SIMILAR PATTERNS OF AMINO ACIDS FOR 1NRM_B_DVAB6

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwu PROTEIN (AGGLUTININ)

(Allium sativum) 		PF01453
(B_lectin) 		3 ALA Q  55
VAL Q  64
TRP Q  74
 None
 0.93A 1nrmB-1bwuQ:
undetectable		 1nrmB-1bwuQ:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE

(Pagrus major) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ALA A 276
VAL A 278
TRP A 175
 None
 0.88A 1nrmB-1g0dA:
undetectable		 1nrmB-1g0dA:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ALA A 284
VAL A 286
TRP A 248
 None
 0.92A 1nrmB-1hcyA:
undetectable		 1nrmB-1hcyA:
2.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3b ATP-DEPENDENT
PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Thermus
thermophilus) 		PF01293
(PEPCK_ATP) 		3 ALA A 349
VAL A 352
TRP A 489
 None
 0.88A 1nrmB-1j3bA:
undetectable		 1nrmB-1j3bA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ALA A 299
VAL A 304
TRP A   3
 None
 0.86A 1nrmB-1ml4A:
undetectable		 1nrmB-1ml4A:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ALA A 223
VAL A 234
TRP A 160
 CA  A 601 ( 4.9A)
None
None
 0.96A 1nrmB-1ot5A:
undetectable		 1nrmB-1ot5A:
3.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		3 ALA A 218
VAL A 228
TRP A 156
 None
 0.89A 1nrmB-1r6vA:
undetectable		 1nrmB-1r6vA:
6.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ALA A  15
VAL A  17
TRP A  66
 None
 0.84A 1nrmB-1rblA:
undetectable		 1nrmB-1rblA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfo WHISKER ANTIGEN
CONTROL PROTEIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 ALA A  12
VAL A  21
TRP A  20
 None
 0.70A 1nrmB-1rfoA:
undetectable		 1nrmB-1rfoA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfr ANTIGEN 85-A

(Mycobacterium
tuberculosis) 		PF00756
(Esterase) 		3 ALA A 129
VAL A 123
TRP A  51
 None
 0.69A 1nrmB-1sfrA:
undetectable		 1nrmB-1sfrA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		3 ALA B 183
VAL B 188
TRP B 191
 None
 0.90A 1nrmB-1ta3B:
undetectable		 1nrmB-1ta3B:
4.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ALA A 423
VAL A 453
TRP A 465
 None
 0.96A 1nrmB-1tkcA:
undetectable		 1nrmB-1tkcA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 ALA A  36
VAL A  33
TRP A  34
 PGO  A 604 ( 3.9A)
PGO  A 604 (-4.8A)
None
 0.89A 1nrmB-1womA:
undetectable		 1nrmB-1womA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wom SIGMA FACTOR SIGB
REGULATION PROTEIN
RSBQ

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		3 ALA A  99
VAL A  93
TRP A  34
 None
 0.88A 1nrmB-1womA:
undetectable		 1nrmB-1womA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xup GLYCEROL KINASE

(Enterococcus
casseliflavus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA O  62
VAL O  57
TRP O  54
 None
 0.93A 1nrmB-1xupO:
undetectable		 1nrmB-1xupO:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xvx YFUA

(Yersinia
enterocolitica) 		PF13343
(SBP_bac_6) 		3 ALA A  66
VAL A  68
TRP A  98
 None
 0.95A 1nrmB-1xvxA:
undetectable		 1nrmB-1xvxA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 ALA A 402
VAL A 325
TRP A 322
 None
 0.88A 1nrmB-2c4mA:
undetectable		 1nrmB-2c4mA:
3.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		3 ALA A 227
VAL A 248
TRP A 250
 None
 0.95A 1nrmB-2cuyA:
undetectable		 1nrmB-2cuyA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4w GLYCEROL KINASE

(Cellulomonas
sp.) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  99
VAL A  87
TRP A  88
 None
 0.88A 1nrmB-2d4wA:
undetectable		 1nrmB-2d4wA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3j EPOXIDE HYDROLASE
EPHB

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		3 ALA A 107
VAL A 101
TRP A  43
 None
 0.92A 1nrmB-2e3jA:
undetectable		 1nrmB-2e3jA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gen PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		3 ALA A 192
VAL A 190
TRP A 187
 None
 0.66A 1nrmB-2genA:
undetectable		 1nrmB-2genA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		3 ALA A 186
VAL A 158
TRP A 182
 None
 0.90A 1nrmB-2horA:
undetectable		 1nrmB-2horA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2in3 HYPOTHETICAL PROTEIN

(Nitrosomonas
europaea) 		PF01323
(DSBA) 		3 ALA A 119
VAL A 122
TRP A  20
 None
 0.81A 1nrmB-2in3A:
undetectable		 1nrmB-2in3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jep XYLOGLUCANASE

(Paenibacillus
pabuli) 		PF00150
(Cellulase) 		3 ALA A  54
VAL A  90
TRP A 108
 None
 0.86A 1nrmB-2jepA:
undetectable		 1nrmB-2jepA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgp TYROCIDINE
SYNTHETASE 3

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		3 ALA A  32
VAL A  30
TRP A  21
 None
 0.94A 1nrmB-2jgpA:
undetectable		 1nrmB-2jgpA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psf RENILLA-LUCIFERIN
2-MONOOXYGENASE

(Renilla
reniformis) 		PF00561
(Abhydrolase_1) 		3 ALA A 123
VAL A 117
TRP A  60
 None
 0.91A 1nrmB-2psfA:
undetectable		 1nrmB-2psfA:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 ALA A 281
VAL A 283
TRP A 180
 None
 0.87A 1nrmB-2q3zA:
undetectable		 1nrmB-2q3zA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v72 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF00754
(F5_F8_type_C) 		3 ALA A  64
VAL A 106
TRP A  97
 None
 0.76A 1nrmB-2v72A:
undetectable		 1nrmB-2v72A:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vak SIGMA A

(Avian
orthoreovirus) 		PF03084
(Sigma_1_2) 		3 ALA A  83
VAL A  85
TRP A 105
 None
 0.78A 1nrmB-2vakA:
undetectable		 1nrmB-2vakA:
5.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8q SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00171
(Aldedh) 		3 ALA A 117
VAL A 115
TRP A 112
 None
 0.93A 1nrmB-2w8qA:
undetectable		 1nrmB-2w8qA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		3 ALA A 246
VAL A 200
TRP A 227
 None
 0.93A 1nrmB-2xdqA:
undetectable		 1nrmB-2xdqA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xrm INTRACELLULAR
SUBTILISIN PROTEASE

(Bacillus
clausii) 		PF00082
(Peptidase_S8) 		3 ALA A  96
VAL A 106
TRP A  34
 None
 0.96A 1nrmB-2xrmA:
undetectable		 1nrmB-2xrmA:
4.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2x TK-SUBTILISIN

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		3 ALA A 163
VAL A 173
TRP A  99
 None
 0.84A 1nrmB-2z2xA:
undetectable		 1nrmB-2z2xA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		3 ALA A 163
VAL A 173
TRP A  99
 None
 0.81A 1nrmB-2z2zA:
undetectable		 1nrmB-2z2zA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhi CARBONYL REDUCTASE
[NADPH] 1

(Homo sapiens) 		PF00106
(adh_short) 		3 ALA A 224
VAL A 202
TRP A 276
 None
 0.95A 1nrmB-3bhiA:
undetectable		 1nrmB-3bhiA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwn L-TRYPTOPHAN
AMINOTRANSFERASE

(Arabidopsis
thaliana) 		PF04864
(Alliinase_C) 		3 ALA A 150
VAL A 122
TRP A 146
 None
 0.95A 1nrmB-3bwnA:
undetectable		 1nrmB-3bwnA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cin MYO-INOSITOL-1-PHOSP
HATE
SYNTHASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		3 ALA A 111
VAL A 116
TRP A 119
 None
 0.92A 1nrmB-3cinA:
undetectable		 1nrmB-3cinA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmg PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		3 ALA A 651
VAL A 658
TRP A 659
 None
 0.89A 1nrmB-3cmgA:
undetectable		 1nrmB-3cmgA:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxh CYTOCHROME B-C1
COMPLEX SUBUNIT 9

(Saccharomyces
cerevisiae) 		PF05365
(UCR_UQCRX_QCR9) 		3 ALA I  57
VAL I  52
TRP I  49
 None
 0.93A 1nrmB-3cxhI:
undetectable		 1nrmB-3cxhI:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		3 ALA A  90
VAL A  84
TRP A  28
 None
 0.90A 1nrmB-3e3aA:
undetectable		 1nrmB-3e3aA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		3 ALA A  81
VAL A  60
TRP A 157
 None
 0.91A 1nrmB-3fqdA:
undetectable		 1nrmB-3fqdA:
2.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A  99
VAL A  87
TRP A  88
 None
 0.93A 1nrmB-3g25A:
undetectable		 1nrmB-3g25A:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 ALA A 367
VAL A 372
TRP A 342
 GOL  A 705 ( 3.8A)
None
None
 0.85A 1nrmB-3m49A:
undetectable		 1nrmB-3m49A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p3l CYTOCHROME P450

(Streptomyces
thioluteus) 		PF00067
(p450) 		3 ALA A 319
VAL A 321
TRP A  26
 None
 0.83A 1nrmB-3p3lA:
undetectable		 1nrmB-3p3lA:
3.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ALA A 353
VAL A 355
TRP A 358
 None
 0.82A 1nrmB-3qldA:
undetectable		 1nrmB-3qldA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sz3 TRYPTOPHANYL-TRNA
SYNTHETASE

(Vibrio cholerae) 		PF00579
(tRNA-synt_1b) 		3 ALA A  69
VAL A  72
TRP A  28
 None
 0.75A 1nrmB-3sz3A:
undetectable		 1nrmB-3sz3A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tef IRON(III) ABC
TRANSPORTER,
PERIPLASMIC
IRON-COMPOUND-BINDIN
G PROTEIN

(Vibrio cholerae) 		PF01497
(Peripla_BP_2) 		3 ALA A 302
VAL A 268
TRP A 309
 None
 0.96A 1nrmB-3tefA:
undetectable		 1nrmB-3tefA:
4.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti7 BASIC EXTRACELLULAR
SUBTILISIN-LIKE
PROTEASE BPRV

(Dichelobacter
nodosus) 		PF00082
(Peptidase_S8) 		3 ALA A 115
VAL A 126
TRP A  26
 None
 0.94A 1nrmB-3ti7A:
undetectable		 1nrmB-3ti7A:
5.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		3 ALA A  91
VAL A  85
TRP A  29
 None
 0.88A 1nrmB-3v48A:
undetectable		 1nrmB-3v48A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		3 ALA A 114
VAL A 125
TRP A  34
 None
 0.91A 1nrmB-3vv3A:
undetectable		 1nrmB-3vv3A:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		3 ALA A 169
VAL A 210
TRP A 228
 None
 0.83A 1nrmB-3zmrA:
undetectable		 1nrmB-3zmrA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1j GLYCEROL KINASE

(Sinorhizobium
meliloti) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 ALA A 122
VAL A 110
TRP A 111
 None
 0.89A 1nrmB-4e1jA:
undetectable		 1nrmB-4e1jA:
2.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inz SOLUBLE EPOXIDE
HYDROLASE

(Bacillus
megaterium) 		PF00561
(Abhydrolase_1) 		3 ALA A 100
VAL A  94
TRP A  37
 None
 0.90A 1nrmB-4inzA:
undetectable		 1nrmB-4inzA:
2.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		3 ALA A 287
VAL A 282
TRP A 279
 ALA  A 287 ( 0.0A)
VAL  A 282 ( 0.6A)
TRP  A 279 ( 0.5A)
 0.91A 1nrmB-4jbeA:
undetectable		 1nrmB-4jbeA:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjj CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Thermobifida
fusca) 		PF02011
(Glyco_hydro_48) 		3 ALA A 622
VAL A 501
TRP A 420
 None
 0.96A 1nrmB-4jjjA:
undetectable		 1nrmB-4jjjA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ly4 PEPTIDOGLYCAN
DEACETYLASE

(Helicobacter
pylori) 		PF01522
(Polysacc_deac_1) 		3 ALA A  57
VAL A 276
TRP A 275
 None
 0.69A 1nrmB-4ly4A:
undetectable		 1nrmB-4ly4A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkv RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Pisum sativum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ALA A  15
VAL A  17
TRP A  66
 None
 0.73A 1nrmB-4mkvA:
undetectable		 1nrmB-4mkvA:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mtp RNA DEPENDENT RNA
POLYMERASE

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5) 		3 ALA A 628
VAL A 631
TRP A 651
 ALA  A 628 ( 0.0A)
VAL  A 631 ( 0.6A)
TRP  A 651 ( 0.5A)
 0.96A 1nrmB-4mtpA:
undetectable		 1nrmB-4mtpA:
2.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1c TOLUENE-4-MONOOXYGEN
ASE SYSTEM PROTEIN A

(Pseudomonas
mendocina) 		PF02332
(Phenol_Hydrox) 		3 ALA A 489
VAL A 350
TRP A 336
 None
 0.96A 1nrmB-4p1cA:
undetectable		 1nrmB-4p1cA:
4.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pob THIOREDOXIN

(Mycobacteroides
abscessus) 		PF00085
(Thioredoxin) 		3 ALA A  64
VAL A  62
TRP A  30
 None
 0.94A 1nrmB-4pobA:
undetectable		 1nrmB-4pobA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgq GLYCEROL-1-PHOSPHATE
DEHYDROGENASE

(Methanocaldococcus
jannaschii) 		PF13685
(Fe-ADH_2) 		3 ALA A 221
VAL A 156
TRP A 159
 K  A 402 ( 3.6A)
None
None
 0.67A 1nrmB-4rgqA:
undetectable		 1nrmB-4rgqA:
3.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0h METALLO-BETA-LACTAMA
SE DOMAIN-CONTAINING
PROTEIN 1 1

(Homo sapiens) 		PF00753
(Lactamase_B) 		3 ALA A 183
VAL A 191
TRP A 167
 None
 0.93A 1nrmB-4v0hA:
undetectable		 1nrmB-4v0hA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1

(Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N) 		3 ALA A 125
VAL A 149
TRP A 150
 None
 0.91A 1nrmB-4w78A:
undetectable		 1nrmB-4w78A:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w87 XYLOGLUCAN-SPECIFIC
ENDO-BETA-1,4-GLUCAN
ASE

(uncultured
bacterium) 		PF00150
(Cellulase) 		3 ALA A 115
VAL A 153
TRP A 171
 None
 0.91A 1nrmB-4w87A:
undetectable		 1nrmB-4w87A:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4weo PUTATIVE
ACETOIN(DIACETYL)
REDUCTASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		3 ALA A 116
VAL A 111
TRP A 108
 None
 0.82A 1nrmB-4weoA:
undetectable		 1nrmB-4weoA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 3 ALA E 404
VAL E 397
TRP E 296
 None
 0.93A 1nrmB-4whbE:
undetectable		 1nrmB-4whbE:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		3 ALA A 108
VAL A 102
TRP A  40
 None
 0.90A 1nrmB-4y9sA:
undetectable		 1nrmB-4y9sA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzt CELLULOSE HYDROLASE

(Bacillus
licheniformis) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		3 ALA A  40
VAL A  72
TRP A  90
 None
 0.95A 1nrmB-4yztA:
undetectable		 1nrmB-4yztA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		3 ALA A  73
VAL A  71
TRP A  55
 None
 0.91A 1nrmB-5a3yA:
undetectable		 1nrmB-5a3yA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x LOW DENSITY
LIPOPROTEIN
RECEPTOR-RELATED
PROTEIN 8,
APOLIPOPROTEIN E
RECEPTOR, ISOFORM
CRA_E

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00058
(Ldl_recept_b)
PF07645
(EGF_CA)
PF14670
(FXa_inhibition) 		3 ALA B 433
VAL B 449
TRP B 470
 None
 0.94A 1nrmB-5b4xB:
undetectable		 1nrmB-5b4xB:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2m PREDICTED PROTEIN

(Nematostella
vectensis) 		PF14517
(Tachylectin) 		3 ALA A  36
VAL A 232
TRP A 237
 None
 0.92A 1nrmB-5c2mA:
undetectable		 1nrmB-5c2mA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c59 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Escherichia
coli) 		PF12704
(MacB_PCD) 		3 ALA A  52
VAL A 180
TRP A  48
 None
 0.91A 1nrmB-5c59A:
undetectable		 1nrmB-5c59A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dac PUTATIVE
UNCHARACTERIZED
PROTEIN,PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF13476
(AAA_23) 		3 ALA A 149
VAL A 154
TRP A 164
 None
 0.79A 1nrmB-5dacA:
undetectable		 1nrmB-5dacA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fxn THERMOLYSIN

(Bacillus
thermoproteolyticus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		3 ALA A  73
VAL A  71
TRP A  55
 None
 0.91A 1nrmB-5fxnA:
undetectable		 1nrmB-5fxnA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.90A 1nrmB-5gheA:
undetectable		 1nrmB-5gheA:
2.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnx BETA-GLUCOSIDASE

(metagenome) 		PF00232
(Glyco_hydro_1) 		3 ALA A 198
VAL A 196
TRP A 253
 None
 0.90A 1nrmB-5gnxA:
undetectable		 1nrmB-5gnxA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h0u MATRIX
METALLOPROTEINASE-14

(Homo sapiens) 		PF00413
(Peptidase_M10) 		3 ALA A 154
VAL A 150
TRP A 151
 None
 0.96A 1nrmB-5h0uA:
undetectable		 1nrmB-5h0uA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h98 GEOBACTER
METALLIREDUCENS
SMUG1

(Geobacter
metallireducens) 		no annotation 3 ALA A 135
VAL A  69
TRP A 115
 None
 0.85A 1nrmB-5h98A:
undetectable		 1nrmB-5h98A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		3 ALA A 670
VAL A 666
TRP A 685
 None
 0.93A 1nrmB-5kdxA:
undetectable		 1nrmB-5kdxA:
3.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 3 ALA A 113
VAL A 373
TRP A 370
 None
 0.92A 1nrmB-5kucA:
undetectable		 1nrmB-5kucA:
2.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		3 ALA A 362
VAL A 364
TRP A 369
 None
 0.93A 1nrmB-5mulA:
undetectable		 1nrmB-5mulA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nmp ISATIN HYDROLASE

(Ralstonia
solanacearum) 		no annotation 3 ALA A 115
VAL A 117
TRP A 123
 None
 0.86A 1nrmB-5nmpA:
undetectable		 1nrmB-5nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 ALA A  16
VAL A  18
TRP A  68
 None
 0.86A 1nrmB-5nv3A:
undetectable		 1nrmB-5nv3A:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oyd CELLULASE, PUTATIVE,
CEL5D

(Cellvibrio
japonicus) 		no annotation 3 ALA A 136
VAL A 168
TRP A 185
 None
 0.71A 1nrmB-5oydA:
undetectable		 1nrmB-5oydA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdg FUSION GLYCOPROTEIN
F0,FIBRITIN

(Bovine
orthopneumovirus;
Enterobacteria
phage T4 sensu
lato) 		PF00523
(Fusion_gly)
PF07921
(Fibritin_C) 		3 ALA A 529
VAL A 538
TRP A 537
 None
 0.89A 1nrmB-5tdgA:
undetectable		 1nrmB-5tdgA:
2.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		3 ALA A 274
VAL A 272
TRP A 277
 None
 0.95A 1nrmB-5uakA:
undetectable		 1nrmB-5uakA:
1.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		3 ALA A 147
VAL A 133
TRP A 140
 None
 0.89A 1nrmB-5ubkA:
undetectable		 1nrmB-5ubkA:
1.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2m MEVALONATE
DIPHOSPHATE
DECARBOXYLASE

(Enterococcus
faecalis) 		no annotation 3 ALA A 249
VAL A 199
TRP A  18
 None
 0.66A 1nrmB-5v2mA:
undetectable		 1nrmB-5v2mA:
4.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgs LACHRYMATORY-FACTOR
SYNTHASE

(Allium cepa) 		PF10604
(Polyketide_cyc2) 		3 ALA A  27
VAL A  25
TRP A 133
 None
None
9A7  A 202 (-3.4A)
 0.93A 1nrmB-5vgsA:
undetectable		 1nrmB-5vgsA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wsl KERATINASE

(Meiothermus
taiwanensis) 		no annotation 3 ALA A  55
VAL A  96
TRP A 116
 None
 0.92A 1nrmB-5wslA:
undetectable		 1nrmB-5wslA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		3 ALA A 241
VAL A 243
TRP A 201
 None
 0.85A 1nrmB-5xd0A:
undetectable		 1nrmB-5xd0A:
2.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 3 ALA A 104
VAL A  98
TRP A  40
 None
 0.90A 1nrmB-5xmdA:
undetectable		 1nrmB-5xmdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zgb LHCR3

(Cyanidioschyzon
merolae) 		no annotation 3 ALA 3 114
VAL 3 119
TRP 3  47
 None
None
CLA  3 208 (-3.4A)
 0.92A 1nrmB-5zgb3:
undetectable		 1nrmB-5zgb3:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 3 ALA 4 243
VAL 4 248
TRP 4 257
 None
 0.73A 1nrmB-5zvs4:
undetectable		 1nrmB-5zvs4:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 3 ALA A  80
VAL A  71
TRP A  82
 None
 0.77A 1nrmB-6c7sA:
undetectable		 1nrmB-6c7sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck0 BIOTIN ACETYL
COENZYME A
CARBOXYLASE
SYNTHETASE

(Helicobacter
pylori) 		no annotation 3 ALA A 170
VAL A 165
TRP A 162
 None
 0.94A 1nrmB-6ck0A:
undetectable		 1nrmB-6ck0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0q PIZZA6-AYW

(synthetic
construct) 		no annotation 3 ALA A  82
VAL A  68
TRP A  69
 None
 0.93A 1nrmB-6f0qA:
undetectable		 1nrmB-6f0qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 3 ALA A  96
VAL A 107
TRP A  34
 NA  A 402 ( 4.7A)
None
None
 0.90A 1nrmB-6f9mA:
undetectable		 1nrmB-6f9mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy6 -

(-) 		no annotation 3 ALA B 312
VAL B 307
TRP B 308
 None
 0.89A 1nrmB-6gy6B:
undetectable		 1nrmB-6gy6B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6req PROTEIN
(METHYLMALONYL-COA
MUTASE)

(Propionibacterium
freudenreichii) 		PF01642
(MM_CoA_mutase) 		3 ALA B 538
VAL B 534
TRP B 535
 None
 0.72A 1nrmB-6reqB:
undetectable		 1nrmB-6reqB:
4.88