SIMILAR PATTERNS OF AMINO ACIDS FOR 1NHZ_A_486A800_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1agr RGS4

(Rattus
norvegicus) 		PF00615
(RGS) 		5 LEU E  73
GLY E  72
LEU E  63
MET E 160
LEU E  80
 None
 1.34A 1nhzA-1agrE:
undetectable		 1nhzA-1agrE:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		5 MET A  93
GLN A  83
VAL A  82
LEU A   4
GLN A 120
 None
 1.16A 1nhzA-1ayeA:
undetectable		 1nhzA-1ayeA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE

(Medicago sativa) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 MET A  75
LEU A  78
GLY A  82
LEU A 103
LEU A  96
 None
 1.26A 1nhzA-1fp2A:
undetectable		 1nhzA-1fp2A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4y ANTI-SIGMA F FACTOR
ANTAGONIST

(Lysinibacillus
sphaericus) 		PF01740
(STAS) 		5 MET A  99
LEU A  79
VAL A  14
MET A  55
LEU A  52
 None
 1.24A 1nhzA-1h4yA:
undetectable		 1nhzA-1h4yA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		5 LEU A  76
ASN A  75
GLY A  70
LEU A  61
LEU A  45
 None
 1.39A 1nhzA-1h76A:
undetectable		 1nhzA-1h76A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jk0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 2

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		5 LEU B  85
ASN B  84
GLY B  83
LEU B 209
LEU B  74
 None
 1.45A 1nhzA-1jk0B:
undetectable		 1nhzA-1jk0B:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnf SEROTRANSFERRIN

(Oryctolagus
cuniculus) 		PF00405
(Transferrin) 		5 LEU A  77
ASN A  76
GLY A  71
LEU A  62
LEU A  46
 None
 1.37A 1nhzA-1jnfA:
undetectable		 1nhzA-1jnfA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lme PEPTIDE DEFORMYLASE

(Thermotoga
maritima) 		PF01327
(Pep_deformylase) 		5 MET A  33
LEU A  45
GLY A  44
VAL A 126
LEU A 134
 None
 1.41A 1nhzA-1lmeA:
undetectable		 1nhzA-1lmeA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqw PEPTIDE DEFORMYLASE
PDF1

(Staphylococcus
aureus) 		PF01327
(Pep_deformylase) 		5 MET A  37
LEU A  61
GLY A  60
VAL A 151
LEU A 159
 None
 1.38A 1nhzA-1lqwA:
undetectable		 1nhzA-1lqwA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
LEU A 346
LEU A 391
ARG A 394
LEU A 384
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
None
 1.22A 1nhzA-1pcgA:
22.9		 1nhzA-1pcgA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		5 MET A  69
LEU A  89
GLN A 344
VAL A 343
LEU A 331
 None
 1.20A 1nhzA-1pjbA:
undetectable		 1nhzA-1pjbA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN

(Escherichia
coli) 		PF00268
(Ribonuc_red_sm) 		5 LEU A 197
ASN A 201
LEU A 104
MET A  17
LEU A 251
 None
 1.36A 1nhzA-1pm2A:
undetectable		 1nhzA-1pm2A:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtp LMAJ004091AAA

(Leishmania
major) 		PF05891
(Methyltransf_PK) 		5 LEU A  68
GLY A  66
VAL A  60
MET A 128
GLN A 165
 None
None
None
SAI  A 401 ( 4.9A)
SAI  A 401 (-4.6A)
 1.43A 1nhzA-1xtpA:
undetectable		 1nhzA-1xtpA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a22 VACUOLAR PROTEIN
SORTING 29

(Cryptosporidium
parvum) 		PF12850
(Metallophos_2) 		5 GLY A  98
VAL A  89
LEU A  11
MET A 168
LEU A 170
 None
 1.43A 1nhzA-2a22A:
undetectable		 1nhzA-2a22A:
20.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 GLY A 708
GLN A 711
MET A 745
ARG A 752
LEU A 873
 BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-4.4A)
 0.74A 1nhzA-2ax9A:
27.9		 1nhzA-2ax9A:
46.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ax9 ANDROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 704
ASN A 705
GLY A 708
GLN A 711
MET A 745
ARG A 752
MET A 787
 BHM  A   1 (-4.0A)
BHM  A   1 (-3.6A)
BHM  A   1 ( 3.8A)
BHM  A   1 (-2.2A)
BHM  A   1 (-3.9A)
BHM  A   1 (-3.8A)
BHM  A   1 (-3.6A)
 1.00A 1nhzA-2ax9A:
27.9		 1nhzA-2ax9A:
46.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 LEU A 357
GLY A  93
VAL A 254
GLN A 270
LEU A 272
 None
 1.38A 1nhzA-2de2A:
undetectable		 1nhzA-2de2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gyt DELETED IN LIVER
CANCER 1 PROTEIN,
ISOFORM 2

(Homo sapiens) 		PF07647
(SAM_2) 		5 LEU A  66
ASN A  67
VAL A  74
LEU A  34
LEU A  46
 None
 1.29A 1nhzA-2gytA:
undetectable		 1nhzA-2gytA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 LEU B1161
GLY B1192
LEU B1199
MET B1205
LEU B1152
 None
 1.30A 1nhzA-2nvuB:
undetectable		 1nhzA-2nvuB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 LEU B1161
VAL B1358
LEU B1199
MET B1205
LEU B1152
 None
 1.38A 1nhzA-2nvuB:
undetectable		 1nhzA-2nvuB:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 MET A 343
LEU A 346
LEU A 391
ARG A 394
LEU A 384
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
None
 1.14A 1nhzA-2ocfA:
23.8		 1nhzA-2ocfA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oj4 REGULATOR OF
G-PROTEIN SIGNALING
3

(Homo sapiens) 		PF00615
(RGS) 		5 LEU A  22
GLY A  21
LEU A  12
MET A 109
LEU A  29
 None
 1.28A 1nhzA-2oj4A:
undetectable		 1nhzA-2oj4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		5 LEU A  69
GLY A  71
VAL A  73
LEU A  92
LEU A 162
 None
 1.41A 1nhzA-2prdA:
undetectable		 1nhzA-2prdA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		6 ASN A  33
GLN A  39
MET A  73
LEU A  77
ARG A  80
MET A 115
 1CA  A 247 (-2.9A)
1CA  A 247 (-3.1A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
 0.87A 1nhzA-2q3yA:
30.3		 1nhzA-2q3yA:
58.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		7 LEU A  32
GLN A  39
MET A  73
LEU A  77
ARG A  80
MET A 115
LEU A 201
 1CA  A 247 (-4.0A)
1CA  A 247 (-3.1A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
1CA  A 247 ( 3.7A)
1CA  A 247 ( 4.2A)
 0.57A 1nhzA-2q3yA:
30.3		 1nhzA-2q3yA:
58.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzu PUTATIVE SULFATASE
YIDJ

(Bacteroides
fragilis) 		PF00884
(Sulfatase) 		5 LEU A  83
GLY A  86
VAL A 379
LEU A 365
LEU A 120
 None
 1.33A 1nhzA-2qzuA:
undetectable		 1nhzA-2qzuA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wl8 PEROXISOMAL
BIOGENESIS FACTOR 19

(Homo sapiens) 		PF04614
(Pex19) 		5 LEU A 268
GLY A 270
GLN A 221
MET A 225
LEU A 258
 None
 1.36A 1nhzA-2wl8A:
undetectable		 1nhzA-2wl8A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 GLY A 436
VAL A 883
MET A 773
LEU A 772
LEU A 779
 None
 1.09A 1nhzA-2xvgA:
undetectable		 1nhzA-2xvgA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y05 PROSTAGLANDIN
REDUCTASE 1

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A 322
ASN A 321
GLY A 152
VAL A 154
LEU A 185
 None
NAP  A 701 (-3.1A)
NAP  A 701 (-3.1A)
NAP  A 701 (-3.7A)
None
 1.29A 1nhzA-2y05A:
undetectable		 1nhzA-2y05A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d01 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF14588
(YjgF_endoribonc) 		5 LEU A 128
ASN A 127
GLY A 124
VAL A 121
LEU A  79
 None
 1.36A 1nhzA-3d01A:
undetectable		 1nhzA-3d01A:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY

(Acinetobacter
sp. ADP1) 		no annotation 5 LEU A 159
GLY A 161
MET A 138
MET A  64
LEU A 126
 None
 1.41A 1nhzA-3d3oA:
undetectable		 1nhzA-3d3oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3o PUTATIVE
TRANSCRIPTIONAL
REGULATOR, ICIR
FAMILY

(Acinetobacter
sp. ADP1) 		no annotation 5 LEU A 159
GLY A 161
VAL A  10
MET A 138
LEU A 126
 None
 1.35A 1nhzA-3d3oA:
undetectable		 1nhzA-3d3oA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 LEU A-189
VAL A   8
LEU A-151
MET A-145
LEU A-198
 None
 1.44A 1nhzA-3ehsA:
undetectable		 1nhzA-3ehsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h68 SERINE/THREONINE-PRO
TEIN PHOSPHATASE 5

(Homo sapiens) 		PF00149
(Metallophos)
PF08321
(PPP5) 		5 LEU A 286
GLY A 288
VAL A 186
MET A 191
LEU A 259
 None
 1.40A 1nhzA-3h68A:
undetectable		 1nhzA-3h68A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjn THYMIDYLATE KINASE

(Thermotoga
maritima) 		PF02223
(Thymidylate_kin) 		5 ASN A 103
GLY A  99
GLN A  98
VAL A  95
LEU A 151
 None
None
TYD  A 401 (-3.0A)
None
None
 1.35A 1nhzA-3hjnA:
undetectable		 1nhzA-3hjnA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iey NEQ261
TRNA-SPLICING
ENDONUCLEASE

(Nanoarchaeum
equitans) 		PF01974
(tRNA_int_endo)
PF02778
(tRNA_int_endo_N) 		5 LEU A 136
GLY A 138
VAL A 140
ARG B 150
LEU A  73
 None
 1.10A 1nhzA-3ieyA:
undetectable		 1nhzA-3ieyA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3im8 MALONYL ACYL CARRIER
PROTEIN TRANSACYLASE

(Streptococcus
pneumoniae) 		PF00698
(Acyl_transf_1) 		5 ASN A 229
VAL A  86
LEU A 103
GLN A  62
LEU A  66
 None
None
None
ACT  A 500 ( 4.2A)
None
 1.42A 1nhzA-3im8A:
undetectable		 1nhzA-3im8A:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9p MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY A
MEMBER 1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 LEU D 955
ASN D 954
GLY D 958
VAL D 961
LEU D 870
 None
 1.36A 1nhzA-3j9pD:
undetectable		 1nhzA-3j9pD:
11.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 ASN A 719
GLY A 722
GLN A 725
MET A 759
ARG A 766
LEU A 887
 WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 ( 4.1A)
WOW  A   1 (-3.7A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.0A)
 1.21A 1nhzA-3kbaA:
29.6		 1nhzA-3kbaA:
49.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 LEU A 718
ASN A 719
GLY A 722
MET A 759
LEU A 763
ARG A 766
MET A 801
LEU A 887
 WOW  A   1 (-4.2A)
WOW  A   1 (-3.3A)
WOW  A   1 ( 4.3A)
WOW  A   1 (-3.7A)
WOW  A   1 ( 4.0A)
WOW  A   1 (-3.8A)
WOW  A   1 (-4.2A)
WOW  A   1 (-4.0A)
 0.95A 1nhzA-3kbaA:
29.6		 1nhzA-3kbaA:
49.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 LEU E  41
ASN E  42
GLY E 107
VAL E  65
LEU E 153
 None
 1.44A 1nhzA-3kfuE:
undetectable		 1nhzA-3kfuE:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxy EXOENZYME S
SYNTHESIS PROTEIN C
EXSE

(Pseudomonas
aeruginosa) 		PF05932
(CesT)
no annotation 		5 ASN A  76
GLY A  87
VAL A  95
ARG T  38
LEU A 118
 None
 1.17A 1nhzA-3kxyA:
undetectable		 1nhzA-3kxyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 LEU A 431
ASN A 430
GLY A 433
VAL A 380
LEU A 385
 None
 1.39A 1nhzA-3oc4A:
undetectable		 1nhzA-3oc4A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfq PTERIN-4-ALPHA-CARBI
NOLAMINE DEHYDRATASE
MOAB2

(Mycobacterium
marinum) 		PF00994
(MoCF_biosynth) 		5 LEU A  87
VAL A  63
LEU A 151
MET A 162
LEU A  52
 None
 1.41A 1nhzA-3rfqA:
undetectable		 1nhzA-3rfqA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ri5 MOUSE MONOCLONAL FAB
FRAGMENT, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ASN K  36
GLY K  48
VAL K  60
GLN K   6
LEU K  20
 None
 1.23A 1nhzA-3ri5K:
undetectable		 1nhzA-3ri5K:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rip GAMMA-TUBULIN
COMPLEX COMPONENT 4

(Homo sapiens) 		PF04130
(Spc97_Spc98) 		5 LEU A 196
GLY A 194
VAL A 283
GLN A 186
LEU A 187
 None
 1.33A 1nhzA-3ripA:
undetectable		 1nhzA-3ripA:
18.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		7 ASN A  33
GLY A  36
GLN A  39
MET A  73
LEU A  77
ARG A  80
MET A 115
 1CA  A 249 (-3.0A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
 0.92A 1nhzA-3ry9A:
29.8		 1nhzA-3ry9A:
71.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ry9 ANCESTRAL
GLUCOCORTICOID
RECEPTOR 1

(synthetic
construct) 		PF00104
(Hormone_recep) 		8 LEU A  32
GLY A  36
GLN A  39
MET A  73
LEU A  77
ARG A  80
MET A 115
LEU A 201
 1CA  A 249 (-3.9A)
1CA  A 249 ( 4.0A)
1CA  A 249 (-3.0A)
1CA  A 249 (-3.9A)
1CA  A 249 ( 4.1A)
1CA  A 249 (-3.5A)
1CA  A 249 (-3.6A)
1CA  A 249 ( 4.2A)
 0.64A 1nhzA-3ry9A:
29.8		 1nhzA-3ry9A:
71.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY

(Syntrophus
aciditrophicus) 		PF00440
(TetR_N) 		5 ASN A 133
MET A  86
LEU A  90
ARG A  93
LEU A 157
 None
 1.30A 1nhzA-3s5rA:
undetectable		 1nhzA-3s5rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s63 SAPOSIN-LIKE PROTEIN

(Necator
americanus) 		no annotation 5 LEU A  14
VAL A  32
LEU A  52
MET A  78
LEU A  59
 None
 1.39A 1nhzA-3s63A:
undetectable		 1nhzA-3s63A:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01554
(MatE) 		5 LEU A 247
GLY A 246
VAL A  75
LEU A  69
LEU A 254
 None
 1.01A 1nhzA-3wbnA:
undetectable		 1nhzA-3wbnA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zhp CALCIUM-BINDING
PROTEIN 39-LIKE

(Homo sapiens) 		PF08569
(Mo25) 		5 MET A 258
LEU A 262
ASN A 260
LEU A 305
LEU A 294
 None
 1.40A 1nhzA-3zhpA:
undetectable		 1nhzA-3zhpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4am3 POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Caulobacter
vibrioides) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		5 LEU A 202
GLY A 204
VAL A 154
LEU A 507
MET A 509
 None
 1.18A 1nhzA-4am3A:
undetectable		 1nhzA-4am3A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmf AMINOTRANSFERASE

([Nectria]
haematococca) 		PF01063
(Aminotran_4) 		5 LEU A  78
ASN A  76
LEU A 138
MET A 140
LEU A 100
 None
 1.28A 1nhzA-4cmfA:
undetectable		 1nhzA-4cmfA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvw LIMIT DEXTRINASE
INHIBITOR

(Hordeum vulgare) 		PF00234
(Tryp_alpha_amyl) 		5 ASN C  18
GLY C  79
VAL C  69
ARG C  89
LEU C  62
 None
 1.19A 1nhzA-4cvwC:
undetectable		 1nhzA-4cvwC:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 5 MET A 245
ASN A 648
GLY A 644
GLN A 359
VAL A 360
 None
 1.36A 1nhzA-4fyeA:
undetectable		 1nhzA-4fyeA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvz 26 KDA PERIPLASMIC
IMMUNOGENIC PROTEIN

(Brucella
abortus) 		PF04402
(SIMPL) 		5 LEU A  59
ASN A  58
MET A  79
MET A  86
LEU A  96
 None
 1.42A 1nhzA-4hvzA:
undetectable		 1nhzA-4hvzA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k1p NHEA

(Bacillus cereus) 		PF05791
(Bacillus_HBL) 		5 LEU A 233
ASN A 207
GLY A 231
GLN A 256
LEU A  34
 None
 1.43A 1nhzA-4k1pA:
undetectable		 1nhzA-4k1pA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbf HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 272
GLY A 270
VAL A 297
GLN A 266
LEU A 292
 None
 1.36A 1nhzA-4kbfA:
undetectable		 1nhzA-4kbfA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0o CYSTATHIONINE
GAMMA-SYNTHASE

(Helicobacter
pylori) 		no annotation 5 GLY H 193
VAL H 203
LEU H 245
ARG H 248
LEU H  58
 None
 1.40A 1nhzA-4l0oH:
undetectable		 1nhzA-4l0oH:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		5 GLY A 352
LEU A 346
GLN A 362
MET A 366
LEU A 398
 None
 1.42A 1nhzA-4lggA:
undetectable		 1nhzA-4lggA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lle PROBABLE
TWO-COMPONENT SENSOR

(Pseudomonas
aeruginosa) 		PF16767
(KinB_sensor) 		5 LEU A  60
GLY A  64
VAL A  68
GLN A 150
LEU A 146
 None
GOL  A 201 (-3.7A)
None
None
None
 0.99A 1nhzA-4lleA:
undetectable		 1nhzA-4lleA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m88 EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Verminephrobacter
eiseniae) 		PF13458
(Peripla_BP_6) 		5 GLY A 248
VAL A 250
LEU A 136
MET A 138
LEU A 141
 None
 1.18A 1nhzA-4m88A:
undetectable		 1nhzA-4m88A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mco TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		5 LEU A 108
ASN A 109
GLY A 111
LEU A 146
MET A 247
 None
 1.32A 1nhzA-4mcoA:
undetectable		 1nhzA-4mcoA:
22.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 563
ASN A 564
GLY A 567
GLN A 570
VAL A 571
MET A 604
ARG A 611
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.0A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 (-4.2A)
 1.01A 1nhzA-4p6wA:
31.4		 1nhzA-4p6wA:
96.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p6w GLUCOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 LEU A 563
GLY A 567
GLN A 570
VAL A 571
MET A 604
LEU A 608
ARG A 611
MET A 646
LEU A 732
 MOF  A 801 (-3.9A)
MOF  A 801 (-3.4A)
MOF  A 801 (-2.9A)
None
None
MOF  A 801 ( 4.6A)
MOF  A 801 (-4.2A)
MOF  A 801 (-4.4A)
MOF  A 801 ( 4.2A)
 0.61A 1nhzA-4p6wA:
31.4		 1nhzA-4p6wA:
96.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rni MOTILITY REGULATOR

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 LEU A  75
GLY A  71
VAL A  67
LEU A 109
LEU A 131
 None
 0.99A 1nhzA-4rniA:
undetectable		 1nhzA-4rniA:
24.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 769
GLN A 776
LEU A 814
ARG A 817
MET A 852
LEU A 938
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
CV7  A1987 ( 3.7A)
CV7  A1987 ( 3.9A)
 0.61A 1nhzA-4udbA:
28.7		 1nhzA-4udbA:
51.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmh HEME OXYGENASE 2

(Homo sapiens) 		PF01126
(Heme_oxygenase) 		5 MET A 158
LEU A 161
GLY A 164
GLN A 165
VAL A 166
 None
 1.07A 1nhzA-4wmhA:
undetectable		 1nhzA-4wmhA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 LEU A 162
VAL A 359
LEU A 200
MET A 206
LEU A 153
 None
 1.41A 1nhzA-4xaiA:
12.3		 1nhzA-4xaiA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z61 PHYTOSULFOKINE
RECEPTOR 1

(Daucus carota) 		PF00560
(LRR_1)
PF13855
(LRR_8) 		5 LEU A 331
ASN A 356
LEU A 298
MET A 294
LEU A 314
 None
 1.40A 1nhzA-4z61A:
undetectable		 1nhzA-4z61A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		5 ASN A 573
GLY A 575
MET A 614
LEU A 615
MET A 617
 None
None
None
ACO  A 901 (-4.6A)
None
 1.29A 1nhzA-4zm6A:
undetectable		 1nhzA-4zm6A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb2 PROTEIN SEY1

(Candida
albicans) 		PF05879
(RHD3) 		5 ASN A 267
GLY A 270
VAL A 274
LEU A 200
LEU A  75
 None
 1.21A 1nhzA-5cb2A:
undetectable		 1nhzA-5cb2A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6c URIC ACID-XANTHINE
PERMEASE

(Aspergillus
nidulans) 		PF00860
(Xan_ur_permease) 		5 MET A 400
GLY A 152
VAL A 150
MET A  90
LEU A 120
 None
 1.35A 1nhzA-5i6cA:
undetectable		 1nhzA-5i6cA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iry DESMOCOLLIN-1

(Homo sapiens) 		PF00028
(Cadherin) 		5 LEU A   9
LEU A  50
ARG A  64
GLN A  22
LEU A  76
 None
 1.44A 1nhzA-5iryA:
undetectable		 1nhzA-5iryA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jij ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Mycolicibacterium
thermoresistibile) 		PF00982
(Glyco_transf_20) 		5 VAL A 395
LEU A 368
ARG A 365
GLN A 318
LEU A 282
 None
EDO  A 507 (-4.7A)
None
None
None
 1.33A 1nhzA-5jijA:
undetectable		 1nhzA-5jijA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 LEU A 172
VAL A 369
LEU A 210
MET A 216
LEU A 163
 None
 1.43A 1nhzA-5jqeA:
undetectable		 1nhzA-5jqeA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldn HEXON PROTEIN,HEXON
CAPSID

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		5 MET A 336
ASN A 583
LEU A 614
GLN A 563
LEU A 347
 None
 1.41A 1nhzA-5ldnA:
undetectable		 1nhzA-5ldnA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lh9 OMEGA TRANSAMINASE

(Pseudomonas sp.) 		PF00202
(Aminotran_3) 		5 LEU A 144
ASN A 146
GLY A 147
LEU A 219
GLN A 203
 None
 1.34A 1nhzA-5lh9A:
undetectable		 1nhzA-5lh9A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1t MUCR
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		5 GLY A 501
GLN A 533
VAL A 498
LEU A 488
LEU A 441
 None
C2E  A 701 (-3.4A)
None
C2E  A 701 (-4.6A)
None
 1.38A 1nhzA-5m1tA:
undetectable		 1nhzA-5m1tA:
22.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 ASN A 770
GLN A 776
LEU A 814
ARG A 817
MET A 852
 ECV  A1101 (-3.1A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
 1.34A 1nhzA-5mwpA:
28.8		 1nhzA-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 GLN A 776
LEU A 814
ARG A 817
MET A 852
LEU A 938
 ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 (-3.7A)
ECV  A1101 ( 4.3A)
 1.30A 1nhzA-5mwpA:
28.8		 1nhzA-5mwpA:
41.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
GLN A 776
LEU A 814
ARG A 817
LEU A 938
 ECV  A1101 (-4.7A)
ECV  A1101 (-2.9A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
ECV  A1101 ( 4.3A)
 0.51A 1nhzA-5mwpA:
28.8		 1nhzA-5mwpA:
41.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 LEU A 267
GLY A 471
VAL A 438
LEU A 260
LEU A 245
 None
 1.44A 1nhzA-5oltA:
undetectable		 1nhzA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opq 3,6-ANHYDRO-D-GALACT
OSIDASE

(Zobellia
galactanivorans) 		no annotation 5 GLY A 221
GLN A 179
LEU A 541
GLN A 249
LEU A 275
 None
 1.25A 1nhzA-5opqA:
undetectable		 1nhzA-5opqA:
11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 7 ASN A 560
GLY A 563
GLN A 566
VAL A 567
MET A 600
LEU A 604
ARG A 607
 486  A 801 (-4.2A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
None
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
 0.78A 1nhzA-5uc1A:
26.9		 1nhzA-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 8 LEU A 559
GLY A 563
GLN A 566
VAL A 567
MET A 600
LEU A 604
ARG A 607
GLN A 638
 486  A 801 (-4.7A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
None
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 (-4.6A)
 0.68A 1nhzA-5uc1A:
26.9		 1nhzA-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 8 LEU A 559
GLY A 563
GLN A 566
VAL A 567
MET A 600
LEU A 604
ARG A 607
MET A 642
 486  A 801 (-4.7A)
486  A 801 (-3.7A)
486  A 801 (-2.8A)
None
None
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
486  A 801 ( 3.8A)
 0.38A 1nhzA-5uc1A:
26.9		 1nhzA-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uc1 GLUCOCORTICOID
RECEPTOR

(Heterocephalus
glaber) 		no annotation 5 VAL A 567
MET A 600
LEU A 604
ARG A 607
GLN A 641
 None
None
486  A 801 ( 3.8A)
486  A 801 (-3.5A)
CPS  A 803 (-3.5A)
 1.39A 1nhzA-5uc1A:
26.9		 1nhzA-5uc1A:
75.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 LEU A  32
ASN A  33
GLY A  36
GLN A  39
VAL A  40
ARG A  80
 1TA  A 301 (-3.5A)
1TA  A 301 (-3.0A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 (-3.5A)
 0.93A 1nhzA-5ufsA:
31.9		 1nhzA-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		9 LEU A  32
GLY A  36
GLN A  39
VAL A  40
MET A  73
LEU A  77
ARG A  80
MET A 115
LEU A 201
 1TA  A 301 (-3.5A)
1TA  A 301 (-2.9A)
1TA  A 301 (-3.0A)
None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
1TA  A 301 ( 2.8A)
1TA  A 301 ( 3.8A)
 0.58A 1nhzA-5ufsA:
31.9		 1nhzA-5ufsA:
71.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ufs ANCESTRAL
GLUCOCORTICOID
RECEPTOR2

(unidentified) 		PF00104
(Hormone_recep) 		6 VAL A  40
MET A  73
LEU A  77
ARG A  80
GLN A 111
MET A 115
 None
1TA  A 301 (-4.2A)
1TA  A 301 ( 3.4A)
1TA  A 301 (-3.5A)
None
1TA  A 301 ( 2.8A)
 1.31A 1nhzA-5ufsA:
31.9		 1nhzA-5ufsA:
71.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc7 VCP-LIKE ATPASE

(Thermoplasma
acidophilum) 		PF00004
(AAA) 		5 ASN A 685
GLY A 683
MET A 652
LEU A 654
LEU A 645
 None
 1.32A 1nhzA-5vc7A:
undetectable		 1nhzA-5vc7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8m VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 29

(Chaetomium
thermophilum) 		no annotation 5 LEU A  11
ASN A  10
GLY A  40
VAL A  61
LEU A   6
 None
 0.96A 1nhzA-5w8mA:
undetectable		 1nhzA-5w8mA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu ENVELOPE
GLYCOPROTEIN GP160

(Human
immunodeficiency
virus 1) 		no annotation 5 LEU G 454
ASN G 283
GLY G 471
GLN G 258
VAL G 371
 None
 0.89A 1nhzA-5wduG:
undetectable		 1nhzA-5wduG:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x2v L-METHIONINE
GAMMA-LYASE

(Pseudomonas
putida) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 332
ASN A 330
LEU A 376
GLN A 392
LEU A 394
 None
 1.44A 1nhzA-5x2vA:
undetectable		 1nhzA-5x2vA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VL-SARAH(S37C)CHIMER
A

(Homo sapiens;
Mus musculus) 		PF07686
(V-set)
PF11629
(Mst1_SARAH) 		5 ASN B  34
GLY B  46
VAL B  58
GLN B   6
LEU B  21
 None
 1.41A 1nhzA-5xctB:
undetectable		 1nhzA-5xctB:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y2a INSECT GROUP II
CHITINASE

(Ostrinia
furnacalis) 		no annotation 5 MET A2390
LEU A2392
GLY A2394
VAL A2060
LEU A2247
 None
 1.02A 1nhzA-5y2aA:
undetectable		 1nhzA-5y2aA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6de8 BIFUNCTIONAL PROTEIN
FOLD

(Campylobacter
jejuni) 		no annotation 5 LEU A 128
ASN A 129
GLY A 131
MET A 145
LEU A 177
 None
 1.29A 1nhzA-6de8A:
undetectable		 1nhzA-6de8A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 GLY A 193
VAL A 191
LEU A 159
ARG A 376
LEU A 144
 None
None
None
None
FAD  A 600 (-3.7A)
 1.36A 1nhzA-6fydA:
undetectable		 1nhzA-6fydA:
13.21