SIMILAR PATTERNS OF AMINO ACIDS FOR 1N6C_A_SAMA402_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bf2 | ISOAMYLASE (Pseudomonasamyloderamosa) |
PF00128(Alpha-amylase)PF02922(CBM_48) | 5 | GLY A 188GLU A 191ASN A 232HIS A 509GLU A 183 | NoneNone CA A 751 (-3.0A)NoneNone | 1.50A | 1n6cA-1bf2A:undetectable | 1n6cA-1bf2A:18.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1br2 | MYOSIN (Gallus gallus) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | ILE A 686ALA A 181GLY A 182GLU A 185ASN A 236 | NoneADP A 998 ( 4.5A)ADP A 998 (-3.3A)ADP A 998 (-4.7A)None | 1.07A | 1n6cA-1br2A:undetectable | 1n6cA-1br2A:17.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8x | MYOSIN II HEAVYCHAIN FUSED TOALPHA-ACTININ 3 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 5 | ILE A 657ALA A 183GLY A 184GLU A 187ASN A 227 | NoneADP A1100 (-4.1A)ADP A1100 (-3.2A)ADP A1100 (-4.6A)None | 1.02A | 1n6cA-1g8xA:0.0 | 1n6cA-1g8xA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gao | FERREDOXIN I (Azotobactervinelandii) |
PF00037(Fer4)PF11953(DUF3470) | 5 | ILE A 9GLY A 28GLU A 27ASN A 30HIS A 103 | None | 1.43A | 1n6cA-1gaoA:undetectable | 1n6cA-1gaoA:14.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | ILE A 23ALA A 46GLY A 44ASN A 230TYR A 235 | None | 1.35A | 1n6cA-1itzA:undetectable | 1n6cA-1itzA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jx2 | MYOSIN-2 HEAVYCHAIN,DYNAMIN-A (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | ILE A 668ALA A 194GLY A 195GLU A 198ASN A 238 | NoneADP A1203 (-4.3A)ADP A1203 (-3.1A)ADP A1203 (-4.1A)None | 1.10A | 1n6cA-1jx2A:undetectable | 1n6cA-1jx2A:15.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ka9 | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASE (Thermusthermophilus) |
PF00977(His_biosynth) | 5 | ILE F 114ALA F 166GLY F 167GLU F 168LYS F 100 | None | 1.32A | 1n6cA-1ka9F:undetectable | 1n6cA-1ka9F:21.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mt6 | SET9 (Homo sapiens) |
PF00856(SET)PF02493(MORN) | 9 | ILE A 223ALA A 226GLY A 227GLU A 228ASN A 265LYS A 294ASN A 296HIS A 297TYR A 335 | SAH A 1 ( 4.5A)SAH A 1 (-3.8A)SAH A 1 ( 4.0A)NoneSAH A 1 (-3.6A)SAH A 1 (-2.6A)SAH A 1 (-3.3A)NoneSAH A 1 (-4.4A) | 0.37A | 1n6cA-1mt6A:37.6 | 1n6cA-1mt6A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ox4 | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASEHISHF (Saccharomycescerevisiae) |
PF00117(GATase)PF00977(His_biosynth) | 5 | ILE B 387ALA B 463GLY B 464GLU B 465LYS B 360 | None | 1.37A | 1n6cA-1ox4B:undetectable | 1n6cA-1ox4B:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvd | PYRUVATEDECARBOXYLASE (Saccharomycescerevisiae) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | ILE A 132ALA A 86GLY A 87GLU A 91HIS A 97 | None | 1.42A | 1n6cA-1pvdA:undetectable | 1n6cA-1pvdA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pvg | DNA TOPOISOMERASE II (Saccharomycescerevisiae) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 5 | ILE A 67ALA A 146GLY A 145ASN A 129ASN A 70 | NoneANP A 901 (-3.3A)ANP A 901 (-3.5A)ANP A 901 (-4.0A) MG A 903 ( 2.6A) | 1.31A | 1n6cA-1pvgA:undetectable | 1n6cA-1pvgA:20.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q25 | CATION-INDEPENDENTMANNOSE 6-PHOSPHATERECEPTOR (Bos taurus) |
PF00878(CIMR) | 5 | ALA A 157GLY A 156GLU A 178ASN A 172TYR A 226 | None | 1.50A | 1n6cA-1q25A:2.8 | 1n6cA-1q25A:19.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhg | ATP-DEPENDENTHELICASE PCRA (Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF13361(UvrD_C) | 5 | ALA A 33GLY A 32GLU A 283ASN A 13GLU A 571 | NoneNoneNoneNoneATP A 726 ( 3.8A) | 1.27A | 1n6cA-1qhgA:undetectable | 1n6cA-1qhgA:17.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qhh | PROTEIN (PCRA(SUBUNIT))PROTEIN (PCRA(SUBUNIT))PROTEIN (PCRA(SUBUNIT)) (Geobacillusstearothermophilus;Geobacillusstearothermophilus;Geobacillusstearothermophilus) |
PF00580(UvrD-helicase)PF00580(UvrD-helicase)PF13361(UvrD_C)PF13361(UvrD_C) | 5 | ALA A 33GLY A 32GLU B 283ASN A 13GLU D 571 | ATP A 700 (-3.8A)NoneNoneATP A 700 (-4.7A)ATP A 700 (-3.4A) | 1.29A | 1n6cA-1qhhA:undetectable | 1n6cA-1qhhA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zxn | DNA TOPOISOMERASEII, ALPHA ISOZYME (Homo sapiens) |
PF00204(DNA_gyraseB)PF02518(HATPase_c) | 5 | ILE A 88ALA A 167GLY A 166ASN A 150ASN A 91 | NoneADP A 901 (-3.6A)ADP A 901 ( 3.4A)ADP A 901 (-3.8A) MG A 900 ( 2.5A) | 1.27A | 1n6cA-1zxnA:undetectable | 1n6cA-1zxnA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fg1 | CONSERVEDHYPOTHETICAL PROTEINBT1257 (Bacteroidesthetaiotaomicron) |
PF01661(Macro) | 5 | ALA A 49GLU A 47ASN A 26ASN A 78TRP A 53 | None | 1.13A | 1n6cA-2fg1A:undetectable | 1n6cA-2fg1A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gam | BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE (Mus musculus) |
PF02485(Branch) | 5 | ALA A 324GLY A 285GLU A 320ASN A 215TYR A 295 | NoneNoneNGA A 502 (-2.9A)NoneNone | 1.39A | 1n6cA-2gamA:undetectable | 1n6cA-2gamA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vr5 | GLYCOGEN OPERONPROTEIN GLGX (Sulfolobussolfataricus) |
PF00128(Alpha-amylase)PF02806(Alpha-amylase_C)PF02922(CBM_48) | 5 | ILE A 563ALA A 556ASN A 500LYS A 484ASN A 553 | None | 1.30A | 1n6cA-2vr5A:undetectable | 1n6cA-2vr5A:18.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | ILE A3838GLY A3840ASN A3906HIS A3907TYR A3944 | SAH A4971 (-4.3A)SAH A4971 ( 3.7A)SAH A4971 (-3.1A)SAH A4971 (-4.7A)SAH A4971 (-4.9A) | 0.48A | 1n6cA-2w5zA:11.3 | 1n6cA-2w5zA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wsm | HYDROGENASEEXPRESSION/FORMATIONPROTEIN (HYPB) (Archaeoglobusfulgidus) |
PF02492(cobW) | 5 | ILE A 47ALA A 62GLY A 61TYR A 73GLU A 115 | None | 1.40A | 1n6cA-2wsmA:undetectable | 1n6cA-2wsmA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zc8 | N-ACYLAMINO ACIDRACEMASE (Thermusthermophilus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ALA A 264GLY A 267GLU A 271TYR A 55GLU A 293 | None | 1.40A | 1n6cA-2zc8A:undetectable | 1n6cA-2zc8A:20.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zpb | NITRILE HYDRATASESUBUNIT BETA (Rhodococcuserythropolis) |
PF02211(NHase_beta) | 5 | ILE B 167ALA B 174GLY B 175GLU B 176HIS B 139 | None | 1.18A | 1n6cA-2zpbB:undetectable | 1n6cA-2zpbB:23.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3cbo | HISTONE-LYSINEN-METHYLTRANSFERASESETD7 (Homo sapiens) |
PF00856(SET) | 10 | ILE A 223ALA A 226GLY A 227GLU A 228ASN A 265LYS A 294ASN A 296HIS A 297TYR A 335TRP A 352 | SAH A 1 ( 4.3A)SAH A 1 (-3.7A)SAH A 1 ( 4.0A)SAH A 1 (-4.9A)SAH A 1 (-4.0A)SAH A 1 (-2.7A)SAH A 1 (-3.3A)NoneSAH A 1 (-4.9A)SAH A 1 (-3.9A) | 0.29A | 1n6cA-3cboA:36.4 | 1n6cA-3cboA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cvg | PUTATIVE METALBINDING PROTEIN (Coccidioidesimmitis) |
PF12849(PBP_like_2) | 5 | ILE A 97ALA A 47GLY A 46LYS A 78ASN A 44 | None | 1.21A | 1n6cA-3cvgA:undetectable | 1n6cA-3cvgA:22.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fz5 | POSSIBLE2-HYDROXYCHROMENE-2-CARBOXYLATEISOMERASE (Rhodobactersphaeroides) |
PF01323(DSBA) | 5 | ILE A 168ALA A 163GLY A 160GLU A 161GLU A 5 | None | 1.48A | 1n6cA-3fz5A:undetectable | 1n6cA-3fz5A:19.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gyd | CYCLICNUCLEOTIDE-BINDINGDOMAIN (Methylobacillusflagellatus) |
PF00027(cNMP_binding) | 5 | ILE A 94GLY A 92GLU A 20LYS A 24GLU A 97 | NoneNoneNoneNoneCMP A 300 (-2.8A) | 1.48A | 1n6cA-3gydA:undetectable | 1n6cA-3gydA:20.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hcw | MALTOSE OPERONTRANSCRIPTIONALREPRESSOR (Staphylococcusaureus) |
PF13377(Peripla_BP_3) | 5 | ILE A 147ALA A 306GLY A 303ASN A 165HIS A 162 | NoneNoneNoneGOL A 1 (-3.8A)None | 1.44A | 1n6cA-3hcwA:undetectable | 1n6cA-3hcwA:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kgy | BIFUNCTIONALDEAMINASE-REDUCTASEDOMAIN PROTEIN (Chloroflexusaurantiacus) |
PF01872(RibD_C) | 5 | ILE A 146ALA A 141GLY A 142GLU A 143HIS A 80 | None | 1.21A | 1n6cA-3kgyA:undetectable | 1n6cA-3kgyA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 18ASN A 180ASN A 205HIS A 206TYR A 252 | SFG A 491 ( 4.2A)SFG A 491 (-4.3A)SFG A 491 (-3.3A)NoneSFG A 491 (-4.8A) | 0.65A | 1n6cA-3n71A:6.0 | 1n6cA-3n71A:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pgb | PUTATIVEUNCHARACTERIZEDPROTEIN (Aspergillusnidulans) |
PF01179(Cu_amine_oxid)PF09248(DUF1965) | 5 | ALA A 117GLY A 118GLU A 119ASN A 199GLU A 456 | None | 1.11A | 1n6cA-3pgbA:undetectable | 1n6cA-3pgbA:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pzu | ENDOGLUCANASE (Bacillussubtilis) |
PF00150(Cellulase) | 5 | ALA A 94GLY A 66ASN A 134HIS A 229GLU A 165 | None | 1.45A | 1n6cA-3pzuA:undetectable | 1n6cA-3pzuA:23.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rc0 | N-LYSINEMETHYLTRANSFERASESETD6 (Homo sapiens) |
PF00856(SET)PF09273(Rubis-subs-bind) | 5 | ALA A 73GLY A 74ASN A 251HIS A 252TYR A 285 | SAM A 484 (-3.3A)SAM A 484 (-3.4A)SAM A 484 (-3.1A)NoneSAM A 484 (-4.8A) | 0.82A | 1n6cA-3rc0A:6.7 | 1n6cA-3rc0A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ros | NAD-DEPENDENTALDEHYDEDEHYDROGENASE (Lactobacillusacidophilus) |
PF00171(Aldedh) | 5 | ILE A 350ALA A 326GLY A 325ASN A 354GLU A 367 | None | 1.19A | 1n6cA-3rosA:undetectable | 1n6cA-3rosA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tr9 | DIHYDROPTEROATESYNTHASE (Coxiellaburnetii) |
PF00809(Pterin_bind) | 5 | ILE A 34GLY A 69GLU A 89ASN A 39HIS A 43 | None | 1.24A | 1n6cA-3tr9A:undetectable | 1n6cA-3tr9A:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ttb | EIGHT-HEME NITRITEREDUCTASE (Thioalkalivibrioparadoxus) |
PF02335(Cytochrom_C552) | 5 | ILE A 159ALA A 155GLY A 154ASN A 226HIS A 126 | NoneNoneNoneNoneHEC A1004 (-4.4A) | 1.25A | 1n6cA-3ttbA:undetectable | 1n6cA-3ttbA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c1q | HISTONE-LYSINEN-METHYLTRANSFERASEPRDM9 (Mus musculus) |
PF00856(SET) | 5 | ILE A 253ALA A 256GLY A 257ASN A 320TYR A 357 | SAH A 394 (-4.1A)SAH A 394 (-3.6A)SAH A 394 ( 3.7A)SAH A 394 (-3.4A)None | 0.24A | 1n6cA-4c1qA:7.2 | 1n6cA-4c1qA:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evz | HISF-LUCA (syntheticconstruct) |
PF00977(His_biosynth) | 5 | ILE A 113ALA A 165GLY A 166GLU A 167LYS A 99 | None | 1.37A | 1n6cA-4evzA:undetectable | 1n6cA-4evzA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ig9 | NAD-DEPENDENTPROTEIN DEACETYLASESIRTUIN-1 (Homo sapiens) |
PF02146(SIR2) | 5 | ALA A 262GLY A 263ASN A 342ASN A 346HIS A 363 | None | 1.10A | 1n6cA-4ig9A:undetectable | 1n6cA-4ig9A:22.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9j | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASESUBUNIT HISF (Thermotogamaritima) |
PF00977(His_biosynth) | 5 | ILE A 17ALA A 69GLY A 70GLU A 71LYS A 3 | None | 1.26A | 1n6cA-4j9jA:undetectable | 1n6cA-4j9jA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j9j | IMIDAZOLE GLYCEROLPHOSPHATE SYNTHASESUBUNIT HISF (Thermotogamaritima) |
PF00977(His_biosynth) | 5 | ILE A 138ALA A 190GLY A 191GLU A 192LYS A 124 | None | 1.33A | 1n6cA-4j9jA:undetectable | 1n6cA-4j9jA:22.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mpt | PUTATIVELEU/ILE/VAL-BINDINGPROTEIN (Bordetellapertussis) |
PF13458(Peripla_BP_6) | 5 | ILE A 258ALA A 260ASN A 309ASN A 340TYR A 343 | None | 1.40A | 1n6cA-4mptA:undetectable | 1n6cA-4mptA:23.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n2x | DL-2-HALOACIDDEHALOGENASE (Methylobacteriumsp. CPA1) |
PF10778(DehI) | 5 | ILE A 63ALA A 68GLU A 150ASN A 301TYR A 115 | None | 1.12A | 1n6cA-4n2xA:undetectable | 1n6cA-4n2xA:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o59 | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (Bos taurus) |
PF00044(Gp_dh_N)PF02800(Gp_dh_C) | 5 | ILE O 308ALA O 296GLY O 295GLU O 275LYS O 256 | None | 1.03A | 1n6cA-4o59O:undetectable | 1n6cA-4o59O:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4omu | SHIKIMATEDEHYDROGENASE (Pseudomonasputida) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | ALA A 81GLY A 82GLU A 65ASN A 99GLU A 136 | None | 1.41A | 1n6cA-4omuA:undetectable | 1n6cA-4omuA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3r | ARGINASE (Schistosomamansoni) |
PF00491(Arginase) | 5 | ILE A 138GLY A 140GLU A 143ASN A 110GLU A 304 | None | 1.31A | 1n6cA-4q3rA:undetectable | 1n6cA-4q3rA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 5 | ILE A5406GLY A5408ASN A5474HIS A5475TYR A5512 | SAH A5602 (-4.1A)SAH A5602 (-3.6A)SAH A5602 (-3.1A)NoneNone | 0.47A | 1n6cA-4z4pA:13.9 | 1n6cA-4z4pA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5t | EUKARYOTICTRANSLATIONINITIATION FACTOR 3SUBUNIT A (Oryctolaguscuniculus) |
PF01399(PCI) | 5 | ILE A 329ALA A 325GLU A 423LYS A 278HIS A 297 | None | 1.40A | 1n6cA-5a5tA:undetectable | 1n6cA-5a5tA:10.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e3c | DIPEPTIDYL PEPTIDASE3 (Homo sapiens) |
PF03571(Peptidase_M49) | 5 | ILE A 392GLU A 507ASN A 394TYR A 196GLU A 329 | None | 1.33A | 1n6cA-5e3cA:undetectable | 1n6cA-5e3cA:18.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 5 | ILE A4780GLY A4782ASN A4848HIS A4849TYR A4886 | SAH A5002 (-4.3A)SAH A5002 (-3.5A)SAH A5002 (-2.7A)SAH A5002 (-4.6A)None | 0.58A | 1n6cA-5f59A:13.5 | 1n6cA-5f59A:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6l | HISTONE-LYSINEN-METHYLTRANSFERASE2A (Homo sapiens) |
PF00856(SET) | 5 | ILE A3838GLY A3840ASN A3906HIS A3907TYR A3944 | SAH A4001 (-4.3A)SAH A4001 (-3.4A)SAH A4001 (-3.0A)SAH A4001 (-4.9A)SAH A4001 (-4.9A) | 0.46A | 1n6cA-5f6lA:12.6 | 1n6cA-5f6lA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fqd | DNA DAMAGE-BINDINGPROTEIN 1 (Homo sapiens) |
PF03178(CPSF_A)PF10433(MMS1_N) | 5 | ILE A 61ALA A 34GLY A 17GLU A 312ASN A 355 | None | 1.16A | 1n6cA-5fqdA:undetectable | 1n6cA-5fqdA:14.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbo | BETA-GLUCOSIDASE (Trichodermaharzianum) |
PF00232(Glyco_hydro_1) | 5 | ILE A 302ALA A 222GLY A 306GLU A 307GLU A 150 | None | 1.44A | 1n6cA-5jboA:undetectable | 1n6cA-5jboA:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k5a | PARB DOMAIN PROTEINNUCLEASE (Sulfolobussolfataricus) |
PF02195(ParBc) | 5 | ILE B 201ALA B 171GLU B 158ASN B 202TYR B 226 | None | 1.08A | 1n6cA-5k5aB:undetectable | 1n6cA-5k5aB:23.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 18ASN A 182ASN A 206HIS A 207TYR A 240 | SAM A 501 ( 4.1A)SAM A 501 ( 3.8A)SAM A 501 (-3.2A)None6TM A 502 ( 3.6A) | 0.40A | 1n6cA-5kjmA:6.7 | 1n6cA-5kjmA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nqf | APICAL MEMBRANEANTIGEN 1 (Plasmodiumfalciparum) |
PF02430(AMA-1) | 5 | ILE A 127ALA A 346GLY A 394GLU A 120ASN A 398 | ILE A 127 ( 0.7A)ALA A 346 ( 0.0A)GLY A 394 ( 0.0A)GLU A 120 ( 0.5A)ASN A 398 ( 0.6A) | 1.15A | 1n6cA-5nqfA:undetectable | 1n6cA-5nqfA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5odr | HETERODISULFIDEREDUCTASE, SUBUNIT A (Methanothermococcusthermolithotrophicus) |
PF07992(Pyr_redox_2)PF13187(Fer4_9) | 5 | ILE A 241GLU A 295LYS A 290TYR A 217GLU A 243 | SF4 A 703 ( 4.6A)NoneNoneNoneNone | 1.42A | 1n6cA-5odrA:undetectable | 1n6cA-5odrA:18.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5teg | N-LYSINEMETHYLTRANSFERASEKMT5A (Homo sapiens) |
PF00856(SET) | 5 | GLY A 227ASN A 298HIS A 299TYR A 336TRP A 349 | SAM A 401 ( 4.0A)SAM A 401 (-3.2A)NoneSAM A 401 (-4.8A)SAM A 401 (-3.7A) | 0.80A | 1n6cA-5tegA:12.8 | 1n6cA-5tegA:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u8q | INSULIN-LIKE GROWTHFACTOR 1 RECEPTOR (Homo sapiens) |
no annotation | 5 | ALA A 801GLY A 800GLU A 799ASN A 883ASN A 829 | NoneNoneNoneNAG A1013 (-1.8A)None | 1.06A | 1n6cA-5u8qA:undetectable | 1n6cA-5u8qA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vip | MDCD (Pseudomonasaeruginosa) |
PF01039(Carboxyl_trans) | 5 | ILE B 153ALA B 179GLY B 212LYS B 209GLU B 117 | None | 1.40A | 1n6cA-5vipB:undetectable | 1n6cA-5vipB:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w2m | DNA DC->DU-EDITINGENZYME APOBEC-3F (Homo sapiens) |
no annotation | 5 | ALA A 284GLY A 317GLU A 316HIS A 249GLU A 251 | NoneNoneNone ZN A 801 (-3.9A)None | 1.40A | 1n6cA-5w2mA:undetectable | 1n6cA-5w2mA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxg | - (-) |
no annotation | 5 | GLY A 15ASN A 181ASN A 205HIS A 206TYR A 239 | SAM A 502 ( 3.9A)SAM A 502 ( 4.1A)SAM A 502 (-3.1A)None8HR A 501 ( 4.0A) | 0.41A | 1n6cA-5xxgA:6.8 | 1n6cA-5xxgA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zya | SPLICING FACTOR 3BSUBUNIT 1 (Homo sapiens) |
no annotation | 5 | ALA C 841GLY C 845GLU C 848LYS C 807GLU C 839 | None | 1.39A | 1n6cA-5zyaC:undetectable | 1n6cA-5zyaC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c7v | - (-) |
no annotation | 5 | ILE A 113ALA A 165GLY A 166GLU A 167LYS A 99 | None | 1.27A | 1n6cA-6c7vA:undetectable | 1n6cA-6c7vA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f79 | - (-) |
no annotation | 5 | ALA A 70GLY A 116GLU A 117ASN A 112HIS A 68 | None | 1.48A | 1n6cA-6f79A:undetectable | 1n6cA-6f79A:undetectable |