74THR A 85LEU A 81 | None | 1.18A | 1og5A-2ywaA:undetectable | 1og5A-2ywaA:14.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zyj | ALPHA-AMINODIPATEAMINOTRANSFERASE (Thermusthermophilus) |
PF00155(Aminotran_1_2) | 5 | PHE A 341LEU A 367LEU A 369THR A 29LEU A 28 | None | 1.11A | 1og5A-2zyjA:undetectable | 1og5A-2zyjA:20.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3e4e | CYTOCHROME P450 2E1 (Homo sapiens) |
PF00067(p450) | 5 | ARG A 100PHE A 116LEU A 210LEU A 368PRO A 369 | HEM A 500 (-2.4A)NoneNoneHEM A 500 (-3.6A)None | 0.71A | 1og5A-3e4eA:51.4 | 1og5A-3e4eA:59.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e5d | PUTATIVE GLYOXALASEI (Listeriamonocytogenes) |
PF00903(Glyoxalase) | 5 | PHE A 24LEU A 44ALA A 26LEU A 91PHE A 19 | None | 1.11A | 1og5A-3e5dA:undetectable | 1og5A-3e5dA:12.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eo7 | PUTATIVENITROREDUCTASE (Trichormusvariabilis) |
PF00881(Nitroreductase) | 5 | PHE A 355LEU A 352ALA A 351LEU A 475LEU A 326 | None | 1.21A | 1og5A-3eo7A:undetectable | 1og5A-3eo7A:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g0i | EPOXIDE HYDROLASE (Aspergillusniger) |
PF06441(EHN) | 5 | PHE A 164LEU A 200LEU A 149PRO A 150LEU A 94 | None | 1.23A | 1og5A-3g0iA:undetectable | 1og5A-3g0iA:23.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0g | DNA-DIRECTED RNAPOLYMERASE IISUBUNIT RPB1 (Schizosaccharomycespombe) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04990(RNA_pol_Rpb1_7)PF04992(RNA_pol_Rpb1_6)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | PHE A 93LEU A 302LEU A 211PRO A 210LEU A 208 | None | 1.13A | 1og5A-3h0gA:undetectable | 1og5A-3h0gA:15.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0u | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesavermitilis) |
PF00378(ECH_1) | 5 | ARG A 132PHE A 125ALA A 118LEU A 127LEU A 103 | None | 1.20A | 1og5A-3h0uA:undetectable | 1og5A-3h0uA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h95 | NUCLEOSIDEDIPHOSPHATE-LINKEDMOIETY X MOTIF 6 (Homo sapiens) |
PF00293(NUDIX) | 5 | PHE A 151LEU A 229ALA A 149LEU A 270PHE A 279 | None | 0.95A | 1og5A-3h95A:undetectable | 1og5A-3h95A:18.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNITA' (Sulfolobussolfataricus) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 5 | ALA A 472LEU A 418THR A 348PRO A 350PHE A 320 | None | 1.09A | 1og5A-3hkzA:undetectable | 1og5A-3hkzA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jc5 | DNA REPLICATIONCOMPLEX GINS PROTEINPSF3 (Saccharomycescerevisiae) |
PF05916(Sld5) | 5 | PHE C 80LEU C 75THR C 14LEU C 107PHE C 16 | None | 1.16A | 1og5A-3jc5C:2.2 | 1og5A-3jc5C:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kzw | CYTOSOLAMINOPEPTIDASE (Staphylococcusaureus) |
PF00883(Peptidase_M17)PF02789(Peptidase_M17_N) | 5 | PHE A 444ALA A 441LEU A 348LEU A 225PHE A 448 | None | 1.24A | 1og5A-3kzwA:undetectable | 1og5A-3kzwA:21.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi6 | ALPHA-GALACTOSIDASE (Lactobacillusbrevis) |
PF02065(Melibiase)PF16874(Glyco_hydro_36C)PF16875(Glyco_hydro_36N) | 5 | PHE A 90LEU A 180ALA A 179PHE A 291LEU A 103 | None | 1.24A | 1og5A-3mi6A:undetectable | 1og5A-3mi6A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mq2 | 16S RRNAMETHYLTRANSFERASE (Streptoalloteichustenebrarius) |
PF02390(Methyltransf_4) | 5 | ARG A 167ALA A 160LEU A 207LEU A 113LEU A 120 | None | 1.25A | 1og5A-3mq2A:undetectable | 1og5A-3mq2A:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nyq | MALONYL-COA LIGASE (Streptomycescoelicolor) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ARG A 200LEU A 191PHE A 5LEU A 139LEU A 167 | None | 1.12A | 1og5A-3nyqA:undetectable | 1og5A-3nyqA:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o7j | OHCU DECARBOXYLASE (Klebsiellapneumoniae) |
PF09349(OHCU_decarbox) | 6 | PHE A 7ASN A 8THR A 47LEU A 45LEU A 32PHE A 38 | None | 1.40A | 1og5A-3o7jA:undetectable | 1og5A-3o7jA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p6l | SUGAR PHOSPHATEISOMERASE/EPIMERASE (Parabacteroidesdistasonis) |
PF01261(AP_endonuc_2) | 5 | LEU A 93ALA A 94THR A 104LEU A 127PHE A 78 | None | 1.17A | 1og5A-3p6lA:undetectable | 1og5A-3p6lA:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pjp | TRANSCRIPTIONELONGATION FACTORSPT6 ([Candida]glabrata) |
PF14633(SH2_2) | 5 | PHE A1416LEU A1418LEU A1394THR A1350PHE A1392 | None | 1.20A | 1og5A-3pjpA:undetectable | 1og5A-3pjpA:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tc1 | OCTAPRENYLPYROPHOSPHATESYNTHASE (Helicobacterpylori) |
PF00348(polyprenyl_synt) | 5 | ARG A 39LEU A 46LEU A 295LEU A 38LEU A 6 | None | 1.20A | 1og5A-3tc1A:undetectable | 1og5A-3tc1A:20.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3w0k | BIFUNCTIONALENDOMANNANASE/ENDOGLUCANASE (Caldanaerobiuspolysaccharolyticus) |
PF00150(Cellulase) | 5 | PHE A 30LEU A 28ALA A 27LEU A 322PHE A 36 | None | 1.22A | 1og5A-3w0kA:undetectable | 1og5A-3w0kA:19.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wec | CYTOCHROME P450 (Rhodococcuserythropolis) |
PF00067(p450) | 5 | LEU A 399ALA A 300LEU A 186ASN A 260LEU A 371 | AUI A 502 (-4.4A)AUI A 502 ( 3.7A)NoneNoneNone | 1.25A | 1og5A-3wecA:28.5 | 1og5A-3wecA:23.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b3i | FATTY ACIDBETA-OXIDATIONCOMPLEX ALPHA-CHAINFADB (Mycobacteriumtuberculosis) |
PF00378(ECH_1)PF00725(3HCDH)PF02737(3HCDH_N) | 5 | ARG A 127LEU A 114ALA A 113LEU A 122LEU A 95 | NoneCOA A1730 ( 4.4A)NoneNoneNone | 1.24A | 1og5A-4b3iA:undetectable | 1og5A-4b3iA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btg | MAJOR INNER PROTEINP1 (Pseudomonasvirus phi6) |
no annotation | 5 | PHE A 291LEU A 290PHE A 484LEU A 186LEU A 516 | None | 1.23A | 1og5A-4btgA:undetectable | 1og5A-4btgA:21.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dnh | UNCHARACTERIZEDPROTEIN (Sinorhizobiummeliloti) |
PF06187(DUF993) | 5 | ALA A 42PHE A 68LEU A 77LEU A 115PHE A 39 | None | 1.23A | 1og5A-4dnhA:undetectable | 1og5A-4dnhA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fn7 | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Mycobacteriumtuberculosis) |
PF00378(ECH_1) | 5 | PHE A 110PHE A 58LEU A 89LEU A 26PHE A 83 | None | 1.21A | 1og5A-4fn7A:undetectable | 1og5A-4fn7A:17.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ijr | D-ARABINOSEDEHYDROGENASE[NAD(P)+] HEAVYCHAIN (Saccharomycescerevisiae) |
PF00248(Aldo_ket_red) | 5 | LEU A 27LEU A 127ASN A 29LEU A 174LEU A 179 | None | 1.03A | 1og5A-4ijrA:undetectable | 1og5A-4ijrA:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxc | FEFE-HYDROGENASEMATURASE (Thermotogamaritima) |
PF04055(Radical_SAM)PF06968(BATS) | 5 | PHE A 216LEU A 215LEU A 259LEU A 184PHE A 222 | NoneNoneNoneCSO A 183 ( 4.4A)None | 1.24A | 1og5A-4jxcA:undetectable | 1og5A-4jxcA:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l5o | PUTATIVE GLUTATHIONETRANSFERASE (Clonorchissinensis) |
PF02798(GST_N)PF14497(GST_C_3) | 5 | LEU A 102ALA A 158LEU A 19PRO A 16LEU A 72 | None | 1.23A | 1og5A-4l5oA:undetectable | 1og5A-4l5oA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4miv | N-SULPHOGLUCOSAMINESULPHOHYDROLASE (Homo sapiens) |
PF00884(Sulfatase)PF16347(DUF4976) | 5 | PHE A 457LEU A 461ALA A 452LEU A 386PHE A 384 | None | 1.07A | 1og5A-4mivA:undetectable | 1og5A-4mivA:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oo2 | CHLOROPHENOL-4-MONOOXYGENASE (Streptomycesglobisporus) |
PF03241(HpaB)PF11794(HpaB_N) | 5 | PHE A 307ALA A 305LEU A 373PRO A 374LEU A 99 | None | 1.15A | 1og5A-4oo2A:undetectable | 1og5A-4oo2A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4psu | ALPHA/BETA HYDROLASE (Rhodopseudomonaspalustris) |
PF12697(Abhydrolase_6) | 5 | LEU A 59ALA A 60LEU A 45PRO A 15LEU A 198 | None | 1.22A | 1og5A-4psuA:undetectable | 1og5A-4psuA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ud8 | FAD-BINDING AND BBEDOMAIN-CONTAININGPROTEIN (Arabidopsisthaliana) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | ARG A 198PHE A 317ALA A 315LEU A 335LEU A 285 | None | 1.14A | 1og5A-4ud8A:undetectable | 1og5A-4ud8A:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uis | GAMMA-SECRETASE (Homo sapiens) |
PF05450(Nicastrin) | 5 | PHE A 287LEU A 125PRO A 136LEU A 171PHE A 103 | None | 1.09A | 1og5A-4uisA:undetectable | 1og5A-4uisA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ARG A 46LEU A 143LEU A 15PRO A 16LEU A 338 | None | 0.89A | 1og5A-4x0oA:undetectable | 1og5A-4x0oA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Drosophilamelanogaster) |
PF07034(ORC3_N) | 5 | LEU C 240ALA C 99PHE C 82LEU C 238THR C 118 | None | 1.12A | 1og5A-4xgcC:undetectable | 1og5A-4xgcC:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xgc | ORIGIN RECOGNITIONCOMPLEX SUBUNIT 3 (Drosophilamelanogaster) |
PF07034(ORC3_N) | 5 | PHE C 290LEU C 593PHE C 400THR C 296PHE C 596 | None | 1.23A | 1og5A-4xgcC:undetectable | 1og5A-4xgcC:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y61 | SLIT AND NTRK-LIKEPROTEIN 2 (Mus musculus) |
PF13855(LRR_8) | 5 | LEU B 165ALA B 141LEU B 125ASN B 168LEU B 98 | None | 1.04A | 1og5A-4y61B:undetectable | 1og5A-4y61B:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z6g | MICROTUBULE-ACTINCROSS-LINKING FACTOR1, ISOFORMS 1/2/3/5 (Homo sapiens) |
PF00307(CH) | 5 | PHE A 112LEU A 110ALA A 109LEU A 139LEU A 82 | None | 1.22A | 1og5A-4z6gA:undetectable | 1og5A-4z6gA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5buk | FADH2-DEPENDENTHALOGENASE (Streptomycessp. CNQ-418) |
PF04820(Trp_halogenase) | 5 | PHE A 383LEU A 379PHE A 90LEU A 400PHE A 372 | None | 1.21A | 1og5A-5bukA:undetectable | 1og5A-5bukA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ccx | TRNA(ADENINE(58)-N(1))-METHYLTRANSFERASECATALYTIC SUBUNITTRMT61ATRNA(ADENINE(58)-N(1))-METHYLTRANSFERASENON-CATALYTICSUBUNIT TRM6 (Homo sapiens) |
PF04189(Gcd10p)PF08704(GCD14) | 5 | LEU A 87LEU A 281THR B 428LEU A 234PRO A 235 | SAH A 301 (-4.4A)NoneNoneNoneNone | 1.09A | 1og5A-5ccxA:undetectable | 1og5A-5ccxA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d17 | TRANSPOSON TN7TRANSPOSITIONPROTEIN TNSE (Escherichiacoli) |
no annotation | 5 | PHE A 446LEU A 465PHE A 409LEU A 449LEU A 399 | None | 1.07A | 1og5A-5d17A:undetectable | 1og5A-5d17A:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5exr | DNA POLYMERASE ALPHACATALYTIC SUBUNIT (Homo sapiens) |
PF00136(DNA_pol_B)PF03104(DNA_pol_B_exo1)PF08996(zf-DNA_Pol) | 5 | PHE C 542LEU C 563ALA C 749LEU C 647PHE C 622 | None | 1.16A | 1og5A-5exrC:undetectable | 1og5A-5exrC:17.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f17 | NON-STRUCTURALPROTEIN 11 (Equinearteritis virus) |
no annotation | 5 | LEU A 159ALA A 158PHE A 105LEU A 148PRO A 149 | None | 1.11A | 1og5A-5f17A:undetectable | 1og5A-5f17A:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fwm | HEAT SHOCK PROTEINHSP 90 BETA (Homo sapiens) |
PF00183(HSP90)PF02518(HATPase_c) | 5 | LEU A 282LEU A 215ASN A 283THR A 89LEU A 51 | None | 1.05A | 1og5A-5fwmA:undetectable | 1og5A-5fwmA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h1a | ICLR TRANSCRIPTIONFACTOR HOMOLOG (Microbacteriumsp.) |
PF01614(IclR)PF09339(HTH_IclR) | 5 | ARG A 83LEU A 89LEU A 105THR A 243LEU A 245 | None | 1.20A | 1og5A-5h1aA:undetectable | 1og5A-5h1aA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lkm | DNA REPAIR PROTEINRADA (Streptococcuspneumoniae) |
PF13481(AAA_25)PF13541(ChlI) | 5 | PHE A 209LEU A 167LEU A 197THR A 232LEU A 81 | None | 1.15A | 1og5A-5lkmA:undetectable | 1og5A-5lkmA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnk | MITOCHONDRIALCOMPLEX I, ND5SUBUNIT (Ovis aries) |
PF00361(Proton_antipo_M)PF00662(Proton_antipo_N)PF06455(NADH5_C) | 5 | PHE L 189LEU L 190LEU L 211PRO L 212LEU L 216 | None | 1.23A | 1og5A-5lnkL:undetectable | 1og5A-5lnkL:22.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nl7 | CALPONIN HOMOLOGYDOMAIN PROTEINPUTATIVE (Entamoebahistolytica) |
no annotation | 5 | PHE A 80LEU A 78ALA A 77LEU A 107LEU A 49 | None | 1.19A | 1og5A-5nl7A:undetectable | 1og5A-5nl7A:10.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 5 | PHE T3296PHE T1129LEU T3288LEU T3321LEU T3314 | None | 1.24A | 1og5A-5ojsT:undetectable | 1og5A-5ojsT:8.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ugf | PURINE NUCLEOSIDEPHOSPHORYLASE (Homo sapiens) |
PF01048(PNP_UDP_1) | 5 | ALA A 216PHE A 124ASN A 115LEU A 271PHE A 238 | NoneNonePO4 A 301 (-4.9A)NoneNone | 1.01A | 1og5A-5ugfA:undetectable | 1og5A-5ugfA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyk | CHIMERA PROTEIN OFBRS DOMAIN OF BRAFAND CC-SAM DOMAIN OFKSR1,SERINE/THREONINE-PROTEIN KINASEB-RAF (Homo sapiens) |
no annotation | 5 | ARG A 159LEU A 167ALA A 163LEU A 132LEU A 55 | None | 1.25A | 1og5A-5vykA:undetectable | 1og5A-5vykA:10.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xjg | VACUOLAR PROTEIN 8 (Saccharomycescerevisiae) |
PF00514(Arm) | 5 | LEU A 109ALA A 108LEU A 94THR A 53LEU A 49 | None | 1.25A | 1og5A-5xjgA:undetectable | 1og5A-5xjgA:23.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 7 | ARG A 97LEU A 208ASN A 218LEU A 366PRO A 367LEU A 388PHE A 476 | HEM A 504 (-2.5A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.86A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 7 | ARG A 97LEU A 208THR A 364LEU A 366PRO A 367LEU A 388PHE A 476 | HEM A 504 (-2.5A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.73A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 6 | ARG A 97PHE A 100ALA A 103ASN A 218LEU A 366PRO A 367 | HEM A 504 (-2.5A)LSN A 503 (-4.1A)LSN A 503 ( 4.0A)LSN A 503 (-3.1A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A) | 0.71A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 7 | ARG A 97PHE A 100LEU A 208ASN A 218LEU A 366PRO A 367LEU A 388 | HEM A 504 (-2.5A)LSN A 503 (-4.1A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A) | 0.81A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 7 | ARG A 97PHE A 100LEU A 208THR A 364LEU A 366PRO A 367LEU A 388 | HEM A 504 (-2.5A)LSN A 503 (-4.1A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)HEM A 504 ( 4.4A)LSN A 503 (-4.1A)LSN A 503 (-4.6A) | 0.84A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 5 | LEU A 102LEU A 208ASN A 218LEU A 388PHE A 476 | LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 1.09A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 5 | LEU A 102LEU A 208THR A 364LEU A 388PHE A 476 | LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)LSN A 503 (-4.6A)LSN A 503 (-3.8A) | 0.94A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 5 | PHE A 100LEU A 102LEU A 208ASN A 218LEU A 388 | LSN A 503 (-4.1A)LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.1A)LSN A 503 (-4.6A) | 1.16A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5xxi | CYTOCHROME P450 2C9 (Homo sapiens) |
no annotation | 5 | PHE A 100LEU A 102LEU A 208THR A 364LEU A 388 | LSN A 503 (-4.1A)LSN A 503 (-3.5A)LSN A 501 (-3.9A)LSN A 503 (-3.2A)LSN A 503 (-4.6A) | 1.08A | 1og5A-5xxiA:53.4 | 1og5A-5xxiA:96.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6anu | SPECTRIN BETA CHAIN,NON-ERYTHROCYTIC 2 (Homo sapiens) |
no annotation | 5 | PHE f1125LEU f1123ALA f1122LEU f1152LEU f1094 | None | 1.14A | 1og5A-6anuf:undetectable | 1og5A-6anuf:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c01 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 3 (Homo sapiens) |
no annotation | 5 | PHE A 169LEU A 370ALA A 371PRO A 324LEU A 342 | None | 1.25A | 1og5A-6c01A:undetectable | 1og5A-6c01A:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c9m | N-ALPHA-ACETYLTRANSFERASE 15, NATAAUXILIARY SUBUNIT (Homo sapiens) |
no annotation | 5 | ALA A 283LEU A 264LEU A 296PRO A 297LEU A 301 | None | 0.86A | 1og5A-6c9mA:undetectable | 1og5A-6c9mA:10.32 |