SIMILAR PATTERNS OF AMINO ACIDS FOR 1NT5_A_DVAA6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ALA A 318
VAL A 320
TRP A 225
 None
 0.89A 1nt5A-1ex0A:
undetectable		 1nt5A-1ex0A:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ALA A 276
VAL A 278
TRP A 175
 None
 0.84A 1nt5A-1g0dA:
undetectable		 1nt5A-1g0dA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 ALA A 349
VAL A 352
TRP A 489
 None
 0.89A 1nt5A-1j3bA:
undetectable		 1nt5A-1j3bA:
4.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwg BETA-GALACTOSIDASE

(Thermus
thermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		3 ALA A 328
VAL A 332
TRP A 335
 None
 0.89A 1nt5A-1kwgA:
undetectable		 1nt5A-1kwgA:
2.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ALA A 299
VAL A 304
TRP A   3
 None
 0.71A 1nt5A-1ml4A:
undetectable		 1nt5A-1ml4A:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ALA A 302
VAL A 304
TRP A   3
 None
 0.81A 1nt5A-1ml4A:
undetectable		 1nt5A-1ml4A:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7r HYALURONIDASE

(Streptococcus
pneumoniae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		3 ALA A 830
VAL A 834
TRP A 835
 None
 0.78A 1nt5A-1n7rA:
undetectable		 1nt5A-1n7rA:
3.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obh LEUCYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2)
PF14795
(Leucyl-specific) 		3 ALA A 325
VAL A 305
TRP A 323
 None
 0.88A 1nt5A-1obhA:
undetectable		 1nt5A-1obhA:
2.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oij PUTATIVE
ALKYLSULFATASE ATSK

(Pseudomonas
putida) 		PF02668
(TauD) 		3 ALA C 266
VAL C 136
TRP C 137
 AKG  C1301 ( 3.7A)
None
None
 0.90A 1nt5A-1oijC:
undetectable		 1nt5A-1oijC:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2k MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		no annotation 3 ALA B  58
VAL B  60
TRP B  63
 None
 0.76A 1nt5A-1r2kB:
undetectable		 1nt5A-1r2kB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfo WHISKER ANTIGEN
CONTROL PROTEIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 ALA A  12
VAL A  21
TRP A  20
 None
 0.85A 1nt5A-1rfoA:
undetectable		 1nt5A-1rfoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 ALA A 129
VAL A 123
TRP A  51
 None
 0.65A 1nt5A-1sfrA:
undetectable		 1nt5A-1sfrA:
6.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 ALA B 183
VAL B 188
TRP B 191
 None
 0.89A 1nt5A-1ta3B:
undetectable		 1nt5A-1ta3B:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		3 ALA A 265
VAL A 270
TRP A 212
 None
None
NH3  A 402 ( 3.7A)
 0.82A 1nt5A-1u7gA:
undetectable		 1nt5A-1u7gA:
4.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 ALA A  99
VAL A  93
TRP A  34
 None
 0.88A 1nt5A-1womA:
undetectable		 1nt5A-1womA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x9n DNA LIGASE I

(Homo sapiens) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 ALA A 321
VAL A 319
TRP A 281
 None
 0.80A 1nt5A-1x9nA:
undetectable		 1nt5A-1x9nA:
2.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xpg 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Thermotoga
maritima) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 ALA A 202
VAL A 236
TRP A 212
 None
 0.85A 1nt5A-1xpgA:
undetectable		 1nt5A-1xpgA:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajh LEUCYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF13603
(tRNA-synt_1_2) 		3 ALA A 323
VAL A 303
TRP A 321
 None
 0.83A 1nt5A-2ajhA:
undetectable		 1nt5A-2ajhA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  99
VAL A  87
TRP A  88
 None
 0.88A 1nt5A-2d4wA:
undetectable		 1nt5A-2d4wA:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		3 ALA A 107
VAL A 101
TRP A  43
 None
 0.89A 1nt5A-2e3jA:
undetectable		 1nt5A-2e3jA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 ALA A 192
VAL A 190
TRP A 187
 None
 0.82A 1nt5A-2genA:
undetectable		 1nt5A-2genA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty EMB|CAB41934.1

(Arabidopsis
thaliana) 		PF03759
(PRONE) 		3 ALA A 261
VAL A 263
TRP A 266
 None
 0.80A 1nt5A-2ntyA:
undetectable		 1nt5A-2ntyA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8p 14-3-3 DOMAIN
CONTAINING PROTEIN

(Cryptosporidium
parvum) 		PF00244
(14-3-3) 		3 ALA A  18
VAL A  20
TRP A  23
 None
 0.85A 1nt5A-2o8pA:
undetectable		 1nt5A-2o8pA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6t TRANSCRIPTIONAL
REGULATOR, LRP/ASNC
FAMILY

(Neisseria
meningitidis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		3 ALA A  88
VAL A  90
TRP A  93
 None
 0.87A 1nt5A-2p6tA:
undetectable		 1nt5A-2p6tA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pag HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF14567
(SUKH_5) 		3 ALA A  11
VAL A  53
TRP A 132
 None
 0.90A 1nt5A-2pagA:
undetectable		 1nt5A-2pagA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		3 ALA A 123
VAL A 117
TRP A  60
 None
 0.89A 1nt5A-2psfA:
undetectable		 1nt5A-2psfA:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ALA A 281
VAL A 283
TRP A 180
 None
 0.83A 1nt5A-2q3zA:
undetectable		 1nt5A-2q3zA:
3.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ALA A  83
VAL A  85
TRP A 105
 None
 0.45A 1nt5A-2vakA:
undetectable		 1nt5A-2vakA:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 ALA A 117
VAL A 115
TRP A 112
 None
 0.87A 1nt5A-2w8qA:
undetectable		 1nt5A-2w8qA:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr5 PRO-ENZYME OF
L-PHENYLALANINE
OXIDASE

(Pseudomonas sp.
P-501) 		no annotation 3 ALA A  18
VAL A  21
TRP A 152
 None
 0.90A 1nt5A-2yr5A:
undetectable		 1nt5A-2yr5A:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3att PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01636
(APH) 		3 ALA A 338
VAL A 340
TRP A 209
 None
 0.81A 1nt5A-3attA:
undetectable		 1nt5A-3attA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayx MEMBRANE-BOUND
HYDROGENASE LARGE
SUBUNIT

(Hydrogenovibrio
marinus) 		PF00374
(NiFeSe_Hases) 		3 ALA A  94
VAL A 516
TRP A 365
 None
 0.88A 1nt5A-3ayxA:
undetectable		 1nt5A-3ayxA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv6 METAL-DEPENDENT
HYDROLASE

(Vibrio cholerae) 		PF13483
(Lactamase_B_3) 		3 ALA A 146
VAL A 148
TRP A 151
 None
 0.87A 1nt5A-3bv6A:
undetectable		 1nt5A-3bv6A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ALA A 111
VAL A 116
TRP A 119
 None
 0.86A 1nt5A-3cinA:
undetectable		 1nt5A-3cinA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ALA A 651
VAL A 658
TRP A 659
 None
 0.91A 1nt5A-3cmgA:
undetectable		 1nt5A-3cmgA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis) 		PF01274
(Malate_synthase) 		3 ALA A 452
VAL A 454
TRP A 457
 None
 0.77A 1nt5A-3cuxA:
undetectable		 1nt5A-3cuxA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxh CYTOCHROME B-C1
COMPLEX SUBUNIT 9

(Saccharomyces
cerevisiae) 		PF05365
(UCR_UQCRX_QCR9) 		3 ALA I  57
VAL I  52
TRP I  49
 None
 0.89A 1nt5A-3cxhI:
undetectable		 1nt5A-3cxhI:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxt NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		no annotation 3 ALA A  80
VAL A  82
TRP A  85
 None
 0.76A 1nt5A-3fxtA:
undetectable		 1nt5A-3fxtA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster) 		PF11935
(DUF3453) 		3 ALA A  28
VAL A  30
TRP A  33
 None
 0.87A 1nt5A-3gs3A:
undetectable		 1nt5A-3gs3A:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		3 ALA A 695
VAL A 698
TRP A 596
 None
 0.78A 1nt5A-3kflA:
undetectable		 1nt5A-3kflA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvg CLATHRIN HEAVY CHAIN
1

(Bos taurus) 		PF00637
(Clathrin) 		3 ALA A1112
VAL A1107
TRP A1108
 None
 0.89A 1nt5A-3lvgA:
undetectable		 1nt5A-3lvgA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ns1 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		3 ALA B 282
VAL B 258
TRP B 236
 None
FAD  B 606 (-3.6A)
None
 0.90A 1nt5A-3ns1B:
undetectable		 1nt5A-3ns1B:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		3 ALA A 319
VAL A 321
TRP A  26
 None
 0.79A 1nt5A-3p3lA:
undetectable		 1nt5A-3p3lA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 353
VAL A 355
TRP A 358
 None
 0.74A 1nt5A-3qldA:
undetectable		 1nt5A-3qldA:
3.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qom 6-PHOSPHO-BETA-GLUCO
SIDASE

(Lactobacillus
plantarum) 		PF00232
(Glyco_hydro_1) 		3 ALA A 475
VAL A 469
TRP A  14
 None
 0.88A 1nt5A-3qomA:
undetectable		 1nt5A-3qomA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r31 BETAINE ALDEHYDE
DEHYDROGENASE

(Agrobacterium
fabrum) 		PF00171
(Aldedh) 		3 ALA A 171
VAL A 176
TRP A  68
 None
 0.86A 1nt5A-3r31A:
undetectable		 1nt5A-3r31A:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgw MEMBRANE-BOUND
HYDROGENASE (NIFE)
LARGE SUBUNIT HOXG

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases) 		3 ALA L  93
VAL L 523
TRP L 366
 None
 0.89A 1nt5A-3rgwL:
undetectable		 1nt5A-3rgwL:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		3 ALA A 178
VAL A 180
TRP A  24
 None
 0.86A 1nt5A-3sttA:
undetectable		 1nt5A-3sttA:
5.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		3 ALA A  91
VAL A  85
TRP A  29
 None
 0.88A 1nt5A-3v48A:
undetectable		 1nt5A-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vea MACRODOMAIN TER
PROTEIN

(Yersinia pestis) 		no annotation 3 ALA B  49
VAL B  54
TRP B  70
 None
 0.85A 1nt5A-3veaB:
undetectable		 1nt5A-3veaB:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp9 ICE-BINDING PROTEIN

(Colwellia sp.
SLW05) 		PF11999
(DUF3494) 		3 ALA A   1
VAL A 135
TRP A 136
 None
 0.82A 1nt5A-3wp9A:
undetectable		 1nt5A-3wp9A:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs3 THAUMATIN-LIKE
PROTEIN

(Malus domestica) 		PF00314
(Thaumatin) 		3 ALA A  34
VAL A  13
TRP A  14
 None
 0.78A 1nt5A-3zs3A:
undetectable		 1nt5A-3zs3A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		3 ALA A 323
VAL A 303
TRP A 321
 None
 0.87A 1nt5A-4arcA:
undetectable		 1nt5A-4arcA:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		3 ALA A  94
VAL A 505
TRP A 368
 None
 0.86A 1nt5A-4c3oA:
undetectable		 1nt5A-4c3oA:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0q HYALURONATE LYASE

(Streptococcus
pneumoniae) 		PF02018
(CBM_4_9) 		3 ALA A 114
VAL A  83
TRP A  82
 None
 0.81A 1nt5A-4d0qA:
undetectable		 1nt5A-4d0qA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ich TRANSCRIPTIONAL
REGULATOR

(Saccharomonospora
viridis) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		3 ALA A 147
VAL A 152
TRP A 194
 None
None
B3P  A 302 (-4.2A)
 0.86A 1nt5A-4ichA:
undetectable		 1nt5A-4ichA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		3 ALA A 100
VAL A  94
TRP A  37
 None
 0.86A 1nt5A-4inzA:
undetectable		 1nt5A-4inzA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lw4 CYSTEINE
DESULFURATION
PROTEIN CSDE

(Escherichia
coli) 		PF02657
(SufE) 		3 ALA C  59
VAL C  65
TRP C  66
 None
 0.91A 1nt5A-4lw4C:
undetectable		 1nt5A-4lw4C:
7.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Plesiocystis
pacifica) 		PF13561
(adh_short_C2) 		3 ALA A  78
VAL A  80
TRP A  42
 None
 0.87A 1nt5A-4nbwA:
undetectable		 1nt5A-4nbwA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oju HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN

(Pseudoflavonifractor
capillosus) 		PF13306
(LRR_5) 		3 ALA A  24
VAL A  26
TRP A  41
 None
 0.81A 1nt5A-4ojuA:
undetectable		 1nt5A-4ojuA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxn UNCHARACTERIZED
PROTEIN

(Zea mays) 		PF00171
(Aldedh) 		3 ALA A 176
VAL A 181
TRP A  73
 None
 0.88A 1nt5A-4pxnA:
undetectable		 1nt5A-4pxnA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.77A 1nt5A-4rgqA:
undetectable		 1nt5A-4rgqA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		3 ALA L  99
VAL L 472
TRP L 353
 None
 0.88A 1nt5A-4u9iL:
undetectable		 1nt5A-4u9iL:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		3 ALA A 125
VAL A 149
TRP A 150
 None
 0.78A 1nt5A-4w78A:
undetectable		 1nt5A-4w78A:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		3 ALA A   7
VAL A  13
TRP A  52
 None
 0.78A 1nt5A-4xiiA:
undetectable		 1nt5A-4xiiA:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xnv P2Y PURINOCEPTOR 1,
RUBREDOXIN, P2Y
PURINOCEPTOR 1

(Clostridium
pasteurianum;
Homo sapiens) 		PF00001
(7tm_1)
PF00301
(Rubredoxin) 		3 ALA A  72
VAL A  77
TRP A  83
 None
 0.88A 1nt5A-4xnvA:
undetectable		 1nt5A-4xnvA:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		3 ALA A 108
VAL A 102
TRP A  40
 None
 0.86A 1nt5A-4y9sA:
undetectable		 1nt5A-4y9sA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zdn AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		3 ALA A1125
VAL A1127
TRP A1130
 None
 0.76A 1nt5A-4zdnA:
undetectable		 1nt5A-4zdnA:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE

(Geobacillus
stearothermophilus) 		PF00232
(Glyco_hydro_1) 		3 ALA A 476
VAL A 470
TRP A  15
 None
 0.87A 1nt5A-4zfmA:
undetectable		 1nt5A-4zfmA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bov PUTATIVE EPOXIDE
HYDROLASE PROTEIN

(Klebsiella
pneumoniae) 		PF00561
(Abhydrolase_1) 		3 ALA A 155
VAL A 153
TRP A 157
 None
 0.90A 1nt5A-5bovA:
undetectable		 1nt5A-5bovA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		3 ALA A 145
VAL A 139
TRP A  65
 None
 0.85A 1nt5A-5d6oA:
undetectable		 1nt5A-5d6oA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		3 ALA A 149
VAL A 154
TRP A 164
 None
 0.76A 1nt5A-5dacA:
undetectable		 1nt5A-5dacA:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eo7 PREDICTED PROTEIN

(Aspergillus
oryzae) 		PF07938
(Fungal_lectin) 		3 ALA A 191
VAL A 178
TRP A 179
 None
 0.89A 1nt5A-5eo7A:
undetectable		 1nt5A-5eo7A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ete PRY1P

(Saccharomyces
cerevisiae) 		PF00188
(CAP) 		3 ALA A 225
VAL A 227
TRP A 230
 None
 0.90A 1nt5A-5eteA:
undetectable		 1nt5A-5eteA:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 3 ALA C 422
VAL C 424
TRP C 427
 None
 0.87A 1nt5A-5hr4C:
undetectable		 1nt5A-5hr4C:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hus TREHALOSE SYNTHASE
REGULATORY PROTEIN

(Candida
albicans) 		PF02358
(Trehalose_PPase) 		3 ALA A 244
VAL A 246
TRP A  14
 None
 0.83A 1nt5A-5husA:
undetectable		 1nt5A-5husA:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		3 ALA A 338
VAL A 336
TRP A 359
 None
 0.83A 1nt5A-5j44A:
undetectable		 1nt5A-5j44A:
1.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jys PROTEIN PRY1

(Saccharomyces
cerevisiae) 		PF00188
(CAP) 		3 ALA A 225
VAL A 227
TRP A 230
 None
 0.91A 1nt5A-5jysA:
undetectable		 1nt5A-5jysA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PUTATIVE PRE-MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		PF08084
(PROCT) 		3 ALA B2176
VAL B2174
TRP B2180
 None
 0.85A 1nt5A-5m59B:
undetectable		 1nt5A-5m59B:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 ALA A 362
VAL A 364
TRP A 369
 None
 0.61A 1nt5A-5mulA:
undetectable		 1nt5A-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvh BACCELL_00856

(Bacteroides
cellulosilyticus) 		PF15892
(BNR_4) 		3 ALA A 362
VAL A 364
TRP A 369
 None
 0.63A 1nt5A-5mvhA:
undetectable		 1nt5A-5mvhA:
2.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 3 ALA A 115
VAL A 117
TRP A 123
 None
 0.86A 1nt5A-5nmpA:
undetectable		 1nt5A-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nz7 CELLODEXTRIN
PHOSPHORYLASE

(Ruminiclostridium
thermocellum) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		3 ALA A 110
VAL A 112
TRP A 118
 None
 0.80A 1nt5A-5nz7A:
undetectable		 1nt5A-5nz7A:
1.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oie -

(-) 		no annotation 3 ALA A 439
VAL A 441
TRP A 444
 None
 0.85A 1nt5A-5oieA:
undetectable		 1nt5A-5oieA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tjj TRANSCRIPTIONAL
REGULATOR, ICLR
FAMILY

(Alicyclobacillus
acidocaldarius) 		PF01614
(IclR)
PF09339
(HTH_IclR) 		3 ALA A 245
VAL A 247
TRP A 250
 None
 0.85A 1nt5A-5tjjA:
undetectable		 1nt5A-5tjjA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uv2 (+)-LIMONENE
SYNTHASE

(Citrus sinensis) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		3 ALA A 370
VAL A 362
TRP A 365
 None
 0.81A 1nt5A-5uv2A:
undetectable		 1nt5A-5uv2A:
2.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5t ALPHA-KETOGLUTARIC
SEMIALDEHYDE
DEHYDROGENASE

(Azospirillum
brasilense) 		PF00171
(Aldedh) 		3 ALA A  67
VAL A  65
TRP A  62
 None
 0.84A 1nt5A-5x5tA:
undetectable		 1nt5A-5x5tA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		3 ALA A 241
VAL A 243
TRP A 201
 None
 0.89A 1nt5A-5xd0A:
undetectable		 1nt5A-5xd0A:
2.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 3 ALA A 104
VAL A  98
TRP A  40
 None
 0.82A 1nt5A-5xmdA:
undetectable		 1nt5A-5xmdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y35 -

(-) 		no annotation 3 ALA B 110
VAL B 112
TRP B 115
 None
 0.85A 1nt5A-5y35B:
undetectable		 1nt5A-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.88A 1nt5A-5zvs4:
undetectable		 1nt5A-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 3 ALA A  80
VAL A  71
TRP A  82
 None
 0.53A 1nt5A-6c7sA:
undetectable		 1nt5A-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d9y SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Paraburkholderia
phymatum) 		no annotation 3 ALA A  73
VAL A  75
TRP A  38
 None
 0.81A 1nt5A-6d9yA:
undetectable		 1nt5A-6d9yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A  40
VAL A  26
TRP A  27
 None
 0.79A 1nt5A-6f0qA:
undetectable		 1nt5A-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A  82
VAL A  68
TRP A  69
 None
 0.87A 1nt5A-6f0qA:
undetectable		 1nt5A-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A 166
VAL A 152
TRP A 153
 None
 0.85A 1nt5A-6f0qA:
undetectable		 1nt5A-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A 208
VAL A 194
TRP A 195
 None
 0.84A 1nt5A-6f0qA:
undetectable		 1nt5A-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A 250
VAL A 236
TRP A 237
 None
 0.90A 1nt5A-6f0qA:
undetectable		 1nt5A-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6h7x -

(-) 		no annotation 3 ALA A 278
VAL A 280
TRP A 283
 None
 0.86A 1nt5A-6h7xA:
undetectable		 1nt5A-6h7xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		3 ALA B 538
VAL B 534
TRP B 535
 None
 0.91A 1nt5A-6reqB:
undetectable		 1nt5A-6reqB:
4.18