SIMILAR PATTERNS OF AMINO ACIDS FOR 1NBH_D_SAMD3293_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bdm | MALATE DEHYDROGENASE (Thermusthermophilus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 223ALA A 269SER A 286SER A 187HIS A 186 | NoneNoneNoneNoneNAX A 334 (-3.1A) | 1.34A | 1nbhD-1bdmA:6.2 | 1nbhD-1bdmA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1coy | CHOLESTEROL OXIDASE (Brevibacteriumsterolicum) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | TYR A 21GLY A 114VAL A 95ALA A 24SER A 227 | FAD A 510 (-4.4A)FAD A 510 (-3.0A)NoneNoneNone | 1.09A | 1nbhD-1coyA:undetectable | 1nbhD-1coyA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3h | GUANOSINEPENTAPHOSPHATESYNTHETASE (Streptomycesantibioticus) |
PF00013(KH_1)PF01138(RNase_PH)PF03726(PNPase) | 5 | ILE A 198GLY A 158VAL A 186ALA A 141SER A 142 | None | 1.32A | 1nbhD-1e3hA:undetectable | 1nbhD-1e3hA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htr | GASTRICSINPROGASTRICSIN (PROSEGMENT) (Homo sapiens;Homo sapiens) |
PF00026(Asp)PF07966(A1_Propeptide) | 5 | ILE B 180GLY B 170VAL B 315ALA P 1TYR B 176 | None | 1.30A | 1nbhD-1htrB:undetectable | 1nbhD-1htrB:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khu | SMAD1 (Homo sapiens) |
PF03166(MH2) | 5 | ILE A 436GLY A 333VAL A 296SER A 351TYR A 276 | None | 1.35A | 1nbhD-1khuA:undetectable | 1nbhD-1khuA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | ILE A 135GLY A 129VAL A 143SER A 365SER A 369 | NoneNoneNoneXPL A 202 ( 2.7A)None | 0.96A | 1nbhD-1l2qA:undetectable | 1nbhD-1l2qA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lur | ALDOSE 1-EPIMERASE (Caenorhabditiselegans) |
PF01263(Aldose_epim) | 5 | ILE A1146GLY A1058ALA A1055SER A1056TYR A1324 | None | 1.40A | 1nbhD-1lurA:undetectable | 1nbhD-1lurA:23.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pug | HYPOTHETICAL UPF0133PROTEIN YBAB (Escherichiacoli) |
PF02575(YbaB_DNA_bd) | 5 | ILE A 84GLY A 35VAL A 33ALA A 39SER A 37 | None | 1.28A | 1nbhD-1pugA:undetectable | 1nbhD-1pugA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qax | PROTEIN(3-HYDROXY-3-METHYLGLUTARYL-COENZYME AREDUCTASE) (Pseudomonasmevalonii) |
PF00368(HMG-CoA_red) | 5 | TYR A 92ILE A 248GLY A 367ALA A 88MET A 93 | HMG A1002 (-4.0A)NoneHMG A1002 (-4.5A)HMG A1002 (-3.6A)None | 1.21A | 1nbhD-1qaxA:undetectable | 1nbhD-1qaxA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qle | CYTOCHROME C OXIDASEPOLYPEPTIDE I-BETA (Paracoccusdenitrificans) |
PF00115(COX1) | 5 | ILE A 226GLY A 286ALA A 426SER A 291HIS A 292 | None | 1.20A | 1nbhD-1qleA:undetectable | 1nbhD-1qleA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qyc | PHENYLCOUMARANBENZYLIC ETHERREDUCTASE PT1 (Pinus taeda) |
PF05368(NmrA) | 5 | TYR A 159GLY A 168ALA A 165SER A 163SER A 263 | None | 1.37A | 1nbhD-1qycA:5.0 | 1nbhD-1qycA:21.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r8y | GLYCINEN-METHYLTRANSFERASE (Mus musculus) |
PF13847(Methyltransf_31) | 7 | GLY A 66VAL A 69ALA A 86SER A 87MET A 90TRP A 117HIS A 142 | None | 0.64A | 1nbhD-1r8yA:35.1 | 1nbhD-1r8yA:95.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r8y | GLYCINEN-METHYLTRANSFERASE (Mus musculus) |
PF13847(Methyltransf_31) | 7 | GLY A 66VAL A 69ALA A 86SER A 87MET A 90TRP A 117SER A 139 | None | 0.54A | 1nbhD-1r8yA:35.1 | 1nbhD-1r8yA:95.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sde | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Streptomycessp. R61) |
PF00144(Beta-lactamase) | 5 | ILE A 141GLY A 168VAL A 166ALA A 180HIS A 200 | None | 1.19A | 1nbhD-1sdeA:undetectable | 1nbhD-1sdeA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzn | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | TYR A 153ILE A 27GLY A 139ALA A 158SER A 156 | NoneNAP A1249 (-4.1A)NoneNoneNone | 1.15A | 1nbhD-1uznA:3.2 | 1nbhD-1uznA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | GLY A 48SER A 69MET A 72SER A 112HIS A 115 | SAM A 302 (-3.6A)SAM A 302 (-4.7A)SAM A 302 (-3.9A)SAM A 302 (-3.3A)SAM A 302 (-3.8A) | 0.71A | 1nbhD-1ve3A:20.0 | 1nbhD-1ve3A:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vf8 | SECRETORY PROTEIN (Mus musculus) |
PF00704(Glyco_hydro_18) | 5 | ILE A 226GLY A 242VAL A 188ALA A 245SER A 205 | None | 1.22A | 1nbhD-1vf8A:undetectable | 1nbhD-1vf8A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 5 | ILE A 240GLY A 299ALA A 304SER A 302HIS A 68 | NoneNoneNoneNone ZN A 372 (-3.5A) | 1.18A | 1nbhD-1vheA:undetectable | 1nbhD-1vheA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wls | L-ASPARAGINASE (Pyrococcushorikoshii) |
PF00710(Asparaginase) | 5 | TYR A 168ILE A 138GLY A 322HIS A 183TYR A 139 | None | 1.11A | 1nbhD-1wlsA:undetectable | 1nbhD-1wlsA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x87 | UROCANASE PROTEIN (Geobacillusstearothermophilus) |
PF01175(Urocanase)PF17391(Urocanase_N)PF17392(Urocanase_C) | 5 | ILE A 135GLY A 436VAL A 359SER A 131HIS A 439 | None | 1.35A | 1nbhD-1x87A:6.5 | 1nbhD-1x87A:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3v | CELLULASE (Phanerochaetechrysosporium) |
PF00840(Glyco_hydro_7) | 5 | TYR A 106GLY A 167ALA A 162MET A 146SER A 36 | None | 1.14A | 1nbhD-1z3vA:undetectable | 1nbhD-1z3vA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjy | R-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacillusbrevis) |
PF13561(adh_short_C2) | 5 | TYR A 155GLY A 145ALA A 157SER A 158TYR A 189 | SS2 A1260 ( 4.2A)NoneNoneNoneNone | 1.39A | 1nbhD-1zjyA:6.9 | 1nbhD-1zjyA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2avn | UBIQUINONE/MENAQUINONE BIOSYNTHESISMETHYLTRANSFERASE-RELATED PROTEIN (Thermotogamaritima) |
PF08241(Methyltransf_11) | 5 | TYR A 9GLY A 52SER A 73MET A 76TYR A 20 | SAI A1300 (-3.8A)SAI A1300 (-3.5A)SAI A1300 (-4.7A)SAI A1300 ( 4.2A)None | 1.18A | 1nbhD-2avnA:19.5 | 1nbhD-2avnA:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b6n | PROTEINASE K (Serratia sp.GF96) |
PF00082(Peptidase_S8) | 5 | ILE A 10GLY A 78ALA A 53SER A 211HIS A 46 | None | 1.35A | 1nbhD-2b6nA:undetectable | 1nbhD-2b6nA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buj | SERINE/THREONINE-PROTEIN KINASE 16 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 132GLY A 222VAL A 224SER A 271MET A 272 | None | 1.31A | 1nbhD-2bujA:undetectable | 1nbhD-2bujA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cn3 | BETA-1,4-XYLOGLUCANHYDROLASE (Ruminiclostridiumthermocellum) |
PF02012(BNR) | 5 | ILE A 640GLY A 594ALA A 573SER A 574SER A 556 | None | 1.39A | 1nbhD-2cn3A:undetectable | 1nbhD-2cn3A:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dbn | HYPOTHETICAL PROTEINYBIU (Escherichiacoli) |
PF07350(DUF1479) | 5 | ILE A 90ALA A 416SER A 181SER A 152TYR A 66 | None | 1.24A | 1nbhD-2dbnA:undetectable | 1nbhD-2dbnA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e2n | HEXOKINASE (Sulfurisphaeratokodaii) |
PF01869(BcrAD_BadFG) | 5 | TYR A 145ILE A 176GLY A 148VAL A 172SER A 143 | None | 1.36A | 1nbhD-2e2nA:undetectable | 1nbhD-2e2nA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g18 | PHYCOCYANOBILIN:FERREDOXINOXIDOREDUCTASE (Anabaena sp.) |
PF05996(Fe_bilin_red) | 5 | TYR A 130ILE A 202VAL A 194SER A 129HIS A 184 | None | 1.29A | 1nbhD-2g18A:undetectable | 1nbhD-2g18A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 212VAL A 216ALA A 208SER A 444HIS A 348 | NoneNone6NA A1460 (-3.4A)NH4 A1461 ( 4.4A)None | 1.34A | 1nbhD-2iwzA:undetectable | 1nbhD-2iwzA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji9 | OXALYL-COADECARBOXYLASE (Oxalobacterformigenes) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 482SER A 422MET A 428TRP A 285TYR A 483 | TPW A1554 (-4.1A)NoneTPW A1554 (-4.0A)NoneTPW A1554 (-4.8A) | 1.09A | 1nbhD-2ji9A:3.2 | 1nbhD-2ji9A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 5 | ILE A 18GLY A 21VAL A 99ALA A 68SER A 69 | None | 1.23A | 1nbhD-2qzxA:undetectable | 1nbhD-2qzxA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3al0 | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Thermotogamaritima) |
PF01425(Amidase) | 5 | ILE A 456GLY A 436VAL A 425SER A 430TRP A 132 | None | 1.38A | 1nbhD-3al0A:undetectable | 1nbhD-3al0A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3awd | PUTATIVE POLYOLDEHYDROGENASE (Gluconobacteroxydans) |
PF13561(adh_short_C2) | 5 | TYR A 162ILE A 22GLY A 146ALA A 167SER A 165 | None | 1.21A | 1nbhD-3awdA:6.9 | 1nbhD-3awdA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnj | CHOLESTEROL OXIDASE (Streptomycessp. SA-COO) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | TYR A 20GLY A 114VAL A 95ALA A 23SER A 227 | FAD A 510 (-4.5A)FAD A 510 (-3.0A)NoneNoneNone | 1.08A | 1nbhD-3cnjA:2.5 | 1nbhD-3cnjA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cr7 | ADENYLYL-SULFATEKINASE (Penicilliumchrysogenum) |
PF01583(APS_kinase) | 5 | GLY A 37VAL A 140ALA A 42SER A 39TYR A 172 | ADP A2001 (-3.0A)NoneNoneADP A2001 (-2.3A)None | 1.36A | 1nbhD-3cr7A:undetectable | 1nbhD-3cr7A:20.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dc8 | DIHYDROPYRIMIDINASE (Sinorhizobiummeliloti) |
PF01979(Amidohydro_1) | 5 | ILE A 222GLY A 258VAL A 256ALA A 311HIS A 236 | NoneNoneNoneNone ZN A 501 (-3.4A) | 1.39A | 1nbhD-3dc8A:undetectable | 1nbhD-3dc8A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ddn | D-3-PHOSPHOGLYCERATEDEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00389(2-Hacid_dh)PF01842(ACT)PF02826(2-Hacid_dh_C) | 5 | ILE A 9GLY A 293VAL A 18ALA A 288SER A 98 | None | 1.40A | 1nbhD-3ddnA:5.3 | 1nbhD-3ddnA:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dit | PROTEIN MOTHERSAGAINST DPP (Drosophilamelanogaster) |
PF03166(MH2) | 5 | ILE A 426GLY A 323VAL A 286SER A 341TYR A 266 | None | 1.26A | 1nbhD-3ditA:undetectable | 1nbhD-3ditA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 5 | TYR D 327ILE D 472VAL D 293ALA D 331TYR D 473 | None | 1.00A | 1nbhD-3dzuD:undetectable | 1nbhD-3dzuD:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdd | L-ASPARTATE-BETA-DECARBOXYLASE (Comamonastestosteroni) |
PF00155(Aminotran_1_2) | 5 | GLY A 325VAL A 327ALA A 319SER A 314TYR A 180 | NoneNoneNonePLP A 534 (-2.5A)None | 1.38A | 1nbhD-3fddA:undetectable | 1nbhD-3fddA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fr8 | PUTATIVE KETOL-ACIDREDUCTOISOMERASE(OS05G0573700PROTEIN) (Oryza sativa) |
PF01450(IlvC)PF07991(IlvN) | 5 | ILE A 360GLY A 368VAL A 372ALA A 566TYR A 468 | None | 1.38A | 1nbhD-3fr8A:3.8 | 1nbhD-3fr8A:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gmj | PROTEIN MOTHERSAGAINST DPP (Drosophilamelanogaster) |
no annotation | 5 | ILE D 426GLY D 323VAL D 286SER D 341TYR D 266 | None | 1.39A | 1nbhD-3gmjD:undetectable | 1nbhD-3gmjD:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0l | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Aquifexaeolicus) |
PF01425(Amidase) | 5 | GLY A 170VAL A 422SER A 166SER A 124TYR A 303 | ASN A 901 (-3.6A)NoneNoneASN A 901 (-3.0A)None | 1.21A | 1nbhD-3h0lA:undetectable | 1nbhD-3h0lA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 11TRP A 374SER A 44HIS A 45TYR A 329 | NoneNoneNone MG A 402 ( 3.4A)None | 1.27A | 1nbhD-3hpfA:undetectable | 1nbhD-3hpfA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icj | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Pyrococcusfuriosus) |
PF07969(Amidohydro_3) | 5 | TYR A 221ILE A 135VAL A 112ALA A 225SER A 224 | None | 1.22A | 1nbhD-3icjA:undetectable | 1nbhD-3icjA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2g | RESINIFERATOXIN-BINDING,PHOSPHOTRIESTERASE-RELATED PROTEIN (Rhodobactersphaeroides) |
PF02126(PTE) | 5 | ILE A 151GLY A 177SER A 179TRP A 42SER A 138 | NoneNoneNoneDTV A 402 (-3.7A)None | 1.29A | 1nbhD-3k2gA:undetectable | 1nbhD-3k2gA:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfu | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Thermusthermophilus) |
PF01425(Amidase) | 5 | GLY E 164VAL E 411SER E 160SER E 118TYR E 295 | None | 1.18A | 1nbhD-3kfuE:undetectable | 1nbhD-3kfuE:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3la8 | PUTATIVE PURINENUCLEOSIDEPHOSPHORYLASE (Streptococcusmutans) |
PF01048(PNP_UDP_1) | 5 | TYR A 182GLY A 227VAL A 225ALA A 230SER A 229 | None | 1.40A | 1nbhD-3la8A:undetectable | 1nbhD-3la8A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndo | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Mycolicibacteriumsmegmatis) |
PF01791(DeoC) | 5 | ILE A 97VAL A 128ALA A 209MET A 179SER A 192 | NoneNoneNoneNoneUNL A 301 ( 3.7A) | 1.33A | 1nbhD-3ndoA:2.5 | 1nbhD-3ndoA:25.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ng3 | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Mycobacteriumavium) |
PF01791(DeoC) | 5 | ILE A 95VAL A 126ALA A 207MET A 177SER A 190 | NoneNoneNoneNoneUNL A 301 ( 3.6A) | 1.39A | 1nbhD-3ng3A:undetectable | 1nbhD-3ng3A:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzu | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 5 | ILE A 828GLY A 790VAL A 785TRP A 201HIS A 295 | None | 0.96A | 1nbhD-3nzuA:undetectable | 1nbhD-3nzuA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pig | BETA-FRUCTOFURANOSIDASE (Bifidobacteriumlongum) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | ILE A 343GLY A 254VAL A 252ALA A 257SER A 256 | None | 1.05A | 1nbhD-3pigA:undetectable | 1nbhD-3pigA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3px2 | N-METHYLTRANSFERASE (Streptomycesfradiae) |
PF13649(Methyltransf_25) | 5 | TYR A 14GLY A 60SER A 81MET A 84SER A 120 | SAH A 263 ( 3.9A)SAH A 263 (-3.3A)SAH A 263 (-4.7A)SAH A 263 (-4.5A)SAH A 263 (-3.3A) | 0.69A | 1nbhD-3px2A:22.4 | 1nbhD-3px2A:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qt4 | CATHEPSIN-L-LIKEMIDGUT CYSTEINEPROTEINASE (Tenebriomolitor) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 5 | TYR A 73ILE A 151ALA A 235SER A 280TYR A 187 | PG6 A 419 ( 3.6A)NoneNoneNonePG4 A 414 (-4.6A) | 1.15A | 1nbhD-3qt4A:undetectable | 1nbhD-3qt4A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r13 | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Thermotogamaritima) |
PF01791(DeoC) | 5 | ILE A 120VAL A 151ALA A 227MET A 197SER A 210 | NoneNoneNoneNoneUNL A 300 ( 4.1A) | 1.37A | 1nbhD-3r13A:2.2 | 1nbhD-3r13A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tw5 | TRANSGLUTAMINASEELICITOR (Phytophthorasojae) |
PF16683(TGase_elicitor) | 5 | ILE A 457GLY A 201ALA A 321SER A 324TRP A 215 | None | 1.35A | 1nbhD-3tw5A:undetectable | 1nbhD-3tw5A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2g | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | TYR A 180ILE A 43GLY A 165ALA A 185SER A 183 | None | 1.22A | 1nbhD-3v2gA:7.1 | 1nbhD-3v2gA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wfa | ALPHA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF10566(Glyco_hydro_97)PF14508(GH97_N)PF14509(GH97_C) | 5 | ILE A 603GLY A 339ALA A 342MET A 334TYR A 376 | None | 1.40A | 1nbhD-3wfaA:undetectable | 1nbhD-3wfaA:18.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwn | PUTATIVEACETYLGLUTAMATEKINASE-LIKE PROTEIN (Thermusthermophilus) |
PF00696(AA_kinase) | 5 | ILE A 210GLY A 195VAL A 207ALA A 251SER A 191 | None | 1.26A | 1nbhD-3wwnA:undetectable | 1nbhD-3wwnA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | ILE A 122GLY A 69VAL A 71ALA A 66SER A 67 | None | 1.05A | 1nbhD-4a9aA:undetectable | 1nbhD-4a9aA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b8j | IMPORTIN SUBUNITALPHA-1A (Oryza sativa) |
PF00514(Arm)PF01749(IBB)PF16186(Arm_3) | 5 | ILE A 488GLY A 435ALA A 396SER A 398TYR A 492 | None | 1.38A | 1nbhD-4b8jA:undetectable | 1nbhD-4b8jA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpc | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE S (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A1727GLY A1732VAL A1730ALA A1700SER A1699 | None | 1.12A | 1nbhD-4bpcA:undetectable | 1nbhD-4bpcA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpl | IMPORTIN SUBUNITALPHA-1A (Oryza sativa) |
PF00514(Arm)PF16186(Arm_3) | 5 | ILE A 488GLY A 435ALA A 396SER A 398TYR A 492 | None | 1.38A | 1nbhD-4bplA:undetectable | 1nbhD-4bplA:18.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4y | SHORT CHAINDEHYDROGENASE FAMILYPROTEIN (Francisellatularensis) |
PF13561(adh_short_C2) | 5 | TYR A 137ILE A 212GLY A 123VAL A 165SER A 140 | GOL A 306 (-4.8A)NoneNoneNoneNone | 1.34A | 1nbhD-4e4yA:3.3 | 1nbhD-4e4yA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgs | PROBABLEDEHYDROGENASEPROTEIN (Rhizobium etli) |
PF13561(adh_short_C2) | 5 | TYR A 151ILE A 19GLY A 137ALA A 156SER A 154 | None | 1.19A | 1nbhD-4fgsA:7.8 | 1nbhD-4fgsA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4giz | PROTEIN E6 (Alphapapillomavirus9) |
PF00518(E6) | 5 | TYR C 81TRP C 132GLY C 130SER C 80TYR C 92 | None | 1.40A | 1nbhD-4gizC:undetectable | 1nbhD-4gizC:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6f | SERINE/THREONINE-PROTEIN KINASE PLK2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 189GLY A 267VAL A 269SER A 313MET A 314 | None | 1.22A | 1nbhD-4i6fA:undetectable | 1nbhD-4i6fA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | TYR A 187GLY A 234SER A 256MET A 259HIS A 303 | SAH A 501 ( 4.1A)SAH A 501 (-3.6A)SAH A 501 (-4.5A)SAH A 501 (-3.9A)SAH A 501 (-4.0A) | 0.62A | 1nbhD-4ineA:18.0 | 1nbhD-4ineA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | TYR A 183GLY A 230SER A 252MET A 255HIS A 299 | SAH A 701 ( 4.2A)SAH A 701 (-3.5A)SAH A 701 (-4.7A)SAH A 701 (-3.9A)SAH A 701 (-4.2A) | 0.68A | 1nbhD-4kriA:17.9 | 1nbhD-4kriA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mou | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Paenarthrobacteraurescens) |
PF00378(ECH_1) | 5 | ILE A 150GLY A 155ALA A 128SER A 127SER A 97 | None | 1.20A | 1nbhD-4mouA:undetectable | 1nbhD-4mouA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) |
PF05690(ThiG) | 5 | ILE A 180GLY A 195VAL A 193ALA A 169SER A 170 | NoneF6R A 304 (-3.5A)NoneF6R A 304 (-4.7A)None | 1.23A | 1nbhD-4n6fA:undetectable | 1nbhD-4n6fA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p74 | PHENYLALANINE--TRNALIGASE ALPHA SUBUNIT (Pseudomonasaeruginosa) |
PF01409(tRNA-synt_2d) | 5 | ILE C 37GLY C 228VAL C 130ALA C 176MET C 202 | None2U9 C 301 (-3.6A)NoneNoneNone | 1.19A | 1nbhD-4p74C:undetectable | 1nbhD-4p74C:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q80 | SERINE PROTEASE 57 (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 16GLY A 197VAL A 138SER A 54HIS A 57 | NoneNoneNoneNone2YS A 304 (-2.6A) | 1.22A | 1nbhD-4q80A:undetectable | 1nbhD-4q80A:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf3 | NADPH DEPENDENTR-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacilluskefiri) |
PF13561(adh_short_C2) | 5 | TYR A 156GLY A 146ALA A 158SER A 159TYR A 190 | None | 1.32A | 1nbhD-4rf3A:6.9 | 1nbhD-4rf3A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkm | NADH-DEPENDENTREDUCTASE FOR4-DEOXY-L-ERYTHRO-5-HEXOSEULOSE URONATE (Sphingomonassp. A1) |
PF13561(adh_short_C2) | 5 | TYR A 164ILE A 19GLY A 149ALA A 169SER A 167 | NoneSO4 A 303 (-3.5A)NoneNoneNone | 1.25A | 1nbhD-4tkmA:6.7 | 1nbhD-4tkmA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkt | AT-LESS POLYKETIDESYNTHASE (Streptomycesplatensis) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 5 | ILE A3493GLY A3201SER A3198TRP A3180SER A3350 | None | 1.35A | 1nbhD-4tktA:undetectable | 1nbhD-4tktA:19.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tqt | D-HYDANTOINASE (Brucella suis) |
PF01979(Amidohydro_1) | 5 | ILE A 226GLY A 262VAL A 260ALA A 315HIS A 240 | NoneNoneNoneNone ZN A 502 (-3.5A) | 1.37A | 1nbhD-4tqtA:undetectable | 1nbhD-4tqtA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvo | MALATE DEHYDROGENASE (Mycobacteriumtuberculosis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | ILE A 222ALA A 268SER A 284SER A 190HIS A 189 | NA A 410 ( 3.8A)NoneNoneNoneSO4 A 401 (-4.4A) | 1.37A | 1nbhD-4tvoA:6.1 | 1nbhD-4tvoA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvo | L,D-TRANSPEPTIDASE (Mycolicibacteriumsmegmatis) |
PF03734(YkuD) | 5 | ILE A 188GLY A 161ALA A 158SER A 159HIS A 216 | NoneNoneNoneNonePO4 A 501 (-4.0A) | 1.32A | 1nbhD-4xvoA:undetectable | 1nbhD-4xvoA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zg8 | ENDOGLUCANASE (Perinereisbrevicirris) |
PF00759(Glyco_hydro_9) | 5 | TRP A 376GLY A 133ALA A 365SER A 366HIS A 361 | NoneNoneNoneNoneBTB A 505 (-4.4A) | 1.04A | 1nbhD-4zg8A:undetectable | 1nbhD-4zg8A:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b2g | ENDOLYSIN,CLAUDIN-4 (Homo sapiens;Escherichiavirus T4) |
PF00822(PMP22_Claudin)PF00959(Phage_lysozyme) | 5 | TRP A1181ILE A1251GLY A1180VAL A1184ALA A1175 | None | 1.24A | 1nbhD-5b2gA:undetectable | 1nbhD-5b2gA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by2 | PHOSPHOHEPTOSEISOMERASE (Colwelliapsychrerythraea) |
PF13580(SIS_2) | 5 | ILE A 86GLY A 48ALA A 141SER A 122TYR A 95 | None | 1.21A | 1nbhD-5by2A:2.4 | 1nbhD-5by2A:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dbt | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Streptococcussuis) |
PF01791(DeoC) | 5 | ILE A 92VAL A 123ALA A 199MET A 169SER A 182 | None | 1.30A | 1nbhD-5dbtA:undetectable | 1nbhD-5dbtA:25.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epo | 7-ALPHA-HYDROXYSTEROID DEYDROGENASE (Clostridiumsardiniense) |
PF13561(adh_short_C2) | 5 | ILE A 165VAL A 121ALA A 23SER A 22SER A 13 | NoneNoneNoneNoneNAP A 301 (-3.0A) | 1.33A | 1nbhD-5epoA:3.5 | 1nbhD-5epoA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fub | PROTEIN ARGININEMETHYLTRANSFERASE 2 (Danio rerio) |
PF13649(Methyltransf_25) | 5 | TYR A 84GLY A 125VAL A 128ALA A 147SER A 148 | SAH A 409 ( 3.6A)SAH A 409 ( 3.7A)NoneSAH A 409 (-3.5A)SAH A 409 ( 4.2A) | 0.71A | 1nbhD-5fubA:8.5 | 1nbhD-5fubA:23.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gzt | CHITINASE (Paenibacillussp. FPU-7) |
PF00704(Glyco_hydro_18) | 5 | VAL B 850ALA B 869SER B 886SER B 817HIS B 779 | FMT B4011 (-4.8A)NoneNoneNoneNone | 1.40A | 1nbhD-5gztB:undetectable | 1nbhD-5gztB:14.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h02 | GLYCINE SARCOSINEN-METHYLTRANSFERASE (Methanohalophilusportucalensis) |
PF13649(Methyltransf_25) | 5 | GLY A 69SER A 90MET A 93TRP A 115SER A 135 | SAH A 301 (-3.3A)SAH A 301 ( 4.9A)SAH A 301 (-3.9A)SAH A 301 (-3.6A)SAH A 301 (-3.1A) | 0.64A | 1nbhD-5h02A:26.2 | 1nbhD-5h02A:30.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipy | FLAVIN-CONTAININGMONOOXYGENASE (Roseovariusnubinhibens) |
PF00743(FMO-like) | 5 | TYR A 417ILE A 370GLY A 74SER A 96HIS A 404 | None | 1.19A | 1nbhD-5ipyA:2.1 | 1nbhD-5ipyA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6o | B-GLUCOSIDASE (metagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ILE A 656GLY A 257ALA A 230SER A 238TYR A 657 | None | 1.34A | 1nbhD-5k6oA:undetectable | 1nbhD-5k6oA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ksh | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | ILE A 179GLY A 76VAL A 78ALA A 73TYR A 169 | None | 1.35A | 1nbhD-5kshA:undetectable | 1nbhD-5kshA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kzm | TRYPTOPHAN SYNTHASEBETA CHAIN (Francisellatularensis) |
PF00291(PALP) | 5 | GLY B 231VAL B 308ALA B 301SER B 300SER B 296 | LLP B 86 ( 3.7A)NoneNoneNone CA B 402 (-4.2A) | 1.38A | 1nbhD-5kzmB:undetectable | 1nbhD-5kzmB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opt | 40S RIBOSOMALPROTEIN S2640S RIBOSOMALPROTEIN S3A-2 (Trypanosomacruzi;Trypanosomacruzi) |
no annotationno annotation | 5 | TYR T 62GLY T 65ALA T 56SER T 59TYR W 83 | None | 1.25A | 1nbhD-5optT:undetectable | 1nbhD-5optT:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2w | SHORT CHAINDEHYDROGENASE (Burkholderiacenocepacia) |
PF00106(adh_short) | 5 | TYR A 155ILE A 18GLY A 140ALA A 160SER A 158 | IMD A 304 ( 4.3A)NAP A 301 (-4.0A)NoneNoneNone | 1.21A | 1nbhD-5u2wA:5.9 | 1nbhD-5u2wA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v12 | HERCYNYLCYSTEINESULFOXIDE LYASE (Neurosporacrassa) |
no annotation | 5 | GLY C 199VAL C 194ALA C 437MET C 197SER C 440 | NoneNoneNoneFMT C 501 ( 4.9A)None | 1.31A | 1nbhD-5v12C:undetectable | 1nbhD-5v12C:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | TYR A 246GLY A 292SER A 314MET A 317HIS A 360 | SAH A 703 ( 4.0A)SAH A 703 ( 3.7A)SAH A 703 (-4.5A)SAH A 703 (-3.8A)SAH A 703 (-4.0A) | 0.82A | 1nbhD-5wp4A:17.2 | 1nbhD-5wp4A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 5 | ILE A 694GLY A 286ALA A 259SER A 267TYR A 695 | None | 1.35A | 1nbhD-5wugA:undetectable | 1nbhD-5wugA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zbi | PEPTIDE ASPARAGINYLLIGASE (Violacanadensis) |
no annotation | 5 | ILE A 85GLY A 78VAL A 80ALA A 317TYR A 72 | None | 1.40A | 1nbhD-5zbiA:undetectable | 1nbhD-5zbiA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f0k | ACTF (Rhodothermusmarinus) |
no annotation | 5 | TRP F 169ILE F 168ALA F 236SER F 238TYR F 165 | None | 1.40A | 1nbhD-6f0kF:undetectable | 1nbhD-6f0kF:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fwf | NITRIC-OXIDEREDUCTASE (Neisseriameningitidis) |
no annotation | 5 | GLY A 547VAL A 29ALA A 200SER A 199TRP A 215 | None | 1.33A | 1nbhD-6fwfA:undetectable | 1nbhD-6fwfA:undetectable |