SIMILAR PATTERNS OF AMINO ACIDS FOR 1NP1_A_HSMA303_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE


(Escherichia
coli)
PF01750
(HycI)
4 GLU A  81
LEU A 116
LEU A  77
LEU A 114
None
0.85A 1np1A-1cfzA:
0.0
1np1A-1cfzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0x D-LACTATE
DEHYDROGENASE


(Escherichia
coli)
PF01565
(FAD_binding_4)
PF09330
(Lact-deh-memb)
4 GLU A 512
LEU A 518
LEU A 515
LEU A 517
None
0.93A 1np1A-1f0xA:
0.0
1np1A-1f0xA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffw CHEMOTAXIS PROTEIN
CHEA


(Escherichia
coli)
PF09078
(CheY-binding)
4 GLU B 177
LEU B 175
LEU B 174
LEU B 179
None
1.15A 1np1A-1ffwB:
0.0
1np1A-1ffwB:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krt LYSYL-TRNA
SYNTHETASE (PRODUCT
OF LYSS GENE)


(Escherichia
coli)
PF01336
(tRNA_anti-codon)
4 ASP A 120
LEU A 145
LEU A 122
LEU A 146
None
1.08A 1np1A-1krtA:
0.0
1np1A-1krtA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m3w H10H24

(-)
no annotation 4 GLU A  26
LEU A  20
LEU A  23
LEU A  21
None
1.18A 1np1A-1m3wA:
undetectable
1np1A-1m3wA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 GLU A 316
LEU A 310
LEU A 313
LEU A 311
None
1.15A 1np1A-1q1nA:
undetectable
1np1A-1q1nA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s28 ORF1

(Pseudomonas
savastanoi)
PF05932
(CesT)
4 GLU A 124
LEU A 118
LEU A 121
LEU A 119
None
0.99A 1np1A-1s28A:
undetectable
1np1A-1s28A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skv HYPOTHETICAL 7.5 KDA
PROTEIN


(Sulfolobus
spindle-shaped
virus 1)
no annotation 4 GLU A  27
LEU A  21
LEU A  24
LEU A  22
None
1.16A 1np1A-1skvA:
undetectable
1np1A-1skvA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1u0x NITROPHORIN 4

(Rhodnius
prolixus)
PF02087
(Nitrophorin)
4 ASP A  30
GLU A  32
LEU A 123
LEU A 133
None
None
HEM  A 185 (-4.4A)
NH3  A 186 ( 4.8A)
0.79A 1np1A-1u0xA:
32.1
1np1A-1u0xA:
90.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wn1 DIPEPTIDASE

(Pyrococcus
horikoshii)
PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
4 GLU A  99
LEU A  97
LEU A 121
LEU A  19
None
1.14A 1np1A-1wn1A:
undetectable
1np1A-1wn1A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xxl YCGJ PROTEIN

(Bacillus
subtilis)
PF08241
(Methyltransf_11)
4 ASP A 115
GLU A 142
LEU A 167
LEU A 218
None
None
SO4  A 404 (-4.6A)
None
1.10A 1np1A-1xxlA:
undetectable
1np1A-1xxlA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ye8 HYPOTHETICAL UPF0334
KINASE-LIKE PROTEIN
AQ_1292


(Aquifex
aeolicus)
PF03266
(NTPase_1)
4 GLU A 170
LEU A 176
LEU A 173
LEU A 175
None
1.13A 1np1A-1ye8A:
undetectable
1np1A-1ye8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yke RNA POLYMERASE II
MEDIATOR COMPLEX
PROTEIN MED7


(Saccharomyces
cerevisiae)
PF05983
(Med7)
4 GLU A 180
LEU A 178
LEU A 177
LEU A 182
None
1.14A 1np1A-1ykeA:
undetectable
1np1A-1ykeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yya TRIOSEPHOSPHATE
ISOMERASE


(Thermus
thermophilus)
PF00121
(TIM)
4 GLU A 240
LEU A 246
LEU A 243
LEU A 245
None
0.92A 1np1A-1yyaA:
undetectable
1np1A-1yyaA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz6 PROBABLE TRANSLATION
INITIATION FACTOR 2
ALPHA SUBUNIT


(Pyrococcus
abyssi)
PF00575
(S1)
PF07541
(EIF_2_alpha)
4 GLU A 112
LEU A 106
LEU A 109
LEU A 107
None
1.00A 1np1A-1yz6A:
undetectable
1np1A-1yz6A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9c SULFITE OXIDASE

(Gallus gallus)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
4 GLU A 169
LEU A 153
LEU A 165
LEU A 167
None
0.98A 1np1A-2a9cA:
undetectable
1np1A-2a9cA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btd PTS-DEPENDENT
DIHYDROXYACETONE
KINASE


(Escherichia
coli)
PF02734
(Dak2)
4 GLU A 105
LEU A   3
LEU A 101
LEU A 103
None
0.88A 1np1A-2btdA:
undetectable
1np1A-2btdA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dh3 4F2 CELL-SURFACE
ANTIGEN HEAVY CHAIN


(Homo sapiens)
PF00128
(Alpha-amylase)
4 GLU A 504
LEU A 522
LEU A 496
LEU A 523
None
1.08A 1np1A-2dh3A:
undetectable
1np1A-2dh3A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE


(Aquifex
aeolicus)
PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N)
4 ASP A 224
GLU A 222
LEU A 228
LEU A 226
None
1.06A 1np1A-2dq3A:
undetectable
1np1A-2dq3A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 GLU A 131
LEU A 125
LEU A 128
LEU A 126
None
1.15A 1np1A-2e5vA:
undetectable
1np1A-2e5vA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Aquifex
aeolicus)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 GLU A 187
LEU A 300
LEU A 185
LEU A 189
None
1.05A 1np1A-2ebdA:
undetectable
1np1A-2ebdA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1r MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B (MOBB)


(Archaeoglobus
fulgidus)
PF03205
(MobB)
4 GLU A 154
LEU A 160
LEU A 157
LEU A 159
None
0.97A 1np1A-2f1rA:
undetectable
1np1A-2f1rA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fup HYPOTHETICAL PROTEIN
PA3352


(Pseudomonas
aeruginosa)
PF05130
(FlgN)
4 GLU A  13
LEU A   7
LEU A  10
LEU A   8
None
1.10A 1np1A-2fupA:
undetectable
1np1A-2fupA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4l URIDYLATE KINASE

(Sulfolobus
solfataricus)
PF00696
(AA_kinase)
4 GLU A  61
LEU A  67
LEU A  64
LEU A  66
None
1.16A 1np1A-2j4lA:
undetectable
1np1A-2j4lA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgn ATP-DEPENDENT RNA
HELICASE DDX3X


(Homo sapiens)
PF00271
(Helicase_C)
4 GLU A 561
LEU A 555
LEU A 558
LEU A 556
None
0.95A 1np1A-2jgnA:
undetectable
1np1A-2jgnA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpc PYRIN

(Homo sapiens)
PF02758
(PYRIN)
4 GLU A  84
LEU A  82
LEU A  81
LEU A  86
None
1.16A 1np1A-2mpcA:
undetectable
1np1A-2mpcA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o16 ACETOIN UTILIZATION
PROTEIN ACUB,
PUTATIVE


(Vibrio cholerae)
PF00571
(CBS)
4 GLU A 158
LEU A 152
LEU A 155
LEU A 153
None
1.01A 1np1A-2o16A:
undetectable
1np1A-2o16A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q97 TOXOFILIN

(Toxoplasma
gondii)
no annotation 4 GLU T 114
LEU T 112
LEU T 111
LEU T 116
None
1.16A 1np1A-2q97T:
undetectable
1np1A-2q97T:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyt 2-DEHYDROPANTOATE
2-REDUCTASE


(Porphyromonas
gingivalis)
PF02558
(ApbA)
PF08546
(ApbA_C)
4 GLU A 233
LEU A 227
LEU A 230
LEU A 228
None
1.16A 1np1A-2qytA:
undetectable
1np1A-2qytA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2


(Homo sapiens)
PF00709
(Adenylsucc_synt)
4 ASP A 212
GLU A 214
LEU A 220
LEU A 217
None
1.07A 1np1A-2v40A:
undetectable
1np1A-2v40A:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdu GLUTATHIONE
TRANSFERASE SIGMA
CLASS


(Fasciola
hepatica)
PF14497
(GST_C_3)
4 GLU A 141
LEU A 135
LEU A 138
LEU A 136
None
1.17A 1np1A-2wduA:
undetectable
1np1A-2wduA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wte CSA3

(Sulfolobus
solfataricus)
no annotation 4 GLU A  21
LEU A  15
LEU A  18
LEU A  16
None
1.01A 1np1A-2wteA:
undetectable
1np1A-2wteA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE


(Mycolicibacterium
smegmatis)
PF09334
(tRNA-synt_1g)
4 GLU A 181
LEU A 175
LEU A 178
LEU A 176
None
1.11A 1np1A-2x1mA:
undetectable
1np1A-2x1mA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9y ISWI ONE COMPLEX
PROTEIN 3


(Saccharomyces
cerevisiae)
PF15612
(WHIM1)
4 GLU B 268
LEU B 261
LEU B 264
LEU B 262
None
1.10A 1np1A-2y9yB:
undetectable
1np1A-2y9yB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywm GLUTAREDOXIN-LIKE
PROTEIN


(Aquifex
aeolicus)
PF13192
(Thioredoxin_3)
4 GLU A 125
LEU A 131
LEU A 128
LEU A 130
None
1.01A 1np1A-2ywmA:
undetectable
1np1A-2ywmA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adr PUTATIVE
UNCHARACTERIZED
PROTEIN ST1585


(Sulfurisphaera
tokodaii)
PF00753
(Lactamase_B)
4 ASP A  92
GLU A  91
LEU A  97
LEU A  94
EDO  A 267 (-3.6A)
None
None
EDO  A 265 ( 4.5A)
1.18A 1np1A-3adrA:
undetectable
1np1A-3adrA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
4 GLU A  96
LEU A  90
LEU A  93
LEU A  91
None
0.95A 1np1A-3caiA:
undetectable
1np1A-3caiA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis)
PF05163
(DinB)
4 GLU A 126
LEU A 120
LEU A 123
LEU A 121
None
0.89A 1np1A-3dkaA:
undetectable
1np1A-3dkaA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2k HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR


(Homo sapiens)
PF01359
(Transposase_1)
4 GLU A 150
LEU A 128
LEU A 152
LEU A 127
None
1.05A 1np1A-3f2kA:
undetectable
1np1A-3f2kA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g68 PUTATIVE
PHOSPHOSUGAR
ISOMERASE


(Clostridioides
difficile)
PF01380
(SIS)
4 GLU A 224
LEU A 230
LEU A 227
LEU A 229
None
1.11A 1np1A-3g68A:
undetectable
1np1A-3g68A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae)
PF00891
(Methyltransf_2)
4 GLU A 235
LEU A 212
LEU A 237
LEU A 211
None
0.90A 1np1A-3gxoA:
undetectable
1np1A-3gxoA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmj FATTY ACID SYNTHASE
SUBUNIT ALPHA


(Saccharomyces
cerevisiae)
PF00109
(ketoacyl-synt)
PF01648
(ACPS)
PF02801
(Ketoacyl-synt_C)
4 GLU A 419
LEU A 413
LEU A 416
LEU A 414
None
1.06A 1np1A-3hmjA:
undetectable
1np1A-3hmjA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3isu RAS
GTPASE-ACTIVATING-LI
KE PROTEIN IQGAP3


(Homo sapiens)
no annotation 4 GLU A1602
LEU A1596
LEU A1599
LEU A1597
None
1.15A 1np1A-3isuA:
undetectable
1np1A-3isuA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izq ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN


(Saccharomyces
cerevisiae)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF08938
(HBS1_N)
4 ASP 1  66
GLU 1  68
LEU 1  74
LEU 1  71
None
1.13A 1np1A-3izq1:
undetectable
1np1A-3izq1:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lhx KETODEOXYGLUCONOKINA
SE


(Shigella
flexneri)
PF00294
(PfkB)
4 GLU A 228
LEU A 222
LEU A 225
LEU A 223
None
0.98A 1np1A-3lhxA:
undetectable
1np1A-3lhxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 GLU A 149
LEU A 190
LEU A 146
LEU A 191
None
None
None
ANP  A 522 (-4.7A)
0.97A 1np1A-3lijA:
undetectable
1np1A-3lijA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mg6 PROTEASOME COMPONENT
C11


(Saccharomyces
cerevisiae)
PF00227
(Proteasome)
4 GLU J 149
LEU J 155
LEU J 152
LEU J 154
None
0.98A 1np1A-3mg6J:
undetectable
1np1A-3mg6J:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
EPSILON


(Saccharomyces
cerevisiae)
PF04733
(Coatomer_E)
4 GLU B 130
LEU B 124
LEU B 127
LEU B 125
None
0.93A 1np1A-3mv3B:
undetectable
1np1A-3mv3B:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdi NITROGENASE MOFE
COFACTOR
BIOSYNTHESIS PROTEIN
NIFE


(Azotobacter
vinelandii)
PF00148
(Oxidored_nitro)
4 ASP A 390
GLU A 391
LEU A 385
LEU A 386
None
1.15A 1np1A-3pdiA:
undetectable
1np1A-3pdiA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfs BROMODOMAIN AND PHD
FINGER-CONTAINING
PROTEIN 3


(Homo sapiens)
PF00855
(PWWP)
4 ASP A1163
GLU A1159
LEU A1154
LEU A1156
None
1.09A 1np1A-3pfsA:
undetectable
1np1A-3pfsA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r18 SULFITE OXIDASE

(Gallus gallus)
PF00174
(Oxidored_molyb)
PF03404
(Mo-co_dimer)
4 GLU A 169
LEU A 153
LEU A 165
LEU A 167
None
0.87A 1np1A-3r18A:
undetectable
1np1A-3r18A:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rgc POSSIBLE PERIPLASMIC
PROTEIN


(Campylobacter
jejuni)
PF09312
(SurA_N)
4 GLU A 240
LEU A 196
LEU A 199
LEU A 197
None
1.04A 1np1A-3rgcA:
undetectable
1np1A-3rgcA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
4 GLU A 139
LEU A 180
LEU A 136
LEU A 181
None
1.17A 1np1A-3sxfA:
undetectable
1np1A-3sxfA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqf HPR(SER) KINASE

(Coxiella
burnetii)
PF07475
(Hpr_kinase_C)
4 GLU A 157
LEU A 155
LEU A 154
LEU A 159
None
1.17A 1np1A-3tqfA:
undetectable
1np1A-3tqfA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4f MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLU A  68
LEU A  62
LEU A  65
LEU A  63
None
1.18A 1np1A-3u4fA:
undetectable
1np1A-3u4fA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2)
PF00144
(Beta-lactamase)
4 GLU A 102
LEU A  96
LEU A  99
LEU A  97
None
1.14A 1np1A-3wwxA:
undetectable
1np1A-3wwxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x1l CRISPR SYSTEM CMR
SUBUNIT CMR2


(Pyrococcus
furiosus)
PF12469
(DUF3692)
4 GLU A 332
LEU A 326
LEU A 329
LEU A 327
None
1.15A 1np1A-3x1lA:
undetectable
1np1A-3x1lA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0h ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE


(Arabidopsis
thaliana)
PF00202
(Aminotran_3)
PF13500
(AAA_26)
4 GLU A 129
LEU A  52
LEU A 131
LEU A  51
None
1.12A 1np1A-4a0hA:
undetectable
1np1A-4a0hA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgs POLYMERASE SUBUNIT
PA


(Dhori
thogotovirus)
no annotation 4 GLU A 157
LEU A 161
LEU A 156
LEU A 160
None
0.84A 1np1A-4cgsA:
undetectable
1np1A-4cgsA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl3 TYROSINE-PROTEIN
KINASE SYK


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
4 GLU A 452
LEU A 502
LEU A 453
LEU A 501
None
None
None
ANP  A 701 (-4.5A)
1.12A 1np1A-4fl3A:
undetectable
1np1A-4fl3A:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gax AMORPHA-4,11-DIENE
SYNTHASE


(Artemisia annua)
PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C)
4 GLU A  69
LEU A  63
LEU A  66
LEU A  64
None
1.05A 1np1A-4gaxA:
undetectable
1np1A-4gaxA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htt SEC-INDEPENDENT
PROTEIN TRANSLOCASE
PROTEIN TATC,
LYSOZYME


(Aquifex
aeolicus;
Escherichia
virus T4)
PF00902
(TatC)
4 GLU A 221
LEU A 216
LEU A 217
LEU A 219
None
1.01A 1np1A-4httA:
undetectable
1np1A-4httA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i2w PROTEIN UNC-45

(Caenorhabditis
elegans)
PF11701
(UNC45-central)
4 GLU A 173
LEU A 167
LEU A 170
LEU A 168
None
1.07A 1np1A-4i2wA:
undetectable
1np1A-4i2wA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jmk DUAL SPECIFICITY
PROTEIN PHOSPHATASE
8


(Homo sapiens)
PF00782
(DSPc)
4 GLU A 297
LEU A 303
LEU A 300
LEU A 302
None
1.01A 1np1A-4jmkA:
undetectable
1np1A-4jmkA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6n AMINODEOXYCHORISMATE
LYASE


(Saccharomyces
cerevisiae)
PF01063
(Aminotran_4)
4 GLU A 153
LEU A 147
LEU A 150
LEU A 148
None
1.18A 1np1A-4k6nA:
undetectable
1np1A-4k6nA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0k ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Rhodothermus
marinus)
PF00156
(Pribosyltran)
4 GLU A  44
LEU A  38
LEU A  41
LEU A  39
None
1.08A 1np1A-4m0kA:
undetectable
1np1A-4m0kA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Polaromonas sp.
JS666)
PF03480
(DctP)
4 GLU A 263
LEU A 257
LEU A 260
LEU A 258
None
1.03A 1np1A-4mniA:
undetectable
1np1A-4mniA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnd TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 18


(Homo sapiens)
PF00102
(Y_phosphatase)
4 ASP A 114
LEU A  77
LEU A  78
LEU A  75
None
0.93A 1np1A-4nndA:
undetectable
1np1A-4nndA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oby ARGININE--TRNA
LIGASE


(Escherichia
coli)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
4 GLU A 396
LEU A 394
LEU A 393
LEU A 398
None
1.11A 1np1A-4obyA:
undetectable
1np1A-4obyA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN


(Aequorea
victoria;
Homo sapiens)
PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N)
4 GLU A 775
LEU A 769
LEU A 772
LEU A 770
None
1.17A 1np1A-4p7hA:
undetectable
1np1A-4p7hA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2q TIGHT JUNCTION
PROTEIN ZO-1


(Homo sapiens)
PF00595
(PDZ)
4 GLU A 481
LEU A 487
LEU A 484
LEU A 486
None
0.99A 1np1A-4q2qA:
undetectable
1np1A-4q2qA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4reu FERRITIN

(Escherichia
coli)
PF00210
(Ferritin)
4 ASP A 155
GLU A  37
LEU A  43
LEU A 158
None
0.96A 1np1A-4reuA:
undetectable
1np1A-4reuA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um2 TELOMERASE-BINDING
PROTEIN EST1A


(Homo sapiens)
PF10373
(EST1_DNA_bind)
PF10374
(EST1)
4 GLU A 680
LEU A 674
LEU A 677
LEU A 675
None
1.00A 1np1A-4um2A:
undetectable
1np1A-4um2A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uw9 BETA-PHOSPHOGLUCOMUT
ASE


(Pyrococcus sp.
ST04)
PF13419
(HAD_2)
4 GLU A  69
LEU A  75
LEU A  72
LEU A  74
None
1.05A 1np1A-4uw9A:
undetectable
1np1A-4uw9A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8y CRISPR SYSTEM CMR
SUBUNIT CMR2


(Pyrococcus
furiosus)
PF12469
(DUF3692)
4 GLU A 332
LEU A 326
LEU A 329
LEU A 327
None
1.13A 1np1A-4w8yA:
undetectable
1np1A-4w8yA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbp CAPRIN-1

(Homo sapiens)
no annotation 4 GLU A 180
LEU A 186
LEU A 183
LEU A 185
None
1.04A 1np1A-4wbpA:
undetectable
1np1A-4wbpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvm STONUSTOXIN SUBUNIT
BETA


(Synanceia
horrida)
PF00622
(SPRY)
PF13765
(PRY)
4 GLU B 345
LEU B 339
LEU B 342
LEU B 340
None
1.08A 1np1A-4wvmB:
undetectable
1np1A-4wvmB:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwh ALPHA-N-ACETYLGLUCOS
AMINIDASE


(Homo sapiens)
PF05089
(NAGLU)
PF12971
(NAGLU_N)
PF12972
(NAGLU_C)
4 ASP A 607
LEU A 663
LEU A 618
LEU A 610
None
1.05A 1np1A-4xwhA:
undetectable
1np1A-4xwhA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymr PROTEIN SNX21

(Mus musculus)
no annotation 4 GLU A 297
LEU A 303
LEU A 300
LEU A 302
None
0.87A 1np1A-4ymrA:
undetectable
1np1A-4ymrA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c22 CHROMOSOMAL
HEMOLYSIN D


(Escherichia
coli)
PF13437
(HlyD_3)
4 GLU A 319
LEU A 313
LEU A 316
LEU A 314
None
1.17A 1np1A-5c22A:
undetectable
1np1A-5c22A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czy LEGIONELLA EFFECTOR
LEGAS4


(Legionella
pneumophila)
PF00023
(Ank)
PF00856
(SET)
4 ASP A 526
GLU A 525
LEU A 531
LEU A 528
None
1.11A 1np1A-5czyA:
undetectable
1np1A-5czyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22)
PF16510
(P22_portal)
4 GLU A 548
LEU A 554
LEU A 551
LEU A 553
None
0.95A 1np1A-5gaiA:
undetectable
1np1A-5gaiA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hs0 ANKYRIN DOMAIN
PROTEIN ANK1C4_7


(synthetic
construct)
PF12796
(Ank_2)
4 GLU A  13
LEU A   7
LEU A  10
LEU A   8
None
1.14A 1np1A-5hs0A:
undetectable
1np1A-5hs0A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hso UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887


(Mycobacterium
tuberculosis)
PF01047
(MarR)
4 GLU A  37
LEU A  28
LEU A  33
LEU A  35
None
1.13A 1np1A-5hsoA:
undetectable
1np1A-5hsoA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5izh RNA-DIRECTED RNA
POLYMERASE L


(Lassa
mammarenavirus)
PF17296
(ArenaCapSnatch)
4 GLU A  51
LEU A  45
LEU A  48
LEU A  46
None
1.03A 1np1A-5izhA:
undetectable
1np1A-5izhA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jld ARGINYL-TRNA
SYNTHETASE, PUTATIVE


(Plasmodium
falciparum)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
4 GLU A 580
LEU A 574
LEU A 577
LEU A 575
None
0.92A 1np1A-5jldA:
undetectable
1np1A-5jldA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf2 MINOR FIMBRIUM
SUBUNIT MFA1


(Porphyromonas
gingivalis)
no annotation 4 ASP A 139
GLU A  93
LEU A 147
LEU A 148
None
1.03A 1np1A-5nf2A:
undetectable
1np1A-5nf2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1


(Saccharomyces
cerevisiae)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
4 ASP T2198
GLU T2204
LEU T2210
LEU T2206
None
1.04A 1np1A-5ojsT:
undetectable
1np1A-5ojsT:
4.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oqr CONDENSIN COMPLEX
SUBUNIT 3


(Schizosaccharomyces
pombe)
no annotation 4 ASP A 636
LEU A 628
LEU A 632
LEU A 629
None
1.03A 1np1A-5oqrA:
undetectable
1np1A-5oqrA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sva MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 7


(Saccharomyces
cerevisiae)
PF05983
(Med7)
4 GLU U 180
LEU U 178
LEU U 177
LEU U 182
None
1.14A 1np1A-5svaU:
undetectable
1np1A-5svaU:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45


(Saccharomyces
cerevisiae)
PF02724
(CDC45)
4 GLU E 433
LEU E 546
LEU E 543
LEU E 545
None
0.79A 1np1A-5u8sE:
undetectable
1np1A-5u8sE:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45


(Saccharomyces
cerevisiae)
PF02724
(CDC45)
4 GLU E 433
LEU E 546
LEU E 543
LEU E 548
None
1.07A 1np1A-5u8sE:
undetectable
1np1A-5u8sE:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v1m U6 SNRNA
PHOSPHODIESTERASE


(Homo sapiens)
PF09749
(HVSL)
4 GLU A  93
LEU A  99
LEU A  96
LEU A  98
None
0.98A 1np1A-5v1mA:
undetectable
1np1A-5v1mA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vl1 LYSINE--TRNA LIGASE

(Mycobacterium
ulcerans)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 ASP A 453
GLU A 452
LEU A 458
LEU A 455
None
1.18A 1np1A-5vl1A:
undetectable
1np1A-5vl1A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
4 ASP C3354
GLU C3350
LEU C3298
LEU C3348
None
1.01A 1np1A-5y3rC:
undetectable
1np1A-5y3rC:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194)
4 GLU C  17
LEU C  12
LEU C  13
LEU C  15
None
1.14A 1np1A-5y3rC:
undetectable
1np1A-5y3rC:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E


(Mus musculus)
no annotation 4 ASP A 552
LEU A 504
LEU A 506
LEU A 550
None
1.13A 1np1A-5yudA:
undetectable
1np1A-5yudA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cet GATOR COMPLEX
PROTEIN NPRL3


(Homo sapiens)
no annotation 4 ASP M 266
LEU M 261
LEU M 264
LEU M 262
None
1.16A 1np1A-6cetM:
undetectable
1np1A-6cetM:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dex SUPPRESSOR OF
HYDROXYUREA
SENSITIVITY PROTEIN
1


(Eremothecium
gossypii)
no annotation 4 GLU A  28
LEU A  22
LEU A  25
LEU A  23
None
0.97A 1np1A-6dexA:
undetectable
1np1A-6dexA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fsa -

(-)
no annotation 4 GLU A 775
LEU A 769
LEU A 772
LEU A 770
None
0.99A 1np1A-6fsaA:
undetectable
1np1A-6fsaA:
undetectable