SIMILAR PATTERNS OF AMINO ACIDS FOR 1NH8_A_HISA289_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a1s ORNITHINE
CARBAMOYLTRANSFERASE

(Pyrococcus
furiosus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 141
LEU A  24
ALA A 173
LEU A 170
 None
 1.03A 1nh8A-1a1sA:
0.6		 1nh8A-1a1sA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drk D-RIBOSE-BINDING
PROTEIN

(Escherichia
coli) 		PF13407
(Peripla_BP_4) 		4 ASP A 249
LEU A  62
ALA A  27
LEU A  30
 None
 1.10A 1nh8A-1drkA:
1.5		 1nh8A-1drkA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT BETA

(Desulfovibrio
gigas) 		PF13247
(Fer4_11) 		4 ASP B  88
ASP B  85
ALA B  84
LEU B 110
 None
 1.15A 1nh8A-1h0hB:
0.0		 1nh8A-1h0hB:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6o TATD-RELATED
DEOXYRIBONUCLEASE

(Thermotoga
maritima) 		PF01026
(TatD_DNase) 		4 ASP A   2
LEU A 220
ALA A   5
LEU A   7
 None
 1.10A 1nh8A-1j6oA:
0.0		 1nh8A-1j6oA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		4 ASP A 225
LEU A  32
ALA A 229
LEU A 147
 None
 1.16A 1nh8A-1jdzA:
0.0		 1nh8A-1jdzA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kt1 FK506-BINDING
PROTEIN FKBP51

(Saimiri
boliviensis) 		PF00254
(FKBP_C)
PF00515
(TPR_1)
PF13181
(TPR_8) 		4 ASP A 203
LEU A 219
ALA A 205
LEU A 206
 None
 1.12A 1nh8A-1kt1A:
0.1		 1nh8A-1kt1A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 142
LEU A  23
ALA A 176
LEU A 173
 None
 1.04A 1nh8A-1ml4A:
1.6		 1nh8A-1ml4A:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ASP A  30
LEU A  39
ALA A  68
LEU A  27
 None
 1.14A 1nh8A-1nl3A:
0.0		 1nh8A-1nl3A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  43
LEU A   6
ALA A 307
LEU A  39
 None
 1.13A 1nh8A-1o8cA:
0.0		 1nh8A-1o8cA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 XYLANASE INHIBITOR
PROTEIN I
ENDO-1,4-BETA-XYLANA
SE

(Triticum
aestivum;
Aspergillus
nidulans) 		PF00704
(Glyco_hydro_18)
PF00331
(Glyco_hydro_10) 		4 ASP B 238
ASP B 278
LEU A 269
ALA B 240
 None
None
EDO  B1007 (-4.5A)
None
 1.08A 1nh8A-1ta3B:
undetectable		 1nh8A-1ta3B:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8d HYPOTHETICAL PROTEIN
(TT1679)

(Thermus
thermophilus) 		PF04260
(DUF436) 		4 ASP A 172
LEU A  96
ALA A 203
LEU A 202
 None
 1.04A 1nh8A-1v8dA:
undetectable		 1nh8A-1v8dA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 142
LEU A  25
ALA A 175
LEU A 172
 None
 0.96A 1nh8A-1vlvA:
1.1		 1nh8A-1vlvA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE BETA
SUBUNIT

(Acetoanaerobium
sticklandii) 		PF02310
(B12-binding)
PF16554
(OAM_dimer) 		4 ASP B 182
LEU B 185
ALA B 252
LEU B 256
 None
B12  B 800 (-3.6A)
None
None
 1.05A 1nh8A-1xrsB:
undetectable		 1nh8A-1xrsB:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8c S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Clostridium
acetobutylicum) 		PF13649
(Methyltransf_25) 		4 ASP A  67
LEU A  97
ALA A  90
LEU A  73
 None
 1.14A 1nh8A-1y8cA:
undetectable		 1nh8A-1y8cA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yis ADENYLOSUCCINATE
LYASE

(Caenorhabditis
elegans) 		PF00206
(Lyase_1) 		4 ASP A 136
LEU A 467
ALA A 139
LEU A 143
 None
 1.10A 1nh8A-1yisA:
undetectable		 1nh8A-1yisA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z00 DNA EXCISION REPAIR
PROTEIN ERCC-1

(Homo sapiens) 		PF14520
(HHH_5) 		4 ASP A 270
LEU A 273
ALA A 266
LEU A 263
 None
 1.17A 1nh8A-1z00A:
undetectable		 1nh8A-1z00A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 141
LEU A  24
ALA A 175
LEU A 172
 None
 0.82A 1nh8A-2atcA:
undetectable		 1nh8A-2atcA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE

(Homo sapiens) 		PF01596
(Methyltransf_3) 		4 ASP A 185
LEU A 120
ALA A 209
LEU A 211
 SAM  A 501 (-3.4A)
None
None
None
 1.09A 1nh8A-2avdA:
undetectable		 1nh8A-2avdA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkw ALANINE-GLYOXYLATE
AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00266
(Aminotran_5) 		4 ASP A 175
LEU A 156
ALA A 195
LEU A 196
 PLP  A1201 (-3.0A)
None
None
None
 1.11A 1nh8A-2bkwA:
undetectable		 1nh8A-2bkwA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfo GLUTAMYL-TRNA
SYNTHETASE

(Synechococcus
elongatus) 		PF00749
(tRNA-synt_1c) 		4 ASP A 470
LEU A 457
ALA A 447
LEU A 474
 None
 1.05A 1nh8A-2cfoA:
0.6		 1nh8A-2cfoA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		4 ASP A 388
LEU A 353
ALA A 372
LEU A 375
 None
 1.07A 1nh8A-2dhrA:
undetectable		 1nh8A-2dhrA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ASP E1274
ASP E1271
LEU E1280
ALA E1272
 None
 1.03A 1nh8A-2fo1E:
undetectable		 1nh8A-2fo1E:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ioy PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caldanaerobacter
subterraneus) 		PF13407
(Peripla_BP_4) 		4 ASP A 250
LEU A  62
ALA A  27
LEU A  30
 None
 1.11A 1nh8A-2ioyA:
2.4		 1nh8A-2ioyA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 ASP A  87
LEU A  63
ALA A  91
LEU A  95
 None
 1.02A 1nh8A-2iyfA:
undetectable		 1nh8A-2iyfA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6h GLUCOSAMINE-FRUCTOSE
-6-PHOSPHATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF01380
(SIS)
PF13522
(GATase_6) 		4 ASP A 210
LEU A 146
ALA A 172
LEU A 206
 None
 1.12A 1nh8A-2j6hA:
2.4		 1nh8A-2j6hA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsd MATRIX
METALLOPROTEINASE-20

(Homo sapiens) 		PF00413
(Peptidase_M10) 		4 ASP A 262
LEU A 269
ALA A 152
LEU A 258
 None
 1.05A 1nh8A-2jsdA:
undetectable		 1nh8A-2jsdA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus) 		PF01115
(F_actin_cap_B) 		4 ASP B 338
LEU B 325
ALA B 309
LEU B 306
 None
 1.15A 1nh8A-2kxpB:
undetectable		 1nh8A-2kxpB:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lnl C-X-C CHEMOKINE
RECEPTOR TYPE 1

(Homo sapiens) 		PF00001
(7tm_1) 		4 ASP A  85
LEU A  54
ALA A  84
LEU A 116
 None
 1.10A 1nh8A-2lnlA:
undetectable		 1nh8A-2lnlA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		4 ASP A 126
LEU A 176
ALA A 172
LEU A 171
 None
 0.96A 1nh8A-2ob1A:
undetectable		 1nh8A-2ob1A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okx RHAMNOSIDASE B

(Bacillus sp.
GL1) 		PF05592
(Bac_rhamnosid)
PF08531
(Bac_rhamnosid_N)
PF17389
(Bac_rhamnosid6H)
PF17390
(Bac_rhamnosid_C) 		4 ASP A 162
LEU A 159
ALA A 164
LEU A 165
 None
 1.10A 1nh8A-2okxA:
undetectable		 1nh8A-2okxA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 138
LEU A  19
ALA A 172
LEU A 169
 None
 1.01A 1nh8A-2rgwA:
undetectable		 1nh8A-2rgwA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rif CONSERVED PROTEIN
WITH 2 CBS DOMAINS

(Pyrobaculum
aerophilum) 		PF00571
(CBS) 		4 ASP A 118
LEU A 129
ALA A  89
LEU A 114
 AMP  A 201 (-2.4A)
None
None
None
 1.13A 1nh8A-2rifA:
undetectable		 1nh8A-2rifA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 ASP A 162
LEU A 104
ALA A 132
LEU A 135
 None
 1.05A 1nh8A-2vn7A:
undetectable		 1nh8A-2vn7A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 ASP A1251
ASP A1276
LEU A1282
LEU A1321
 None
 1.14A 1nh8A-2vz9A:
undetectable		 1nh8A-2vz9A:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyb HYPOTHETICAL PROTEIN
TTHA1606

(Thermus
thermophilus) 		PF01784
(NIF3) 		4 ASP A 101
ASP A 125
LEU A 176
LEU A  98
 None
 1.14A 1nh8A-2yybA:
undetectable		 1nh8A-2yybA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 ASP A 156
LEU A 188
ALA A 174
LEU A 170
 None
 1.16A 1nh8A-2z4gA:
undetectable		 1nh8A-2z4gA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zcx TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ASP A  48
LEU A  60
ALA A  32
LEU A  35
 None
 1.11A 1nh8A-2zcxA:
undetectable		 1nh8A-2zcxA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0p TRNA-DIHYDROURIDINE
SYNTHASE

(Thermus
thermophilus) 		PF01207
(Dus) 		4 ASP A  39
LEU A  51
ALA A  76
LEU A  72
 None
 1.01A 1nh8A-3b0pA:
undetectable		 1nh8A-3b0pA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 136
LEU A 155
ALA A 161
LEU A 160
 None
 0.97A 1nh8A-3bhhA:
undetectable		 1nh8A-3bhhA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chi P-AMINOBENZOATE
N-OXYGENASE

(Streptomyces
thioluteus) 		PF11583
(AurF) 		4 ASP A 185
LEU A 171
ALA A 108
LEU A 111
 None
 1.08A 1nh8A-3chiA:
undetectable		 1nh8A-3chiA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckn PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
avium) 		PF00535
(Glycos_transf_2) 		4 ASP A 161
ASP A 251
ALA A  27
LEU A  26
 None
 1.13A 1nh8A-3cknA:
undetectable		 1nh8A-3cknA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crn RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN, CHEY-LIKE

(Methanospirillum
hungatei) 		PF00072
(Response_reg) 		4 ASP A   8
LEU A  63
ALA A  31
LEU A  14
 PHD  A  52 ( 3.6A)
None
None
None
 1.12A 1nh8A-3crnA:
undetectable		 1nh8A-3crnA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		4 ASP A  96
LEU A  90
ALA A  52
LEU A  48
 None
 1.06A 1nh8A-3f6tA:
undetectable		 1nh8A-3f6tA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdb AAHIV

(Deinagkistrodon
acutus) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASP A 319
ASP A 206
LEU A 288
ALA A 208
 None
 1.09A 1nh8A-3hdbA:
undetectable		 1nh8A-3hdbA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		4 ASP B 266
LEU B 233
ALA B 268
LEU B 269
 None
 1.17A 1nh8A-3hkzB:
undetectable		 1nh8A-3hkzB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A 338
LEU A  18
ALA A 363
LEU A 340
 None
 1.13A 1nh8A-3i6eA:
undetectable		 1nh8A-3i6eA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ios DISULFIDE BOND
FORMING PROTEIN
(DSBF)

(Mycobacterium
tuberculosis) 		PF00578
(AhpC-TSA) 		4 ASP A 153
LEU A  50
ALA A  72
LEU A 177
 None
 0.90A 1nh8A-3iosA:
undetectable		 1nh8A-3iosA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j08 COPPER-EXPORTING
P-TYPE ATPASE A

(Archaeoglobus
fulgidus) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		4 ASP A 438
LEU A 449
ALA A 531
LEU A 524
 None
 1.14A 1nh8A-3j08A:
undetectable		 1nh8A-3j08A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 102
LEU A  83
ALA A  57
LEU A  88
 None
 1.01A 1nh8A-3k1dA:
undetectable		 1nh8A-3k1dA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1j ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF05362
(Lon_C)
PF13654
(AAA_32) 		4 ASP A  91
LEU A 184
ALA A 111
LEU A  89
 None
 1.05A 1nh8A-3k1jA:
undetectable		 1nh8A-3k1jA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8v FLAGELLIN HOMOLOG

(Sphingomonas
sp. A1) 		PF00669
(Flagellin_N)
PF00700
(Flagellin_C)
PF07196
(Flagellin_IN) 		4 ASP A 301
LEU A 285
ALA A 303
LEU A 304
 None
 1.14A 1nh8A-3k8vA:
undetectable		 1nh8A-3k8vA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l91 ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ
SUBUNIT BETA

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 ASP B 386
LEU B 476
ALA B 407
LEU B 280
 None
 1.13A 1nh8A-3l91B:
undetectable		 1nh8A-3l91B:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxm ASPARTATE
CARBAMOYLTRANSFERASE

(Yersinia pestis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 142
LEU A  25
ALA A 176
LEU A 173
 None
 1.00A 1nh8A-3lxmA:
undetectable		 1nh8A-3lxmA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0z ADENYLATE CYCLASE 2

(Yersinia pestis) 		PF01928
(CYTH) 		4 ASP A 126
ASP A 133
LEU A  20
LEU A 128
 None
 1.10A 1nh8A-3n0zA:
undetectable		 1nh8A-3n0zA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nx4 PUTATIVE
OXIDOREDUCTASE

(Salmonella
enterica) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A  43
LEU A   6
ALA A 307
LEU A  39
 None
 1.13A 1nh8A-3nx4A:
undetectable		 1nh8A-3nx4A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 ASP A 203
LEU A 219
ALA A 205
LEU A 206
 None
 1.11A 1nh8A-3o5dA:
undetectable		 1nh8A-3o5dA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Salmonella
enterica) 		PF00290
(Trp_syntA) 		4 ASP A 130
LEU A 127
ALA A  59
LEU A  58
 None
F9F  A   1 (-4.7A)
F9F  A   1 (-3.5A)
None
 1.11A 1nh8A-3pr2A:
undetectable		 1nh8A-3pr2A:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pvl MYOSIN VIIA ISOFORM
1

(Mus musculus) 		PF00784
(MyTH4) 		4 ASP A1034
LEU A1087
ALA A1038
LEU A1167
 GOL  A   5 (-4.0A)
None
None
None
 1.12A 1nh8A-3pvlA:
undetectable		 1nh8A-3pvlA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk7 TRANSCRIPTIONAL
REGULATORS

(Yersinia pestis) 		PF00532
(Peripla_BP_1) 		4 ASP A 109
LEU A 269
ALA A 112
LEU A 116
 None
 1.15A 1nh8A-3qk7A:
2.6		 1nh8A-3qk7A:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rob UNCHARACTERIZED
CONSERVED PROTEIN

(Planctopirus
limnophila) 		PF14534
(DUF4440) 		4 ASP A 129
LEU A 126
ALA A 112
LEU A  93
 GOL  A 137 (-2.8A)
None
GOL  A 137 ( 3.7A)
None
 1.13A 1nh8A-3robA:
undetectable		 1nh8A-3robA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1v PROBABLE
TRANSALDOLASE

(Thermoplasma
acidophilum) 		PF00923
(TAL_FSA) 		4 ASP A   6
LEU A  31
ALA A 166
LEU A 164
 F6R  A 226 (-3.0A)
None
F6R  A 226 (-3.3A)
F6R  A 226 ( 4.4A)
 1.14A 1nh8A-3s1vA:
undetectable		 1nh8A-3s1vA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4g NAMN:DMB
PHOSPHORIBOSYLTRANSF
ERASE

(Pyrococcus
horikoshii) 		no annotation 4 ASP A 319
LEU A 279
ALA A  72
LEU A  75
 None
 1.02A 1nh8A-3u4gA:
undetectable		 1nh8A-3u4gA:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcn MANNONATE
DEHYDRATASE

(Caulobacter
vibrioides) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A  34
LEU A  48
ALA A  88
LEU A 288
 None
 0.97A 1nh8A-3vcnA:
undetectable		 1nh8A-3vcnA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4apw ALP12

(Clostridium
tetani) 		no annotation 4 ASP A 219
LEU A 225
ALA A 216
LEU A 217
 None
 1.06A 1nh8A-4apwA:
undetectable		 1nh8A-4apwA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ASP A 179
ASP A 173
LEU A 166
ALA A 174
 None
 1.10A 1nh8A-4b7gA:
undetectable		 1nh8A-4b7gA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		4 ASP A 320
ASP A 209
LEU A 290
ALA A 211
 None
 1.16A 1nh8A-4dd8A:
undetectable		 1nh8A-4dd8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 ASP A 241
LEU A  44
ALA A 260
LEU A 259
 None
 1.14A 1nh8A-4e8dA:
undetectable		 1nh8A-4e8dA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 177
LEU A 194
ALA A 200
LEU A 199
 None
 1.04A 1nh8A-4f99A:
undetectable		 1nh8A-4f99A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fi4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Caulobacter sp.
K31) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ASP A  34
LEU A  48
ALA A  88
LEU A 288
 None
 0.97A 1nh8A-4fi4A:
undetectable		 1nh8A-4fi4A:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbs PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF14064
(HmuY) 		4 ASP A 216
LEU A  70
ALA A 197
LEU A 115
 None
None
None
SO4  A 301 (-3.9A)
 1.13A 1nh8A-4gbsA:
undetectable		 1nh8A-4gbsA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqw CBS
DOMAIN-CONTAINING
PROTEIN CBSX1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00571
(CBS) 		4 ASP A 126
LEU A 174
ALA A  99
LEU A 103
 None
 1.07A 1nh8A-4gqwA:
undetectable		 1nh8A-4gqwA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 ASP A 283
LEU A 523
ALA A 263
LEU A 279
 None
 1.09A 1nh8A-4ia5A:
undetectable		 1nh8A-4ia5A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nj5 PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH9

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		4 ASP A 582
LEU A 414
ALA A 526
LEU A 527
 None
 1.08A 1nh8A-4nj5A:
undetectable		 1nh8A-4nj5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh7 ORNITHINE
CARBAMOYLTRANSFERASE

(Brucella
melitensis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ASP A 142
LEU A  25
ALA A 174
LEU A 171
 None
 1.06A 1nh8A-4oh7A:
undetectable		 1nh8A-4oh7A:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q20 SENSOR PROTEIN DIVL

(Caulobacter
vibrioides) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 ASP A 599
LEU A 610
ALA A 729
LEU A 726
 None
 1.16A 1nh8A-4q20A:
undetectable		 1nh8A-4q20A:
27.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvs PROBABLE QUINONE
REDUCTASE QOR
(NADPH:QUINONE
REDUCTASE)
(ZETA-CRYSTALLIN
HOMOLOG PROTEIN)

(Mycobacterium
tuberculosis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ASP A 219
LEU A 159
ALA A 240
LEU A 241
 None
 1.14A 1nh8A-4rvsA:
undetectable		 1nh8A-4rvsA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2u RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE

(Escherichia
coli) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 ASP A 220
LEU A 152
ALA A 246
LEU A 229
 None
 1.01A 1nh8A-4s2uA:
undetectable		 1nh8A-4s2uA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zjp MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		4 ASP A 271
LEU A  85
ALA A  50
LEU A  53
 None
 1.09A 1nh8A-4zjpA:
undetectable		 1nh8A-4zjpA:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		4 ASP A  91
LEU A 184
ALA A 111
LEU A  89
 None
 1.05A 1nh8A-4zpxA:
undetectable		 1nh8A-4zpxA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		4 ASP B 192
LEU B 175
ALA B 165
LEU B 153
 None
 0.96A 1nh8A-5b47B:
1.5		 1nh8A-5b47B:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bok FERREDOXIN

(Diaphorobacter
sp. DS2) 		PF00355
(Rieske) 		4 ASP A  72
ASP A  86
ALA A  78
LEU A  79
 None
 0.97A 1nh8A-5bokA:
undetectable		 1nh8A-5bokA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsh PYRROLINE-5-CARBOXYL
ATE REDUCTASE

(Medicago
truncatula) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		4 ASP A  67
LEU A  91
ALA A  43
LEU A  62
 None
 1.02A 1nh8A-5bshA:
undetectable		 1nh8A-5bshA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cmc ML032222A IGLUR

(Mnemiopsis
leidyi) 		PF10613
(Lig_chan-Glu_bd) 		4 ASP A 187
LEU A 150
ALA A 115
LEU A 192
 None
 1.14A 1nh8A-5cmcA:
6.5		 1nh8A-5cmcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE

(Streptococcus
thermophilus) 		PF08331
(DUF1730)
PF13484
(Fer4_16) 		4 ASP A 305
LEU A 268
ALA A 299
LEU A 303
 None
 0.90A 1nh8A-5d6sA:
undetectable		 1nh8A-5d6sA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 ASP A 307
LEU A 299
ALA A 309
LEU A 310
 None
 1.11A 1nh8A-5dmhA:
1.9		 1nh8A-5dmhA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3g PUTATIVE ACYL-COA
BINDING PROTEIN
(ACBP)

(Oryza sativa) 		PF00887
(ACBP) 		4 ASP A  74
LEU A   3
ALA A  36
LEU A  32
 None
 1.06A 1nh8A-5h3gA:
undetectable		 1nh8A-5h3gA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3i PUTATIVE
ACYL-COA-BINDING
PROTEIN

(Oryza sativa) 		PF00887
(ACBP) 		4 ASP A  74
LEU A   3
ALA A  36
LEU A  32
 None
 1.11A 1nh8A-5h3iA:
undetectable		 1nh8A-5h3iA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iva LPS-ASSEMBLY PROTEIN
LPTD

(Pseudomonas
aeruginosa) 		PF04453
(OstA_C) 		4 ASP A 201
ASP A 257
LEU A 260
LEU A 196
 None
 0.87A 1nh8A-5ivaA:
undetectable		 1nh8A-5ivaA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j6c PUTATIVE REDUCTASE

(Clostridioides
difficile) 		PF00881
(Nitroreductase) 		4 ASP A  55
LEU A 140
ALA A  81
LEU A  80
 None
 0.99A 1nh8A-5j6cA:
undetectable		 1nh8A-5j6cA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		4 ASP A 208
ASP A 193
ALA A 200
LEU A 203
 None
 1.01A 1nh8A-5knnA:
undetectable		 1nh8A-5knnA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 4 ASP A  49
ASP A  53
ALA A  39
LEU A  45
 None
 1.16A 1nh8A-5m6gA:
undetectable		 1nh8A-5m6gA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mza ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		4 ASP A1096
LEU A1072
ALA A 830
LEU A 918
 None
 1.08A 1nh8A-5mzaA:
undetectable		 1nh8A-5mzaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 4 ASP A 174
LEU A 191
ALA A 211
LEU A 207
 None
 1.00A 1nh8A-5olcA:
undetectable		 1nh8A-5olcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf3 PUTATIVE MEMBRANE
PROTEIN

(Yersinia pestis) 		PF06711
(DUF1198) 		4 ASP A 113
LEU A 107
ALA A 115
LEU A 116
 None
 1.08A 1nh8A-5tf3A:
undetectable		 1nh8A-5tf3A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 ASP A 170
LEU A 260
ALA A 191
LEU A  64
 None
 1.07A 1nh8A-5ubkA:
undetectable		 1nh8A-5ubkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1

(Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1) 		4 ASP A 331
LEU A 395
ALA A 333
LEU A 334
 None
 1.02A 1nh8A-5uz9A:
undetectable		 1nh8A-5uz9A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6c HEMOLYSIN-RELATED
PROTEIN

(Vibrio cholerae) 		no annotation 4 ASP A 841
ASP A 882
ALA A 880
LEU A 843
 None
 0.93A 1nh8A-5v6cA:
undetectable		 1nh8A-5v6cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wft PELB

(Pseudomonas
aeruginosa) 		no annotation 4 ASP A 369
LEU A 377
ALA A 360
LEU A 341
 None
 1.13A 1nh8A-5wftA:
undetectable		 1nh8A-5wftA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhw GLUCOAMYLASE P

(Amorphotheca
resinae) 		no annotation 4 ASP A 191
LEU A 133
ALA A 161
LEU A 164
 None
 1.10A 1nh8A-6fhwA:
undetectable		 1nh8A-6fhwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy8 -

(-) 		no annotation 4 ASP A  96
LEU A 216
ALA A  98
LEU A  99
 None
 1.14A 1nh8A-6gy8A:
undetectable		 1nh8A-6gy8A:
undetectable