SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_D_VDYD1001_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		3 LEU A 133
VAL A 136
LEU A 140
 None
 0.49A 1mz9B-1a0fA:
undetectable		 1mz9B-1a0fA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avo 11S REGULATOR

(Homo sapiens) 		PF02252
(PA28_beta) 		3 LEU B 128
VAL B 131
LEU B 135
 None
 0.36A 1mz9B-1avoB:
1.1		 1mz9B-1avoB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 LEU A 363
VAL A 366
LEU A 370
 None
 0.38A 1mz9B-1b3bA:
0.0		 1mz9B-1b3bA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A  49
VAL A  52
LEU A  56
 None
 0.53A 1mz9B-1bdmA:
undetectable		 1mz9B-1bdmA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c94 RETRO-GCN4 LEUCINE
ZIPPER

(-) 		no annotation 3 LEU A  11
VAL A  14
LEU A  18
 None
 0.32A 1mz9B-1c94A:
3.8		 1mz9B-1c94A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c94 RETRO-GCN4 LEUCINE
ZIPPER

(-) 		no annotation 3 LEU A  25
VAL A  28
LEU A  32
 None
 0.35A 1mz9B-1c94A:
3.8		 1mz9B-1c94A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		3 LEU A 142
VAL A 145
LEU A 149
 None
 0.46A 1mz9B-1cfzA:
undetectable		 1mz9B-1cfzA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (ALPHA
SUBUNIT)

(Microchaete
diplosiphon) 		PF00502
(Phycobilisome) 		3 LEU A  92
VAL A  95
LEU A  99
 None
 0.50A 1mz9B-1cpcA:
1.3		 1mz9B-1cpcA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 LEU A 163
VAL A 166
LEU A 170
 None
 0.51A 1mz9B-1cptA:
0.0		 1mz9B-1cptA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d66 PROTEIN (GAL4)

(Saccharomyces
cerevisiae) 		PF00172
(Zn_clus)
PF03902
(Gal4_dimer) 		3 LEU A  54
VAL A  57
LEU A  61
 None
 0.44A 1mz9B-1d66A:
undetectable		 1mz9B-1d66A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE

(Escherichia
coli) 		PF01025
(GrpE) 		3 LEU A  95
VAL A  98
LEU A 102
 None
 0.47A 1mz9B-1dkgA:
4.0		 1mz9B-1dkgA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 LEU A 227
VAL A 230
LEU A 234
 None
 0.53A 1mz9B-1dmwA:
undetectable		 1mz9B-1dmwA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae) 		PF02840
(Prp18) 		3 LEU A 163
VAL A 166
LEU A 170
 None
 0.33A 1mz9B-1dvkA:
undetectable		 1mz9B-1dvkA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		3 LEU A 120
VAL A 123
LEU A 127
 None
 0.47A 1mz9B-1efvA:
undetectable		 1mz9B-1efvA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		3 LEU A  78
VAL A  81
LEU A  85
 None
 0.45A 1mz9B-1evsA:
undetectable		 1mz9B-1evsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f45 INTERLEUKIN-12 ALPHA
CHAIN

(Homo sapiens) 		PF03039
(IL12) 		3 LEU B  23
VAL B  26
LEU B  30
 None
 0.52A 1mz9B-1f45B:
undetectable		 1mz9B-1f45B:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f99 R-PHYCOCYANIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		3 LEU A  92
VAL A  95
LEU A  99
 None
 0.47A 1mz9B-1f99A:
undetectable		 1mz9B-1f99A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		3 LEU A 212
VAL A 215
LEU A 219
 None
 0.49A 1mz9B-1fc9A:
undetectable		 1mz9B-1fc9A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 LEU A1041
VAL A1044
LEU A1048
 None
 0.51A 1mz9B-1foeA:
undetectable		 1mz9B-1foeA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		3 LEU A 427
VAL A 430
LEU A 434
 C  B 534 ( 3.6A)
None
None
 0.38A 1mz9B-1g59A:
undetectable		 1mz9B-1g59A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		3 LEU A 391
VAL A 394
LEU A 398
 None
 0.53A 1mz9B-1h3gA:
undetectable		 1mz9B-1h3gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)

(Gallus gallus) 		PF00042
(Globin) 		3 LEU A 129
VAL A 132
LEU A 136
 None
 0.50A 1mz9B-1hbrA:
undetectable		 1mz9B-1hbrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hci ALPHA-ACTININ 2

(Homo sapiens) 		PF00435
(Spectrin) 		3 LEU A 434
VAL A 437
LEU A 441
 None
 0.52A 1mz9B-1hciA:
undetectable		 1mz9B-1hciA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		3 LEU P 128
VAL P 131
LEU P 135
 None
 0.33A 1mz9B-1hynP:
undetectable		 1mz9B-1hynP:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 LEU A 242
VAL A 245
LEU A 249
 None
 0.47A 1mz9B-1i0aA:
undetectable		 1mz9B-1i0aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 LEU A 186
VAL A 189
LEU A 193
 None
 0.30A 1mz9B-1i9gA:
undetectable		 1mz9B-1i9gA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyv DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Azotobacter
vinelandii) 		PF00364
(Biotin_lipoyl) 		3 LEU A  35
VAL A  44
LEU A  32
 None
 0.52A 1mz9B-1iyvA:
undetectable		 1mz9B-1iyvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermotoga
maritima) 		PF02091
(tRNA-synt_2e) 		3 LEU A   3
VAL A   6
LEU A  10
 None
 0.53A 1mz9B-1j5wA:
undetectable		 1mz9B-1j5wA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 LEU A 357
VAL A 360
LEU A 364
 None
 0.49A 1mz9B-1lgfA:
undetectable		 1mz9B-1lgfA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lia R-PHYCOERYTHRIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		3 LEU B  92
VAL B  95
LEU B  99
 None
 0.45A 1mz9B-1liaB:
undetectable		 1mz9B-1liaB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		3 LEU A 321
VAL A 324
LEU A 328
 None
 0.48A 1mz9B-1lnzA:
undetectable		 1mz9B-1lnzA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LEU B 173
VAL B 176
LEU B 180
 None
 0.40A 1mz9B-1m1jB:
3.5		 1mz9B-1m1jB:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LEU A 212
VAL A 215
LEU A 219
 None
 0.53A 1mz9B-1mc8A:
undetectable		 1mz9B-1mc8A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf1 PROTEIN
(NEUROFIBROMIN)

(Homo sapiens) 		PF00616
(RasGAP) 		3 LEU A1361
VAL A1364
LEU A1368
 None
 0.47A 1mz9B-1nf1A:
undetectable		 1mz9B-1nf1A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nub BASEMENT MEMBRANE
PROTEIN BM-40

(Homo sapiens) 		PF00050
(Kazal_1)
PF09289
(FOLN)
PF10591
(SPARC_Ca_bdg) 		3 LEU A 154
VAL A 157
LEU A 161
 None
 0.53A 1mz9B-1nubA:
undetectable		 1mz9B-1nubA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		3 LEU A  94
VAL A  97
LEU A 101
 None
 0.51A 1mz9B-1nznA:
undetectable		 1mz9B-1nznA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 LEU A 434
VAL A 437
LEU A 441
 None
 0.44A 1mz9B-1o5tA:
undetectable		 1mz9B-1o5tA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 LEU A 202
VAL A 205
LEU A 209
 None
 0.50A 1mz9B-1osnA:
undetectable		 1mz9B-1osnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 LEU A 190
VAL A 193
LEU A 197
 None
 0.32A 1mz9B-1p49A:
undetectable		 1mz9B-1p49A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 LEU A 239
VAL A 242
LEU A 246
 None
 0.47A 1mz9B-1p50A:
undetectable		 1mz9B-1p50A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS

(Burkholderia
pseudomallei) 		PF01007
(IRK) 		3 LEU A  70
VAL A  73
LEU A  77
 None
 0.22A 1mz9B-1p7bA:
undetectable		 1mz9B-1p7bA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		3 LEU A 227
VAL A 230
LEU A 234
 None
 0.46A 1mz9B-1phzA:
undetectable		 1mz9B-1phzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 LEU B 307
VAL B 310
LEU B 314
 None
 0.43A 1mz9B-1pjmB:
undetectable		 1mz9B-1pjmB:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		3 LEU A 181
VAL A 184
LEU A 188
 None
 0.41A 1mz9B-1ps6A:
undetectable		 1mz9B-1ps6A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 513
VAL A 511
LEU A 475
 None
 0.00A 1mz9B-1q5aA:
undetectable		 1mz9B-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 LEU A 151
VAL A 154
LEU A 158
 None
 0.50A 1mz9B-1qhfA:
undetectable		 1mz9B-1qhfA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r62 NITROGEN REGULATION
PROTEIN NR(II)

(Escherichia
coli) 		PF02518
(HATPase_c) 		3 LEU A 243
VAL A 246
LEU A 250
 None
 0.51A 1mz9B-1r62A:
undetectable		 1mz9B-1r62A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 LEU A 434
VAL A 437
LEU A 441
 None
 0.45A 1mz9B-1r6uA:
undetectable		 1mz9B-1r6uA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru1 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE

(Escherichia
coli) 		PF01288
(HPPK) 		3 LEU A  15
VAL A  18
LEU A  22
 None
 0.53A 1mz9B-1ru1A:
undetectable		 1mz9B-1ru1A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0h HEMOGLOBIN ALPHA
CHAIN

(Equus asinus) 		PF00042
(Globin) 		3 LEU A 129
VAL A 132
LEU A 136
 None
 0.51A 1mz9B-1s0hA:
undetectable		 1mz9B-1s0hA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 LEU A 283
VAL A 286
LEU A 290
 None
 0.51A 1mz9B-1sqgA:
undetectable		 1mz9B-1sqgA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		3 LEU A 136
VAL A 139
LEU A 143
 None
 0.50A 1mz9B-1t0iA:
undetectable		 1mz9B-1t0iA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		3 LEU A  88
VAL A  91
LEU A  95
 None
 0.51A 1mz9B-1td6A:
undetectable		 1mz9B-1td6A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		3 LEU A 105
VAL A 108
LEU A 112
 None
 0.49A 1mz9B-1ttwA:
undetectable		 1mz9B-1ttwA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 LEU A  34
VAL A  37
LEU A  41
 None
 0.42A 1mz9B-1u1hA:
undetectable		 1mz9B-1u1hA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		3 LEU A1695
VAL A1698
LEU A1702
 None
 0.47A 1mz9B-1u4qA:
undetectable		 1mz9B-1u4qA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub9 HYPOTHETICAL PROTEIN
PH1061

(Pyrococcus
horikoshii) 		PF13601
(HTH_34) 		3 LEU A  91
VAL A  94
LEU A  98
 None
 0.51A 1mz9B-1ub9A:
undetectable		 1mz9B-1ub9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usd VASODILATOR-STIMULAT
ED PHOSPHOPROTEIN

(Homo sapiens) 		PF08776
(VASP_tetra) 		3 LEU A 344
VAL A 347
LEU A 351
 None
 0.51A 1mz9B-1usdA:
4.7		 1mz9B-1usdA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 LEU A 402
VAL A 405
LEU A 409
 None
 0.52A 1mz9B-1v4gA:
undetectable		 1mz9B-1v4gA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 LEU A 413
VAL A 416
LEU A 420
 None
 0.50A 1mz9B-1v4gA:
undetectable		 1mz9B-1v4gA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7n THROMBOPOIETIN

(Homo sapiens) 		PF00758
(EPO_TPO) 		3 LEU V  64
VAL V  67
LEU V  71
 None
 0.49A 1mz9B-1v7nV:
undetectable		 1mz9B-1v7nV:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 LEU A 154
VAL A 157
LEU A 161
 None
 0.53A 1mz9B-1vc2A:
undetectable		 1mz9B-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 LEU A2197
VAL A2200
LEU A2204
 None
 0.51A 1mz9B-1wchA:
undetectable		 1mz9B-1wchA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdi HYPOTHETICAL PROTEIN
TT0907

(Thermus
thermophilus) 		PF02547
(Queuosine_synth) 		3 LEU A 309
VAL A 312
LEU A 316
 None
 0.42A 1mz9B-1wdiA:
undetectable		 1mz9B-1wdiA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		3 LEU A 383
VAL A 386
LEU A 390
 None
 0.52A 1mz9B-1xa6A:
undetectable		 1mz9B-1xa6A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		3 LEU A 210
VAL A 213
LEU A 217
 None
 0.51A 1mz9B-1xfbA:
undetectable		 1mz9B-1xfbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 B-PHYCOERYTHRIN BETA
CHAIN

(Rhodomonas sp.
CS24) 		PF00502
(Phycobilisome) 		3 LEU C  90
VAL C  93
LEU C  97
 None
 0.44A 1mz9B-1xg0C:
undetectable		 1mz9B-1xg0C:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		3 LEU A 249
VAL A 252
LEU A 256
 None
 0.35A 1mz9B-1xr5A:
undetectable		 1mz9B-1xr5A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.) 		PF01590
(GAF) 		3 LEU A  65
VAL A  68
LEU A  72
 None
 0.52A 1mz9B-1ykdA:
undetectable		 1mz9B-1ykdA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqf HYPOTHETICAL PROTEIN
LMAJ011689

(Leishmania
major) 		PF02330
(MAM33) 		3 LEU A 151
VAL A 154
LEU A 158
 None
 0.39A 1mz9B-1yqfA:
undetectable		 1mz9B-1yqfA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		3 LEU A1180
VAL A1183
LEU A1187
 None
 0.43A 1mz9B-1yxoA:
undetectable		 1mz9B-1yxoA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LEU A 671
VAL A 674
LEU A 678
 None
 0.50A 1mz9B-1zcjA:
undetectable		 1mz9B-1zcjA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk8 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF13305
(WHG) 		3 LEU A  52
VAL A  55
LEU A  59
 None
 0.41A 1mz9B-1zk8A:
undetectable		 1mz9B-1zk8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a26 CALCYCLIN-BINDING
PROTEIN

(Homo sapiens) 		PF09032
(Siah-Interact_N) 		3 LEU A  10
VAL A  13
LEU A  17
 None
 0.41A 1mz9B-2a26A:
1.9		 1mz9B-2a26A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		3 LEU A 158
VAL A 161
LEU A 165
 None
 0.52A 1mz9B-2a9jA:
undetectable		 1mz9B-2a9jA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		3 LEU A 250
VAL A 253
LEU A 257
 None
 0.36A 1mz9B-2aa4A:
undetectable		 1mz9B-2aa4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 LEU A  73
VAL A  76
LEU A  80
 None
 0.37A 1mz9B-2aazA:
undetectable		 1mz9B-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 LEU A 302
VAL A 269
LEU A 254
 None
 0.52A 1mz9B-2am2A:
undetectable		 1mz9B-2am2A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 LEU B 498
VAL B 501
LEU B 505
 None
 0.40A 1mz9B-2amcB:
undetectable		 1mz9B-2amcB:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b22 GENERAL CONTROL
PROTEIN GCN4

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A   5
VAL A   8
LEU A  12
 None
 0.54A 1mz9B-2b22A:
undetectable		 1mz9B-2b22A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b22 GENERAL CONTROL
PROTEIN GCN4

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A  12
VAL A  15
LEU A  19
 None
 0.37A 1mz9B-2b22A:
undetectable		 1mz9B-2b22A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		3 LEU I 292
VAL I 295
LEU I 299
 None
 0.32A 1mz9B-2b4xI:
undetectable		 1mz9B-2b4xI:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		3 LEU A 453
VAL A 456
LEU A 460
 None
 0.48A 1mz9B-2b9bA:
undetectable		 1mz9B-2b9bA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9c STRIATED-MUSCLE
ALPHA TROPOMYOSIN

(Rattus
norvegicus) 		PF00261
(Tropomyosin) 		3 LEU A 197
VAL A 200
LEU A 204
 None
 0.36A 1mz9B-2b9cA:
undetectable		 1mz9B-2b9cA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		3 LEU A  92
VAL A  95
LEU A  99
 None
 0.53A 1mz9B-2bv8A:
undetectable		 1mz9B-2bv8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Rattus
norvegicus) 		PF03114
(BAR) 		3 LEU A 233
VAL A 236
LEU A 240
 None
 0.53A 1mz9B-2c08A:
undetectable		 1mz9B-2c08A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		3 LEU A 159
VAL A 394
LEU A 392
 None
 0.48A 1mz9B-2cunA:
undetectable		 1mz9B-2cunA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 LEU A 569
VAL A 572
LEU A 576
 None
 0.41A 1mz9B-2dhrA:
undetectable		 1mz9B-2dhrA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		3 LEU A 573
VAL A 576
LEU A 580
 None
 0.43A 1mz9B-2di4A:
undetectable		 1mz9B-2di4A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		3 LEU A 153
VAL A 156
LEU A 160
 None
 0.24A 1mz9B-2djzA:
undetectable		 1mz9B-2djzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A  91
VAL A  94
LEU A  98
 None
 0.45A 1mz9B-2dq3A:
undetectable		 1mz9B-2dq3A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsq INSULIN-LIKE GROWTH
FACTOR-BINDING
PROTEIN 1

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		3 LEU G 155
VAL G 158
LEU G 162
 None
 0.52A 1mz9B-2dsqG:
undetectable		 1mz9B-2dsqG:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f06 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 3 LEU A  83
VAL A  86
LEU A  90
 HIS  A 152 (-3.7A)
None
None
 0.53A 1mz9B-2f06A:
undetectable		 1mz9B-2f06A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8n HISTONE H2A TYPE 1

(Mus musculus) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 LEU K  51
VAL K  54
LEU K  58
 None
 0.48A 1mz9B-2f8nK:
undetectable		 1mz9B-2f8nK:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		3 LEU A 236
VAL A 239
LEU A 243
 None
 0.50A 1mz9B-2f9tA:
undetectable		 1mz9B-2f9tA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		3 LEU A 174
VAL A 177
LEU A 181
 None
 0.47A 1mz9B-2g18A:
undetectable		 1mz9B-2g18A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		3 LEU A 415
VAL A 420
LEU A 423
 None
 0.53A 1mz9B-2gduA:
undetectable		 1mz9B-2gduA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		3 LEU A   2
VAL A   5
LEU A   9
 None
 0.37A 1mz9B-2gtiA:
undetectable		 1mz9B-2gtiA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hd7 TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		3 LEU A 190
VAL A 283
LEU A 280
 None
 0.42A 1mz9B-2hd7A:
undetectable		 1mz9B-2hd7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh7 HYPOTHETICAL PROTEIN
CSOR

(Mycobacterium
tuberculosis) 		PF02583
(Trns_repr_metal) 		3 LEU A  16
VAL A  19
LEU A  23
 None
 0.51A 1mz9B-2hh7A:
undetectable		 1mz9B-2hh7A:
17.95