SIMILAR PATTERNS OF AMINO ACIDS FOR 1NR6_A_DIFA501_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 179
GLY A 230
ALA A  22
LEU A 389
LEU A 176
 None
 1.17A 1nr6A-1ee0A:
undetectable		 1nr6A-1ee0A:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 LEU A 127
GLY A 122
ALA A 210
LEU A 302
LEU A 304
 None
 1.06A 1nr6A-1gz7A:
undetectable		 1nr6A-1gz7A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idm 3-ISOPROPYLMALATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 LEU A 290
GLY A 253
LEU A 110
LEU A 317
PHE A 107
 None
 1.08A 1nr6A-1idmA:
undetectable		 1nr6A-1idmA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		no annotation 5 LEU B 293
ALA B 290
GLY B 272
LEU B 326
PHE B 321
 None
 1.07A 1nr6A-1jmzB:
undetectable		 1nr6A-1jmzB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		5 ALA A 115
PHE A 111
GLY A  42
ALA A  41
LEU A 127
 None
 1.05A 1nr6A-1jneA:
undetectable		 1nr6A-1jneA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqb NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A1305
GLY A1185
ALA A1184
LEU A1319
LEU A1316
 None
 0.94A 1nr6A-1jqbA:
undetectable		 1nr6A-1jqbA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Aeropyrum
pernix) 		PF01791
(DeoC) 		5 ALA A 135
GLY A 102
ALA A 103
THR A  61
LEU A 106
 None
 0.88A 1nr6A-1n7kA:
undetectable		 1nr6A-1n7kA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
BETA SUBUNIT

(Saccharomyces
cerevisiae) 		PF09439
(SRPRB) 		5 LEU B 112
ALA B 152
GLY B  45
THR B 128
LEU B 171
 None
 1.08A 1nr6A-1nrjB:
undetectable		 1nr6A-1nrjB:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ode CHORISMATE MUTASE

(Thermus
thermophilus) 		PF07736
(CM_1) 		5 LEU A  72
PHE A  47
ALA A  92
LEU A  31
LEU A  27
 None
 1.09A 1nr6A-1odeA:
undetectable		 1nr6A-1odeA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		5 LEU A 343
ALA A  88
GLY A 325
LEU A 118
PHE A  61
 None
 1.05A 1nr6A-1oltA:
undetectable		 1nr6A-1oltA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Pseudomonas
putida) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A  35
PHE A  31
GLY A 194
LEU A 221
LEU A 190
 None
 0.98A 1nr6A-1re5A:
undetectable		 1nr6A-1re5A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sh8 HYPOTHETICAL PROTEIN
PA5026

(Pseudomonas
aeruginosa) 		PF14539
(DUF4442) 		5 ALA A  99
GLY A  64
ALA A  65
THR A  12
LEU A  24
 None
 1.14A 1nr6A-1sh8A:
undetectable		 1nr6A-1sh8A:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txd RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 12

(Homo sapiens) 		PF00621
(RhoGEF) 		5 LEU A 943
ALA A 964
ALA A 948
THR A 951
LEU A 868
 None
 1.03A 1nr6A-1txdA:
undetectable		 1nr6A-1txdA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ur1 ENDOXYLANASE

(Cellvibrio
mixtus) 		PF00331
(Glyco_hydro_10) 		5 PHE A  61
GLY A 329
LEU A 356
LEU A  56
PHE A 352
 None
 1.08A 1nr6A-1ur1A:
undetectable		 1nr6A-1ur1A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 174
GLY A 225
ALA A  17
LEU A 384
LEU A 171
 None
 1.12A 1nr6A-1z1eA:
undetectable		 1nr6A-1z1eA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3x IRON-RESPONSIVE
ELEMENT BINDING
PROTEIN 1

(Homo sapiens) 		PF00330
(Aconitase)
PF00694
(Aconitase_C) 		5 ALA A 453
GLY A 448
ALA A 449
LEU A 471
LEU A 491
 None
 1.16A 1nr6A-2b3xA:
undetectable		 1nr6A-2b3xA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw2 SUPEROXIDE DISMUTASE
1

(Perkinsus
marinus) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 LEU A 102
ALA A 134
GLY A 200
ALA A 199
LEU A 158
 None
 1.01A 1nr6A-2cw2A:
undetectable		 1nr6A-2cw2A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284

(Pyrococcus
horikoshii) 		PF06745
(ATPase) 		5 ALA A 123
GLY A  54
ALA A 129
LEU A 159
LEU A 120
 None
 1.13A 1nr6A-2dr3A:
undetectable		 1nr6A-2dr3A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		5 LEU A 223
PHE A 224
GLY A 241
LEU A  75
LEU A  79
 None
 1.06A 1nr6A-2e54A:
undetectable		 1nr6A-2e54A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3b PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 LEU A 146
ALA A 152
THR A 156
LEU A  84
LEU A  80
 None
 1.00A 1nr6A-2g3bA:
undetectable		 1nr6A-2g3bA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gou OXIDOREDUCTASE,
FMN-BINDING

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 LEU A   5
GLY A  52
ALA A  51
LEU A 331
PHE A 321
 None
 1.16A 1nr6A-2gouA:
undetectable		 1nr6A-2gouA:
22.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		5 PHE A 125
GLY A 316
ALA A 317
THR A 321
LEU A 382
 None
BHF  A 800 (-3.8A)
HEM  A 900 ( 3.5A)
HEM  A 900 ( 3.1A)
HEM  A 900 (-4.0A)
 0.70A 1nr6A-2hi4A:
42.6		 1nr6A-2hi4A:
31.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2him L-ASPARAGINASE 1

(Escherichia
coli) 		PF00710
(Asparaginase) 		5 LEU A  35
PHE A  41
GLY A 128
THR A 115
LEU A 136
 None
 1.05A 1nr6A-2himA:
undetectable		 1nr6A-2himA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6x HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Porphyromonas
gingivalis) 		PF13419
(HAD_2) 		5 PHE A  92
GLY A  10
THR A 110
LEU A 115
LEU A 130
 None
 1.16A 1nr6A-2i6xA:
undetectable		 1nr6A-2i6xA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixs SDAI RESTRICTION
ENDONUCLEASE

(Streptomyces
diastaticus) 		PF06616
(BsuBI_PstI_RE) 		5 GLY A 274
ALA A 273
THR A 270
LEU A 223
PHE A 268
 None
 1.10A 1nr6A-2ixsA:
undetectable		 1nr6A-2ixsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oo4 NEUROGENIC LOCUS
NOTCH HOMOLOG
PROTEIN 2

(Homo sapiens) 		PF00066
(Notch)
PF06816
(NOD)
PF07684
(NODP) 		5 LEU A1625
ALA A1646
GLY A1570
LEU A1659
LEU A1650
 None
None
GOL  A7007 ( 3.7A)
None
None
 1.15A 1nr6A-2oo4A:
undetectable		 1nr6A-2oo4A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg4 UNCHARACTERIZED
PROTEIN

(Aeropyrum
pernix) 		no annotation 5 LEU A  72
GLY A  58
THR A   5
LEU A  13
LEU A  17
 None
 0.91A 1nr6A-2pg4A:
undetectable		 1nr6A-2pg4A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5e CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 2

(Homo sapiens) 		PF03031
(NIF) 		5 LEU A 156
PHE A 157
GLY A 257
ALA A 258
LEU A 268
 None
 0.99A 1nr6A-2q5eA:
undetectable		 1nr6A-2q5eA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q88 PUTATIVE ABC
TRANSPORTER AMINO
ACID-BINDING PROTEIN

(Sinorhizobium
meliloti) 		PF00497
(SBP_bac_3) 		5 LEU A  96
ALA A 204
ALA A  41
LEU A 224
PHE A 230
 None
 1.08A 1nr6A-2q88A:
undetectable		 1nr6A-2q88A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q88 PUTATIVE ABC
TRANSPORTER AMINO
ACID-BINDING PROTEIN

(Sinorhizobium
meliloti) 		PF00497
(SBP_bac_3) 		5 LEU A  96
ALA A 204
LEU A 224
LEU A 221
PHE A 230
 None
 1.11A 1nr6A-2q88A:
undetectable		 1nr6A-2q88A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybu ACIDIC MAMMALIAN
CHITINASE

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		5 PHE A 119
GLY A  60
ALA A  59
LEU A 135
PHE A 137
 None
 1.16A 1nr6A-2ybuA:
undetectable		 1nr6A-2ybuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 184
GLY A 235
ALA A  27
LEU A 394
LEU A 181
 None
 1.12A 1nr6A-3awkA:
undetectable		 1nr6A-3awkA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9j XANTHINE OXIDASE

(Bos taurus) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		5 LEU B 452
ALA B 466
GLY B 437
LEU B 490
PHE B 516
 None
 1.10A 1nr6A-3b9jB:
undetectable		 1nr6A-3b9jB:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3baz HYDROXYPHENYLPYRUVAT
E REDUCTASE

(Plectranthus
scutellarioides) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A 221
ALA A 244
GLY A 251
LEU A 255
LEU A 241
 None
 1.12A 1nr6A-3bazA:
undetectable		 1nr6A-3bazA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		5 ALA A 210
PHE A 259
GLY A 192
LEU A 202
PHE A 200
 None
 1.06A 1nr6A-3bptA:
undetectable		 1nr6A-3bptA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		5 LEU A 376
ALA A 358
ALA A 333
LEU A 322
LEU A 342
 None
 1.11A 1nr6A-3bz5A:
undetectable		 1nr6A-3bz5A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyj MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Rubrobacter
xylanophilus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 230
ALA A 202
GLY A 195
ALA A 193
LEU A 218
 None
 1.06A 1nr6A-3cyjA:
undetectable		 1nr6A-3cyjA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3l ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Homo sapiens) 		PF00305
(Lipoxygenase) 		5 ALA A 510
PHE A 515
GLY A 506
LEU A 362
LEU A 436
 None
 1.11A 1nr6A-3d3lA:
undetectable		 1nr6A-3d3lA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3da8 PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN

(Mycobacterium
tuberculosis) 		PF00551
(Formyl_trans_N) 		5 LEU A   5
ALA A 206
GLY A 198
LEU A 115
LEU A 148
 None
 1.12A 1nr6A-3da8A:
undetectable		 1nr6A-3da8A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6w XRE-FAMILY LIKE
PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF13560
(HTH_31) 		5 ALA A  19
GLY A  62
LEU A  51
LEU A  16
PHE A  56
 None
 1.08A 1nr6A-3f6wA:
undetectable		 1nr6A-3f6wA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 305
GLY A 185
ALA A 184
LEU A 319
LEU A 316
 None
 0.95A 1nr6A-3fplA:
undetectable		 1nr6A-3fplA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 5 LEU B 114
ALA B 131
GLY B  96
LEU B 156
LEU B 159
 None
 1.13A 1nr6A-3jruB:
undetectable		 1nr6A-3jruB:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl9 GLUTAMYL
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF05343
(Peptidase_M42) 		5 ALA A  64
GLY A 219
ALA A 220
LEU A  62
PHE A 227
 None
 0.90A 1nr6A-3kl9A:
undetectable		 1nr6A-3kl9A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 227
GLY A 234
ALA A 233
LEU A 265
LEU A 269
 None
 1.11A 1nr6A-3mvjA:
undetectable		 1nr6A-3mvjA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		5 LEU A 339
PHE A 335
GLY A 573
LEU A 293
LEU A 541
 None
 1.02A 1nr6A-3pieA:
undetectable		 1nr6A-3pieA:
17.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pm0 CYTOCHROME P450 1B1

(Homo sapiens) 		PF00067
(p450) 		5 ALA A 133
PHE A 134
GLY A 329
ALA A 330
THR A 334
 HEM  A 900 (-3.3A)
BHF  A 800 (-4.8A)
BHF  A 800 ( 4.0A)
HEM  A 900 ( 3.4A)
HEM  A 900 ( 3.2A)
 0.80A 1nr6A-3pm0A:
41.5		 1nr6A-3pm0A:
35.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q98 TRANSCARBAMYLASE

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A  35
ALA A 174
LEU A 186
LEU A 183
PHE A 218
 None
 1.01A 1nr6A-3q98A:
undetectable		 1nr6A-3q98A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Thermomonospora
curvata) 		PF10021
(DUF2263) 		5 LEU A  94
ALA A 209
LEU A 242
LEU A 206
PHE A 238
 None
 1.11A 1nr6A-3sigA:
undetectable		 1nr6A-3sigA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3skd PUTATIVE
UNCHARACTERIZED
PROTEIN TTHB187

(Thermus
thermophilus) 		no annotation 5 LEU A  33
ALA A  64
GLY A 177
ALA A 178
LEU A  53
 None
 1.00A 1nr6A-3skdA:
undetectable		 1nr6A-3skdA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6s CERJ

(Streptomyces
tendae) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 LEU A  80
GLY A 121
THR A 185
LEU A   6
LEU A 173
 None
 1.13A 1nr6A-3t6sA:
undetectable		 1nr6A-3t6sA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 LEU A 393
ALA A 309
ALA A 284
LEU A 423
PHE A 155
 None
 1.17A 1nr6A-3tktA:
30.7		 1nr6A-3tktA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 641
PHE A 557
GLY A 688
LEU A 626
LEU A 630
 None
 0.99A 1nr6A-3viuA:
undetectable		 1nr6A-3viuA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vz0 PUTATIVE
NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF00171
(Aldedh) 		5 PHE A 257
GLY A 332
ALA A 331
LEU A 281
LEU A 284
 None
 1.03A 1nr6A-3vz0A:
undetectable		 1nr6A-3vz0A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ALA A 174
GLY A 225
ALA A  17
LEU A 384
LEU A 171
 ALA  A 174 ( 0.0A)
GLY  A 225 ( 0.0A)
ALA  A  17 ( 0.0A)
LEU  A 384 ( 0.6A)
LEU  A 171 ( 0.5A)
 1.17A 1nr6A-3wd7A:
undetectable		 1nr6A-3wd7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Flaveria
pringlei) 		PF00311
(PEPcase) 		5 LEU A 376
GLY A 370
LEU A 430
LEU A 410
PHE A 433
 None
 1.16A 1nr6A-3zgbA:
undetectable		 1nr6A-3zgbA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5a NUCLEOSIDE-TRIPHOSPH
ATASE 1

(Toxoplasma
gondii) 		PF01150
(GDA1_CD39) 		5 GLY A  72
ALA A  71
LEU A 152
LEU A 156
PHE A 109
 ANP  A 700 (-3.6A)
None
None
None
None
 1.02A 1nr6A-4a5aA:
undetectable		 1nr6A-4a5aA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cob KYNURENINE
FORMAMIDASE

(Pseudomonas
aeruginosa) 		PF04199
(Cyclase) 		5 LEU A 177
ALA A 204
GLY A 174
LEU A 142
LEU A 187
 None
 1.14A 1nr6A-4cobA:
undetectable		 1nr6A-4cobA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvc ALCOHOL
DEHYDROGENASE

(Pseudogluconobacter
saccharoketogenes) 		PF13360
(PQQ_2) 		5 ALA A 537
PHE A 527
GLY A 523
LEU A 604
LEU A  92
 None
 1.05A 1nr6A-4cvcA:
undetectable		 1nr6A-4cvcA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxk ARYLSULFATASE

(Pseudomonas
aeruginosa) 		PF00884
(Sulfatase) 		5 LEU A 373
ALA A 376
PHE A 377
GLY A 322
ALA A 323
 None
 1.17A 1nr6A-4cxkA:
undetectable		 1nr6A-4cxkA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga6 PUTATIVE THYMIDINE
PHOSPHORYLASE

(Thermococcus
kodakarensis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 ALA A 145
ALA A 242
THR A 246
LEU A 260
LEU A 142
 None
 1.12A 1nr6A-4ga6A:
undetectable		 1nr6A-4ga6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hds ARSA

(Sporomusa ovata) 		PF02277
(DBI_PRT) 		5 LEU A 174
ALA A  65
GLY A 157
ALA A 247
LEU A 237
 None
 1.12A 1nr6A-4hdsA:
undetectable		 1nr6A-4hdsA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sus scrofa) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A  46
PHE A 281
GLY A  56
ALA A  55
LEU A  81
 None
 1.14A 1nr6A-4i9aA:
undetectable		 1nr6A-4i9aA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iis BETA-1,3-GLUCANASE
FORM 'RRII GLN 2'

(Hevea
brasiliensis) 		PF00332
(Glyco_hydro_17) 		5 LEU A 159
ALA A 225
PHE A 151
GLY A 231
LEU A 222
 None
 1.06A 1nr6A-4iisA:
undetectable		 1nr6A-4iisA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 230
GLY A 191
ALA A 190
THR A 187
LEU A 237
 None
 0.70A 1nr6A-4ip4A:
undetectable		 1nr6A-4ip4A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		5 LEU A 965
ALA A 970
GLY A 935
LEU A 960
LEU A 962
 None
None
NAG  A1148 (-4.1A)
None
None
 1.16A 1nr6A-4iugA:
undetectable		 1nr6A-4iugA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jip GTN REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		5 LEU A   4
GLY A  49
ALA A  48
LEU A 337
PHE A 327
 None
 1.14A 1nr6A-4jipA:
undetectable		 1nr6A-4jipA:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		6 LEU A 105
ALA A 113
PHE A 114
GLY A 301
ALA A 302
THR A 306
 3QZ  A 601 ( 4.2A)
HEM  A 600 ( 2.9A)
3QZ  A 601 ( 4.1A)
3QZ  A 601 ( 3.0A)
3QZ  A 601 (-2.9A)
HEM  A 600 ( 3.2A)
 1.07A 1nr6A-4nkyA:
44.8		 1nr6A-4nkyA:
32.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nl4 PRIMOSOME ASSEMBLY
PROTEIN PRIA

(Klebsiella
pneumoniae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU H 541
GLY H 582
LEU H 555
LEU H 576
PHE H 423
 None
 1.14A 1nr6A-4nl4H:
undetectable		 1nr6A-4nl4H:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ntd THIOREDOXIN
REDUCTASE

(Streptomyces
clavuligerus) 		PF07992
(Pyr_redox_2) 		5 ALA A 166
GLY A 161
ALA A 162
LEU A 185
LEU A 193
 None
 1.15A 1nr6A-4ntdA:
undetectable		 1nr6A-4ntdA:
23.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 LEU A 118
ALA A 126
GLY A 312
ALA A 313
THR A 317
 None
HEM  A 600 (-3.6A)
AER  A 601 ( 3.7A)
HEM  A 600 (-3.5A)
HEM  A 600 ( 3.3A)
 1.07A 1nr6A-4r1zA:
44.1		 1nr6A-4r1zA:
32.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2

(Danio rerio) 		PF00067
(p450) 		6 LEU A 112
ALA A 120
PHE A 121
GLY A 301
ALA A 302
THR A 306
 AER  A 602 ( 4.8A)
AER  A 602 (-3.7A)
None
AER  A 602 ( 3.8A)
HEM  A 601 (-3.4A)
HEM  A 601 ( 3.3A)
 1.31A 1nr6A-4r20A:
43.7		 1nr6A-4r20A:
35.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7b CHOLINE KINASE

(Streptococcus
pneumoniae) 		PF01633
(Choline_kinase) 		5 LEU A 192
PHE A 182
ALA A 110
LEU A 207
LEU A 210
 None
 1.08A 1nr6A-4r7bA:
undetectable		 1nr6A-4r7bA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhp UBIQUINONE
BIOSYNTHESIS PROTEIN
COQ9, MITOCHONDRIAL

(Homo sapiens) 		PF08511
(COQ9) 		5 LEU A 145
ALA A 135
GLY A 124
ALA A 125
LEU A  99
 None
 1.01A 1nr6A-4rhpA:
undetectable		 1nr6A-4rhpA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzh LIC12234

(Leptospira
interrogans) 		PF13855
(LRR_8) 		5 LEU A 203
PHE A 204
GLY A 154
LEU A 164
LEU A 185
 None
 0.91A 1nr6A-4tzhA:
undetectable		 1nr6A-4tzhA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		5 LEU A 282
GLY A 289
ALA A 288
LEU A 320
LEU A 324
 None
 1.10A 1nr6A-4wb7A:
undetectable		 1nr6A-4wb7A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9d C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 LEU A  62
ALA A  92
GLY A 118
LEU A  88
PHE A  10
 None
NAI  A 401 (-3.6A)
None
None
None
 1.12A 1nr6A-4y9dA:
undetectable		 1nr6A-4y9dA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yac C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 LEU A  63
ALA A  92
GLY A 118
LEU A  88
PHE A  10
 None
NAI  A 500 ( 4.1A)
None
None
None
 1.17A 1nr6A-4yacA:
undetectable		 1nr6A-4yacA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		5 ALA A 174
GLY A  13
THR A  97
LEU A 211
LEU A 215
 None
 1.10A 1nr6A-4yisA:
undetectable		 1nr6A-4yisA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 ALA A 237
GLY A 303
ALA A 293
LEU A 266
LEU A 235
 None
 1.14A 1nr6A-4zpqA:
undetectable		 1nr6A-4zpqA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zqb NADP-DEPENDENT
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF02826
(2-Hacid_dh_C) 		5 LEU A 217
ALA A 240
GLY A 247
LEU A 251
LEU A 237
 None
 1.07A 1nr6A-4zqbA:
undetectable		 1nr6A-4zqbA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ab4 SCP2-THIOLASE LIKE
PROTEIN

(Trypanosoma
brucei) 		no annotation 6 ALA A 277
PHE A 281
ALA A 310
LEU A 296
LEU A 389
PHE A 294
 None
 1.35A 1nr6A-5ab4A:
undetectable		 1nr6A-5ab4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aq1 GLUCOSE-6-PHOSPHATE
DEHYDROGENASE

(Trypanosoma
cruzi) 		PF00479
(G6PD_N)
PF02781
(G6PD_C) 		5 LEU A 236
PHE A 237
GLY A 201
ALA A 202
LEU A  74
 None
 1.06A 1nr6A-5aq1A:
undetectable		 1nr6A-5aq1A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5auo ATPASE INVOLVED IN
CHROMOSOME
PARTITIONING,
PARA/MIND FAMILY,
MRP HOMOLOG

(Thermococcus
kodakarensis) 		PF10609
(ParA) 		5 GLY B 239
ALA B 238
THR B  39
LEU B  35
LEU B 222
 None
None
None
ACP  B 301 (-3.9A)
ACP  B 301 ( 4.4A)
 1.10A 1nr6A-5auoB:
undetectable		 1nr6A-5auoB:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6m DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Shewanella
halifaxensis) 		PF01791
(DeoC) 		5 LEU A  14
ALA A 209
ALA A   7
LEU A 245
LEU A 241
 None
 1.05A 1nr6A-5c6mA:
undetectable		 1nr6A-5c6mA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epd GLYCEROL TRINITRATE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF00724
(Oxidored_FMN) 		5 LEU A   6
GLY A  52
ALA A  51
LEU A 326
PHE A 316
 None
 1.17A 1nr6A-5epdA:
undetectable		 1nr6A-5epdA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 LEU A 378
GLY A 372
LEU A 432
LEU A 412
PHE A 435
 None
 1.16A 1nr6A-5fdnA:
undetectable		 1nr6A-5fdnA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 LEU A 128
ALA A  88
GLY A  83
ALA A  84
PHE A 112
 None
None
NA  B1986 ( 3.9A)
None
None
 1.15A 1nr6A-5fq6A:
undetectable		 1nr6A-5fq6A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjw VOLTAGE-DEPENDENT
CALCIUM CHANNEL
SUBUNIT
ALPHA-2/DELTA-1

(Oryctolagus
cuniculus) 		PF00092
(VWA)
PF08399
(VWA_N)
PF08473
(VGCC_alpha2) 		5 ALA F 712
GLY F 742
LEU F 683
LEU F 651
PHE F 686
 None
 1.08A 1nr6A-5gjwF:
undetectable		 1nr6A-5gjwF:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnm VITAMIN D(3)
25-HYDROXYLASE

(Pseudonocardia
autotrophica) 		PF00067
(p450) 		5 ALA A 272
PHE A 276
GLY A 357
LEU A 262
PHE A 365
 None
 1.12A 1nr6A-5gnmA:
26.9		 1nr6A-5gnmA:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 LEU A 618
ALA A 357
GLY A 387
ALA A 386
LEU A 429
 None
 1.14A 1nr6A-5h53A:
undetectable		 1nr6A-5h53A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmq 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase)
PF01261
(AP_endonuc_2)
PF14696
(Glyoxalase_5) 		5 LEU A 299
PHE A 301
THR A 589
LEU A 318
LEU A 315
 None
 1.07A 1nr6A-5hmqA:
undetectable		 1nr6A-5hmqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jry NAD-DEPENDENT
ALDEHYDE
DEHYDROGENASE

(Burkholderia
multivorans) 		PF00171
(Aldedh) 		5 LEU A 105
ALA A 160
GLY A 185
ALA A 186
LEU A 193
 None
 1.13A 1nr6A-5jryA:
undetectable		 1nr6A-5jryA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		5 LEU A 272
PHE A 238
GLY A 231
LEU A 208
LEU A 324
 None
 0.95A 1nr6A-5nsqA:
undetectable		 1nr6A-5nsqA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 ALA A 414
PHE A 418
GLY A 254
ALA A 253
LEU A 245
 None
 0.99A 1nr6A-5oltA:
undetectable		 1nr6A-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3e TRANSCRIPTIONAL
REGULATOR

(Porphyromonas
gingivalis) 		no annotation 5 LEU A  55
GLY A  83
ALA A  10
LEU A  25
LEU A  29
 None
 0.95A 1nr6A-5v3eA:
undetectable		 1nr6A-5v3eA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 ALA A 529
PHE A 519
GLY A 515
LEU A 611
LEU A  71
 None
 1.05A 1nr6A-5xm3A:
undetectable		 1nr6A-5xm3A:
10.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 6 PHE A 114
GLY A 296
ALA A 297
THR A 301
LEU A 362
LEU A 366
 LSN  A 503 (-3.8A)
LSN  A 501 (-3.5A)
LSN  A 501 ( 3.3A)
HEM  A 504 (-4.0A)
LSN  A 503 ( 3.7A)
HEM  A 504 ( 4.4A)
 0.76A 1nr6A-5xxiA:
55.4		 1nr6A-5xxiA:
76.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 5 ALA A 176
GLY A 227
ALA A  19
LEU A 386
LEU A 173
 None
 1.09A 1nr6A-5yptA:
undetectable		 1nr6A-5yptA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
HELICASE, CAS3
FAMILY

(Thermobifida
fusca) 		no annotation 5 LEU G  46
ALA G 214
GLY G  81
ALA G  80
LEU G 210
 None
 1.15A 1nr6A-6c66G:
undetectable		 1nr6A-6c66G:
9.54