SIMILAR PATTERNS OF AMINO ACIDS FOR 1N49_B_RITB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1axn ANNEXIN III

(Homo sapiens)
PF00191
(Annexin)
4 ASP A  71
ILE A  57
ALA A  31
ILE A  32
None
0.65A 1n49A-1axnA:
undetectable
1n49A-1axnA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)


(Serratia
marcescens)
PF00583
(Acetyltransf_1)
4 GLY A  25
ILE A  26
ALA A 125
ILE A 122
None
None
None
COA  A 300 ( 4.1A)
0.73A 1n49A-1bo4A:
undetectable
1n49A-1bo4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcu ALPHA-1,2-MANNOSIDAS
E


(Trichoderma
reesei)
PF01532
(Glyco_hydro_47)
5 ASP A 114
GLY A 108
ILE A  59
ALA A  65
ILE A  66
None
0.92A 1n49A-1hcuA:
undetectable
1n49A-1hcuA:
12.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ILE A  84
A79  A 800 (-2.7A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
A79  A 800 ( 3.4A)
A79  A 800 (-3.8A)
0.37A 1n49A-1hvcA:
14.0
1n49A-1hvcA:
47.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ILE A  84
A79  A 800 (-2.8A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
A79  A 800 ( 3.9A)
A79  A 800 (-3.6A)
0.61A 1n49A-1hvcA:
14.0
1n49A-1hvcA:
47.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqk CARBON MONOXIDE
DEHYDROGENASE


(Rhodospirillum
rubrum)
PF03063
(Prismane)
4 GLY A 513
ILE A 512
PRO A 243
ILE A 409
None
0.78A 1n49A-1jqkA:
undetectable
1n49A-1jqkA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE


(Bos taurus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
4 ASP A 638
GLY A 668
ILE A 666
ALA A 813
None
0.55A 1n49A-1n5xA:
undetectable
1n49A-1n5xA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE


(Leishmania
mexicana)
PF00342
(PGI)
4 ASN A 381
GLY A 556
ILE A 557
ILE A 377
None
0.66A 1n49A-1q50A:
undetectable
1n49A-1q50A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb8 WBPP

(Pseudomonas
aeruginosa)
PF01370
(Epimerase)
4 ASP A 235
ILE A 239
PRO A 212
ALA A 209
None
None
None
UD2  A 343 (-3.6A)
0.76A 1n49A-1sb8A:
undetectable
1n49A-1sb8A:
15.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus)
PF00077
(RVP)
5 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
0.36A 1n49A-1sivA:
18.6
1n49A-1sivA:
48.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE


(Bacillus
subtilis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A 109
GLY A 303
ALA A 278
ILE A 275
None
0.63A 1n49A-1tkkA:
undetectable
1n49A-1tkkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkk SIMILAR TO
CHLOROMUCONATE
CYCLOISOMERASE


(Bacillus
subtilis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A 109
GLY A 303
ILE A 304
ILE A 275
None
0.76A 1n49A-1tkkA:
undetectable
1n49A-1tkkA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttu LIN-12 AND GLP-1
TRANSCRIPTIONAL
REGULATOR


(Caenorhabditis
elegans)
PF01833
(TIG)
PF09270
(BTD)
PF09271
(LAG1-DNAbind)
4 GLY A 291
ILE A 292
PRO A 240
ILE A 219
None
0.75A 1n49A-1ttuA:
undetectable
1n49A-1ttuA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua2 CELL DIVISION
PROTEIN KINASE 7


(Homo sapiens)
PF00069
(Pkinase)
4 ASP A  79
GLY A  82
ALA A  59
ILE A  63
None
0.77A 1n49A-1ua2A:
undetectable
1n49A-1ua2A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ued P450 MONOOXYGENASE

(Amycolatopsis
orientalis)
PF00067
(p450)
4 ASP A 327
ILE A  67
PRO A 295
ALA A 294
None
None
HEM  A1430 (-4.6A)
None
0.68A 1n49A-1uedA:
undetectable
1n49A-1uedA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woq INORGANIC
POLYPHOSPHATE/ATP-GL
UCOMANNOKINASE


(Arthrobacter
sp. KM)
PF00480
(ROK)
4 ASN A 122
GLY A 152
ILE A 153
ALA A 127
BGC  A 290 (-3.2A)
BGC  A 290 ( 3.7A)
None
None
0.72A 1n49A-1woqA:
undetectable
1n49A-1woqA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wue MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN


(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A1110
GLY A1298
ALA A1273
ILE A1270
None
0.77A 1n49A-1wueA:
undetectable
1n49A-1wueA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bx7 DIHYDROOROTATE
DEHYDROGENASE


(Lactococcus
lactis)
PF01180
(DHO_dh)
4 GLY A 271
ILE A 270
ALA A 228
ILE A 224
FMN  A1312 (-3.4A)
None
None
FMN  A1312 ( 4.9A)
0.78A 1n49A-2bx7A:
undetectable
1n49A-2bx7A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzn GMP REDUCTASE 2

(Homo sapiens)
PF00478
(IMPDH)
4 ASP A 237
ILE A 154
ALA A  75
ILE A  51
None
0.69A 1n49A-2bznA:
undetectable
1n49A-2bznA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ch1 3-HYDROXYKYNURENINE
TRANSAMINASE


(Anopheles
gambiae)
PF00266
(Aminotran_5)
4 ASP A 127
GLY A 102
ILE A 103
ALA A 182
None
None
None
PLP  A1390 (-3.5A)
0.79A 1n49A-2ch1A:
undetectable
1n49A-2ch1A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1


(Homo sapiens)
PF02902
(Peptidase_C48)
4 GLY A 554
ILE A 555
ALA A 537
ILE A 528
None
0.68A 1n49A-2ckhA:
undetectable
1n49A-2ckhA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2czc GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Pyrococcus
horikoshii)
PF01113
(DapB_N)
PF02800
(Gp_dh_C)
4 ASN A 306
ASP A  85
GLY A  11
ALA A  20
None
None
NAD  A 501 (-3.3A)
None
0.77A 1n49A-2czcA:
undetectable
1n49A-2czcA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d16 HYPOTHETICAL PROTEIN
PH1918


(Pyrococcus
horikoshii)
PF04008
(Adenosine_kin)
4 ASP A   8
ILE A   4
ALA A  79
ILE A  77
None
0.72A 1n49A-2d16A:
undetectable
1n49A-2d16A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
4 ASP A 300
GLY A 364
PRO A 286
ALA A 288
None
0.79A 1n49A-2e0pA:
undetectable
1n49A-2e0pA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida)
PF11647
(MLD)
4 ASP A 739
GLY A 803
ILE A 802
ILE A 734
None
0.73A 1n49A-2ec5A:
undetectable
1n49A-2ec5A:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1


(Bos taurus)
PF00115
(COX1)
4 GLY A 250
ILE A 254
ALA A 276
ILE A 280
None
0.62A 1n49A-2eijA:
undetectable
1n49A-2eijA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4e ATFKBP42

(Arabidopsis
thaliana)
PF00254
(FKBP_C)
4 ASP A 148
GLY A 108
ILE A 111
ALA A 122
None
0.70A 1n49A-2f4eA:
undetectable
1n49A-2f4eA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis)
PF03401
(TctC)
4 ASN A 132
GLY A  45
PRO A 164
ALA A 165
None
0.79A 1n49A-2f5xA:
undetectable
1n49A-2f5xA:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE


(Equine
infectious
anemia virus)
PF00077
(RVP)
4 ASP A  29
GLY A  55
PRO A  86
ILE A  89
LP1  A 201 (-3.6A)
LP1  A 201 (-3.4A)
LP1  A 201 (-3.9A)
LP1  A 201 (-4.2A)
0.39A 1n49A-2fmbA:
15.2
1n49A-2fmbA:
32.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2if4 ATFKBP42

(Arabidopsis
thaliana)
PF00254
(FKBP_C)
PF13181
(TPR_8)
4 ASP A 148
GLY A 108
ILE A 111
ALA A 122
None
0.58A 1n49A-2if4A:
undetectable
1n49A-2if4A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbw 2,6-DIHYDROXY-PSEUDO
-OXYNICOTINE
HYDROLASE


(Paenarthrobacter
nicotinovorans)
PF06500
(DUF1100)
4 ASN A  50
ASP A  43
GLY A  94
ALA A  75
None
0.75A 1n49A-2jbwA:
undetectable
1n49A-2jbwA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpt EH DOMAIN-CONTAINING
PROTEIN-2


(Mus musculus)
PF00350
(Dynamin_N)
PF12763
(EF-hand_4)
PF16880
(EHD_N)
4 ASP A 198
GLY A 205
ALA A  64
ILE A 157
None
0.75A 1n49A-2qptA:
undetectable
1n49A-2qptA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB


(Staphylococcus
aureus)
PF00781
(DAGK_cat)
4 ASP A 290
GLY A  88
ILE A  63
ILE A  78
None
0.77A 1n49A-2qvlA:
undetectable
1n49A-2qvlA:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN


(Cytophaga
hutchinsonii)
PF07726
(AAA_3)
5 ASP A 147
GLY A 105
ILE A  88
ALA A 114
ILE A 112
None
1.28A 1n49A-2r44A:
undetectable
1n49A-2r44A:
16.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
6 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ALA A  82
ILE A  84
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
AB1  A 501 (-4.2A)
AB1  A 501 (-3.6A)
AB1  A 501 ( 4.2A)
0.44A 1n49A-2rkfA:
20.5
1n49A-2rkfA:
83.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 GLY A  48
PRO A  81
ALA A  82
ILE A  84
AB1  A 501 (-4.2A)
AB1  A 501 (-4.2A)
AB1  A 501 (-3.6A)
AB1  A 501 ( 4.2A)
0.76A 1n49A-2rkfA:
20.5
1n49A-2rkfA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vvr RIBOSE-5-PHOSPHATE
ISOMERASE B


(Escherichia
coli)
PF02502
(LacAB_rpiB)
4 ASP A  42
GLY A  71
ILE A  74
ALA A  51
None
0.63A 1n49A-2vvrA:
undetectable
1n49A-2vvrA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR


(Klebsiella
pneumoniae)
PF04198
(Sugar-bind)
PF13936
(HTH_38)
4 GLY A 293
ILE A 251
PRO A 215
ALA A 216
None
0.72A 1n49A-2w48A:
undetectable
1n49A-2w48A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB


(Salmonella
enterica)
PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C)
4 GLY A 327
ILE A  45
ALA A 282
ILE A 278
None
0.63A 1n49A-2wnwA:
undetectable
1n49A-2wnwA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzo REGULATOR OF
NONSENSE TRANSCRIPTS
1


(Homo sapiens)
PF04851
(ResIII)
PF13086
(AAA_11)
PF13087
(AAA_12)
4 GLY A 791
ILE A 792
ALA A 828
ILE A 525
None
None
U  D   4 ( 3.8A)
None
0.75A 1n49A-2xzoA:
undetectable
1n49A-2xzoA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yp6 THIOREDOXIN FAMILY
PROTEIN


(Streptococcus
pneumoniae)
PF00578
(AhpC-TSA)
4 ILE A 149
PRO A  50
ALA A  49
ILE A 164
None
0.78A 1n49A-2yp6A:
undetectable
1n49A-2yp6A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyy GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE


(Methanocaldococcus
jannaschii)
PF01113
(DapB_N)
PF02800
(Gp_dh_C)
4 ASN A 315
ASP A  87
GLY A  11
ALA A  20
None
None
NAP  A2001 (-3.2A)
None
0.77A 1n49A-2yyyA:
undetectable
1n49A-2yyyA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqp PROBABLE SECDF
PROTEIN-EXPORT
MEMBRANE PROTEIN


(Thermus
thermophilus)
PF02355
(SecD_SecF)
PF07549
(Sec_GG)
4 GLY A 429
ILE A 431
ALA A 362
ILE A 363
None
0.75A 1n49A-3aqpA:
undetectable
1n49A-3aqpA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bf0 PROTEASE 4

(Escherichia
coli)
PF01343
(Peptidase_S49)
4 GLY A 411
PRO A 417
ALA A 418
ILE A 421
None
0.73A 1n49A-3bf0A:
undetectable
1n49A-3bf0A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron)
PF07980
(SusD_RagB)
4 GLY A 458
ILE A 460
ALA A 250
ILE A 254
None
0.71A 1n49A-3ckbA:
undetectable
1n49A-3ckbA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 322
GLY A  94
PRO A 291
ALA A 292
None
0.75A 1n49A-3dfhA:
undetectable
1n49A-3dfhA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfh MANDELATE RACEMASE

(Vibrionales
bacterium
SWAT-3)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A 101
GLY A 318
ALA A 292
ILE A 289
None
0.75A 1n49A-3dfhA:
undetectable
1n49A-3dfhA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewd ADENOSINE DEAMINASE

(Plasmodium
vivax)
PF00962
(A_deaminase)
5 ASP A 184
GLY A 171
ILE A 170
ALA A 134
ILE A 141
None
1.26A 1n49A-3ewdA:
undetectable
1n49A-3ewdA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hee RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
4 ASP A  41
GLY A  70
ILE A  73
ALA A  50
None
R5P  A 651 (-3.3A)
None
None
0.65A 1n49A-3heeA:
undetectable
1n49A-3heeA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igh UNCHARACTERIZED
METAL-DEPENDENT
HYDROLASE


(Pyrococcus
horikoshii)
PF07969
(Amidohydro_3)
4 GLY X 121
ILE X 147
ALA X 188
ILE X 192
None
0.79A 1n49A-3ighX:
undetectable
1n49A-3ighX:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8c RIBOSE 5-PHOSPHATE
ISOMERASE


(Trypanosoma
cruzi)
PF02502
(LacAB_rpiB)
4 ASP A  45
GLY A  74
ILE A  77
ALA A  54
None
RES  A 160 (-3.4A)
None
None
0.72A 1n49A-3k8cA:
undetectable
1n49A-3k8cA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kum DIPEPTIDE EPIMERASE

(Enterococcus
faecalis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A 108
GLY A 300
ALA A 274
ILE A 271
None
0.66A 1n49A-3kumA:
undetectable
1n49A-3kumA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1p RIBOSE 5-PHOSPHATE
ISOMERASE


(Trypanosoma
cruzi)
PF02502
(LacAB_rpiB)
4 ASP A  45
GLY A  74
ILE A  77
ALA A  54
None
0.74A 1n49A-3m1pA:
undetectable
1n49A-3m1pA:
19.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
0.46A 1n49A-3mwsA:
19.7
1n49A-3mwsA:
74.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfe SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Legionella
pneumophila)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
4 GLY A 211
ILE A 372
ALA A 357
ILE A 245
None
0.79A 1n49A-3pfeA:
undetectable
1n49A-3pfeA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ph3 RIBOSE-5-PHOSPHATE
ISOMERASE


(Ruminiclostridium
thermocellum)
PF02502
(LacAB_rpiB)
4 ASP A  41
GLY A  70
ILE A  73
ALA A  50
None
RB5  A 150 (-3.5A)
None
None
0.67A 1n49A-3ph3A:
undetectable
1n49A-3ph3A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4d POSSIBLE
CHLOROMUCONATE
CYCLOISOMERASE
MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY


(Cytophaga
hutchinsonii)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A 108
GLY A 300
ALA A 275
ILE A 272
None
0.72A 1n49A-3q4dA:
undetectable
1n49A-3q4dA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qtg PYRUVATE KINASE

(Pyrobaculum
aerophilum)
PF00224
(PK)
PF02887
(PK_C)
4 ASP A  43
ILE A 284
ALA A 201
ILE A  78
None
0.70A 1n49A-3qtgA:
undetectable
1n49A-3qtgA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r11 ENZYME OF ENOLASE
SUPERFAMILY


(Francisella
philomiragia)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASP A 111
GLY A 304
ALA A 279
ILE A 276
None
0.76A 1n49A-3r11A:
undetectable
1n49A-3r11A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I


(Burkholderia
lata)
PF00117
(GATase)
PF00425
(Chorismate_bind)
4 ASP A 581
GLY A 537
ILE A 538
ILE A 516
None
0.59A 1n49A-3r75A:
undetectable
1n49A-3r75A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E


(Bos taurus)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
4 ASP C 638
GLY C 668
ILE C 666
ALA C 813
None
0.74A 1n49A-3sr6C:
undetectable
1n49A-3sr6C:
10.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ASP A  29
GLY A  49
ILE A  50
ALA A  82
017  A 201 (-3.5A)
017  A 201 (-4.0A)
017  A 201 (-3.3A)
SO4  A 101 (-3.5A)
0.57A 1n49A-3t3cA:
18.4
1n49A-3t3cA:
76.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
4 ASP A  29
GLY A  49
PRO A  81
ALA A  82
017  A 201 (-3.5A)
017  A 201 (-4.0A)
None
SO4  A 101 (-3.5A)
0.70A 1n49A-3t3cA:
18.4
1n49A-3t3cA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqd 3-DEOXY-MANNO-OCTULO
SONATE
CYTIDYLYLTRANSFERASE


(Coxiella
burnetii)
PF02348
(CTP_transf_3)
4 ASP A 100
ILE A   6
ALA A  58
ILE A  30
None
0.76A 1n49A-3tqdA:
undetectable
1n49A-3tqdA:
17.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ILE A  84
017  A 201 (-3.3A)
017  A 201 (-3.0A)
017  A 201 (-3.3A)
017  A 201 (-4.1A)
017  A 201 (-4.7A)
0.51A 1n49A-3ttpA:
19.3
1n49A-3ttpA:
77.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aef NEOPULLULANASE
(ALPHA-AMYLASE II)


(Pyrococcus
furiosus)
PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16561
(AMPK1_CBM)
4 GLY A 452
ILE A 435
PRO A 201
ILE A 205
None
0.78A 1n49A-4aefA:
undetectable
1n49A-4aefA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2i HERA

(Sulfolobus
solfataricus)
PF01935
(DUF87)
PF05872
(DUF853)
PF09378
(HAS-barrel)
4 GLY A 449
ILE A 451
ALA A 445
ILE A 410
None
0.78A 1n49A-4d2iA:
undetectable
1n49A-4d2iA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE


(Acinetobacter
baumannii)
PF00132
(Hexapep)
PF13720
(Acetyltransf_11)
4 ASP A  22
ILE A  61
ALA A  11
ILE A   7
None
0.79A 1n49A-4e6uA:
undetectable
1n49A-4e6uA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ASN A 320
GLY A  92
PRO A 289
ALA A 290
None
0.79A 1n49A-4gisA:
undetectable
1n49A-4gisA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gtn ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE


(Acinetobacter
sp. ADP1)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
4 GLY A  59
ILE A  58
ALA A  26
ILE A  30
None
0.60A 1n49A-4gtnA:
undetectable
1n49A-4gtnA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB


(Pseudomonas
aeruginosa)
PF13360
(PQQ_2)
4 ASP A 147
GLY A 160
PRO A 187
ILE A 189
None
0.79A 1n49A-4hdjA:
undetectable
1n49A-4hdjA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hdj OUTER MEMBRANE
PROTEIN ASSEMBLY
FACTOR BAMB


(Pseudomonas
aeruginosa)
PF13360
(PQQ_2)
4 GLY A 160
ILE A 159
PRO A 187
ALA A 196
None
0.78A 1n49A-4hdjA:
undetectable
1n49A-4hdjA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Dickeya
paradisiaca)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 GLY A  62
ILE A  61
ALA A  75
ILE A  71
None
0.75A 1n49A-4ihcA:
undetectable
1n49A-4ihcA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgb PUTATIVE EXPORTED
PROTEIN


(Burkholderia
pseudomallei)
PF13460
(NAD_binding_10)
4 GLY A  14
PRO A 158
ALA A 157
ILE A 156
None
0.77A 1n49A-4jgbA:
undetectable
1n49A-4jgbA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE


(Zymomonas
mobilis)
PF00348
(polyprenyl_synt)
4 GLY A 196
ILE A 198
ALA A  74
ILE A  75
None
0.78A 1n49A-4kkmA:
undetectable
1n49A-4kkmA:
19.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ILE A  84
RIT  A 500 (-3.2A)
RIT  A 500 (-3.4A)
RIT  A 500 (-4.3A)
RIT  A 500 (-3.9A)
RIT  A 500 (-4.3A)
0.45A 1n49A-4njvA:
20.3
1n49A-4njvA:
83.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii)
PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
4 GLY A 106
ILE A 110
ALA A  60
ILE A  46
None
0.74A 1n49A-4p52A:
undetectable
1n49A-4p52A:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C)
no annotation 4 ASN A 340
GLY A 483
ALA A 378
ILE A 272
None
0.75A 1n49A-4qnlA:
undetectable
1n49A-4qnlA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT


(Aquincola
tertiaricarbonis)
PF01642
(MM_CoA_mutase)
4 GLY A 551
ILE A 552
PRO A 214
ILE A 212
None
0.77A 1n49A-4r3uA:
undetectable
1n49A-4r3uA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0n PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Streptobacillus
moniliformis)
PF13407
(Peripla_BP_4)
4 ASP A 325
GLY A 321
ALA A 265
ILE A 269
None
0.77A 1n49A-4z0nA:
undetectable
1n49A-4z0nA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9d PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA


(Escherichia
coli)
PF02917
(Pertussis_S1)
5 ASN A  85
GLY A 127
ILE A 130
ALA A 121
ILE A  87
None
1.11A 1n49A-4z9dA:
undetectable
1n49A-4z9dA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgq EUKARYOTIC
TRANSLATION
INITIATION FACTOR 2
SUBUNIT GAMMA


(Saccharomyces
cerevisiae)
PF09173
(eIF2_C)
4 GLY B 513
ILE B 512
ALA B 483
ILE B 432
None
0.71A 1n49A-4zgqB:
undetectable
1n49A-4zgqB:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bqn BOTULINUM NEUROTOXIN
TYPE D,BOTULINUM
NEUROTOXIN TYPE D


(Clostridium
botulinum)
PF01742
(Peptidase_M27)
PF07952
(Toxin_trans)
4 ASP A 397
GLY A 405
PRO A 419
ALA A 420
None
0.76A 1n49A-5bqnA:
undetectable
1n49A-5bqnA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyu CONSERVED MEMBRANE
PROTEIN


(Mycolicibacterium
smegmatis)
PF05108
(T7SS_ESX1_EccB)
4 GLY A 421
ILE A 422
PRO A 137
ILE A 133
None
0.75A 1n49A-5cyuA:
undetectable
1n49A-5cyuA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis)
PF00501
(AMP-binding)
4 ASP A 303
GLY A 330
ALA A 289
ILE A 264
None
0.64A 1n49A-5d6nA:
undetectable
1n49A-5d6nA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA


(Cupriavidus
necator)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
4 GLY A 233
ILE A 236
ALA A 110
ILE A 106
None
0.64A 1n49A-5dmhA:
undetectable
1n49A-5dmhA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis)
PF00501
(AMP-binding)
4 ASP A 303
GLY A 330
ALA A 289
ILE A 264
None
0.74A 1n49A-5ey8A:
undetectable
1n49A-5ey8A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fp2 FERRIC ENTEROBACTIN
RECEPTOR PIRA


(Pseudomonas
aeruginosa)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 ASN A 373
GLY A 145
ALA A 412
ILE A 410
None
0.73A 1n49A-5fp2A:
undetectable
1n49A-5fp2A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9f CRISPR SYSTEM
CASCADE SUBUNIT CASE


(Escherichia
coli)
PF08798
(CRISPR_assoc)
4 ILE K 123
PRO K  92
ALA K  90
ILE K 183
None
0.75A 1n49A-5h9fK:
undetectable
1n49A-5h9fK:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2t PERIODIC TRYPTOPHAN
PROTEIN 2


(Saccharomyces
cerevisiae)
PF00400
(WD40)
4 GLY A 116
ILE A 149
ALA A  60
ILE A  73
None
0.78A 1n49A-5i2tA:
undetectable
1n49A-5i2tA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1


(Schizosaccharomyces
pombe)
PF10383
(Clr2)
PF16761
(Clr2_transil)
no annotation
4 ASP A 223
GLY A 370
PRO B1221
ILE B1225
None
0.65A 1n49A-5ikjA:
undetectable
1n49A-5ikjA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j32 3-ISOPROPYLMALATE
DEHYDROGENASE 2,
CHLOROPLASTIC


(Arabidopsis
thaliana)
PF00180
(Iso_dh)
4 GLY A 302
ILE A 301
ALA A 113
ILE A  53
None
0.76A 1n49A-5j32A:
undetectable
1n49A-5j32A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7v GLYCOSIDE HYDROLASE

(Bacteroides
vulgatus)
PF13320
(DUF4091)
4 ASP A 379
ILE A 355
ALA A 359
ILE A 358
None
0.77A 1n49A-5l7vA:
undetectable
1n49A-5l7vA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1


(Homo sapiens)
PF00375
(SDF)
4 ASP A 174
GLY A 422
ILE A 423
ILE A 433
None
0.70A 1n49A-5mjuA:
undetectable
1n49A-5mjuA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sv0 BIOPOLYMER TRANSPORT
PROTEIN EXBB


(Escherichia
coli)
no annotation 4 GLY B 158
ILE B 157
ALA B 177
ILE B 174
None
0.75A 1n49A-5sv0B:
undetectable
1n49A-5sv0B:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1)
PF00077
(RVP)
5 ASP A  29
GLY A  49
ILE A  50
PRO A  81
ILE A  84
None
0.47A 1n49A-5t2zA:
19.4
1n49A-5t2zA:
76.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN


(Sulfolobus
acidocaldarius)
PF03458
(UPF0126)
4 GLY A  50
ILE A  51
ALA A  21
ILE A  17
None
0.77A 1n49A-5wueA:
undetectable
1n49A-5wueA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsx CHITINASE

(Thermococcus
chitonophagus)
no annotation 4 ASP A 487
GLY A 484
ILE A 483
ILE A 700
GOL  A1004 (-3.5A)
None
None
None
0.78A 1n49A-5xsxA:
undetectable
1n49A-5xsxA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aoo MALATE DEHYDROGENASE

(Haemophilus
influenzae)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
4 ASP A 150
GLY A 145
ILE A 116
ALA A 235
None
0.75A 1n49A-6aooA:
undetectable
1n49A-6aooA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bz0 DIHYDROLIPOYL
DEHYDROGENASE


(Acinetobacter
baumannii)
no annotation 4 ASP A 425
GLY A 420
ILE A 419
ALA A 460
None
0.79A 1n49A-6bz0A:
undetectable
1n49A-6bz0A:
22.64