SIMILAR PATTERNS OF AMINO ACIDS FOR 1NBH_D_SAMD3293_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 223
ALA A 269
SER A 286
SER A 187
HIS A 186
None
None
None
None
NAX  A 334 (-3.1A)
1.34A 1nbhD-1bdmA:
6.2
1nbhD-1bdmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 TYR A  21
GLY A 114
VAL A  95
ALA A  24
SER A 227
FAD  A 510 (-4.4A)
FAD  A 510 (-3.0A)
None
None
None
1.09A 1nbhD-1coyA:
undetectable
1nbhD-1coyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE


(Streptomyces
antibioticus)
PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase)
5 ILE A 198
GLY A 158
VAL A 186
ALA A 141
SER A 142
None
1.32A 1nbhD-1e3hA:
undetectable
1nbhD-1e3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)


(Homo sapiens;
Homo sapiens)
PF00026
(Asp)
PF07966
(A1_Propeptide)
5 ILE B 180
GLY B 170
VAL B 315
ALA P   1
TYR B 176
None
1.30A 1nbhD-1htrB:
undetectable
1nbhD-1htrB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khu SMAD1

(Homo sapiens)
PF03166
(MH2)
5 ILE A 436
GLY A 333
VAL A 296
SER A 351
TYR A 276
None
1.35A 1nbhD-1khuA:
undetectable
1nbhD-1khuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE


(Methanosarcina
barkeri)
PF05369
(MtmB)
5 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
None
None
None
XPL  A 202 ( 2.7A)
None
0.96A 1nbhD-1l2qA:
undetectable
1nbhD-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans)
PF01263
(Aldose_epim)
5 ILE A1146
GLY A1058
ALA A1055
SER A1056
TYR A1324
None
1.40A 1nbhD-1lurA:
undetectable
1nbhD-1lurA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pug HYPOTHETICAL UPF0133
PROTEIN YBAB


(Escherichia
coli)
PF02575
(YbaB_DNA_bd)
5 ILE A  84
GLY A  35
VAL A  33
ALA A  39
SER A  37
None
1.28A 1nbhD-1pugA:
undetectable
1nbhD-1pugA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)


(Pseudomonas
mevalonii)
PF00368
(HMG-CoA_red)
5 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
1.21A 1nbhD-1qaxA:
undetectable
1nbhD-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA


(Paracoccus
denitrificans)
PF00115
(COX1)
5 ILE A 226
GLY A 286
ALA A 426
SER A 291
HIS A 292
None
1.20A 1nbhD-1qleA:
undetectable
1nbhD-1qleA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1


(Pinus taeda)
PF05368
(NmrA)
5 TYR A 159
GLY A 168
ALA A 165
SER A 163
SER A 263
None
1.37A 1nbhD-1qycA:
5.0
1nbhD-1qycA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r8y GLYCINE
N-METHYLTRANSFERASE


(Mus musculus)
PF13847
(Methyltransf_31)
7 GLY A  66
VAL A  69
ALA A  86
SER A  87
MET A  90
TRP A 117
HIS A 142
None
0.64A 1nbhD-1r8yA:
35.1
1nbhD-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r8y GLYCINE
N-METHYLTRANSFERASE


(Mus musculus)
PF13847
(Methyltransf_31)
7 GLY A  66
VAL A  69
ALA A  86
SER A  87
MET A  90
TRP A 117
SER A 139
None
0.54A 1nbhD-1r8yA:
35.1
1nbhD-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE


(Streptomyces
sp. R61)
PF00144
(Beta-lactamase)
5 ILE A 141
GLY A 168
VAL A 166
ALA A 180
HIS A 200
None
1.19A 1nbhD-1sdeA:
undetectable
1nbhD-1sdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
None
NAP  A1249 (-4.1A)
None
None
None
1.15A 1nbhD-1uznA:
3.2
1nbhD-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226


(Pyrococcus
horikoshii)
PF13649
(Methyltransf_25)
5 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
0.71A 1nbhD-1ve3A:
20.0
1nbhD-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus)
PF00704
(Glyco_hydro_18)
5 ILE A 226
GLY A 242
VAL A 188
ALA A 245
SER A 205
None
1.22A 1nbhD-1vf8A:
undetectable
1nbhD-1vf8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG


(Bacillus
subtilis)
PF05343
(Peptidase_M42)
5 ILE A 240
GLY A 299
ALA A 304
SER A 302
HIS A  68
None
None
None
None
ZN  A 372 (-3.5A)
1.18A 1nbhD-1vheA:
undetectable
1nbhD-1vheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii)
PF00710
(Asparaginase)
5 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
None
1.11A 1nbhD-1wlsA:
undetectable
1nbhD-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus)
PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C)
5 ILE A 135
GLY A 436
VAL A 359
SER A 131
HIS A 439
None
1.35A 1nbhD-1x87A:
6.5
1nbhD-1x87A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium)
PF00840
(Glyco_hydro_7)
5 TYR A 106
GLY A 167
ALA A 162
MET A 146
SER A  36
None
1.14A 1nbhD-1z3vA:
undetectable
1nbhD-1z3vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE


(Lactobacillus
brevis)
PF13561
(adh_short_C2)
5 TYR A 155
GLY A 145
ALA A 157
SER A 158
TYR A 189
SS2  A1260 ( 4.2A)
None
None
None
None
1.39A 1nbhD-1zjyA:
6.9
1nbhD-1zjyA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN


(Thermotoga
maritima)
PF08241
(Methyltransf_11)
5 TYR A   9
GLY A  52
SER A  73
MET A  76
TYR A  20
SAI  A1300 (-3.8A)
SAI  A1300 (-3.5A)
SAI  A1300 (-4.7A)
SAI  A1300 ( 4.2A)
None
1.18A 1nbhD-2avnA:
19.5
1nbhD-2avnA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96)
PF00082
(Peptidase_S8)
5 ILE A  10
GLY A  78
ALA A  53
SER A 211
HIS A  46
None
1.35A 1nbhD-2b6nA:
undetectable
1nbhD-2b6nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 132
GLY A 222
VAL A 224
SER A 271
MET A 272
None
1.31A 1nbhD-2bujA:
undetectable
1nbhD-2bujA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE


(Ruminiclostridium
thermocellum)
PF02012
(BNR)
5 ILE A 640
GLY A 594
ALA A 573
SER A 574
SER A 556
None
1.39A 1nbhD-2cn3A:
undetectable
1nbhD-2cn3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU


(Escherichia
coli)
PF07350
(DUF1479)
5 ILE A  90
ALA A 416
SER A 181
SER A 152
TYR A  66
None
1.24A 1nbhD-2dbnA:
undetectable
1nbhD-2dbnA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii)
PF01869
(BcrAD_BadFG)
5 TYR A 145
ILE A 176
GLY A 148
VAL A 172
SER A 143
None
1.36A 1nbhD-2e2nA:
undetectable
1nbhD-2e2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE


(Anabaena sp.)
PF05996
(Fe_bilin_red)
5 TYR A 130
ILE A 202
VAL A 194
SER A 129
HIS A 184
None
1.29A 1nbhD-2g18A:
undetectable
1nbhD-2g18A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE


(Homo sapiens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A 212
VAL A 216
ALA A 208
SER A 444
HIS A 348
None
None
6NA  A1460 (-3.4A)
NH4  A1461 ( 4.4A)
None
1.34A 1nbhD-2iwzA:
undetectable
1nbhD-2iwzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE


(Oxalobacter
formigenes)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 ILE A 482
SER A 422
MET A 428
TRP A 285
TYR A 483
TPW  A1554 (-4.1A)
None
TPW  A1554 (-4.0A)
None
TPW  A1554 (-4.8A)
1.09A 1nbhD-2ji9A:
3.2
1nbhD-2ji9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans)
PF00026
(Asp)
5 ILE A  18
GLY A  21
VAL A  99
ALA A  68
SER A  69
None
1.23A 1nbhD-2qzxA:
undetectable
1nbhD-2qzxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Thermotoga
maritima)
PF01425
(Amidase)
5 ILE A 456
GLY A 436
VAL A 425
SER A 430
TRP A 132
None
1.38A 1nbhD-3al0A:
undetectable
1nbhD-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awd PUTATIVE POLYOL
DEHYDROGENASE


(Gluconobacter
oxydans)
PF13561
(adh_short_C2)
5 TYR A 162
ILE A  22
GLY A 146
ALA A 167
SER A 165
None
1.21A 1nbhD-3awdA:
6.9
1nbhD-3awdA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO)
PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C)
5 TYR A  20
GLY A 114
VAL A  95
ALA A  23
SER A 227
FAD  A 510 (-4.5A)
FAD  A 510 (-3.0A)
None
None
None
1.08A 1nbhD-3cnjA:
2.5
1nbhD-3cnjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr7 ADENYLYL-SULFATE
KINASE


(Penicillium
chrysogenum)
PF01583
(APS_kinase)
5 GLY A  37
VAL A 140
ALA A  42
SER A  39
TYR A 172
ADP  A2001 (-3.0A)
None
None
ADP  A2001 (-2.3A)
None
1.36A 1nbhD-3cr7A:
undetectable
1nbhD-3cr7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti)
PF01979
(Amidohydro_1)
5 ILE A 222
GLY A 258
VAL A 256
ALA A 311
HIS A 236
None
None
None
None
ZN  A 501 (-3.4A)
1.39A 1nbhD-3dc8A:
undetectable
1nbhD-3dc8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C)
5 ILE A   9
GLY A 293
VAL A  18
ALA A 288
SER A  98
None
1.40A 1nbhD-3ddnA:
5.3
1nbhD-3ddnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dit PROTEIN MOTHERS
AGAINST DPP


(Drosophila
melanogaster)
PF03166
(MH2)
5 ILE A 426
GLY A 323
VAL A 286
SER A 341
TYR A 266
None
1.26A 1nbhD-3ditA:
undetectable
1nbhD-3ditA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA


(Homo sapiens)
PF00104
(Hormone_recep)
PF00105
(zf-C4)
5 TYR D 327
ILE D 472
VAL D 293
ALA D 331
TYR D 473
None
1.00A 1nbhD-3dzuD:
undetectable
1nbhD-3dzuD:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE


(Comamonas
testosteroni)
PF00155
(Aminotran_1_2)
5 GLY A 325
VAL A 327
ALA A 319
SER A 314
TYR A 180
None
None
None
PLP  A 534 (-2.5A)
None
1.38A 1nbhD-3fddA:
undetectable
1nbhD-3fddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)


(Oryza sativa)
PF01450
(IlvC)
PF07991
(IlvN)
5 ILE A 360
GLY A 368
VAL A 372
ALA A 566
TYR A 468
None
1.38A 1nbhD-3fr8A:
3.8
1nbhD-3fr8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmj PROTEIN MOTHERS
AGAINST DPP


(Drosophila
melanogaster)
no annotation 5 ILE D 426
GLY D 323
VAL D 286
SER D 341
TYR D 266
None
1.39A 1nbhD-3gmjD:
undetectable
1nbhD-3gmjD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Aquifex
aeolicus)
PF01425
(Amidase)
5 GLY A 170
VAL A 422
SER A 166
SER A 124
TYR A 303
ASN  A 901 (-3.6A)
None
None
ASN  A 901 (-3.0A)
None
1.21A 1nbhD-3h0lA:
undetectable
1nbhD-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE


(Oceanobacillus
iheyensis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 VAL A  11
TRP A 374
SER A  44
HIS A  45
TYR A 329
None
None
None
MG  A 402 ( 3.4A)
None
1.27A 1nbhD-3hpfA:
undetectable
1nbhD-3hpfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Pyrococcus
furiosus)
PF07969
(Amidohydro_3)
5 TYR A 221
ILE A 135
VAL A 112
ALA A 225
SER A 224
None
1.22A 1nbhD-3icjA:
undetectable
1nbhD-3icjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN


(Rhodobacter
sphaeroides)
PF02126
(PTE)
5 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
None
None
None
DTV  A 402 (-3.7A)
None
1.29A 1nbhD-3k2gA:
undetectable
1nbhD-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A


(Thermus
thermophilus)
PF01425
(Amidase)
5 GLY E 164
VAL E 411
SER E 160
SER E 118
TYR E 295
None
1.18A 1nbhD-3kfuE:
undetectable
1nbhD-3kfuE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE


(Streptococcus
mutans)
PF01048
(PNP_UDP_1)
5 TYR A 182
GLY A 227
VAL A 225
ALA A 230
SER A 229
None
1.40A 1nbhD-3la8A:
undetectable
1nbhD-3la8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Mycolicibacterium
smegmatis)
PF01791
(DeoC)
5 ILE A  97
VAL A 128
ALA A 209
MET A 179
SER A 192
None
None
None
None
UNL  A 301 ( 3.7A)
1.33A 1nbhD-3ndoA:
2.5
1nbhD-3ndoA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng3 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Mycobacterium
avium)
PF01791
(DeoC)
5 ILE A  95
VAL A 126
ALA A 207
MET A 177
SER A 190
None
None
None
None
UNL  A 301 ( 3.6A)
1.39A 1nbhD-3ng3A:
undetectable
1nbhD-3ng3A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM


(Homo sapiens)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
5 ILE A 828
GLY A 790
VAL A 785
TRP A 201
HIS A 295
None
0.96A 1nbhD-3nzuA:
undetectable
1nbhD-3nzuA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE


(Bifidobacterium
longum)
PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C)
5 ILE A 343
GLY A 254
VAL A 252
ALA A 257
SER A 256
None
1.05A 1nbhD-3pigA:
undetectable
1nbhD-3pigA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae)
PF13649
(Methyltransf_25)
5 TYR A  14
GLY A  60
SER A  81
MET A  84
SER A 120
SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
0.69A 1nbhD-3px2A:
22.4
1nbhD-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE


(Tenebrio
molitor)
PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29)
5 TYR A  73
ILE A 151
ALA A 235
SER A 280
TYR A 187
PG6  A 419 ( 3.6A)
None
None
None
PG4  A 414 (-4.6A)
1.15A 1nbhD-3qt4A:
undetectable
1nbhD-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r13 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Thermotoga
maritima)
PF01791
(DeoC)
5 ILE A 120
VAL A 151
ALA A 227
MET A 197
SER A 210
None
None
None
None
UNL  A 300 ( 4.1A)
1.37A 1nbhD-3r13A:
2.2
1nbhD-3r13A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR


(Phytophthora
sojae)
PF16683
(TGase_elicitor)
5 ILE A 457
GLY A 201
ALA A 321
SER A 324
TRP A 215
None
1.35A 1nbhD-3tw5A:
undetectable
1nbhD-3tw5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE


(Sinorhizobium
meliloti)
PF13561
(adh_short_C2)
5 TYR A 180
ILE A  43
GLY A 165
ALA A 185
SER A 183
None
1.22A 1nbhD-3v2gA:
7.1
1nbhD-3v2gA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron)
PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C)
5 ILE A 603
GLY A 339
ALA A 342
MET A 334
TYR A 376
None
1.40A 1nbhD-3wfaA:
undetectable
1nbhD-3wfaA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN


(Thermus
thermophilus)
PF00696
(AA_kinase)
5 ILE A 210
GLY A 195
VAL A 207
ALA A 251
SER A 191
None
1.26A 1nbhD-3wwnA:
undetectable
1nbhD-3wwnA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1


(Saccharomyces
cerevisiae)
PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn)
5 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
None
1.05A 1nbhD-4a9aA:
undetectable
1nbhD-4a9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A


(Oryza sativa)
PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3)
5 ILE A 488
GLY A 435
ALA A 396
SER A 398
TYR A 492
None
1.38A 1nbhD-4b8jA:
undetectable
1nbhD-4b8jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S


(Homo sapiens)
PF00102
(Y_phosphatase)
5 ILE A1727
GLY A1732
VAL A1730
ALA A1700
SER A1699
None
1.12A 1nbhD-4bpcA:
undetectable
1nbhD-4bpcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A


(Oryza sativa)
PF00514
(Arm)
PF16186
(Arm_3)
5 ILE A 488
GLY A 435
ALA A 396
SER A 398
TYR A 492
None
1.38A 1nbhD-4bplA:
undetectable
1nbhD-4bplA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN


(Francisella
tularensis)
PF13561
(adh_short_C2)
5 TYR A 137
ILE A 212
GLY A 123
VAL A 165
SER A 140
GOL  A 306 (-4.8A)
None
None
None
None
1.34A 1nbhD-4e4yA:
3.3
1nbhD-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN


(Rhizobium etli)
PF13561
(adh_short_C2)
5 TYR A 151
ILE A  19
GLY A 137
ALA A 156
SER A 154
None
1.19A 1nbhD-4fgsA:
7.8
1nbhD-4fgsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz PROTEIN E6

(Alphapapillomavirus
9)
PF00518
(E6)
5 TYR C  81
TRP C 132
GLY C 130
SER C  80
TYR C  92
None
1.40A 1nbhD-4gizC:
undetectable
1nbhD-4gizC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 189
GLY A 267
VAL A 269
SER A 313
MET A 314
None
1.22A 1nbhD-4i6fA:
undetectable
1nbhD-4i6fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans)
PF08241
(Methyltransf_11)
5 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
0.62A 1nbhD-4ineA:
18.0
1nbhD-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2


(Haemonchus
contortus)
PF08241
(Methyltransf_11)
5 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
0.68A 1nbhD-4kriA:
17.9
1nbhD-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN


(Paenarthrobacter
aurescens)
PF00378
(ECH_1)
5 ILE A 150
GLY A 155
ALA A 128
SER A 127
SER A  97
None
1.20A 1nbhD-4mouA:
undetectable
1nbhD-4mouA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE


(Amycolatopsis
orientalis)
PF05690
(ThiG)
5 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
1.23A 1nbhD-4n6fA:
undetectable
1nbhD-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT


(Pseudomonas
aeruginosa)
PF01409
(tRNA-synt_2d)
5 ILE C  37
GLY C 228
VAL C 130
ALA C 176
MET C 202
None
2U9  C 301 (-3.6A)
None
None
None
1.19A 1nbhD-4p74C:
undetectable
1nbhD-4p74C:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q80 SERINE PROTEASE 57

(Homo sapiens)
PF00089
(Trypsin)
5 ILE A  16
GLY A 197
VAL A 138
SER A  54
HIS A  57
None
None
None
None
2YS  A 304 (-2.6A)
1.22A 1nbhD-4q80A:
undetectable
1nbhD-4q80A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE


(Lactobacillus
kefiri)
PF13561
(adh_short_C2)
5 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
None
1.32A 1nbhD-4rf3A:
6.9
1nbhD-4rf3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE


(Sphingomonas
sp. A1)
PF13561
(adh_short_C2)
5 TYR A 164
ILE A  19
GLY A 149
ALA A 169
SER A 167
None
SO4  A 303 (-3.5A)
None
None
None
1.25A 1nbhD-4tkmA:
6.7
1nbhD-4tkmA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE


(Streptomyces
platensis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ILE A3493
GLY A3201
SER A3198
TRP A3180
SER A3350
None
1.35A 1nbhD-4tktA:
undetectable
1nbhD-4tktA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis)
PF01979
(Amidohydro_1)
5 ILE A 226
GLY A 262
VAL A 260
ALA A 315
HIS A 240
None
None
None
None
ZN  A 502 (-3.5A)
1.37A 1nbhD-4tqtA:
undetectable
1nbhD-4tqtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ILE A 222
ALA A 268
SER A 284
SER A 190
HIS A 189
NA  A 410 ( 3.8A)
None
None
None
SO4  A 401 (-4.4A)
1.37A 1nbhD-4tvoA:
6.1
1nbhD-4tvoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvo L,D-TRANSPEPTIDASE

(Mycolicibacterium
smegmatis)
PF03734
(YkuD)
5 ILE A 188
GLY A 161
ALA A 158
SER A 159
HIS A 216
None
None
None
None
PO4  A 501 (-4.0A)
1.32A 1nbhD-4xvoA:
undetectable
1nbhD-4xvoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris)
PF00759
(Glyco_hydro_9)
5 TRP A 376
GLY A 133
ALA A 365
SER A 366
HIS A 361
None
None
None
None
BTB  A 505 (-4.4A)
1.04A 1nbhD-4zg8A:
undetectable
1nbhD-4zg8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g ENDOLYSIN,CLAUDIN-4

(Homo sapiens;
Escherichia
virus T4)
PF00822
(PMP22_Claudin)
PF00959
(Phage_lysozyme)
5 TRP A1181
ILE A1251
GLY A1180
VAL A1184
ALA A1175
None
1.24A 1nbhD-5b2gA:
undetectable
1nbhD-5b2gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by2 PHOSPHOHEPTOSE
ISOMERASE


(Colwellia
psychrerythraea)
PF13580
(SIS_2)
5 ILE A  86
GLY A  48
ALA A 141
SER A 122
TYR A  95
None
1.21A 1nbhD-5by2A:
2.4
1nbhD-5by2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Streptococcus
suis)
PF01791
(DeoC)
5 ILE A  92
VAL A 123
ALA A 199
MET A 169
SER A 182
None
1.30A 1nbhD-5dbtA:
undetectable
1nbhD-5dbtA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE


(Clostridium
sardiniense)
PF13561
(adh_short_C2)
5 ILE A 165
VAL A 121
ALA A  23
SER A  22
SER A  13
None
None
None
None
NAP  A 301 (-3.0A)
1.33A 1nbhD-5epoA:
3.5
1nbhD-5epoA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2


(Danio rerio)
PF13649
(Methyltransf_25)
5 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
0.71A 1nbhD-5fubA:
8.5
1nbhD-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7)
PF00704
(Glyco_hydro_18)
5 VAL B 850
ALA B 869
SER B 886
SER B 817
HIS B 779
FMT  B4011 (-4.8A)
None
None
None
None
1.40A 1nbhD-5gztB:
undetectable
1nbhD-5gztB:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE


(Methanohalophilus
portucalensis)
PF13649
(Methyltransf_25)
5 GLY A  69
SER A  90
MET A  93
TRP A 115
SER A 135
SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.1A)
0.64A 1nbhD-5h02A:
26.2
1nbhD-5h02A:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE


(Roseovarius
nubinhibens)
PF00743
(FMO-like)
5 TYR A 417
ILE A 370
GLY A  74
SER A  96
HIS A 404
None
1.19A 1nbhD-5ipyA:
2.1
1nbhD-5ipyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 ILE A 656
GLY A 257
ALA A 230
SER A 238
TYR A 657
None
1.34A 1nbhD-5k6oA:
undetectable
1nbhD-5k6oA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2


(Neisseria
gonorrhoeae)
PF00905
(Transpeptidase)
PF03717
(PBP_dimer)
5 ILE A 179
GLY A  76
VAL A  78
ALA A  73
TYR A 169
None
1.35A 1nbhD-5kshA:
undetectable
1nbhD-5kshA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN


(Francisella
tularensis)
PF00291
(PALP)
5 GLY B 231
VAL B 308
ALA B 301
SER B 300
SER B 296
LLP  B  86 ( 3.7A)
None
None
None
CA  B 402 (-4.2A)
1.38A 1nbhD-5kzmB:
undetectable
1nbhD-5kzmB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S26
40S RIBOSOMAL
PROTEIN S3A-2


(Trypanosoma
cruzi;
Trypanosoma
cruzi)
no annotation
no annotation
5 TYR T  62
GLY T  65
ALA T  56
SER T  59
TYR W  83
None
1.25A 1nbhD-5optT:
undetectable
1nbhD-5optT:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE


(Burkholderia
cenocepacia)
PF00106
(adh_short)
5 TYR A 155
ILE A  18
GLY A 140
ALA A 160
SER A 158
IMD  A 304 ( 4.3A)
NAP  A 301 (-4.0A)
None
None
None
1.21A 1nbhD-5u2wA:
5.9
1nbhD-5u2wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE


(Neurospora
crassa)
no annotation 5 GLY C 199
VAL C 194
ALA C 437
MET C 197
SER C 440
None
None
None
FMT  C 501 ( 4.9A)
None
1.31A 1nbhD-5v12C:
undetectable
1nbhD-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1


(Arabidopsis
thaliana)
no annotation 5 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
0.82A 1nbhD-5wp4A:
17.2
1nbhD-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii)
no annotation 5 ILE A 694
GLY A 286
ALA A 259
SER A 267
TYR A 695
None
1.35A 1nbhD-5wugA:
undetectable
1nbhD-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE


(Viola
canadensis)
no annotation 5 ILE A  85
GLY A  78
VAL A  80
ALA A 317
TYR A  72
None
1.40A 1nbhD-5zbiA:
undetectable
1nbhD-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus)
no annotation 5 TRP F 169
ILE F 168
ALA F 236
SER F 238
TYR F 165
None
1.40A 1nbhD-6f0kF:
undetectable
1nbhD-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE


(Neisseria
meningitidis)
no annotation 5 GLY A 547
VAL A  29
ALA A 200
SER A 199
TRP A 215
None
1.33A 1nbhD-6fwfA:
undetectable
1nbhD-6fwfA:
undetectable