SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_D_VDYD1001_3

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a81 SYK KINASE

(Homo sapiens) 		PF00017
(SH2) 		3 THR A 256
LEU A 255
LEU A 237
 None
 0.59A 1mz9C-1a81A:
undetectable		 1mz9C-1a81A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 128
LEU A 132
LEU A 139
 None
 0.63A 1mz9C-1aosA:
undetectable		 1mz9C-1aosA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 THR A  54
LEU A  32
LEU A  25
 None
 0.54A 1mz9C-1ayeA:
undetectable		 1mz9C-1ayeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Mycobacterium
leprae) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 THR A  37
LEU A  38
LEU A  10
 None
 0.58A 1mz9C-1bvsA:
undetectable		 1mz9C-1bvsA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 3 THR A  61
LEU A  65
LEU A  72
 None
 0.58A 1mz9C-1bwdA:
undetectable		 1mz9C-1bwdA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		3 THR A 189
LEU A 190
LEU A 151
 None
 0.66A 1mz9C-1c3xA:
undetectable		 1mz9C-1c3xA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3y DNA TOPOISOMERASE VI
A SUBUNIT

(Methanocaldococcus
jannaschii) 		PF04406
(TP6A_N) 		3 THR A  79
LEU A  83
LEU A  90
 None
 0.62A 1mz9C-1d3yA:
undetectable		 1mz9C-1d3yA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		3 THR A 113
LEU A 111
LEU A 120
 None
 0.54A 1mz9C-1dmuA:
undetectable		 1mz9C-1dmuA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		3 THR A 108
LEU A 112
LEU A 119
 None
 0.63A 1mz9C-1eg3A:
undetectable		 1mz9C-1eg3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 THR A  21
LEU A  25
LEU A  32
 None
 0.37A 1mz9C-1ehkA:
undetectable		 1mz9C-1ehkA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 THR A 295
LEU A 299
LEU A 306
 None
 0.61A 1mz9C-1ewkA:
undetectable		 1mz9C-1ewkA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		3 THR A 219
LEU A 150
LEU A  64
 None
 0.44A 1mz9C-1f1xA:
undetectable		 1mz9C-1f1xA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN

(Mus musculus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 THR A 127
LEU A 132
LEU A 139
 None
 0.66A 1mz9C-1f3bA:
undetectable		 1mz9C-1f3bA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 THR A 150
LEU A 151
LEU A 198
 None
 0.62A 1mz9C-1f59A:
undetectable		 1mz9C-1f59A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		3 THR A 205
LEU A 209
LEU A 216
 None
 0.63A 1mz9C-1fbaA:
undetectable		 1mz9C-1fbaA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		3 THR A1205
LEU A1209
LEU A1216
 None
 0.63A 1mz9C-1fdjA:
undetectable		 1mz9C-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1few SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		3 THR A  30
LEU A  34
LEU A  41
 None
 0.56A 1mz9C-1fewA:
undetectable		 1mz9C-1fewA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxi FERREDOXIN I

(Aphanothece
sacrum) 		PF00111
(Fer2) 		3 THR A  76
LEU A  75
LEU A  64
 None
FES  A  97 (-4.1A)
None
 0.58A 1mz9C-1fxiA:
undetectable		 1mz9C-1fxiA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxk PROTEIN (PREFOLDIN)

(Methanothermobacter
thermautotrophicus) 		PF02996
(Prefoldin) 		3 THR C  34
LEU C  38
LEU C  45
 None
 0.57A 1mz9C-1fxkC:
2.1		 1mz9C-1fxkC:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g73 SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		3 THR A  30
LEU A  34
LEU A  41
 None
 0.53A 1mz9C-1g73A:
2.2		 1mz9C-1g73A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1

(Mus musculus) 		PF12352
(V-SNARE_C) 		3 THR C 177
LEU C 181
LEU C 188
 None
 0.54A 1mz9C-1gl2C:
4.4		 1mz9C-1gl2C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1

(Mus musculus) 		PF12352
(V-SNARE_C) 		3 THR C 184
LEU C 188
LEU C 195
 None
 0.58A 1mz9C-1gl2C:
4.4		 1mz9C-1gl2C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gs9 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 THR A  67
LEU A  71
LEU A  78
 None
 0.66A 1mz9C-1gs9A:
undetectable		 1mz9C-1gs9A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 THR A 372
LEU A 373
LEU A 380
 None
 0.64A 1mz9C-1gzkA:
undetectable		 1mz9C-1gzkA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		3 THR A  21
LEU A  25
LEU A  32
 None
 0.65A 1mz9C-1h65A:
undetectable		 1mz9C-1h65A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		3 THR A 136
LEU A 137
LEU A 181
 None
 0.63A 1mz9C-1hm6A:
undetectable		 1mz9C-1hm6A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		3 THR A 181
LEU A 185
LEU A 192
 None
 0.65A 1mz9C-1hx8A:
undetectable		 1mz9C-1hx8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI

(Lechevalieria
aerocolonigenes) 		PF09126
(NaeI) 		3 THR A  32
LEU A  36
LEU A  43
 None
 0.61A 1mz9C-1iawA:
undetectable		 1mz9C-1iawA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ic2 TROPOMYOSIN ALPHA
CHAIN, SKELETAL
MUSCLE

(Gallus gallus) 		PF12718
(Tropomyosin_1) 		3 THR A  53
LEU A  57
LEU A  64
 None
 0.49A 1mz9C-1ic2A:
3.7		 1mz9C-1ic2A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		3 THR C 370
LEU C 369
LEU C 514
 None
 0.66A 1mz9C-1j3jC:
undetectable		 1mz9C-1j3jC:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jun C-JUN HOMODIMER

(Homo sapiens) 		PF00170
(bZIP_1) 		3 THR A 297
LEU A 301
LEU A 308
 None
 0.63A 1mz9C-1junA:
4.7		 1mz9C-1junA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 THR A  95
LEU A  99
LEU A 106
 DND  A 301 (-3.9A)
None
None
 0.52A 1mz9C-1kqoA:
undetectable		 1mz9C-1kqoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 THR A 640
LEU A 641
LEU A 626
 None
 0.66A 1mz9C-1l5jA:
undetectable		 1mz9C-1l5jA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 THR A  67
LEU A  71
LEU A  78
 None
 0.62A 1mz9C-1lpeA:
undetectable		 1mz9C-1lpeA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvf SYNTAXIN 6

(Rattus
norvegicus) 		PF09177
(Syntaxin-6_N) 		3 THR A  20
LEU A  24
LEU A  31
 None
 0.61A 1mz9C-1lvfA:
2.4		 1mz9C-1lvfA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 THR A 395
LEU A 399
LEU A 406
 None
 0.56A 1mz9C-1lwdA:
undetectable		 1mz9C-1lwdA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 THR C  36
LEU C  40
LEU C  47
 None
 0.39A 1mz9C-1m1jC:
3.8		 1mz9C-1m1jC:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m76 3-HYDROXYACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 THR A 181
LEU A 185
LEU A 192
 None
 0.65A 1mz9C-1m76A:
undetectable		 1mz9C-1m76A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		3 THR A 246
LEU A 116
LEU A 161
 None
 0.64A 1mz9C-1mg1A:
3.5		 1mz9C-1mg1A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		3 THR A 100
LEU A 104
LEU A 111
 None
 0.59A 1mz9C-1mg7A:
undetectable		 1mz9C-1mg7A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1q DPS PROTEIN

(Brevibacillus
brevis) 		PF00210
(Ferritin) 		3 THR A  59
LEU A  60
LEU A  12
 None
 0.61A 1mz9C-1n1qA:
undetectable		 1mz9C-1n1qA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 THR A 377
LEU A 381
LEU A 388
 None
 0.54A 1mz9C-1n8pA:
undetectable		 1mz9C-1n8pA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT

(Methanothermobacter
thermautotrophicus) 		PF01873
(eIF-5_eIF-2B) 		3 THR A  68
LEU A  66
LEU A  59
 None
 0.49A 1mz9C-1neeA:
undetectable		 1mz9C-1neeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 3 THR A  41
LEU A  45
LEU A  54
 None
 0.55A 1mz9C-1nluA:
undetectable		 1mz9C-1nluA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 THR A 190
LEU A 189
LEU A 102
 None
 0.64A 1mz9C-1nr9A:
undetectable		 1mz9C-1nr9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 THR A  93
LEU A  97
LEU A 104
 NXX  A 401 (-4.3A)
None
None
 0.57A 1mz9C-1nuqA:
undetectable		 1mz9C-1nuqA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN

(Drosophila
melanogaster) 		PF12796
(Ank_2) 		3 THR A  46
LEU A  43
LEU A  36
 None
 0.53A 1mz9C-1ot8A:
undetectable		 1mz9C-1ot8A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		3 THR A   6
LEU A  10
LEU A  17
 None
 0.51A 1mz9C-1otkA:
undetectable		 1mz9C-1otkA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbw PHOSPHATIDYLINOSITOL
3-KINASE

(Homo sapiens) 		PF00620
(RhoGAP) 		3 THR A 239
LEU A 243
LEU A 250
 None
 0.64A 1mz9C-1pbwA:
undetectable		 1mz9C-1pbwA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 309
LEU A 312
LEU A 129
 None
 0.66A 1mz9C-1pjbA:
undetectable		 1mz9C-1pjbA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 THR A 407
LEU A 428
LEU A 345
 NAG  A 808 (-2.2A)
None
None
 0.55A 1mz9C-1q5aA:
undetectable		 1mz9C-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 THR A 335
LEU A 339
LEU A 346
 None
 0.66A 1mz9C-1q5nA:
undetectable		 1mz9C-1q5nA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7s BIT1

(Homo sapiens) 		PF01981
(PTH2) 		3 THR A 125
LEU A 129
LEU A 136
 None
 0.66A 1mz9C-1q7sA:
undetectable		 1mz9C-1q7sA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 THR A 126
LEU A 127
LEU A 167
 None
 0.62A 1mz9C-1qapA:
undetectable		 1mz9C-1qapA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 THR A 734
LEU A 735
LEU A 692
 None
 0.60A 1mz9C-1qf7A:
undetectable		 1mz9C-1qf7A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 THR A 150
LEU A 151
LEU A 198
 None
 0.55A 1mz9C-1qgrA:
undetectable		 1mz9C-1qgrA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcd L FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		3 THR A 140
LEU A 144
LEU A 151
 None
 0.40A 1mz9C-1rcdA:
undetectable		 1mz9C-1rcdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		3 THR A 275
LEU A 315
LEU A  47
 None
 0.66A 1mz9C-1rh9A:
undetectable		 1mz9C-1rh9A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		3 THR A 199
LEU A 203
LEU A 210
 None
 0.41A 1mz9C-1rtrA:
undetectable		 1mz9C-1rtrA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svi GTP-BINDING PROTEIN
YSXC

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		3 THR A 162
LEU A 163
LEU A 130
 None
 0.46A 1mz9C-1sviA:
undetectable		 1mz9C-1sviA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 THR A 383
LEU A 387
LEU A 394
 None
 0.55A 1mz9C-1t1uA:
undetectable		 1mz9C-1t1uA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3j MITOFUSIN 1

(Mus musculus) 		PF04799
(Fzo_mitofusin) 		3 THR A 687
LEU A 691
LEU A 698
 None
 0.65A 1mz9C-1t3jA:
4.2		 1mz9C-1t3jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		3 THR A 211
LEU A 215
LEU A 222
 None
 0.59A 1mz9C-1t98A:
undetectable		 1mz9C-1t98A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 124
LEU A 128
LEU A 135
 None
 0.58A 1mz9C-1tj7A:
undetectable		 1mz9C-1tj7A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		3 THR D 148
LEU D 152
LEU D 159
 None
 0.63A 1mz9C-1unlD:
undetectable		 1mz9C-1unlD:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		3 THR A 219
LEU A 223
LEU A 230
 CIT  A1294 ( 3.6A)
CIT  A1294 (-4.5A)
None
 0.21A 1mz9C-1uzrA:
undetectable		 1mz9C-1uzrA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		3 THR A 259
LEU A 258
LEU A 239
 None
 0.59A 1mz9C-1vs1A:
undetectable		 1mz9C-1vs1A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		3 THR A  91
LEU A  95
LEU A 102
 None
 0.39A 1mz9C-1w2wA:
undetectable		 1mz9C-1w2wA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00290
(Trp_syntA) 		3 THR A 121
LEU A  94
LEU A  22
 None
 0.64A 1mz9C-1wxjA:
undetectable		 1mz9C-1wxjA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3s RAS-RELATED PROTEIN
RAB-18

(Homo sapiens) 		PF00071
(Ras) 		3 THR A  95
LEU A  99
LEU A 106
 None
 0.64A 1mz9C-1x3sA:
undetectable		 1mz9C-1x3sA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		3 THR A 142
LEU A 295
LEU A 121
 None
 0.53A 1mz9C-1xcoA:
undetectable		 1mz9C-1xcoA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		3 THR A 190
LEU A 191
LEU A 162
 None
 0.59A 1mz9C-1xdzA:
undetectable		 1mz9C-1xdzA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 THR A 239
LEU A 218
LEU A 173
 None
 0.58A 1mz9C-1xecA:
undetectable		 1mz9C-1xecA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhe AEROBIC RESPIRATION
CONTROL PROTEIN ARCA

(Escherichia
coli) 		PF00072
(Response_reg) 		3 THR A  18
LEU A  19
LEU A  50
 None
 0.57A 1mz9C-1xheA:
undetectable		 1mz9C-1xheA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xly SHE2P

(Saccharomyces
cerevisiae) 		PF11435
(She2p) 		3 THR A 109
LEU A 113
LEU A 121
 None
 0.48A 1mz9C-1xlyA:
undetectable		 1mz9C-1xlyA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		3 THR A 236
LEU A 240
LEU A 247
 None
 0.63A 1mz9C-1xnfA:
undetectable		 1mz9C-1xnfA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		3 THR A 167
LEU A 171
LEU A 178
 None
 0.64A 1mz9C-1xq1A:
undetectable		 1mz9C-1xq1A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgg PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YWLE

(Bacillus
subtilis) 		PF01451
(LMWPc) 		3 THR A 130
LEU A 134
LEU A 141
 None
 0.65A 1mz9C-1zggA:
undetectable		 1mz9C-1zggA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		3 THR A 264
LEU A 268
LEU A 275
 None
 0.49A 1mz9C-1zlpA:
undetectable		 1mz9C-1zlpA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		3 THR A 356
LEU A 357
LEU A 197
 None
 0.61A 1mz9C-1zovA:
undetectable		 1mz9C-1zovA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		3 THR A 146
LEU A 150
LEU A 157
 None
 0.66A 1mz9C-2a9sA:
undetectable		 1mz9C-2a9sA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 THR A  67
LEU A  66
LEU A 220
 None
 0.54A 1mz9C-2aazA:
undetectable		 1mz9C-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		3 THR A 152
LEU A 156
LEU A 163
 None
 0.39A 1mz9C-2amlA:
undetectable		 1mz9C-2amlA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 THR A 136
LEU A 140
LEU A 147
 None
 0.44A 1mz9C-2c3nA:
undetectable		 1mz9C-2c3nA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 THR A 272
LEU A 377
LEU A  82
 None
 0.51A 1mz9C-2canA:
undetectable		 1mz9C-2canA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		3 THR A  10
LEU A  14
LEU A  21
 None
 0.47A 1mz9C-2cwoA:
undetectable		 1mz9C-2cwoA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		3 THR A  79
LEU A  83
LEU A  90
 None
 0.60A 1mz9C-2d2xA:
undetectable		 1mz9C-2d2xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		3 THR A  39
LEU A  43
LEU A  50
 None
 0.55A 1mz9C-2d57A:
undetectable		 1mz9C-2d57A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec2 136AA LONG
HYPOTHETICAL
TRANSPOSASE

(Sulfurisphaera
tokodaii) 		PF01797
(Y1_Tnp) 		3 THR A  36
LEU A  40
LEU A  47
 None
 0.65A 1mz9C-2ec2A:
undetectable		 1mz9C-2ec2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		3 THR A 274
LEU A 278
LEU A 285
 None
 0.54A 1mz9C-2ef4A:
undetectable		 1mz9C-2ef4A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		3 THR A 191
LEU A 195
LEU A 202
 None
 0.61A 1mz9C-2eijA:
undetectable		 1mz9C-2eijA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekf ANCIENT UBIQUITOUS
PROTEIN 1

(Homo sapiens) 		PF02845
(CUE) 		3 THR A  15
LEU A  16
LEU A  44
 None
 0.55A 1mz9C-2ekfA:
undetectable		 1mz9C-2ekfA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 THR A 299
LEU A 303
LEU A 310
 None
 0.63A 1mz9C-2eklA:
undetectable		 1mz9C-2eklA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5g TRANSPOSASE,
PUTATIVE

(Sulfolobus
solfataricus) 		PF01797
(Y1_Tnp) 		3 THR A  36
LEU A  40
LEU A  47
 None
 0.65A 1mz9C-2f5gA:
undetectable		 1mz9C-2f5gA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 THR X 300
LEU X 299
LEU X 256
 None
 0.62A 1mz9C-2f6hX:
undetectable		 1mz9C-2f6hX:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flh CYTOKININ-SPECIFIC
BINDING PROTEIN

(Vigna radiata) 		PF00407
(Bet_v_1) 		3 THR A 139
LEU A 143
LEU A 150
 ZEA  A 701 (-3.1A)
None
None
 0.64A 1mz9C-2flhA:
undetectable		 1mz9C-2flhA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		3 THR A 124
LEU A 125
LEU A 171
 None
 0.57A 1mz9C-2hnkA:
undetectable		 1mz9C-2hnkA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18

(Saccharomyces
cerevisiae) 		PF09637
(Med18) 		3 THR B 271
LEU B 275
LEU B 282
 None
 0.65A 1mz9C-2hzsB:
undetectable		 1mz9C-2hzsB:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE

(Bacteroides
thetaiotaomicron) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 THR A 100
LEU A 104
LEU A 111
 None
 0.43A 1mz9C-2j4gA:
undetectable		 1mz9C-2j4gA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 THR D 118
LEU D 122
LEU D 129
 None
 0.64A 1mz9C-2j7pD:
undetectable		 1mz9C-2j7pD:
14.74