SIMILAR PATTERNS OF AMINO ACIDS FOR 1OE2_A_CUA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1amo NADPH-CYTOCHROME
P450 REDUCTASE

(Rattus
norvegicus) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 GLU A 304
HIS A 302
HIS A 470
 None
 0.71A 1oe2A-1amoA:
undetectable		 1oe2A-1amoA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddg SULFITE REDUCTASE
(NADPH) FLAVOPROTEIN
ALPHA-COMPONENT

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00667
(FAD_binding_1) 		3 GLU A 260
HIS A 258
HIS A 402
 None
 0.72A 1oe2A-1ddgA:
0.0		 1oe2A-1ddgA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1do6 SUPEROXIDE REDUCTASE

(Pyrococcus
furiosus) 		PF01880
(Desulfoferrodox) 		3 GLU A  14
HIS A  41
HIS A  16
 FE  A 200 (-2.9A)
FE  A 200 (-3.3A)
FE  A 200 (-3.3A)
 0.50A 1oe2A-1do6A:
undetectable		 1oe2A-1do6A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1juh QUERCETIN
2,3-DIOXYGENASE

(Aspergillus
japonicus) 		no annotation 3 GLU A  73
HIS A 112
HIS A  68
 CU  A 401 ( 2.8A)
CU  A 401 (-3.2A)
CU  A 401 (-3.2A)
 0.66A 1oe2A-1juhA:
1.1		 1oe2A-1juhA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kru GALACTOSIDE
O-ACETYLTRANSFERASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2) 		3 GLU A 120
HIS A 118
HIS A 119
 None
 0.69A 1oe2A-1kruA:
0.0		 1oe2A-1kruA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		3 GLU A 238
HIS A 235
HIS A 234
 ZN  A 963 (-3.8A)
None
ZN  A 963 ( 3.1A)
 0.66A 1oe2A-1li7A:
0.0		 1oe2A-1li7A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 GLU A 152
HIS A 148
HIS A 136
 ZN  A1374 (-2.3A)
ZN  A1374 (-3.3A)
ZN  A1374 (-3.4A)
 0.70A 1oe2A-1olpA:
0.0		 1oe2A-1olpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwr MANNOSE-6-PHOSPHATE
ISOMERASE

(Bacillus
subtilis) 		PF01238
(PMI_typeI) 		3 GLU A 116
HIS A 173
HIS A  98
 ZN  A 604 (-2.7A)
ZN  A 604 (-3.7A)
ZN  A 604 (-3.7A)
 0.60A 1oe2A-1qwrA:
0.0		 1oe2A-1qwrA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		3 GLU A  19
HIS A  95
HIS A  23
 None
 0.47A 1oe2A-1x42A:
undetectable		 1oe2A-1x42A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z05 TRANSCRIPTIONAL
REGULATOR, ROK
FAMILY

(Vibrio cholerae) 		PF00480
(ROK) 		3 GLU A 264
HIS A 256
HIS A 245
 None
None
ZN  A 406 (-3.2A)
 0.60A 1oe2A-1z05A:
undetectable		 1oe2A-1z05A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		3 GLU A 405
HIS A 346
HIS A 409
 None
 0.70A 1oe2A-2dwcA:
undetectable		 1oe2A-2dwcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ete OXALATE OXIDASE 1

(Hordeum vulgare) 		PF00190
(Cupin_1) 		3 GLU A  95
HIS A 137
HIS A  90
 MN  A 202 ( 2.6A)
MN  A 202 (-3.3A)
MN  A 202 ( 3.2A)
 0.70A 1oe2A-2eteA:
2.6		 1oe2A-2eteA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT

(Lumbricus
terrestris) 		PF00057
(Ldl_recept_a)
PF16915
(Eryth_link_C) 		3 GLU O 130
HIS O 145
HIS O 147
 None
 0.32A 1oe2A-2gtlO:
undetectable		 1oe2A-2gtlO:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		3 GLU A  72
HIS A  95
HIS A  47
 ZN  A1222 (-2.4A)
None
ZN  A1221 (-3.1A)
 0.70A 1oe2A-2hpiA:
undetectable		 1oe2A-2hpiA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hvb SUPEROXIDE REDUCTASE

(Pyrococcus
horikoshii) 		PF01880
(Desulfoferrodox) 		3 GLU A  23
HIS A  50
HIS A  25
 FE  A 201 (-3.7A)
FE  A 201 (-3.5A)
FE  A 201 (-3.3A)
 0.56A 1oe2A-2hvbA:
undetectable		 1oe2A-2hvbA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxg L-ARABINOSE
ISOMERASE

(Escherichia
coli) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		3 GLU A 333
HIS A 350
HIS A 450
 MN  A 501 (-2.6A)
MN  A 501 (-3.3A)
MN  A 501 (-3.6A)
 0.60A 1oe2A-2hxgA:
undetectable		 1oe2A-2hxgA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7t CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
73 KDA SUBUNIT

(Homo sapiens) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		3 GLU A 444
HIS A 446
HIS A 413
 None
 0.69A 1oe2A-2i7tA:
undetectable		 1oe2A-2i7tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		3 GLU A  38
HIS A  61
HIS A  59
 None
 0.58A 1oe2A-2is3A:
undetectable		 1oe2A-2is3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		3 GLU A 145
HIS A 182
HIS A 109
 ZN  A 401 ( 2.3A)
ZN  A 403 (-3.5A)
ZN  A 401 (-3.2A)
 0.47A 1oe2A-2nq9A:
undetectable		 1oe2A-2nq9A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		3 GLU A 131
HIS A 195
HIS A 143
 ZN  A 601 (-2.3A)
ZN  A 601 (-3.3A)
None
 0.70A 1oe2A-2p50A:
undetectable		 1oe2A-2p50A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 GLU A 126
HIS A 172
HIS A 109
 MN  A1540 ( 4.4A)
MN  A1540 (-3.4A)
MN  A1540 (-3.3A)
 0.58A 1oe2A-2v8jA:
undetectable		 1oe2A-2v8jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 GLU A 130
HIS A 109
HIS A 172
 MN  A1540 (-2.6A)
MN  A1540 (-3.3A)
MN  A1540 (-3.4A)
 0.71A 1oe2A-2v8jA:
undetectable		 1oe2A-2v8jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		3 GLU A 290
HIS A 329
HIS A 285
 MN  A1006 ( 2.3A)
MN  A1006 (-3.5A)
MN  A1006 ( 3.5A)
 0.66A 1oe2A-2vqaA:
undetectable		 1oe2A-2vqaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3g SIRV1 HYPOTHETICAL
PROTEIN ORF119

(Sulfolobus
islandicus
rod-shaped
virus 1) 		no annotation 3 GLU A  55
HIS A  64
HIS A  66
 None
 0.60A 1oe2A-2x3gA:
undetectable		 1oe2A-2x3gA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		3 GLU A 144
HIS A 181
HIS A 109
 ZN  A1287 ( 2.4A)
ZN  A1289 ( 3.3A)
ZN  A1287 (-3.3A)
 0.48A 1oe2A-2x7vA:
undetectable		 1oe2A-2x7vA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		3 GLU A 167
HIS A 170
HIS A 255
 None
PO4  A1474 (-4.5A)
None
 0.66A 1oe2A-2x98A:
undetectable		 1oe2A-2x98A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xig FERRIC UPTAKE
REGULATION PROTEIN

(Helicobacter
pylori) 		PF01475
(FUR) 		3 GLU A 110
HIS A  99
HIS A  97
 ZN  A1150 (-3.6A)
ZN  A1150 (-3.4A)
ZN  A1150 (-3.3A)
 0.67A 1oe2A-2xigA:
undetectable		 1oe2A-2xigA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y0o PROBABLE D-LYXOSE
KETOL-ISOMERASE

(Bacillus
subtilis) 		no annotation 3 GLU A  82
HIS A 137
HIS A  71
 ZN  A1173 (-2.6A)
ZN  A1173 (-3.4A)
ZN  A1173 (-3.4A)
 0.54A 1oe2A-2y0oA:
1.6		 1oe2A-2y0oA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7d 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Candidatus
Cloacimonas
acidaminovorans) 		PF05853
(BKACE) 		3 GLU A 230
HIS A  46
HIS A  48
 ZN  A 301 (-2.2A)
ZN  A 301 (-3.2A)
ZN  A 301 (-3.3A)
 0.65A 1oe2A-2y7dA:
undetectable		 1oe2A-2y7dA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		3 GLU A 214
HIS A  65
HIS A 210
 None
 0.71A 1oe2A-2yybA:
undetectable		 1oe2A-2yybA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayt PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB071

(Thermus
thermophilus) 		PF01261
(AP_endonuc_2) 		3 GLU A 136
HIS A 165
HIS A  96
 ZN  A 255 ( 2.2A)
ZN  A 257 ( 3.4A)
ZN  A 255 (-3.5A)
 0.60A 1oe2A-3aytA:
undetectable		 1oe2A-3aytA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bww PROTEIN OF UNKNOWN
FUNCTION
DUF692/COG3220

(Histophilus
somni) 		PF05114
(DUF692) 		3 GLU A 138
HIS A  94
HIS A  59
 FE  A 307 (-2.5A)
FE  A 307 ( 3.2A)
FE  A 307 (-3.4A)
 0.65A 1oe2A-3bwwA:
undetectable		 1oe2A-3bwwA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzj UV ENDONUCLEASE

(Thermus
thermophilus) 		PF03851
(UvdE) 		3 GLU A 175
HIS A 203
HIS A 143
 None
MN  A 281 (-3.3A)
None
 0.46A 1oe2A-3bzjA:
undetectable		 1oe2A-3bzjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		3 GLU A 250
HIS A  47
HIS A  49
 NI  A 298 (-2.6A)
NI  A 298 (-3.4A)
NI  A 298 (-3.5A)
 0.65A 1oe2A-3c6cA:
undetectable		 1oe2A-3c6cA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		3 GLU A 233
HIS A  51
HIS A  53
 ZN  A 302 (-2.2A)
ZN  A 302 (-3.2A)
ZN  A 302 (-3.2A)
 0.65A 1oe2A-3chvA:
undetectable		 1oe2A-3chvA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		3 GLU A 258
HIS A  49
HIS A  51
 ZN  A 311 (-2.5A)
ZN  A 311 (-3.3A)
ZN  A 311 (-3.4A)
 0.65A 1oe2A-3e02A:
undetectable		 1oe2A-3e02A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		3 GLU A 258
HIS A  49
HIS A  51
 ZN  A 500 (-2.4A)
ZN  A 500 (-3.3A)
ZN  A 500 (-3.4A)
 0.64A 1oe2A-3e49A:
undetectable		 1oe2A-3e49A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egj N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Vibrio cholerae) 		PF01979
(Amidohydro_1) 		3 GLU A 128
HIS A 192
HIS A 140
 NI  A 401 (-2.7A)
NI  A 401 (-3.4A)
NI  A 401 (-4.4A)
 0.68A 1oe2A-3egjA:
undetectable		 1oe2A-3egjA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyy PUTATIVE IRON UPTAKE
REGULATORY PROTEIN

(Streptomyces
coelicolor) 		PF01475
(FUR) 		3 GLU A 101
HIS A  90
HIS A  88
 ZN  A 147 ( 4.0A)
ZN  A 147 (-3.3A)
ZN  A 147 (-3.7A)
 0.67A 1oe2A-3eyyA:
undetectable		 1oe2A-3eyyA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f7w PUTATIVE
FRUCTOSAMINE-3-KINAS
E

(Thermobifida
fusca) 		PF03881
(Fructosamin_kin) 		3 GLU A 219
HIS A 257
HIS A 217
 None
 0.57A 1oe2A-3f7wA:
undetectable		 1oe2A-3f7wA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		3 GLU A 234
HIS A  51
HIS A  53
 MG  A 282 (-2.5A)
MG  A 282 (-3.4A)
MG  A 282 (-3.5A)
 0.70A 1oe2A-3fa5A:
undetectable		 1oe2A-3fa5A:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwp PHLG

(Pseudomonas
protegens) 		no annotation 3 GLU A 160
HIS A 129
HIS A 270
 ZN  A 295 (-2.9A)
ZN  A 295 (-3.3A)
ZN  A 295 (-3.3A)
 0.67A 1oe2A-3hwpA:
undetectable		 1oe2A-3hwpA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuk UNCHARACTERIZED
PROTEIN

(Paenarthrobacter
aurescens) 		PF05960
(DUF885) 		3 GLU A 386
HIS A 385
HIS A 391
 MG  A 560 (-2.6A)
MG  A 560 ( 4.9A)
MG  A 560 (-3.5A)
 0.68A 1oe2A-3iukA:
undetectable		 1oe2A-3iukA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmh D-LYXOSE ISOMERASE

(Escherichia
coli) 		PF07385
(Lyx_isomer) 		3 GLU A 110
HIS A 171
HIS A 105
 MN  A1001 (-2.6A)
MN  A1001 (-3.3A)
MN  A1001 (-3.2A)
 0.60A 1oe2A-3kmhA:
undetectable		 1oe2A-3kmhA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lot UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF05853
(BKACE) 		3 GLU A 261
HIS A  49
HIS A  51
 ZN  A 501 (-2.7A)
ZN  A 501 (-3.4A)
ZN  A 501 (-3.4A)
 0.71A 1oe2A-3lotA:
undetectable		 1oe2A-3lotA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7p FN1 PROTEIN

(Homo sapiens) 		PF00039
(fn1)
PF00040
(fn2) 		3 GLU A 474
HIS A 488
HIS A 581
 ZN  A 959 (-2.3A)
ZN  A 959 (-3.0A)
ZN  A 959 (-3.0A)
 0.70A 1oe2A-3m7pA:
undetectable		 1oe2A-3m7pA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no5 UNCHARACTERIZED
PROTEIN

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		3 GLU A 229
HIS A  47
HIS A  49
 ZN  A 275 (-2.6A)
ZN  A 275 (-3.3A)
ZN  A 275 (-3.3A)
 0.70A 1oe2A-3no5A:
undetectable		 1oe2A-3no5A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		3 GLU A 207
HIS A 205
HIS A 193
 None
 0.60A 1oe2A-3px2A:
undetectable		 1oe2A-3px2A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdk RIBULOKINASE

(Bacillus
halodurans) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLU A 439
HIS A 434
HIS A 441
 None
 0.71A 1oe2A-3qdkA:
undetectable		 1oe2A-3qdkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		3 GLU A 280
HIS A 319
HIS A 275
 MN  A 501 (-2.5A)
MN  A 501 (-3.4A)
MN  A 501 (-3.4A)
 0.67A 1oe2A-3s0mA:
1.6		 1oe2A-3s0mA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 3 GLU A 492
HIS A 494
HIS A  78
 None
CUK  A 702 (-3.3A)
None
 0.43A 1oe2A-3sbqA:
8.2		 1oe2A-3sbqA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sp1 CYSTEINYL-TRNA
SYNTHETASE

(Borreliella
burgdorferi) 		PF01406
(tRNA-synt_1e) 		3 GLU A 250
HIS A 247
HIS A 246
 ZN  A 481 (-3.9A)
None
ZN  A 481 (-3.3A)
 0.72A 1oe2A-3sp1A:
undetectable		 1oe2A-3sp1A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		3 GLU A 123
HIS A  94
HIS A 122
 UNX  A 607 ( 1.9A)
UNX  A 608 ( 3.4A)
UNX  A 607 ( 3.5A)
 0.69A 1oe2A-3t8lA:
undetectable		 1oe2A-3t8lA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tc3 UV DAMAGE
ENDONUCLEASE

(Sulfolobus
acidocaldarius) 		PF03851
(UvdE) 		3 GLU A 174
HIS A 202
HIS A 141
 MN  A 290 (-2.7A)
MN  A 290 (-4.4A)
None
 0.56A 1oe2A-3tc3A:
undetectable		 1oe2A-3tc3A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		3 GLU A 239
HIS A 236
HIS A 235
 ZN  A 461 (-4.2A)
None
ZN  A 461 (-3.4A)
 0.71A 1oe2A-3tqoA:
undetectable		 1oe2A-3tqoA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9j F-BOX/LRR-REPEAT
PROTEIN 5

(Homo sapiens) 		PF01814
(Hemerythrin) 		3 GLU A 130
HIS A 126
HIS A  80
 FE  A 200 ( 2.5A)
FE  A 200 (-3.5A)
FE  A 200 (-3.4A)
 0.61A 1oe2A-3u9jA:
undetectable		 1oe2A-3u9jA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		3 GLU A  89
HIS A  91
HIS A  68
 None
 0.64A 1oe2A-3uzuA:
undetectable		 1oe2A-3uzuA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ww3 L-RIBOSE ISOMERASE

(Cellulomonas
parahominis) 		no annotation 3 GLU A 113
HIS A 188
HIS A 108
 MN  A 401 (-2.5A)
MN  A 401 (-3.5A)
MN  A 401 (-3.3A)
 0.67A 1oe2A-3ww3A:
1.1		 1oe2A-3ww3A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 3 GLU A 639
HIS A 709
HIS A 632
 ZN  A 952 ( 2.4A)
ZN  A 952 (-3.3A)
ZN  A 952 (-3.3A)
 0.62A 1oe2A-4a7kA:
undetectable		 1oe2A-4a7kA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7p SUPEROXIDE REDUCTASE

(Giardia
intestinalis) 		PF01880
(Desulfoferrodox) 		3 GLU A  17
HIS A  40
HIS A  19
 FE  A 201 (-3.7A)
FE  A 201 (-3.4A)
FE  A 201 (-3.2A)
 0.66A 1oe2A-4d7pA:
undetectable		 1oe2A-4d7pA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd4 ARYLALKYLAMINE
N-ACETYLTRANSFERASE
LIKE 5B

(Aedes aegypti) 		PF00583
(Acetyltransf_1) 		3 GLU A  49
HIS A  44
HIS A  25
 None
 0.69A 1oe2A-4fd4A:
undetectable		 1oe2A-4fd4A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fms PROBABLE PORIN

(Pseudomonas
aeruginosa) 		no annotation 3 GLU B  38
HIS B  25
HIS B  23
 None
C8E  B 405 (-4.3A)
None
 0.64A 1oe2A-4fmsB:
undetectable		 1oe2A-4fmsB:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		3 GLU A  77
HIS A  73
HIS A 152
 MN  A 302 ( 2.6A)
MN  A 302 ( 3.4A)
MN  A 302 (-3.4A)
 0.42A 1oe2A-4lomA:
undetectable		 1oe2A-4lomA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		3 GLU A 180
HIS A 176
HIS A  47
 IYP  A 301 ( 2.6A)
MN  A 303 ( 3.4A)
MN  A 303 ( 3.6A)
 0.39A 1oe2A-4lomA:
undetectable		 1oe2A-4lomA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lql L-ARABINOSE
ISOMERASE

(Lactobacillus
fermentum) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		3 GLU A 331
HIS A 348
HIS A 447
 None
 0.60A 1oe2A-4lqlA:
undetectable		 1oe2A-4lqlA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mif PYRANOSE 2-OXIDASE

(Phanerochaete
chrysosporium) 		PF05199
(GMC_oxred_C) 		3 GLU A 254
HIS A 256
HIS A 245
 None
 0.59A 1oe2A-4mifA:
undetectable		 1oe2A-4mifA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		3 GLU A 473
HIS A 222
HIS A 224
 MG  A 601 ( 2.6A)
MG  A 601 ( 3.4A)
MG  A 601 ( 3.3A)
 0.68A 1oe2A-4nnbA:
undetectable		 1oe2A-4nnbA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		3 GLU A  25
HIS A  22
HIS A  21
 None
 0.64A 1oe2A-4nq1A:
undetectable		 1oe2A-4nq1A:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrn METAL-BOUND TOXIN

(Helicobacter
pylori) 		PF15738
(YafQ_toxin) 		3 GLU A  58
HIS A  60
HIS A  47
 ZN  A 102 ( 3.1A)
ZN  A 101 (-3.2A)
ZN  A 101 (-3.4A)
 0.51A 1oe2A-4nrnA:
undetectable		 1oe2A-4nrnA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		3 GLU A  29
HIS A  31
HIS A   4
 None
 0.69A 1oe2A-4pzkA:
undetectable		 1oe2A-4pzkA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0s L-RIBOSE ISOMERASE

(Acinetobacter
sp. DL-28) 		no annotation 3 GLU A 113
HIS A 188
HIS A 108
 CO  A 501 ( 2.4A)
CO  A 501 ( 3.5A)
CO  A 501 ( 3.3A)
 0.71A 1oe2A-4q0sA:
1.3		 1oe2A-4q0sA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		3 GLU A  48
HIS A 196
HIS A 198
 None
 0.62A 1oe2A-4qlbA:
undetectable		 1oe2A-4qlbA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnk IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00475
(IGPD) 		3 GLU A  77
HIS A  73
HIS A 145
 MN  A 302 (-2.8A)
MN  A 302 (-3.5A)
MN  A 302 (-3.5A)
 0.53A 1oe2A-4qnkA:
undetectable		 1oe2A-4qnkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnk IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00475
(IGPD) 		3 GLU A 173
HIS A 169
HIS A  47
 MN  A 301 (-2.7A)
MN  A 301 (-3.4A)
MN  A 301 (-3.5A)
 0.49A 1oe2A-4qnkA:
undetectable		 1oe2A-4qnkA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1p L-ARABINOSE
ISOMERASE

(Geobacillus
kaustophilus) 		PF02610
(Arabinose_Isome)
PF11762
(Arabinose_Iso_C) 		3 GLU A 332
HIS A 349
HIS A 448
 MN  A 501 (-2.7A)
MN  A 501 (-3.6A)
MN  A 501 (-3.4A)
 0.50A 1oe2A-4r1pA:
undetectable		 1oe2A-4r1pA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk6 QUINOLINATE SYNTHASE
A

(Pyrococcus
horikoshii) 		PF02445
(NadA) 		3 GLU A 198
HIS A 173
HIS A 196
 NTM  A 402 (-3.2A)
NTM  A 402 (-4.6A)
NTM  A 402 ( 3.7A)
 0.70A 1oe2A-4zk6A:
undetectable		 1oe2A-4zk6A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		3 GLU K 102
HIS K  96
HIS K 666
 None
 0.66A 1oe2A-5anbK:
undetectable		 1oe2A-5anbK:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 GLU A 189
HIS A   1
HIS A 193
 ZN  A1194 (-2.2A)
ZN  A1194 (-3.1A)
ZN  A1194 (-3.1A)
 0.69A 1oe2A-5aq6A:
undetectable		 1oe2A-5aq6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq6 METAL-BINDING
PROTEIN ZINT

(Escherichia
coli) 		PF09223
(ZinT) 		3 GLU A 189
HIS A 193
HIS A   6
 ZN  A1194 (-2.2A)
ZN  A1194 (-3.1A)
ZN  A1194 (-3.2A)
 0.63A 1oe2A-5aq6A:
undetectable		 1oe2A-5aq6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5avp L-RIBOSE ISOMERASE

(Geodermatophilus
obscurus) 		no annotation 3 GLU A 117
HIS A 192
HIS A 112
 MN  A 401 (-2.3A)
MN  A 401 (-3.5A)
MN  A 401 (-3.5A)
 0.66A 1oe2A-5avpA:
1.2		 1oe2A-5avpA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dnl IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Pyrococcus
furiosus) 		PF00475
(IGPD) 		3 GLU A 149
HIS A 145
HIS A  29
 None
 0.31A 1oe2A-5dnlA:
undetectable		 1oe2A-5dnlA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 GLU A 302
HIS A 299
HIS A 298
 None
 0.71A 1oe2A-5e0cA:
1.9		 1oe2A-5e0cA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flj QUERCETINASE QUED

(Streptomyces
sp. FLA) 		PF07883
(Cupin_2) 		3 GLU A  76
HIS A 115
HIS A  71
 NI  A 300 ( 2.3A)
NI  A 300 (-3.2A)
NI  A 300 ( 3.3A)
 0.60A 1oe2A-5fljA:
1.5		 1oe2A-5fljA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpr CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18)
PF08329
(ChitinaseA_N) 		3 GLU A 351
HIS A 377
HIS A 179
 GLU  A 351 ( 0.6A)
HIS  A 377 ( 1.0A)
HIS  A 179 ( 1.0A)
 0.70A 1oe2A-5gprA:
2.8		 1oe2A-5gprA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxu NADPH--CYTOCHROME
P450 REDUCTASE 2

(Arabidopsis
thaliana) 		PF00175
(NAD_binding_1)
PF00258
(Flavodoxin_1)
PF00667
(FAD_binding_1) 		3 GLU A 336
HIS A 334
HIS A 505
 None
 0.69A 1oe2A-5gxuA:
undetectable		 1oe2A-5gxuA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy5 CYTOCHROME C OXIDASE
SUBUNIT 3

(Bos taurus) 		PF00510
(COX3) 		3 GLU C 236
HIS C 232
HIS C 148
 NA  C 302 (-3.0A)
NA  C 302 (-3.4A)
NA  C 302 (-3.4A)
 0.46A 1oe2A-5iy5C:
undetectable		 1oe2A-5iy5C:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A  73
HIS A 107
HIS A  48
 ZN  A1001 ( 2.2A)
ZN  A1001 ( 3.1A)
ZN  A1003 ( 3.3A)
 0.69A 1oe2A-5lewA:
undetectable		 1oe2A-5lewA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nhk FERRIC UPTAKE
REGULATION PROTEIN

(Francisella
tularensis) 		no annotation 3 GLU A 101
HIS A  90
HIS A  88
 FE  A 201 (-3.1A)
FE  A 201 (-3.3A)
FE  A 201 (-3.4A)
 0.62A 1oe2A-5nhkA:
undetectable		 1oe2A-5nhkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 GLU E  24
HIS E  26
HIS E  27
 None
 0.72A 1oe2A-5uj7E:
undetectable		 1oe2A-5uj7E:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		3 GLU E  24
HIS E  26
HIS E  27
 None
 0.72A 1oe2A-5ujmE:
undetectable		 1oe2A-5ujmE:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 3 GLU A  12
HIS A 166
HIS A 168
 None
 0.65A 1oe2A-5vncA:
undetectable		 1oe2A-5vncA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 3 GLU Z  51
HIS Z 385
HIS Z  49
 None
G  B 107 ( 3.7A)
A  B 108 ( 4.9A)
 0.41A 1oe2A-5wtiZ:
undetectable		 1oe2A-5wtiZ:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zhz PROBABLE
ENDONUCLEASE 4

(Mycobacterium
tuberculosis) 		no annotation 3 GLU A 129
HIS A 165
HIS A  96
 ZN  A 304 (-2.3A)
ZN  A 306 ( 3.2A)
ZN  A 304 ( 3.1A)
 0.51A 1oe2A-5zhzA:
undetectable		 1oe2A-5zhzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 3 GLU A  34
HIS A  67
HIS A  69
 ZN  A 400 ( 2.3A)
TAR  A 401 ( 3.3A)
ZN  A 400 ( 3.3A)
 0.32A 1oe2A-5zmyA:
undetectable		 1oe2A-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6df3 -

(-) 		no annotation 3 GLU L 168
HIS L 166
HIS L 178
 None
 0.71A 1oe2A-6df3L:
1.7		 1oe2A-6df3L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Saccharomyces
cerevisiae) 		no annotation 3 GLU U  94
HIS U  90
HIS U 162
 MN  U 301 ( 2.4A)
MN  U 301 ( 3.2A)
MN  U 301 (-3.2A)
 0.55A 1oe2A-6ezmU:
undetectable		 1oe2A-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezm IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Saccharomyces
cerevisiae) 		no annotation 3 GLU U 190
HIS U 186
HIS U  64
 MN  U 302 ( 2.4A)
MN  U 302 ( 3.5A)
MN  U 302 ( 3.4A)
 0.35A 1oe2A-6ezmU:
undetectable		 1oe2A-6ezmU:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 3 GLU A  70
HIS A  66
HIS A 138
 MN  A 202 ( 2.7A)
MN  A 202 ( 3.4A)
MN  A 202 (-3.5A)
 0.42A 1oe2A-6fwhA:
undetectable		 1oe2A-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwh IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Acanthamoeba
castellanii) 		no annotation 3 GLU A 166
HIS A 162
HIS A  40
 MN  A 201 ( 2.6A)
MN  A 201 ( 3.5A)
MN  A 201 ( 3.5A)
 0.31A 1oe2A-6fwhA:
undetectable		 1oe2A-6fwhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g74 QUINOLINATE SYNTHASE
A

(Thermotoga
maritima) 		no annotation 3 GLU A 195
HIS A 171
HIS A 193
 PHT  A 302 ( 3.6A)
None
PHT  A 302 (-3.8A)
 0.68A 1oe2A-6g74A:
undetectable		 1oe2A-6g74A:
undetectable