SIMILAR PATTERNS OF AMINO ACIDS FOR 1NP1_B_HSMB304

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dr9 T LYMPHOCYTE
ACTIVATION ANTIGEN

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		3 ASP A  76
LEU A  70
LEU A  72
 None
 0.63A 1np1B-1dr9A:
undetectable		 1np1B-1dr9A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		3 ASP B  31
LEU B  45
LEU B  43
 None
 0.55A 1np1B-1fftB:
0.0		 1np1B-1fftB:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hn0 CHONDROITIN ABC
LYASE I

(Proteus
vulgaris) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ASP A 914
LEU A 765
LEU A 759
 None
 0.71A 1np1B-1hn0A:
0.0		 1np1B-1hn0A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ji7 ETS-RELATED PROTEIN
TEL1

(Homo sapiens) 		PF02198
(SAM_PNT) 		3 ASP A  69
LEU A  64
LEU A  65
 None
 0.80A 1np1B-1ji7A:
undetectable		 1np1B-1ji7A:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlk RESPONSE REGULATOR
RCP1

(Synechocystis
sp. PCC 6803) 		PF00072
(Response_reg) 		3 ASP A  16
LEU A  69
LEU A  71
 MN  A 627 ( 2.3A)
None
None
 0.76A 1np1B-1jlkA:
0.0		 1np1B-1jlkA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k4n PROTEIN EC4020

(Escherichia
coli) 		PF06185
(YecM) 		3 ASP A 170
LEU A  28
LEU A  31
 None
 0.68A 1np1B-1k4nA:
0.0		 1np1B-1k4nA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		3 ASP A 179
LEU A 165
LEU A 169
 None
 0.77A 1np1B-1n4oA:
0.0		 1np1B-1n4oA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ny5 TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		3 ASP A   8
LEU A  52
LEU A  54
 None
 0.74A 1np1B-1ny5A:
0.0		 1np1B-1ny5A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4f RNA-DEPENDENT RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		3 ASP A 247
LEU A 240
LEU A 244
 None
 0.56A 1np1B-1s4fA:
undetectable		 1np1B-1s4fA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		3 ASP A  91
LEU A 123
LEU A 125
 None
 0.76A 1np1B-1to3A:
0.0		 1np1B-1to3A:
21.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u0x NITROPHORIN 4

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		3 ASP A  30
LEU A 123
LEU A 133
 None
HEM  A 185 (-4.4A)
NH3  A 186 ( 4.8A)
 0.41A 1np1B-1u0xA:
31.9		 1np1B-1u0xA:
90.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xiw IMMUNOGLOBULIN HEAVY
CHAIN VARIABLE
REGION

(Mus musculus) 		PF07686
(V-set) 		3 ASP D  90
LEU D  84
LEU D  86
 None
 0.65A 1np1B-1xiwD:
undetectable		 1np1B-1xiwD:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9f PUTATIVE MALIC
ENZYME
((S)-MALATE:NAD+
OXIDOREDUCTASE
(DECARBOXYLATING))

(Streptococcus
pyogenes) 		PF00390
(malic)
PF03949
(Malic_M) 		3 ASP A 359
LEU A 179
LEU A 181
 None
 0.72A 1np1B-2a9fA:
undetectable		 1np1B-2a9fA:
18.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2asn NITROPHORIN 2

(Rhodnius
prolixus) 		PF02087
(Nitrophorin) 		3 ASP X  29
LEU X 122
LEU X 132
 None
IMD  X 202 ( 4.2A)
IMD  X 202 (-3.9A)
 0.34A 1np1B-2asnX:
27.0		 1np1B-2asnX:
46.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byf PHOSPHOLIPASE C,
EPSILON 1

(Homo sapiens) 		PF00788
(RA) 		3 ASP A  13
LEU A 105
LEU A 103
 None
 0.72A 1np1B-2byfA:
undetectable		 1np1B-2byfA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c8s CYTOCHROME C-L

(Methylobacterium
extorquens) 		PF13442
(Cytochrome_CBB3) 		3 ASP A 119
LEU A  46
LEU A 122
 None
 0.77A 1np1B-2c8sA:
undetectable		 1np1B-2c8sA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqv AGR_C_4470P

(Agrobacterium
fabrum) 		PF06228
(ChuX_HutX) 		3 ASP A 165
LEU A 175
LEU A 171
 None
 0.80A 1np1B-2hqvA:
undetectable		 1np1B-2hqvA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l4c ENDOPLASMIC
RETICULUM RESIDENT
PROTEIN 27

(Homo sapiens) 		PF13848
(Thioredoxin_6) 		3 ASP A  98
LEU A  92
LEU A  94
 None
 0.59A 1np1B-2l4cA:
undetectable		 1np1B-2l4cA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lpm TWO-COMPONENT
RESPONSE REGULATOR

(Sinorhizobium
meliloti) 		PF00072
(Response_reg) 		3 ASP A  94
LEU A  75
LEU A  93
 None
 0.77A 1np1B-2lpmA:
undetectable		 1np1B-2lpmA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		3 ASP A 282
LEU A 275
LEU A 279
 None
 0.70A 1np1B-2p8uA:
undetectable		 1np1B-2p8uA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl1 TRANSCRIPTIONAL
REGULATORY PROTEIN
PHOP

(Escherichia
coli) 		PF00072
(Response_reg) 		3 ASP A   8
LEU A  52
LEU A  54
 MG  A 204 (-2.6A)
BEF  A 205 (-4.3A)
None
 0.75A 1np1B-2pl1A:
undetectable		 1np1B-2pl1A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Clostridium
acetobutylicum) 		PF06506
(PrpR_N) 		3 ASP A  51
LEU A   1
LEU A   3
 None
SO4  A 601 (-4.3A)
None
 0.58A 1np1B-2q5cA:
undetectable		 1np1B-2q5cA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT) 		3 ASP B  69
LEU B  64
LEU B  65
 None
 0.81A 1np1B-2qb0B:
undetectable		 1np1B-2qb0B:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxk GLUCOSAMINE
6-PHOSPHATE
ACETYLTRANSFERASE

(Aspergillus
fumigatus) 		PF00583
(Acetyltransf_1) 		3 ASP A  57
LEU A  97
LEU A  53
 None
 0.65A 1np1B-2vxkA:
undetectable		 1np1B-2vxkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1c ACYL-COENZYME

(Penicillium
chrysogenum) 		PF03417
(AAT) 		3 ASP A 337
LEU A 314
LEU A 330
 None
 0.63A 1np1B-2x1cA:
undetectable		 1np1B-2x1cA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1q GELSOLIN NANOBODY

(Lama glama) 		PF07686
(V-set) 		3 ASP A  90
LEU A  84
LEU A  86
 None
 0.78A 1np1B-2x1qA:
undetectable		 1np1B-2x1qA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg6 PUTRESCINE OXIDASE

(Rhodococcus
erythropolis) 		PF01593
(Amino_oxidase) 		3 ASP A 144
LEU A 188
LEU A 184
 None
 0.68A 1np1B-2yg6A:
undetectable		 1np1B-2yg6A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yua WILLIAMS-BEUREN
SYNDROME CHROMOSOME
REGION 18 PROTEIN

(Homo sapiens) 		PF00226
(DnaJ) 		3 ASP A  88
LEU A  83
LEU A  84
 None
 0.80A 1np1B-2yuaA:
undetectable		 1np1B-2yuaA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3au7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01336
(tRNA_anti-codon)
PF08489
(DUF1743) 		3 ASP A 318
LEU A 313
LEU A 314
 None
 0.75A 1np1B-3au7A:
undetectable		 1np1B-3au7A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7j TRANSCRIPTIONAL
REGULATOR, GNTR
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF00392
(GntR)
PF07729
(FCD) 		3 ASP A 120
LEU A 115
LEU A 116
 None
 0.69A 1np1B-3c7jA:
undetectable		 1np1B-3c7jA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		3 ASP A 394
LEU A 388
LEU A 391
 None
 0.61A 1np1B-3chxA:
undetectable		 1np1B-3chxA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb7 INSECTICIDAL
DELTA-ENDOTOXIN
CRY8EA1

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A 212
LEU A 205
LEU A 209
 None
 0.63A 1np1B-3eb7A:
undetectable		 1np1B-3eb7A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efb PROBABLE SOR-OPERON
REGULATOR

(Shigella
flexneri) 		PF04198
(Sugar-bind) 		3 ASP A  61
LEU A  56
LEU A  57
 None
 0.80A 1np1B-3efbA:
undetectable		 1np1B-3efbA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 ASP A 131
LEU A 138
LEU A 134
 None
 0.69A 1np1B-3ekgA:
undetectable		 1np1B-3ekgA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe5 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Bos taurus) 		PF06052
(3-HAO) 		3 ASP A 252
LEU A 246
LEU A 248
 None
 0.77A 1np1B-3fe5A:
undetectable		 1np1B-3fe5A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw0 PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01436
(NHL) 		3 ASP A 638
LEU A 694
LEU A 692
 CA  A 823 ( 4.6A)
None
None
 0.77A 1np1B-3fw0A:
undetectable		 1np1B-3fw0A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfh ETHANOLAMINE
UTILIZATION PROTEIN
EUTL

(Escherichia
coli) 		PF00936
(BMC) 		3 ASP A  46
LEU A 151
LEU A 125
 None
 0.79A 1np1B-3gfhA:
undetectable		 1np1B-3gfhA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5p NUCLEOPORIN NUP170

(Saccharomyces
cerevisiae) 		PF03177
(Nucleoporin_C) 		3 ASP A1110
LEU A1103
LEU A1107
 None
 0.52A 1np1B-3i5pA:
undetectable		 1np1B-3i5pA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic1 SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ASP A  22
LEU A  51
LEU A  49
 None
 0.69A 1np1B-3ic1A:
undetectable		 1np1B-3ic1A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luf TWO-COMPONENT SYSTEM
RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN

(Aeromonas
salmonicida) 		PF00072
(Response_reg) 		3 ASP A  10
LEU A  54
LEU A  56
 MG  A 301 (-2.6A)
None
None
 0.73A 1np1B-3lufA:
undetectable		 1np1B-3lufA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m33 UNCHARACTERIZED
PROTEIN

(Deinococcus
radiodurans) 		no annotation 3 ASP A 162
LEU A 211
LEU A 209
 None
 0.79A 1np1B-3m33A:
undetectable		 1np1B-3m33A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p04 UNCHARACTERIZED BCR

(Corynebacterium
glutamicum) 		PF04472
(SepF) 		3 ASP A  79
LEU A  99
LEU A  74
 None
 0.69A 1np1B-3p04A:
undetectable		 1np1B-3p04A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf7 BENZOYL-COA
OXYGENASE COMPONENT
B

(Azoarcus
evansii) 		no annotation 3 ASP A 363
LEU A 356
LEU A 360
 None
 0.57A 1np1B-3pf7A:
undetectable		 1np1B-3pf7A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rha PUTRESCINE OXIDASE

(Paenarthrobacter
aurescens) 		PF01593
(Amino_oxidase) 		3 ASP A 146
LEU A 190
LEU A 186
 None
 0.63A 1np1B-3rhaA:
undetectable		 1np1B-3rhaA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ria MOUSE MONOCLONAL FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP F  90
LEU F  84
LEU F  86
 None
 0.50A 1np1B-3riaF:
undetectable		 1np1B-3riaF:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqa PUTATIVE
UNCHARACTERIZED
PROTEIN

(Xanthomonas
campestris) 		PF16823
(PilZ_2) 		3 ASP A  75
LEU A  82
LEU A  78
 None
 0.73A 1np1B-3rqaA:
undetectable		 1np1B-3rqaA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rv0 K. POLYSPORUS DCR1

(Vanderwaltozyma
polyspora) 		PF00636
(Ribonuclease_3) 		3 ASP A  62
LEU A  52
LEU A  54
 None
 0.56A 1np1B-3rv0A:
undetectable		 1np1B-3rv0A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5t DUF3298 FAMILY
PROTEIN

(Bacteroides
fragilis) 		PF11738
(DUF3298)
PF13739
(DUF4163) 		3 ASP A 209
LEU A 202
LEU A 206
 None
 0.50A 1np1B-3s5tA:
undetectable		 1np1B-3s5tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3srz TOXIN A

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 ASP A  77
LEU A  12
LEU A  74
 None
 0.75A 1np1B-3srzA:
undetectable		 1np1B-3srzA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tp2 PRE-MRNA-SPLICING
FACTOR CWC2

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16131
(Torus) 		3 ASP A 209
LEU A 204
LEU A 205
 None
 0.72A 1np1B-3tp2A:
undetectable		 1np1B-3tp2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vn9 DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 239
LEU A 169
LEU A 166
 None
 0.69A 1np1B-3vn9A:
undetectable		 1np1B-3vn9A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9s OMPR FAMILY RESPONSE
REGULATOR IN
TWO-COMPONENT
REGULATORY SYSTEM
WITH BASS

(Klebsiella
pneumoniae) 		PF00072
(Response_reg) 		3 ASP A   8
LEU A  52
LEU A  54
 MG  A 202 (-2.6A)
BEF  A 201 (-4.5A)
None
 0.75A 1np1B-3w9sA:
undetectable		 1np1B-3w9sA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 246
LEU A 181
LEU A 178
 None
 0.79A 1np1B-3wigA:
undetectable		 1np1B-3wigA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ASP A  39
LEU A  28
LEU A  25
 None
 0.78A 1np1B-3wjpA:
undetectable		 1np1B-3wjpA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsu TLL2057 PROTEIN

(Thermosynechococcus
elongatus) 		no annotation 3 ASP A 114
LEU A 107
LEU A 111
 None
 0.53A 1np1B-3zsuA:
undetectable		 1np1B-3zsuA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1f REPLICATIVE DNA
HELICASE

(Helicobacter
pylori) 		PF03796
(DnaB_C) 		3 ASP A 374
LEU A 315
LEU A 317
 None
 0.69A 1np1B-4a1fA:
undetectable		 1np1B-4a1fA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4csu GTPASE OBGE/CGTA

(Escherichia
coli) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		3 ASP 9  98
LEU 9  10
LEU 9 152
 None
 0.75A 1np1B-4csu9:
undetectable		 1np1B-4csu9:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f33 MORAB-009 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP B  90
LEU B  84
LEU B  86
 None
 0.64A 1np1B-4f33B:
undetectable		 1np1B-4f33B:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl0 LMO0810 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		3 ASP A 193
LEU A 187
LEU A 184
 None
 0.80A 1np1B-4gl0A:
undetectable		 1np1B-4gl0A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h2k SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Haemophilus
influenzae) 		PF01546
(Peptidase_M20) 		3 ASP A  22
LEU A  51
LEU A  49
 None
 0.76A 1np1B-4h2kA:
undetectable		 1np1B-4h2kA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hea NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 12

(Thermus
thermophilus) 		PF00361
(Proton_antipo_M)
PF00662
(Proton_antipo_N) 		3 ASP L 386
LEU L 393
LEU L 389
 None
 0.79A 1np1B-4heaL:
undetectable		 1np1B-4heaL:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE

(Homo sapiens) 		PF04909
(Amidohydro_2) 		3 ASP A 279
LEU A 272
LEU A 276
 None
 0.57A 1np1B-4igmA:
undetectable		 1np1B-4igmA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0w U3 SMALL NUCLEOLAR
RNA-INTERACTING
PROTEIN 2

(Homo sapiens) 		PF00400
(WD40) 		3 ASP A 290
LEU A 386
LEU A 332
 None
 0.72A 1np1B-4j0wA:
undetectable		 1np1B-4j0wA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhl INTERLEUKIN-11

(Homo sapiens) 		PF07400
(IL11) 		3 ASP A  52
LEU A  45
LEU A  49
 SO4  A 201 (-4.3A)
None
None
 0.52A 1np1B-4mhlA:
undetectable		 1np1B-4mhlA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 3 ASP B 304
LEU B 348
LEU B 346
 None
 0.74A 1np1B-4o9dB:
undetectable		 1np1B-4o9dB:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pl9 ETHYLENE RECEPTOR 1

(Arabidopsis
thaliana) 		PF02518
(HATPase_c) 		3 ASP A 456
LEU A 410
LEU A 412
 None
 0.77A 1np1B-4pl9A:
undetectable		 1np1B-4pl9A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6g PYRROLYSINE--TRNA
LIGASE

(Methanosarcina
mazei) 		PF01409
(tRNA-synt_2d) 		3 ASP A 206
LEU A 201
LEU A 202
 None
 0.74A 1np1B-4q6gA:
undetectable		 1np1B-4q6gA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r9i SERPIN-18

(Bombyx mori) 		PF00079
(Serpin) 		3 ASP A 306
LEU A 185
LEU A 343
 None
 0.79A 1np1B-4r9iA:
undetectable		 1np1B-4r9iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwh T-LYMPHOCYTE
ACTIVATION ANTIGEN
CD80

(Mus musculus) 		PF07686
(V-set) 		3 ASP A  74
LEU A  68
LEU A  70
 None
 0.58A 1np1B-4rwhA:
undetectable		 1np1B-4rwhA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s05 DNA-BINDING
TRANSCRIPTIONAL
REGULATOR BASR

(Klebsiella
pneumoniae) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		3 ASP A   8
LEU A  52
LEU A  54
 MG  A 302 (-2.7A)
None
None
 0.67A 1np1B-4s05A:
undetectable		 1np1B-4s05A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		3 ASP A  70
LEU A  59
LEU A  60
 None
 0.73A 1np1B-4uaqA:
undetectable		 1np1B-4uaqA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 1
ORIGIN RECOGNITION
COMPLEX SUBUNIT 4

(Drosophila
melanogaster) 		PF00004
(AAA)
PF09079
(Cdc6_C)
PF13191
(AAA_16)
PF14629
(ORC4_C) 		3 ASP A 899
LEU D 429
LEU A 900
 None
 0.49A 1np1B-4xgcA:
undetectable		 1np1B-4xgcA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5btr NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-1

(Homo sapiens) 		PF02146
(SIR2) 		3 ASP A 334
LEU A 340
LEU A 339
 None
 0.80A 1np1B-5btrA:
undetectable		 1np1B-5btrA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		3 ASP A1955
LEU A1995
LEU A1994
 None
 0.71A 1np1B-5ejsA:
undetectable		 1np1B-5ejsA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 ASP B 427
LEU B 420
LEU B 424
 None
 0.57A 1np1B-5ip9B:
undetectable		 1np1B-5ip9B:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA

(Homo sapiens;
Klebsiella
pneumoniae) 		PF01475
(FUR)
PF02198
(SAM_PNT) 		3 ASP A  65
LEU A  60
LEU A  61
 None
 0.74A 1np1B-5l0pA:
undetectable		 1np1B-5l0pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0p TRANSCRIPTION FACTOR
ETV6, TRANSCRIPTION
FACTOR ETV6,
TRANSCRIPTION FACTOR
ETV6, FERRIC UPTAKE
REGULATION PROTEIN
CHIMERA

(Homo sapiens;
Klebsiella
pneumoniae) 		PF01475
(FUR)
PF02198
(SAM_PNT) 		3 ASP A 236
LEU A 231
LEU A 232
 None
 0.74A 1np1B-5l0pA:
undetectable		 1np1B-5l0pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7s SECRETED RXLR
EFFECTOR PEPTIDE
PROTEIN

(Phytophthora
infestans) 		no annotation 3 ASP A 254
LEU A 278
LEU A 291
 None
 0.75A 1np1B-5l7sA:
undetectable		 1np1B-5l7sA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13481
(AAA_25)
PF13541
(ChlI) 		3 ASP A 367
LEU A 395
LEU A 393
 None
 0.75A 1np1B-5lkmA:
undetectable		 1np1B-5lkmA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkq DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13541
(ChlI) 		3 ASP A 367
LEU A 395
LEU A 393
 None
 0.80A 1np1B-5lkqA:
undetectable		 1np1B-5lkqA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mbv HOST-NUCLEASE
INHIBITOR PROTEIN
GAM

(Escherichia
virus Lambda) 		PF06064
(Gam) 		3 ASP A  90
LEU A  83
LEU A  87
 None
 0.76A 1np1B-5mbvA:
undetectable		 1np1B-5mbvA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhr 9BG5 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 ASP I  90
LEU I  84
LEU I  86
 None
 0.59A 1np1B-5mhrI:
undetectable		 1np1B-5mhrI:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mv9 UNCONVENTIONAL
MYOSIN-VIIA

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		3 ASP A1811
LEU A1851
LEU A1850
 None
 0.72A 1np1B-5mv9A:
undetectable		 1np1B-5mv9A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngj TAIL TUBE PROTEIN

(Escherichia
virus T5) 		no annotation 3 ASP A  91
LEU A  98
LEU A  94
 None
 0.65A 1np1B-5ngjA:
undetectable		 1np1B-5ngjA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S4

(Trypanosoma
cruzi) 		no annotation 3 ASP L 140
LEU L 120
LEU L 121
 None
 0.79A 1np1B-5optL:
undetectable		 1np1B-5optL:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0D15741P
KLLA0E05809P

(Kluyveromyces
lactis) 		PF03980
(Nnf1)
PF08202
(MIS13) 		3 ASP D 392
LEU B 118
LEU B 121
 None
 0.70A 1np1B-5t58D:
undetectable		 1np1B-5t58D:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		3 ASP A  73
LEU A  67
LEU A  69
 None
 0.68A 1np1B-5tvgA:
undetectable		 1np1B-5tvgA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ugz PUTATIVE
THIOESTERASE

(Escherichia
coli) 		PF00975
(Thioesterase) 		3 ASP A 158
LEU A   9
LEU A  79
 None
 0.65A 1np1B-5ugzA:
undetectable		 1np1B-5ugzA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vip MDCE

(Pseudomonas
aeruginosa) 		PF06833
(MdcE) 		3 ASP A  26
LEU A  45
LEU A  30
 None
 0.70A 1np1B-5vipA:
undetectable		 1np1B-5vipA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Coxiella
burnetii) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		3 ASP A  91
LEU A 228
LEU A 231
 None
 0.78A 1np1B-5wolA:
undetectable		 1np1B-5wolA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbf UNCONVENTIONAL
MYOSIN-VIIB

(Homo sapiens) 		PF00373
(FERM_M)
PF00784
(MyTH4) 		3 ASP A1708
LEU A1748
LEU A1747
 None
 0.70A 1np1B-5xbfA:
undetectable		 1np1B-5xbfA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfo PHD FINGER PROTEIN 1

(Homo sapiens) 		PF00628
(PHD) 		3 ASP A 253
LEU A 247
LEU A 249
 None
 0.69A 1np1B-5xfoA:
undetectable		 1np1B-5xfoA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfr METAL-RESPONSE
ELEMENT-BINDING
TRANSCRIPTION FACTOR
2

(Homo sapiens) 		PF00628
(PHD) 		3 ASP A 268
LEU A 262
LEU A 264
 None
 0.72A 1np1B-5xfrA:
undetectable		 1np1B-5xfrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xvn CRISPR-ASSOCIATED
ENDONUCLEASE CAS1

(Enterococcus
faecalis) 		PF01867
(Cas_Cas1) 		3 ASP A 216
LEU A 200
LEU A 213
 None
 0.72A 1np1B-5xvnA:
undetectable		 1np1B-5xvnA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze4 DIHYDROXY-ACID
DEHYDRATASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 3 ASP A 309
LEU A 303
LEU A 305
 None
 0.48A 1np1B-5ze4A:
undetectable		 1np1B-5ze4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6az6 GNTR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		no annotation 3 ASP A 127
LEU A 120
LEU A 124
 None
 0.49A 1np1B-6az6A:
undetectable		 1np1B-6az6A:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6brs PUTATIVE ZINC
PROTEASE

(Pectobacterium
atrosepticum) 		no annotation 3 ASP A 452
LEU A 261
LEU A 262
 None
 0.78A 1np1B-6brsA:
undetectable		 1np1B-6brsA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 3 ASP A 363
LEU A 353
LEU A 358
 None
 0.79A 1np1B-6c9mA:
undetectable		 1np1B-6c9mA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cxh PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylomicrobium
alcaliphilum) 		no annotation 3 ASP A 382
LEU A 376
LEU A 379
 None
 0.35A 1np1B-6cxhA:
undetectable		 1np1B-6cxhA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ejb XYLOSYLTRANSFERASE 1

(Homo sapiens) 		no annotation 3 ASP A 764
LEU A 759
LEU A 760
 None
 0.80A 1np1B-6ejbA:
undetectable		 1np1B-6ejbA:
20.98