SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_D_VDYD1001_5

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		3 THR A 114
LEU A 118
VAL A 121
 None
 0.36A 1mz9E-1a0eA:
undetectable		 1mz9E-1a0eA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		3 THR A 212
LEU A 216
VAL A 219
 None
 0.65A 1mz9E-1a5cA:
undetectable		 1mz9E-1a5cA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 THR A 412
LEU A 413
VAL A 401
 None
 0.64A 1mz9E-1ao0A:
0.0		 1mz9E-1ao0A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 THR A 106
LEU A 110
VAL A 113
 None
 0.47A 1mz9E-1b4pA:
undetectable		 1mz9E-1b4pA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bct BACTERIORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		3 THR A 170
LEU A 174
VAL A 177
 None
 0.54A 1mz9E-1bctA:
1.8		 1mz9E-1bctA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg8 PROTEIN (HEMOGLOBIN)

(Dasyatis akajei) 		PF00042
(Globin) 		3 THR B  24
LEU B  28
VAL B  31
 None
 0.67A 1mz9E-1cg8B:
undetectable		 1mz9E-1cg8B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwp COAT PROTEIN

(Cowpea
chlorotic
mottle virus) 		PF01318
(Bromo_coat) 		3 THR A 146
LEU A  86
VAL A 178
 None
 0.68A 1mz9E-1cwpA:
undetectable		 1mz9E-1cwpA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 THR A  72
LEU A  76
VAL A  79
 MET  A 401 (-3.8A)
None
None
 0.65A 1mz9E-1d6sA:
undetectable		 1mz9E-1d6sA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 373
LEU A 377
VAL A 380
 None
 0.66A 1mz9E-1dcnA:
0.3		 1mz9E-1dcnA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxz ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Tetronarce
californica) 		PF02932
(Neur_chan_memb) 		3 THR A 254
LEU A 258
VAL A 261
 None
 0.34A 1mz9E-1dxzA:
2.8		 1mz9E-1dxzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e12 HALORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		3 THR A 198
LEU A 202
VAL A 205
 None
 0.58A 1mz9E-1e12A:
undetectable		 1mz9E-1e12A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		3 THR A  68
LEU A  72
VAL A  76
 None
 0.52A 1mz9E-1ei5A:
undetectable		 1mz9E-1ei5A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		3 THR A1205
LEU A1209
VAL A1212
 None
 0.67A 1mz9E-1fdjA:
undetectable		 1mz9E-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Escherichia
coli) 		PF01182
(Glucosamine_iso) 		3 THR A   8
LEU A   6
VAL A 238
 None
 0.66A 1mz9E-1fs5A:
undetectable		 1mz9E-1fs5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 THR A 278
LEU A 282
VAL A 285
 None
 0.21A 1mz9E-1fw8A:
undetectable		 1mz9E-1fw8A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 THR A 335
LEU A 323
VAL A 314
 None
 0.64A 1mz9E-1gq1A:
undetectable		 1mz9E-1gq1A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 371
LEU A 375
VAL A 378
 None
 0.62A 1mz9E-1i0aA:
undetectable		 1mz9E-1i0aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		3 THR A 255
LEU A 259
VAL A 262
 None
 0.59A 1mz9E-1icpA:
undetectable		 1mz9E-1icpA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		3 THR A 185
LEU A 189
VAL A 192
 None
 0.43A 1mz9E-1jdzA:
undetectable		 1mz9E-1jdzA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 THR A 135
LEU A 139
VAL A 142
 None
 0.55A 1mz9E-1kczA:
undetectable		 1mz9E-1kczA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		3 THR A 180
LEU A 177
VAL A 162
 None
 0.61A 1mz9E-1kplA:
undetectable		 1mz9E-1kplA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6n GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00540
(Gag_p17)
PF00607
(Gag_p24) 		3 THR A  81
LEU A  85
VAL A  88
 None
 0.61A 1mz9E-1l6nA:
undetectable		 1mz9E-1l6nA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		3 THR A 134
LEU A 133
VAL A 137
 None
 0.49A 1mz9E-1nmoA:
undetectable		 1mz9E-1nmoA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG

(Saccharomyces
cerevisiae) 		PF09201
(SRX) 		3 THR A 102
LEU A 106
VAL A 109
 None
 0.53A 1mz9E-1nrjA:
undetectable		 1mz9E-1nrjA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nww LIMONENE-1,2-EPOXIDE
HYDROLASE

(Rhodococcus
erythropolis) 		PF07858
(LEH) 		3 THR A  70
LEU A  74
VAL A  77
 None
HPN  A 900 ( 4.8A)
None
 0.47A 1mz9E-1nwwA:
undetectable		 1mz9E-1nwwA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 THR A 274
LEU A 278
VAL A 281
 None
 0.63A 1mz9E-1o2dA:
undetectable		 1mz9E-1o2dA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 THR A 104
LEU A 108
VAL A 111
 None
 0.68A 1mz9E-1orrA:
undetectable		 1mz9E-1orrA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox3 FIBRITIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 THR A  48
LEU A  52
VAL A  55
 None
 0.28A 1mz9E-1ox3A:
2.9		 1mz9E-1ox3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		3 THR A 450
LEU A 451
VAL A 481
 None
ADP  A1528 (-4.2A)
ADP  A1528 (-3.8A)
 0.66A 1mz9E-1q3sA:
undetectable		 1mz9E-1q3sA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		3 THR A 459
LEU A 463
VAL A 466
 None
 0.39A 1mz9E-1q3sA:
undetectable		 1mz9E-1q3sA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 THR A  65
LEU A  69
VAL A  72
 None
 0.38A 1mz9E-1q51A:
undetectable		 1mz9E-1q51A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 THR A  39
LEU A  76
VAL A  75
 None
 0.63A 1mz9E-1q5aA:
undetectable		 1mz9E-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 THR B 321
LEU B 325
VAL B 328
 None
 0.67A 1mz9E-1qh1B:
undetectable		 1mz9E-1qh1B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 THR A 349
LEU A 353
VAL A 356
 None
 0.28A 1mz9E-1qpgA:
undetectable		 1mz9E-1qpgA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		3 THR A  97
LEU A 101
VAL A 104
 PLP  A1227 (-3.8A)
None
None
 0.43A 1mz9E-1qz9A:
undetectable		 1mz9E-1qz9A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		3 THR A 135
LEU A 139
VAL A 142
 None
 0.22A 1mz9E-1r4nA:
undetectable		 1mz9E-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		3 THR A 233
LEU A 237
VAL A 240
 None
 0.66A 1mz9E-1r55A:
undetectable		 1mz9E-1r55A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		3 THR A 278
LEU A 282
VAL A 285
 None
 0.35A 1mz9E-1rtrA:
undetectable		 1mz9E-1rtrA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj5 CONSERVED
HYPOTHETICAL PROTEIN
TM0160

(Thermotoga
maritima) 		PF02577
(DNase-RNase) 		3 THR A  57
LEU A  61
VAL A  64
 None
 0.49A 1mz9E-1sj5A:
undetectable		 1mz9E-1sj5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 THR A  76
LEU A  80
VAL A  83
 None
 0.24A 1mz9E-1sqgA:
undetectable		 1mz9E-1sqgA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr2 PUTATIVE SENSOR-LIKE
HISTIDINE KINASE
YOJN

(Escherichia
coli) 		PF01627
(Hpt) 		3 THR A 840
LEU A 844
VAL A 847
 None
 0.60A 1mz9E-1sr2A:
undetectable		 1mz9E-1sr2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1

(Mus musculus) 		PF03036
(Perilipin) 		3 THR A 272
LEU A 276
VAL A 279
 None
 0.61A 1mz9E-1sziA:
2.1		 1mz9E-1sziA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t35 HYPOTHETICAL PROTEIN
YVDD, PUTATIVE
LYSINE DECARBOXYLASE

(Bacillus
subtilis) 		PF03641
(Lysine_decarbox) 		3 THR A 110
LEU A 114
VAL A 117
 SO4  A 192 (-3.6A)
None
None
 0.32A 1mz9E-1t35A:
undetectable		 1mz9E-1t35A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		3 THR A  29
LEU A 259
VAL A 206
 None
 0.61A 1mz9E-1t5eA:
undetectable		 1mz9E-1t5eA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		3 THR A 254
LEU A 258
VAL A 261
 None
 0.49A 1mz9E-1tisA:
undetectable		 1mz9E-1tisA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2m HISTONE-LIKE PROTEIN
HLP-1

(Escherichia
coli) 		PF03938
(OmpH) 		3 THR A 153
LEU A 157
VAL A 160
 None
 0.31A 1mz9E-1u2mA:
1.2		 1mz9E-1u2mA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		3 THR A 179
LEU A 183
VAL A 186
 None
 0.49A 1mz9E-1uazA:
undetectable		 1mz9E-1uazA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 THR A  35
LEU A  39
VAL A  42
 None
 0.45A 1mz9E-1ufaA:
undetectable		 1mz9E-1ufaA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 THR A  97
LEU A  49
VAL A  12
 None
 0.36A 1mz9E-1uiyA:
undetectable		 1mz9E-1uiyA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		3 THR A 285
LEU A 284
VAL A 278
 None
 0.60A 1mz9E-1vg0A:
undetectable		 1mz9E-1vg0A:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 THR A 457
LEU A 461
VAL A 464
 None
 0.30A 1mz9E-1w6jA:
undetectable		 1mz9E-1w6jA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 THR A 246
LEU A 250
VAL A 253
 None
 0.49A 1mz9E-1w9xA:
undetectable		 1mz9E-1w9xA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		3 THR A 652
LEU A 656
VAL A 659
 None
 0.54A 1mz9E-1wacA:
undetectable		 1mz9E-1wacA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		3 THR A 144
LEU A 148
VAL A 151
 PO4  A 501 (-3.9A)
None
None
 0.38A 1mz9E-1wekA:
undetectable		 1mz9E-1wekA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		3 THR A 122
LEU A 119
VAL A 127
 None
 0.66A 1mz9E-1wiwA:
undetectable		 1mz9E-1wiwA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkp FLOWERING LOCUS T
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		3 THR A  27
LEU A  28
VAL A 160
 SO4  A1001 (-3.6A)
None
None
 0.62A 1mz9E-1wkpA:
undetectable		 1mz9E-1wkpA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wps HUT OPERON POSITIVE
REGULATORY PROTEIN

(Bacillus
subtilis) 		PF09021
(HutP) 		3 THR A  79
LEU A  83
VAL A  86
 None
 0.46A 1mz9E-1wpsA:
undetectable		 1mz9E-1wpsA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 THR A 268
LEU A 267
VAL A 240
 None
 0.68A 1mz9E-1wwkA:
undetectable		 1mz9E-1wwkA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		3 THR A  37
LEU A  41
VAL A  44
 None
 0.48A 1mz9E-1wz9A:
undetectable		 1mz9E-1wz9A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1s RAS-RELATED PROTEIN
M-RAS

(Mus musculus) 		PF00071
(Ras) 		3 THR A 167
LEU A 171
VAL A 174
 None
 0.36A 1mz9E-1x1sA:
undetectable		 1mz9E-1x1sA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		3 THR A 226
LEU A 280
VAL A 261
 None
 0.62A 1mz9E-1xkdA:
undetectable		 1mz9E-1xkdA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y11 HYPOTHETICAL PROTEIN
RV1264/MT1302

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc)
PF16701
(Ad_Cy_reg) 		3 THR A 280
LEU A 284
VAL A 287
 None
 0.15A 1mz9E-1y11A:
undetectable		 1mz9E-1y11A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		3 THR A 160
LEU A 164
VAL A 167
 None
 0.62A 1mz9E-1y9uA:
undetectable		 1mz9E-1y9uA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		3 THR A 346
LEU A 350
VAL A 353
 None
 0.27A 1mz9E-1yhtA:
undetectable		 1mz9E-1yhtA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		3 THR A  85
LEU A  89
VAL A  92
 None
 0.35A 1mz9E-1yulA:
undetectable		 1mz9E-1yulA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		3 THR A 513
LEU A 517
VAL A 520
 None
 0.40A 1mz9E-1z7eA:
undetectable		 1mz9E-1z7eA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbd RABPHILIN-3A

(Rattus
norvegicus) 		PF00071
(Ras) 		3 THR A 175
LEU A 179
VAL A 182
 None
 0.30A 1mz9E-1zbdA:
undetectable		 1mz9E-1zbdA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		3 THR A 185
LEU A 189
VAL A 192
 None
 0.49A 1mz9E-1zc6A:
undetectable		 1mz9E-1zc6A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 THR A 457
LEU A 461
VAL A 464
 None
 0.59A 1mz9E-1zrzA:
undetectable		 1mz9E-1zrzA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS

(Escherichia
coli) 		PF05307
(Bundlin) 		3 THR A  41
LEU A  38
VAL A  71
 None
 0.65A 1mz9E-1zwtA:
undetectable		 1mz9E-1zwtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 THR A  51
LEU A 132
VAL A 127
 None
 0.64A 1mz9E-1zy9A:
undetectable		 1mz9E-1zy9A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		3 THR A 122
LEU A 126
VAL A 129
 SO4  A 600 (-3.6A)
None
None
 0.45A 1mz9E-2a33A:
undetectable		 1mz9E-2a33A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 THR B 325
LEU B 329
VAL B 332
 None
 0.66A 1mz9E-2afhB:
undetectable		 1mz9E-2afhB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		3 THR A 101
LEU A 105
VAL A 108
 None
 0.64A 1mz9E-2amlA:
undetectable		 1mz9E-2amlA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 THR A 132
LEU A 150
VAL A 164
 None
 0.64A 1mz9E-2b3oA:
undetectable		 1mz9E-2b3oA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 THR A 101
LEU A 105
VAL A 108
 None
 0.61A 1mz9E-2b8nA:
undetectable		 1mz9E-2b8nA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 3 THR A 270
LEU A 335
VAL A 306
 None
 0.46A 1mz9E-2bi0A:
undetectable		 1mz9E-2bi0A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		3 THR A 187
LEU A 184
VAL A 192
 None
 0.64A 1mz9E-2c1hA:
undetectable		 1mz9E-2c1hA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 THR A 332
LEU A 329
VAL A 284
 None
 0.60A 1mz9E-2c5aA:
undetectable		 1mz9E-2c5aA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		3 THR A 179
LEU A 244
VAL A 208
 None
 0.58A 1mz9E-2cbfA:
undetectable		 1mz9E-2cbfA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING

(Homo sapiens) 		PF00017
(SH2) 		3 THR A 106
LEU A 105
VAL A  90
 None
 0.66A 1mz9E-2cs0A:
undetectable		 1mz9E-2cs0A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 THR A 106
LEU A 110
VAL A 113
 None
 0.60A 1mz9E-2cukA:
undetectable		 1mz9E-2cukA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 THR A 156
LEU A 160
VAL A 163
 SO4  A1339 ( 4.3A)
None
None
 0.64A 1mz9E-2d2iA:
undetectable		 1mz9E-2d2iA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		3 THR A 255
LEU A 259
VAL A 262
 None
 0.46A 1mz9E-2d5wA:
undetectable		 1mz9E-2d5wA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 THR A 246
LEU A 250
VAL A 253
 None
 0.36A 1mz9E-2dieA:
undetectable		 1mz9E-2dieA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		3 THR A 127
LEU A 128
VAL A 134
 None
 0.59A 1mz9E-2dwcA:
undetectable		 1mz9E-2dwcA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2a PROTEIN (ENZYME IIA)

(Lactococcus
lactis) 		PF02255
(PTS_IIA) 		3 THR A  85
LEU A  89
VAL A  92
 None
 0.53A 1mz9E-2e2aA:
1.9		 1mz9E-2e2aA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea1 RIBONUCLEASE I

(Escherichia
coli) 		PF00445
(Ribonuclease_T2) 		3 THR A 108
LEU A 112
VAL A 115
 None
 0.55A 1mz9E-2ea1A:
undetectable		 1mz9E-2ea1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus) 		PF00291
(PALP) 		3 THR A  76
LEU A  80
VAL A  83
 None
 0.63A 1mz9E-2eguA:
undetectable		 1mz9E-2eguA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF01230
(HIT) 		3 THR A  54
LEU A  58
VAL A  61
 None
 0.26A 1mz9E-2eo4A:
undetectable		 1mz9E-2eo4A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdm LEGHEMOGLOBIN (OXY)

(Lupinus luteus) 		PF00042
(Globin) 		3 THR A  89
LEU A  93
VAL A  96
 None
HEM  A 154 (-4.6A)
None
 0.53A 1mz9E-2gdmA:
undetectable		 1mz9E-2gdmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnx HYPOTHETICAL PROTEIN

(Mus musculus) 		PF09404
(DUF2003) 		3 THR A 403
LEU A 395
VAL A 382
 None
 0.65A 1mz9E-2gnxA:
undetectable		 1mz9E-2gnxA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 THR A 168
LEU A 172
VAL A 175
 None
 0.68A 1mz9E-2gz3A:
undetectable		 1mz9E-2gz3A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA

(Mycobacterium
tuberculosis) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 THR A  73
LEU A  74
VAL A  80
 None
None
GOL  A 501 ( 4.8A)
 0.68A 1mz9E-2h5xA:
undetectable		 1mz9E-2h5xA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		3 THR A  19
LEU A  23
VAL A  26
 None
 0.56A 1mz9E-2hg4A:
undetectable		 1mz9E-2hg4A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		3 THR A 108
LEU A 112
VAL A 115
 None
 0.60A 1mz9E-2horA:
undetectable		 1mz9E-2horA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		3 THR A 134
LEU A 138
VAL A 141
 None
 0.66A 1mz9E-2i34A:
undetectable		 1mz9E-2i34A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibl FIBRITIN

(Enterobacteria
phage Ox2;
Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 THR A  48
LEU A  52
VAL A  55
 None
 0.31A 1mz9E-2iblA:
3.0		 1mz9E-2iblA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		3 THR A 289
LEU A 293
VAL A 296
 None
 0.68A 1mz9E-2icsA:
undetectable		 1mz9E-2icsA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 THR A 420
LEU A 424
VAL A 427
 None
 0.43A 1mz9E-2ifyA:
undetectable		 1mz9E-2ifyA:
7.00