SIMILAR PATTERNS OF AMINO ACIDS FOR 1NT6_B_DVAB8

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogp SULFITE OXIDASE

(Arabidopsis
thaliana) 		PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer) 		4 GLY A 114
VAL A 112
TRP A 117
TRP A 371
 None
 1.42A 1nt6B-1ogpA:
undetectable		 1nt6B-1ogpA:
4.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I

(Triticum
aestivum) 		PF00704
(Glyco_hydro_18) 		4 GLY A 220
VAL A 186
TRP A 208
TRP A 201
 None
None
None
EDO  B1001 (-4.3A)
 1.19A 1nt6B-1ta3A:
undetectable		 1nt6B-1ta3A:
5.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		4 GLY A 192
VAL A 219
TRP A 194
TRP A 220
 SUC  A1003 (-3.8A)
None
None
None
 1.17A 1nt6B-1x3wA:
undetectable		 1nt6B-1x3wA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		4 GLY A 115
VAL A 127
TRP A 134
TRP A 130
 GOL  A 325 (-4.2A)
None
None
None
 1.22A 1nt6B-2aamA:
undetectable		 1nt6B-2aamA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eaf ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN

(Aeropyrum
pernix) 		PF13458
(Peripla_BP_6) 		4 GLY A 294
VAL A 273
TRP A 274
TRP A 245
 None
None
GOL  A 500 (-3.7A)
None
 0.98A 1nt6B-3eafA:
undetectable		 1nt6B-3eafA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwm UNCHARACTERIZED
PROTEIN YEDD

(Klebsiella
pneumoniae) 		PF13987
(YedD) 		4 GLY A  63
VAL A  59
TRP A  39
TRP A 128
 None
 1.48A 1nt6B-4hwmA:
undetectable		 1nt6B-4hwmA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		4 GLY B 345
VAL B 343
TRP B 371
TRP B 380
 None
 1.46A 1nt6B-5sy5B:
undetectable		 1nt6B-5sy5B:
3.62