SIMILAR PATTERNS OF AMINO ACIDS FOR 1NBH_B_SAMB1293_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 TRP A 439
ARG A 433
ASN A 406
SER A 336
 None
 1.39A 1nbhB-1b41A:
2.0		 1nbhB-1b41A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wst MULTIPLE SUBSTRATE
AMINOTRANSFERASE

(Thermococcus
profundus) 		PF00155
(Aminotran_1_2) 		4 TRP A 265
ASP A 222
ASN A 194
SER A 226
 None
PLP  A 418 (-2.9A)
PLP  A 418 (-3.7A)
None
 1.07A 1nbhB-1wstA:
0.5		 1nbhB-1wstA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojh UNCHARACTERIZED
PROTEIN
ATU1656/AGR_C_3050

(Agrobacterium
fabrum) 		PF07676
(PD40) 		4 ARG A 147
ASP A  87
ASN A  57
SER A 108
 None
 1.23A 1nbhB-2ojhA:
0.9		 1nbhB-2ojhA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Homo sapiens) 		PF00012
(HSP70) 		4 ARG A 261
ASP A 250
ASN A 248
SER A 337
 None
 1.14A 1nbhB-3ldoA:
1.2		 1nbhB-3ldoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmk NUCLEOCAPSID PROTEIN

(Recombinant
vesicular
stomatitis
Indiana virus
rVSV-G/GFP) 		PF00945
(Rhabdo_ncap) 		4 ARG A 309
ASP A 392
ASN A 367
SER A 340
 None
 1.32A 1nbhB-3pmkA:
0.0		 1nbhB-3pmkA:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fe2 PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Streptococcus
pneumoniae) 		PF01259
(SAICAR_synt) 		4 ARG A 214
ASP A 191
ASN A  80
SER A 194
 AIR  A 301 (-3.1A)
ADP  A 302 ( 3.9A)
None
None
 1.48A 1nbhB-4fe2A:
0.0		 1nbhB-4fe2A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxb UREIDOGLYCOLATE
HYDROLASE

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20) 		4 ARG A 353
ASP A 425
ASN A 118
SER A 191
 UGC  A 503 (-2.8A)
None
None
None
 1.41A 1nbhB-4pxbA:
0.0		 1nbhB-4pxbA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wti CRISPR-ASSOCIATED
PROTEIN

(Bacillus
thermoamylovorans) 		no annotation 4 TRP Z 850
ARG Z 791
ASP Z 574
ASN Z 954
 None
None
MG  Z1202 (-2.3A)
None
 1.47A 1nbhB-5wtiZ:
1.8		 1nbhB-5wtiZ:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xwy A TYPE VI-A
CRISPR-CAS
RNA-GUIDED RNA
RIBONUCLEASE, CAS13A

(Leptotrichia
buccalis) 		no annotation 4 ARG A 185
ASP A1044
ASN A1070
SER A1076
 None
 1.26A 1nbhB-5xwyA:
0.0		 1nbhB-5xwyA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c93 CYTOCHROME P450 4B1

(Oryctolagus
cuniculus) 		no annotation 4 TRP A 163
ASP A 174
ASN A 491
SER A 320
 None
 1.42A 1nbhB-6c93A:
undetectable		 1nbhB-6c93A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 4 ARG A 261
ASP A 250
ASN A 248
SER A 337
 None
 1.29A 1nbhB-6eoeA:
0.9		 1nbhB-6eoeA:
21.69