SIMILAR PATTERNS OF AMINO ACIDS FOR 1N3Z_A_ADNA126_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d5d RNASE S

(Bos taurus) 		PF00074
(RnaseA) 		5 ASN B  67
GLN B  69
ASN B  71
ALA B 109
VAL B 118
 None
 0.52A 1n3zA-1d5dB:
16.9		 1n3zA-1d5dB:
82.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eu1 DIMETHYL SULFOXIDE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 ALA A 759
ASN A 737
GLN A 440
ALA A 641
VAL A 639
 None
MGD  A1001 (-3.0A)
MGD  A1001 (-4.3A)
MGD  A1001 (-3.6A)
None
 1.47A 1n3zA-1eu1A:
0.0		 1n3zA-1eu1A:
8.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rra PROTEIN
(RIBONUCLEASE)

(Rattus
norvegicus) 		PF00074
(RnaseA) 		5 LYS A   7
ASN A  67
ASN A  71
ALA A 109
VAL A 118
 None
 0.62A 1n3zA-1rraA:
21.6		 1n3zA-1rraA:
66.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1srn RIBONUCLEASE A

(Bos taurus) 		PF00074
(RnaseA) 		5 ALA A   4
LYS A   7
ASN A  67
ASN A  71
ALA A 109
 None
 0.40A 1n3zA-1srnA:
19.4		 1n3zA-1srnA:
80.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zsq MYOTUBULARIN-RELATED
PROTEIN 2

(Homo sapiens) 		PF02893
(GRAM)
PF06602
(Myotub-related) 		5 GLN A 312
ASN A 310
ALA A 279
VAL A 406
HIS A 274
 None
 1.43A 1n3zA-1zsqA:
undetectable		 1n3zA-1zsqA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		5 ALA A  82
LYS A  85
ALA A  52
VAL A  83
HIS A  36
 None
 1.34A 1n3zA-2d4pA:
undetectable		 1n3zA-2d4pA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i05 DNA REPLICATION
TERMINUS
SITE-BINDING PROTEIN

(Escherichia
coli) 		PF05472
(Ter) 		5 LYS A  59
ASN A  64
GLN A  67
ALA A  36
VAL A  38
 None
 1.40A 1n3zA-2i05A:
undetectable		 1n3zA-2i05A:
16.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2rnf RIBONUCLEASE 4

(Homo sapiens) 		PF00074
(RnaseA) 		5 ASN A  66
ASN A  70
ALA A 106
VAL A 115
HIS A 116
 None
None
None
None
UM3  A 301 ( 4.9A)
 0.39A 1n3zA-2rnfA:
18.9		 1n3zA-2rnfA:
42.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvy CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY

(Streptococcus
mutans) 		PF02627
(CMD) 		5 ALA A  83
ASN A 164
ALA A  73
VAL A  82
HIS A  85
 None
None
None
None
BME  A 191 (-3.7A)
 1.49A 1n3zA-3lvyA:
undetectable		 1n3zA-3lvyA:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC

(Bos taurus) 		PF00074
(RnaseA) 		6 ALA A   4
LYS A   7
ASN A  67
ASN A  71
ALA A 109
VAL A 118
 None
 0.38A 1n3zA-3mx8A:
23.5		 1n3zA-3mx8A:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC

(Bos taurus) 		PF00074
(RnaseA) 		6 ALA A 132
ASN A 195
GLN A 197
ASN A 199
ALA A 237
VAL A 246
 SO4  A 257 (-3.4A)
None
None
None
None
None
 0.87A 1n3zA-3mx8A:
23.5		 1n3zA-3mx8A:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3mx8 RIBONUCLEASE
PANCREATIC, LINKER,
RIBONUCLEASE
PANCREATIC

(Bos taurus) 		PF00074
(RnaseA) 		6 ALA A 132
LYS A 135
ASN A 195
ASN A 199
ALA A 237
VAL A 246
 SO4  A 257 (-3.4A)
None
None
None
None
None
 0.39A 1n3zA-3mx8A:
23.5		 1n3zA-3mx8A:
42.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tsr RIBONUCLEASE
PANCREATIC

(Mus musculus) 		PF00074
(RnaseA) 		7 ALA A   5
LYS A   8
ASN A  68
ASN A  72
ALA A 110
VAL A 119
HIS A 120
 None
 0.51A 1n3zA-3tsrA:
23.6		 1n3zA-3tsrA:
67.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ar6 RIBONUCLEASE 4

(Sus scrofa) 		PF00074
(RnaseA) 		5 ASN A  66
ASN A  70
ALA A 106
VAL A 115
HIS A 116
 None
 0.30A 1n3zA-5ar6A:
19.2		 1n3zA-5ar6A:
44.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5arl RIBONUCLEASE 4

(Sus scrofa) 		PF00074
(RnaseA) 		5 ASN A  66
ASN A  70
ALA A 106
VAL A 115
HIS A 116
 None
None
None
None
DCM  A1120 (-3.3A)
 0.45A 1n3zA-5arlA:
19.3		 1n3zA-5arlA:
39.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cek TRIBBLES HOMOLOG 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 ALA A 329
GLN A 188
ALA A 192
VAL A 193
HIS A 195
 None
 1.24A 1n3zA-5cekA:
undetectable		 1n3zA-5cekA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
9rub RIBULOSE-1,5-BISPHOS
PHATE CARBOXYLASE

(Rhodospirillum
rubrum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 ALA A 177
LYS A 174
GLN A 219
ALA A 212
VAL A 211
 None
 1.47A 1n3zA-9rubA:
undetectable		 1n3zA-9rubA:
12.78