SIMILAR PATTERNS OF AMINO ACIDS FOR 1NHZ_A_486A800_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuz ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE F2

(Streptococcus
pyogenes) 		no annotation 4 TRP A 388
MET A 325
PHE A 400
TYR A 332
 None
 1.46A 1nhzA-4nuzA:
0.0		 1nhzA-4nuzA:
14.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 TRP A 600
MET A 601
PHE A 623
TYR A 735
 None
MOF  A 801 (-3.7A)
MOF  A 801 (-4.7A)
MOF  A 801 (-4.8A)
 1.16A 1nhzA-4p6wA:
31.4		 1nhzA-4p6wA:
96.83