SIMILAR PATTERNS OF AMINO ACIDS FOR 1NG8_B_DVAB8_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1en4 MANGANESE SUPEROXIDE
DISMUTASE

(Escherichia
coli) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 GLY A  87
VAL A 192
TRP A 128
GLY A 165
 None
 1.33A 1ng8B-1en4A:
undetectable		 1ng8B-1en4A:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 124
VAL A 126
TRP A 131
GLY A 121
 None
 1.34A 1ng8B-1kolA:
undetectable		 1ng8B-1kolA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 124
VAL A 126
TRP A 131
GLY A 129
 None
 1.35A 1ng8B-1kolA:
undetectable		 1ng8B-1kolA:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ltm 36 KDA SOLUBLE LYTIC
TRANSGLYCOSYLASE

(Escherichia
coli) 		PF13406
(SLT_2) 		4 GLY A 268
VAL A 266
TRP A 145
GLY A 149
 None
 0.99A 1ng8B-1ltmA:
undetectable		 1ng8B-1ltmA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 163
VAL A 165
TRP A 445
GLY A 444
 None
 1.45A 1ng8B-1r8wA:
undetectable		 1ng8B-1r8wA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7i SALICYLIC
ACID-BINDING PROTEIN
2

(Nicotiana
tabacum) 		PF12697
(Abhydrolase_6) 		4 GLY A  12
VAL A  10
TRP A  18
GLY A  17
 SAL  A 501 ( 3.9A)
None
None
None
 0.84A 1ng8B-1y7iA:
undetectable		 1ng8B-1y7iA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zyo SERINE PROTEASE

(Sesbania mosaic
virus) 		PF02122
(Peptidase_S39) 		4 GLY A 285
VAL A 182
TRP A 283
GLY A 282
 None
None
None
GOL  A 500 (-3.7A)
 1.39A 1ng8B-1zyoA:
undetectable		 1ng8B-1zyoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		4 GLY A 249
VAL A 247
TRP A 277
GLY A 276
 None
SNG  A1406 (-3.9A)
SNG  A1407 (-3.7A)
SNG  A1407 (-4.4A)
 0.81A 1ng8B-2bwmA:
undetectable		 1ng8B-2bwmA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1u DI-HAEM CYTOCHROME C
PEROXIDASE

(Paracoccus
pantotrophus) 		PF00034
(Cytochrom_C)
PF03150
(CCP_MauG) 		4 GLY A 121
VAL A 123
TRP A  87
GLY A 126
 None
HEC  A 401 (-4.6A)
None
None
 1.35A 1ng8B-2c1uA:
undetectable		 1ng8B-2c1uA:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		4 GLY A 588
VAL A 590
TRP A 584
GLY A 583
 None
 1.30A 1ng8B-2d5wA:
undetectable		 1ng8B-2d5wA:
3.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2s MATRIX PROTEIN

(Lagos bat
lyssavirus) 		PF04785
(Rhabdo_M2) 		4 GLY A  91
VAL A  93
TRP A 181
GLY A  98
 None
 1.15A 1ng8B-2w2sA:
undetectable		 1ng8B-2w2sA:
6.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf4 HYDROXYACYLGLUTATHIO
NE HYDROLASE

(Salmonella
enterica) 		PF00753
(Lactamase_B) 		4 GLY A 135
VAL A 137
TRP A  86
GLY A  57
 None
 1.33A 1ng8B-2xf4A:
undetectable		 1ng8B-2xf4A:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xom ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE

(Thermotoga
maritima) 		no annotation 4 GLY A 155
VAL A 100
TRP A  68
GLY A 152
 None
None
GAL  A1166 ( 4.3A)
None
 1.42A 1ng8B-2xomA:
undetectable		 1ng8B-2xomA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al2 DNA TOPOISOMERASE
2-BINDING PROTEIN 1

(Homo sapiens) 		PF00533
(BRCT) 		4 GLY A1392
VAL A1390
TRP A1397
GLY A1396
 None
 1.21A 1ng8B-3al2A:
undetectable		 1ng8B-3al2A:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btp SINGLE-STRAND
DNA-BINDING PROTEIN

(Agrobacterium
fabrum) 		PF07229
(VirE2) 		4 GLY A 434
VAL A 431
TRP A 393
GLY A 390
 None
 1.17A 1ng8B-3btpA:
undetectable		 1ng8B-3btpA:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		4 GLY A 539
VAL A 518
TRP A 542
GLY A 547
 CA  A   1 (-4.3A)
CA  A   1 (-4.8A)
None
None
 1.33A 1ng8B-3edyA:
undetectable		 1ng8B-3edyA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edy TRIPEPTIDYL-PEPTIDAS
E 1

(Homo sapiens) 		PF09286
(Pro-kuma_activ) 		4 GLY A 541
VAL A 518
TRP A 542
GLY A 547
 CA  A   1 (-4.2A)
CA  A   1 (-4.8A)
None
None
 1.44A 1ng8B-3edyA:
undetectable		 1ng8B-3edyA:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fjy PROBABLE MUTT1
PROTEIN

(Bifidobacterium
adolescentis) 		PF00293
(NUDIX)
PF00300
(His_Phos_1) 		4 GLY A  14
VAL A  16
TRP A 122
GLY A  89
 None
 1.26A 1ng8B-3fjyA:
undetectable		 1ng8B-3fjyA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odt PROTEIN DOA1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		4 GLY A 238
VAL A 243
TRP A 265
GLY A 278
 None
 1.47A 1ng8B-3odtA:
undetectable		 1ng8B-3odtA:
3.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op7 AMINOTRANSFERASE
CLASS I AND II

(Streptococcus
suis) 		PF00155
(Aminotran_1_2) 		4 GLY A 167
VAL A 169
TRP A 139
GLY A 138
 None
EDO  A 403 (-4.2A)
None
EDO  A 403 (-3.5A)
 0.83A 1ng8B-3op7A:
undetectable		 1ng8B-3op7A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rht (GATASE1)-LIKE
PROTEIN

(Planctopirus
limnophila) 		PF07090
(GATase1_like) 		4 GLY A 149
VAL A 213
TRP A  85
GLY A  84
 None
None
GOL  A 260 (-4.1A)
GOL  A 260 (-3.5A)
 1.32A 1ng8B-3rhtA:
undetectable		 1ng8B-3rhtA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8q MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Hoeflea
phototrophica) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A  83
VAL A  31
TRP A 347
GLY A  29
 None
 1.13A 1ng8B-3t8qA:
undetectable		 1ng8B-3t8qA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		4 GLY A 310
VAL A 313
TRP A 239
GLY A 240
 None
 1.22A 1ng8B-3vv3A:
undetectable		 1ng8B-3vv3A:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdy BETA-1,3-1,4-GLUCANA
SE

(Paecilomyces
sp.
'thermophila') 		no annotation 4 GLY A  95
VAL A  93
TRP A  97
GLY A 119
 None
None
CBI  A 301 (-4.7A)
None
 1.35A 1ng8B-3wdyA:
undetectable		 1ng8B-3wdyA:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1d HYDANTOIN TRANSPORT
PROTEIN

(Microbacterium
liquefaciens) 		PF02133
(Transp_cyt_pur) 		4 GLY A 279
VAL A 276
TRP A 281
GLY A  50
 None
 0.96A 1ng8B-4d1dA:
undetectable		 1ng8B-4d1dA:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e8d GLYCOSYL HYDROLASE,
FAMILY 35

(Streptococcus
pneumoniae) 		PF01301
(Glyco_hydro_35) 		4 GLY A 451
VAL A 453
TRP A  99
GLY A 102
 None
 0.95A 1ng8B-4e8dA:
undetectable		 1ng8B-4e8dA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fin ETTA (YJJK) ABCF
FAMILY PROTEIN

(Escherichia
coli) 		PF00005
(ABC_tran)
PF12848
(ABC_tran_Xtn) 		4 GLY A  32
VAL A 212
TRP A 228
GLY A 227
 None
 1.30A 1ng8B-4finA:
undetectable		 1ng8B-4finA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2a HYPOTHETICAL PROTEIN

(Legionella
pneumophila) 		PF13308
(YARHG)
PF14415
(DUF4424) 		4 GLY A  37
VAL A 119
TRP A  71
GLY A 173
 None
 1.25A 1ng8B-4g2aA:
undetectable		 1ng8B-4g2aA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h08 PUTATIVE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF00657
(Lipase_GDSL) 		4 GLY A  59
VAL A  61
TRP A  34
GLY A  72
 None
 1.04A 1ng8B-4h08A:
undetectable		 1ng8B-4h08A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 125
VAL A 127
TRP A 132
GLY A 122
 None
 1.33A 1ng8B-4jlwA:
undetectable		 1ng8B-4jlwA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 125
VAL A 127
TRP A 132
GLY A 130
 None
 1.39A 1ng8B-4jlwA:
undetectable		 1ng8B-4jlwA:
3.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nmy ABC-TYPE TRANSPORT
SYSTEM,
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		PF09084
(NMT1) 		4 GLY A 112
VAL A 140
TRP A 114
GLY A 115
 None
None
VIB  A 401 (-3.7A)
None
 1.10A 1ng8B-4nmyA:
undetectable		 1ng8B-4nmyA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6q MSX2-INTERACTING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1) 		4 GLY A 379
VAL A 368
TRP A 411
GLY A 336
 None
 1.46A 1ng8B-4p6qA:
undetectable		 1ng8B-4p6qA:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 GLY A 390
VAL A 388
TRP A 281
GLY A 280
 None
 1.15A 1ng8B-4q2cA:
undetectable		 1ng8B-4q2cA:
1.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtq XAC2610 PROTEIN

(Xanthomonas
citri) 		no annotation 4 GLY A 168
VAL A 198
TRP A 163
GLY A 165
 None
 1.35A 1ng8B-4qtqA:
undetectable		 1ng8B-4qtqA:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g10 HDAH

(Pseudomonas
aeruginosa) 		PF00850
(Hist_deacetyl) 		4 GLY A 322
VAL A 318
TRP A 180
GLY A 267
 None
 1.15A 1ng8B-5g10A:
undetectable		 1ng8B-5g10A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxa ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		4 GLY A 192
VAL A 229
TRP A 136
GLY A 159
 None
 1.28A 1ng8B-5hxaA:
undetectable		 1ng8B-5hxaA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2g DIOL DEHYDRATASE

(Roseburia
inulinivorans) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 165
VAL A 167
TRP A 450
GLY A 449
 None
 1.42A 1ng8B-5i2gA:
undetectable		 1ng8B-5i2gA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it9 RIBOSOMAL PROTEIN
RACK1

(Kluyveromyces
lactis) 		PF01092
(Ribosomal_S6e) 		4 GLY g 311
VAL g 316
TRP g  20
GLY g  19
 None
 1.30A 1ng8B-5it9g:
undetectable		 1ng8B-5it9g:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwz CELLULOSE-BINDING
FAMILY II

(Streptomyces
sp. SirexAA-E) 		PF02012
(BNR) 		4 GLY A  71
VAL A  73
TRP A  69
GLY A 101
 None
 1.18A 1ng8B-5jwzA:
undetectable		 1ng8B-5jwzA:
1.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		4 GLY C 373
VAL C 309
TRP C 306
GLY C 281
 None
 1.43A 1ng8B-5k1cC:
undetectable		 1ng8B-5k1cC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		4 GLY C 373
VAL C 309
TRP C 381
GLY C 370
 None
 1.05A 1ng8B-5k1cC:
undetectable		 1ng8B-5k1cC:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxf PHOTORHABDUS
ASYMBIOTICA LECTIN
PHL

(Photorhabdus
asymbiotica) 		PF03984
(DUF346) 		4 GLY A 122
VAL A 124
TRP A 104
GLY A  98
 None
 1.27A 1ng8B-5mxfA:
undetectable		 1ng8B-5mxfA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 GLY A 184
VAL A 207
TRP A 199
GLY A 196
 None
 1.26A 1ng8B-6bz0A:
undetectable		 1ng8B-6bz0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1q SOLUBLE CYTOCHROME
B562, C5A
ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 4 GLY B 275
VAL B 262
TRP B 188
GLY B 192
 None
 1.21A 1ng8B-6c1qB:
undetectable		 1ng8B-6c1qB:
undetectable