SIMILAR PATTERNS OF AMINO ACIDS FOR 1N49_D_RITD401_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f3o | HYPOTHETICAL ABCTRANSPORTERATP-BINDING PROTEINMJ0796 (Methanocaldococcusjannaschii) |
PF00005(ABC_tran) | 4 | ASP A 83GLY A 86ILE A 167ILE A 64 | None | 0.89A | 1n49D-1f3oA:undetectable | 1n49D-1f3oA:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fcu | HYALURONOGLUCOSAMINIDASE (Apis mellifera) |
PF01630(Glyco_hydro_56) | 4 | ASN A 16GLY A 182ILE A 110ILE A 51 | None | 0.89A | 1n49D-1fcuA:undetectable | 1n49D-1fcuA:10.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g67 | THIAMIN PHOSPHATESYNTHASE (Bacillussubtilis) |
PF02581(TMP-TENI) | 4 | ASP A 203GLY A 185ILE A 153ILE A 228 | None | 0.89A | 1n49D-1g67A:undetectable | 1n49D-1g67A:18.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1hcu | ALPHA-1,2-MANNOSIDASE (Trichodermareesei) |
PF01532(Glyco_hydro_47) | 4 | ASP A 114GLY A 108ILE A 59ILE A 66 | None | 0.83A | 1n49D-1hcuA:undetectable | 1n49D-1hcuA:12.33 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.7A)A79 A 800 (-3.4A)A79 A 800 ( 4.0A)A79 A 800 ( 3.4A)A79 A 800 (-3.8A) | 0.43A | 1n49D-1hvcA:13.9 | 1n49D-1hvcA:47.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1hvc | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | A79 A 800 (-2.8A)A79 A 800 ( 3.7A)A79 A 800 (-3.8A)A79 A 800 ( 3.9A)A79 A 800 (-3.6A) | 0.41A | 1n49D-1hvcA:13.9 | 1n49D-1hvcA:47.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ih5 | AQUAPORIN-1 (Homo sapiens) |
PF00230(MIP) | 4 | ASN A 192GLY A 173ILE A 172ILE A 191 | None | 0.93A | 1n49D-1ih5A:undetectable | 1n49D-1ih5A:14.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iwp | GLYCEROL DEHYDRATASEALPHA SUBUNIT (Klebsiellapneumoniae) |
PF02286(Dehydratase_LU) | 4 | ASP A 372GLY A 175ILE A 176ILE A 155 | None | 0.88A | 1n49D-1iwpA:undetectable | 1n49D-1iwpA:10.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jlx | AGGLUTININ (Amaranthuscaudatus) |
PF07468(Agglutinin) | 4 | ASN A 181ASP A 226GLY A 273ILE A 180 | None | 0.89A | 1n49D-1jlxA:undetectable | 1n49D-1jlxA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mld | MALATE DEHYDROGENASE (Sus scrofa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ASN A 93GLY A 10ILE A 12ILE A 96 | None | 0.93A | 1n49D-1mldA:undetectable | 1n49D-1mldA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mld | MALATE DEHYDROGENASE (Sus scrofa) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ASN A 118ASP A 87GLY A 178ILE A 181 | CIT A 375 (-3.2A)NoneNoneNone | 0.90A | 1n49D-1mldA:undetectable | 1n49D-1mldA:16.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1mpt | M-PROTEASE (Bacillusclausii) |
PF00082(Peptidase_S8) | 4 | ASP A 60GLY A 70ILE A 72ILE A 44 | None | 0.93A | 1n49D-1mptA:undetectable | 1n49D-1mptA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1n61 | CARBON MONOXIDEDEHYDROGENASE MEDIUMCHAIN (Oligotrophacarboxidovorans) |
PF00941(FAD_binding_5)PF03450(CO_deh_flav_C) | 4 | ASP C 124GLY C 215ILE C 214ILE C 93 | FAD C3932 (-3.8A)NoneNoneNone | 0.83A | 1n49D-1n61C:undetectable | 1n49D-1n61C:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q1r | PUTIDAREDOXINREDUCTASE (Pseudomonasputida) |
PF07992(Pyr_redox_2)PF14759(Reductase_C) | 4 | ASP A 284GLY A 11ILE A 9ILE A 266 | FAD A 749 (-2.7A)FAD A 749 (-3.0A)NoneNone | 0.86A | 1n49D-1q1rA:undetectable | 1n49D-1q1rA:13.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q50 | GLUCOSE-6-PHOSPHATEISOMERASE (Leishmaniamexicana) |
PF00342(PGI) | 4 | ASN A 381GLY A 556ILE A 557ILE A 377 | None | 0.66A | 1n49D-1q50A:undetectable | 1n49D-1q50A:10.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rhx | CONSERVEDHYPOTHETICAL PROTEINTM0979 (Thermotogamaritima) |
PF04077(DsrH) | 4 | ASP A 54GLY A 87ILE A 86PRO A 13 | None | 0.91A | 1n49D-1rhxA:undetectable | 1n49D-1rhxA:20.39 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1siv | SIV PROTEASE (Simianimmunodeficiencyvirus) |
PF00077(RVP) | 5 | ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.33A | 1n49D-1sivA:18.8 | 1n49D-1sivA:48.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1smk | MALATEDEHYDROGENASE,GLYOXYSOMAL (Citrulluslanatus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ASN A 137GLY A 54ILE A 56ILE A 140 | None | 0.87A | 1n49D-1smkA:undetectable | 1n49D-1smkA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1t06 | HYPOTHETICAL PROTEIN (Bacillus cereus) |
PF08713(DNA_alkylation) | 4 | ASN A 176GLY A 197ILE A 198ILE A 217 | None | 0.95A | 1n49D-1t06A:undetectable | 1n49D-1t06A:17.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tkk | SIMILAR TOCHLOROMUCONATECYCLOISOMERASE (Bacillussubtilis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASP A 109GLY A 303ILE A 304ILE A 275 | None | 0.78A | 1n49D-1tkkA:undetectable | 1n49D-1tkkA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tww | DHPS,DIHYDROPTEROATESYNTHASE (Bacillusanthracis) |
PF00809(Pterin_bind) | 4 | ASP A 101GLY A 24ILE A 22ILE A 118 | HH2 A 282 (-3.4A)NoneNoneNone | 0.90A | 1n49D-1twwA:undetectable | 1n49D-1twwA:16.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zor | ISOCITRATEDEHYDROGENASE (Thermotogamaritima) |
PF00180(Iso_dh) | 4 | ASP A 228ILE A 185PRO A 293ILE A 193 | None | 0.83A | 1n49D-1zorA:undetectable | 1n49D-1zorA:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bf6 | EXO-ALPHA-SIALIDASE (Clostridiumperfringens) |
PF13088(BNR_2) | 4 | ASP A 335ILE A 593PRO A 483ILE A 332 | None | 0.92A | 1n49D-2bf6A:undetectable | 1n49D-2bf6A:13.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bih | NITRATE REDUCTASE[NADPH] (Ogataea angusta) |
PF00174(Oxidored_molyb)PF03404(Mo-co_dimer) | 4 | ASP A 129GLY A 174ILE A 177ILE A 124 | None | 0.93A | 1n49D-2bihA:undetectable | 1n49D-2bihA:11.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d57 | AQUAPORIN-4 (Rattusnorvegicus) |
PF00230(MIP) | 4 | ASN A 229GLY A 209PRO A 237ILE A 232 | None | 0.85A | 1n49D-2d57A:undetectable | 1n49D-2d57A:15.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ec5 | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 4 | ASP A 739GLY A 803ILE A 802ILE A 734 | None | 0.71A | 1n49D-2ec5A:undetectable | 1n49D-2ec5A:9.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fj0 | CARBOXYLIC ESTERHYDROLASE (Manduca sexta) |
PF00135(COesterase) | 4 | GLY A 352ILE A 351PRO A 517ILE A 508 | None | 0.87A | 1n49D-2fj0A:undetectable | 1n49D-2fj0A:10.67 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2fmb | EQUINE INFECTIOUSANEMIA VIRUSPROTEASE (Equineinfectiousanemia virus) |
PF00077(RVP) | 4 | ASP A 29GLY A 55PRO A 86ILE A 89 | LP1 A 201 (-3.6A)LP1 A 201 (-3.4A)LP1 A 201 (-3.9A)LP1 A 201 (-4.2A) | 0.40A | 1n49D-2fmbA:15.2 | 1n49D-2fmbA:32.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ggv | NON-STRUCTURALPROTEIN 3 (West Nile virus) |
PF00949(Peptidase_S7) | 4 | ASP B 75GLY B 148ILE B 139ILE B 123 | None | 0.93A | 1n49D-2ggvB:undetectable | 1n49D-2ggvB:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i4c | BICARBONATETRANSPORTER (Synechocystissp. PCC 6803) |
PF13379(NMT1_2) | 4 | GLY A 380ILE A 377PRO A 123ILE A 132 | None | 0.84A | 1n49D-2i4cA:undetectable | 1n49D-2i4cA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ia2 | PUTATIVETRANSCRIPTIONALREGULATOR (Rhodococcusjostii) |
PF01614(IclR)PF09339(HTH_IclR) | 4 | ASP A 120GLY A 140PRO A 93ILE A 115 | None | 0.81A | 1n49D-2ia2A:undetectable | 1n49D-2ia2A:17.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jv2 | PUTATIVEUNCHARACTERIZEDPROTEIN PH1500 (Pyrococcushorikoshii) |
PF02933(CDC48_2) | 4 | ASP A 46GLY A 49ILE A 50PRO A 21 | None | 0.91A | 1n49D-2jv2A:undetectable | 1n49D-2jv2A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kfk | CELL DIVISIONCONTROL PROTEIN 24 (Saccharomycescerevisiae) |
PF00564(PB1) | 4 | ASN B 134ASP B 127GLY B 161ILE B 133 | None | 0.88A | 1n49D-2kfkB:undetectable | 1n49D-2kfkB:23.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2plc | PHOSPHATIDYLINOSITOL-SPECIFICPHOSPHOLIPASE C (Listeriamonocytogenes) |
PF00388(PI-PLC-X) | 4 | ASP A 229GLY A 273ILE A 41ILE A 162 | None | 0.93A | 1n49D-2plcA:undetectable | 1n49D-2plcA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pun | METHYLTHIORIBOSEKINASE (Bacillussubtilis) |
PF01636(APH) | 4 | ASP A 250GLY A 39ILE A 38ILE A 122 | MG A 401 ( 2.8A)ACP A 999 ( 4.1A)NoneACP A 999 (-4.5A) | 0.88A | 1n49D-2punA:undetectable | 1n49D-2punA:14.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pwz | MALATE DEHYDROGENASE (Escherichiacoli) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ASN A 94GLY A 10ILE A 12ILE A 97 | None | 0.93A | 1n49D-2pwzA:undetectable | 1n49D-2pwzA:16.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qvl | DIACYLGLYCEROLKINASE DGKB (Staphylococcusaureus) |
PF00781(DAGK_cat) | 4 | ASP A 290GLY A 88ILE A 63ILE A 78 | None | 0.77A | 1n49D-2qvlA:undetectable | 1n49D-2qvlA:15.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29GLY A 49ILE A 50ILE A 84 | AB1 A 501 ( 3.3A)AB1 A 501 (-3.5A)AB1 A 501 (-3.8A)AB1 A 501 ( 4.2A) | 0.51A | 1n49D-2rkfA:20.4 | 1n49D-2rkfA:83.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2rkf | PROTEASE RETROPEPSIN (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29ILE A 50PRO A 81ILE A 84 | AB1 A 501 ( 3.3A)AB1 A 501 (-3.8A)AB1 A 501 (-4.2A)AB1 A 501 ( 4.2A) | 0.46A | 1n49D-2rkfA:20.4 | 1n49D-2rkfA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2voy | CATION-TRANSPORTINGATPASESARCOPLASMIC/ENDOPLASMIC RETICULUMCALCIUM ATPASE 1 (Archaeoglobusfulgidus;Oryctolaguscuniculus) |
PF00122(E1-E2_ATPase)PF00702(Hydrolase) | 4 | ASP I 647GLY I 619ILE I 620ILE H 332 | None | 0.85A | 1n49D-2voyI:undetectable | 1n49D-2voyI:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w37 | ORNITHINECARBAMOYLTRANSFERASE, CATABOLIC (Lactobacillushilgardii) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | ASP A 147GLY A 181ILE A 183ILE A 30 | None | 0.90A | 1n49D-2w37A:undetectable | 1n49D-2w37A:13.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yv7 | CG10997-PA (Drosophilamelanogaster) |
no annotation | 4 | ASP A 49GLY A 110PRO A 21ILE A 23 | None | 0.83A | 1n49D-2yv7A:undetectable | 1n49D-2yv7A:17.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3a9s | D-ARABINOSEISOMERASE (Aeribacilluspallidus) |
PF02952(Fucose_iso_C)PF07881(Fucose_iso_N1)PF07882(Fucose_iso_N2) | 4 | ASP A 486GLY A 386PRO A 373ILE A 392 | None | 0.94A | 1n49D-3a9sA:undetectable | 1n49D-3a9sA:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3anx | SPERMIDINE SYNTHASE (Thermusthermophilus) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | ASP A 140GLY A 85ILE A 83ILE A 138 | MTA A 315 (-3.9A)MTA A 315 (-3.2A)NoneNone | 0.94A | 1n49D-3anxA:undetectable | 1n49D-3anxA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dgz | THIOREDOXINREDUCTASE 2 (Mus musculus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | GLY A 172ILE A 173PRO A 159ILE A 283 | NoneNoneNoneNA7 A 501 (-3.5A) | 0.81A | 1n49D-3dgzA:undetectable | 1n49D-3dgzA:13.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh9 | THIOREDOXINREDUCTASE 1 (Drosophilamelanogaster) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | GLY A 174ILE A 175PRO A 162ILE A 285 | None | 0.82A | 1n49D-3dh9A:undetectable | 1n49D-3dh9A:11.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fd0 | PUTATIVECYSTATHIONINEBETA-LYASE INVOLVEDIN ALUMINUMRESISTANCE (Listeriainnocua) |
PF06838(Met_gamma_lyase) | 4 | ASP A 136GLY A 163ILE A 164ILE A 155 | NoneNoneNoneEDO A 424 (-4.2A) | 0.89A | 1n49D-3fd0A:undetectable | 1n49D-3fd0A:12.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNIT B (Sulfolobussolfataricus) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | ASP B 907GLY B 986PRO B 912ILE B 909 | None | 0.88A | 1n49D-3hkzB:undetectable | 1n49D-3hkzB:7.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3if2 | AMINOTRANSFERASE (Psychrobacterarcticus) |
PF00155(Aminotran_1_2) | 4 | GLY A 37ILE A 392PRO A 217ILE A 155 | None | 0.73A | 1n49D-3if2A:undetectable | 1n49D-3if2A:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iv3 | TAGATOSE1,6-DIPHOSPHATEALDOLASE 2 (Streptococcusmutans) |
PF01791(DeoC) | 4 | ASP A 157GLY A 200ILE A 201ILE A 113 | NoneEDO A 331 ( 3.7A)NoneNone | 0.72A | 1n49D-3iv3A:undetectable | 1n49D-3iv3A:13.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jwp | TRANSCRIPTIONALREGULATORY PROTEINSIR2 HOMOLOGUE (Plasmodiumfalciparum) |
PF02146(SIR2) | 4 | ASP A 109GLY A 125ILE A 171ILE A 73 | None | 0.93A | 1n49D-3jwpA:undetectable | 1n49D-3jwpA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k6q | PUTATIVE LIGANDBINDING PROTEIN (Syntrophomonaswolfei) |
PF12910(PHD_like) | 4 | ASP A 89GLY A 65ILE A 63ILE A 133 | None | 0.87A | 1n49D-3k6qA:undetectable | 1n49D-3k6qA:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kum | DIPEPTIDE EPIMERASE (Enterococcusfaecalis) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 4 | ASP A 108GLY A 300ILE A 301ILE A 271 | None | 0.88A | 1n49D-3kumA:undetectable | 1n49D-3kumA:20.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29GLY A 49ILE A 50ILE A 84 | None | 0.42A | 1n49D-3mwsA:19.6 | 1n49D-3mwsA:74.75 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3mws | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29ILE A 50PRO A 81ILE A 84 | None | 0.61A | 1n49D-3mwsA:19.6 | 1n49D-3mwsA:74.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o4v | MTA/SAH NUCLEOSIDASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 4 | ASN A 73GLY A 51ILE A 50ILE A 178 | NoneNone4CT A 233 (-3.7A)None | 0.89A | 1n49D-3o4vA:undetectable | 1n49D-3o4vA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3obi | FORMYLTETRAHYDROFOLATE DEFORMYLASE (Rhodopseudomonaspalustris) |
PF00551(Formyl_trans_N) | 4 | ASP A 236GLY A 219ILE A 218ILE A 193 | None | 0.82A | 1n49D-3obiA:undetectable | 1n49D-3obiA:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r75 | ANTHRANILATE/PARA-AMINOBENZOATESYNTHASES COMPONENTI (Burkholderialata) |
PF00117(GATase)PF00425(Chorismate_bind) | 4 | ASP A 581GLY A 537ILE A 538ILE A 516 | None | 0.62A | 1n49D-3r75A:undetectable | 1n49D-3r75A:10.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3swn | U6 SNRNA-ASSOCIATEDSM-LIKE PROTEIN LSM5 (Schizosaccharomycespombe) |
PF01423(LSM) | 4 | ASP A 46GLY A 16ILE A 15PRO A 75 | None | 0.78A | 1n49D-3swnA:undetectable | 1n49D-3swnA:24.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29GLY A 49ILE A 50ILE A 84 | 017 A 201 (-3.3A)017 A 201 (-3.0A)017 A 201 (-3.3A)017 A 201 (-4.7A) | 0.49A | 1n49D-3ttpA:19.4 | 1n49D-3ttpA:77.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ttp | HIV-1 PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 4 | ASP A 29GLY A 49PRO A 81ILE A 84 | 017 A 201 (-3.3A)017 A 201 (-3.0A)017 A 201 (-4.1A)017 A 201 (-4.7A) | 0.51A | 1n49D-3ttpA:19.4 | 1n49D-3ttpA:77.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aef | NEOPULLULANASE(ALPHA-AMYLASE II) (Pyrococcusfuriosus) |
PF00128(Alpha-amylase)PF02903(Alpha-amylase_N)PF16561(AMPK1_CBM) | 4 | GLY A 452ILE A 435PRO A 201ILE A 205 | None | 0.82A | 1n49D-4aefA:undetectable | 1n49D-4aefA:10.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bof | ARGININE DEIMINASE (Streptococcuspyogenes) |
PF02274(Amidinotransf) | 4 | ASN A 178ASP A 212ILE A 252ILE A 219 | None | 0.94A | 1n49D-4bofA:undetectable | 1n49D-4bofA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bv6 | APOPTOSIS-INDUCINGFACTOR 1,MITOCHONDRIAL (Homo sapiens) |
PF07992(Pyr_redox_2)PF14721(AIF_C) | 4 | GLY A 575ILE A 576PRO A 345ILE A 343 | None | 0.72A | 1n49D-4bv6A:undetectable | 1n49D-4bv6A:13.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4emk | U6 SNRNA-ASSOCIATEDSM-LIKE PROTEIN LSM5 (Schizosaccharomycespombe) |
PF01423(LSM) | 4 | ASP A 46GLY A 16ILE A 15PRO A 75 | None | 0.71A | 1n49D-4emkA:undetectable | 1n49D-4emkA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eyz | CELLULOSOME-RELATEDPROTEIN MODULE FROMRUMINOCOCCUSFLAVEFACIENS THATRESEMBLESPAPAIN-LIKE CYSTEINEPEPTIDASES (Ruminococcusflavefaciens) |
no annotation | 4 | ASP A 49GLY A 190ILE A 218ILE A 38 | None | 0.92A | 1n49D-4eyzA:undetectable | 1n49D-4eyzA:15.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6x | THIAZOLINEOXIDASE/SUBTILISIN-LIKE PROTEASE (Prochlorondidemni) |
PF00082(Peptidase_S8) | 4 | ASN A 645GLY A 628PRO A 787ILE A 546 | None | 0.91A | 1n49D-4h6xA:undetectable | 1n49D-4h6xA:15.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hdj | OUTER MEMBRANEPROTEIN ASSEMBLYFACTOR BAMB (Pseudomonasaeruginosa) |
PF13360(PQQ_2) | 4 | ASP A 147GLY A 160PRO A 187ILE A 189 | None | 0.94A | 1n49D-4hdjA:undetectable | 1n49D-4hdjA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ic5 | PROTEASE DO-LIKE 5,CHLOROPLASTIC (Arabidopsisthaliana) |
PF13365(Trypsin_2) | 4 | ASN A 281GLY A 234ILE A 233ILE A 261 | None | 0.78A | 1n49D-4ic5A:undetectable | 1n49D-4ic5A:17.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ixu | ARGINASE-2,MITOCHONDRIAL (Homo sapiens) |
PF00491(Arginase) | 4 | ASP A 256GLY A 276ILE A 279ILE A 252 | None | 0.94A | 1n49D-4ixuA:undetectable | 1n49D-4ixuA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jc5 | TRANSMEMBRANEPROTEIN 173 (Mus musculus) |
PF15009(TMEM173) | 4 | GLY A 165ILE A 164PRO A 172ILE A 229 | None | 0.92A | 1n49D-4jc5A:undetectable | 1n49D-4jc5A:18.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9a | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.1393C (Streptococcusmutans) |
no annotation | 4 | ASN A 237GLY A 123ILE A 122ILE A 212 | None | 0.94A | 1n49D-4l9aA:undetectable | 1n49D-4l9aA:14.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4njv | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | RIT A 500 (-3.2A)RIT A 500 (-3.4A)RIT A 500 (-4.3A)RIT A 500 (-3.9A)RIT A 500 (-4.3A) | 0.48A | 1n49D-4njvA:20.2 | 1n49D-4njvA:83.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ogz | PUTATIVEALPHA-GALACTOSIDASE/MELIBIASE (Bacteroidesfragilis) |
PF10632(He_PIG_assoc)PF16499(Melibiase_2)PF17450(Melibiase_2_C) | 4 | ASN A 131GLY A 318ILE A 319ILE A 355 | None | 0.83A | 1n49D-4ogzA:undetectable | 1n49D-4ogzA:12.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pe5 | GLUTAMATE RECEPTORIONOTROPIC, NMDA 2B (Rattusnorvegicus) |
PF00060(Lig_chan)PF01094(ANF_receptor)PF10613(Lig_chan-Glu_bd) | 4 | ASP B 306ILE B 37PRO B 317ILE B 314 | None | 0.91A | 1n49D-4pe5B:undetectable | 1n49D-4pe5B:7.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3r | ARGINASE (Schistosomamansoni) |
PF00491(Arginase) | 4 | ASP A 267GLY A 287ILE A 290ILE A 263 | None | 0.90A | 1n49D-4q3rA:undetectable | 1n49D-4q3rA:15.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qvu | UNCHARACTERIZEDPROTEIN (Bacillus cereus) |
PF16285(DUF4931) | 4 | ASN A 169ASP A 159GLY A 164ILE A 163 | None | 0.79A | 1n49D-4qvuA:undetectable | 1n49D-4qvuA:19.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r3u | 2-HYDROXYISOBUTYRYL-COA MUTASE LARGESUBUNIT (Aquincolatertiaricarbonis) |
PF01642(MM_CoA_mutase) | 4 | GLY A 551ILE A 552PRO A 214ILE A 212 | None | 0.87A | 1n49D-4r3uA:undetectable | 1n49D-4r3uA:9.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rsx | TYPE III EFFECTORHOPA1 (Pseudomonassyringae groupgenomosp. 3) |
no annotation | 4 | ASP A 278GLY A 265ILE A 221ILE A 238 | None | 0.81A | 1n49D-4rsxA:undetectable | 1n49D-4rsxA:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4w6z | ALCOHOLDEHYDROGENASE 1 (Saccharomycescerevisiae) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | ASP A 220GLY A 199ILE A 175ILE A 227 | None | 0.94A | 1n49D-4w6zA:undetectable | 1n49D-4w6zA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5af7 | ACYL-COADEHYDROGENASE (Advenellamimigardefordensis) |
PF00441(Acyl-CoA_dh_1)PF02770(Acyl-CoA_dh_M)PF02771(Acyl-CoA_dh_N) | 4 | ASP A 67GLY A 51ILE A 94ILE A 72 | None | 0.94A | 1n49D-5af7A:undetectable | 1n49D-5af7A:14.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bn4 | NEQ263V-TYPE ATP SYNTHASEALPHA CHAIN (Nanoarchaeumequitans) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N)PF16886(ATP-synt_ab_Xtn) | 4 | GLY A 82ILE A 283PRO B 101ILE A 90 | None | 0.94A | 1n49D-5bn4A:undetectable | 1n49D-5bn4A:9.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d86 | PROBABLE SIDEROPHOREBIOSYNTHESIS PROTEINSBNA (Staphylococcusaureus) |
PF00291(PALP) | 4 | ASP A 250GLY A 257ILE A 277ILE A 229 | None | 0.77A | 1n49D-5d86A:undetectable | 1n49D-5d86A:15.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5enz | UDP-GLCNAC2-EPIMERASE (Staphylococcusaureus) |
PF02350(Epimerase_2) | 4 | ASN A 346GLY A 284ILE A 285ILE A 175 | NoneUDP A 401 (-3.5A)NoneNone | 0.78A | 1n49D-5enzA:undetectable | 1n49D-5enzA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fva | NUCLEOPROTEIN (Sandfly feverNaplesphlebovirus) |
PF05733(Tenui_N) | 4 | ASN A 28GLY A 157ILE A 158PRO A 37 | None | 0.93A | 1n49D-5fvaA:undetectable | 1n49D-5fvaA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikj | CRYPTIC LOCIREGULATOR 2CRYPTIC LOCIREGULATOR PROTEIN 1 (Schizosaccharomycespombe) |
PF10383(Clr2)PF16761(Clr2_transil)no annotation | 4 | ASP A 223GLY A 370PRO B1221ILE B1225 | None | 0.62A | 1n49D-5ikjA:undetectable | 1n49D-5ikjA:10.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jr9 | NEQ131 (Nanoarchaeumequitans) |
PF01997(Translin) | 4 | ASP B 167GLY B 116ILE B 115ILE B 172 | None | 0.91A | 1n49D-5jr9B:undetectable | 1n49D-5jr9B:16.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kf7 | BIFUNCTIONAL PROTEINPUTA (Sinorhizobiummeliloti) |
PF00171(Aldedh)PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 4 | ASP A 221GLY A 261ILE A 301ILE A 201 | None | 0.88A | 1n49D-5kf7A:undetectable | 1n49D-5kf7A:6.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8j | DIVALENT METALCATION TRANSPORTERMNTH (Eremococcuscoleocola) |
PF01566(Nramp) | 4 | ASP A 18GLY A 166ILE A 165ILE A 349 | None | 0.94A | 1n49D-5m8jA:undetectable | 1n49D-5m8jA:12.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mju | EXCITATORY AMINOACID TRANSPORTER1,NEUTRAL AMINO ACIDTRANSPORTERB(0),EXCITATORYAMINO ACIDTRANSPORTER 1 (Homo sapiens) |
PF00375(SDF) | 4 | ASP A 174GLY A 422ILE A 423ILE A 433 | None | 0.74A | 1n49D-5mjuA:undetectable | 1n49D-5mjuA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5msx | PUTATIVEENDO-1,4-BETA-XYLANASE (Bacteroidesthetaiotaomicron) |
PF00754(F5_F8_type_C)PF04616(Glyco_hydro_43) | 4 | ASP A 374GLY A 453ILE A 454ILE A 334 | None | 0.85A | 1n49D-5msxA:undetectable | 1n49D-5msxA:13.35 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t2z | PROTEASE (Humanimmunodeficiencyvirus 1) |
PF00077(RVP) | 5 | ASP A 29GLY A 49ILE A 50PRO A 81ILE A 84 | None | 0.57A | 1n49D-5t2zA:19.5 | 1n49D-5t2zA:76.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u1o | GLUTATHIONEREDUCTASE (Vibrioparahaemolyticus) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 4 | GLY A 158ILE A 159PRO A 147ILE A 265 | None | 0.91A | 1n49D-5u1oA:undetectable | 1n49D-5u1oA:14.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xsx | CHITINASE (Thermococcuschitonophagus) |
no annotation | 4 | ASP A 487GLY A 484ILE A 483ILE A 700 | GOL A1004 (-3.5A)NoneNoneNone | 0.79A | 1n49D-5xsxA:undetectable | 1n49D-5xsxA:24.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bhc | PSEUDOPODIUM-ENRICHED ATYPICAL KINASE 1 (Homo sapiens) |
no annotation | 4 | GLY A1596ILE A1597PRO A1626ILE A1628 | None | 0.87A | 1n49D-6bhcA:undetectable | 1n49D-6bhcA:18.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bq6 | THERMOSPERMINESYNTHASE (Medicagotruncatula) |
no annotation | 4 | ASP A 160GLY A 106ILE A 104ILE A 158 | NoneTER A 402 ( 4.1A)NoneNone | 0.94A | 1n49D-6bq6A:undetectable | 1n49D-6bq6A:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ci9 | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]REDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 4 | ASP A 43GLY A 18ILE A 19ILE A 36 | NoneNAP A 301 (-3.2A)NAP A 301 (-3.8A)None | 0.94A | 1n49D-6ci9A:undetectable | 1n49D-6ci9A:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fhw | GLUCOAMYLASE P (Amorphothecaresinae) |
no annotation | 4 | ASP A 155GLY A 281ILE A 283ILE A 162 | None | 0.80A | 1n49D-6fhwA:undetectable | 1n49D-6fhwA:20.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6upj | HIV-2 PROTEASE (Humanimmunodeficiencyvirus 2) |
PF00077(RVP) | 4 | ASP A 29GLY A 48PRO A 81ILE A 84 | None | 0.93A | 1n49D-6upjA:18.0 | 1n49D-6upjA:47.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7mdh | PROTEIN (MALATEDEHYDROGENASE) (Sorghum bicolor) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | ASN A 147GLY A 53ILE A 129ILE A 150 | None | 0.88A | 1n49D-7mdhA:undetectable | 1n49D-7mdhA:15.14 |