SIMILAR PATTERNS OF AMINO ACIDS FOR 1OC3_A_BEZA201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME


(Pseudomonas
putida)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 THR A 355
PRO A 356
GLY A 357
THR A 361
None
0.69A 1oc3A-1bkhA:
2.1
1oc3A-1bkhA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1buc BUTYRYL-COA
DEHYDROGENASE


(Megasphaera
elsdenii)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 THR A 194
PRO A 195
GLY A 196
THR A 153
None
0.85A 1oc3A-1bucA:
undetectable
1oc3A-1bucA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA


(Pariacoto virus)
PF01829
(Peptidase_A6)
4 PRO A 112
GLY A 113
PHE A 261
THR A 285
None
0.80A 1oc3A-1f8vA:
undetectable
1oc3A-1f8vA:
22.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1h4o PEROXIREDOXIN 5

(Homo sapiens)
PF08534
(Redoxin)
8 PRO A  40
THR A  44
PRO A  45
GLY A  46
CYH A  47
PHE A 120
ARG A 127
THR A 147
BEZ  A1162 (-4.5A)
BEZ  A1162 (-4.0A)
BEZ  A1162 (-3.7A)
BEZ  A1162 (-3.1A)
BEZ  A1162 (-3.3A)
None
BEZ  A1162 (-3.7A)
BEZ  A1162 ( 4.0A)
0.18A 1oc3A-1h4oA:
35.0
1oc3A-1h4oA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hr7 MITOCHONDRIAL
PROCESSING PEPTIDASE
ALPHA SUBUNIT
MITOCHONDRIAL
PROCESSING PEPTIDASE
BETA SUBUNIT


(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
4 PRO B  43
THR A  35
PRO A  36
GLY A  37
None
0.72A 1oc3A-1hr7B:
undetectable
1oc3A-1hr7B:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k86 CASPASE-7

(Homo sapiens)
PF00656
(Peptidase_C14)
4 CYH A 186
PHE A  78
ARG A 233
THR A  90
None
0.71A 1oc3A-1k86A:
undetectable
1oc3A-1k86A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT


(Klebsiella
pneumoniae)
PF08841
(DDR)
4 THR A 404
PRO A 405
GLY A 406
CYH A 407
None
0.89A 1oc3A-1nbwA:
undetectable
1oc3A-1nbwA:
14.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nm3 PROTEIN HI0572

(Haemophilus
influenzae)
PF00462
(Glutaredoxin)
PF08534
(Redoxin)
6 PRO A  42
THR A  46
PRO A  47
CYH A  49
PHE A 120
ARG A 126
None
0.61A 1oc3A-1nm3A:
24.0
1oc3A-1nm3A:
31.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1


(Mycobacterium
tuberculosis)
PF12849
(PBP_like_2)
4 THR A 218
PRO A 219
GLY A 220
CYH A 221
None
0.73A 1oc3A-1pc3A:
undetectable
1oc3A-1pc3A:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1psq PROBABLE THIOL
PEROXIDASE


(Streptococcus
pneumoniae)
PF08534
(Redoxin)
4 PRO A  51
THR A  55
CYH A  58
ARG A 127
None
0.49A 1oc3A-1psqA:
19.6
1oc3A-1psqA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd1 FORMIMINOTRANSFERASE
-CYCLODEAMINASE


(Sus scrofa)
PF02971
(FTCD)
PF07837
(FTCD_N)
4 THR A  30
PRO A  31
GLY A  32
CYH A  33
None
0.32A 1oc3A-1qd1A:
undetectable
1oc3A-1qd1A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmv PEROXIREDOXIN-2

(Homo sapiens)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  44
THR A  48
CYH A  51
ARG A 127
None
0.53A 1oc3A-1qmvA:
18.4
1oc3A-1qmvA:
27.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkl COPROPORPHYRINOGEN
III OXIDASE


(Saccharomyces
cerevisiae)
PF01218
(Coprogen_oxidas)
4 THR A 283
PRO A 284
GLY A 285
ARG A  46
None
0.89A 1oc3A-1tklA:
undetectable
1oc3A-1tklA:
20.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tp9 PEROXIREDOXIN

(Populus
trichocarpa)
PF08534
(Redoxin)
5 PRO A  44
THR A  48
PRO A  49
CYH A  51
ARG A 129
None
SO4  A1248 ( 4.6A)
SO4  A1248 (-3.6A)
None
None
0.16A 1oc3A-1tp9A:
26.7
1oc3A-1tp9A:
40.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE


(Aeropyrum
pernix)
PF00793
(DAHP_synth_1)
4 THR A 259
PRO A 260
GLY A 261
ARG A 265
None
0.82A 1oc3A-1vs1A:
2.1
1oc3A-1vs1A:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y25 PROBABLE THIOL
PEROXIDASE


(Mycobacterium
tuberculosis)
PF08534
(Redoxin)
4 PRO A  53
THR A  57
PRO A  58
ARG A 130
None
ACT  A1200 (-3.6A)
ACT  A1200 (-3.6A)
ACT  A1200 (-3.1A)
0.53A 1oc3A-1y25A:
19.2
1oc3A-1y25A:
30.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykw RUBISCO-LIKE PROTEIN

(Chlorobaculum
tepidum)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
4 THR A 124
PRO A 125
GLY A 126
THR A  36
None
0.71A 1oc3A-1ykwA:
undetectable
1oc3A-1ykwA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z60 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX P44 SUBUNIT


(Homo sapiens)
PF07975
(C1_4)
4 PRO A 383
GLY A 384
CYH A 385
PHE A 331
None
ZN  A   2 ( 4.6A)
ZN  A   2 (-2.3A)
None
0.71A 1oc3A-1z60A:
undetectable
1oc3A-1z60A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zye THIOREDOXIN-DEPENDEN
T PEROXIDE REDUCTASE


(Bos taurus)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  40
THR A  44
CYH A  47
ARG A 123
None
0.72A 1oc3A-1zyeA:
19.0
1oc3A-1zyeA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4v PEROXIREDOXIN DOT5

(Saccharomyces
cerevisiae)
PF00578
(AhpC-TSA)
5 PRO A 100
THR A 104
PRO A 105
GLY A 106
ARG A 175
None
0.61A 1oc3A-2a4vA:
20.2
1oc3A-2a4vA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cc3 PROTEIN VIRB8

(Agrobacterium
tumefaciens)
PF04335
(VirB8)
4 THR A 169
PRO A 170
GLY A 171
ARG A 198
None
0.89A 1oc3A-2cc3A:
undetectable
1oc3A-2cc3A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx4 BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Aeropyrum
pernix)
PF00578
(AhpC-TSA)
4 PRO A  42
PRO A  47
CYH A  49
ARG A 122
None
0.36A 1oc3A-2cx4A:
20.9
1oc3A-2cx4A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2deo 441AA LONG
HYPOTHETICAL NFED
PROTEIN


(Pyrococcus
horikoshii)
PF00574
(CLP_protease)
4 THR A  62
PRO A  63
GLY A  64
THR A  34
None
0.88A 1oc3A-2deoA:
undetectable
1oc3A-2deoA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8x XENOBIOTIC REDUCTASE
A


(Pseudomonas
putida)
PF00724
(Oxidored_FMN)
4 THR A  67
PRO A  68
GLY A  69
CYH A  70
None
SO4  A1506 ( 4.7A)
None
None
0.88A 1oc3A-2h8xA:
undetectable
1oc3A-2h8xA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjp CYTOCHROME P450
113A1


(Saccharopolyspora
erythraea)
PF00067
(p450)
4 THR A  83
PRO A  84
GLY A  85
THR A 236
None
0.71A 1oc3A-2jjpA:
undetectable
1oc3A-2jjpA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jx1 MYELIN TRANSCRIPTION
FACTOR 1


(Mus musculus)
PF01530
(zf-C2HC)
4 THR A  14
PRO A  15
GLY A  16
CYH A  17
None
0.79A 1oc3A-2jx1A:
undetectable
1oc3A-2jx1A:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbe ATP-DEPENDENT RNA
HELICASE DBP5


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
4 PRO A 198
THR A 215
PRO A 216
GLY A 217
None
0.73A 1oc3A-2kbeA:
undetectable
1oc3A-2kbeA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lex PROBABLE WRKY
TRANSCRIPTION FACTOR
4


(Arabidopsis
thaliana)
PF03106
(WRKY)
4 THR A 436
PRO A 437
GLY A 438
CYH A 439
ZN  A 500 (-3.5A)
None
None
ZN  A 500 (-2.5A)
0.62A 1oc3A-2lexA:
undetectable
1oc3A-2lexA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf8 MYELIN TRANSCRIPTION
FACTOR 1


(Mus musculus)
PF01530
(zf-C2HC)
4 THR A 804
PRO A 805
GLY A 806
CYH A 807
ZN  A 901 (-4.0A)
None
None
ZN  A 901 (-1.9A)
0.87A 1oc3A-2mf8A:
undetectable
1oc3A-2mf8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf8 MYELIN TRANSCRIPTION
FACTOR 1


(Mus musculus)
PF01530
(zf-C2HC)
4 THR A 848
PRO A 849
GLY A 850
CYH A 851
ZN  A 902 (-3.2A)
None
None
ZN  A 902 (-2.3A)
0.89A 1oc3A-2mf8A:
undetectable
1oc3A-2mf8A:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2pwj MITOCHONDRIAL
PEROXIREDOXIN


(Pisum sativum)
PF08534
(Redoxin)
4 PRO A  52
THR A  56
CYH A  59
ARG A 137
None
0.52A 1oc3A-2pwjA:
26.2
1oc3A-2pwjA:
33.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 THR A 347
PRO A 348
GLY A 349
THR A 353
GOL  A 380 (-3.5A)
GOL  A 380 (-4.3A)
GOL  A 380 ( 3.9A)
GOL  A 380 (-4.1A)
0.62A 1oc3A-2rdxA:
2.2
1oc3A-2rdxA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v41 PEROXIREDOXIN 6.

(Arenicola
marina)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  38
THR A  42
PRO A  43
ARG A 128
BEZ  A1222 ( 4.6A)
BEZ  A1222 (-3.6A)
BEZ  A1222 (-3.2A)
BEZ  A1222 (-3.3A)
0.48A 1oc3A-2v41A:
18.3
1oc3A-2v41A:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vil VILLIN 14T

(Gallus gallus)
PF00626
(Gelsolin)
4 THR A  15
PRO A  16
GLY A  17
THR A  33
None
0.60A 1oc3A-2vilA:
undetectable
1oc3A-2vilA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxo GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Homo sapiens)
PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase)
4 PRO A 650
PRO A 687
GLY A 688
ARG A 638
None
0.76A 1oc3A-2vxoA:
undetectable
1oc3A-2vxoA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa)
PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc)
5 THR A1122
PRO A1123
GLY A1512
PHE A1517
THR A1232
None
1.36A 1oc3A-2vz9A:
undetectable
1oc3A-2vz9A:
6.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wfc PEROXIREDOXIN 5

(Arenicola
marina)
PF08534
(Redoxin)
5 PRO A  67
THR A  71
PRO A  72
GLY A  73
ARG A 152
None
0.59A 1oc3A-2wfcA:
31.5
1oc3A-2wfcA:
60.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykf PROBABLE SENSOR
HISTIDINE KINASE
PDTAS


(Mycobacterium
tuberculosis)
PF12282
(H_kinase_N)
4 PRO A 115
THR A  86
GLY A  90
ARG A 117
None
0.83A 1oc3A-2ykfA:
undetectable
1oc3A-2ykfA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzh PROBABLE THIOL
PEROXIDASE


(Aquifex
aeolicus)
PF08534
(Redoxin)
5 PRO A  54
THR A  58
PRO A  59
CYH A  61
ARG A 132
None
0.45A 1oc3A-2yzhA:
19.2
1oc3A-2yzhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzh PROBABLE THIOL
PEROXIDASE


(Aquifex
aeolicus)
PF08534
(Redoxin)
5 THR A  58
PRO A  59
CYH A  61
ARG A 132
THR A 153
None
0.71A 1oc3A-2yzhA:
19.2
1oc3A-2yzhA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5w PROBABLE
PEROXIREDOXIN


(Aeropyrum
pernix)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 PRO A  43
THR A  47
PRO A  48
CYH A  50
ARG A 126
None
0.51A 1oc3A-3a5wA:
16.3
1oc3A-3a5wA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt3 GLYOXALASE-RELATED
ENZYME, ARAC TYPE


(Lachnoclostridium
phytofermentans)
no annotation 5 THR A 252
GLY A 255
CYH A 256
PHE A 158
THR A 148
None
1.11A 1oc3A-3bt3A:
undetectable
1oc3A-3bt3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bzm MENAQUINONE-SPECIFIC
ISOCHORISMATE
SYNTHASE


(Escherichia
coli)
PF00425
(Chorismate_bind)
5 PRO A  20
THR A  22
PRO A  23
GLY A  24
ARG A  26
None
1.28A 1oc3A-3bzmA:
undetectable
1oc3A-3bzmA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE


(Mus musculus)
PF00004
(AAA)
PF09336
(Vps4_C)
4 PRO A 648
PRO A 520
GLY A 521
CYH A 522
None
ADP  A 900 ( 4.9A)
ADP  A 900 (-3.4A)
None
0.85A 1oc3A-3cf0A:
undetectable
1oc3A-3cf0A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3a BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
PF01301
(Glyco_hydro_35)
4 PRO A  55
GLY A 578
CYH A 579
PHE A 305
None
0.85A 1oc3A-3d3aA:
undetectable
1oc3A-3d3aA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drn PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG


(Sulfolobus
solfataricus)
PF00578
(AhpC-TSA)
5 PRO A  38
THR A  42
PRO A  43
GLY A  44
ARG A 112
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.6A)
CIT  A 500 (-2.9A)
CIT  A 500 (-3.7A)
0.39A 1oc3A-3drnA:
19.4
1oc3A-3drnA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9y ACETOLACTATE
SYNTHASE,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
4 PRO A 611
THR A 631
PRO A 632
GLY A 633
None
0.78A 1oc3A-3e9yA:
undetectable
1oc3A-3e9yA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ebv CHINITASE A

(Streptomyces
coelicolor)
PF00704
(Glyco_hydro_18)
4 THR A  43
PRO A  44
GLY A  45
THR A  98
None
0.56A 1oc3A-3ebvA:
undetectable
1oc3A-3ebvA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ei8 LL-DIAMINOPIMELATE
AMINOTRANSFERASE


(Arabidopsis
thaliana)
PF00155
(Aminotran_1_2)
4 THR A 390
PRO A 391
GLY A 392
PHE A  39
None
0.88A 1oc3A-3ei8A:
undetectable
1oc3A-3ei8A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsc QDTC

(Thermoanaerobacterium
thermosaccharolyticum)
PF00132
(Hexapep)
4 GLY A  32
CYH A  33
PHE A  46
THR A  81
None
0.88A 1oc3A-3fscA:
undetectable
1oc3A-3fscA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE


(Streptomyces
antibioticus)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 THR A 450
GLY A 452
PHE A 546
ARG A 496
None
0.81A 1oc3A-3gyrA:
undetectable
1oc3A-3gyrA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4i GLYCOSYLTRANSFERASE
GTFA,
GLYCOSYLTRANSFERASE


(Actinoplanes
teichomyceticus;
Amycolatopsis
orientalis)
PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C)
4 THR A 351
PRO A 352
GLY A 353
ARG A 357
None
0.75A 1oc3A-3h4iA:
2.3
1oc3A-3h4iA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III


(Ruegeria
pomeroyi)
PF00202
(Aminotran_3)
5 PRO A 229
THR A 270
GLY A 266
CYH A 265
THR A 276
None
1.34A 1oc3A-3hmuA:
undetectable
1oc3A-3hmuA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iuu PUTATIVE
METALLOPEPTIDASE


(Chelativorans
sp. BNC1)
PF07171
(MlrC_C)
PF07364
(DUF1485)
4 THR A  23
GLY A  73
PHE A  28
THR A 107
None
0.87A 1oc3A-3iuuA:
undetectable
1oc3A-3iuuA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ixr BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Xylella
fastidiosa)
PF00578
(AhpC-TSA)
5 PRO A  40
THR A  44
PRO A  45
GLY A  46
ARG A 122
None
0.47A 1oc3A-3ixrA:
18.8
1oc3A-3ixrA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfq HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA


(Streptococcus
suis)
PF01297
(ZnuA)
4 PRO A  67
THR A 248
GLY A  64
THR A  40
None
0.85A 1oc3A-3mfqA:
undetectable
1oc3A-3mfqA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0a TYROSINE-PROTEIN
PHOSPHATASE AUXILIN


(Bos taurus)
PF10409
(PTEN_C2)
4 THR A 184
PRO A 185
GLY A 186
ARG A 190
None
0.86A 1oc3A-3n0aA:
undetectable
1oc3A-3n0aA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7x PROBABLE THIOL
PEROXIDASE


(Staphylococcus
aureus)
PF08534
(Redoxin)
4 PRO A  53
THR A  57
CYH A  60
ARG A 128
None
0.48A 1oc3A-3p7xA:
18.8
1oc3A-3p7xA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p7x PROBABLE THIOL
PEROXIDASE


(Staphylococcus
aureus)
PF08534
(Redoxin)
4 THR A  57
CYH A  60
ARG A 128
THR A 149
None
0.62A 1oc3A-3p7xA:
18.8
1oc3A-3p7xA:
27.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpm PEROXIREDOXIN

(Larimichthys
crocea)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A 106
THR A 110
CYH A 113
ARG A 189
None
0.58A 1oc3A-3qpmA:
16.7
1oc3A-3qpmA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tb2 1-CYS PEROXIREDOXIN

(Plasmodium
yoelii)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
5 PRO A  40
THR A  44
PRO A  45
CYH A  47
ARG A 129
GOL  A 223 (-4.3A)
GOL  A 223 ( 4.3A)
GOL  A 223 (-3.6A)
GOL  A 223 (-4.4A)
GOL  A 223 (-4.1A)
0.56A 1oc3A-3tb2A:
17.4
1oc3A-3tb2A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkr PEROXIREDOXIN-4

(Homo sapiens)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  80
THR A  84
CYH A  87
ARG A 163
None
0.58A 1oc3A-3tkrA:
18.7
1oc3A-3tkrA:
27.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN


(Sinorhizobium
meliloti)
PF08534
(Redoxin)
5 PRO A  42
THR A  46
PRO A  47
CYH A  49
ARG A 127
None
0.17A 1oc3A-3umaA:
27.3
1oc3A-3umaA:
40.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zre THIOL PEROXIDASE

(Yersinia
pseudotuberculosis)
PF08534
(Redoxin)
4 PRO A  54
THR A  58
CYH A  61
ARG A 133
None
0.51A 1oc3A-3zreA:
18.2
1oc3A-3zreA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zse ENDO-1,4-BETA-XYLANA
SE


(Thermobifida
fusca)
PF00457
(Glyco_hydro_11)
4 THR A 149
GLY A 151
ARG A 184
THR A 188
None
0.84A 1oc3A-3zseA:
undetectable
1oc3A-3zseA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chl PERSULFIDE
DIOXYGENASE ETHE1,
MITOCHONDRIAL


(Homo sapiens)
PF00753
(Lactamase_B)
4 THR A 136
PRO A 137
GLY A 138
CYH A 139
None
0.84A 1oc3A-4chlA:
undetectable
1oc3A-4chlA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7l PEPTIDE METHIONINE
SULFOXIDE REDUCTASE
MSRA


(Corynebacterium
diphtheriae)
PF01625
(PMSR)
4 THR A  63
PRO A  64
GLY A  65
THR A 107
None
0.54A 1oc3A-4d7lA:
undetectable
1oc3A-4d7lA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d82 AAA ATPASE, CENTRAL
DOMAIN PROTEIN


(Metallosphaera
sedula)
PF00004
(AAA)
PF09336
(Vps4_C)
4 PRO A 270
PRO A 140
GLY A 141
CYH A 142
None
None
ADP  A1367 (-3.2A)
None
0.85A 1oc3A-4d82A:
undetectable
1oc3A-4d82A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eo3 BACTERIOFERRITIN
COMIGRATORY
PROTEIN/NADH
DEHYDROGENASE


(Thermotoga
maritima)
PF00578
(AhpC-TSA)
PF00881
(Nitroreductase)
4 PRO A  33
THR A  37
GLY A  39
ARG A 103
None
SO4  A 402 (-3.4A)
SO4  A 402 (-3.3A)
SO4  A 402 (-3.5A)
0.46A 1oc3A-4eo3A:
17.8
1oc3A-4eo3A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f82 THIOREDOXIN
REDUCTASE


(Burkholderia
cenocepacia)
PF08534
(Redoxin)
5 PRO A  48
THR A  52
PRO A  53
CYH A  55
ARG A 133
None
0.22A 1oc3A-4f82A:
27.7
1oc3A-4f82A:
43.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4frz KINESIN-LIKE
CALMODULIN-BINDING
PROTEIN


(Arabidopsis
thaliana)
PF00225
(Kinesin)
4 THR A 990
PRO A 991
GLY A 988
THR A 977
None
None
None
MG  A1301 ( 3.1A)
0.88A 1oc3A-4frzA:
undetectable
1oc3A-4frzA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria)
PF00962
(A_deaminase)
4 PRO A   9
THR A   4
PRO A   5
GLY A   6
None
0.80A 1oc3A-4gxwA:
undetectable
1oc3A-4gxwA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1f TRYPAREDOXIN
PEROXIDASE


(Leishmania
major)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  45
THR A  49
CYH A  52
ARG A 128
None
PGE  A 201 ( 4.1A)
None
None
0.51A 1oc3A-4k1fA:
17.2
1oc3A-4k1fA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgm VPS4 AAA ATPASE

(Sulfolobus
solfataricus)
PF00004
(AAA)
PF09336
(Vps4_C)
4 PRO A 273
PRO A 143
GLY A 144
CYH A 145
None
None
CL  A 401 ( 4.4A)
None
0.75A 1oc3A-4lgmA:
undetectable
1oc3A-4lgmA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4llr TRYPAREDOXIN
PEROXIDASE


(Trypanosoma
cruzi)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  45
THR A  49
CYH A  52
ARG A 128
None
0.49A 1oc3A-4llrA:
17.2
1oc3A-4llrA:
25.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D


(Vibrio
cholerae;
Vibrio cholerae)
PF04205
(FMN_bind)
PF02508
(Rnf-Nqr)
4 THR C 173
PRO C 174
GLY C 175
THR D  35
FMN  C 301 (-3.2A)
None
None
None
0.80A 1oc3A-4p6vC:
undetectable
1oc3A-4p6vC:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qbj GLYCYLPEPTIDE
N-TETRADECANOYLTRANS
FERASE


(Aspergillus
fumigatus)
PF01233
(NMT)
PF02799
(NMT_C)
4 THR A 302
PRO A 303
GLY A 304
THR A 368
None
0.69A 1oc3A-4qbjA:
undetectable
1oc3A-4qbjA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rul DNA TOPOISOMERASE 1

(Escherichia
coli)
PF01131
(Topoisom_bac)
PF01396
(zf-C4_Topoisom)
PF01751
(Toprim)
PF08272
(Topo_Zn_Ribbon)
4 THR A 667
GLY A 684
CYH A 683
THR A 688
None
None
ZN  A1002 (-2.3A)
None
0.88A 1oc3A-4rulA:
undetectable
1oc3A-4rulA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c04 PUTATIVE
PEROXIREDOXIN MT2298


(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
4 PRO A  38
THR A  42
CYH A  45
ARG A 116
None
0.50A 1oc3A-5c04A:
19.5
1oc3A-5c04A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cg0 BETA-GLUCOSIDASE

(Spodoptera
frugiperda)
PF00232
(Glyco_hydro_1)
4 THR A 184
GLY A 243
CYH A 242
THR A 322
None
0.78A 1oc3A-5cg0A:
undetectable
1oc3A-5cg0A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
4 PRO A 198
THR A 215
PRO A 216
GLY A 217
U  B   5 ( 4.3A)
U  B   5 ( 3.5A)
U  B   4 ( 3.8A)
U  B   5 ( 3.3A)
0.61A 1oc3A-5elxA:
undetectable
1oc3A-5elxA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5enu ALKYL HYDROPEROXIDE
REDUCTASE/ THIOL
SPECIFIC
ANTIOXIDANT/ MAL
ALLERGEN


(Burkholderia
ambifaria)
PF00578
(AhpC-TSA)
6 PRO A  37
THR A  41
PRO A  42
GLY A  43
CYH A  44
ARG A 119
None
0.35A 1oc3A-5enuA:
18.8
1oc3A-5enuA:
27.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5epf PEROXIREDOXIN

(Mycobacterium
tuberculosis)
PF00578
(AhpC-TSA)
6 PRO A  45
THR A  49
PRO A  50
GLY A  51
CYH A  52
ARG A 124
None
0.94A 1oc3A-5epfA:
20.9
1oc3A-5epfA:
30.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqt PROTEASOME-ACTIVATIN
G NUCLEOTIDASE


(Pyrococcus
horikoshii)
PF00004
(AAA)
4 PRO A 277
PRO A 149
GLY A 150
CYH A 151
None
ACT  A 402 ( 3.6A)
ADP  A 401 (-3.1A)
None
0.82A 1oc3A-5eqtA:
undetectable
1oc3A-5eqtA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0g GLUTATHIONE
S-TRANSFERASE D2


(Drosophila
melanogaster)
PF00043
(GST_C)
PF02798
(GST_N)
4 THR A 190
PRO A 191
GLY A 192
THR A  14
None
0.68A 1oc3A-5f0gA:
undetectable
1oc3A-5f0gA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7d PUTRESCINE
AMINOTRANSFERASE,IMM
UNOGLOBULIN
G-BINDING PROTEIN A


(Escherichia
coli;
Staphylococcus
aureus)
PF00202
(Aminotran_3)
PF02216
(B)
4 THR A 137
PRO A 138
GLY A 139
THR A 315
None
0.77A 1oc3A-5h7dA:
undetectable
1oc3A-5h7dA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipg BACTERIOFERRITIN
COMIGRATORY PROTEIN


(Xanthomonas
campestris)
PF00578
(AhpC-TSA)
6 PRO A  41
THR A  45
PRO A  46
GLY A  47
CYH A  48
ARG A 123
None
0.67A 1oc3A-5ipgA:
18.0
1oc3A-5ipgA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcg THIOREDOXIN-DEPENDEN
T PEROXIDE
REDUCTASE,
MITOCHONDRIAL


(Homo sapiens)
PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C)
4 PRO A  40
THR A  44
CYH A  47
ARG A 123
None
0.54A 1oc3A-5jcgA:
17.4
1oc3A-5jcgA:
26.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jg7 FUR REGULATED
SALMONELLA IRON
TRANSPORTER


(Salmonella
enterica)
PF01297
(ZnuA)
4 THR A  69
PRO A  70
GLY A  71
ARG A  75
None
0.83A 1oc3A-5jg7A:
undetectable
1oc3A-5jg7A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jta NEUTRAL TREHALASE

(Saccharomyces
cerevisiae)
no annotation 5 PRO A 271
THR A 217
PRO A 218
GLY A 219
ARG A 224
None
1.50A 1oc3A-5jtaA:
undetectable
1oc3A-5jtaA:
14.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5k1g 1-CYS PEROXIREDOXIN

(Vibrio
vulnificus)
PF08534
(Redoxin)
5 PRO A  41
THR A  45
PRO A  46
PHE A 117
ARG A 124
None
0.89A 1oc3A-5k1gA:
27.7
1oc3A-5k1gA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kwa PROTEASOME-ASSOCIATE
D ATPASE


(Mycobacterium
tuberculosis)
PF00004
(AAA)
PF16450
(Prot_ATP_ID_OB)
4 PRO A 440
PRO A 295
GLY A 296
CYH A 297
None
ADP  A 701 (-4.9A)
ADP  A 701 (-3.3A)
None
0.88A 1oc3A-5kwaA:
undetectable
1oc3A-5kwaA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
4 THR A 452
PRO A 453
GLY A 454
ARG A 458
EDO  A 504 ( 4.8A)
None
EDO  A 504 ( 3.9A)
EDO  A 504 (-3.1A)
0.84A 1oc3A-5lxdA:
undetectable
1oc3A-5lxdA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride)
no annotation 4 PRO A 382
THR A 389
PRO A 390
GLY A 391
None
None
GOL  A 609 ( 4.8A)
GOL  A 609 (-4.0A)
0.86A 1oc3A-5o5dA:
undetectable
1oc3A-5o5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc1 MATURATION PROTEIN

(Escherichia
virus MS2)
PF03863
(Phage_mat-A)
4 THR M  40
PRO M  41
GLY M  42
PHE M   4
None
None
None
U  R3553 ( 3.8A)
0.80A 1oc3A-5tc1M:
undetectable
1oc3A-5tc1M:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX


(Lassa
mammarenavirus)
PF00798
(Arena_glycoprot)
4 THR a 274
PRO a 275
GLY a 276
THR a 296
None
0.78A 1oc3A-5vk2a:
undetectable
1oc3A-5vk2a:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbq PEROXIREDOXIN

(Pyrococcus
horikoshii)
no annotation 4 PRO A  39
THR A  43
PRO A  44
ARG A 121
OCS  A  46 ( 3.3A)
OCS  A  46 ( 3.6A)
None
OCS  A  46 ( 2.3A)
0.52A 1oc3A-5xbqA:
18.0
1oc3A-5xbqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus)
no annotation 4 THR A 345
PRO A 346
GLY A 347
THR A 313
None
0.74A 1oc3A-6aunA:
undetectable
1oc3A-6aunA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eon BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron)
no annotation 4 PRO A  55
GLY A 578
CYH A 579
PHE A 305
None
0.81A 1oc3A-6eonA:
undetectable
1oc3A-6eonA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gww PEROXIREDOXIN

(Sulfolobus
islandicus)
no annotation 4 PRO A  42
THR A  46
PRO A  47
ARG A 125
CSO  A  49 ( 4.0A)
CSO  A  49 ( 3.3A)
None
CSO  A  49 ( 3.1A)
0.52A 1oc3A-6gwwA:
18.2
1oc3A-6gwwA:
undetectable