SIMILAR PATTERNS OF AMINO ACIDS FOR 1NP1_A_HSMA303
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cfz | HYDROGENASE 2MATURATION PROTEASE (Escherichiacoli) |
PF01750(HycI) | 4 | GLU A 81LEU A 116LEU A 77LEU A 114 | None | 0.85A | 1np1A-1cfzA:0.0 | 1np1A-1cfzA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f0x | D-LACTATEDEHYDROGENASE (Escherichiacoli) |
PF01565(FAD_binding_4)PF09330(Lact-deh-memb) | 4 | GLU A 512LEU A 518LEU A 515LEU A 517 | None | 0.93A | 1np1A-1f0xA:0.0 | 1np1A-1f0xA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ffw | CHEMOTAXIS PROTEINCHEA (Escherichiacoli) |
PF09078(CheY-binding) | 4 | GLU B 177LEU B 175LEU B 174LEU B 179 | None | 1.15A | 1np1A-1ffwB:0.0 | 1np1A-1ffwB:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1krt | LYSYL-TRNASYNTHETASE (PRODUCTOF LYSS GENE) (Escherichiacoli) |
PF01336(tRNA_anti-codon) | 4 | ASP A 120LEU A 145LEU A 122LEU A 146 | None | 1.08A | 1np1A-1krtA:0.0 | 1np1A-1krtA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1m3w | H10H24 (-) |
no annotation | 4 | GLU A 26LEU A 20LEU A 23LEU A 21 | None | 1.18A | 1np1A-1m3wA:undetectable | 1np1A-1m3wA:10.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1n | HYPOTHETICALZINC-TYPE ALCOHOLDEHYDROGENASE-LIKEPROTEIN IN PRE5-FET4INTERGENIC REGION (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLU A 316LEU A 310LEU A 313LEU A 311 | None | 1.15A | 1np1A-1q1nA:undetectable | 1np1A-1q1nA:18.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1s28 | ORF1 (Pseudomonassavastanoi) |
PF05932(CesT) | 4 | GLU A 124LEU A 118LEU A 121LEU A 119 | None | 0.99A | 1np1A-1s28A:undetectable | 1np1A-1s28A:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1skv | HYPOTHETICAL 7.5 KDAPROTEIN (Sulfolobusspindle-shapedvirus 1) |
no annotation | 4 | GLU A 27LEU A 21LEU A 24LEU A 22 | None | 1.16A | 1np1A-1skvA:undetectable | 1np1A-1skvA:16.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1u0x | NITROPHORIN 4 (Rhodniusprolixus) |
PF02087(Nitrophorin) | 4 | ASP A 30GLU A 32LEU A 123LEU A 133 | NoneNoneHEM A 185 (-4.4A)NH3 A 186 ( 4.8A) | 0.79A | 1np1A-1u0xA:32.1 | 1np1A-1u0xA:90.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wn1 | DIPEPTIDASE (Pyrococcushorikoshii) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 4 | GLU A 99LEU A 97LEU A 121LEU A 19 | None | 1.14A | 1np1A-1wn1A:undetectable | 1np1A-1wn1A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xxl | YCGJ PROTEIN (Bacillussubtilis) |
PF08241(Methyltransf_11) | 4 | ASP A 115GLU A 142LEU A 167LEU A 218 | NoneNoneSO4 A 404 (-4.6A)None | 1.10A | 1np1A-1xxlA:undetectable | 1np1A-1xxlA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ye8 | HYPOTHETICAL UPF0334KINASE-LIKE PROTEINAQ_1292 (Aquifexaeolicus) |
PF03266(NTPase_1) | 4 | GLU A 170LEU A 176LEU A 173LEU A 175 | None | 1.13A | 1np1A-1ye8A:undetectable | 1np1A-1ye8A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yke | RNA POLYMERASE IIMEDIATOR COMPLEXPROTEIN MED7 (Saccharomycescerevisiae) |
PF05983(Med7) | 4 | GLU A 180LEU A 178LEU A 177LEU A 182 | None | 1.14A | 1np1A-1ykeA:undetectable | 1np1A-1ykeA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yya | TRIOSEPHOSPHATEISOMERASE (Thermusthermophilus) |
PF00121(TIM) | 4 | GLU A 240LEU A 246LEU A 243LEU A 245 | None | 0.92A | 1np1A-1yyaA:undetectable | 1np1A-1yyaA:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yz6 | PROBABLE TRANSLATIONINITIATION FACTOR 2ALPHA SUBUNIT (Pyrococcusabyssi) |
PF00575(S1)PF07541(EIF_2_alpha) | 4 | GLU A 112LEU A 106LEU A 109LEU A 107 | None | 1.00A | 1np1A-1yz6A:undetectable | 1np1A-1yz6A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a9c | SULFITE OXIDASE (Gallus gallus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 4 | GLU A 169LEU A 153LEU A 165LEU A 167 | None | 0.98A | 1np1A-2a9cA:undetectable | 1np1A-2a9cA:16.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2btd | PTS-DEPENDENTDIHYDROXYACETONEKINASE (Escherichiacoli) |
PF02734(Dak2) | 4 | GLU A 105LEU A 3LEU A 101LEU A 103 | None | 0.88A | 1np1A-2btdA:undetectable | 1np1A-2btdA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dh3 | 4F2 CELL-SURFACEANTIGEN HEAVY CHAIN (Homo sapiens) |
PF00128(Alpha-amylase) | 4 | GLU A 504LEU A 522LEU A 496LEU A 523 | None | 1.08A | 1np1A-2dh3A:undetectable | 1np1A-2dh3A:17.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dq3 | SERYL-TRNASYNTHETASE (Aquifexaeolicus) |
PF00587(tRNA-synt_2b)PF02403(Seryl_tRNA_N) | 4 | ASP A 224GLU A 222LEU A 228LEU A 226 | None | 1.06A | 1np1A-2dq3A:undetectable | 1np1A-2dq3A:18.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e5v | L-ASPARTATE OXIDASE (Sulfurisphaeratokodaii) |
PF00890(FAD_binding_2)PF02910(Succ_DH_flav_C) | 4 | GLU A 131LEU A 125LEU A 128LEU A 126 | None | 1.15A | 1np1A-2e5vA:undetectable | 1np1A-2e5vA:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ebd | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 (Aquifexaeolicus) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 4 | GLU A 187LEU A 300LEU A 185LEU A 189 | None | 1.05A | 1np1A-2ebdA:undetectable | 1np1A-2ebdA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1r | MOLYBDOPTERIN-GUANINE DINUCLEOTIDEBIOSYNTHESIS PROTEINB (MOBB) (Archaeoglobusfulgidus) |
PF03205(MobB) | 4 | GLU A 154LEU A 160LEU A 157LEU A 159 | None | 0.97A | 1np1A-2f1rA:undetectable | 1np1A-2f1rA:18.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fup | HYPOTHETICAL PROTEINPA3352 (Pseudomonasaeruginosa) |
PF05130(FlgN) | 4 | GLU A 13LEU A 7LEU A 10LEU A 8 | None | 1.10A | 1np1A-2fupA:undetectable | 1np1A-2fupA:20.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4l | URIDYLATE KINASE (Sulfolobussolfataricus) |
PF00696(AA_kinase) | 4 | GLU A 61LEU A 67LEU A 64LEU A 66 | None | 1.16A | 1np1A-2j4lA:undetectable | 1np1A-2j4lA:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgn | ATP-DEPENDENT RNAHELICASE DDX3X (Homo sapiens) |
PF00271(Helicase_C) | 4 | GLU A 561LEU A 555LEU A 558LEU A 556 | None | 0.95A | 1np1A-2jgnA:undetectable | 1np1A-2jgnA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2mpc | PYRIN (Homo sapiens) |
PF02758(PYRIN) | 4 | GLU A 84LEU A 82LEU A 81LEU A 86 | None | 1.16A | 1np1A-2mpcA:undetectable | 1np1A-2mpcA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o16 | ACETOIN UTILIZATIONPROTEIN ACUB,PUTATIVE (Vibrio cholerae) |
PF00571(CBS) | 4 | GLU A 158LEU A 152LEU A 155LEU A 153 | None | 1.01A | 1np1A-2o16A:undetectable | 1np1A-2o16A:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q97 | TOXOFILIN (Toxoplasmagondii) |
no annotation | 4 | GLU T 114LEU T 112LEU T 111LEU T 116 | None | 1.16A | 1np1A-2q97T:undetectable | 1np1A-2q97T:16.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qyt | 2-DEHYDROPANTOATE2-REDUCTASE (Porphyromonasgingivalis) |
PF02558(ApbA)PF08546(ApbA_C) | 4 | GLU A 233LEU A 227LEU A 230LEU A 228 | None | 1.16A | 1np1A-2qytA:undetectable | 1np1A-2qytA:18.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v40 | ADENYLOSUCCINATESYNTHETASE ISOZYME 2 (Homo sapiens) |
PF00709(Adenylsucc_synt) | 4 | ASP A 212GLU A 214LEU A 220LEU A 217 | None | 1.07A | 1np1A-2v40A:undetectable | 1np1A-2v40A:19.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wdu | GLUTATHIONETRANSFERASE SIGMACLASS (Fasciolahepatica) |
PF14497(GST_C_3) | 4 | GLU A 141LEU A 135LEU A 138LEU A 136 | None | 1.17A | 1np1A-2wduA:undetectable | 1np1A-2wduA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wte | CSA3 (Sulfolobussolfataricus) |
no annotation | 4 | GLU A 21LEU A 15LEU A 18LEU A 16 | None | 1.01A | 1np1A-2wteA:undetectable | 1np1A-2wteA:22.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x1m | METHIONYL-TRNASYNTHETASE (Mycolicibacteriumsmegmatis) |
PF09334(tRNA-synt_1g) | 4 | GLU A 181LEU A 175LEU A 178LEU A 176 | None | 1.11A | 1np1A-2x1mA:undetectable | 1np1A-2x1mA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9y | ISWI ONE COMPLEXPROTEIN 3 (Saccharomycescerevisiae) |
PF15612(WHIM1) | 4 | GLU B 268LEU B 261LEU B 264LEU B 262 | None | 1.10A | 1np1A-2y9yB:undetectable | 1np1A-2y9yB:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywm | GLUTAREDOXIN-LIKEPROTEIN (Aquifexaeolicus) |
PF13192(Thioredoxin_3) | 4 | GLU A 125LEU A 131LEU A 128LEU A 130 | None | 1.01A | 1np1A-2ywmA:undetectable | 1np1A-2ywmA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3adr | PUTATIVEUNCHARACTERIZEDPROTEIN ST1585 (Sulfurisphaeratokodaii) |
PF00753(Lactamase_B) | 4 | ASP A 92GLU A 91LEU A 97LEU A 94 | EDO A 267 (-3.6A)NoneNoneEDO A 265 ( 4.5A) | 1.18A | 1np1A-3adrA:undetectable | 1np1A-3adrA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cai | POSSIBLEAMINOTRANSFERASE (Mycobacteriumtuberculosis) |
PF00266(Aminotran_5) | 4 | GLU A 96LEU A 90LEU A 93LEU A 91 | None | 0.95A | 1np1A-3caiA:undetectable | 1np1A-3caiA:18.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dka | DINB-LIKE PROTEIN (Bacillussubtilis) |
PF05163(DinB) | 4 | GLU A 126LEU A 120LEU A 123LEU A 121 | None | 0.89A | 1np1A-3dkaA:undetectable | 1np1A-3dkaA:23.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2k | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF01359(Transposase_1) | 4 | GLU A 150LEU A 128LEU A 152LEU A 127 | None | 1.05A | 1np1A-3f2kA:undetectable | 1np1A-3f2kA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g68 | PUTATIVEPHOSPHOSUGARISOMERASE (Clostridioidesdifficile) |
PF01380(SIS) | 4 | GLU A 224LEU A 230LEU A 227LEU A 229 | None | 1.11A | 1np1A-3g68A:undetectable | 1np1A-3g68A:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gxo | MMCR (Streptomyceslavendulae) |
PF00891(Methyltransf_2) | 4 | GLU A 235LEU A 212LEU A 237LEU A 211 | None | 0.90A | 1np1A-3gxoA:undetectable | 1np1A-3gxoA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 4 | GLU A 419LEU A 413LEU A 416LEU A 414 | None | 1.06A | 1np1A-3hmjA:undetectable | 1np1A-3hmjA:6.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3isu | RASGTPASE-ACTIVATING-LIKE PROTEIN IQGAP3 (Homo sapiens) |
no annotation | 4 | GLU A1602LEU A1596LEU A1599LEU A1597 | None | 1.15A | 1np1A-3isuA:undetectable | 1np1A-3isuA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3izq | ELONGATION FACTOR 1ALPHA-LIKE PROTEIN (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3)PF08938(HBS1_N) | 4 | ASP 1 66GLU 1 68LEU 1 74LEU 1 71 | None | 1.13A | 1np1A-3izq1:undetectable | 1np1A-3izq1:15.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lhx | KETODEOXYGLUCONOKINASE (Shigellaflexneri) |
PF00294(PfkB) | 4 | GLU A 228LEU A 222LEU A 225LEU A 223 | None | 0.98A | 1np1A-3lhxA:undetectable | 1np1A-3lhxA:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lij | CALCIUM/CALMODULINDEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase)PF13499(EF-hand_7) | 4 | GLU A 149LEU A 190LEU A 146LEU A 191 | NoneNoneNoneANP A 522 (-4.7A) | 0.97A | 1np1A-3lijA:undetectable | 1np1A-3lijA:18.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mg6 | PROTEASOME COMPONENTC11 (Saccharomycescerevisiae) |
PF00227(Proteasome) | 4 | GLU J 149LEU J 155LEU J 152LEU J 154 | None | 0.98A | 1np1A-3mg6J:undetectable | 1np1A-3mg6J:23.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mv3 | COATOMER SUBUNITEPSILON (Saccharomycescerevisiae) |
PF04733(Coatomer_E) | 4 | GLU B 130LEU B 124LEU B 127LEU B 125 | None | 0.93A | 1np1A-3mv3B:undetectable | 1np1A-3mv3B:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pdi | NITROGENASE MOFECOFACTORBIOSYNTHESIS PROTEINNIFE (Azotobactervinelandii) |
PF00148(Oxidored_nitro) | 4 | ASP A 390GLU A 391LEU A 385LEU A 386 | None | 1.15A | 1np1A-3pdiA:undetectable | 1np1A-3pdiA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pfs | BROMODOMAIN AND PHDFINGER-CONTAININGPROTEIN 3 (Homo sapiens) |
PF00855(PWWP) | 4 | ASP A1163GLU A1159LEU A1154LEU A1156 | None | 1.09A | 1np1A-3pfsA:undetectable | 1np1A-3pfsA:22.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r18 | SULFITE OXIDASE (Gallus gallus) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 4 | GLU A 169LEU A 153LEU A 165LEU A 167 | None | 0.87A | 1np1A-3r18A:undetectable | 1np1A-3r18A:17.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rgc | POSSIBLE PERIPLASMICPROTEIN (Campylobacterjejuni) |
PF09312(SurA_N) | 4 | GLU A 240LEU A 196LEU A 199LEU A 197 | None | 1.04A | 1np1A-3rgcA:undetectable | 1np1A-3rgcA:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sxf | CALMODULIN-DOMAINPROTEIN KINASE 1 (Toxoplasmagondii) |
PF00069(Pkinase)PF13499(EF-hand_7) | 4 | GLU A 139LEU A 180LEU A 136LEU A 181 | None | 1.17A | 1np1A-3sxfA:undetectable | 1np1A-3sxfA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqf | HPR(SER) KINASE (Coxiellaburnetii) |
PF07475(Hpr_kinase_C) | 4 | GLU A 157LEU A 155LEU A 154LEU A 159 | None | 1.17A | 1np1A-3tqfA:undetectable | 1np1A-3tqfA:24.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u4f | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Roseovariusnubinhibens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | GLU A 68LEU A 62LEU A 65LEU A 63 | None | 1.18A | 1np1A-3u4fA:undetectable | 1np1A-3u4fA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwx | S12 FAMILY PEPTIDASE (Streptomycessp. 82F2) |
PF00144(Beta-lactamase) | 4 | GLU A 102LEU A 96LEU A 99LEU A 97 | None | 1.14A | 1np1A-3wwxA:undetectable | 1np1A-3wwxA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x1l | CRISPR SYSTEM CMRSUBUNIT CMR2 (Pyrococcusfuriosus) |
PF12469(DUF3692) | 4 | GLU A 332LEU A 326LEU A 329LEU A 327 | None | 1.15A | 1np1A-3x1lA:undetectable | 1np1A-3x1lA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a0h | ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE (Arabidopsisthaliana) |
PF00202(Aminotran_3)PF13500(AAA_26) | 4 | GLU A 129LEU A 52LEU A 131LEU A 51 | None | 1.12A | 1np1A-4a0hA:undetectable | 1np1A-4a0hA:13.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgs | POLYMERASE SUBUNITPA (Dhorithogotovirus) |
no annotation | 4 | GLU A 157LEU A 161LEU A 156LEU A 160 | None | 0.84A | 1np1A-4cgsA:undetectable | 1np1A-4cgsA:18.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fl3 | TYROSINE-PROTEINKINASE SYK (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 4 | GLU A 452LEU A 502LEU A 453LEU A 501 | NoneNoneNoneANP A 701 (-4.5A) | 1.12A | 1np1A-4fl3A:undetectable | 1np1A-4fl3A:14.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gax | AMORPHA-4,11-DIENESYNTHASE (Artemisia annua) |
PF01397(Terpene_synth)PF03936(Terpene_synth_C) | 4 | GLU A 69LEU A 63LEU A 66LEU A 64 | None | 1.05A | 1np1A-4gaxA:undetectable | 1np1A-4gaxA:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4htt | SEC-INDEPENDENTPROTEIN TRANSLOCASEPROTEIN TATC,LYSOZYME (Aquifexaeolicus;Escherichiavirus T4) |
PF00902(TatC) | 4 | GLU A 221LEU A 216LEU A 217LEU A 219 | None | 1.01A | 1np1A-4httA:undetectable | 1np1A-4httA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i2w | PROTEIN UNC-45 (Caenorhabditiselegans) |
PF11701(UNC45-central) | 4 | GLU A 173LEU A 167LEU A 170LEU A 168 | None | 1.07A | 1np1A-4i2wA:undetectable | 1np1A-4i2wA:11.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jmk | DUAL SPECIFICITYPROTEIN PHOSPHATASE8 (Homo sapiens) |
PF00782(DSPc) | 4 | GLU A 297LEU A 303LEU A 300LEU A 302 | None | 1.01A | 1np1A-4jmkA:undetectable | 1np1A-4jmkA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k6n | AMINODEOXYCHORISMATELYASE (Saccharomycescerevisiae) |
PF01063(Aminotran_4) | 4 | GLU A 153LEU A 147LEU A 150LEU A 148 | None | 1.18A | 1np1A-4k6nA:undetectable | 1np1A-4k6nA:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m0k | ADENINEPHOSPHORIBOSYLTRANSFERASE (Rhodothermusmarinus) |
PF00156(Pribosyltran) | 4 | GLU A 44LEU A 38LEU A 41LEU A 39 | None | 1.08A | 1np1A-4m0kA:undetectable | 1np1A-4m0kA:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mni | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Polaromonas sp.JS666) |
PF03480(DctP) | 4 | GLU A 263LEU A 257LEU A 260LEU A 258 | None | 1.03A | 1np1A-4mniA:undetectable | 1np1A-4mniA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nnd | TYROSINE-PROTEINPHOSPHATASENON-RECEPTOR TYPE 18 (Homo sapiens) |
PF00102(Y_phosphatase) | 4 | ASP A 114LEU A 77LEU A 78LEU A 75 | None | 0.93A | 1np1A-4nndA:undetectable | 1np1A-4nndA:18.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oby | ARGININE--TRNALIGASE (Escherichiacoli) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 4 | GLU A 396LEU A 394LEU A 393LEU A 398 | None | 1.11A | 1np1A-4obyA:undetectable | 1np1A-4obyA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p7h | MYOSIN-7,GREENFLUORESCENT PROTEIN (Aequoreavictoria;Homo sapiens) |
PF00063(Myosin_head)PF01353(GFP)PF02736(Myosin_N) | 4 | GLU A 775LEU A 769LEU A 772LEU A 770 | None | 1.17A | 1np1A-4p7hA:undetectable | 1np1A-4p7hA:12.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q2q | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00595(PDZ) | 4 | GLU A 481LEU A 487LEU A 484LEU A 486 | None | 0.99A | 1np1A-4q2qA:undetectable | 1np1A-4q2qA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4reu | FERRITIN (Escherichiacoli) |
PF00210(Ferritin) | 4 | ASP A 155GLU A 37LEU A 43LEU A 158 | None | 0.96A | 1np1A-4reuA:undetectable | 1np1A-4reuA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4um2 | TELOMERASE-BINDINGPROTEIN EST1A (Homo sapiens) |
PF10373(EST1_DNA_bind)PF10374(EST1) | 4 | GLU A 680LEU A 674LEU A 677LEU A 675 | None | 1.00A | 1np1A-4um2A:undetectable | 1np1A-4um2A:16.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uw9 | BETA-PHOSPHOGLUCOMUTASE (Pyrococcus sp.ST04) |
PF13419(HAD_2) | 4 | GLU A 69LEU A 75LEU A 72LEU A 74 | None | 1.05A | 1np1A-4uw9A:undetectable | 1np1A-4uw9A:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w8y | CRISPR SYSTEM CMRSUBUNIT CMR2 (Pyrococcusfuriosus) |
PF12469(DUF3692) | 4 | GLU A 332LEU A 326LEU A 329LEU A 327 | None | 1.13A | 1np1A-4w8yA:undetectable | 1np1A-4w8yA:13.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wbp | CAPRIN-1 (Homo sapiens) |
no annotation | 4 | GLU A 180LEU A 186LEU A 183LEU A 185 | None | 1.04A | 1np1A-4wbpA:undetectable | 1np1A-4wbpA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvm | STONUSTOXIN SUBUNITBETA (Synanceiahorrida) |
PF00622(SPRY)PF13765(PRY) | 4 | GLU B 345LEU B 339LEU B 342LEU B 340 | None | 1.08A | 1np1A-4wvmB:undetectable | 1np1A-4wvmB:14.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xwh | ALPHA-N-ACETYLGLUCOSAMINIDASE (Homo sapiens) |
PF05089(NAGLU)PF12971(NAGLU_N)PF12972(NAGLU_C) | 4 | ASP A 607LEU A 663LEU A 618LEU A 610 | None | 1.05A | 1np1A-4xwhA:undetectable | 1np1A-4xwhA:12.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ymr | PROTEIN SNX21 (Mus musculus) |
no annotation | 4 | GLU A 297LEU A 303LEU A 300LEU A 302 | None | 0.87A | 1np1A-4ymrA:undetectable | 1np1A-4ymrA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c22 | CHROMOSOMALHEMOLYSIN D (Escherichiacoli) |
PF13437(HlyD_3) | 4 | GLU A 319LEU A 313LEU A 316LEU A 314 | None | 1.17A | 1np1A-5c22A:undetectable | 1np1A-5c22A:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5czy | LEGIONELLA EFFECTORLEGAS4 (Legionellapneumophila) |
PF00023(Ank)PF00856(SET) | 4 | ASP A 526GLU A 525LEU A 531LEU A 528 | None | 1.11A | 1np1A-5czyA:undetectable | 1np1A-5czyA:16.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gai | PORTAL PROTEIN (Salmonellavirus P22) |
PF16510(P22_portal) | 4 | GLU A 548LEU A 554LEU A 551LEU A 553 | None | 0.95A | 1np1A-5gaiA:undetectable | 1np1A-5gaiA:14.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hs0 | ANKYRIN DOMAINPROTEIN ANK1C4_7 (syntheticconstruct) |
PF12796(Ank_2) | 4 | GLU A 13LEU A 7LEU A 10LEU A 8 | None | 1.14A | 1np1A-5hs0A:undetectable | 1np1A-5hs0A:22.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hso | UNCHARACTERIZEDHTH-TYPETRANSCRIPTIONALREGULATOR RV2887 (Mycobacteriumtuberculosis) |
PF01047(MarR) | 4 | GLU A 37LEU A 28LEU A 33LEU A 35 | None | 1.13A | 1np1A-5hsoA:undetectable | 1np1A-5hsoA:18.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5izh | RNA-DIRECTED RNAPOLYMERASE L (Lassamammarenavirus) |
PF17296(ArenaCapSnatch) | 4 | GLU A 51LEU A 45LEU A 48LEU A 46 | None | 1.03A | 1np1A-5izhA:undetectable | 1np1A-5izhA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jld | ARGINYL-TRNASYNTHETASE, PUTATIVE (Plasmodiumfalciparum) |
PF00750(tRNA-synt_1d)PF03485(Arg_tRNA_synt_N)PF05746(DALR_1) | 4 | GLU A 580LEU A 574LEU A 577LEU A 575 | None | 0.92A | 1np1A-5jldA:undetectable | 1np1A-5jldA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nf2 | MINOR FIMBRIUMSUBUNIT MFA1 (Porphyromonasgingivalis) |
no annotation | 4 | ASP A 139GLU A 93LEU A 147LEU A 148 | None | 1.03A | 1np1A-5nf2A:undetectable | 1np1A-5nf2A:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ojs | TRANSCRIPTION-ASSOCIATED PROTEIN 1 (Saccharomycescerevisiae) |
PF00454(PI3_PI4_kinase)PF02259(FAT) | 4 | ASP T2198GLU T2204LEU T2210LEU T2206 | None | 1.04A | 1np1A-5ojsT:undetectable | 1np1A-5ojsT:4.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oqr | CONDENSIN COMPLEXSUBUNIT 3 (Schizosaccharomycespombe) |
no annotation | 4 | ASP A 636LEU A 628LEU A 632LEU A 629 | None | 1.03A | 1np1A-5oqrA:undetectable | 1np1A-5oqrA:14.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5sva | MEDIATOR OF RNAPOLYMERASE IITRANSCRIPTIONSUBUNIT 7 (Saccharomycescerevisiae) |
PF05983(Med7) | 4 | GLU U 180LEU U 178LEU U 177LEU U 182 | None | 1.14A | 1np1A-5svaU:undetectable | 1np1A-5svaU:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8s | CELL DIVISIONCONTROL PROTEIN 45 (Saccharomycescerevisiae) |
PF02724(CDC45) | 4 | GLU E 433LEU E 546LEU E 543LEU E 545 | None | 0.79A | 1np1A-5u8sE:undetectable | 1np1A-5u8sE:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8s | CELL DIVISIONCONTROL PROTEIN 45 (Saccharomycescerevisiae) |
PF02724(CDC45) | 4 | GLU E 433LEU E 546LEU E 543LEU E 548 | None | 1.07A | 1np1A-5u8sE:undetectable | 1np1A-5u8sE:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v1m | U6 SNRNAPHOSPHODIESTERASE (Homo sapiens) |
PF09749(HVSL) | 4 | GLU A 93LEU A 99LEU A 96LEU A 98 | None | 0.98A | 1np1A-5v1mA:undetectable | 1np1A-5v1mA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vl1 | LYSINE--TRNA LIGASE (Mycobacteriumulcerans) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 4 | ASP A 453GLU A 452LEU A 458LEU A 455 | None | 1.18A | 1np1A-5vl1A:undetectable | 1np1A-5vl1A:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 4 | ASP C3354GLU C3350LEU C3298LEU C3348 | None | 1.01A | 1np1A-5y3rC:undetectable | 1np1A-5y3rC:4.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y3r | DNA-DEPENDENTPROTEIN KINASECATALYTIC SUBUNIT (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF02259(FAT)PF02260(FATC)PF08163(NUC194) | 4 | GLU C 17LEU C 12LEU C 13LEU C 15 | None | 1.14A | 1np1A-5y3rC:undetectable | 1np1A-5y3rC:4.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yud | BACULOVIRAL IAPREPEAT-CONTAININGPROTEIN 1E (Mus musculus) |
no annotation | 4 | ASP A 552LEU A 504LEU A 506LEU A 550 | None | 1.13A | 1np1A-5yudA:undetectable | 1np1A-5yudA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cet | GATOR COMPLEXPROTEIN NPRL3 (Homo sapiens) |
no annotation | 4 | ASP M 266LEU M 261LEU M 264LEU M 262 | None | 1.16A | 1np1A-6cetM:undetectable | 1np1A-6cetM:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6dex | SUPPRESSOR OFHYDROXYUREASENSITIVITY PROTEIN1 (Eremotheciumgossypii) |
no annotation | 4 | GLU A 28LEU A 22LEU A 25LEU A 23 | None | 0.97A | 1np1A-6dexA:undetectable | 1np1A-6dexA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fsa | - (-) |
no annotation | 4 | GLU A 775LEU A 769LEU A 772LEU A 770 | None | 0.99A | 1np1A-6fsaA:undetectable | 1np1A-6fsaA:undetectable |