SIMILAR PATTERNS OF AMINO ACIDS FOR 1O76_A_CAMA1420_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fx2 RECEPTOR-TYPE
ADENYLATE CYCLASE
GRESAG 4.1

(Trypanosoma
brucei) 		PF00211
(Guanylate_cyc) 		5 THR A 905
LEU A 935
VAL A 932
VAL A1063
VAL A1023
 None
 1.50A 1o76A-1fx2A:
0.0		 1o76A-1fx2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ijq LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00058
(Ldl_recept_b)
PF14670
(FXa_inhibition) 		5 THR A 413
LEU A 380
VAL A 632
THR A 638
VAL A 415
 None
 1.37A 1o76A-1ijqA:
0.0		 1o76A-1ijqA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4y LIVER
CARBOXYLESTERASE

(Oryctolagus
cuniculus) 		PF00135
(COesterase) 		5 THR A 123
LEU A 127
VAL A  26
THR A  80
VAL A  53
 None
 1.45A 1o76A-1k4yA:
0.0		 1o76A-1k4yA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		5 TYR A1181
LEU A1103
VAL A1063
THR A1161
VAL A1157
 None
 1.34A 1o76A-1k7yA:
0.0		 1o76A-1k7yA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		5 TYR A1181
LEU A1103
VAL A1063
THR A1161
VAL A1157
 None
 1.28A 1o76A-1mskA:
0.0		 1o76A-1mskA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n9b BETA-LACTAMASE SHV-2

(Klebsiella
pneumoniae) 		PF13354
(Beta-lactamase2) 		5 THR A  71
LEU A 152
VAL A  75
VAL A 262
VAL A 247
 None
 1.42A 1o76A-1n9bA:
0.0		 1o76A-1n9bA:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 THR A 312
LEU A 308
VAL A 264
ASP A 320
VAL A 247
 None
 1.38A 1o76A-1p1mA:
undetectable		 1o76A-1p1mA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2v ACTIN-RELATED
PROTEIN 3

(Bos taurus) 		PF00022
(Actin) 		5 THR A 326
VAL A 367
THR A 166
VAL A 177
VAL A 300
 None
 1.40A 1o76A-1u2vA:
undetectable		 1o76A-1u2vA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6c ALKALINE SERINE
PROTEASE

(Pseudoalteromonas
sp. AS-11) 		PF00082
(Peptidase_S8)
PF02225
(PA) 		5 THR A 352
LEU A 257
THR A 340
VAL A 231
VAL A 336
 None
 1.32A 1o76A-1v6cA:
undetectable		 1o76A-1v6cA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbm TYROSYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00579
(tRNA-synt_1b) 		5 PHE A 236
THR A 263
LEU A 303
VAL A 307
VAL A 244
 None
 1.36A 1o76A-1vbmA:
undetectable		 1o76A-1vbmA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 PHE A 415
LEU A 393
VAL A 389
VAL A 363
VAL A 366
 None
 1.33A 1o76A-1wytA:
undetectable		 1o76A-1wytA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yns E-1 ENZYME

(Homo sapiens) 		no annotation 5 THR A 107
LEU A 110
VAL A  97
ASP A  66
VAL A  73
 None
 1.28A 1o76A-1ynsA:
undetectable		 1o76A-1ynsA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 THR A 176
THR A 235
LEU A 216
VAL A 213
ASP A 270
 MG  A 602 ( 3.3A)
None
None
None
MG  A 602 ( 4.8A)
 1.16A 1o76A-2f43A:
undetectable		 1o76A-2f43A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fi1 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		5 PHE A  66
TYR A  70
THR A  52
LEU A  48
VAL A  44
 None
 1.50A 1o76A-2fi1A:
undetectable		 1o76A-2fi1A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2htm THIAZOLE
BIOSYNTHESIS PROTEIN
THIG

(Thermus
thermophilus) 		PF05690
(ThiG) 		5 THR A  41
THR A 148
LEU A 205
VAL A 182
VAL A   6
 None
 1.45A 1o76A-2htmA:
undetectable		 1o76A-2htmA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iue INTEGRIN BETA-2-LIKE
PROTEIN

(Mus musculus) 		PF00362
(Integrin_beta) 		5 PHE A 116
TYR A 179
THR A 112
LEU A 110
VAL A  89
 None
 1.45A 1o76A-2iueA:
undetectable		 1o76A-2iueA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j04 YDR362CP

(Saccharomyces
cerevisiae) 		no annotation 5 PHE B 458
VAL B 482
THR B 484
VAL B 462
ASP B 460
 None
 1.48A 1o76A-2j04B:
undetectable		 1o76A-2j04B:
21.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
LEU A 244
THR A 252
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-4.5A)
HEM  A 501 (-3.4A)
None
 1.31A 1o76A-2m56A:
69.4		 1o76A-2m56A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		5 PHE A  87
TYR A  96
THR A 101
LEU A 244
VAL A 295
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
HEM  A 501 (-4.5A)
HEM  A 501 (-4.6A)
 0.93A 1o76A-2m56A:
69.4		 1o76A-2m56A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		10 PHE A  87
TYR A  96
THR A 101
THR A 185
LEU A 244
VAL A 247
THR A 252
VAL A 295
ASP A 297
VAL A 396
 CAM  A 502 (-4.6A)
CAM  A 502 (-4.5A)
HEM  A 501 (-2.9A)
None
HEM  A 501 (-4.5A)
None
HEM  A 501 (-3.4A)
HEM  A 501 (-4.6A)
HEM  A 501 (-2.8A)
None
 0.49A 1o76A-2m56A:
69.4		 1o76A-2m56A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x63 ALPHA-2,3-/2,8-SIALY
LTRANSFERASE

(Campylobacter
jejuni) 		PF06002
(CST-I) 		5 PHE A  35
TYR A  34
THR A  61
THR A 166
ASP A 242
 None
 1.42A 1o76A-2x63A:
undetectable		 1o76A-2x63A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 THR A1245
LEU A1140
VAL A1146
VAL A1163
VAL A1250
 None
 1.32A 1o76A-2zxqA:
undetectable		 1o76A-2zxqA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy PROTEIN HEADING DATE
3A

(Oryza sativa) 		PF01161
(PBP) 		5 THR A 146
LEU A  69
VAL A  70
VAL A  16
VAL A  20
 None
 1.36A 1o76A-3axyA:
undetectable		 1o76A-3axyA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cc8 PUTATIVE
METHYLTRANSFERASE

(Bacillus cereus) 		PF13489
(Methyltransf_23) 		5 LEU A  25
THR A  54
VAL A  56
ASP A  37
VAL A  35
 None
 1.41A 1o76A-3cc8A:
undetectable		 1o76A-3cc8A:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dlt ESTERASE D

(Lactobacillus
rhamnosus) 		PF12146
(Hydrolase_4) 		5 THR A 222
LEU A 230
VAL A 234
VAL A  45
VAL A  18
 None
 1.20A 1o76A-3dltA:
undetectable		 1o76A-3dltA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		5 PHE A 105
TYR A 447
LEU A 425
THR A 509
VAL A 512
 None
 1.41A 1o76A-3j1cA:
undetectable		 1o76A-3j1cA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0c LOW-DENSITY
LIPOPROTEIN RECEPTOR

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		5 THR C 413
LEU C 380
VAL C 632
THR C 638
VAL C 415
 None
 1.37A 1o76A-3m0cC:
undetectable		 1o76A-3m0cC:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 THR A  64
LEU A  77
VAL A  72
THR A  47
VAL A  43
 None
 1.28A 1o76A-3oetA:
undetectable		 1o76A-3oetA:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pop GILR OXIDASE

(Streptomyces
griseoflavus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 THR A 489
LEU A  80
VAL A  58
VAL A 167
VAL A 161
 None
 1.48A 1o76A-3popA:
undetectable		 1o76A-3popA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 THR A 131
LEU A 139
VAL A  99
THR A 147
VAL A 128
 None
 1.38A 1o76A-3pxxA:
undetectable		 1o76A-3pxxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsq CAPSID POLYPROTEIN

(Mamastrovirus 1) 		PF12226
(Astro_capsid_p) 		5 PHE A 638
THR A 591
LEU A 626
VAL A 484
VAL A 438
 None
 1.41A 1o76A-3qsqA:
undetectable		 1o76A-3qsqA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 TYR A 289
THR A 293
LEU A  15
THR A 144
ASP A 300
 None
 1.23A 1o76A-3t6sA:
undetectable		 1o76A-3t6sA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ubm FORMYL-COA:OXALATE
COA-TRANSFERASE

(Acetobacter
aceti) 		PF02515
(CoA_transf_3) 		5 LEU A 195
VAL A 199
VAL A  39
ASP A  18
VAL A  16
 None
 1.34A 1o76A-3ubmA:
undetectable		 1o76A-3ubmA:
22.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 TYR A  98
THR A 103
LEU A 252
THR A 260
VAL A 404
 None
GOL  A1419 (-3.8A)
HEM  A1418 (-4.0A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.5A)
 1.21A 1o76A-4c9mA:
58.9		 1o76A-4c9mA:
44.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		8 TYR A  98
THR A 103
THR A 187
LEU A 252
THR A 260
VAL A 303
ASP A 305
VAL A 404
 None
GOL  A1419 (-3.8A)
None
HEM  A1418 (-4.0A)
HEM  A1418 (-3.6A)
GOL  A1419 (-3.9A)
HEM  A1418 (-2.7A)
GOL  A1419 (-3.5A)
 0.60A 1o76A-4c9mA:
58.9		 1o76A-4c9mA:
44.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czw PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Neurospora
crassa) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		5 THR A 593
LEU A 508
VAL A 511
THR A 515
VAL A 721
 None
 1.02A 1o76A-4czwA:
undetectable		 1o76A-4czwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 TYR A 130
THR A 146
THR A 140
VAL A  88
VAL A 134
 None
 1.39A 1o76A-4dn7A:
undetectable		 1o76A-4dn7A:
20.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		6 PHE A  87
THR A 101
LEU A 250
THR A 258
VAL A 301
VAL A 402
 None
HEM  A 501 ( 4.8A)
HEM  A 501 (-4.3A)
HEM  A 501 (-3.7A)
PEG  A 502 ( 4.5A)
None
 0.86A 1o76A-4dxyA:
52.3		 1o76A-4dxyA:
46.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0q RESTRICTION
ENDONUCLEASE

(Mycobacterium
sp. JLS) 		PF04471
(Mrr_cat) 		5 TYR A 293
THR A 437
LEU A 433
VAL A 418
VAL A 386
 None
 1.21A 1o76A-4f0qA:
undetectable		 1o76A-4f0qA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fc4 NITRITE TRANSPORTER
NIRC

(Salmonella
enterica) 		PF01226
(Form_Nir_trans) 		5 PHE A 190
THR A  81
LEU A  79
VAL A  38
THR A 203
 None
 1.44A 1o76A-4fc4A:
undetectable		 1o76A-4fc4A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fix UDP-GALACTOFURANOSYL
TRANSFERASE GLFT2

(Mycobacterium
tuberculosis) 		PF13641
(Glyco_tranf_2_3) 		5 THR A 454
THR A 568
VAL A 575
ASP A 492
VAL A 495
 None
 1.47A 1o76A-4fixA:
undetectable		 1o76A-4fixA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		5 THR A 583
THR A 310
LEU A 290
VAL A 286
VAL A 313
 None
 1.23A 1o76A-4hhrA:
undetectable		 1o76A-4hhrA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
ATP-BINDING PROTEIN
ECFA 1

(Lactobacillus
brevis) 		PF00005
(ABC_tran) 		5 THR B 198
LEU B  28
VAL B  30
VAL B  87
VAL B 166
 None
 1.06A 1o76A-4hzuB:
undetectable		 1o76A-4hzuB:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xxw PROTOCADHERIN-15

(Mus musculus) 		no annotation 5 PHE B 183
TYR B 207
LEU B 234
VAL B 135
VAL B 141
 None
 1.37A 1o76A-4xxwB:
undetectable		 1o76A-4xxwB:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymw ABC-TYPE POLAR AMINO
ACID TRANSPORT
SYSTEM, ATPASE
COMPONENT

(Caldanaerobacter
subterraneus) 		no annotation 5 THR J 188
LEU J  22
VAL J  24
VAL J  79
VAL J 157
 None
 1.16A 1o76A-4ymwJ:
undetectable		 1o76A-4ymwJ:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9n AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Brucella ovis) 		PF00497
(SBP_bac_3) 		5 PHE A 206
THR A  83
LEU A  22
THR A 136
ASP A 103
 None
GSH  A 401 (-4.1A)
GSH  A 401 ( 4.7A)
GSH  A 401 ( 4.8A)
None
 1.36A 1o76A-4z9nA:
undetectable		 1o76A-4z9nA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 THR A  35
LEU A 405
VAL A 398
VAL A 431
VAL A  21
 None
 1.33A 1o76A-5a0tA:
undetectable		 1o76A-5a0tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah4 DNA POLYMERASE III
SUBUNIT BETA

(Mycolicibacterium
smegmatis) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 THR A  88
LEU A  84
VAL A  43
VAL A  67
VAL A  65
 None
 1.30A 1o76A-5ah4A:
undetectable		 1o76A-5ah4A:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PHE A  98
TYR A  94
THR A 231
VAL A 177
VAL A 166
 None
 1.36A 1o76A-5dmhA:
undetectable		 1o76A-5dmhA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dst PROTEIN ARGININE
N-METHYLTRANSFERASE
8

(Homo sapiens) 		PF06325
(PrmA) 		5 THR A 270
LEU A 346
VAL A 304
VAL A 223
VAL A 224
 None
 1.44A 1o76A-5dstA:
undetectable		 1o76A-5dstA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exc GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		5 PHE I  79
TYR I 177
THR I 175
THR I  69
VAL I 191
 None
 1.44A 1o76A-5excI:
undetectable		 1o76A-5excI:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 PHE A 655
TYR A 656
VAL A 276
VAL A 175
VAL A 218
 None
 1.44A 1o76A-5f7sA:
undetectable		 1o76A-5f7sA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgd PLATELET
GLYCOPROTEIN 4

(Homo sapiens) 		PF01130
(CD36) 		5 PHE A 122
TYR A  93
THR A 130
LEU A 179
VAL A 128
 None
None
NAG  A 507 ( 4.7A)
None
None
 1.42A 1o76A-5lgdA:
undetectable		 1o76A-5lgdA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		5 THR A 174
LEU A 120
VAL A 123
VAL A 136
VAL A  75
 None
 1.31A 1o76A-5malA:
undetectable		 1o76A-5malA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nkn NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN

(Homo sapiens) 		no annotation 5 PHE A 134
THR A 136
LEU A  94
THR A  54
VAL A  33
 LOC  A 201 (-3.8A)
LOC  A 201 (-3.5A)
None
LOC  A 201 ( 4.6A)
None
 1.38A 1o76A-5nknA:
undetectable		 1o76A-5nknA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160
ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1;
Human
immunodeficiency
virus 1) 		no annotation
no annotation 		5 THR A 639
VAL G  38
VAL G  44
ASP A 632
VAL G  42
 None
 1.43A 1o76A-5wduA:
undetectable		 1o76A-5wduA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 5 PHE A 428
THR A 501
THR A 309
VAL A 384
VAL A 306
 None
 1.46A 1o76A-6d35A:
undetectable		 1o76A-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d47 BETA SLIDING CLAMP

(Mycobacterium
marinum) 		no annotation 5 THR A  90
LEU A  86
VAL A  45
VAL A  69
VAL A  67
 None
 1.30A 1o76A-6d47A:
undetectable		 1o76A-6d47A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 PHE A  34
TYR A  30
THR A 213
LEU A 274
VAL A 325
 None
 1.32A 1o76A-6eu6A:
undetectable		 1o76A-6eu6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fi2 VEXL

(Achromobacter
denitrificans) 		no annotation 5 THR A 188
LEU A 166
VAL A 150
VAL A 183
VAL A 159
 None
 1.41A 1o76A-6fi2A:
undetectable		 1o76A-6fi2A:
undetectable