SIMILAR PATTERNS OF AMINO ACIDS FOR 1NBH_C_SAMC2293
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a4i | METHYLENETETRAHYDROFOLATE DEHYDROGENASE/METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (Homo sapiens) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ILE A 238GLY A 274VAL A 271ASP A 235SER A 13 | NDP A 302 (-4.4A)NoneNoneNoneNone | 1.04A | 1nbhC-1a4iA:4.4 | 1nbhC-1a4iA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1coy | CHOLESTEROL OXIDASE (Brevibacteriumsterolicum) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | TYR A 21GLY A 114VAL A 95ALA A 24SER A 227 | FAD A 510 (-4.4A)FAD A 510 (-3.0A)NoneNoneNone | 1.12A | 1nbhC-1coyA:undetectable | 1nbhC-1coyA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e3h | GUANOSINEPENTAPHOSPHATESYNTHETASE (Streptomycesantibioticus) |
PF00013(KH_1)PF01138(RNase_PH)PF03726(PNPase) | 5 | ILE A 198GLY A 158VAL A 186ALA A 141SER A 142 | None | 1.32A | 1nbhC-1e3hA:0.2 | 1nbhC-1e3hA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gpe | PROTEIN (GLUCOSEOXIDASE) (Penicilliumamagasakiense) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ILE A 555GLY A 534VAL A 536ASP A 537ALA A 395 | NoneNoneNoneNoneNAG A 604 (-3.4A) | 1.27A | 1nbhC-1gpeA:1.8 | 1nbhC-1gpeA:17.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1htr | GASTRICSINPROGASTRICSIN (PROSEGMENT) (Homo sapiens;Homo sapiens) |
PF00026(Asp)PF07966(A1_Propeptide) | 5 | ILE B 180GLY B 170VAL B 315ALA P 1TYR B 176 | None | 1.29A | 1nbhC-1htrB:undetectable | 1nbhC-1htrB:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2b | ARCHAEOSINETRNA-GUANINETRANSGLYCOSYLASE (Pyrococcushorikoshii) |
PF01472(PUA)PF01702(TGT)PF14809(TGT_C1)PF14810(TGT_C2) | 5 | GLY A 126VAL A 123ASP A 124ALA A 166HIS A 227 | None | 1.23A | 1nbhC-1j2bA:0.5 | 1nbhC-1j2bA:17.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j6y | PEPTIDYL-PROLYLCIS-TRANS ISOMERASE (Arabidopsisthaliana) |
PF00639(Rotamase) | 5 | VAL A 113ASP A 108ALA A 10SER A 11SER A 104 | None | 1.00A | 1nbhC-1j6yA:undetectable | 1nbhC-1j6yA:18.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khu | SMAD1 (Homo sapiens) |
PF03166(MH2) | 5 | ILE A 436GLY A 333VAL A 296SER A 351TYR A 276 | None | 1.34A | 1nbhC-1khuA:undetectable | 1nbhC-1khuA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l2q | MONOMETHYLAMINEMETHYLTRANSFERASE (Methanosarcinabarkeri) |
PF05369(MtmB) | 5 | ILE A 135GLY A 129VAL A 143SER A 365SER A 369 | NoneNoneNoneXPL A 202 ( 2.7A)None | 0.97A | 1nbhC-1l2qA:0.6 | 1nbhC-1l2qA:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pug | HYPOTHETICAL UPF0133PROTEIN YBAB (Escherichiacoli) |
PF02575(YbaB_DNA_bd) | 5 | ILE A 84GLY A 35VAL A 33ALA A 39SER A 37 | None | 1.27A | 1nbhC-1pugA:undetectable | 1nbhC-1pugA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qax | PROTEIN(3-HYDROXY-3-METHYLGLUTARYL-COENZYME AREDUCTASE) (Pseudomonasmevalonii) |
PF00368(HMG-CoA_red) | 5 | TYR A 92ILE A 248GLY A 367ALA A 88MET A 93 | HMG A1002 (-4.0A)NoneHMG A1002 (-4.5A)HMG A1002 (-3.6A)None | 1.22A | 1nbhC-1qaxA:undetectable | 1nbhC-1qaxA:21.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qle | CYTOCHROME C OXIDASEPOLYPEPTIDE I-BETA (Paracoccusdenitrificans) |
PF00115(COX1) | 5 | ILE A 226GLY A 286ALA A 426SER A 291HIS A 292 | None | 1.20A | 1nbhC-1qleA:undetectable | 1nbhC-1qleA:19.74 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r8y | GLYCINEN-METHYLTRANSFERASE (Mus musculus) |
PF13847(Methyltransf_31) | 7 | GLY A 66VAL A 69ALA A 86SER A 87MET A 90TRP A 117HIS A 142 | None | 0.65A | 1nbhC-1r8yA:35.0 | 1nbhC-1r8yA:95.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1r8y | GLYCINEN-METHYLTRANSFERASE (Mus musculus) |
PF13847(Methyltransf_31) | 8 | GLY A 66VAL A 69ASP A 70ALA A 86SER A 87MET A 90TRP A 117SER A 139 | None | 0.57A | 1nbhC-1r8yA:35.0 | 1nbhC-1r8yA:95.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sde | D-ALANYL-D-ALANINECARBOXYPEPTIDASE (Streptomycessp. R61) |
PF00144(Beta-lactamase) | 5 | ILE A 141GLY A 168VAL A 166ALA A 180HIS A 200 | None | 1.18A | 1nbhC-1sdeA:undetectable | 1nbhC-1sdeA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ua7 | ALPHA-AMYLASE (Bacillussubtilis) |
PF00128(Alpha-amylase) | 5 | TYR A 220ILE A 100GLY A 207ASP A 97MET A 224 | None | 1.27A | 1nbhC-1ua7A:undetectable | 1nbhC-1ua7A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uzn | 3-OXOACYL-[ACYL-CARRIER PROTEIN]REDUCTASE (Mycobacteriumtuberculosis) |
PF13561(adh_short_C2) | 5 | TYR A 153ILE A 27GLY A 139ALA A 158SER A 156 | NoneNAP A1249 (-4.1A)NoneNoneNone | 1.15A | 1nbhC-1uznA:5.8 | 1nbhC-1uznA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ve3 | HYPOTHETICAL PROTEINPH0226 (Pyrococcushorikoshii) |
PF13649(Methyltransf_25) | 5 | GLY A 48SER A 69MET A 72SER A 112HIS A 115 | SAM A 302 (-3.6A)SAM A 302 (-4.7A)SAM A 302 (-3.9A)SAM A 302 (-3.3A)SAM A 302 (-3.8A) | 0.72A | 1nbhC-1ve3A:20.0 | 1nbhC-1ve3A:25.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vf8 | SECRETORY PROTEIN (Mus musculus) |
PF00704(Glyco_hydro_18) | 5 | ILE A 226GLY A 242VAL A 188ALA A 245SER A 205 | None | 1.21A | 1nbhC-1vf8A:undetectable | 1nbhC-1vf8A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhe | AMINOPEPTIDASE/GLUCANASE HOMOLOG (Bacillussubtilis) |
PF05343(Peptidase_M42) | 5 | ILE A 240GLY A 299ALA A 304SER A 302HIS A 68 | NoneNoneNoneNone ZN A 372 (-3.5A) | 1.18A | 1nbhC-1vheA:undetectable | 1nbhC-1vheA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wls | L-ASPARAGINASE (Pyrococcushorikoshii) |
PF00710(Asparaginase) | 5 | TYR A 168ILE A 138GLY A 322HIS A 183TYR A 139 | None | 1.13A | 1nbhC-1wlsA:undetectable | 1nbhC-1wlsA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yw1 | PROTEIN YTNJ (Bacillussubtilis) |
PF00296(Bac_luciferase) | 5 | TYR A 149ILE A 234VAL A 251ASP A 250HIS A 145 | FMN A2606 (-4.0A)NoneNoneNoneFMN A2606 (-4.2A) | 1.32A | 1nbhC-1yw1A:undetectable | 1nbhC-1yw1A:20.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3v | CELLULASE (Phanerochaetechrysosporium) |
PF00840(Glyco_hydro_7) | 5 | TYR A 106GLY A 167ALA A 162MET A 146SER A 36 | None | 1.14A | 1nbhC-1z3vA:undetectable | 1nbhC-1z3vA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b6n | PROTEINASE K (Serratia sp.GF96) |
PF00082(Peptidase_S8) | 5 | ILE A 10GLY A 78ALA A 53SER A 211HIS A 46 | None | 1.35A | 1nbhC-2b6nA:undetectable | 1nbhC-2b6nA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2buj | SERINE/THREONINE-PROTEIN KINASE 16 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 132GLY A 222VAL A 224SER A 271MET A 272 | None | 1.31A | 1nbhC-2bujA:undetectable | 1nbhC-2bujA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dbn | HYPOTHETICAL PROTEINYBIU (Escherichiacoli) |
PF07350(DUF1479) | 5 | ILE A 90ALA A 416SER A 181SER A 152TYR A 66 | None | 1.25A | 1nbhC-2dbnA:undetectable | 1nbhC-2dbnA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g18 | PHYCOCYANOBILIN:FERREDOXINOXIDOREDUCTASE (Anabaena sp.) |
PF05996(Fe_bilin_red) | 5 | TYR A 130ILE A 202VAL A 194SER A 129HIS A 184 | None | 1.30A | 1nbhC-2g18A:undetectable | 1nbhC-2g18A:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iwz | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE (Homo sapiens) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | GLY A 212VAL A 216ALA A 208SER A 444HIS A 348 | NoneNone6NA A1460 (-3.4A)NH4 A1461 ( 4.4A)None | 1.33A | 1nbhC-2iwzA:undetectable | 1nbhC-2iwzA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ji9 | OXALYL-COADECARBOXYLASE (Oxalobacterformigenes) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 482SER A 422MET A 428TRP A 285TYR A 483 | TPW A1554 (-4.1A)NoneTPW A1554 (-4.0A)NoneTPW A1554 (-4.8A) | 1.09A | 1nbhC-2ji9A:3.2 | 1nbhC-2ji9A:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nqi | CALPAIN-1 CATALYTICSUBUNIT (Rattusnorvegicus) |
PF00648(Peptidase_C2) | 5 | ILE A 238GLY A 249ALA A 213SER A 211SER A 123 | None | 1.26A | 1nbhC-2nqiA:undetectable | 1nbhC-2nqiA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ovl | PUTATIVE RACEMASE (Streptomycescoelicolor) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 109VAL A 273ASP A 272HIS A 326TYR A 49 | None | 1.19A | 1nbhC-2ovlA:undetectable | 1nbhC-2ovlA:24.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q1f | CHONDROITINASE (Bacteroidesthetaiotaomicron) |
PF02278(Lyase_8)PF09092(Lyase_N)PF09093(Lyase_catalyt) | 5 | TYR A 630GLY A 698VAL A 693ASP A 694HIS A 454 | None | 1.29A | 1nbhC-2q1fA:undetectable | 1nbhC-2q1fA:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfr | PURPLE ACIDPHOSPHATASE (Phaseolusvulgaris) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 5 | TYR A 379VAL A 324ASP A 369ALA A 381SER A 330 | None | 1.35A | 1nbhC-2qfrA:undetectable | 1nbhC-2qfrA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzx | CANDIDAPEPSIN-5 (Candidaalbicans) |
PF00026(Asp) | 5 | ILE A 18GLY A 21VAL A 99ALA A 68SER A 69 | None | 1.24A | 1nbhC-2qzxA:undetectable | 1nbhC-2qzxA:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vz9 | FATTY ACID SYNTHASE (Sus scrofa) |
PF00107(ADH_zinc_N)PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF08242(Methyltransf_12)PF08659(KR)PF14765(PS-DH)PF16197(KAsynt_C_assoc) | 5 | GLY A 330VAL A 33ASP A 31ALA A 340SER A 336 | None | 1.34A | 1nbhC-2vz9A:undetectable | 1nbhC-2vz9A:8.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wb1 | DNA-DIRECTED RNAPOLYMERASE RPO4SUBUNIT (Sulfolobusshibatae) |
PF03874(RNA_pol_Rpb4) | 5 | ILE F 86VAL F 68ASP F 67ALA F 17SER F 15 | None | 1.33A | 1nbhC-2wb1F:undetectable | 1nbhC-2wb1F:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3awd | PUTATIVE POLYOLDEHYDROGENASE (Gluconobacteroxydans) |
PF13561(adh_short_C2) | 5 | TYR A 162ILE A 22GLY A 146ALA A 167SER A 165 | None | 1.21A | 1nbhC-3awdA:6.4 | 1nbhC-3awdA:24.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cnj | CHOLESTEROL OXIDASE (Streptomycessp. SA-COO) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | TYR A 20GLY A 114VAL A 95ALA A 23SER A 227 | FAD A 510 (-4.5A)FAD A 510 (-3.0A)NoneNoneNone | 1.10A | 1nbhC-3cnjA:undetectable | 1nbhC-3cnjA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dit | PROTEIN MOTHERSAGAINST DPP (Drosophilamelanogaster) |
PF03166(MH2) | 5 | ILE A 426GLY A 323VAL A 286SER A 341TYR A 266 | None | 1.26A | 1nbhC-3ditA:undetectable | 1nbhC-3ditA:21.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzu | PEROXISOMEPROLIFERATOR-ACTIVATED RECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep)PF00105(zf-C4) | 5 | TYR D 327ILE D 472VAL D 293ALA D 331TYR D 473 | None | 1.01A | 1nbhC-3dzuD:undetectable | 1nbhC-3dzuD:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdf | PROBABLENADP-DEPENDENTMANNITOLDEHYDROGENASE (Cladosporiumherbarum) |
PF13561(adh_short_C2) | 5 | TYR A 175ILE A 157GLY A 163ASP A 257ALA A 166 | None | 1.32A | 1nbhC-3gdfA:6.6 | 1nbhC-3gdfA:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gkb | PUTATIVE ENOYL-COAHYDRATASE (Streptomycesavermitilis) |
PF00378(ECH_1) | 5 | TYR A 199ILE A 207VAL A 106ASP A 127ALA A 131 | None | 1.28A | 1nbhC-3gkbA:undetectable | 1nbhC-3gkbA:23.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h0l | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Aquifexaeolicus) |
PF01425(Amidase) | 5 | GLY A 170VAL A 422SER A 166SER A 124TYR A 303 | ASN A 901 (-3.6A)NoneNoneASN A 901 (-3.0A)None | 1.21A | 1nbhC-3h0lA:undetectable | 1nbhC-3h0lA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpf | MUCONATECYCLOISOMERASE (Oceanobacillusiheyensis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 11TRP A 374SER A 44HIS A 45TYR A 329 | NoneNoneNone MG A 402 ( 3.4A)None | 1.26A | 1nbhC-3hpfA:undetectable | 1nbhC-3hpfA:20.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3icj | UNCHARACTERIZEDMETAL-DEPENDENTHYDROLASE (Pyrococcusfuriosus) |
PF07969(Amidohydro_3) | 5 | TYR A 221ILE A 135VAL A 112ALA A 225SER A 224 | None | 1.21A | 1nbhC-3icjA:undetectable | 1nbhC-3icjA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jv7 | ADH-A (Rhodococcusruber) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | ILE A 28GLY A 66VAL A 68ASP A 82ALA A 149 | None | 1.32A | 1nbhC-3jv7A:6.8 | 1nbhC-3jv7A:22.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2g | RESINIFERATOXIN-BINDING,PHOSPHOTRIESTERASE-RELATED PROTEIN (Rhodobactersphaeroides) |
PF02126(PTE) | 5 | ILE A 151GLY A 177SER A 179TRP A 42SER A 138 | NoneNoneNoneDTV A 402 (-3.7A)None | 1.29A | 1nbhC-3k2gA:undetectable | 1nbhC-3k2gA:25.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kfu | GLUTAMYL-TRNA(GLN)AMIDOTRANSFERASESUBUNIT A (Thermusthermophilus) |
PF01425(Amidase) | 5 | GLY E 164VAL E 411SER E 160SER E 118TYR E 295 | None | 1.18A | 1nbhC-3kfuE:undetectable | 1nbhC-3kfuE:21.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l07 | BIFUNCTIONAL PROTEINFOLD (Francisellatularensis) |
PF00763(THF_DHG_CYH)PF02882(THF_DHG_CYH_C) | 5 | ILE A 231GLY A 260VAL A 257ASP A 228SER A 10 | IMD A 503 ( 4.6A)NoneNoneNoneNone | 1.20A | 1nbhC-3l07A:undetectable | 1nbhC-3l07A:21.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ndo | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Mycolicibacteriumsmegmatis) |
PF01791(DeoC) | 5 | ILE A 97VAL A 128ALA A 209MET A 179SER A 192 | NoneNoneNoneNoneUNL A 301 ( 3.7A) | 1.33A | 1nbhC-3ndoA:2.5 | 1nbhC-3ndoA:25.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nvs | 3-PHOSPHOSHIKIMATE1-CARBOXYVINYLTRANSFERASE (Vibrio cholerae) |
PF00275(EPSP_synthase) | 5 | ILE A 126VAL A 130ASP A 131ALA A 181SER A 180 | None | 1.19A | 1nbhC-3nvsA:undetectable | 1nbhC-3nvsA:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nzu | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT GAMMAISOFORM (Homo sapiens) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 5 | ILE A 828GLY A 790VAL A 785TRP A 201HIS A 295 | None | 0.97A | 1nbhC-3nzuA:2.3 | 1nbhC-3nzuA:15.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ocr | CLASS IIALDOLASE/ADDUCINDOMAIN PROTEIN (Pseudomonassavastanoi) |
PF00596(Aldolase_II) | 5 | ILE A 102VAL A 87ASP A 88ALA A 116TYR A 104 | None | 1.17A | 1nbhC-3ocrA:undetectable | 1nbhC-3ocrA:19.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pig | BETA-FRUCTOFURANOSIDASE (Bifidobacteriumlongum) |
PF00251(Glyco_hydro_32N)PF08244(Glyco_hydro_32C) | 5 | ILE A 343GLY A 254VAL A 252ALA A 257SER A 256 | None | 1.06A | 1nbhC-3pigA:undetectable | 1nbhC-3pigA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3px2 | N-METHYLTRANSFERASE (Streptomycesfradiae) |
PF13649(Methyltransf_25) | 5 | TYR A 14GLY A 60SER A 81MET A 84SER A 120 | SAH A 263 ( 3.9A)SAH A 263 (-3.3A)SAH A 263 (-4.7A)SAH A 263 (-4.5A)SAH A 263 (-3.3A) | 0.68A | 1nbhC-3px2A:22.3 | 1nbhC-3px2A:25.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qt4 | CATHEPSIN-L-LIKEMIDGUT CYSTEINEPROTEINASE (Tenebriomolitor) |
PF00112(Peptidase_C1)PF08246(Inhibitor_I29) | 5 | GLY A 161ASP A 152ALA A 79SER A 124TYR A 187 | NoneNonePG4 A 413 (-3.6A)NonePG4 A 414 (-4.6A) | 1.20A | 1nbhC-3qt4A:undetectable | 1nbhC-3qt4A:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rd5 | MYPAA.01249.C (Mycobacteriumavium) |
PF00106(adh_short) | 5 | GLY A 111ASP A 104ALA A 169SER A 166HIS A 117 | None | 1.06A | 1nbhC-3rd5A:6.5 | 1nbhC-3rd5A:21.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3to3 | PETROBACTINBIOSYNTHESIS PROTEINASBB (Bacillusanthracis) |
PF04183(IucA_IucC)PF06276(FhuF) | 5 | ILE A 252GLY A 364VAL A 243ALA A 316TYR A 256 | None | 1.26A | 1nbhC-3to3A:undetectable | 1nbhC-3to3A:18.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uwd | PHOSPHOGLYCERATEKINASE (Bacillusanthracis) |
PF00162(PGK) | 5 | ILE A 302VAL A 264ASP A 265ALA A 228TYR A 303 | None | 1.31A | 1nbhC-3uwdA:undetectable | 1nbhC-3uwdA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v2g | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | TYR A 180ILE A 43GLY A 165ALA A 185SER A 183 | None | 1.22A | 1nbhC-3v2gA:6.5 | 1nbhC-3v2gA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wwn | PUTATIVEACETYLGLUTAMATEKINASE-LIKE PROTEIN (Thermusthermophilus) |
PF00696(AA_kinase) | 5 | ILE A 210GLY A 195VAL A 207ALA A 251SER A 191 | None | 1.27A | 1nbhC-3wwnA:undetectable | 1nbhC-3wwnA:23.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wyh | LYSOZYME G (Struthiocamelus) |
PF01464(SLT) | 5 | TYR A 169VAL A 8ASP A 62ALA A 146SER A 145 | TAM A 201 ( 4.5A)NoneNoneNoneNone | 1.30A | 1nbhC-3wyhA:undetectable | 1nbhC-3wyhA:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a9a | RIBOSOME-INTERACTINGGTPASE 1 (Saccharomycescerevisiae) |
PF01926(MMR_HSR1)PF02824(TGS)PF16897(MMR_HSR1_Xtn) | 5 | ILE A 122GLY A 69VAL A 71ALA A 66SER A 67 | None | 1.05A | 1nbhC-4a9aA:undetectable | 1nbhC-4a9aA:23.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bpc | RECEPTOR-TYPETYROSINE-PROTEINPHOSPHATASE S (Homo sapiens) |
PF00102(Y_phosphatase) | 5 | ILE A1727GLY A1732VAL A1730ALA A1700SER A1699 | None | 1.11A | 1nbhC-4bpcA:undetectable | 1nbhC-4bpcA:19.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4y | SHORT CHAINDEHYDROGENASE FAMILYPROTEIN (Francisellatularensis) |
PF13561(adh_short_C2) | 5 | TYR A 137ILE A 212GLY A 123VAL A 165SER A 140 | GOL A 306 (-4.8A)NoneNoneNoneNone | 1.33A | 1nbhC-4e4yA:undetectable | 1nbhC-4e4yA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fgs | PROBABLEDEHYDROGENASEPROTEIN (Rhizobium etli) |
PF13561(adh_short_C2) | 5 | TYR A 151ILE A 19GLY A 137ALA A 156SER A 154 | None | 1.18A | 1nbhC-4fgsA:7.5 | 1nbhC-4fgsA:23.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i6f | SERINE/THREONINE-PROTEIN KINASE PLK2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 189GLY A 267VAL A 269SER A 313MET A 314 | None | 1.21A | 1nbhC-4i6fA:undetectable | 1nbhC-4i6fA:21.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ine | PROTEIN PMT-2 (Caenorhabditiselegans) |
PF08241(Methyltransf_11) | 5 | TYR A 187GLY A 234SER A 256MET A 259HIS A 303 | SAH A 501 ( 4.1A)SAH A 501 (-3.6A)SAH A 501 (-4.5A)SAH A 501 (-3.9A)SAH A 501 (-4.0A) | 0.61A | 1nbhC-4ineA:17.9 | 1nbhC-4ineA:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4it1 | PUTATIVE GLUCARATEDEHYDRATASE (Pseudomonasfluorescens) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 367VAL A 372SER A 318SER A 321HIS A 320 | None | 1.35A | 1nbhC-4it1A:undetectable | 1nbhC-4it1A:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iw7 | 8-AMINO-7-OXONONANOATE SYNTHASE (Francisellatularensis) |
PF00155(Aminotran_1_2) | 5 | ILE A 103VAL A 215ASP A 185ALA A 175TYR A 104 | None | 1.21A | 1nbhC-4iw7A:undetectable | 1nbhC-4iw7A:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jd0 | NUCLEOTIDYLTRANSFERASE (Thermotogamaritima) |
PF00483(NTP_transferase) | 5 | ILE A 152GLY A 156VAL A 145ASP A 166SER A 190 | NonePO4 A 306 (-3.4A)None1KH A 301 ( 2.6A) NA A 312 ( 2.8A) | 1.24A | 1nbhC-4jd0A:undetectable | 1nbhC-4jd0A:24.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kri | PHOSPHOLETHANOLAMINEN-METHYLTRANSFERASE2 (Haemonchuscontortus) |
PF08241(Methyltransf_11) | 5 | TYR A 183GLY A 230SER A 252MET A 255HIS A 299 | SAH A 701 ( 4.2A)SAH A 701 (-3.5A)SAH A 701 (-4.7A)SAH A 701 (-3.9A)SAH A 701 (-4.2A) | 0.67A | 1nbhC-4kriA:18.3 | 1nbhC-4kriA:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lrs | 4-HYDROXY-2-OXOVALERATE ALDOLASE (Thermomonosporacurvata) |
PF00682(HMGL-like)PF07836(DmpG_comm) | 5 | ILE A 195GLY A 166ASP A 164ALA A 132SER A 126 | None | 1.31A | 1nbhC-4lrsA:undetectable | 1nbhC-4lrsA:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mf9 | HEMIN DEGRADINGFACTOR (Pseudomonasaeruginosa) |
PF05171(HemS) | 5 | GLY A 42VAL A 144ASP A 140ALA A 174SER A 47 | None | 1.11A | 1nbhC-4mf9A:undetectable | 1nbhC-4mf9A:24.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mou | ENOYL-COAHYDRATASE/ISOMERASEFAMILY PROTEIN (Paenarthrobacteraurescens) |
PF00378(ECH_1) | 5 | ILE A 150GLY A 155ALA A 128SER A 127SER A 97 | None | 1.20A | 1nbhC-4mouA:undetectable | 1nbhC-4mouA:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mup | AMIDOHYDROLASE (Agrobacteriumfabrum) |
PF04909(Amidohydro_2) | 5 | ILE A 181GLY A 175ASP A 151ALA A 205SER A 210 | None | 1.35A | 1nbhC-4mupA:undetectable | 1nbhC-4mupA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6f | PUTATIVE THIOSUGARSYNTHASE (Amycolatopsisorientalis) |
PF05690(ThiG) | 5 | ILE A 180GLY A 195VAL A 193ALA A 169SER A 170 | NoneF6R A 304 (-3.5A)NoneF6R A 304 (-4.7A)None | 1.23A | 1nbhC-4n6fA:undetectable | 1nbhC-4n6fA:23.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p74 | PHENYLALANINE--TRNALIGASE ALPHA SUBUNIT (Pseudomonasaeruginosa) |
PF01409(tRNA-synt_2d) | 5 | ILE C 37GLY C 228VAL C 130ALA C 176MET C 202 | None2U9 C 301 (-3.6A)NoneNoneNone | 1.20A | 1nbhC-4p74C:undetectable | 1nbhC-4p74C:19.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pdx | PUTATIVEALKYL/ARYL-SULFATASEYJCS (Escherichiacoli) |
PF00753(Lactamase_B)PF14863(Alkyl_sulf_dimr)PF14864(Alkyl_sulf_C) | 5 | VAL A 152ASP A 132ALA A 309HIS A 317TYR A 234 | NoneNoneNoneSO4 A 701 (-4.3A)None | 1.08A | 1nbhC-4pdxA:undetectable | 1nbhC-4pdxA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q80 | SERINE PROTEASE 57 (Homo sapiens) |
PF00089(Trypsin) | 5 | ILE A 16GLY A 197VAL A 138SER A 54HIS A 57 | NoneNoneNoneNone2YS A 304 (-2.6A) | 1.23A | 1nbhC-4q80A:undetectable | 1nbhC-4q80A:24.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rf3 | NADPH DEPENDENTR-SPECIFIC ALCOHOLDEHYDROGENASE (Lactobacilluskefiri) |
PF13561(adh_short_C2) | 5 | TYR A 156GLY A 146ALA A 158SER A 159TYR A 190 | None | 1.33A | 1nbhC-4rf3A:6.4 | 1nbhC-4rf3A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tkm | NADH-DEPENDENTREDUCTASE FOR4-DEOXY-L-ERYTHRO-5-HEXOSEULOSE URONATE (Sphingomonassp. A1) |
PF13561(adh_short_C2) | 5 | TYR A 164ILE A 19GLY A 149ALA A 169SER A 167 | NoneSO4 A 303 (-3.5A)NoneNoneNone | 1.24A | 1nbhC-4tkmA:6.8 | 1nbhC-4tkmA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xvo | L,D-TRANSPEPTIDASE (Mycolicibacteriumsmegmatis) |
PF03734(YkuD) | 5 | ILE A 188GLY A 161ALA A 158SER A 159HIS A 216 | NoneNoneNoneNonePO4 A 501 (-4.0A) | 1.32A | 1nbhC-4xvoA:undetectable | 1nbhC-4xvoA:22.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3g | PROTEIN SHORT-ROOT (Arabidopsisthaliana) |
PF03514(GRAS) | 5 | ILE B 513GLY B 238VAL B 490TRP B 269TYR B 482 | None | 1.26A | 1nbhC-5b3gB:9.1 | 1nbhC-5b3gB:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dbt | DEOXYRIBOSE-PHOSPHATE ALDOLASE (Streptococcussuis) |
PF01791(DeoC) | 5 | ILE A 92VAL A 123ALA A 199MET A 169SER A 182 | None | 1.31A | 1nbhC-5dbtA:undetectable | 1nbhC-5dbtA:25.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5epo | 7-ALPHA-HYDROXYSTEROID DEYDROGENASE (Clostridiumsardiniense) |
PF13561(adh_short_C2) | 5 | ILE A 165VAL A 121ALA A 23SER A 22SER A 13 | NoneNoneNoneNoneNAP A 301 (-3.0A) | 1.34A | 1nbhC-5epoA:6.7 | 1nbhC-5epoA:24.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fub | PROTEIN ARGININEMETHYLTRANSFERASE 2 (Danio rerio) |
PF13649(Methyltransf_25) | 5 | TYR A 84GLY A 125VAL A 128ALA A 147SER A 148 | SAH A 409 ( 3.6A)SAH A 409 ( 3.7A)NoneSAH A 409 (-3.5A)SAH A 409 ( 4.2A) | 0.72A | 1nbhC-5fubA:8.2 | 1nbhC-5fubA:23.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5h02 | GLYCINE SARCOSINEN-METHYLTRANSFERASE (Methanohalophilusportucalensis) |
PF13649(Methyltransf_25) | 5 | GLY A 69SER A 90MET A 93TRP A 115SER A 135 | SAH A 301 (-3.3A)SAH A 301 ( 4.9A)SAH A 301 (-3.9A)SAH A 301 (-3.6A)SAH A 301 (-3.1A) | 0.67A | 1nbhC-5h02A:26.2 | 1nbhC-5h02A:30.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ipy | FLAVIN-CONTAININGMONOOXYGENASE (Roseovariusnubinhibens) |
PF00743(FMO-like) | 5 | TYR A 417ILE A 370GLY A 74SER A 96HIS A 404 | None | 1.19A | 1nbhC-5ipyA:undetectable | 1nbhC-5ipyA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k6o | B-GLUCOSIDASE (metagenome) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | ILE A 656GLY A 257ALA A 230SER A 238TYR A 657 | None | 1.34A | 1nbhC-5k6oA:undetectable | 1nbhC-5k6oA:15.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ksh | PENICILLIN-BINDINGPROTEIN 2 (Neisseriagonorrhoeae) |
PF00905(Transpeptidase)PF03717(PBP_dimer) | 5 | ILE A 179GLY A 76VAL A 78ALA A 73TYR A 169 | None | 1.34A | 1nbhC-5kshA:undetectable | 1nbhC-5kshA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lx0 | DIPEPTIDASE (Aspergillusfumigatus) |
PF01244(Peptidase_M19) | 5 | ILE A 38VAL A 97ASP A 96ALA A 112SER A 129 | None | 1.23A | 1nbhC-5lx0A:undetectable | 1nbhC-5lx0A:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nit | GLUCOSE OXIDASE (Aspergillusniger) |
no annotation | 5 | ILE A 551GLY A 530VAL A 532ASP A 533ALA A 391 | NoneNoneNoneNoneNAG A 609 (-3.5A) | 1.34A | 1nbhC-5nitA:undetectable | 1nbhC-5nitA:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opt | 40S RIBOSOMALPROTEIN S2640S RIBOSOMALPROTEIN S3A-2 (Trypanosomacruzi;Trypanosomacruzi) |
no annotationno annotation | 5 | TYR T 62GLY T 65ALA T 56SER T 59TYR W 83 | None | 1.25A | 1nbhC-5optT:undetectable | 1nbhC-5optT:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u2w | SHORT CHAINDEHYDROGENASE (Burkholderiacenocepacia) |
PF00106(adh_short) | 5 | TYR A 155ILE A 18GLY A 140ALA A 160SER A 158 | IMD A 304 ( 4.3A)NAP A 301 (-4.0A)NoneNoneNone | 1.21A | 1nbhC-5u2wA:5.9 | 1nbhC-5u2wA:21.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5v12 | HERCYNYLCYSTEINESULFOXIDE LYASE (Neurosporacrassa) |
no annotation | 5 | GLY C 199VAL C 194ALA C 437MET C 197SER C 440 | NoneNoneNoneFMT C 501 ( 4.9A)None | 1.31A | 1nbhC-5v12C:undetectable | 1nbhC-5v12C:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vl1 | LYSINE--TRNA LIGASE (Mycobacteriumulcerans) |
PF00152(tRNA-synt_2)PF01336(tRNA_anti-codon) | 5 | TYR A 116ILE A 43GLY A 119VAL A 121ASP A 58 | None | 1.10A | 1nbhC-5vl1A:undetectable | 1nbhC-5vl1A:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wp4 | PHOSPHOETHANOLAMINEN-METHYLTRANSFERASE1 (Arabidopsisthaliana) |
no annotation | 5 | TYR A 246GLY A 292SER A 314MET A 317HIS A 360 | SAH A 703 ( 4.0A)SAH A 703 ( 3.7A)SAH A 703 (-4.5A)SAH A 703 (-3.8A)SAH A 703 (-4.0A) | 0.81A | 1nbhC-5wp4A:17.4 | 1nbhC-5wp4A:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wug | BETA-GLUCOSIDASE (Paenibacillusbarengoltzii) |
no annotation | 5 | ILE A 694GLY A 286ALA A 259SER A 267TYR A 695 | None | 1.35A | 1nbhC-5wugA:undetectable | 1nbhC-5wugA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fwf | NITRIC-OXIDEREDUCTASE (Neisseriameningitidis) |
no annotation | 5 | GLY A 547VAL A 29ALA A 200SER A 199TRP A 215 | None | 1.33A | 1nbhC-6fwfA:undetectable | 1nbhC-6fwfA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wti | CRISPR-ASSOCIATEDPROTEIN (Bacillusthermoamylovorans) |
no annotation | 4 | TRP Z 850ARG Z 791ASP Z 574ASN Z 954 | NoneNone MG Z1202 (-2.3A)None | 1.49A | 1nbhC-5wtiZ:1.8 | 1nbhC-5wtiZ:13.74 |