SIMILAR PATTERNS OF AMINO ACIDS FOR 1NW5_A_SAMA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		3 ASP A  99
HIS A  91
ASP A  51
 GLC  A 550 (-2.5A)
GLC  A 550 (-3.8A)
GLC  A 550 (-3.1A)
 0.76A 1nw5A-1b1yA:
undetectable		 1nw5A-1b1yA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE
PENICILLIN G AMIDASE

(Providencia
rettgeri;
Providencia
rettgeri) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		3 ASP B 538
HIS A  16
ASP A  10
 None
 0.88A 1nw5A-1cp9B:
undetectable		 1nw5A-1cp9B:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		3 ASP A 232
HIS A 285
ASP A 280
 None
 0.87A 1nw5A-1fs2A:
undetectable		 1nw5A-1fs2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gcy GLUCAN
1,4-ALPHA-MALTOTETRA
HYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		3 ASP A  62
HIS A 117
ASP A 193
 None
 0.79A 1nw5A-1gcyA:
undetectable		 1nw5A-1gcyA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF13247
(Fer4_11) 		3 ASP B  60
HIS B 203
ASP B  64
 None
 0.68A 1nw5A-1h0hB:
undetectable		 1nw5A-1h0hB:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 ASP A 255
HIS A 196
ASP A  65
 None
ZN  A 400 (-3.3A)
None
 0.64A 1nw5A-1kwmA:
2.1		 1nw5A-1kwmA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6u NDT80 PROTEIN

(Saccharomyces
cerevisiae) 		PF05224
(NDT80_PhoG) 		3 ASP A 165
HIS A 276
ASP A 162
 None
 0.77A 1nw5A-1m6uA:
undetectable		 1nw5A-1m6uA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		3 ASP A 517
HIS A 558
ASP A 522
 None
 0.89A 1nw5A-1m9iA:
undetectable		 1nw5A-1m9iA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nsa PROCARBOXYPEPTIDASE
B

(Sus scrofa) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 ASP A 255
HIS A 196
ASP A  65
 BEN  A   1 (-3.1A)
ZN  A 501 (-3.2A)
None
 0.73A 1nw5A-1nsaA:
undetectable		 1nw5A-1nsaA:
20.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nw5 MODIFICATION
METHYLASE RSRI

(Rhodobacter
sphaeroides) 		PF01555
(N6_N4_Mtase) 		3 ASP A  65
HIS A 223
ASP A 271
 SAM  A 401 (-3.3A)
SAM  A 401 (-4.0A)
SAM  A 401 (-2.9A)
 0.01A 1nw5A-1nw5A:
46.9		 1nw5A-1nw5A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pqn SPLICEOSOMAL U5
SNRNP-SPECIFIC 15
KDA PROTEIN

(Homo sapiens) 		PF02966
(DIM1) 		3 ASP A  42
HIS A   7
ASP A  33
 None
 0.67A 1nw5A-1pqnA:
undetectable		 1nw5A-1pqnA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)

(Stenotrophomonas
maltophilia) 		PF00753
(Lactamase_B) 		3 ASP A 121
HIS A  84
ASP A  88
 None
ZN  A 271 (-3.2A)
ZN  A 270 (-2.4A)
 0.78A 1nw5A-1smlA:
undetectable		 1nw5A-1smlA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt4 PUTATIVE CYTOPLASMIC
PROTEIN

(Salmonella
enterica) 		PF04107
(GCS2) 		3 ASP A 298
HIS A 156
ASP A 310
 None
 0.57A 1nw5A-1tt4A:
undetectable		 1nw5A-1tt4A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ASP A 426
HIS A 385
ASP A 350
 None
 0.86A 1nw5A-1v7vA:
undetectable		 1nw5A-1v7vA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		3 ASP A  97
HIS A  89
ASP A  49
 GLC  A 900 (-2.8A)
GLC  A 900 (-4.0A)
GLC  A 900 (-2.9A)
 0.76A 1nw5A-1venA:
undetectable		 1nw5A-1venA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk9 ADENYLATE CYCLASE

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc) 		3 ASP A 314
HIS A 290
ASP A 321
 None
 0.87A 1nw5A-1yk9A:
undetectable		 1nw5A-1yk9A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		3 ASP A 316
HIS A 153
ASP A 273
 ZN  A 901 ( 1.9A)
SEP  A  92 ( 4.5A)
None
 0.78A 1nw5A-1zefA:
undetectable		 1nw5A-1zefA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zli CARBOXYPEPTIDASE B

(Homo sapiens) 		PF00246
(Peptidase_M14) 		3 ASP A 255
HIS A 196
ASP A  65
 None
ZN  A 501 (-3.3A)
None
 0.72A 1nw5A-1zliA:
undetectable		 1nw5A-1zliA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amg 1,4-ALPHA-D-GLUCAN
MALTOTETRAHYDROLASE

(Pseudomonas
stutzeri) 		PF00128
(Alpha-amylase)
PF09081
(DUF1921) 		3 ASP A  62
HIS A 117
ASP A 193
 None
 0.82A 1nw5A-2amgA:
undetectable		 1nw5A-2amgA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		3 ASP A 291
HIS A 259
ASP A 294
 GDP  A 400 (-2.8A)
None
None
 0.84A 1nw5A-2e87A:
undetectable		 1nw5A-2e87A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 ASP A 275
HIS A 287
ASP A 302
 None
 0.62A 1nw5A-2ifyA:
2.1		 1nw5A-2ifyA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o57 PUTATIVE SARCOSINE
DIMETHYLGLYCINE
METHYLTRANSFERASE

(Galdieria
sulphuraria) 		PF08241
(Methyltransf_11) 		3 ASP A  88
HIS A  46
ASP A  67
 None
 0.86A 1nw5A-2o57A:
4.4		 1nw5A-2o57A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q14 PHOSPHOHYDROLASE

(Bacteroides
thetaiotaomicron) 		PF01966
(HD) 		3 ASP A 165
HIS A  95
ASP A 160
 None
 0.90A 1nw5A-2q14A:
undetectable		 1nw5A-2q14A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vhf UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE CYLD

(Homo sapiens) 		PF00443
(UCH) 		3 ASP A 604
HIS A 871
ASP A 889
 None
 0.87A 1nw5A-2vhfA:
undetectable		 1nw5A-2vhfA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuw SERINE/THREONINE-PRO
TEIN KINASE HASPIN

(Homo sapiens) 		PF12330
(Haspin_kinase) 		3 ASP A 611
HIS A 651
ASP A 687
 5ID  A1800 (-3.6A)
None
IOD  A1799 (-4.0A)
 0.78A 1nw5A-2vuwA:
undetectable		 1nw5A-2vuwA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wrt GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME 51

(Fasciola
hepatica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ASP A  37
HIS A  31
ASP A  44
 None
 0.60A 1nw5A-2wrtA:
undetectable		 1nw5A-2wrtA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5q SSO1986

(Sulfolobus
solfataricus) 		no annotation 3 ASP A  49
HIS A  53
ASP A 180
 None
 0.78A 1nw5A-2x5qA:
undetectable		 1nw5A-2x5qA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z66 VARIABLE LYMPHOCYTE
RECEPTOR B,
TOLL-LIKE RECEPTOR 4

(Eptatretus
burgeri;
Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 ASP A 395
HIS A  68
ASP A  72
 None
 0.58A 1nw5A-2z66A:
undetectable		 1nw5A-2z66A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ASP A 422
HIS A 403
ASP A 368
 None
 0.79A 1nw5A-3actA:
undetectable		 1nw5A-3actA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 ASP A 955
HIS A 587
ASP A 909
 None
 0.85A 1nw5A-3aibA:
undetectable		 1nw5A-3aibA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori) 		PF07804
(HipA_C) 		3 ASP A  99
HIS A 157
ASP A 179
 None
None
ADP  A 500 ( 3.1A)
 0.73A 1nw5A-3akkA:
undetectable		 1nw5A-3akkA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bio OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY

(Porphyromonas
gingivalis) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		3 ASP A 205
HIS A 156
ASP A 211
 None
 0.58A 1nw5A-3bioA:
2.9		 1nw5A-3bioA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxx TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE

(Escherichia
coli) 		PF02390
(Methyltransf_4) 		3 ASP A 144
HIS A 147
ASP A 180
 None
 0.85A 1nw5A-3dxxA:
2.8		 1nw5A-3dxxA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e15 GLUCOSE-6-PHOSPHATE
1-DEHYDROGENASE

(Plasmodium
vivax) 		PF01182
(Glucosamine_iso) 		3 ASP A 221
HIS A 163
ASP A  90
 None
 0.87A 1nw5A-3e15A:
undetectable		 1nw5A-3e15A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez6 PLASMID PARTITION
PROTEIN A

(Escherichia
coli) 		PF13614
(AAA_31) 		3 ASP A 390
HIS A 136
ASP A 383
 None
 0.73A 1nw5A-3ez6A:
undetectable		 1nw5A-3ez6A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 242
HIS A 425
ASP A 245
 MG  A   1 ( 3.7A)
None
None
 0.86A 1nw5A-3fhtA:
3.1		 1nw5A-3fhtA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g1p PROTEIN PHNP

(Escherichia
coli) 		PF12706
(Lactamase_B_2) 		3 ASP A  80
HIS A 143
ASP A 187
 MLT  A 500 ( 2.8A)
MN  A 400 ( 3.4A)
None
 0.89A 1nw5A-3g1pA:
undetectable		 1nw5A-3g1pA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbz PUTATIVE GLYCOSIDE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF13201
(PCMD) 		3 ASP A  61
HIS A  88
ASP A 112
 None
 0.87A 1nw5A-3hbzA:
undetectable		 1nw5A-3hbzA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2e GLYCOCYAMINE KINASE
ALPHA CHAIN

(Namalycastis
sp. ST01) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 ASP A 194
HIS A 230
ASP A 201
 None
 0.73A 1nw5A-3l2eA:
undetectable		 1nw5A-3l2eA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lms CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		3 ASP A 255
HIS A 196
ASP A  65
 None
ZN  A 309 (-3.2A)
None
 0.66A 1nw5A-3lmsA:
undetectable		 1nw5A-3lmsA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		3 ASP A  85
HIS A 448
ASP A 446
 None
 0.90A 1nw5A-3m07A:
1.6		 1nw5A-3m07A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1g PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Corynebacterium
glutamicum) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		3 ASP A  29
HIS A  51
ASP A 157
 None
GOL  A 362 (-3.9A)
None
 0.90A 1nw5A-3m1gA:
undetectable		 1nw5A-3m1gA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqc UFM1-SPECIFIC
PROTEASE 2

(Mus musculus) 		PF07910
(Peptidase_C78) 		3 ASP A 250
HIS A 280
ASP A 285
 None
 0.79A 1nw5A-3oqcA:
undetectable		 1nw5A-3oqcA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		3 ASP A 118
HIS A 160
ASP A 176
 None
 0.76A 1nw5A-3pg1A:
undetectable		 1nw5A-3pg1A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qde CELLOBIOSE
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ASP A 415
HIS A 396
ASP A 361
 None
 0.82A 1nw5A-3qdeA:
undetectable		 1nw5A-3qdeA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qj3 CATHEPSIN L-LIKE
PROTEIN

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		3 ASP A 245
HIS A  76
ASP A 242
 None
 0.89A 1nw5A-3qj3A:
undetectable		 1nw5A-3qj3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 267
HIS A 462
ASP A 270
 MG  A 900 ( 3.7A)
None
None
 0.87A 1nw5A-3sqwA:
2.6		 1nw5A-3sqwA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3o METAL DEPENDENT
HYDROLASE

(Thermus
thermophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		3 ASP A  79
HIS A 150
ASP A 204
 ZN  A 600 (-2.5A)
None
None
 0.86A 1nw5A-3t3oA:
undetectable		 1nw5A-3t3oA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8l ADENINE DEAMINASE 2

(Agrobacterium
fabrum) 		PF01979
(Amidohydro_1)
PF13382
(Adenine_deam_C) 		3 ASP A 289
HIS A 218
ASP A 238
 UNX  A 608 ( 2.4A)
UNX  A 606 ( 3.2A)
None
 0.86A 1nw5A-3t8lA:
undetectable		 1nw5A-3t8lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsv XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF13229
(Beta_helix) 		3 ASP A 562
HIS A 339
ASP A 559
 None
XYP  A 702 (-4.6A)
XYP  A 702 ( 4.0A)
 0.90A 1nw5A-3vsvA:
undetectable		 1nw5A-3vsvA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbb DIAMINOPIMELATE
DEHYDROGENASE

(Symbiobacterium
thermophilum) 		PF01408
(GFO_IDH_MocA)
PF16654
(DAPDH_C) 		3 ASP A 203
HIS A 154
ASP A 209
 None
 0.72A 1nw5A-3wbbA:
2.9		 1nw5A-3wbbA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkq NITRITE REDUCTASE

(Geobacillus
thermodenitrificans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A  90
HIS A 143
ASP A 112
 None
CU  A 401 (-3.1A)
None
 0.78A 1nw5A-3wkqA:
undetectable		 1nw5A-3wkqA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq4 RIBONUCLEASE J 1

(Bacillus
subtilis) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 ASP A  78
HIS A 142
ASP A 195
 ZN  A1556 (-2.5A)
ZN  A1557 (-3.3A)
None
 0.85A 1nw5A-3zq4A:
2.8		 1nw5A-3zq4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aqs LAMININ SUBUNIT
BETA-1

(Mus musculus) 		PF00053
(Laminin_EGF)
PF00055
(Laminin_N) 		3 ASP A 363
HIS A 317
ASP A 314
 None
 0.88A 1nw5A-4aqsA:
undetectable		 1nw5A-4aqsA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ayg GLUCANSUCRASE

(Lactobacillus
reuteri) 		PF01473
(CW_binding_1)
PF02324
(Glyco_hydro_70) 		3 ASP A1504
HIS A1135
ASP A1458
 None
None
GOL  A2773 (-2.8A)
 0.86A 1nw5A-4aygA:
undetectable		 1nw5A-4aygA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d25 BMVLG PROTEIN

(Bombyx mori) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 338
HIS A 517
ASP A 341
 MG  A1565 ( 3.7A)
None
None
 0.84A 1nw5A-4d25A:
2.4		 1nw5A-4d25A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		3 ASP A 128
HIS A  36
ASP A  32
 None
 0.86A 1nw5A-4eqvA:
undetectable		 1nw5A-4eqvA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3l CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT
BMAL1B

(Mus musculus;
Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		3 ASP B 156
HIS B 321
ASP A 119
 None
 0.86A 1nw5A-4f3lB:
undetectable		 1nw5A-4f3lB:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		3 ASP A 309
HIS A 386
ASP A 143
 None
PLP  A 501 (-3.8A)
None
 0.74A 1nw5A-4f4fA:
undetectable		 1nw5A-4f4fA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		3 ASP A 413
HIS A 440
ASP A 434
 None
 0.87A 1nw5A-4fusA:
undetectable		 1nw5A-4fusA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4he5 PEPTIDASE FAMILY U32

(Geobacillus
thermoleovorans) 		PF16325
(Peptidase_U32_C) 		3 ASP A 395
HIS A 362
ASP A 367
 None
SO4  A 501 (-4.0A)
None
 0.89A 1nw5A-4he5A:
undetectable		 1nw5A-4he5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjw URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Metarhizium
anisopliae) 		PF04909
(Amidohydro_2) 		3 ASP A  85
HIS A 127
ASP A  78
 None
 0.90A 1nw5A-4hjwA:
undetectable		 1nw5A-4hjwA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hou INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		PF13181
(TPR_8)
PF13424
(TPR_12) 		3 ASP A 189
HIS A 198
ASP A 229
 None
 0.88A 1nw5A-4houA:
undetectable		 1nw5A-4houA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5o PUTATIVE GLUTATHIONE
TRANSFERASE

(Clonorchis
sinensis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ASP A  37
HIS A  31
ASP A  44
 None
 0.53A 1nw5A-4l5oA:
undetectable		 1nw5A-4l5oA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mfz DBV8 PROTEIN

(Nonomuraea
gerenzanensis) 		no annotation 3 ASP A 271
HIS A 302
ASP A 240
 None
 0.74A 1nw5A-4mfzA:
undetectable		 1nw5A-4mfzA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mk0 BETA-ADRENERGIC
RECEPTOR KINASE 1

(Homo sapiens) 		PF00069
(Pkinase)
PF00169
(PH)
PF00615
(RGS) 		3 ASP A 169
HIS A  75
ASP A  70
 None
 0.82A 1nw5A-4mk0A:
undetectable		 1nw5A-4mk0A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mlg BETA-XYLOSIDASE

(uncultured
organism) 		PF04616
(Glyco_hydro_43) 		3 ASP A  85
HIS A 289
ASP A  32
 CA  A 401 (-2.6A)
None
None
 0.89A 1nw5A-4mlgA:
undetectable		 1nw5A-4mlgA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1x GAMMA-HEMOLYSIN
COMPONENT C

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 ASP B 222
HIS B 216
ASP B  86
 None
 0.80A 1nw5A-4p1xB:
undetectable		 1nw5A-4p1xB:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pu5 TOXIN-ANTITOXIN
SYSTEM TOXIN HIPA
FAMILY

(Shewanella
oneidensis) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		3 ASP A 240
HIS A 308
ASP A 328
 None
ANP  A 503 (-3.7A)
MG  A 501 (-1.9A)
 0.73A 1nw5A-4pu5A:
undetectable		 1nw5A-4pu5A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pvg TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 11

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ASP A 437
HIS A 520
ASP A 431
 None
 0.75A 1nw5A-4pvgA:
2.2		 1nw5A-4pvgA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q38 PUTATIVE
UNCHARACTERIZED
PROTEIN TCP24

(Actinoplanes
teichomyceticus) 		no annotation 3 ASP A 275
HIS A 306
ASP A 240
 None
 0.63A 1nw5A-4q38A:
undetectable		 1nw5A-4q38A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnl POSSIBLE GALACTOSE
MUTAROTASE

(Streptomyces
platensis) 		PF01263
(Aldose_epim) 		3 ASP A 311
HIS A 107
ASP A 208
 None
 0.89A 1nw5A-4rnlA:
undetectable		 1nw5A-4rnlA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides) 		PF02324
(Glyco_hydro_70) 		3 ASP A2689
HIS A2321
ASP A2643
 None
None
GOL  A3008 (-2.6A)
 0.85A 1nw5A-4tvcA:
undetectable		 1nw5A-4tvcA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7s PRE-MRNA-SPLICING
ATP-DEPENDENT RNA
HELICASE PRP28

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 150
HIS A 137
ASP A 157
 None
 0.86A 1nw5A-4w7sA:
3.1		 1nw5A-4w7sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwt DR2417

(Deinococcus
radiodurans) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 ASP A  88
HIS A 153
ASP A 209
 ZN  A 602 (-2.7A)
ZN  A 601 (-3.4A)
None
 0.76A 1nw5A-4xwtA:
2.6		 1nw5A-4xwtA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA

(Escherichia
coli) 		PF07804
(HipA_C)
PF13657
(Couple_hipA) 		3 ASP D 254
HIS D 311
ASP D 332
 None
 0.80A 1nw5A-4yg7D:
undetectable		 1nw5A-4yg7D:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ykn PHOSPHATIDYLINOSITOL
3-KINASE REGULATORY
SUBUNIT
ALPHA,PHOSPHATIDYLIN
OSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT ALPHA
ISOFORM FUSION
PROTEIN

(Homo sapiens) 		PF00017
(SH2)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
PF16454
(PI3K_P85_iSH2) 		3 ASP A1915
HIS A1936
ASP A1933
 None
None
4EL  A2101 (-4.6A)
 0.89A 1nw5A-4yknA:
undetectable		 1nw5A-4yknA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zbt ACETOACETATE
DECARBOXYLASE

(Streptomyces
bingchenggensis) 		PF06314
(ADC) 		3 ASP A  64
HIS A 247
ASP A 249
 None
 0.74A 1nw5A-4zbtA:
undetectable		 1nw5A-4zbtA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		3 ASP A  88
HIS A 151
ASP A 205
 ZN  A1457 (-2.7A)
ZN  A1458 (-3.6A)
None
 0.80A 1nw5A-5a0tA:
3.0		 1nw5A-5a0tA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0z CHOLINE
TRIMETHYLAMINE LYASE

(Klebsiella
pneumoniae) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ASP A 695
HIS A 642
ASP A 702
 None
 0.87A 1nw5A-5a0zA:
undetectable		 1nw5A-5a0zA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aho 5' EXONUCLEASE
APOLLO

(Homo sapiens) 		PF07522
(DRMBL) 		3 ASP A  35
HIS A  99
ASP A 145
 TLA  A1319 ( 2.7A)
ZN  A1321 ( 3.4A)
None
 0.85A 1nw5A-5ahoA:
undetectable		 1nw5A-5ahoA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		3 ASP A 207
HIS A 215
ASP A 218
 FE  A1001 ( 2.7A)
DG3  A2001 (-3.4A)
None
 0.80A 1nw5A-5ao0A:
undetectable		 1nw5A-5ao0A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650) 		PF13649
(Methyltransf_25) 		3 ASP A 145
HIS A  59
ASP A  51
 None
SAH  A 301 (-4.2A)
SAH  A 301 ( 4.7A)
 0.86A 1nw5A-5bszA:
3.3		 1nw5A-5bszA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		3 ASP A  22
HIS A  51
ASP A 165
 None
 0.77A 1nw5A-5eksA:
3.3		 1nw5A-5eksA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elx ATP-DEPENDENT RNA
HELICASE DBP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 ASP A 239
HIS A 422
ASP A 242
 MG  A 502 ( 3.8A)
None
None
 0.83A 1nw5A-5elxA:
4.0		 1nw5A-5elxA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ASP A 158
HIS A 397
ASP A 223
 None
None
MN  A 805 (-2.6A)
 0.76A 1nw5A-5f56A:
3.5		 1nw5A-5f56A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6j ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C

(Human
immunodeficiency
virus 1) 		no annotation 3 ASP G  78
HIS G 216
ASP G  57
 None
 0.70A 1nw5A-5f6jG:
undetectable		 1nw5A-5f6jG:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fgn LIPOOLIGOSACCHARIDE
PHOSPHOETHANOLAMINE
TRANSFERASE A

(Neisseria
meningitidis) 		PF00884
(Sulfatase)
PF08019
(DUF1705) 		3 ASP A  47
HIS A  39
ASP A 176
 None
 0.89A 1nw5A-5fgnA:
undetectable		 1nw5A-5fgnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fll 6-CARBOXYHEXANOATE-C
OA LIGASE

(Bacillus
subtilis) 		PF03744
(BioW) 		3 ASP A 198
HIS A  53
ASP A 195
 None
PPV  A 701 (-4.0A)
MG  A 704 (-2.7A)
 0.82A 1nw5A-5fllA:
undetectable		 1nw5A-5fllA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP2

(Deformed wing
virus) 		PF00073
(Rhv) 		3 ASP B  50
HIS B 112
ASP B  53
 None
 0.75A 1nw5A-5g52B:
undetectable		 1nw5A-5g52B:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdj NFRA1

(Bacillus
megaterium) 		PF00881
(Nitroreductase) 		3 ASP A 113
HIS A  86
ASP A  82
 None
 0.89A 1nw5A-5hdjA:
undetectable		 1nw5A-5hdjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 ASP A 348
HIS A 288
ASP A 155
 FLC  A 509 ( 4.8A)
ZN  A 508 (-3.1A)
None
 0.67A 1nw5A-5hvfA:
undetectable		 1nw5A-5hvfA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1q CARBOXYPEPTIDASE B

(Sus scrofa) 		PF00246
(Peptidase_M14) 		3 ASP A 255
HIS A 196
ASP A  65
 CXA  A 402 (-3.5A)
ZN  A 401 ( 3.2A)
None
 0.71A 1nw5A-5j1qA:
undetectable		 1nw5A-5j1qA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jju UNCHARACTERIZED
PROTEIN RV2837C

(Mycobacterium
tuberculosis) 		PF01368
(DHH)
PF02272
(DHHA1) 		3 ASP A 130
HIS A 312
ASP A 181
 None
A  C1004 ( 3.7A)
MN  A1001 (-2.5A)
 0.82A 1nw5A-5jjuA:
undetectable		 1nw5A-5jjuA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o25 TMPDE

(Thermotoga
maritima) 		no annotation 3 ASP A 103
HIS A 286
ASP A 154
 None
PG4  A 403 ( 4.7A)
MN  A 402 (-2.8A)
 0.82A 1nw5A-5o25A:
undetectable		 1nw5A-5o25A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 3 ASP W 761
HIS W 756
ASP W 764
 None
 0.85A 1nw5A-5o9gW:
undetectable		 1nw5A-5o9gW:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 3 ASP A 198
HIS A 206
ASP A 288
 None
None
GOL  A 601 (-2.9A)
 0.87A 1nw5A-5vqdA:
undetectable		 1nw5A-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x4j UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		no annotation 3 ASP A 105
HIS A 440
ASP A 165
 None
ZN  A 502 ( 4.8A)
ZN  A 501 (-2.3A)
 0.89A 1nw5A-5x4jA:
undetectable		 1nw5A-5x4jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 10

(Homo sapiens) 		no annotation 3 ASP B  63
HIS B  69
ASP B  66
 None
 0.83A 1nw5A-6c9mB:
2.5		 1nw5A-6c9mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-) 		no annotation 3 ASP A 658
HIS A 552
ASP A 661
 None
 0.80A 1nw5A-6fg9A:
undetectable		 1nw5A-6fg9A:
undetectable