SIMILAR PATTERNS OF AMINO ACIDS FOR 1N4H_A_REAA500
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dle | COMPLEMENT FACTOR B (Homo sapiens) |
PF00089(Trypsin) | 5 | GLN A 30ILE A 33ALA A 31VAL A 52VAL A 212 | None | 0.97A | 1n4hA-1dleA:0.0 | 1n4hA-1dleA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dle | COMPLEMENT FACTOR B (Homo sapiens) |
PF00089(Trypsin) | 5 | GLN A 30ILE A 33ALA A 31VAL A 212ALA A 104 | None | 1.02A | 1n4hA-1dleA:0.0 | 1n4hA-1dleA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1erz | N-CARBAMYL-D-AMINOACID AMIDOHYDROLASE (Agrobacteriumsp. KNK712) |
PF00795(CN_hydrolase) | 5 | ILE A 190ALA A 228MET A 183ARG A 181LEU A 113 | None | 1.11A | 1n4hA-1erzA:0.0 | 1n4hA-1erzA:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gud | D-ALLOSE-BINDINGPERIPLASMIC PROTEIN (Escherichiacoli) |
PF13407(Peripla_BP_4) | 5 | CYH A 199ALA A 169VAL A 187ARG A 190ALA A 211 | None | 1.20A | 1n4hA-1gudA:0.0 | 1n4hA-1gudA:20.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1itz | TRANSKETOLASE (Zea mays) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | GLN A 131CYH A 430ILE A 429ALA A 134ALA A 391 | None | 1.22A | 1n4hA-1itzA:0.0 | 1n4hA-1itzA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j2q | PROTEASOME ALPHASUBUNITPROTEASOME BETASUBUNIT (Archaeoglobusfulgidus) |
PF00227(Proteasome)PF10584(Proteasome_A_N) | 5 | GLN A 97ILE A 74ALA A 96ARG H 69LEU A 48 | None | 1.14A | 1n4hA-1j2qA:undetectable | 1n4hA-1j2qA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n3s | GTP CYCLOHYDROLASE I (Escherichiacoli) |
PF01227(GTP_cyclohydroI) | 5 | ALA A 121VAL A 141VAL A 171LEU A 14ALA A 161 | None | 1.24A | 1n4hA-1n3sA:0.0 | 1n4hA-1n3sA:21.48 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1nq7 | NUCLEAR RECEPTORROR-BETA (Rattusnorvegicus) |
PF00104(Hormone_recep) | 11 | GLN A 228CYH A 262ILE A 266ALA A 269VAL A 303ARG A 306MET A 307ARG A 309VAL A 318LEU A 338ALA A 342 | ARL A 800 (-4.7A)ARL A 800 (-3.5A)NoneARL A 800 ( 3.9A)ARL A 800 ( 4.7A)ARL A 800 (-4.4A)ARL A 800 (-3.7A)ARL A 800 ( 4.9A)NoneARL A 800 ( 4.8A)ARL A 800 ( 4.1A) | 0.23A | 1n4hA-1nq7A:41.5 | 1n4hA-1nq7A:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ofe | FERREDOXIN-DEPENDENTGLUTAMATE SYNTHASE 2 (Synechocystissp. PCC 6803) |
PF00310(GATase_2)PF01493(GXGXG)PF01645(Glu_synthase)PF04898(Glu_syn_central) | 5 | ILE A 362VAL A 392VAL A 202LEU A 384ALA A 342 | None | 1.21A | 1n4hA-1ofeA:0.0 | 1n4hA-1ofeA:10.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qon | ACETYLCHOLINESTERASE (Drosophilamelanogaster) |
PF00135(COesterase) | 5 | ILE A 32ALA A 59VAL A 14ARG A 15ALA A 224 | None | 1.04A | 1n4hA-1qonA:undetectable | 1n4hA-1qonA:19.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrv | GLYCOSYLTRANSFERASEGTFD (Amycolatopsisorientalis) |
PF03033(Glyco_transf_28) | 5 | ALA A 21VAL A 48MET A 33VAL A 7ALA A 39 | ALA A 21 ( 0.0A)VAL A 48 ( 0.6A)MET A 33 ( 0.0A)VAL A 7 ( 0.6A)ALA A 39 ( 0.0A) | 1.09A | 1n4hA-1rrvA:undetectable | 1n4hA-1rrvA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rtk | COMPLEMENT FACTOR B (Homo sapiens) |
PF00089(Trypsin)PF00092(VWA) | 5 | GLN A 471ILE A 474ALA A 472VAL A 496VAL A 691 | None | 0.99A | 1n4hA-1rtkA:undetectable | 1n4hA-1rtkA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rtk | COMPLEMENT FACTOR B (Homo sapiens) |
PF00089(Trypsin)PF00092(VWA) | 5 | GLN A 471ILE A 474ALA A 472VAL A 691ALA A 553 | None | 1.05A | 1n4hA-1rtkA:undetectable | 1n4hA-1rtkA:17.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vc9 | NDX1 (Thermusthermophilus) |
PF00293(NUDIX) | 5 | ALA A 120VAL A 8MET A 81ARG A 82ALA A 43 | None | 1.19A | 1n4hA-1vc9A:undetectable | 1n4hA-1vc9A:17.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zo1 | TRANSLATIONINITIATION FACTOR 2 (Escherichiacoli) |
PF00009(GTP_EFTU)PF03144(GTP_EFTU_D2)PF11987(IF-2) | 5 | ILE I 384ALA I 383VAL I 330VAL I 369LEU I 244 | None | 1.24A | 1n4hA-1zo1I:undetectable | 1n4hA-1zo1I:22.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a4k | 3-OXOACYL-[ACYLCARRIER PROTEIN]REDUCTASE (Thermusthermophilus) |
PF13561(adh_short_C2) | 5 | ALA A 74VAL A 34VAL A 118LEU A 221ALA A 85 | None | 1.17A | 1n4hA-2a4kA:undetectable | 1n4hA-2a4kA:23.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2aif | RIBOSOMAL PROTEINL7A (Cryptosporidiumparvum) |
PF01248(Ribosomal_L7Ae) | 5 | ILE A 27ALA A 19VAL A 86LEU A 40ALA A 107 | None | 1.04A | 1n4hA-2aifA:undetectable | 1n4hA-2aifA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gah | HETEROTETRAMERICSARCOSINE OXIDASEALPHA-SUBUNIT (Stenotrophomonasmaltophilia) |
PF01571(GCV_T)PF07992(Pyr_redox_2)PF08669(GCV_T_C)PF13510(Fer2_4) | 5 | ALA A 161ARG A 278ARG A 16LEU A 25ALA A 34 | None | 1.25A | 1n4hA-2gahA:undetectable | 1n4hA-2gahA:13.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2guu | ODCASE (Plasmodiumvivax) |
PF00215(OMPdecase) | 5 | CYH A 37ILE A 38ALA A 337VAL A 32LEU A 157 | None | 1.23A | 1n4hA-2guuA:undetectable | 1n4hA-2guuA:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gx8 | NIF3-RELATED PROTEIN (Bacillus cereus) |
PF01784(NIF3) | 5 | ILE A 208ALA A 161VAL A 216MET A 220VAL A 142 | None | 1.26A | 1n4hA-2gx8A:undetectable | 1n4hA-2gx8A:20.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i9u | CYTOSINE/GUANINEDEAMINASE RELATEDPROTEIN (Clostridiumacetobutylicum) |
PF01979(Amidohydro_1) | 5 | ILE A 153ALA A 155VAL A 130VAL A 374LEU A 386 | None | 1.11A | 1n4hA-2i9uA:undetectable | 1n4hA-2i9uA:21.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ijz | PROBABLE M18-FAMILYAMINOPEPTIDASE 2 (Pseudomonasaeruginosa) |
PF02127(Peptidase_M18) | 5 | ALA A 421ARG A 77VAL A 391LEU A 395ALA A 306 | None | 1.21A | 1n4hA-2ijzA:undetectable | 1n4hA-2ijzA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iss | GLUTAMINEAMIDOTRANSFERASESUBUNIT PDXT (Thermotogamaritima) |
PF01174(SNO) | 5 | CYH D 78ILE D 82ALA D 85ARG D 87ALA D 107 | None | 1.22A | 1n4hA-2issD:undetectable | 1n4hA-2issD:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j4r | EXOPOLYPHOSPHATASE (Aquifexaeolicus) |
PF02541(Ppx-GppA) | 5 | ILE A 16ALA A 84VAL A 111LEU A 55ALA A 96 | None | 1.22A | 1n4hA-2j4rA:undetectable | 1n4hA-2j4rA:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2lao | LYSINE, ARGININE,ORNITHINE-BINDINGPROTEIN (Salmonellaenterica) |
PF00497(SBP_bac_3) | 5 | ILE A 68ALA A 66VAL A 43LEU A 217ALA A 213 | None | 1.06A | 1n4hA-2laoA:undetectable | 1n4hA-2laoA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pan | GLYOXYLATECARBOLIGASE (Escherichiacoli) |
PF00205(TPP_enzyme_M)PF02775(TPP_enzyme_C)PF02776(TPP_enzyme_N) | 5 | GLN A 537ILE A 531ALA A 534VAL A 551LEU A 555 | None | 1.23A | 1n4hA-2panA:undetectable | 1n4hA-2panA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ppg | PUTATIVE ISOMERASE (Sinorhizobiummeliloti) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | ILE A 323ALA A 326VAL A 376LEU A 386ALA A 382 | None | 1.05A | 1n4hA-2ppgA:undetectable | 1n4hA-2ppgA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pt6 | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | ILE A 244ALA A 247VAL A 254LEU A 310ALA A 257 | None | 1.11A | 1n4hA-2pt6A:undetectable | 1n4hA-2pt6A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pzi | PROBABLESERINE/THREONINE-PROTEIN KINASE PKNG (Mycobacteriumtuberculosis) |
PF00069(Pkinase)PF16918(PknG_TPR)PF16919(PknG_rubred) | 5 | ILE A 681VAL A 668ARG A 666VAL A 623ALA A 639 | None | 1.19A | 1n4hA-2pziA:undetectable | 1n4hA-2pziA:17.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rfb | CYTOCHROME P450 (Picrophilustorridus) |
PF00067(p450) | 5 | ARG A 211MET A 209VAL A 231LEU A 111ALA A 317 | None | 1.27A | 1n4hA-2rfbA:undetectable | 1n4hA-2rfbA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vmf | BETA-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2) | 5 | ILE A 414VAL A 416ARG A 507VAL A 350ALA A 357 | NoneNoneEDO A1869 ( 3.7A)NoneNone | 1.21A | 1n4hA-2vmfA:undetectable | 1n4hA-2vmfA:15.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xwb | COMPLEMENT FACTOR B (Homo sapiens) |
PF00084(Sushi)PF00089(Trypsin)PF00092(VWA) | 5 | GLN F 471ILE F 474ALA F 472VAL F 691ALA F 553 | None | 1.00A | 1n4hA-2xwbF:undetectable | 1n4hA-2xwbF:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ycd | GLUTATHIONES-TRANSFERASE (Agrobacteriumtumefaciens) |
PF02798(GST_N)PF13410(GST_C_2) | 5 | GLN A 78ILE A 89VAL A 45LEU A 180ALA A 176 | None | 1.18A | 1n4hA-2ycdA:undetectable | 1n4hA-2ycdA:21.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv3 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Thermusthermophilus) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 5 | ILE A 16ALA A 320VAL A 19ARG A 23LEU A 43 | None | 1.22A | 1n4hA-2yv3A:undetectable | 1n4hA-2yv3A:21.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z0q | RHO GUANINENUCLEOTIDE EXCHANGEFACTOR 3 (Mus musculus) |
PF00621(RhoGEF) | 5 | GLN A 245ILE A 334ALA A 337VAL A 271LEU A 319 | None | 1.28A | 1n4hA-2z0qA:undetectable | 1n4hA-2z0qA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zvf | ALANYL-TRNASYNTHETASE (Archaeoglobusfulgidus) |
PF02272(DHHA1) | 5 | GLN A 886ILE A 865ALA A 869VAL A 884VAL A 814 | None | 1.25A | 1n4hA-2zvfA:undetectable | 1n4hA-2zvfA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvc | UNCHARACTERIZEDPROTEIN ISM_01780 (Roseovariusnubinhibens) |
PF13759(2OG-FeII_Oxy_5) | 5 | ILE A 38ALA A 37MET A 31VAL A 132LEU A 105 | None | 1.07A | 1n4hA-3bvcA:undetectable | 1n4hA-3bvcA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dwf | 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 (Cavia porcellus) |
PF00106(adh_short) | 5 | ILE A 50ALA A 42VAL A 39LEU A 32ALA A 59 | None | 1.21A | 1n4hA-3dwfA:undetectable | 1n4hA-3dwfA:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e4v | NADH:FMNOXIDOREDUCTASE LIKEPROTEIN (Methylobacillusflagellatus) |
PF01613(Flavin_Reduct) | 5 | ILE A 144ALA A 10VAL A 141VAL A 20LEU A 113 | None | 1.20A | 1n4hA-3e4vA:undetectable | 1n4hA-3e4vA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fmx | TARTRATEDEHYDROGENASE/DECARBOXYLASE (Pseudomonasputida) |
PF00180(Iso_dh) | 5 | ILE X 263ALA X 266ARG X 111VAL X 116ALA X 119 | NAI X 401 (-4.5A)NoneNoneNoneNone | 1.13A | 1n4hA-3fmxX:undetectable | 1n4hA-3fmxX:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g8d | BIOTIN CARBOXYLASE (Escherichiacoli) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ILE A 66ALA A 69VAL A 6VAL A 42ALA A 14 | None | 1.21A | 1n4hA-3g8dA:undetectable | 1n4hA-3g8dA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gb0 | PEPTIDASE T (Bacillus cereus) |
PF01546(Peptidase_M20)PF07687(M20_dimer) | 5 | ILE A 211ALA A 210MET A 264VAL A 182ALA A 225 | None | 1.17A | 1n4hA-3gb0A:undetectable | 1n4hA-3gb0A:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibs | CONSERVEDHYPOTHETICAL PROTEINBATB (Bacteroidesthetaiotaomicron) |
PF00092(VWA) | 5 | ILE A 199ALA A 195VAL A 187ARG A 188ALA A 179 | None | 1.13A | 1n4hA-3ibsA:undetectable | 1n4hA-3ibsA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ixw | HEMOCYANIN AA6 CHAIN (Androctonusaustralis) |
PF00372(Hemocyanin_M)PF03722(Hemocyanin_N)PF03723(Hemocyanin_C) | 5 | VAL A 94ARG A 99VAL A 61LEU A 53ALA A 56 | None | 1.28A | 1n4hA-3ixwA:undetectable | 1n4hA-3ixwA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kb3 | PROTEIN PHOSPHATASE2C 16 (Arabidopsisthaliana) |
PF00481(PP2C) | 5 | GLN B 475ILE B 496ALA B 478VAL B 498VAL B 208 | None | 1.26A | 1n4hA-3kb3B:undetectable | 1n4hA-3kb3B:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kn1 | GOLGI PHOSPHOPROTEIN3 (Homo sapiens) |
PF05719(GPP34) | 5 | CYH A 92ILE A 95ALA A 98VAL A 288ALA A 295 | None | 1.15A | 1n4hA-3kn1A:undetectable | 1n4hA-3kn1A:24.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3l4i | HEAT SHOCK 70(HSP70) PROTEIN (Cryptosporidiumparvum) |
PF00012(HSP70) | 5 | GLN A 141ILE A 180ALA A 181VAL A 57ALA A 85 | None | 1.19A | 1n4hA-3l4iA:undetectable | 1n4hA-3l4iA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ls2 | S-FORMYLGLUTATHIONEHYDROLASE (Pseudoalteromonashaloplanktis) |
PF00756(Esterase) | 5 | GLN A 17ALA A 32VAL A 10LEU A 271ALA A 71 | None | 1.23A | 1n4hA-3ls2A:undetectable | 1n4hA-3ls2A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lwg | HP0420 HOMOLOGUE (Helicobacterfelis) |
no annotation | 5 | ILE A 86ALA A 84VAL A 119VAL A 80ALA A 60 | None | 1.12A | 1n4hA-3lwgA:undetectable | 1n4hA-3lwgA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nrb | FORMYLTETRAHYDROFOLATE DEFORMYLASE (Pseudomonasputida) |
PF00551(Formyl_trans_N)PF01842(ACT) | 5 | ALA A 165ARG A 188VAL A 266LEU A 101ALA A 171 | None | 1.08A | 1n4hA-3nrbA:undetectable | 1n4hA-3nrbA:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o04 | BETA-KETO-ACYLCARRIER PROTEINSYNTHASE II (Listeriamonocytogenes) |
PF00109(ketoacyl-synt)PF02801(Ketoacyl-synt_C) | 5 | ILE A 105ALA A 82VAL A 147ARG A 150VAL A 101 | None | 1.26A | 1n4hA-3o04A:undetectable | 1n4hA-3o04A:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3oit | OS07G0271500 PROTEIN (Oryza sativa) |
PF00195(Chal_sti_synt_N)PF02797(Chal_sti_synt_C) | 5 | ILE A 248ALA A 27VAL A 234ARG A 195ALA A 180 | None | 1.25A | 1n4hA-3oitA:undetectable | 1n4hA-3oitA:20.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qgv | ALPHA AMYLASE (Pyrococcuswoesei) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ILE A 93ALA A 96VAL A 103LEU A 70ALA A 50 | None | 1.10A | 1n4hA-3qgvA:undetectable | 1n4hA-3qgvA:21.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s8m | ENOYL-ACP REDUCTASE (Xanthomonasoryzae) |
PF07055(Eno-Rase_FAD_bd)PF12241(Enoyl_reductase)PF12242(Eno-Rase_NADH_b) | 5 | GLN A 179ILE A 231ALA A 167VAL A 284VAL A 355 | None | 1.16A | 1n4hA-3s8mA:undetectable | 1n4hA-3s8mA:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3slk | POLYKETIDE SYNTHASEEXTENDER MODULE 2 (Saccharopolysporaspinosa) |
PF08240(ADH_N)PF08659(KR)PF13602(ADH_zinc_N_2) | 5 | ILE A 342ALA A 340VAL A 495LEU A 371ALA A 356 | NoneNoneNoneNoneNDP A 801 (-3.1A) | 1.12A | 1n4hA-3slkA:undetectable | 1n4hA-3slkA:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tzw | POLYKETIDE SYNTHASEPKS13 (Mycobacteriumtuberculosis) |
PF00698(Acyl_transf_1) | 5 | ILE A1057ALA A1055VAL A 625LEU A 689ALA A 685 | None | 1.25A | 1n4hA-3tzwA:undetectable | 1n4hA-3tzwA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wj7 | PUTATIVEOXIDOREDUCTASE (Gluconobacteroxydans) |
PF01370(Epimerase) | 5 | ILE A 196ALA A 328VAL A 182ARG A 319LEU A 246 | None | 1.13A | 1n4hA-3wj7A:undetectable | 1n4hA-3wj7A:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wuy | NITRILASE (Synechocystissp. PCC 6803) |
PF00795(CN_hydrolase) | 5 | ILE A 38ALA A 97VAL A 104LEU A 272ALA A 16 | None | 1.07A | 1n4hA-3wuyA:undetectable | 1n4hA-3wuyA:22.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zyv | AOX3 (Mus musculus) |
PF00111(Fer2)PF00941(FAD_binding_5)PF01315(Ald_Xan_dh_C)PF01799(Fer2_2)PF02738(Ald_Xan_dh_C2)PF03450(CO_deh_flav_C) | 5 | ILE A1307ALA A1310VAL A1283ARG A1287ALA A1278 | None | 1.20A | 1n4hA-3zyvA:undetectable | 1n4hA-3zyvA:12.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4auk | RIBOSOMAL RNA LARGESUBUNITMETHYLTRANSFERASE M (Escherichiacoli) |
PF01728(FtsJ) | 5 | ILE A 336ALA A 334ARG A 354LEU A 305ALA A 286 | NoneNoneTLA A1363 (-2.8A)NoneNone | 1.25A | 1n4hA-4aukA:undetectable | 1n4hA-4aukA:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bmh | ACETYLTRANSFERASE (Streptomycessviceus) |
PF00583(Acetyltransf_1) | 6 | CYH A 75ILE A 74ALA A 121VAL A 113ARG A 64VAL A 104 | None | 1.50A | 1n4hA-4bmhA:undetectable | 1n4hA-4bmhA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dal | PUTATIVE ALDEHYDEDEHYDROGENASE (Sinorhizobiummeliloti) |
PF00171(Aldedh) | 5 | ILE A 268ALA A 283VAL A 253LEU A 261ALA A 259 | None | 0.88A | 1n4hA-4dalA:undetectable | 1n4hA-4dalA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4du6 | GTP CYCLOHYDROLASE 1 (Yersinia pestis) |
PF01227(GTP_cyclohydroI) | 5 | ALA A 120VAL A 140VAL A 170LEU A 15ALA A 160 | None | 1.25A | 1n4hA-4du6A:undetectable | 1n4hA-4du6A:22.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ezb | UNCHARACTERIZEDCONSERVED PROTEIN (Sinorhizobiummeliloti) |
PF03807(F420_oxidored)PF09130(DUF1932) | 5 | ILE A 62ALA A 5VAL A 68VAL A 72ALA A 81 | None | 1.21A | 1n4hA-4ezbA:undetectable | 1n4hA-4ezbA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4igm | 2-AMINO-3-CARBOXYMUCONATE-6-SEMIALDEHYDEDECARBOXYLASE (Homo sapiens) |
PF04909(Amidohydro_2) | 5 | ILE A 143MET A 129ARG A 131LEU A 218ALA A 164 | None | 1.24A | 1n4hA-4igmA:undetectable | 1n4hA-4igmA:20.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kqk | NICOTINATE-NUCLEOTIDE--DIMETHYLBENZIMIDAZOLEPHOSPHORIBOSYLTRANSFERASE (Salmonellaenterica) |
PF02277(DBI_PRT) | 5 | ALA A 254VAL A 281VAL A 172LEU A 235ALA A 270 | None | 1.06A | 1n4hA-4kqkA:undetectable | 1n4hA-4kqkA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l3w | LIPASE (Rhizopusmicrosporus) |
PF01764(Lipase_3) | 5 | ILE A 94ARG A 108VAL A 146LEU A 185ALA A 181 | None | 0.99A | 1n4hA-4l3wA:undetectable | 1n4hA-4l3wA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6b | SERINEACETYLTRANSFERASEAPOENZYME (Glycine max) |
PF00132(Hexapep)PF06426(SATase_N) | 5 | ALA A 81VAL A 127ARG A 133LEU A 69ALA A 142 | None | 1.13A | 1n4hA-4n6bA:undetectable | 1n4hA-4n6bA:20.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4okq | HUT OPERON POSITIVEREGULATORY PROTEIN (Geobacillusthermodenitrificans) |
PF09021(HutP) | 5 | ILE A 80ALA A 79VAL A 124VAL A 65ALA A 58 | None | 1.02A | 1n4hA-4okqA:undetectable | 1n4hA-4okqA:19.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4omu | SHIKIMATEDEHYDROGENASE (Pseudomonasputida) |
PF01488(Shikimate_DH)PF08501(Shikimate_dh_N) | 5 | ILE A 184VAL A 181ARG A 121VAL A 115ALA A 233 | None | 0.98A | 1n4hA-4omuA:undetectable | 1n4hA-4omuA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qaw | XYN30D (Paenibacillusbarcinonensis) |
PF03422(CBM_6)PF17189(Glyco_hydro_30C) | 5 | ILE A 6ALA A 4VAL A 369LEU A 390ALA A 388 | None | 1.23A | 1n4hA-4qawA:undetectable | 1n4hA-4qawA:17.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rzm | EPOXIDE HYDROLASELASB (Streptomyceslasaliensis) |
PF12680(SnoaL_2) | 5 | ALA A 83ARG A 101ARG A 99VAL A 63LEU A 36 | FMT A 303 ( 4.3A)NoneNoneNoneNone | 1.12A | 1n4hA-4rzmA:undetectable | 1n4hA-4rzmA:18.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4s15 | NUCLEAR RECEPTORROR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 8 | CYH A 323ILE A 327ALA A 330VAL A 364ARG A 367MET A 368ARG A 370VAL A 379 | 4D8 A 601 ( 4.0A)None4D8 A 601 (-3.1A)NoneGOL A 602 (-4.5A)4D8 A 601 (-4.0A)GOL A 602 (-3.3A)None | 0.33A | 1n4hA-4s15A:36.7 | 1n4hA-4s15A:59.62 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4s15 | NUCLEAR RECEPTORROR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 8 | GLN A 289CYH A 323ILE A 327ALA A 330VAL A 364MET A 368ARG A 370VAL A 379 | 4D8 A 601 ( 2.7A)4D8 A 601 ( 4.0A)None4D8 A 601 (-3.1A)None4D8 A 601 (-4.0A)GOL A 602 (-3.3A)None | 0.74A | 1n4hA-4s15A:36.7 | 1n4hA-4s15A:59.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tu3 | VACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN 74 (Saccharomycescerevisiae) |
PF05719(GPP34) | 5 | ILE A 160VAL A 337ARG A 340MET A 341ALA A 262 | None | 1.16A | 1n4hA-4tu3A:undetectable | 1n4hA-4tu3A:23.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uoe | SPERMIDINE SYNTHASE (Plasmodiumfalciparum) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 5 | ILE A 244ALA A 247VAL A 254LEU A 310ALA A 257 | None | 1.11A | 1n4hA-4uoeA:undetectable | 1n4hA-4uoeA:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uzu | ALPHA-AMYLASE (Geobacillusstearothermophilus) |
PF00128(Alpha-amylase)PF09154(DUF1939) | 5 | ILE A 88ALA A 91VAL A 98LEU A 65ALA A 46 | None | 1.23A | 1n4hA-4uzuA:undetectable | 1n4hA-4uzuA:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wrr | PUTATIVEDIACYLGLYCEROLKINASE (Bacillusanthracis) |
PF00781(DAGK_cat) | 5 | ILE A 118ALA A 114VAL A 107ARG A 103VAL A 74 | None | 1.25A | 1n4hA-4wrrA:undetectable | 1n4hA-4wrrA:23.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfk | PUTATIVE BRANCHEDCHAIN AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Brucella ovis) |
PF13458(Peripla_BP_6) | 5 | ILE A 280ALA A 283VAL A 285ARG A 230ALA A 314 | None | 1.11A | 1n4hA-4xfkA:undetectable | 1n4hA-4xfkA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xfk | PUTATIVE BRANCHEDCHAIN AMINO ACID ABCTRANSPORTER,PERIPLASMIC AMINOACID-BINDING PROTEIN (Brucella ovis) |
PF13458(Peripla_BP_6) | 5 | ILE A 280VAL A 285ARG A 230VAL A 248ALA A 314 | None | 1.08A | 1n4hA-4xfkA:undetectable | 1n4hA-4xfkA:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y1p | 3-ISOPROPYLMALATEDEHYDROGENASE (Sulfolobusacidocaldarius) |
PF00180(Iso_dh) | 5 | ILE A 332ALA A 331VAL A 308VAL A 319LEU A 276 | None | 1.22A | 1n4hA-4y1pA:undetectable | 1n4hA-4y1pA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zck | GTP-BINDING PROTEINTYPA/BIPA (Escherichiacoli) |
PF00679(EFG_C) | 5 | ILE A 449VAL A 307MET A 309ARG A 357VAL A 382 | None | 1.11A | 1n4hA-4zckA:undetectable | 1n4hA-4zckA:22.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zdk | CTP SYNTHASE (Mycobacteriumtuberculosis) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | ILE A 401ALA A 404VAL A 425VAL A 508LEU A 394 | NoneNoneNoneNoneONL A 601 ( 4.1A) | 1.07A | 1n4hA-4zdkA:undetectable | 1n4hA-4zdkA:18.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a5g | FORMATE--TETRAHYDROFOLATE LIGASE (Tepidanaerobacteracetatoxydans) |
PF01268(FTHFS) | 5 | ALA A 115VAL A 410VAL A 297LEU A 86ALA A 422 | None | 1.17A | 1n4hA-5a5gA:undetectable | 1n4hA-5a5gA:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5c2v | HYDRAZINE SYNTHASEALPHA SUBUNIT (CandidatusKueneniastuttgartiensis) |
no annotation | 5 | CYH A 583ILE A 459ALA A 603VAL A 489LEU A 575 | HEC A 905 (-1.8A)NoneNoneNoneNone | 1.19A | 1n4hA-5c2vA:undetectable | 1n4hA-5c2vA:16.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c4t | NUCLEAR RECEPTORROR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | CYH A 320ALA A 327VAL A 361ARG A 364ARG A 367VAL A 376LEU A 396 | GOL A 607 ( 4.0A)NoneNoneNoneNoneNoneNone | 0.74A | 1n4hA-5c4tA:29.8 | 1n4hA-5c4tA:49.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c4t | NUCLEAR RECEPTORROR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | CYH A 320ALA A 327VAL A 361ARG A 364MET A 365ARG A 367LEU A 396 | GOL A 607 ( 4.0A)NoneNoneNoneNoneNoneNone | 0.79A | 1n4hA-5c4tA:29.8 | 1n4hA-5c4tA:49.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c4t | NUCLEAR RECEPTORROR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | GLN A 286CYH A 320ALA A 327VAL A 361ARG A 367VAL A 376LEU A 396 | NoneGOL A 607 ( 4.0A)NoneNoneNoneNoneNone | 1.05A | 1n4hA-5c4tA:29.8 | 1n4hA-5c4tA:49.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5c4t | NUCLEAR RECEPTORROR-GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 7 | GLN A 286CYH A 320ALA A 327VAL A 361MET A 365ARG A 367LEU A 396 | NoneGOL A 607 ( 4.0A)NoneNoneNoneNoneNone | 1.06A | 1n4hA-5c4tA:29.8 | 1n4hA-5c4tA:49.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cwo | DESIGNED HELICALREPEAT PROTEIN (syntheticconstruct) |
no annotation | 5 | GLN A 110ILE A 104ALA A 107VAL A 116ALA A 123 | None | 1.14A | 1n4hA-5cwoA:undetectable | 1n4hA-5cwoA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h80 | CARBOXYLASE (Deinococcusradiodurans) |
PF00289(Biotin_carb_N)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | ILE A 254ALA A 257VAL A 210VAL A 276ALA A 242 | None | 0.79A | 1n4hA-5h80A:undetectable | 1n4hA-5h80A:18.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k0y | RIBOSOMAL PROTEINES17 (Oryctolaguscuniculus) |
no annotation | 5 | ILE e 16ALA e 13VAL e 54MET e 58ARG e 60 | NoneNoneNoneNone C A1460 ( 3.6A) | 1.11A | 1n4hA-5k0ye:undetectable | 1n4hA-5k0ye:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k9x | TRYPTOPHAN SYNTHASEALPHA CHAIN (Legionellapneumophila) |
PF00290(Trp_syntA) | 5 | ILE A 52ALA A 25VAL A 81VAL A 97ALA A 118 | None | 1.20A | 1n4hA-5k9xA:undetectable | 1n4hA-5k9xA:19.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mru | TETRACYCLINEREPRESSOR, CLASS A (Pseudomonas sp.) |
no annotation | 5 | ILE A 99ARG A 94VAL A 145LEU A 60ALA A 89 | NoneNoneNoneTDC A 301 ( 4.9A)None | 1.18A | 1n4hA-5mruA:undetectable | 1n4hA-5mruA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5opj | RHAMNOGALACTURONANLYASE (Bacteroidesthetaiotaomicron) |
no annotation | 5 | CYH A 782ILE A 724VAL A 680VAL A 800LEU A 773 | None | 1.26A | 1n4hA-5opjA:undetectable | 1n4hA-5opjA:15.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tch | TRYPTOPHAN SYNTHASEBETA CHAIN (Mycobacteriumtuberculosis) |
PF00291(PALP) | 5 | GLN B 229ILE B 254ALA B 226VAL B 386ALA B 368 | None | 1.28A | 1n4hA-5tchB:undetectable | 1n4hA-5tchB:20.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tp4 | AMIDASE,HYDANTOINASE/CARBAMOYLASE FAMILY (Burkholderiaambifaria) |
PF01546(Peptidase_M20) | 5 | ALA A 47VAL A 57MET A 55VAL A 107LEU A 80 | None | 1.09A | 1n4hA-5tp4A:undetectable | 1n4hA-5tp4A:19.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y1i | CYTOCHROME P450 (Streptomycesgraminofaciens) |
PF00067(p450) | 5 | GLN A 402ILE A 296ALA A 404VAL A 151LEU A 373 | None | 1.21A | 1n4hA-5y1iA:undetectable | 1n4hA-5y1iA:21.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y33 | ALGINATE LYASE (Flavobacteriumsp. UMI-01) |
no annotation | 5 | ILE A 104ALA A 249VAL A 118LEU A 198ALA A 121 | None | 1.04A | 1n4hA-5y33A:undetectable | 1n4hA-5y33A:14.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ayv | FRUCTOSE-1,6-BISPHOSPHATASE CLASS 2 (Mycobacteriumtuberculosis) |
no annotation | 5 | ILE A 134VAL A 154MET A 152ARG A 175LEU A 128 | GOL A 404 ( 4.4A)NoneNoneNoneNone | 1.22A | 1n4hA-6ayvA:undetectable | 1n4hA-6ayvA:12.60 |