SIMILAR PATTERNS OF AMINO ACIDS FOR 1NBI_A_SAMA293_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f7u ARGINYL-TRNA
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 ASP A  68
MET A  64
ASN A 115
TYR A 553
 None
 1.15A 1nbiA-1f7uA:
0.0		 1nbiA-1f7uA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus) 		PF02247
(Como_LCP) 		4 ARG 2 240
ASP 2 321
ASN 2 270
TYR 2 241
 None
 1.13A 1nbiA-1pgw2:
0.0		 1nbiA-1pgw2:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xsz GUANINE NUCLEOTIDE
EXCHANGE PROTEIN

(Legionella
pneumophila) 		PF01369
(Sec7) 		4 ARG A 293
ASP A  60
ASN A  69
TYR A 278
 None
 1.48A 1nbiA-1xszA:
0.6		 1nbiA-1xszA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nhi D7 PROTEIN

(Anopheles
stephensi) 		PF01395
(PBP_GOBP) 		4 ARG A 177
ASP A 214
ASN A 216
TYR A 179
 None
None
None
SO4  A 299 (-4.9A)
 1.47A 1nbiA-3nhiA:
0.0		 1nbiA-3nhiA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouh EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 383
MET A 299
ASN A 316
TYR A 303
 014  A 417 (-3.1A)
014  A 417 (-3.4A)
None
None
 1.40A 1nbiA-3ouhA:
0.0		 1nbiA-3ouhA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oui EGL NINE HOMOLOG 1

(Homo sapiens) 		PF13640
(2OG-FeII_Oxy_3) 		4 ARG A 383
MET A 299
ASN A 316
TYR A 303
 42Z  A 393 (-2.9A)
42Z  A 393 (-3.3A)
None
None
 1.30A 1nbiA-3ouiA:
0.0		 1nbiA-3ouiA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN

(Bacteroides
thetaiotaomicron) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP B 340
MET B 200
ASN B 196
TYR B 359
 None
 1.45A 1nbiA-5fq6B:
0.3		 1nbiA-5fq6B:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isx GRAMICIDIN S
SYNTHASE 1

(Brevibacillus
brevis) 		PF00550
(PP-binding)
PF00668
(Condensation) 		4 ASP A 868
MET A 935
ASN A 859
TYR A 916
 None
 1.49A 1nbiA-5isxA:
0.0		 1nbiA-5isxA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 ARG A 424
ASP A  75
ASN A 325
TYR A 271
 None
 1.45A 1nbiA-5lx8A:
0.0		 1nbiA-5lx8A:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvo FOXE

(Rhodobacter sp.
SW2) 		no annotation 4 ARG A  93
ASP A 228
MET A 230
ASN A 123
 HEC  A 301 (-3.8A)
None
HEC  A 301 (-2.2A)
None
 1.43A 1nbiA-5mvoA:
undetectable		 1nbiA-5mvoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		4 ARG A 428
ASP A 112
ASN A 109
TYR A 300
 FLC  A 501 (-2.8A)
None
None
None
 1.21A 1nbiA-5x9rA:
undetectable		 1nbiA-5x9rA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj PROTEIN CFT1

(Saccharomyces
cerevisiae) 		no annotation 4 ARG A  41
ASP A 421
ASN A 437
TYR A  49
 None
 1.49A 1nbiA-6eojA:
2.1		 1nbiA-6eojA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n CLEAVAGE AND
POLYADENYLATION
SPECIFICITY FACTOR
SUBUNIT 1

(Homo sapiens) 		no annotation 4 ARG A1382
ASP A1342
ASN A 471
TYR A   5
 None
 1.37A 1nbiA-6f9nA:
1.5		 1nbiA-6f9nA:
undetectable