SIMILAR PATTERNS OF AMINO ACIDS FOR 1NBH_D_SAMD3293

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 223
ALA A 269
SER A 286
SER A 187
HIS A 186
 None
None
None
None
NAX  A 334 (-3.1A)
 1.34A 1nbhD-1bdmA:
6.2		 1nbhD-1bdmA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coy CHOLESTEROL OXIDASE

(Brevibacterium
sterolicum) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A  21
GLY A 114
VAL A  95
ALA A  24
SER A 227
 FAD  A 510 (-4.4A)
FAD  A 510 (-3.0A)
None
None
None
 1.09A 1nbhD-1coyA:
undetectable		 1nbhD-1coyA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		5 ILE A 198
GLY A 158
VAL A 186
ALA A 141
SER A 142
 None
 1.32A 1nbhD-1e3hA:
undetectable		 1nbhD-1e3hA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htr GASTRICSIN
PROGASTRICSIN (PRO
SEGMENT)

(Homo sapiens;
Homo sapiens) 		PF00026
(Asp)
PF07966
(A1_Propeptide) 		5 ILE B 180
GLY B 170
VAL B 315
ALA P   1
TYR B 176
 None
 1.30A 1nbhD-1htrB:
undetectable		 1nbhD-1htrB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1khu SMAD1

(Homo sapiens) 		PF03166
(MH2) 		5 ILE A 436
GLY A 333
VAL A 296
SER A 351
TYR A 276
 None
 1.35A 1nbhD-1khuA:
undetectable		 1nbhD-1khuA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		5 ILE A 135
GLY A 129
VAL A 143
SER A 365
SER A 369
 None
None
None
XPL  A 202 ( 2.7A)
None
 0.96A 1nbhD-1l2qA:
undetectable		 1nbhD-1l2qA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lur ALDOSE 1-EPIMERASE

(Caenorhabditis
elegans) 		PF01263
(Aldose_epim) 		5 ILE A1146
GLY A1058
ALA A1055
SER A1056
TYR A1324
 None
 1.40A 1nbhD-1lurA:
undetectable		 1nbhD-1lurA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pug HYPOTHETICAL UPF0133
PROTEIN YBAB

(Escherichia
coli) 		PF02575
(YbaB_DNA_bd) 		5 ILE A  84
GLY A  35
VAL A  33
ALA A  39
SER A  37
 None
 1.28A 1nbhD-1pugA:
undetectable		 1nbhD-1pugA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		5 TYR A  92
ILE A 248
GLY A 367
ALA A  88
MET A  93
 HMG  A1002 (-4.0A)
None
HMG  A1002 (-4.5A)
HMG  A1002 (-3.6A)
None
 1.21A 1nbhD-1qaxA:
undetectable		 1nbhD-1qaxA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 ILE A 226
GLY A 286
ALA A 426
SER A 291
HIS A 292
 None
 1.20A 1nbhD-1qleA:
undetectable		 1nbhD-1qleA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qyc PHENYLCOUMARAN
BENZYLIC ETHER
REDUCTASE PT1

(Pinus taeda) 		PF05368
(NmrA) 		5 TYR A 159
GLY A 168
ALA A 165
SER A 163
SER A 263
 None
 1.37A 1nbhD-1qycA:
5.0		 1nbhD-1qycA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		7 GLY A  66
VAL A  69
ALA A  86
SER A  87
MET A  90
TRP A 117
HIS A 142
 None
 0.64A 1nbhD-1r8yA:
35.1		 1nbhD-1r8yA:
95.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		7 GLY A  66
VAL A  69
ALA A  86
SER A  87
MET A  90
TRP A 117
SER A 139
 None
 0.54A 1nbhD-1r8yA:
35.1		 1nbhD-1r8yA:
95.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		5 ILE A 141
GLY A 168
VAL A 166
ALA A 180
HIS A 200
 None
 1.19A 1nbhD-1sdeA:
undetectable		 1nbhD-1sdeA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 TYR A 153
ILE A  27
GLY A 139
ALA A 158
SER A 156
 None
NAP  A1249 (-4.1A)
None
None
None
 1.15A 1nbhD-1uznA:
3.2		 1nbhD-1uznA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve3 HYPOTHETICAL PROTEIN
PH0226

(Pyrococcus
horikoshii) 		PF13649
(Methyltransf_25) 		5 GLY A  48
SER A  69
MET A  72
SER A 112
HIS A 115
 SAM  A 302 (-3.6A)
SAM  A 302 (-4.7A)
SAM  A 302 (-3.9A)
SAM  A 302 (-3.3A)
SAM  A 302 (-3.8A)
 0.71A 1nbhD-1ve3A:
20.0		 1nbhD-1ve3A:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		5 ILE A 226
GLY A 242
VAL A 188
ALA A 245
SER A 205
 None
 1.22A 1nbhD-1vf8A:
undetectable		 1nbhD-1vf8A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhe AMINOPEPTIDASE/GLUCA
NASE HOMOLOG

(Bacillus
subtilis) 		PF05343
(Peptidase_M42) 		5 ILE A 240
GLY A 299
ALA A 304
SER A 302
HIS A  68
 None
None
None
None
ZN  A 372 (-3.5A)
 1.18A 1nbhD-1vheA:
undetectable		 1nbhD-1vheA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wls L-ASPARAGINASE

(Pyrococcus
horikoshii) 		PF00710
(Asparaginase) 		5 TYR A 168
ILE A 138
GLY A 322
HIS A 183
TYR A 139
 None
 1.11A 1nbhD-1wlsA:
undetectable		 1nbhD-1wlsA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x87 UROCANASE PROTEIN

(Geobacillus
stearothermophilus) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		5 ILE A 135
GLY A 436
VAL A 359
SER A 131
HIS A 439
 None
 1.35A 1nbhD-1x87A:
6.5		 1nbhD-1x87A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z3v CELLULASE

(Phanerochaete
chrysosporium) 		PF00840
(Glyco_hydro_7) 		5 TYR A 106
GLY A 167
ALA A 162
MET A 146
SER A  36
 None
 1.14A 1nbhD-1z3vA:
undetectable		 1nbhD-1z3vA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjy R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
brevis) 		PF13561
(adh_short_C2) 		5 TYR A 155
GLY A 145
ALA A 157
SER A 158
TYR A 189
 SS2  A1260 ( 4.2A)
None
None
None
None
 1.39A 1nbhD-1zjyA:
6.9		 1nbhD-1zjyA:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avn UBIQUINONE/MENAQUINO
NE BIOSYNTHESIS
METHYLTRANSFERASE-RE
LATED PROTEIN

(Thermotoga
maritima) 		PF08241
(Methyltransf_11) 		5 TYR A   9
GLY A  52
SER A  73
MET A  76
TYR A  20
 SAI  A1300 (-3.8A)
SAI  A1300 (-3.5A)
SAI  A1300 (-4.7A)
SAI  A1300 ( 4.2A)
None
 1.18A 1nbhD-2avnA:
19.5		 1nbhD-2avnA:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b6n PROTEINASE K

(Serratia sp.
GF96) 		PF00082
(Peptidase_S8) 		5 ILE A  10
GLY A  78
ALA A  53
SER A 211
HIS A  46
 None
 1.35A 1nbhD-2b6nA:
undetectable		 1nbhD-2b6nA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2buj SERINE/THREONINE-PRO
TEIN KINASE 16

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 132
GLY A 222
VAL A 224
SER A 271
MET A 272
 None
 1.31A 1nbhD-2bujA:
undetectable		 1nbhD-2bujA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		5 ILE A 640
GLY A 594
ALA A 573
SER A 574
SER A 556
 None
 1.39A 1nbhD-2cn3A:
undetectable		 1nbhD-2cn3A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dbn HYPOTHETICAL PROTEIN
YBIU

(Escherichia
coli) 		PF07350
(DUF1479) 		5 ILE A  90
ALA A 416
SER A 181
SER A 152
TYR A  66
 None
 1.24A 1nbhD-2dbnA:
undetectable		 1nbhD-2dbnA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2n HEXOKINASE

(Sulfurisphaera
tokodaii) 		PF01869
(BcrAD_BadFG) 		5 TYR A 145
ILE A 176
GLY A 148
VAL A 172
SER A 143
 None
 1.36A 1nbhD-2e2nA:
undetectable		 1nbhD-2e2nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		5 TYR A 130
ILE A 202
VAL A 194
SER A 129
HIS A 184
 None
 1.29A 1nbhD-2g18A:
undetectable		 1nbhD-2g18A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 212
VAL A 216
ALA A 208
SER A 444
HIS A 348
 None
None
6NA  A1460 (-3.4A)
NH4  A1461 ( 4.4A)
None
 1.34A 1nbhD-2iwzA:
undetectable		 1nbhD-2iwzA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 ILE A 482
SER A 422
MET A 428
TRP A 285
TYR A 483
 TPW  A1554 (-4.1A)
None
TPW  A1554 (-4.0A)
None
TPW  A1554 (-4.8A)
 1.09A 1nbhD-2ji9A:
3.2		 1nbhD-2ji9A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzx CANDIDAPEPSIN-5

(Candida
albicans) 		PF00026
(Asp) 		5 ILE A  18
GLY A  21
VAL A  99
ALA A  68
SER A  69
 None
 1.23A 1nbhD-2qzxA:
undetectable		 1nbhD-2qzxA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3al0 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermotoga
maritima) 		PF01425
(Amidase) 		5 ILE A 456
GLY A 436
VAL A 425
SER A 430
TRP A 132
 None
 1.38A 1nbhD-3al0A:
undetectable		 1nbhD-3al0A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awd PUTATIVE POLYOL
DEHYDROGENASE

(Gluconobacter
oxydans) 		PF13561
(adh_short_C2) 		5 TYR A 162
ILE A  22
GLY A 146
ALA A 167
SER A 165
 None
 1.21A 1nbhD-3awdA:
6.9		 1nbhD-3awdA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnj CHOLESTEROL OXIDASE

(Streptomyces
sp. SA-COO) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 TYR A  20
GLY A 114
VAL A  95
ALA A  23
SER A 227
 FAD  A 510 (-4.5A)
FAD  A 510 (-3.0A)
None
None
None
 1.08A 1nbhD-3cnjA:
2.5		 1nbhD-3cnjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cr7 ADENYLYL-SULFATE
KINASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase) 		5 GLY A  37
VAL A 140
ALA A  42
SER A  39
TYR A 172
 ADP  A2001 (-3.0A)
None
None
ADP  A2001 (-2.3A)
None
 1.36A 1nbhD-3cr7A:
undetectable		 1nbhD-3cr7A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dc8 DIHYDROPYRIMIDINASE

(Sinorhizobium
meliloti) 		PF01979
(Amidohydro_1) 		5 ILE A 222
GLY A 258
VAL A 256
ALA A 311
HIS A 236
 None
None
None
None
ZN  A 501 (-3.4A)
 1.39A 1nbhD-3dc8A:
undetectable		 1nbhD-3dc8A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		5 ILE A   9
GLY A 293
VAL A  18
ALA A 288
SER A  98
 None
 1.40A 1nbhD-3ddnA:
5.3		 1nbhD-3ddnA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dit PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		PF03166
(MH2) 		5 ILE A 426
GLY A 323
VAL A 286
SER A 341
TYR A 266
 None
 1.26A 1nbhD-3ditA:
undetectable		 1nbhD-3ditA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzu PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep)
PF00105
(zf-C4) 		5 TYR D 327
ILE D 472
VAL D 293
ALA D 331
TYR D 473
 None
 1.00A 1nbhD-3dzuD:
undetectable		 1nbhD-3dzuD:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fdd L-ASPARTATE-BETA-DEC
ARBOXYLASE

(Comamonas
testosteroni) 		PF00155
(Aminotran_1_2) 		5 GLY A 325
VAL A 327
ALA A 319
SER A 314
TYR A 180
 None
None
None
PLP  A 534 (-2.5A)
None
 1.38A 1nbhD-3fddA:
undetectable		 1nbhD-3fddA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fr8 PUTATIVE KETOL-ACID
REDUCTOISOMERASE
(OS05G0573700
PROTEIN)

(Oryza sativa) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 ILE A 360
GLY A 368
VAL A 372
ALA A 566
TYR A 468
 None
 1.38A 1nbhD-3fr8A:
3.8		 1nbhD-3fr8A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmj PROTEIN MOTHERS
AGAINST DPP

(Drosophila
melanogaster) 		no annotation 5 ILE D 426
GLY D 323
VAL D 286
SER D 341
TYR D 266
 None
 1.39A 1nbhD-3gmjD:
undetectable		 1nbhD-3gmjD:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0l GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Aquifex
aeolicus) 		PF01425
(Amidase) 		5 GLY A 170
VAL A 422
SER A 166
SER A 124
TYR A 303
 ASN  A 901 (-3.6A)
None
None
ASN  A 901 (-3.0A)
None
 1.21A 1nbhD-3h0lA:
undetectable		 1nbhD-3h0lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpf MUCONATE
CYCLOISOMERASE

(Oceanobacillus
iheyensis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A  11
TRP A 374
SER A  44
HIS A  45
TYR A 329
 None
None
None
MG  A 402 ( 3.4A)
None
 1.27A 1nbhD-3hpfA:
undetectable		 1nbhD-3hpfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icj UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE

(Pyrococcus
furiosus) 		PF07969
(Amidohydro_3) 		5 TYR A 221
ILE A 135
VAL A 112
ALA A 225
SER A 224
 None
 1.22A 1nbhD-3icjA:
undetectable		 1nbhD-3icjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2g RESINIFERATOXIN-BIND
ING,
PHOSPHOTRIESTERASE-R
ELATED PROTEIN

(Rhodobacter
sphaeroides) 		PF02126
(PTE) 		5 ILE A 151
GLY A 177
SER A 179
TRP A  42
SER A 138
 None
None
None
DTV  A 402 (-3.7A)
None
 1.29A 1nbhD-3k2gA:
undetectable		 1nbhD-3k2gA:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfu GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Thermus
thermophilus) 		PF01425
(Amidase) 		5 GLY E 164
VAL E 411
SER E 160
SER E 118
TYR E 295
 None
 1.18A 1nbhD-3kfuE:
undetectable		 1nbhD-3kfuE:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		5 TYR A 182
GLY A 227
VAL A 225
ALA A 230
SER A 229
 None
 1.40A 1nbhD-3la8A:
undetectable		 1nbhD-3la8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		5 ILE A  97
VAL A 128
ALA A 209
MET A 179
SER A 192
 None
None
None
None
UNL  A 301 ( 3.7A)
 1.33A 1nbhD-3ndoA:
2.5		 1nbhD-3ndoA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng3 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycobacterium
avium) 		PF01791
(DeoC) 		5 ILE A  95
VAL A 126
ALA A 207
MET A 177
SER A 190
 None
None
None
None
UNL  A 301 ( 3.6A)
 1.39A 1nbhD-3ng3A:
undetectable		 1nbhD-3ng3A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		5 ILE A 828
GLY A 790
VAL A 785
TRP A 201
HIS A 295
 None
 0.96A 1nbhD-3nzuA:
undetectable		 1nbhD-3nzuA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 ILE A 343
GLY A 254
VAL A 252
ALA A 257
SER A 256
 None
 1.05A 1nbhD-3pigA:
undetectable		 1nbhD-3pigA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3px2 N-METHYLTRANSFERASE

(Streptomyces
fradiae) 		PF13649
(Methyltransf_25) 		5 TYR A  14
GLY A  60
SER A  81
MET A  84
SER A 120
 SAH  A 263 ( 3.9A)
SAH  A 263 (-3.3A)
SAH  A 263 (-4.7A)
SAH  A 263 (-4.5A)
SAH  A 263 (-3.3A)
 0.69A 1nbhD-3px2A:
22.4		 1nbhD-3px2A:
25.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qt4 CATHEPSIN-L-LIKE
MIDGUT CYSTEINE
PROTEINASE

(Tenebrio
molitor) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 TYR A  73
ILE A 151
ALA A 235
SER A 280
TYR A 187
 PG6  A 419 ( 3.6A)
None
None
None
PG4  A 414 (-4.6A)
 1.15A 1nbhD-3qt4A:
undetectable		 1nbhD-3qt4A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r13 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Thermotoga
maritima) 		PF01791
(DeoC) 		5 ILE A 120
VAL A 151
ALA A 227
MET A 197
SER A 210
 None
None
None
None
UNL  A 300 ( 4.1A)
 1.37A 1nbhD-3r13A:
2.2		 1nbhD-3r13A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw5 TRANSGLUTAMINASE
ELICITOR

(Phytophthora
sojae) 		PF16683
(TGase_elicitor) 		5 ILE A 457
GLY A 201
ALA A 321
SER A 324
TRP A 215
 None
 1.35A 1nbhD-3tw5A:
undetectable		 1nbhD-3tw5A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v2g 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
REDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 TYR A 180
ILE A  43
GLY A 165
ALA A 185
SER A 183
 None
 1.22A 1nbhD-3v2gA:
7.1		 1nbhD-3v2gA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfa ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF10566
(Glyco_hydro_97)
PF14508
(GH97_N)
PF14509
(GH97_C) 		5 ILE A 603
GLY A 339
ALA A 342
MET A 334
TYR A 376
 None
 1.40A 1nbhD-3wfaA:
undetectable		 1nbhD-3wfaA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwn PUTATIVE
ACETYLGLUTAMATE
KINASE-LIKE PROTEIN

(Thermus
thermophilus) 		PF00696
(AA_kinase) 		5 ILE A 210
GLY A 195
VAL A 207
ALA A 251
SER A 191
 None
 1.26A 1nbhD-3wwnA:
undetectable		 1nbhD-3wwnA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a9a RIBOSOME-INTERACTING
GTPASE 1

(Saccharomyces
cerevisiae) 		PF01926
(MMR_HSR1)
PF02824
(TGS)
PF16897
(MMR_HSR1_Xtn) 		5 ILE A 122
GLY A  69
VAL A  71
ALA A  66
SER A  67
 None
 1.05A 1nbhD-4a9aA:
undetectable		 1nbhD-4a9aA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8j IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 ILE A 488
GLY A 435
ALA A 396
SER A 398
TYR A 492
 None
 1.38A 1nbhD-4b8jA:
undetectable		 1nbhD-4b8jA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		5 ILE A1727
GLY A1732
VAL A1730
ALA A1700
SER A1699
 None
 1.12A 1nbhD-4bpcA:
undetectable		 1nbhD-4bpcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A

(Oryza sativa) 		PF00514
(Arm)
PF16186
(Arm_3) 		5 ILE A 488
GLY A 435
ALA A 396
SER A 398
TYR A 492
 None
 1.38A 1nbhD-4bplA:
undetectable		 1nbhD-4bplA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4y SHORT CHAIN
DEHYDROGENASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF13561
(adh_short_C2) 		5 TYR A 137
ILE A 212
GLY A 123
VAL A 165
SER A 140
 GOL  A 306 (-4.8A)
None
None
None
None
 1.34A 1nbhD-4e4yA:
3.3		 1nbhD-4e4yA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 TYR A 151
ILE A  19
GLY A 137
ALA A 156
SER A 154
 None
 1.19A 1nbhD-4fgsA:
7.8		 1nbhD-4fgsA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz PROTEIN E6

(Alphapapillomavirus
9) 		PF00518
(E6) 		5 TYR C  81
TRP C 132
GLY C 130
SER C  80
TYR C  92
 None
 1.40A 1nbhD-4gizC:
undetectable		 1nbhD-4gizC:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6f SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 189
GLY A 267
VAL A 269
SER A 313
MET A 314
 None
 1.22A 1nbhD-4i6fA:
undetectable		 1nbhD-4i6fA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ine PROTEIN PMT-2

(Caenorhabditis
elegans) 		PF08241
(Methyltransf_11) 		5 TYR A 187
GLY A 234
SER A 256
MET A 259
HIS A 303
 SAH  A 501 ( 4.1A)
SAH  A 501 (-3.6A)
SAH  A 501 (-4.5A)
SAH  A 501 (-3.9A)
SAH  A 501 (-4.0A)
 0.62A 1nbhD-4ineA:
18.0		 1nbhD-4ineA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kri PHOSPHOLETHANOLAMINE
N-METHYLTRANSFERASE
2

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 TYR A 183
GLY A 230
SER A 252
MET A 255
HIS A 299
 SAH  A 701 ( 4.2A)
SAH  A 701 (-3.5A)
SAH  A 701 (-4.7A)
SAH  A 701 (-3.9A)
SAH  A 701 (-4.2A)
 0.68A 1nbhD-4kriA:
17.9		 1nbhD-4kriA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mou ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Paenarthrobacter
aurescens) 		PF00378
(ECH_1) 		5 ILE A 150
GLY A 155
ALA A 128
SER A 127
SER A  97
 None
 1.20A 1nbhD-4mouA:
undetectable		 1nbhD-4mouA:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6f PUTATIVE THIOSUGAR
SYNTHASE

(Amycolatopsis
orientalis) 		PF05690
(ThiG) 		5 ILE A 180
GLY A 195
VAL A 193
ALA A 169
SER A 170
 None
F6R  A 304 (-3.5A)
None
F6R  A 304 (-4.7A)
None
 1.23A 1nbhD-4n6fA:
undetectable		 1nbhD-4n6fA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p74 PHENYLALANINE--TRNA
LIGASE ALPHA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01409
(tRNA-synt_2d) 		5 ILE C  37
GLY C 228
VAL C 130
ALA C 176
MET C 202
 None
2U9  C 301 (-3.6A)
None
None
None
 1.19A 1nbhD-4p74C:
undetectable		 1nbhD-4p74C:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q80 SERINE PROTEASE 57

(Homo sapiens) 		PF00089
(Trypsin) 		5 ILE A  16
GLY A 197
VAL A 138
SER A  54
HIS A  57
 None
None
None
None
2YS  A 304 (-2.6A)
 1.22A 1nbhD-4q80A:
undetectable		 1nbhD-4q80A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		5 TYR A 156
GLY A 146
ALA A 158
SER A 159
TYR A 190
 None
 1.32A 1nbhD-4rf3A:
6.9		 1nbhD-4rf3A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkm NADH-DEPENDENT
REDUCTASE FOR
4-DEOXY-L-ERYTHRO-5-
HEXOSEULOSE URONATE

(Sphingomonas
sp. A1) 		PF13561
(adh_short_C2) 		5 TYR A 164
ILE A  19
GLY A 149
ALA A 169
SER A 167
 None
SO4  A 303 (-3.5A)
None
None
None
 1.25A 1nbhD-4tkmA:
6.7		 1nbhD-4tkmA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tkt AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ILE A3493
GLY A3201
SER A3198
TRP A3180
SER A3350
 None
 1.35A 1nbhD-4tktA:
undetectable		 1nbhD-4tktA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqt D-HYDANTOINASE

(Brucella suis) 		PF01979
(Amidohydro_1) 		5 ILE A 226
GLY A 262
VAL A 260
ALA A 315
HIS A 240
 None
None
None
None
ZN  A 502 (-3.5A)
 1.37A 1nbhD-4tqtA:
undetectable		 1nbhD-4tqtA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ILE A 222
ALA A 268
SER A 284
SER A 190
HIS A 189
 NA  A 410 ( 3.8A)
None
None
None
SO4  A 401 (-4.4A)
 1.37A 1nbhD-4tvoA:
6.1		 1nbhD-4tvoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvo L,D-TRANSPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF03734
(YkuD) 		5 ILE A 188
GLY A 161
ALA A 158
SER A 159
HIS A 216
 None
None
None
None
PO4  A 501 (-4.0A)
 1.32A 1nbhD-4xvoA:
undetectable		 1nbhD-4xvoA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		5 TRP A 376
GLY A 133
ALA A 365
SER A 366
HIS A 361
 None
None
None
None
BTB  A 505 (-4.4A)
 1.04A 1nbhD-4zg8A:
undetectable		 1nbhD-4zg8A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g ENDOLYSIN,CLAUDIN-4

(Homo sapiens;
Escherichia
virus T4) 		PF00822
(PMP22_Claudin)
PF00959
(Phage_lysozyme) 		5 TRP A1181
ILE A1251
GLY A1180
VAL A1184
ALA A1175
 None
 1.24A 1nbhD-5b2gA:
undetectable		 1nbhD-5b2gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by2 PHOSPHOHEPTOSE
ISOMERASE

(Colwellia
psychrerythraea) 		PF13580
(SIS_2) 		5 ILE A  86
GLY A  48
ALA A 141
SER A 122
TYR A  95
 None
 1.21A 1nbhD-5by2A:
2.4		 1nbhD-5by2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbt DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Streptococcus
suis) 		PF01791
(DeoC) 		5 ILE A  92
VAL A 123
ALA A 199
MET A 169
SER A 182
 None
 1.30A 1nbhD-5dbtA:
undetectable		 1nbhD-5dbtA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epo 7-ALPHA-HYDROXYSTERO
ID DEYDROGENASE

(Clostridium
sardiniense) 		PF13561
(adh_short_C2) 		5 ILE A 165
VAL A 121
ALA A  23
SER A  22
SER A  13
 None
None
None
None
NAP  A 301 (-3.0A)
 1.33A 1nbhD-5epoA:
3.5		 1nbhD-5epoA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fub PROTEIN ARGININE
METHYLTRANSFERASE 2

(Danio rerio) 		PF13649
(Methyltransf_25) 		5 TYR A  84
GLY A 125
VAL A 128
ALA A 147
SER A 148
 SAH  A 409 ( 3.6A)
SAH  A 409 ( 3.7A)
None
SAH  A 409 (-3.5A)
SAH  A 409 ( 4.2A)
 0.71A 1nbhD-5fubA:
8.5		 1nbhD-5fubA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 VAL B 850
ALA B 869
SER B 886
SER B 817
HIS B 779
 FMT  B4011 (-4.8A)
None
None
None
None
 1.40A 1nbhD-5gztB:
undetectable		 1nbhD-5gztB:
14.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		5 GLY A  69
SER A  90
MET A  93
TRP A 115
SER A 135
 SAH  A 301 (-3.3A)
SAH  A 301 ( 4.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.1A)
 0.64A 1nbhD-5h02A:
26.2		 1nbhD-5h02A:
30.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ipy FLAVIN-CONTAINING
MONOOXYGENASE

(Roseovarius
nubinhibens) 		PF00743
(FMO-like) 		5 TYR A 417
ILE A 370
GLY A  74
SER A  96
HIS A 404
 None
 1.19A 1nbhD-5ipyA:
2.1		 1nbhD-5ipyA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k6o B-GLUCOSIDASE

(metagenome) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 ILE A 656
GLY A 257
ALA A 230
SER A 238
TYR A 657
 None
 1.34A 1nbhD-5k6oA:
undetectable		 1nbhD-5k6oA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 ILE A 179
GLY A  76
VAL A  78
ALA A  73
TYR A 169
 None
 1.35A 1nbhD-5kshA:
undetectable		 1nbhD-5kshA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzm TRYPTOPHAN SYNTHASE
BETA CHAIN

(Francisella
tularensis) 		PF00291
(PALP) 		5 GLY B 231
VAL B 308
ALA B 301
SER B 300
SER B 296
 LLP  B  86 ( 3.7A)
None
None
None
CA  B 402 (-4.2A)
 1.38A 1nbhD-5kzmB:
undetectable		 1nbhD-5kzmB:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN S26
40S RIBOSOMAL
PROTEIN S3A-2

(Trypanosoma
cruzi;
Trypanosoma
cruzi) 		no annotation
no annotation 		5 TYR T  62
GLY T  65
ALA T  56
SER T  59
TYR W  83
 None
 1.25A 1nbhD-5optT:
undetectable		 1nbhD-5optT:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2w SHORT CHAIN
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 TYR A 155
ILE A  18
GLY A 140
ALA A 160
SER A 158
 IMD  A 304 ( 4.3A)
NAP  A 301 (-4.0A)
None
None
None
 1.21A 1nbhD-5u2wA:
5.9		 1nbhD-5u2wA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v12 HERCYNYLCYSTEINE
SULFOXIDE LYASE

(Neurospora
crassa) 		no annotation 5 GLY C 199
VAL C 194
ALA C 437
MET C 197
SER C 440
 None
None
None
FMT  C 501 ( 4.9A)
None
 1.31A 1nbhD-5v12C:
undetectable		 1nbhD-5v12C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 TYR A 246
GLY A 292
SER A 314
MET A 317
HIS A 360
 SAH  A 703 ( 4.0A)
SAH  A 703 ( 3.7A)
SAH  A 703 (-4.5A)
SAH  A 703 (-3.8A)
SAH  A 703 (-4.0A)
 0.82A 1nbhD-5wp4A:
17.2		 1nbhD-5wp4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 5 ILE A 694
GLY A 286
ALA A 259
SER A 267
TYR A 695
 None
 1.35A 1nbhD-5wugA:
undetectable		 1nbhD-5wugA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zbi PEPTIDE ASPARAGINYL
LIGASE

(Viola
canadensis) 		no annotation 5 ILE A  85
GLY A  78
VAL A  80
ALA A 317
TYR A  72
 None
 1.40A 1nbhD-5zbiA:
undetectable		 1nbhD-5zbiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 5 TRP F 169
ILE F 168
ALA F 236
SER F 238
TYR F 165
 None
 1.40A 1nbhD-6f0kF:
undetectable		 1nbhD-6f0kF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 5 GLY A 547
VAL A  29
ALA A 200
SER A 199
TRP A 215
 None
 1.33A 1nbhD-6fwfA:
undetectable		 1nbhD-6fwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1byr PROTEIN
(ENDONUCLEASE)

(Salmonella
enterica) 		PF13091
(PLDc_2) 		3 ARG A 152
ASP A  55
ASN A 102
 None
 0.92A 1nbhD-1byrA:
2.2		 1nbhD-1byrA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT

(Escherichia
coli) 		PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 ARG A 590
ASP A  57
ASN A  48
 None
 0.88A 1nbhD-1c30A:
2.1		 1nbhD-1c30A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgj ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
desulfuricans) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 ARG A 123
ASP A 805
ASN A 800
 None
 0.77A 1nbhD-1dgjA:
undetectable		 1nbhD-1dgjA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hww ALPHA-MANNOSIDASE II

(Drosophila
melanogaster) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		3 ARG A 304
ASP A 278
ASN A  67
 None
 0.94A 1nbhD-1hwwA:
0.2		 1nbhD-1hwwA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq3 GLYCEROL
DEHYDROGENASE

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 ARG A  74
ASP A  41
ASN A  48
 None
 0.95A 1nbhD-1kq3A:
2.2		 1nbhD-1kq3A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus) 		PF02247
(Como_LCP) 		3 ARG 2 240
ASP 2 321
ASN 2 270
 None
 0.87A 1nbhD-1pgw2:
undetectable		 1nbhD-1pgw2:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1px8 BETA-XYLOSIDASE

(Thermoanaerobacterium
saccharolyticum) 		PF01229
(Glyco_hydro_39) 		3 ARG A 260
ASP A 223
ASN A 192
 None
 0.88A 1nbhD-1px8A:
undetectable		 1nbhD-1px8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qaf PROTEIN (COPPER
AMINE OXIDASE)

(Escherichia
coli) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3)
PF07833
(Cu_amine_oxidN1) 		3 ARG A  92
ASP A 329
ASN A 327
 None
 0.83A 1nbhD-1qafA:
undetectable		 1nbhD-1qafA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcj POKEWEED ANTIVIRAL
PROTEIN

(Phytolacca
americana) 		PF00161
(RIP) 		3 ARG A 241
ASP A 248
ASN A 185
 None
 0.89A 1nbhD-1qcjA:
undetectable		 1nbhD-1qcjA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qrr SULFOLIPID
BIOSYNTHESIS (SQD1)
PROTEIN

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 ARG A 327
ASP A 231
ASN A 228
 UPG  A 402 (-2.7A)
None
None
 0.76A 1nbhD-1qrrA:
7.0		 1nbhD-1qrrA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		3 ARG A 375
ASP A 201
ASN A 100
 CL  A 601 (-3.1A)
PLP  A1227 (-2.7A)
None
 0.95A 1nbhD-1qz9A:
2.2		 1nbhD-1qz9A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP1)
HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP2)

(Rhinovirus A;
Rhinovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		3 ARG 2 165
ASP 1 198
ASN 2 219
 None
 0.94A 1nbhD-1r1a2:
undetectable		 1nbhD-1r1a2:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ARG A 659
ASP A 466
ASN A 468
 None
 0.82A 1nbhD-1r8wA:
undetectable		 1nbhD-1r8wA:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		3 ARG A 411
ASP A 292
ASN A 314
 None
 0.69A 1nbhD-1v5cA:
undetectable		 1nbhD-1v5cA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 227
ASP A 417
ASN A 401
 None
 0.81A 1nbhD-1xkhA:
undetectable		 1nbhD-1xkhA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xzw PURPLE ACID
PHOSPHATASE

(Ipomoea batatas) 		PF00149
(Metallophos)
PF14008
(Metallophos_C)
PF16656
(Pur_ac_phosph_N) 		3 ARG A 183
ASP A   8
ASN A   3
 None
 0.85A 1nbhD-1xzwA:
undetectable		 1nbhD-1xzwA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yw4 SUCCINYLGLUTAMATE
DESUCCINYLASE

(Chromobacterium
violaceum) 		PF04952
(AstE_AspA) 		3 ARG A 170
ASP A  47
ASN A 242
 None
 0.65A 1nbhD-1yw4A:
undetectable		 1nbhD-1yw4A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		3 ARG A 311
ASP A 228
ASN A 190
 None
 0.95A 1nbhD-1z68A:
undetectable		 1nbhD-1z68A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ARG A 351
ASP A 196
ASN A 202
 None
 0.92A 1nbhD-2akjA:
undetectable		 1nbhD-2akjA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atc ASPARTATE
CARBAMOYLTRANSFERASE
, CATALYTIC CHAIN

(Escherichia
coli) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 ARG A 113
ASP A  19
ASN A  21
 None
 0.84A 1nbhD-2atcA:
3.3		 1nbhD-2atcA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oz8 MLL7089 PROTEIN

(Mesorhizobium
japonicum) 		PF13378
(MR_MLE_C) 		3 ARG A  17
ASP A 194
ASN A 246
 None
 0.83A 1nbhD-2oz8A:
undetectable		 1nbhD-2oz8A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rmp MUCOROPEPSIN

(Rhizomucor
miehei) 		PF00026
(Asp) 		3 ARG A 230
ASP A 212
ASN A 140
 None
 0.95A 1nbhD-2rmpA:
undetectable		 1nbhD-2rmpA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		3 ARG A 643
ASP A 900
ASN A1027
 None
GOL  A1541 (-3.5A)
None
 0.92A 1nbhD-2x2iA:
undetectable		 1nbhD-2x2iA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CORE
LIGHT HARVESTING
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		3 ARG B 286
ASP B 313
ASN B 318
 None
 0.95A 1nbhD-3a0hB:
undetectable		 1nbhD-3a0hB:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a27 UNCHARACTERIZED
PROTEIN MJ1557

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		3 ARG A  89
ASP A 102
ASN A 155
 None
None
SAM  A 250 (-3.6A)
 0.89A 1nbhD-3a27A:
14.2		 1nbhD-3a27A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 ARG A 192
ASP A 106
ASN A 131
 None
 0.90A 1nbhD-3ak5A:
undetectable		 1nbhD-3ak5A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0h NITRITE REDUCTASE

(Nicotiana
tabacum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 ARG A 351
ASP A 196
ASN A 202
 None
 0.92A 1nbhD-3b0hA:
undetectable		 1nbhD-3b0hA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed4 ARYLSULFATASE

(Escherichia
coli) 		PF00884
(Sulfatase) 		3 ARG A 345
ASP A  51
ASN A 170
 None
NA  A 519 (-3.3A)
None
 0.86A 1nbhD-3ed4A:
undetectable		 1nbhD-3ed4A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		3 ARG A 123
ASP A 805
ASN A 800
 None
 0.80A 1nbhD-3fahA:
undetectable		 1nbhD-3fahA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 104
ASP A 524
ASN A 554
 None
 0.89A 1nbhD-3fhhA:
undetectable		 1nbhD-3fhhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		3 ARG A 387
ASP A 268
ASN A 215
 None
 0.86A 1nbhD-3grhA:
undetectable		 1nbhD-3grhA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5c PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR
VITAMIN K-DEPENDENT
PROTEIN Z

(Homo sapiens;
Homo sapiens) 		PF00079
(Serpin)
PF00008
(EGF)
PF00089
(Trypsin)
PF14670
(FXa_inhibition) 		3 ARG B  93
ASP A 238
ASN A 419
 None
 0.73A 1nbhD-3h5cB:
undetectable		 1nbhD-3h5cB:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbx GLUTAMATE
DECARBOXYLASE 1

(Arabidopsis
thaliana) 		PF00282
(Pyridoxal_deC) 		3 ARG A  29
ASP A  53
ASN A  59
 None
 0.89A 1nbhD-3hbxA:
undetectable		 1nbhD-3hbxA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhm NISH2 P85ALPHA

(Homo sapiens) 		PF00017
(SH2)
PF16454
(PI3K_P85_iSH2) 		3 ARG B 348
ASP B 578
ASN B 453
 None
 0.74A 1nbhD-3hhmB:
undetectable		 1nbhD-3hhmB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		3 ARG A 343
ASP A 115
ASN A 112
 None
 0.86A 1nbhD-3hjeA:
undetectable		 1nbhD-3hjeA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		3 ARG A 362
ASP A 197
ASN A 189
 None
 0.89A 1nbhD-3hjrA:
1.8		 1nbhD-3hjrA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		3 ARG A 311
ASP A 285
ASN A 253
 None
 0.70A 1nbhD-3hxwA:
undetectable		 1nbhD-3hxwA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j04 MYOSIN-11
MYOSIN LIGHT
POLYPEPTIDE 6

(Gallus gallus;
Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ)
PF01576
(Myosin_tail_1)
PF02736
(Myosin_N)
PF13405
(EF-hand_6) 		3 ARG A 731
ASP C  96
ASN C 139
 None
 0.90A 1nbhD-3j04A:
undetectable		 1nbhD-3j04A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		3 ARG A 406
ASP A  93
ASN A  61
 None
 0.85A 1nbhD-3j1cA:
undetectable		 1nbhD-3j1cA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		3 ARG X 795
ASP X 909
ASN X 903
 None
 0.70A 1nbhD-3jb9X:
undetectable		 1nbhD-3jb9X:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		3 ARG A 118
ASP A 131
ASN A 184
 None
 0.76A 1nbhD-3k6rA:
14.5		 1nbhD-3k6rA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llc PUTATIVE HYDROLASE

(Agrobacterium
vitis) 		PF12697
(Abhydrolase_6) 		3 ARG A  22
ASP A 100
ASN A 132
 None
None
EDO  A 273 (-4.1A)
 0.95A 1nbhD-3llcA:
undetectable		 1nbhD-3llcA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 ARG A 440
ASP A 301
ASN A 242
 None
None
SO4  A 582 (-3.7A)
 0.66A 1nbhD-3nyoA:
undetectable		 1nbhD-3nyoA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		3 ARG B 867
ASP B 492
ASN B 214
 None
 0.90A 1nbhD-3o8oB:
undetectable		 1nbhD-3o8oB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		3 ARG A  54
ASP A 136
ASN A 155
 None
 0.90A 1nbhD-3p9uA:
3.2		 1nbhD-3p9uA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pps LACCASE

(Thielavia
arenaria) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ARG A 344
ASP A  19
ASN A  16
 None
 0.92A 1nbhD-3ppsA:
undetectable		 1nbhD-3ppsA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ro2 G-PROTEIN-SIGNALING
MODULATOR 2
PEPTIDE OF NUCLEAR
MITOTIC APPARATUS
PROTEIN 1

(Mus musculus;
Homo sapiens) 		PF13176
(TPR_7)
PF13424
(TPR_12)
no annotation 		3 ARG A 221
ASP B2005
ASN B2008
 None
 0.89A 1nbhD-3ro2A:
undetectable		 1nbhD-3ro2A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D

(Drosophila
melanogaster) 		PF00102
(Y_phosphatase) 		3 ARG A 193
ASP A 128
ASN A  70
 None
 0.81A 1nbhD-3s3fA:
undetectable		 1nbhD-3s3fA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufg GLYCYL-TRNA
SYNTHETASE ALPHA
SUBUNIT

(Campylobacter
jejuni) 		PF02091
(tRNA-synt_2e) 		3 ARG A 261
ASP A  61
ASN A  67
 None
ATP  A 288 (-3.7A)
None
 0.65A 1nbhD-3ufgA:
undetectable		 1nbhD-3ufgA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzu OUTER MEMBRANE
PROTEIN

(Neisseria
meningitidis) 		PF00267
(Porin_1) 		3 ARG X  91
ASP X 104
ASN X 107
 None
ANP  X 401 (-4.0A)
None
 0.88A 1nbhD-3vzuX:
undetectable		 1nbhD-3vzuX:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjp HYDROGENASE
EXPRESSION/FORMATION
PROTEIN HYPE

(Thermococcus
kodakarensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 ARG A 236
ASP A  43
ASN A  83
 None
MG  A 404 ( 3.1A)
None
 0.75A 1nbhD-3wjpA:
undetectable		 1nbhD-3wjpA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxo CATALASE-PEROXIDASE

(Synechococcus
elongatus) 		PF00141
(peroxidase) 		3 ARG A 106
ASP A 573
ASN A 577
 None
 0.92A 1nbhD-3wxoA:
undetectable		 1nbhD-3wxoA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aie GLUCAN
1,6-ALPHA-GLUCOSIDAS
E

(Lactobacillus
acidophilus) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		3 ARG A 382
ASP A 272
ASN A 268
 None
 0.89A 1nbhD-4aieA:
undetectable		 1nbhD-4aieA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ajt PROTEIN Z-DEPENDENT
PROTEASE INHIBITOR

(Mus musculus) 		PF00079
(Serpin) 		3 ARG A  71
ASP A 263
ASN A 310
 None
 0.94A 1nbhD-4ajtA:
undetectable		 1nbhD-4ajtA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4awe ENDO-BETA-D-1,4-MANN
ANASE

(Neurospora
sitophila) 		PF00150
(Cellulase) 		3 ARG A 310
ASP A 359
ASN A 356
 None
CL  A1394 ( 4.5A)
None
 0.86A 1nbhD-4aweA:
undetectable		 1nbhD-4aweA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7p RALF

(Legionella
pneumophila) 		PF01369
(Sec7) 		3 ARG A 293
ASP A  60
ASN A  69
 None
 0.93A 1nbhD-4c7pA:
undetectable		 1nbhD-4c7pA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eay MANNONATE
DEHYDRATASE

(Escherichia
coli) 		PF03786
(UxuA) 		3 ARG A 239
ASP A 320
ASN A 318
 None
 0.90A 1nbhD-4eayA:
undetectable		 1nbhD-4eayA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4epa PESTICIN RECEPTOR

(Yersinia pestis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 176
ASP A 192
ASN A 185
 None
 0.76A 1nbhD-4epaA:
undetectable		 1nbhD-4epaA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4h GLUTAMINE DEPENDENT
NAD+ SYNTHETASE

(Burkholderia
thailandensis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		3 ARG A 530
ASP A 500
ASN A  99
 None
 0.79A 1nbhD-4f4hA:
undetectable		 1nbhD-4f4hA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		3 ARG W 723
ASP W 632
ASN W 604
 None
 0.94A 1nbhD-4f5xW:
undetectable		 1nbhD-4f5xW:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		3 ARG A  10
ASP A  59
ASN A  88
 None
LLP  A  58 ( 4.7A)
LLP  A  58 (-3.9A)
 0.78A 1nbhD-4il5A:
2.4		 1nbhD-4il5A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l87 SERINE--TRNA LIGASE,
CYTOPLASMIC

(Homo sapiens) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 ARG A 317
ASP A 378
ASN A 363
 PO4  A 502 ( 3.8A)
MG  A 503 (-3.9A)
None
 0.95A 1nbhD-4l87A:
undetectable		 1nbhD-4l87A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4le4 BETA-GLUCANASE

(Podospora
anserina) 		no annotation 3 ARG A 131
ASP A 241
ASN A  63
 None
 0.82A 1nbhD-4le4A:
undetectable		 1nbhD-4le4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		3 ARG A 968
ASP A 853
ASN A 920
 CME  A 974 ( 4.3A)
None
None
 0.81A 1nbhD-4lglA:
2.9		 1nbhD-4lglA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16842
(RRM_occluded) 		3 ARG A  38
ASP A 321
ASN A 353
 G  B  50 ( 3.6A)
A  B  51 ( 3.4A)
None
 0.92A 1nbhD-4n0tA:
undetectable		 1nbhD-4n0tA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnb G PROTEIN-COUPLED
RECEPTOR KINASE 5

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		3 ARG A 388
ASP A 270
ASN A 267
 None
SGV  A 601 (-4.2A)
None
 0.89A 1nbhD-4tnbA:
undetectable		 1nbhD-4tnbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		3 ARG A 501
ASP A 330
ASN A 422
 None
 0.81A 1nbhD-4uhiA:
undetectable		 1nbhD-4uhiA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xee NEUROTENSIN RECEPTOR
TYPE 1, ENDOLYSIN
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ARG A 299
ASP A1010
ASN A1144
 None
 0.95A 1nbhD-4xeeA:
undetectable		 1nbhD-4xeeA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz7 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
suis) 		PF01841
(Transglut_core) 		3 ARG A 173
ASP A 127
ASN A 101
 None
 0.94A 1nbhD-4xz7A:
undetectable		 1nbhD-4xz7A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a01 O-GLYCOSYLTRANSFERAS
E

(Drosophila
melanogaster) 		PF13374
(TPR_10)
PF13414
(TPR_11)
PF13844
(Glyco_transf_41) 		3 ARG A 530
ASP A 459
ASN A 454
 None
 0.89A 1nbhD-5a01A:
3.1		 1nbhD-5a01A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp9 PUTATIVE
METHYLTRANSFERASE
PROTEIN

(Bacteroides
fragilis) 		PF13489
(Methyltransf_23) 		3 ARG A  64
ASP A 109
ASN A 130
 SAH  A 303 (-3.1A)
SAH  A 303 (-2.7A)
SAH  A 303 (-3.0A)
 0.33A 1nbhD-5bp9A:
14.1		 1nbhD-5bp9A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bq9 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF12252
(SidE) 		3 ARG A 373
ASP A 351
ASN A 347
 None
 0.85A 1nbhD-5bq9A:
undetectable		 1nbhD-5bq9A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu1 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 ARG A 373
ASP A 351
ASN A 347
 None
 0.80A 1nbhD-5bu1A:
undetectable		 1nbhD-5bu1A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu2 LPG1496

(Legionella
pneumophila) 		PF12252
(SidE) 		3 ARG A 373
ASP A 351
ASN A 347
 None
 0.95A 1nbhD-5bu2A:
undetectable		 1nbhD-5bu2A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2i ALR1585 PROTEIN

(Nostoc sp. PCC
7120) 		PF04261
(Dyp_perox) 		3 ARG A 121
ASP A 242
ASN A 246
 None
 0.90A 1nbhD-5c2iA:
undetectable		 1nbhD-5c2iA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d04 PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		3 ARG C 349
ASP C 286
ASN C 272
 None
 0.94A 1nbhD-5d04C:
undetectable		 1nbhD-5d04C:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyn PUTATIVE PEPTIDASE
PUTATIVE PEPTIDASE

(Bacteroides
fragilis;
Bacteroides
fragilis) 		PF03415
(Peptidase_C11)
PF03415
(Peptidase_C11) 		3 ARG A  81
ASP B 152
ASN B 154
 None
NA  A 401 (-2.3A)
None
 0.92A 1nbhD-5dynA:
undetectable		 1nbhD-5dynA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 3 ARG C 491
ASP C  26
ASN C  32
 None
 0.81A 1nbhD-5elpC:
undetectable		 1nbhD-5elpC:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f5w GLYCINE--TRNA LIGASE
ALPHA SUBUNIT

(Aquifex
aeolicus) 		PF02091
(tRNA-synt_2e) 		3 ARG A 257
ASP A  61
ASN A  67
 None
G5A  A 300 (-3.9A)
None
 0.80A 1nbhD-5f5wA:
undetectable		 1nbhD-5f5wA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fbu PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N) 		3 ARG A 666
ASP A 391
ASN A 752
 5WP  A 901 (-2.8A)
None
None
 0.88A 1nbhD-5fbuA:
undetectable		 1nbhD-5fbuA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 3 ARG A 132
ASP A 175
ASN A 228
 None
None
GOL  A1346 (-4.1A)
 0.81A 1nbhD-5fzpA:
3.2		 1nbhD-5fzpA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvf CARBOXYPEPTIDASE B2
VHH-I83

(Homo sapiens;
Vicugna pacos) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
PF07686
(V-set) 		3 ARG B  70
ASP B 100
ASN A 328
 None
 0.88A 1nbhD-5hvfB:
undetectable		 1nbhD-5hvfB:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihe DNA POLYMERASE II
SMALL SUBUNIT

(Pyrococcus
abyssi) 		PF00149
(Metallophos) 		3 ARG A 570
ASP A 304
ASN A 332
 None
 0.87A 1nbhD-5iheA:
undetectable		 1nbhD-5iheA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		3 ARG A 758
ASP A 641
ASN A 631
 None
 0.89A 1nbhD-5kd5A:
undetectable		 1nbhD-5kd5A:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		3 ARG A 326
ASP A 300
ASN A 257
 None
 0.78A 1nbhD-5knnA:
undetectable		 1nbhD-5knnA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei) 		PF00141
(peroxidase) 		3 ARG A 123
ASP A 599
ASN A 603
 None
 0.92A 1nbhD-5kqiA:
undetectable		 1nbhD-5kqiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lcw CELL DIVISION CYCLE
PROTEIN 20 HOMOLOG
MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA,MITOTIC
CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1
BETA

(Homo sapiens;
Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40)
PF08311
(Mad3_BUB1_I) 		3 ARG S  36
ASP Q 184
ASN Q 188
 None
 0.73A 1nbhD-5lcwS:
undetectable		 1nbhD-5lcwS:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN8

(Saccharomyces
cerevisiae) 		PF01398
(JAB)
PF13012
(MitMem_reg) 		3 ARG U 254
ASP U 243
ASN U 238
 None
 0.71A 1nbhD-5mpdU:
undetectable		 1nbhD-5mpdU:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 3 ARG A 688
ASP A 654
ASN A 751
 None
 0.66A 1nbhD-5n94A:
4.8		 1nbhD-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63) 		PF01600
(Corona_S1)
PF01601
(Corona_S2) 		3 ARG A 530
ASP A 393
ASN A 240
 None
NAG  A1405 ( 4.8A)
NAG  A1404 ( 1.8A)
 0.92A 1nbhD-5szsA:
undetectable		 1nbhD-5szsA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf0 GLYCOSYL HYDROLASE
FAMILY 3 N-TERMINAL
DOMAIN PROTEIN

(Bacteroides
intestinalis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 ARG A 708
ASP A 178
ASN A 175
 None
 0.94A 1nbhD-5tf0A:
undetectable		 1nbhD-5tf0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tg8 HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ARG A  91
ASP A 298
ASN A 296
 None
 0.62A 1nbhD-5tg8A:
undetectable		 1nbhD-5tg8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5una 7SK SNRNA
METHYLPHOSPHATE
CAPPING ENZYME

(Homo sapiens) 		PF06859
(Bin3)
PF13847
(Methyltransf_31) 		3 ARG A 433
ASP A 474
ASN A 559
 SAH  A 701 (-3.1A)
SAH  A 701 (-2.8A)
SAH  A 701 (-3.6A)
 0.73A 1nbhD-5unaA:
14.2		 1nbhD-5unaA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uq6 TARTRATE-RESISTANT
ACID PHOSPHATASE
TYPE 5

(Sus scrofa) 		PF00149
(Metallophos) 		3 ARG A 157
ASP A  52
ASN A 243
 None
FE  A 403 ( 2.7A)
None
 0.94A 1nbhD-5uq6A:
undetectable		 1nbhD-5uq6A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz9 CRISPR-ASSOCIATED
PROTEIN CSY1
CRISPR-ASSOCIATED
PROTEIN CSY2

(Pseudomonas
aeruginosa;
Pseudomonas
aeruginosa) 		PF09611
(Cas_Csy1)
PF09614
(Cas_Csy2) 		3 ARG A 321
ASP B 215
ASN A 237
 None
 0.93A 1nbhD-5uz9A:
undetectable		 1nbhD-5uz9A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy8 INTERLEUKIN-1
RECEPTOR ACCESSORY
PROTEIN-LIKE 1

(Homo sapiens) 		no annotation 3 ARG B 106
ASP B 101
ASN B  63
 None
None
NAG  B 403 (-1.9A)
 0.51A 1nbhD-5wy8B:
undetectable		 1nbhD-5wy8B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 3 ARG A 270
ASP A 256
ASN A 215
 None
 0.87A 1nbhD-5x3jA:
undetectable		 1nbhD-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwb 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Colwellia
psychrerythraea) 		PF00275
(EPSP_synthase) 		3 ARG A 387
ASP A  49
ASN A  51
 None
 0.95A 1nbhD-5xwbA:
undetectable		 1nbhD-5xwbA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 3 ARG A 375
ASP A 165
ASN A 134
 None
 0.90A 1nbhD-5yj6A:
undetectable		 1nbhD-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blj SERINE-TRNA LIGASE

(Naegleria
fowleri) 		no annotation 3 ARG A 321
ASP A 382
ASN A 367
 None
 0.78A 1nbhD-6bljA:
undetectable		 1nbhD-6bljA:
undetectable