SIMILAR PATTERNS OF AMINO ACIDS FOR 1O86_A_LPRA702_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9r PROTEIN
(TERPREDOXIN)

(Pseudomonas sp.) 		PF00111
(Fer2) 		4 SER A  22
VAL A  60
PHE A   5
VAL A  15
 None
 1.10A 1o86A-1b9rA:
undetectable		 1o86A-1b9rA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		4 SER A 158
VAL A  92
PHE A 128
VAL A 132
 None
 1.49A 1o86A-1dj2A:
0.0		 1o86A-1dj2A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkd GROEL

(Escherichia
coli) 		PF00118
(Cpn60_TCP1) 		4 SER A 217
VAL A 323
PHE A 219
VAL A 240
 None
 1.43A 1o86A-1dkdA:
undetectable		 1o86A-1dkdA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 SER A 146
VAL A 129
PHE A 161
VAL A 165
 None
 1.39A 1o86A-1fi4A:
0.3		 1o86A-1fi4A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))

(Homo sapiens) 		PF01336
(tRNA_anti-codon)
PF16900
(REPA_OB_2) 		4 SER A 207
VAL A 203
PHE A 246
VAL A 242
 None
 1.49A 1o86A-1jmcA:
undetectable		 1o86A-1jmcA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 SER A 422
VAL A 431
PHE A 418
VAL A 460
 None
 1.34A 1o86A-1jmyA:
0.0		 1o86A-1jmyA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9x M32 CARBOXYPEPTIDASE

(Pyrococcus
furiosus) 		PF02074
(Peptidase_M32) 		4 SER A 140
VAL A 374
PHE A 104
VAL A 108
 None
 1.49A 1o86A-1k9xA:
20.7		 1o86A-1k9xA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdz ENOLASE

(Homarus
gammarus) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 114
VAL A  21
PHE A 381
VAL A 345
 None
 1.37A 1o86A-1pdzA:
0.0		 1o86A-1pdzA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suw PROBABLE INORGANIC
POLYPHOSPHATE/ATP-NA
D KINASE

(Archaeoglobus
fulgidus) 		PF01513
(NAD_kinase) 		4 SER A 106
VAL A 111
PHE A 216
VAL A 199
 None
 1.48A 1o86A-1suwA:
0.8		 1o86A-1suwA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usc PUTATIVE STYRENE
MONOOXYGENASE SMALL
COMPONENT

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 SER A  71
VAL A  52
PHE A  34
VAL A  32
 None
 1.35A 1o86A-1uscA:
undetectable		 1o86A-1uscA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vi1 FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Bacillus
subtilis) 		PF02504
(FA_synthesis) 		4 SER A 162
VAL A 173
PHE A 285
VAL A 318
 None
 1.48A 1o86A-1vi1A:
undetectable		 1o86A-1vi1A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1we5 PUTATIVE FAMILY 31
GLUCOSIDASE YICI

(Escherichia
coli) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 SER A 132
VAL A 228
PHE A 122
VAL A  67
 None
 1.50A 1o86A-1we5A:
undetectable		 1o86A-1we5A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 SER A  41
VAL A  84
PHE A 137
VAL A 165
 None
 1.14A 1o86A-1wekA:
undetectable		 1o86A-1wekA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y63 LMAJ004144AAA
PROTEIN

(Leishmania
major) 		PF13238
(AAA_18) 		4 SER A  92
VAL A 106
PHE A  96
VAL A  42
 None
 1.36A 1o86A-1y63A:
undetectable		 1o86A-1y63A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akz GAMMA ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 114
VAL A  21
PHE A 379
VAL A 343
 None
 1.41A 1o86A-2akzA:
undetectable		 1o86A-2akzA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bs9 BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF01229
(Glyco_hydro_39) 		4 SER A 226
VAL A 260
PHE A 211
VAL A 222
 None
 0.98A 1o86A-2bs9A:
undetectable		 1o86A-2bs9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 SER A1134
VAL A1149
PHE A1172
VAL A1086
 None
 1.44A 1o86A-2bzlA:
undetectable		 1o86A-2bzlA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gtt NUCLEOPROTEIN

(Rabies
lyssavirus) 		PF00945
(Rhabdo_ncap) 		4 SER A 146
VAL A 230
PHE A 203
VAL A  70
 None
A  W  48 ( 4.3A)
None
None
 1.10A 1o86A-2gttA:
undetectable		 1o86A-2gttA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ong 4S-LIMONENE SYNTHASE

(Mentha spicata) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 SER A 419
VAL A 344
PHE A 464
VAL A 412
 None
 1.44A 1o86A-2ongA:
undetectable		 1o86A-2ongA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9t DING

(Pseudomonas
fluorescens) 		PF12849
(PBP_like_2) 		4 SER A  89
VAL A 344
PHE A 313
VAL A  19
 None
 1.39A 1o86A-2q9tA:
undetectable		 1o86A-2q9tA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqu BETA-FRUCTOFURANOSID
ASE

(Arabidopsis
thaliana) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 SER A 478
VAL A 527
PHE A 431
VAL A 445
 None
 1.32A 1o86A-2qquA:
undetectable		 1o86A-2qquA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2var FRUCTOKINASE

(Sulfolobus
solfataricus) 		PF00294
(PfkB) 		4 SER A 160
VAL A 149
PHE A  39
VAL A  43
 None
 1.40A 1o86A-2varA:
1.7		 1o86A-2varA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2weu TRYPTOPHAN
5-HALOGENASE

(Streptomyces
rugosporus) 		PF04820
(Trp_halogenase) 		4 SER A 355
VAL A  52
PHE A 451
VAL A 396
 TRP  A1512 ( 4.8A)
None
TRP  A1512 ( 4.7A)
None
 1.37A 1o86A-2weuA:
undetectable		 1o86A-2weuA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsx L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER

(Escherichia
coli) 		PF02028
(BCCT) 		4 SER A 109
VAL A 104
PHE A 411
VAL A 273
 None
 1.45A 1o86A-2wsxA:
2.6		 1o86A-2wsxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsx BETA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 115
VAL A  22
PHE A 380
VAL A 344
 None
 1.34A 1o86A-2xsxA:
undetectable		 1o86A-2xsxA:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		4 SER A 355
VAL A 380
PHE A 512
VAL A 518
 3ES  A1636 (-4.3A)
3ES  A1635 (-3.9A)
3ES  A1635 (-4.8A)
3ES  A1636 (-4.1A)
 0.15A 1o86A-2xy9A:
62.6		 1o86A-2xy9A:
99.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 SER A 594
VAL A 512
PHE A 523
VAL A 545
 None
 1.33A 1o86A-2zwsA:
undetectable		 1o86A-2zwsA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b97 ALPHA-ENOLASE

(Homo sapiens) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 114
VAL A  21
PHE A 379
VAL A 343
 None
 1.41A 1o86A-3b97A:
undetectable		 1o86A-3b97A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehk PRUNIN

(Prunus dulcis) 		PF00190
(Cupin_1) 		4 SER A 417
VAL A  48
PHE A 449
VAL A 430
 None
 0.86A 1o86A-3ehkA:
undetectable		 1o86A-3ehkA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwe 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE III

(Burkholderia
pseudomallei) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 SER A 122
VAL A 303
PHE A 242
VAL A 247
 None
 1.22A 1o86A-3gweA:
undetectable		 1o86A-3gweA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hja GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Borreliella
burgdorferi) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 SER A 261
VAL A 297
PHE A 169
VAL A 254
 None
 1.24A 1o86A-3hjaA:
undetectable		 1o86A-3hjaA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn7 UDP-N-ACETYLMURAMATE
-L-ALANINE LIGASE

(Psychrobacter
arcticus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 SER A 157
VAL A 152
PHE A 175
VAL A  99
 None
 1.28A 1o86A-3hn7A:
undetectable		 1o86A-3hn7A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsk ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Candida
albicans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A 106
VAL A 120
PHE A  19
VAL A  15
 None
 1.42A 1o86A-3hskA:
undetectable		 1o86A-3hskA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kny HYPOTHETICAL PROTEIN
BT_3535

(Bacteroides
thetaiotaomicron) 		no annotation 4 SER A 210
VAL A  26
PHE A 190
VAL A 177
 None
 1.34A 1o86A-3knyA:
undetectable		 1o86A-3knyA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv4 PHD FINGER PROTEIN 8

(Homo sapiens) 		PF00628
(PHD)
PF02373
(JmjC) 		4 SER A 192
VAL A 231
PHE A 359
VAL A  16
 None
 1.18A 1o86A-3kv4A:
4.1		 1o86A-3kv4A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my7 ALCOHOL
DEHYDROGENASE/ACETAL
DEHYDE DEHYDROGENASE

(Vibrio
parahaemolyticus) 		PF00171
(Aldedh) 		4 SER A 127
VAL A 104
PHE A  23
VAL A  31
 None
 1.42A 1o86A-3my7A:
2.0		 1o86A-3my7A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 120
VAL A  23
PHE A 392
VAL A 356
 None
 1.26A 1o86A-3otrA:
undetectable		 1o86A-3otrA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qdq 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Clostridium
aminobutyricum) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 SER A 124
VAL A 121
PHE A 167
VAL A 162
 None
 1.34A 1o86A-3qdqA:
undetectable		 1o86A-3qdqA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtp ENOLASE 1

(Entamoeba
histolytica) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 113
VAL A  22
PHE A 384
VAL A 348
 None
 1.43A 1o86A-3qtpA:
undetectable		 1o86A-3qtpA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 SER A 375
VAL A 334
PHE A 371
VAL A 212
 None
 1.40A 1o86A-3rd8A:
3.2		 1o86A-3rd8A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN

(Murine leukemia
virus) 		PF00077
(RVP) 		4 SER A  38
VAL A  85
PHE A  29
VAL A  22
 None
 1.35A 1o86A-3slzA:
undetectable		 1o86A-3slzA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vpc PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Sulfurisphaera
tokodaii) 		PF08443
(RimK) 		4 SER A 235
VAL A 222
PHE A 233
VAL A 268
 None
 1.47A 1o86A-3vpcA:
undetectable		 1o86A-3vpcA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9v PHOSPHATE-BINDING
PROTEIN

(unidentified
prokaryotic
organism) 		PF12849
(PBP_like_2) 		4 SER A  88
VAL A 350
PHE A 319
VAL A  19
 None
 1.44A 1o86A-3w9vA:
undetectable		 1o86A-3w9vA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhe PROTEIN SMG-7

(Caenorhabditis
elegans) 		PF10373
(EST1_DNA_bind) 		4 SER B 265
VAL B 284
PHE B 208
VAL B 184
 None
 1.19A 1o86A-3zheB:
undetectable		 1o86A-3zheB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF03464
(eRF1_2)
PF03465
(eRF1_3) 		4 SER X 268
VAL X 275
PHE X 145
VAL X 158
 None
 1.46A 1o86A-4crmX:
undetectable		 1o86A-4crmX:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqn PUTATIVE
BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE
ILVE

(Streptococcus
mutans) 		PF01063
(Aminotran_4) 		4 SER A 290
VAL A 310
PHE A 166
VAL A 221
 None
 1.43A 1o86A-4dqnA:
undetectable		 1o86A-4dqnA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 SER A1016
VAL A1075
PHE A1031
VAL A1010
 None
None
PTR  A1008 ( 4.7A)
PTR  A1008 ( 4.1A)
 1.45A 1o86A-4gl9A:
undetectable		 1o86A-4gl9A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF01403
(Sema)
PF01437
(PSI) 		4 SER B 443
VAL B 345
PHE B 462
VAL B 504
 None
 1.14A 1o86A-4k3jB:
undetectable		 1o86A-4k3jB:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		4 SER B  90
VAL B 144
PHE B 224
VAL B 244
 PYC  B 904 (-3.1A)
None
PYC  B 904 ( 4.8A)
None
 1.17A 1o86A-4k7gB:
undetectable		 1o86A-4k7gB:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		4 SER A 413
VAL A 481
PHE A 388
VAL A 444
 None
 1.19A 1o86A-4n49A:
undetectable		 1o86A-4n49A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ohn ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF00497
(SBP_bac_3) 		4 SER A 107
VAL A 231
PHE A  49
VAL A 202
 HIS  A 301 (-2.2A)
None
HIS  A 301 (-3.4A)
None
 1.13A 1o86A-4ohnA:
undetectable		 1o86A-4ohnA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb7 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF13149
(Mfa_like_1) 		4 SER A 273
VAL A 196
PHE A 209
VAL A 314
 None
 1.48A 1o86A-4qb7A:
undetectable		 1o86A-4qb7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1n 3-HYDROXYBUTYRYL-COA
DEHYDROGENASE

(Clostridium
butyricum) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 SER A 169
VAL A 177
PHE A 139
VAL A  85
 None
 1.48A 1o86A-4r1nA:
undetectable		 1o86A-4r1nA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w5u CHITINASE

(Streptomyces
thermoviolaceus) 		no annotation 4 SER B 138
VAL B 216
PHE B 148
VAL B  81
 None
 1.45A 1o86A-4w5uB:
undetectable		 1o86A-4w5uB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yog 3C-LIKE PROTEINASE

(Tylonycteris
bat coronavirus
HKU4) 		PF05409
(Peptidase_C30) 		4 SER A 150
VAL A  13
PHE A 129
VAL A 131
 None
 1.34A 1o86A-4yogA:
undetectable		 1o86A-4yogA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg7 ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2

(Homo sapiens) 		PF01033
(Somatomedin_B)
PF01223
(Endonuclease_NS)
PF01663
(Phosphodiest) 		4 SER A 735
VAL A 703
PHE A 716
VAL A 721
 None
 1.44A 1o86A-4zg7A:
undetectable		 1o86A-4zg7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eef HDAC6

(Danio rerio) 		PF00850
(Hist_deacetyl) 		4 SER A 185
VAL A 108
PHE A  71
VAL A  89
 None
 1.49A 1o86A-5eefA:
undetectable		 1o86A-5eefA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 SER A 611
VAL A 607
PHE A 690
VAL A 158
 C2E  A 919 (-3.5A)
None
None
None
 1.21A 1o86A-5ej1A:
3.9		 1o86A-5ej1A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG

(Mus musculus) 		PF09822
(ABC_transp_aux) 		4 SER A 216
VAL A 213
PHE A  95
VAL A  18
 None
 0.97A 1o86A-5fmsA:
undetectable		 1o86A-5fmsA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 SER A 204
VAL A 406
PHE A 286
VAL A 128
 None
 1.38A 1o86A-5fv4A:
undetectable		 1o86A-5fv4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5y NON-LEE ENCODED
EFFECTOR PROTEIN
NLEB

(Escherichia
coli) 		no annotation 4 SER A 237
VAL A 240
PHE A 306
VAL A  24
 None
 1.46A 1o86A-5h5yA:
2.1		 1o86A-5h5yA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASC
CRISPR SYSTEM
CASCADE SUBUNIT CASE

(Escherichia
coli) 		PF08798
(CRISPR_assoc)
PF09344
(Cas_CT1975) 		4 SER D  14
VAL D 223
PHE D 219
VAL K 166
 None
 1.33A 1o86A-5h9fD:
undetectable		 1o86A-5h9fD:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5icq METHYLOCYSTIS PARVUS
OBBP MBNE

(Methylocystis
parvus) 		PF00496
(SBP_bac_5) 		4 SER A 465
VAL A 473
PHE A 346
VAL A 351
 None
 1.48A 1o86A-5icqA:
undetectable		 1o86A-5icqA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		PF00106
(adh_short) 		4 SER A 143
VAL A 163
PHE A  18
VAL A 237
 ACT  A 302 ( 2.7A)
None
NAD  A 301 (-4.1A)
None
 1.13A 1o86A-5ig2A:
undetectable		 1o86A-5ig2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 SER A  82
VAL A  85
PHE A 348
VAL A 340
 None
 1.34A 1o86A-5iq0A:
undetectable		 1o86A-5iq0A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8k UDP-2,3-DIACYLGLUCOS
AMINE HYDROLASE

(Haemophilus
influenzae) 		PF00149
(Metallophos) 		4 SER A  13
VAL A  60
PHE A  46
VAL A 151
 ACT  A 304 ( 3.8A)
None
ACT  A 304 ( 4.2A)
None
 1.49A 1o86A-5k8kA:
undetectable		 1o86A-5k8kA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 SER A 200
VAL A 262
PHE A 115
VAL A 167
 None
 1.25A 1o86A-5mifA:
undetectable		 1o86A-5mifA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n1t COPC

(Thioalkalivibrio
paradoxus) 		no annotation 4 SER M  35
VAL M  64
PHE M  26
VAL M  87
 None
 1.40A 1o86A-5n1tM:
undetectable		 1o86A-5n1tM:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u47 PENICILLIN BINDING
PROTEIN 2X

(Streptococcus
thermophilus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
PF03793
(PASTA) 		4 SER A 577
VAL A 610
PHE A 471
VAL A 347
 None
 1.17A 1o86A-5u47A:
undetectable		 1o86A-5u47A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		4 SER A 238
VAL A  16
PHE A 267
VAL A 314
 None
 1.45A 1o86A-5u4hA:
undetectable		 1o86A-5u4hA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqr 2-METHYLCITRATE
SYNTHASE,
MITOCHONDRIAL

(Aspergillus
fumigatus) 		no annotation 4 SER A 387
VAL A 332
PHE A 380
VAL A 413
 None
 1.39A 1o86A-5uqrA:
2.2		 1o86A-5uqrA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vjj AVIRULENCE PROTEIN
AVRP123

(Melampsora lini) 		no annotation 4 SER A  85
VAL A  34
PHE A  49
VAL A  51
 None
 0.97A 1o86A-5vjjA:
undetectable		 1o86A-5vjjA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 SER A 182
VAL A  89
PHE A 448
VAL A 412
 None
 1.46A 1o86A-5wroA:
undetectable		 1o86A-5wroA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bv2 AMINOPEPTIDASE N

(Sus scrofa) 		no annotation 4 SER A 585
VAL A 617
PHE A 627
VAL A 582
 None
 1.44A 1o86A-6bv2A:
6.7		 1o86A-6bv2A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fpd PROTEIN AB21

(Agaricus
bisporus) 		no annotation 4 SER A 145
VAL A  97
PHE A   9
VAL A 183
 None
None
NA  A 301 (-4.4A)
None
 1.47A 1o86A-6fpdA:
5.6		 1o86A-6fpdA:
8.61