SIMILAR PATTERNS OF AMINO ACIDS FOR 1NB9_A_RBFA401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iug PUTATIVE ASPARTATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		5 THR A 134
SER A  87
GLU A 131
ARG A 103
ASP A 105
 None
 1.49A 1nb9A-1iugA:
undetectable		 1nb9A-1iugA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n07 PUTATIVE RIBOFLAVIN
KINASE

(Schizosaccharomyces
pombe) 		PF01687
(Flavokinase) 		8 THR A  45
VAL A  79
SER A  81
GLU A  96
ARG A 121
LEU A 132
ILE A 136
ASP A 139
 FMN  A 165 (-4.4A)
FMN  A 165 ( 4.3A)
FMN  A 165 (-3.6A)
FMN  A 165 ( 2.8A)
FMN  A 165 (-2.9A)
FMN  A 165 (-4.5A)
FMN  A 165 ( 4.4A)
FMN  A 165 (-4.7A)
 0.83A 1nb9A-1n07A:
22.3		 1nb9A-1n07A:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p15 PROTEIN-TYROSINE
PHOSPHATASE ALPHA

(Mus musculus) 		PF00102
(Y_phosphatase) 		5 THR A 544
ILE A 569
VAL A 581
ARG A 611
ASP A 608
 None
 1.47A 1nb9A-1p15A:
undetectable		 1nb9A-1p15A:
21.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p4m RIBOFLAVIN KINASE

(Homo sapiens) 		PF01687
(Flavokinase) 		9 THR A  34
ILE A  53
VAL A  69
SER A  71
GLU A  86
ARG A 111
LEU A 122
ILE A 126
ASP A 129
 MG  A 201 (-3.2A)
FMN  A 401 (-3.9A)
FMN  A 401 (-4.6A)
FMN  A 401 ( 4.0A)
FMN  A 401 (-2.9A)
FMN  A 401 (-2.6A)
FMN  A 401 ( 4.7A)
FMN  A 401 ( 4.3A)
FMN  A 401 (-4.4A)
 0.17A 1nb9A-1p4mA:
30.2		 1nb9A-1p4mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t6x RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		7 THR A 180
VAL A 213
GLU A 231
ARG A 255
LEU A 266
ILE A 270
ASP A 273
 ADP  A 294 (-3.7A)
None
None
None
None
None
None
 0.86A 1nb9A-1t6xA:
8.4		 1nb9A-1t6xA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Thermotoga
maritima) 		PF01634
(HisG) 		5 ILE E 169
SER E  86
GLU E 150
LEU E  11
ASP E  66
 None
None
PO4  E1202 (-4.6A)
None
None
 1.01A 1nb9A-1usyE:
undetectable		 1nb9A-1usyE:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		5 VAL A 479
ARG A 122
LEU A  83
ILE A 183
ASP A 129
 None
 1.38A 1nb9A-1uxtA:
undetectable		 1nb9A-1uxtA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		5 THR A 419
ILE A  22
VAL A 355
ARG A  24
ASP A 351
 None
 1.35A 1nb9A-1v4gA:
0.0		 1nb9A-1v4gA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wer P120GAP

(Homo sapiens) 		PF00616
(RasGAP) 		5 GLU A1000
ARG A 758
LEU A 751
ILE A 755
ASP A 994
 None
 1.45A 1nb9A-1werA:
undetectable		 1nb9A-1werA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		5 ILE A 397
VAL A 388
ARG A 289
LEU A 424
ILE A 258
 None
 1.30A 1nb9A-2euhA:
undetectable		 1nb9A-2euhA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o20 CATABOLITE CONTROL
PROTEIN A

(Lactococcus
lactis) 		PF00532
(Peripla_BP_1) 		5 THR A 331
ILE A 183
VAL A 244
SER A 242
GLU A 270
 None
 1.19A 1nb9A-2o20A:
undetectable		 1nb9A-2o20A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk1 NOVP

(Actinoalloteichus
cyanogriseus) 		PF05711
(TylF) 		5 ILE A 221
VAL A 192
GLU A  92
LEU A  71
ILE A  74
 None
None
SAH  A 301 (-2.9A)
None
None
 1.06A 1nb9A-2wk1A:
undetectable		 1nb9A-2wk1A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		5 ILE A  98
SER A 101
GLU A 105
ARG A 241
ASP A 278
 None
 1.37A 1nb9A-2yrfA:
undetectable		 1nb9A-2yrfA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bnw RIBOFLAVIN KINASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01687
(Flavokinase) 		5 SER A  77
GLU A  92
ARG A 117
LEU A 128
ASP A 135
 None
 0.83A 1nb9A-3bnwA:
17.0		 1nb9A-3bnwA:
27.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 THR A 371
VAL A  17
LEU A 362
ILE A 338
ASP A 337
 None
 1.21A 1nb9A-3fcpA:
undetectable		 1nb9A-3fcpA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcy XYLAN ESTERASE 1

(Thermoanaerobacterium
saccharolyticum) 		PF05448
(AXE1) 		5 ILE A  69
SER A 123
LEU A 150
ILE A 154
ASP A 157
 None
 1.19A 1nb9A-3fcyA:
undetectable		 1nb9A-3fcyA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 SER A  59
ARG A  38
LEU A  45
ILE A  53
ASP A 257
 SAM  A4633 ( 4.9A)
SO4  A 268 (-3.9A)
None
None
None
 1.35A 1nb9A-3gczA:
undetectable		 1nb9A-3gczA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 THR A 118
ARG A  38
LEU A  45
ILE A  53
ASP A 257
 None
SO4  A 268 (-3.9A)
None
None
None
 1.14A 1nb9A-3gczA:
undetectable		 1nb9A-3gczA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j7y ICT1

(Homo sapiens) 		PF00861
(Ribosomal_L18p) 		5 THR p 122
ILE p 158
VAL p 115
GLU p 160
LEU p 135
 None
 1.50A 1nb9A-3j7yp:
undetectable		 1nb9A-3j7yp:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op1 MACROLIDE-EFFLUX
PROTEIN

(Streptococcus
pneumoniae) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 THR A 207
SER A 240
ARG A 279
LEU A 290
ASP A 297
 None
 0.94A 1nb9A-3op1A:
13.2		 1nb9A-3op1A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qeq DMF4 ALPHA CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		5 ILE D  79
VAL D 106
SER D  81
LEU D  60
ILE D  75
 None
 1.21A 1nb9A-3qeqD:
undetectable		 1nb9A-3qeqD:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnk PUTATIVE LIPOPROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ILE A  55
VAL A  57
GLU A 145
LEU A 211
ILE A 412
 None
 1.32A 1nb9A-3qnkA:
undetectable		 1nb9A-3qnkA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 ILE A 455
VAL A 296
ARG A 304
LEU A 406
ASP A 302
 None
 1.26A 1nb9A-4f7aA:
undetectable		 1nb9A-4f7aA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		5 THR A 432
ILE A 455
VAL A 296
ARG A 304
ASP A 302
 None
 1.16A 1nb9A-4f7aA:
undetectable		 1nb9A-4f7aA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 THR A 262
VAL A 303
GLU A 254
ARG A 244
ILE A 310
 None
 1.33A 1nb9A-4lbwA:
1.3		 1nb9A-4lbwA:
16.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		5 SER A 253
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 FMN  A 339 (-3.4A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
 0.97A 1nb9A-5a89A:
14.5		 1nb9A-5a89A:
32.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a89 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase) 		5 THR A 208
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 FMN  A 339 (-3.2A)
FMN  A 339 (-3.2A)
FMN  A 339 (-2.9A)
FMN  A 339 (-4.9A)
FMN  A 339 (-4.4A)
 0.80A 1nb9A-5a89A:
14.5		 1nb9A-5a89A:
32.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa5 NIFE-HYDROGENASE
LARGE SUBUNIT, HOFG
NIFE-HYDROGENASE
SMALL SUBUNIT, HOFK

(Cupriavidus
necator) 		PF00374
(NiFeSe_Hases)
PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		5 THR A  40
ILE C  83
LEU C 131
ILE C 126
ASP C 123
 None
 1.21A 1nb9A-5aa5A:
undetectable		 1nb9A-5aa5A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 THR A 686
ILE A 787
VAL A 508
LEU A 791
ILE A 387
 None
 1.33A 1nb9A-5ehkA:
undetectable		 1nb9A-5ehkA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyf GLUTAMATE ABC
SUPERFAMILY ATP
BINDING CASSETTE
TRANSPORTER, BINDING
PROTEIN

(Enterococcus
faecium) 		PF00497
(SBP_bac_3) 		5 ILE A  33
ARG A  36
LEU A  80
ILE A  43
ASP A 106
 None
 1.34A 1nb9A-5eyfA:
undetectable		 1nb9A-5eyfA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 SER A 253
GLU A 268
ARG A 292
LEU A 303
ASP A 310
 None
 0.85A 1nb9A-5fo1A:
14.2		 1nb9A-5fo1A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5had PROTEIN ACCUMULATION
AND REPLICATION OF
CHLOROPLASTS 6,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13355
(DUF4101) 		5 THR A 780
ILE A 682
VAL A 752
LEU A 707
ILE A 793
 EDO  A 901 ( 4.5A)
None
None
None
None
 1.38A 1nb9A-5hadA:
undetectable		 1nb9A-5hadA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7u MAJOR CAPSID PROTEIN

(Faustovirus) 		PF04451
(Capsid_NCLDV) 		5 THR A  79
ILE A 325
VAL A 323
SER A  86
ILE A 391
 None
 1.25A 1nb9A-5j7uA:
undetectable		 1nb9A-5j7uA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
ALPHA TYPE-7

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 ILE C  40
ARG C 212
LEU C 220
ILE C 188
ASP C 184
 None
 1.40A 1nb9A-5m32C:
undetectable		 1nb9A-5m32C:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE TLDD

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		5 THR A 174
ILE A 166
ARG A 180
ILE A 311
ASP A 178
 None
 1.11A 1nb9A-5njfA:
undetectable		 1nb9A-5njfA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 5 ILE A 232
VAL A 228
LEU A 300
ILE A 168
ASP A 164
 None
 1.27A 1nb9A-5xoiA:
undetectable		 1nb9A-5xoiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ba5 VARIABLE DOMAIN OF
LIGHT CHAIN,
ANTIBODY R11

(Homo sapiens) 		no annotation 5 THR A  12
VAL A 110
LEU A  74
ILE A  76
ASP A  83
 None
 1.44A 1nb9A-6ba5A:
undetectable		 1nb9A-6ba5A:
20.16