SIMILAR PATTERNS OF AMINO ACIDS FOR 1N5X_A_TEIA3006_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 LEU A 130
LEU A  99
ARG A  41
VAL A  27
ALA A  43
 None
 1.20A 1n5xA-13pkA:
0.0		 1n5xA-13pkA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		5 LEU A 596
SER A 594
VAL A 523
ALA A 517
ALA A 518
 None
 1.23A 1n5xA-1ciiA:
undetectable		 1n5xA-1ciiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cii COLICIN IA

(Escherichia
coli) 		PF01024
(Colicin)
PF11504
(Colicin_Ia) 		5 LEU A 604
LEU A 596
SER A 594
VAL A 523
ALA A 518
 None
 1.09A 1n5xA-1ciiA:
undetectable		 1n5xA-1ciiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hdi PHOSPHOGLYCERATE
KINASE

(Sus scrofa) 		PF00162
(PGK) 		5 LEU A 117
LEU A  84
VAL A  26
ALA A  42
ALA A  41
 None
 1.10A 1n5xA-1hdiA:
undetectable		 1n5xA-1hdiA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		5 LEU A2764
LEU A2736
THR A2657
ALA A2709
ALA A2694
 None
 1.12A 1n5xA-1lm5A:
undetectable		 1n5xA-1lm5A:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nun FIBROBLAST GROWTH
FACTOR RECEPTOR 2
ISOFORM 2

(Homo sapiens) 		PF07679
(I-set) 		5 LYS B 292
LEU B 327
THR B 268
VAL B 357
ALA B 266
 None
 1.18A 1n5xA-1nunB:
undetectable		 1n5xA-1nunB:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 LEU A 113
LEU A  80
ARG A  38
VAL A  24
ALA A  40
 None
 1.15A 1n5xA-1phpA:
0.0		 1n5xA-1phpA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 LEU A 113
LEU A  80
VAL A  24
ALA A  40
ALA A  39
 None
 1.15A 1n5xA-1phpA:
0.0		 1n5xA-1phpA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8k EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT 1

(Homo sapiens) 		PF00575
(S1)
PF07541
(EIF_2_alpha) 		5 LEU A 167
PHE A 152
VAL A 136
ALA A 155
ALA A 151
 None
 1.24A 1n5xA-1q8kA:
2.7		 1n5xA-1q8kA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		5 LEU A 116
LEU A  83
VAL A  26
ALA A  42
ALA A  41
 None
 1.16A 1n5xA-1qpgA:
0.0		 1n5xA-1qpgA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5a GLUTATHIONE
TRANSFERASE

(Anopheles
cracens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 LEU A 143
THR A 164
VAL A 165
ALA A 157
ALA A 160
 None
 1.22A 1n5xA-1r5aA:
undetectable		 1n5xA-1r5aA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 LEU A  80
ARG A  38
VAL A  24
ALA A  40
ALA A  39
 None
 1.05A 1n5xA-1vpeA:
undetectable		 1n5xA-1vpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 LEU A 113
LEU A  80
VAL A  24
ALA A  40
ALA A  39
 None
 1.15A 1n5xA-1vpeA:
undetectable		 1n5xA-1vpeA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		5 LEU A 180
LEU A 128
VAL A 135
ALA A  69
ALA A 116
 None
 1.23A 1n5xA-1wl1A:
undetectable		 1n5xA-1wl1A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		5 LEU A  81
LEU A  55
SER A  53
VAL A 198
ALA A 194
 None
 1.08A 1n5xA-1xr4A:
undetectable		 1n5xA-1xr4A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN HEAVY CHAIN
FERRITIN LIGHT CHAIN

(Trichoplusia ni) 		PF00210
(Ferritin) 		5 LEU A 197
ASN M   4
LEU A 201
PHE A  72
ALA A 125
 None
 1.22A 1n5xA-1z6oA:
2.3		 1n5xA-1z6oA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c0y PROCATHEPSIN S

(Homo sapiens) 		PF00112
(Peptidase_C1)
PF08246
(Inhibitor_I29) 		5 LEU A  65
ASN A 283
LEU A  76
ALA A 124
ALA A 123
 None
 1.10A 1n5xA-2c0yA:
undetectable		 1n5xA-2c0yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6e 5'-NUCLEOTIDASE SURE

(Thermus
thermophilus) 		PF01975
(SurE) 		5 LEU A  90
LEU A  92
PHE A 127
THR A 148
ALA A  22
 None
 1.24A 1n5xA-2e6eA:
undetectable		 1n5xA-2e6eA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fbv WERNER SYNDROME
HELICASE

(Homo sapiens) 		PF01612
(DNA_pol_A_exo1) 		5 SER A  52
PHE A  49
VAL A  54
ALA A 217
ALA A 214
 None
 1.10A 1n5xA-2fbvA:
undetectable		 1n5xA-2fbvA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gmy HYPOTHETICAL PROTEIN
ATU0492

(Agrobacterium
fabrum) 		PF02627
(CMD) 		5 LEU A 111
LEU A  88
THR A  96
VAL A  95
ALA A 126
 None
 1.17A 1n5xA-2gmyA:
undetectable		 1n5xA-2gmyA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1

(Homo sapiens) 		PF03807
(F420_oxidored)
PF14748
(P5CR_dimer) 		5 LEU A 153
LEU A  15
PHE A   5
VAL A  65
ALA A  69
 None
 1.16A 1n5xA-2gr9A:
undetectable		 1n5xA-2gr9A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2po4 VIRION RNA
POLYMERASE

(Escherichia
virus N4) 		no annotation 5 LEU A 491
LEU A 487
SER A 484
ARG A 480
ALA A 462
 None
 0.97A 1n5xA-2po4A:
undetectable		 1n5xA-2po4A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqv MUTT/NUDIX FAMILY
PROTEIN

(Streptococcus
pneumoniae) 		PF00293
(NUDIX) 		5 LEU A 120
LEU A 137
THR A  40
VAL A  31
ALA A  21
 None
 0.91A 1n5xA-2pqvA:
undetectable		 1n5xA-2pqvA:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		5 LEU A 281
LEU A  53
SER A  31
PHE A  88
ALA A  87
 None
 0.96A 1n5xA-2ps3A:
1.5		 1n5xA-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ps3 HIGH-AFFINITY ZINC
UPTAKE SYSTEM
PROTEIN ZNUA

(Escherichia
coli) 		PF01297
(ZnuA) 		5 LEU A 281
SER A  31
PHE A  88
VAL A  81
ALA A  87
 None
 0.92A 1n5xA-2ps3A:
1.5		 1n5xA-2ps3A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A  12
LEU A 150
ARG A 148
THR A 135
ALA A 133
 LEU  A  12 ( 0.6A)
LEU  A 150 ( 0.5A)
ARG  A 148 ( 0.6A)
THR  A 135 ( 0.8A)
ALA  A 133 ( 0.0A)
 1.15A 1n5xA-2vbfA:
undetectable		 1n5xA-2vbfA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 LEU B 303
ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 None
HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.34A 1n5xA-2w55B:
55.7		 1n5xA-2w55B:
26.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		5 LEU A 688
GLU A 215
SER A 648
ARG A 649
THR A 555
 None
None
None
QPS  A1050 (-3.2A)
None
 1.18A 1n5xA-2x2iA:
undetectable		 1n5xA-2x2iA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		5 ARG A 191
PHE A 238
VAL A 363
ALA A 210
ALA A 209
 None
None
None
ACA  A 601 ( 4.9A)
None
 1.20A 1n5xA-3a2qA:
undetectable		 1n5xA-3a2qA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cei SUPEROXIDE DISMUTASE

(Helicobacter
pylori) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		5 LEU A  52
LEU A  56
SER A  59
VAL A  63
ALA A 141
 None
 1.18A 1n5xA-3ceiA:
undetectable		 1n5xA-3ceiA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		5 LEU A 314
LEU A 225
PHE A 200
THR A 170
ALA A 328
 None
 1.20A 1n5xA-3clmA:
undetectable		 1n5xA-3clmA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 LEU A1096
GLU A1265
THR A 345
ALA A 359
ALA A 360
 None
 1.17A 1n5xA-3f5fA:
undetectable		 1n5xA-3f5fA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fvv UNCHARACTERIZED
PROTEIN

(Bordetella
pertussis) 		PF12710
(HAD) 		5 LEU A  18
LEU A  16
THR A 122
VAL A 121
ALA A 128
 None
 1.20A 1n5xA-3fvvA:
undetectable		 1n5xA-3fvvA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxa SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		5 LEU A  62
SER A 165
THR A  28
VAL A 142
ALA A  32
 None
 0.95A 1n5xA-3fxaA:
undetectable		 1n5xA-3fxaA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz8 THIOL:DISULFIDE
INTERCHANGE PROTEIN
DSBA

(Neisseria
meningitidis) 		PF13462
(Thioredoxin_4) 		5 LEU A 133
LEU A 137
PHE A 143
ALA A 104
ALA A 105
 None
 1.15A 1n5xA-3hz8A:
undetectable		 1n5xA-3hz8A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ita D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC

(Escherichia
coli) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		5 LEU A 197
LEU A 220
SER A 233
ALA A 238
ALA A  13
 None
 1.21A 1n5xA-3itaA:
undetectable		 1n5xA-3itaA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		5 LEU A 347
SER A 342
ARG A 253
VAL A 124
ALA A 147
 None
 1.17A 1n5xA-3js8A:
5.1		 1n5xA-3js8A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la6 TYROSINE-PROTEIN
KINASE WZC

(Escherichia
coli) 		PF13614
(AAA_31) 		5 LEU A 573
LEU A 574
SER A 600
VAL A 499
ALA A 548
 None
 1.07A 1n5xA-3la6A:
undetectable		 1n5xA-3la6A:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3msv NUCLEAR IMPORT
ADAPTOR, NRO1

(Schizosaccharomyces
pombe) 		PF12753
(Nro1) 		5 LEU A 238
LEU A 242
PHE A 249
THR A 199
VAL A 202
 None
 1.18A 1n5xA-3msvA:
undetectable		 1n5xA-3msvA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8o 6-PHOSPHOFRUCTOKINAS
E SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00365
(PFK) 		5 LEU B 681
LEU B 696
SER B 692
THR B 660
ALA B 664
 None
 1.17A 1n5xA-3o8oB:
0.2		 1n5xA-3o8oB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		5 LEU B 666
LEU B 681
SER B 677
VAL B 579
ALA B 649
 None
 1.13A 1n5xA-3opyB:
0.3		 1n5xA-3opyB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp9 TYPE I POLYKETIDE
SYNTHASE PIKAII

(Streptomyces
venezuelae) 		PF08659
(KR) 		5 LEU A 175
THR A 189
VAL A 190
ALA A  49
ALA A  53
 None
 1.10A 1n5xA-3qp9A:
undetectable		 1n5xA-3qp9A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rkg MAGNESIUM
TRANSPORTER MRS2,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 160
LEU A 156
THR A  67
VAL A  68
ALA A 128
 None
 1.17A 1n5xA-3rkgA:
3.1		 1n5xA-3rkgA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K

(Escherichia
coli) 		no annotation 5 LEU J  32
ASN K  40
GLU K  36
ALA K  69
ALA K  70
 None
 1.11A 1n5xA-3rkoJ:
undetectable		 1n5xA-3rkoJ:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 LEU J 147
GLU K  72
LEU N 137
PHE N 140
ALA N 164
 None
 1.14A 1n5xA-3rkoJ:
undetectable		 1n5xA-3rkoJ:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli) 		no annotation 5 LEU J 147
GLU K  72
LEU N 137
SER N 136
PHE N 140
 None
 1.19A 1n5xA-3rkoJ:
undetectable		 1n5xA-3rkoJ:
9.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		11 LEU C 648
ASN C 768
GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1078
ALA C1079
 None
None
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
 0.35A 1n5xA-3sr6C:
65.9		 1n5xA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		10 LEU C 648
LYS C 771
GLU C 802
LEU C 873
SER C 876
ARG C 880
PHE C 914
THR C1010
VAL C1011
ALA C1079
 None
None
RMO  C1317 (-4.4A)
None
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 ( 3.6A)
 0.77A 1n5xA-3sr6C:
65.9		 1n5xA-3sr6C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU C 873
SER C 876
PHE C 914
VAL C1011
ALA C1079
 None
None
RMO  C1317 (-3.6A)
None
RMO  C1317 ( 3.6A)
 1.11A 1n5xA-3sr6C:
65.9		 1n5xA-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tny YFIY (ABC TRANSPORT
SYSTEM
SUBSTRATE-BINDING
PROTEIN)

(Bacillus cereus) 		PF01497
(Peripla_BP_2) 		5 LYS A  59
GLU A  31
VAL A 135
ALA A 268
ALA A 269
 None
 1.22A 1n5xA-3tnyA:
undetectable		 1n5xA-3tnyA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uc9 INCREASED
RECOMBINATION
CENTERS PROTEIN 6

(Saccharomyces
cerevisiae) 		no annotation 5 LEU A 116
LEU A 101
VAL A  68
ALA A 108
ALA A 107
 None
 1.14A 1n5xA-3uc9A:
undetectable		 1n5xA-3uc9A:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umv DEOXYRIBODIPYRIMIDIN
E PHOTO-LYASE

(Oryza sativa) 		PF00875
(DNA_photolyase) 		5 LEU A 206
ASN A  53
LEU A 109
VAL A  40
ALA A  73
 None
 1.12A 1n5xA-3umvA:
undetectable		 1n5xA-3umvA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uv0 MUTATOR 2, ISOFORM B

(Drosophila
melanogaster) 		no annotation 5 LEU A  96
LEU A  87
VAL A  73
ALA A  44
ALA A  58
 None
 1.05A 1n5xA-3uv0A:
undetectable		 1n5xA-3uv0A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uzu RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Burkholderia
pseudomallei) 		PF00398
(RrnaAD) 		5 LEU A  21
LEU A  52
ARG A  59
ALA A  33
ALA A  32
 None
 1.06A 1n5xA-3uzuA:
undetectable		 1n5xA-3uzuA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 5 LEU A 315
LEU A 306
VAL A 154
ALA A 144
ALA A 147
 None
 1.23A 1n5xA-3wvrA:
2.0		 1n5xA-3wvrA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 LEU A 291
LEU A 296
VAL A 282
ALA A 458
ALA A 459
 None
 1.15A 1n5xA-3x0vA:
undetectable		 1n5xA-3x0vA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au2 SERPIN PEPTIDASE
INHIBITOR, CLADE H
(HEAT SHOCK PROTEIN
47), MEMBER 1,
(COLLAGEN BINDING
PROTEIN 1)

(Canis lupus) 		PF00079
(Serpin) 		5 LEU A  50
LEU A  78
SER A  77
VAL A 351
ALA A 329
 None
 1.23A 1n5xA-4au2A:
undetectable		 1n5xA-4au2A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cmn INOSITOL
POLYPHOSPHATE
5-PHOSPHATASE OCRL-1

(Homo sapiens) 		PF03372
(Exo_endo_phos) 		5 LEU A 325
GLU A 294
LEU A 316
THR A 343
VAL A 358
 None
 1.20A 1n5xA-4cmnA:
undetectable		 1n5xA-4cmnA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gf0 GLUTATHIONE
S-TRANSFERASE

(Sulfitobacter
sp. NAS-14.1) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 LEU A  58
LEU A   3
VAL A  16
ALA A  78
ALA A  23
 None
 1.17A 1n5xA-4gf0A:
undetectable		 1n5xA-4gf0A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hyd PUTATIVE
UNCHARACTERIZED
PROTEIN

(Methanoculleus
marisnigri) 		PF06550
(SPP) 		5 LEU A  65
LEU A  61
PHE A  57
VAL A 215
ALA A  80
 None
 1.14A 1n5xA-4hydA:
undetectable		 1n5xA-4hydA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1d ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF13416
(SBP_bac_8) 		5 LEU A 328
SER A 330
PHE A 315
ALA A 299
ALA A 314
 None
 1.02A 1n5xA-4i1dA:
undetectable		 1n5xA-4i1dA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lih GAMMA-GLUTAMYL-GAMMA
-AMINOBUTYRALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 LEU A 307
PHE A 294
THR A 367
VAL A 366
ALA A 324
 None
 1.21A 1n5xA-4lihA:
undetectable		 1n5xA-4lihA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lom IMIDAZOLEGLYCEROL-PH
OSPHATE DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF00475
(IGPD) 		5 LEU A  91
LEU A  87
VAL A 116
ALA A  56
ALA A 187
 None
 1.03A 1n5xA-4lomA:
undetectable		 1n5xA-4lomA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2c PROTEIN-ARGININE
DEIMINASE TYPE-2

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		5 LEU A 555
LEU A 430
SER A 414
VAL A 417
ALA A 458
 None
 1.21A 1n5xA-4n2cA:
undetectable		 1n5xA-4n2cA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o7h GLUTATHIONE
S-TRANSFERASE

(Rhodospirillum
rubrum) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 LEU A 141
LEU A 170
THR A 107
VAL A 106
ALA A 176
 None
 1.23A 1n5xA-4o7hA:
undetectable		 1n5xA-4o7hA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oou BETA-1,4-MANNANASE

(Cryptopygus
antarcticus) 		no annotation 5 LEU B 339
LEU B 309
PHE B 276
VAL B 130
ALA B 174
 None
 1.21A 1n5xA-4oouB:
undetectable		 1n5xA-4oouB:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ph1 BLV CAPSID

(Bovine leukemia
virus) 		PF00607
(Gag_p24) 		5 LEU A 155
LEU A 151
PHE A 147
VAL A 195
ALA A 175
 None
 1.19A 1n5xA-4ph1A:
undetectable		 1n5xA-4ph1A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmw DIS3-LIKE
EXONUCLEASE 2

(Mus musculus) 		PF00773
(RNB)
PF17216
(Rrp44_CSD1) 		5 LEU A 717
LEU A 713
PHE A 697
ALA A 590
ALA A 587
 None
 0.90A 1n5xA-4pmwA:
undetectable		 1n5xA-4pmwA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q22 GLYCOSIDE HYDROLASE
FAMILY 18

(Serratia
proteamaculans) 		PF00704
(Glyco_hydro_18) 		5 LEU A 190
LEU A 150
PHE A 119
ALA A 123
ALA A 122
 None
 1.07A 1n5xA-4q22A:
undetectable		 1n5xA-4q22A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn1 E3 UBIQUITIN-PROTEIN
LIGASE SHPRH

(Homo sapiens) 		no annotation 5 LEU A1121
LEU A1338
PHE A1250
ALA A1210
ALA A1246
 None
 1.09A 1n5xA-4qn1A:
undetectable		 1n5xA-4qn1A:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rkz PUTATIVE
UNCHARACTERIZED
PROTEIN TA1305

(Thermoplasma
acidophilum) 		no annotation 5 LEU A 261
LEU A 257
PHE A 181
VAL A 274
ALA A 180
 None
 1.18A 1n5xA-4rkzA:
undetectable		 1n5xA-4rkzA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uob ENDONUCLEASE III-3

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 LEU A 104
LEU A 289
SER A 292
ALA A 256
ALA A 255
 None
None
None
None
SF4  A1329 ( 4.7A)
 1.19A 1n5xA-4uobA:
2.6		 1n5xA-4uobA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4m PUTATIVE RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Methanocaldococcus
jannaschii) 		PF01946
(Thi4) 		5 LEU A 141
LEU A 225
VAL A  42
ALA A 183
ALA A 231
 None
 1.14A 1n5xA-4y4mA:
undetectable		 1n5xA-4y4mA:
13.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		10 LEU A 648
ASN A 768
GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 None
None
URC  A3007 (-3.0A)
None
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
URC  A3007 (-3.5A)
URC  A3007 (-3.4A)
 0.36A 1n5xA-4yswA:
44.9		 1n5xA-4yswA:
86.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		10 LEU A 648
LYS A 771
GLU A 802
LEU A 873
SER A 876
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 None
None
URC  A3007 (-3.0A)
None
None
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
URC  A3007 (-3.5A)
URC  A3007 (-3.4A)
 0.72A 1n5xA-4yswA:
44.9		 1n5xA-4yswA:
86.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1r B-CELL
DIFFERENTIATION
ANTIGEN CD72

(Mus musculus) 		no annotation 5 LEU A 290
LEU A 286
VAL A 280
ALA A 268
ALA A 269
 None
None
None
None
GOL  A 402 (-3.5A)
 0.99A 1n5xA-5b1rA:
undetectable		 1n5xA-5b1rA:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		5 LEU A 108
LEU A  81
VAL A  24
ALA A  40
ALA A  39
 None
 1.11A 1n5xA-5bt8A:
undetectable		 1n5xA-5bt8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dl8 BENZOATE TRANSPORT
PORIN BENP

(Acinetobacter
baumannii) 		no annotation 5 ASN B 387
SER B  34
VAL B  83
ALA B  38
ALA B  70
 None
 1.01A 1n5xA-5dl8B:
undetectable		 1n5xA-5dl8B:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fse UREASE SUBUNIT ALPHA

(Sporosarcina
pasteurii) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ASN C  73
LEU C  70
THR C 110
VAL C 109
ALA C  85
 None
 1.18A 1n5xA-5fseC:
undetectable		 1n5xA-5fseC:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzt CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 LEU B 688
PHE B 657
VAL B 598
ALA B 661
ALA B 660
 None
 1.08A 1n5xA-5gztB:
undetectable		 1n5xA-5gztB:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 LEU A 688
PHE A 657
VAL A 598
ALA A 661
ALA A 660
 None
 1.05A 1n5xA-5gzuA:
undetectable		 1n5xA-5gzuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gzu CHITINASE

(Paenibacillus
sp. FPU-7) 		PF00704
(Glyco_hydro_18) 		5 LEU A 735
LEU A 688
PHE A 657
ALA A 661
ALA A 660
 None
 1.03A 1n5xA-5gzuA:
undetectable		 1n5xA-5gzuA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hft GAMMA-GLUTAMYLTRANSP
EPTIDASE

(Klebsiella
pneumoniae) 		PF01019
(G_glu_transpept) 		5 LEU B 470
THR A 288
VAL A 285
ALA B 434
ALA B 433
 None
 1.09A 1n5xA-5hftB:
undetectable		 1n5xA-5hftB:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hvc TYPE I MODULAR
POLYKETIDE SYNTHASE

(Mycobacterium
ulcerans) 		PF00550
(PP-binding) 		5 LEU A2132
LEU A2128
PHE A2089
THR A2071
ALA A2099
 None
 1.21A 1n5xA-5hvcA:
undetectable		 1n5xA-5hvcA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		5 LEU A 830
LEU A 828
PHE A 853
VAL A 843
ALA A 819
 None
 1.03A 1n5xA-5irmA:
undetectable		 1n5xA-5irmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvf SITE-DETERMINING
PROTEIN

(Pseudomonas
aeruginosa) 		PF10609
(ParA) 		5 LEU A 163
LEU A 167
VAL A 136
ALA A 143
ALA A 142
 None
 1.15A 1n5xA-5jvfA:
undetectable		 1n5xA-5jvfA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		5 LEU B 236
LEU B 289
THR B 286
VAL B 219
ALA B 309
 None
 1.20A 1n5xA-5kohB:
undetectable		 1n5xA-5kohB:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nws SAACMM

(Streptomyces
antibioticus) 		no annotation 5 LEU A 399
LEU A 406
ARG A 432
VAL A 167
ALA A 409
 None
 0.89A 1n5xA-5nwsA:
undetectable		 1n5xA-5nwsA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uai METHIONYL-TRNA
FORMYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		5 LEU A 246
LEU A 241
THR A 262
VAL A 273
ALA A 308
 None
 1.12A 1n5xA-5uaiA:
undetectable		 1n5xA-5uaiA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyo THIOL:DISULFIDE
INTERCHANGE PROTEIN

(Burkholderia
pseudomallei) 		no annotation 5 ARG A  68
PHE A  39
THR A  97
VAL A 100
ALA A  46
 None
 1.23A 1n5xA-5vyoA:
undetectable		 1n5xA-5vyoA:
4.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 542
LEU A1228
SER A1224
THR A1170
VAL A1171
 None
 1.17A 1n5xA-5welA:
2.2		 1n5xA-5welA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 542
LEU A1228
SER A1224
VAL A1171
ALA A1166
 None
 1.11A 1n5xA-5welA:
2.2		 1n5xA-5welA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu6 SPECKLE TARGETED
PIP5K1A-REGULATED
POLY(A) POLYMERASE

(Homo sapiens) 		PF00076
(RRM_1)
PF03828
(PAP_assoc) 		5 LEU A 434
LEU A 413
VAL A 502
ALA A 570
ALA A 571
 None
 1.18A 1n5xA-5wu6A:
undetectable		 1n5xA-5wu6A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wya ISOLEUCINE
2-EPIMERASE

(Lactobacillus
buchneri) 		PF00202
(Aminotran_3) 		5 LEU A 215
SER A 137
VAL A 170
ALA A 126
ALA A 212
 None
 0.97A 1n5xA-5wyaA:
undetectable		 1n5xA-5wyaA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES28
RIBOSOMAL PROTEIN
US7

(Toxoplasma
gondii) 		PF00177
(Ribosomal_S7)
PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 LEU c  55
LEU c  57
ARG c  62
VAL F 127
ALA c  64
 None
 1.13A 1n5xA-5xxuc:
undetectable		 1n5xA-5xxuc:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bj9 ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 5 ASN A  88
THR A  30
VAL A  29
ALA A  86
ALA A  69
 None
 1.02A 1n5xA-6bj9A:
undetectable		 1n5xA-6bj9A:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cah ABC TRANSPORTER
ATP-BINDING/PERMEASE
PROTEIN RV1747

(Mycobacterium
tuberculosis) 		no annotation 5 LEU A 304
LEU A 254
ARG A 264
ALA A 282
ALA A 281
 None
 1.17A 1n5xA-6cahA:
undetectable		 1n5xA-6cahA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ep3 -

(-) 		no annotation 5 LEU A 110
LEU A 190
ARG A 199
VAL A  91
ALA A  98
 None
None
SO4  A 306 (-3.1A)
None
None
 1.12A 1n5xA-6ep3A:
undetectable		 1n5xA-6ep3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3d ARGININOSUCCINATE
LYASE

(Chelativorans
sp. BNC1) 		no annotation 5 LEU A 434
LEU A 370
VAL A 425
ALA A 414
ALA A 415
 None
 1.06A 1n5xA-6g3dA:
undetectable		 1n5xA-6g3dA:
5.29