SIMILAR PATTERNS OF AMINO ACIDS FOR 1NNC_A_ZMRA479_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7h ADENYLYLSULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		4 ASP A 112
ARG A 113
TRP A  29
ILE A  87
 None
 1.50A 1nncA-1m7hA:
undetectable		 1nncA-1m7hA:
18.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1nmb N9 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP N 151
ARG N 156
TRP N 178
ILE N 222
 None
 0.68A 1nncA-1nmbN:
73.6		 1nncA-1nmbN:
96.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1v0z NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 157
ARG A 162
TRP A 185
ILE A 229
 None
 0.18A 1nncA-1v0zA:
72.4		 1nncA-1v0zA:
69.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vcj NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 ASP A 149
ARG A 154
TRP A 177
ILE A 221
 IBA  A   1 (-3.6A)
IBA  A   1 (-4.1A)
None
IBA  A   1 ( 4.3A)
 0.47A 1nncA-1vcjA:
53.5		 1nncA-1vcjA:
30.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xog NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 152
ARG A 157
TRP A 180
ILE A 224
 ABW  A1000 (-3.7A)
ABW  A1000 (-4.2A)
None
ABW  A1000 ( 4.7A)
 0.41A 1nncA-1xogA:
73.3		 1nncA-1xogA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 PUTATIVE
SULFURTRANSFERASE
DSRE

(Allochromatium
vinosum) 		PF02635
(DrsE) 		4 ASP A  18
ARG A  63
TRP A  64
ILE A   7
 None
 1.42A 1nncA-2hy5A:
undetectable		 1nncA-2hy5A:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ASP A 177
ARG A 126
TRP A 340
ILE A 343
 None
 1.49A 1nncA-2q1fA:
undetectable		 1nncA-2q1fA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ckz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 ZMR  A 469 (-3.5A)
ZMR  A 469 (-3.4A)
None
None
 0.73A 1nncA-3ckzA:
63.9		 1nncA-3ckzA:
48.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 LNV  A 901 (-3.4A)
LNV  A 901 (-4.0A)
None
None
 0.14A 1nncA-3ti8A:
64.3		 1nncA-3ti8A:
43.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tia NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 LNV  A 801 (-3.4A)
LNV  A 801 (-4.0A)
None
None
 0.11A 1nncA-3tiaA:
64.7		 1nncA-3tiaA:
41.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpn NEURAMINIDASE

(Influenza B
virus) 		PF00064
(Neur) 		4 ASP A 148
ARG A 153
TRP A 176
ILE A 220
 ZMR  A 700 (-3.3A)
ZMR  A 700 (-4.2A)
None
None
 0.15A 1nncA-4cpnA:
54.0		 1nncA-4cpnA:
28.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4h53 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 SLB  A 512 (-3.5A)
None
None
None
 0.16A 1nncA-4h53A:
64.6		 1nncA-4h53A:
49.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4hzz NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 G39  A 509 (-3.6A)
None
None
G39  A 509 ( 4.1A)
 0.15A 1nncA-4hzzA:
62.7		 1nncA-4hzzA:
48.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4mju NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 27S  A 501 (-3.2A)
None
None
27S  A 501 ( 4.6A)
 0.71A 1nncA-4mjuA:
61.9		 1nncA-4mjuA:
43.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qn3 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		4 ASP A  69
ARG A  74
TRP A  97
ILE A 141
 None
 0.28A 1nncA-4qn3A:
70.9		 1nncA-4qn3A:
61.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6br6 NEURAMINIDASE

(Influenza A
virus) 		no annotation 4 ASP A 151
ARG A 156
TRP A 178
ILE A 222
 E3M  A 511 (-2.9A)
None
None
E3M  A 511 ( 4.3A)
 0.18A 1nncA-6br6A:
64.3		 1nncA-6br6A:
20.97