SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_D_VDYD1001

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0f GLUTATHIONE
S-TRANSFERASE

(Escherichia
coli) 		PF00043
(GST_C)
PF13409
(GST_N_2) 		3 LEU A 133
VAL A 136
LEU A 140
 None
 0.49A 1mz9B-1a0fA:
undetectable		 1mz9B-1a0fA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avo 11S REGULATOR

(Homo sapiens) 		PF02252
(PA28_beta) 		3 LEU B 128
VAL B 131
LEU B 135
 None
 0.36A 1mz9B-1avoB:
1.1		 1mz9B-1avoB:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b3b PROTEIN (GLUTAMATE
DEHYDROGENASE)

(Thermotoga
maritima) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		3 LEU A 363
VAL A 366
LEU A 370
 None
 0.38A 1mz9B-1b3bA:
0.0		 1mz9B-1b3bA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdm MALATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		3 LEU A  49
VAL A  52
LEU A  56
 None
 0.53A 1mz9B-1bdmA:
undetectable		 1mz9B-1bdmA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c94 RETRO-GCN4 LEUCINE
ZIPPER

(-) 		no annotation 3 LEU A  11
VAL A  14
LEU A  18
 None
 0.32A 1mz9B-1c94A:
3.8		 1mz9B-1c94A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c94 RETRO-GCN4 LEUCINE
ZIPPER

(-) 		no annotation 3 LEU A  25
VAL A  28
LEU A  32
 None
 0.35A 1mz9B-1c94A:
3.8		 1mz9B-1c94A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cfz HYDROGENASE 2
MATURATION PROTEASE

(Escherichia
coli) 		PF01750
(HycI) 		3 LEU A 142
VAL A 145
LEU A 149
 None
 0.46A 1mz9B-1cfzA:
undetectable		 1mz9B-1cfzA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpc C-PHYCOCYANIN (ALPHA
SUBUNIT)

(Microchaete
diplosiphon) 		PF00502
(Phycobilisome) 		3 LEU A  92
VAL A  95
LEU A  99
 None
 0.50A 1mz9B-1cpcA:
1.3		 1mz9B-1cpcA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 LEU A 163
VAL A 166
LEU A 170
 None
 0.51A 1mz9B-1cptA:
0.0		 1mz9B-1cptA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d66 PROTEIN (GAL4)

(Saccharomyces
cerevisiae) 		PF00172
(Zn_clus)
PF03902
(Gal4_dimer) 		3 LEU A  54
VAL A  57
LEU A  61
 None
 0.44A 1mz9B-1d66A:
undetectable		 1mz9B-1d66A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg NUCLEOTIDE EXCHANGE
FACTOR GRPE

(Escherichia
coli) 		PF01025
(GrpE) 		3 LEU A  95
VAL A  98
LEU A 102
 None
 0.47A 1mz9B-1dkgA:
4.0		 1mz9B-1dkgA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmw PHENYLALANINE
HYDROXYLASE

(Homo sapiens) 		PF00351
(Biopterin_H) 		3 LEU A 227
VAL A 230
LEU A 234
 None
 0.53A 1mz9B-1dmwA:
undetectable		 1mz9B-1dmwA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dvk PRP18

(Saccharomyces
cerevisiae) 		PF02840
(Prp18) 		3 LEU A 163
VAL A 166
LEU A 170
 None
 0.33A 1mz9B-1dvkA:
undetectable		 1mz9B-1dvkA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		3 LEU A 120
VAL A 123
LEU A 127
 None
 0.47A 1mz9B-1efvA:
undetectable		 1mz9B-1efvA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evs ONCOSTATIN M

(Homo sapiens) 		PF01291
(LIF_OSM) 		3 LEU A  78
VAL A  81
LEU A  85
 None
 0.45A 1mz9B-1evsA:
undetectable		 1mz9B-1evsA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f45 INTERLEUKIN-12 ALPHA
CHAIN

(Homo sapiens) 		PF03039
(IL12) 		3 LEU B  23
VAL B  26
LEU B  30
 None
 0.52A 1mz9B-1f45B:
undetectable		 1mz9B-1f45B:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f99 R-PHYCOCYANIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		3 LEU A  92
VAL A  95
LEU A  99
 None
 0.47A 1mz9B-1f99A:
undetectable		 1mz9B-1f99A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fc9 PHOTOSYSTEM II D1
PROTEASE

(Tetradesmus
obliquus) 		PF03572
(Peptidase_S41)
PF13180
(PDZ_2) 		3 LEU A 212
VAL A 215
LEU A 219
 None
 0.49A 1mz9B-1fc9A:
undetectable		 1mz9B-1fc9A:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1foe T-LYMPHOMA INVASION
AND METASTASIS
INDUCING PROTEIN 1

(Mus musculus) 		PF00169
(PH)
PF00621
(RhoGEF) 		3 LEU A1041
VAL A1044
LEU A1048
 None
 0.51A 1mz9B-1foeA:
undetectable		 1mz9B-1foeA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g59 GLUTAMYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00749
(tRNA-synt_1c) 		3 LEU A 427
VAL A 430
LEU A 434
 C  B 534 ( 3.6A)
None
None
 0.38A 1mz9B-1g59A:
undetectable		 1mz9B-1g59A:
5.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3g CYCLOMALTODEXTRINASE

(Flavobacterium
sp. 92) 		PF00128
(Alpha-amylase)
PF09087
(Cyc-maltodext_N)
PF10438
(Cyc-maltodext_C) 		3 LEU A 391
VAL A 394
LEU A 398
 None
 0.53A 1mz9B-1h3gA:
undetectable		 1mz9B-1h3gA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbr PROTEIN (HEMOGLOBIN
D)

(Gallus gallus) 		PF00042
(Globin) 		3 LEU A 129
VAL A 132
LEU A 136
 None
 0.50A 1mz9B-1hbrA:
undetectable		 1mz9B-1hbrA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hci ALPHA-ACTININ 2

(Homo sapiens) 		PF00435
(Spectrin) 		3 LEU A 434
VAL A 437
LEU A 441
 None
 0.52A 1mz9B-1hciA:
undetectable		 1mz9B-1hciA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		3 LEU P 128
VAL P 131
LEU P 135
 None
 0.33A 1mz9B-1hynP:
undetectable		 1mz9B-1hynP:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 LEU A 242
VAL A 245
LEU A 249
 None
 0.47A 1mz9B-1i0aA:
undetectable		 1mz9B-1i0aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9g HYPOTHETICAL PROTEIN
RV2118C

(Mycobacterium
tuberculosis) 		PF08704
(GCD14)
PF14801
(GCD14_N) 		3 LEU A 186
VAL A 189
LEU A 193
 None
 0.30A 1mz9B-1i9gA:
undetectable		 1mz9B-1i9gA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iyv DIHYDROLIPOAMIDE
ACETYLTRANSFERASE
COMPONENT OF
PYRUVATE
DEHYDROGENASE
COMPLEX

(Azotobacter
vinelandii) 		PF00364
(Biotin_lipoyl) 		3 LEU A  35
VAL A  44
LEU A  32
 None
 0.52A 1mz9B-1iyvA:
undetectable		 1mz9B-1iyvA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j5w GLYCYL-TRNA
SYNTHETASE ALPHA
CHAIN

(Thermotoga
maritima) 		PF02091
(tRNA-synt_2e) 		3 LEU A   3
VAL A   6
LEU A  10
 None
 0.53A 1mz9B-1j5wA:
undetectable		 1mz9B-1j5wA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgf P450 MONOOXYGENASE

(Amycolatopsis
orientalis) 		PF00067
(p450) 		3 LEU A 357
VAL A 360
LEU A 364
 None
 0.49A 1mz9B-1lgfA:
undetectable		 1mz9B-1lgfA:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lia R-PHYCOERYTHRIN

(Polysiphonia
urceolata) 		PF00502
(Phycobilisome) 		3 LEU B  92
VAL B  95
LEU B  99
 None
 0.45A 1mz9B-1liaB:
undetectable		 1mz9B-1liaB:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		3 LEU A 321
VAL A 324
LEU A 328
 None
 0.48A 1mz9B-1lnzA:
undetectable		 1mz9B-1lnzA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LEU B 173
VAL B 176
LEU B 180
 None
 0.40A 1mz9B-1m1jB:
3.5		 1mz9B-1m1jB:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 LEU A 212
VAL A 215
LEU A 219
 None
 0.53A 1mz9B-1mc8A:
undetectable		 1mz9B-1mc8A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nf1 PROTEIN
(NEUROFIBROMIN)

(Homo sapiens) 		PF00616
(RasGAP) 		3 LEU A1361
VAL A1364
LEU A1368
 None
 0.47A 1mz9B-1nf1A:
undetectable		 1mz9B-1nf1A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nub BASEMENT MEMBRANE
PROTEIN BM-40

(Homo sapiens) 		PF00050
(Kazal_1)
PF09289
(FOLN)
PF10591
(SPARC_Ca_bdg) 		3 LEU A 154
VAL A 157
LEU A 161
 None
 0.53A 1mz9B-1nubA:
undetectable		 1mz9B-1nubA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzn FISSION PROTEIN
FIS1P

(Homo sapiens) 		PF14852
(Fis1_TPR_N)
PF14853
(Fis1_TPR_C) 		3 LEU A  94
VAL A  97
LEU A 101
 None
 0.51A 1mz9B-1nznA:
undetectable		 1mz9B-1nznA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5t TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 LEU A 434
VAL A 437
LEU A 441
 None
 0.44A 1mz9B-1o5tA:
undetectable		 1mz9B-1o5tA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osn THYMIDINE KINASE

(Human
alphaherpesvirus
3) 		PF00693
(Herpes_TK) 		3 LEU A 202
VAL A 205
LEU A 209
 None
 0.50A 1mz9B-1osnA:
undetectable		 1mz9B-1osnA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		3 LEU A 190
VAL A 193
LEU A 197
 None
 0.32A 1mz9B-1p49A:
undetectable		 1mz9B-1p49A:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p50 ARGININE KINASE

(Limulus
polyphemus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		3 LEU A 239
VAL A 242
LEU A 246
 None
 0.47A 1mz9B-1p50A:
undetectable		 1mz9B-1p50A:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS

(Burkholderia
pseudomallei) 		PF01007
(IRK) 		3 LEU A  70
VAL A  73
LEU A  77
 None
 0.22A 1mz9B-1p7bA:
undetectable		 1mz9B-1p7bA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1phz PROTEIN
(PHENYLALANINE
HYDROXYLASE)

(Rattus
norvegicus) 		PF00351
(Biopterin_H)
PF01842
(ACT) 		3 LEU A 227
VAL A 230
LEU A 234
 None
 0.46A 1mz9B-1phzA:
undetectable		 1mz9B-1phzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjm IMPORTIN ALPHA-2
SUBUNIT

(Mus musculus) 		PF00514
(Arm)
PF16186
(Arm_3) 		3 LEU B 307
VAL B 310
LEU B 314
 None
 0.43A 1mz9B-1pjmB:
undetectable		 1mz9B-1pjmB:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ps6 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF04166
(PdxA) 		3 LEU A 181
VAL A 184
LEU A 188
 None
 0.41A 1mz9B-1ps6A:
undetectable		 1mz9B-1ps6A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 LEU A 513
VAL A 511
LEU A 475
 None
 0.00A 1mz9B-1q5aA:
undetectable		 1mz9B-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhf PROTEIN
(PHOSPHOGLYCERATE
MUTASE)

(Saccharomyces
cerevisiae) 		PF00300
(His_Phos_1) 		3 LEU A 151
VAL A 154
LEU A 158
 None
 0.50A 1mz9B-1qhfA:
undetectable		 1mz9B-1qhfA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r62 NITROGEN REGULATION
PROTEIN NR(II)

(Escherichia
coli) 		PF02518
(HATPase_c) 		3 LEU A 243
VAL A 246
LEU A 250
 None
 0.51A 1mz9B-1r62A:
undetectable		 1mz9B-1r62A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6u TRYPTOPHANYL-TRNA
SYNTHETASE

(Homo sapiens) 		PF00579
(tRNA-synt_1b) 		3 LEU A 434
VAL A 437
LEU A 441
 None
 0.45A 1mz9B-1r6uA:
undetectable		 1mz9B-1r6uA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru1 2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE

(Escherichia
coli) 		PF01288
(HPPK) 		3 LEU A  15
VAL A  18
LEU A  22
 None
 0.53A 1mz9B-1ru1A:
undetectable		 1mz9B-1ru1A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s0h HEMOGLOBIN ALPHA
CHAIN

(Equus asinus) 		PF00042
(Globin) 		3 LEU A 129
VAL A 132
LEU A 136
 None
 0.51A 1mz9B-1s0hA:
undetectable		 1mz9B-1s0hA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 LEU A 283
VAL A 286
LEU A 290
 None
 0.51A 1mz9B-1sqgA:
undetectable		 1mz9B-1sqgA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae) 		PF03358
(FMN_red) 		3 LEU A 136
VAL A 139
LEU A 143
 None
 0.50A 1mz9B-1t0iA:
undetectable		 1mz9B-1t0iA:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1td6 HYPOTHETICAL PROTEIN
MG237 HOMOLOG

(Mycoplasma
pneumoniae) 		PF11428
(DUF3196) 		3 LEU A  88
VAL A  91
LEU A  95
 None
 0.51A 1mz9B-1td6A:
undetectable		 1mz9B-1td6A:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ttw SECRETION CHAPERONE

(Yersinia pestis) 		PF05932
(CesT) 		3 LEU A 105
VAL A 108
LEU A 112
 None
 0.49A 1mz9B-1ttwA:
undetectable		 1mz9B-1ttwA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u1h 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Arabidopsis
thaliana) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		3 LEU A  34
VAL A  37
LEU A  41
 None
 0.42A 1mz9B-1u1hA:
undetectable		 1mz9B-1u1hA:
4.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u4q SPECTRIN ALPHA
CHAIN, BRAIN

(Gallus gallus) 		PF00435
(Spectrin) 		3 LEU A1695
VAL A1698
LEU A1702
 None
 0.47A 1mz9B-1u4qA:
undetectable		 1mz9B-1u4qA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub9 HYPOTHETICAL PROTEIN
PH1061

(Pyrococcus
horikoshii) 		PF13601
(HTH_34) 		3 LEU A  91
VAL A  94
LEU A  98
 None
 0.51A 1mz9B-1ub9A:
undetectable		 1mz9B-1ub9A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usd VASODILATOR-STIMULAT
ED PHOSPHOPROTEIN

(Homo sapiens) 		PF08776
(VASP_tetra) 		3 LEU A 344
VAL A 347
LEU A 351
 None
 0.51A 1mz9B-1usdA:
4.7		 1mz9B-1usdA:
26.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 LEU A 402
VAL A 405
LEU A 409
 None
 0.52A 1mz9B-1v4gA:
undetectable		 1mz9B-1v4gA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v4g GLUTAMATE--CYSTEINE
LIGASE

(Escherichia
coli) 		PF04262
(Glu_cys_ligase) 		3 LEU A 413
VAL A 416
LEU A 420
 None
 0.50A 1mz9B-1v4gA:
undetectable		 1mz9B-1v4gA:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7n THROMBOPOIETIN

(Homo sapiens) 		PF00758
(EPO_TPO) 		3 LEU V  64
VAL V  67
LEU V  71
 None
 0.49A 1mz9B-1v7nV:
undetectable		 1mz9B-1v7nV:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc2 GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 LEU A 154
VAL A 157
LEU A 161
 None
 0.53A 1mz9B-1vc2A:
undetectable		 1mz9B-1vc2A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wch PROTEIN TYROSINE
PHOSPHATASE,
NON-RECEPTOR TYPE 13

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 LEU A2197
VAL A2200
LEU A2204
 None
 0.51A 1mz9B-1wchA:
undetectable		 1mz9B-1wchA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdi HYPOTHETICAL PROTEIN
TT0907

(Thermus
thermophilus) 		PF02547
(Queuosine_synth) 		3 LEU A 309
VAL A 312
LEU A 316
 None
 0.42A 1mz9B-1wdiA:
undetectable		 1mz9B-1wdiA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		3 LEU A 383
VAL A 386
LEU A 390
 None
 0.52A 1mz9B-1xa6A:
undetectable		 1mz9B-1xa6A:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		3 LEU A 210
VAL A 213
LEU A 217
 None
 0.51A 1mz9B-1xfbA:
undetectable		 1mz9B-1xfbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xg0 B-PHYCOERYTHRIN BETA
CHAIN

(Rhodomonas sp.
CS24) 		PF00502
(Phycobilisome) 		3 LEU C  90
VAL C  93
LEU C  97
 None
 0.44A 1mz9B-1xg0C:
undetectable		 1mz9B-1xg0C:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr5 GENOME POLYPROTEIN

(Rhinovirus B) 		PF00680
(RdRP_1) 		3 LEU A 249
VAL A 252
LEU A 256
 None
 0.35A 1mz9B-1xr5A:
undetectable		 1mz9B-1xr5A:
6.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ykd ADENYLATE CYCLASE

(Anabaena sp.) 		PF01590
(GAF) 		3 LEU A  65
VAL A  68
LEU A  72
 None
 0.52A 1mz9B-1ykdA:
undetectable		 1mz9B-1ykdA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqf HYPOTHETICAL PROTEIN
LMAJ011689

(Leishmania
major) 		PF02330
(MAM33) 		3 LEU A 151
VAL A 154
LEU A 158
 None
 0.39A 1mz9B-1yqfA:
undetectable		 1mz9B-1yqfA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxo 4-HYDROXYTHREONINE-4
-PHOSPHATE
DEHYDROGENASE 1

(Pseudomonas
aeruginosa) 		PF04166
(PdxA) 		3 LEU A1180
VAL A1183
LEU A1187
 None
 0.43A 1mz9B-1yxoA:
undetectable		 1mz9B-1yxoA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LEU A 671
VAL A 674
LEU A 678
 None
 0.50A 1mz9B-1zcjA:
undetectable		 1mz9B-1zcjA:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk8 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF13305
(WHG) 		3 LEU A  52
VAL A  55
LEU A  59
 None
 0.41A 1mz9B-1zk8A:
undetectable		 1mz9B-1zk8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a26 CALCYCLIN-BINDING
PROTEIN

(Homo sapiens) 		PF09032
(Siah-Interact_N) 		3 LEU A  10
VAL A  13
LEU A  17
 None
 0.41A 1mz9B-2a26A:
1.9		 1mz9B-2a26A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9j BISPHOSPHOGLYCERATE
MUTASE

(Homo sapiens) 		PF00300
(His_Phos_1) 		3 LEU A 158
VAL A 161
LEU A 165
 None
 0.52A 1mz9B-2a9jA:
undetectable		 1mz9B-2a9jA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		3 LEU A 250
VAL A 253
LEU A 257
 None
 0.36A 1mz9B-2aa4A:
undetectable		 1mz9B-2aa4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 LEU A  73
VAL A  76
LEU A  80
 None
 0.37A 1mz9B-2aazA:
undetectable		 1mz9B-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2am2 UDP-N-ACETYLMURAMOYL
ALANINE-D-GLUTAMYL-L
YSINE-D-ALANYL-D-ALA
NINE LIGASE, MURF
PROTEIN

(Streptococcus
pneumoniae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		3 LEU A 302
VAL A 269
LEU A 254
 None
 0.52A 1mz9B-2am2A:
undetectable		 1mz9B-2am2A:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2amc PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Thermus
thermophilus) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 LEU B 498
VAL B 501
LEU B 505
 None
 0.40A 1mz9B-2amcB:
undetectable		 1mz9B-2amcB:
4.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b22 GENERAL CONTROL
PROTEIN GCN4

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A   5
VAL A   8
LEU A  12
 None
 0.54A 1mz9B-2b22A:
undetectable		 1mz9B-2b22A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b22 GENERAL CONTROL
PROTEIN GCN4

(Saccharomyces
cerevisiae) 		no annotation 3 LEU A  12
VAL A  15
LEU A  19
 None
 0.37A 1mz9B-2b22A:
undetectable		 1mz9B-2b22A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		3 LEU I 292
VAL I 295
LEU I 299
 None
 0.32A 1mz9B-2b4xI:
undetectable		 1mz9B-2b4xI:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		3 LEU A 453
VAL A 456
LEU A 460
 None
 0.48A 1mz9B-2b9bA:
undetectable		 1mz9B-2b9bA:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9c STRIATED-MUSCLE
ALPHA TROPOMYOSIN

(Rattus
norvegicus) 		PF00261
(Tropomyosin) 		3 LEU A 197
VAL A 200
LEU A 204
 None
 0.36A 1mz9B-2b9cA:
undetectable		 1mz9B-2b9cA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv8 C-PHYCOCYANIN ALPHA
SUBUNIT

(Gracilaria
chilensis) 		PF00502
(Phycobilisome) 		3 LEU A  92
VAL A  95
LEU A  99
 None
 0.53A 1mz9B-2bv8A:
undetectable		 1mz9B-2bv8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Rattus
norvegicus) 		PF03114
(BAR) 		3 LEU A 233
VAL A 236
LEU A 240
 None
 0.53A 1mz9B-2c08A:
undetectable		 1mz9B-2c08A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cun PHOSPHOGLYCERATE
KINASE

(Pyrococcus
horikoshii) 		PF00162
(PGK) 		3 LEU A 159
VAL A 394
LEU A 392
 None
 0.48A 1mz9B-2cunA:
undetectable		 1mz9B-2cunA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhr FTSH

(Thermus
thermophilus) 		PF00004
(AAA)
PF01434
(Peptidase_M41) 		3 LEU A 569
VAL A 572
LEU A 576
 None
 0.41A 1mz9B-2dhrA:
undetectable		 1mz9B-2dhrA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di4 CELL DIVISION
PROTEIN FTSH HOMOLOG

(Aquifex
aeolicus) 		PF01434
(Peptidase_M41) 		3 LEU A 573
VAL A 576
LEU A 580
 None
 0.43A 1mz9B-2di4A:
undetectable		 1mz9B-2di4A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2djz 235AA LONG
HYPOTHETICAL
BIOTIN-[ACETYL-COA-C
ARBOXYLASE] LIGASE

(Pyrococcus
horikoshii) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		3 LEU A 153
VAL A 156
LEU A 160
 None
 0.24A 1mz9B-2djzA:
undetectable		 1mz9B-2djzA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq3 SERYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		3 LEU A  91
VAL A  94
LEU A  98
 None
 0.45A 1mz9B-2dq3A:
undetectable		 1mz9B-2dq3A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dsq INSULIN-LIKE GROWTH
FACTOR-BINDING
PROTEIN 1

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		3 LEU G 155
VAL G 158
LEU G 162
 None
 0.52A 1mz9B-2dsqG:
undetectable		 1mz9B-2dsqG:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f06 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 3 LEU A  83
VAL A  86
LEU A  90
 HIS  A 152 (-3.7A)
None
None
 0.53A 1mz9B-2f06A:
undetectable		 1mz9B-2f06A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f8n HISTONE H2A TYPE 1

(Mus musculus) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		3 LEU K  51
VAL K  54
LEU K  58
 None
 0.48A 1mz9B-2f8nK:
undetectable		 1mz9B-2f8nK:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		3 LEU A 236
VAL A 239
LEU A 243
 None
 0.50A 1mz9B-2f9tA:
undetectable		 1mz9B-2f9tA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g18 PHYCOCYANOBILIN:FERR
EDOXIN
OXIDOREDUCTASE

(Anabaena sp.) 		PF05996
(Fe_bilin_red) 		3 LEU A 174
VAL A 177
LEU A 181
 None
 0.47A 1mz9B-2g18A:
undetectable		 1mz9B-2g18A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		3 LEU A 415
VAL A 420
LEU A 423
 None
 0.53A 1mz9B-2gduA:
undetectable		 1mz9B-2gduA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gti REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF06471
(NSP11) 		3 LEU A   2
VAL A   5
LEU A   9
 None
 0.37A 1mz9B-2gtiA:
undetectable		 1mz9B-2gtiA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hd7 TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		3 LEU A 190
VAL A 283
LEU A 280
 None
 0.42A 1mz9B-2hd7A:
undetectable		 1mz9B-2hd7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hh7 HYPOTHETICAL PROTEIN
CSOR

(Mycobacterium
tuberculosis) 		PF02583
(Trns_repr_metal) 		3 LEU A  16
VAL A  19
LEU A  23
 None
 0.51A 1mz9B-2hh7A:
undetectable		 1mz9B-2hh7A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a81 SYK KINASE

(Homo sapiens) 		PF00017
(SH2) 		3 THR A 256
LEU A 255
LEU A 237
 None
 0.59A 1mz9C-1a81A:
undetectable		 1mz9C-1a81A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aos ARGININOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 128
LEU A 132
LEU A 139
 None
 0.63A 1mz9C-1aosA:
undetectable		 1mz9C-1aosA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		3 THR A  54
LEU A  32
LEU A  25
 None
 0.54A 1mz9C-1ayeA:
undetectable		 1mz9C-1ayeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)

(Mycobacterium
leprae) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 THR A  37
LEU A  38
LEU A  10
 None
 0.58A 1mz9C-1bvsA:
undetectable		 1mz9C-1bvsA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 3 THR A  61
LEU A  65
LEU A  72
 None
 0.58A 1mz9C-1bwdA:
undetectable		 1mz9C-1bwdA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3x PENTOSYLTRANSFERASE

(Cellulomonas
sp.) 		PF01048
(PNP_UDP_1) 		3 THR A 189
LEU A 190
LEU A 151
 None
 0.66A 1mz9C-1c3xA:
undetectable		 1mz9C-1c3xA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d3y DNA TOPOISOMERASE VI
A SUBUNIT

(Methanocaldococcus
jannaschii) 		PF04406
(TP6A_N) 		3 THR A  79
LEU A  83
LEU A  90
 None
 0.62A 1mz9C-1d3yA:
undetectable		 1mz9C-1d3yA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dmu BGLI RESTRICTION
ENDONUCLEASE

(Bacillus
subtilis) 		PF14562
(Endonuc_BglI) 		3 THR A 113
LEU A 111
LEU A 120
 None
 0.54A 1mz9C-1dmuA:
undetectable		 1mz9C-1dmuA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		3 THR A 108
LEU A 112
LEU A 119
 None
 0.63A 1mz9C-1eg3A:
undetectable		 1mz9C-1eg3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 THR A  21
LEU A  25
LEU A  32
 None
 0.37A 1mz9C-1ehkA:
undetectable		 1mz9C-1ehkA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewk METABOTROPIC
GLUTAMATE RECEPTOR
SUBTYPE 1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		3 THR A 295
LEU A 299
LEU A 306
 None
 0.61A 1mz9C-1ewkA:
undetectable		 1mz9C-1ewkA:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f1x HOMOPROTOCATECHUATE
2,3-DIOXYGENASE

(Brevibacterium
fuscum) 		PF00903
(Glyoxalase) 		3 THR A 219
LEU A 150
LEU A  64
 None
 0.44A 1mz9C-1f1xA:
undetectable		 1mz9C-1f1xA:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f3b GLUTATHIONE
S-TRANSFERASE YA
CHAIN

(Mus musculus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 THR A 127
LEU A 132
LEU A 139
 None
 0.66A 1mz9C-1f3bA:
undetectable		 1mz9C-1f3bA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f59 IMPORTIN BETA-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 THR A 150
LEU A 151
LEU A 198
 None
 0.62A 1mz9C-1f59A:
undetectable		 1mz9C-1f59A:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		3 THR A 205
LEU A 209
LEU A 216
 None
 0.63A 1mz9C-1fbaA:
undetectable		 1mz9C-1fbaA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		3 THR A1205
LEU A1209
LEU A1216
 None
 0.63A 1mz9C-1fdjA:
undetectable		 1mz9C-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1few SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		3 THR A  30
LEU A  34
LEU A  41
 None
 0.56A 1mz9C-1fewA:
undetectable		 1mz9C-1fewA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxi FERREDOXIN I

(Aphanothece
sacrum) 		PF00111
(Fer2) 		3 THR A  76
LEU A  75
LEU A  64
 None
FES  A  97 (-4.1A)
None
 0.58A 1mz9C-1fxiA:
undetectable		 1mz9C-1fxiA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxk PROTEIN (PREFOLDIN)

(Methanothermobacter
thermautotrophicus) 		PF02996
(Prefoldin) 		3 THR C  34
LEU C  38
LEU C  45
 None
 0.57A 1mz9C-1fxkC:
2.1		 1mz9C-1fxkC:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g73 SECOND
MITOCHONDRIA-DERIVED
ACTIVATOR OF
CASPASES

(Homo sapiens) 		PF09057
(Smac_DIABLO) 		3 THR A  30
LEU A  34
LEU A  41
 None
 0.53A 1mz9C-1g73A:
2.2		 1mz9C-1g73A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1

(Mus musculus) 		PF12352
(V-SNARE_C) 		3 THR C 177
LEU C 181
LEU C 188
 None
 0.54A 1mz9C-1gl2C:
4.4		 1mz9C-1gl2C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 VESICLE TRANSPORT
V-SNARE PROTEIN
VTI1-LIKE 1

(Mus musculus) 		PF12352
(V-SNARE_C) 		3 THR C 184
LEU C 188
LEU C 195
 None
 0.58A 1mz9C-1gl2C:
4.4		 1mz9C-1gl2C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gs9 APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 THR A  67
LEU A  71
LEU A  78
 None
 0.66A 1mz9C-1gs9A:
undetectable		 1mz9C-1gs9A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzk RAC-BETA
SERINE/THREONINE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 THR A 372
LEU A 373
LEU A 380
 None
 0.64A 1mz9C-1gzkA:
undetectable		 1mz9C-1gzkA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h65 CHLOROPLAST OUTER
ENVELOPE PROTEIN
OEP34

(Pisum sativum) 		PF04548
(AIG1) 		3 THR A  21
LEU A  25
LEU A  32
 None
 0.65A 1mz9C-1h65A:
undetectable		 1mz9C-1h65A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm6 ANNEXIN 1

(Sus scrofa) 		PF00191
(Annexin) 		3 THR A 136
LEU A 137
LEU A 181
 None
 0.63A 1mz9C-1hm6A:
undetectable		 1mz9C-1hm6A:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		3 THR A 181
LEU A 185
LEU A 192
 None
 0.65A 1mz9C-1hx8A:
undetectable		 1mz9C-1hx8A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iaw TYPE II RESTRICTION
ENZYME NAEI

(Lechevalieria
aerocolonigenes) 		PF09126
(NaeI) 		3 THR A  32
LEU A  36
LEU A  43
 None
 0.61A 1mz9C-1iawA:
undetectable		 1mz9C-1iawA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ic2 TROPOMYOSIN ALPHA
CHAIN, SKELETAL
MUSCLE

(Gallus gallus) 		PF12718
(Tropomyosin_1) 		3 THR A  53
LEU A  57
LEU A  64
 None
 0.49A 1mz9C-1ic2A:
3.7		 1mz9C-1ic2A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3j BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00303
(Thymidylat_synt) 		3 THR C 370
LEU C 369
LEU C 514
 None
 0.66A 1mz9C-1j3jC:
undetectable		 1mz9C-1j3jC:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jun C-JUN HOMODIMER

(Homo sapiens) 		PF00170
(bZIP_1) 		3 THR A 297
LEU A 301
LEU A 308
 None
 0.63A 1mz9C-1junA:
4.7		 1mz9C-1junA:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 THR A  95
LEU A  99
LEU A 106
 DND  A 301 (-3.9A)
None
None
 0.52A 1mz9C-1kqoA:
undetectable		 1mz9C-1kqoA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		3 THR A 640
LEU A 641
LEU A 626
 None
 0.66A 1mz9C-1l5jA:
undetectable		 1mz9C-1l5jA:
5.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpe APOLIPOPROTEIN E3

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 THR A  67
LEU A  71
LEU A  78
 None
 0.62A 1mz9C-1lpeA:
undetectable		 1mz9C-1lpeA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lvf SYNTAXIN 6

(Rattus
norvegicus) 		PF09177
(Syntaxin-6_N) 		3 THR A  20
LEU A  24
LEU A  31
 None
 0.61A 1mz9C-1lvfA:
2.4		 1mz9C-1lvfA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwd ISOCITRATE
DEHYDROGENASE

(Sus scrofa) 		PF00180
(Iso_dh) 		3 THR A 395
LEU A 399
LEU A 406
 None
 0.56A 1mz9C-1lwdA:
undetectable		 1mz9C-1lwdA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN GAMMA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 THR C  36
LEU C  40
LEU C  47
 None
 0.39A 1mz9C-1m1jC:
3.8		 1mz9C-1m1jC:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m76 3-HYDROXYACYL-COA
DEHYDROGENASE

(Homo sapiens) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 THR A 181
LEU A 185
LEU A 192
 None
 0.65A 1mz9C-1m76A:
undetectable		 1mz9C-1m76A:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		3 THR A 246
LEU A 116
LEU A 161
 None
 0.64A 1mz9C-1mg1A:
3.5		 1mz9C-1mg1A:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg7 EARLY SWITCH PROTEIN
XOL-1 2.2K SPLICE
FORM

(Caenorhabditis
elegans) 		PF09108
(Xol-1_N)
PF09109
(Xol-1_GHMP-like) 		3 THR A 100
LEU A 104
LEU A 111
 None
 0.59A 1mz9C-1mg7A:
undetectable		 1mz9C-1mg7A:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n1q DPS PROTEIN

(Brevibacillus
brevis) 		PF00210
(Ferritin) 		3 THR A  59
LEU A  60
LEU A  12
 None
 0.61A 1mz9C-1n1qA:
undetectable		 1mz9C-1n1qA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n8p CYSTATHIONINE
GAMMA-LYASE

(Saccharomyces
cerevisiae) 		PF01053
(Cys_Met_Meta_PP) 		3 THR A 377
LEU A 381
LEU A 388
 None
 0.54A 1mz9C-1n8pA:
undetectable		 1mz9C-1n8pA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT

(Methanothermobacter
thermautotrophicus) 		PF01873
(eIF-5_eIF-2B) 		3 THR A  68
LEU A  66
LEU A  59
 None
 0.49A 1mz9C-1neeA:
undetectable		 1mz9C-1neeA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nlu SEDOLISIN

(Pseudomonas sp.) 		no annotation 3 THR A  41
LEU A  45
LEU A  54
 None
 0.55A 1mz9C-1nluA:
undetectable		 1mz9C-1nluA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 THR A 190
LEU A 189
LEU A 102
 None
 0.64A 1mz9C-1nr9A:
undetectable		 1mz9C-1nr9A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 THR A  93
LEU A  97
LEU A 104
 NXX  A 401 (-4.3A)
None
None
 0.57A 1mz9C-1nuqA:
undetectable		 1mz9C-1nuqA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot8 NEUROGENIC LOCUS
NOTCH PROTEIN

(Drosophila
melanogaster) 		PF12796
(Ank_2) 		3 THR A  46
LEU A  43
LEU A  36
 None
 0.53A 1mz9C-1ot8A:
undetectable		 1mz9C-1ot8A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1otk PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAC

(Escherichia
coli) 		PF05138
(PaaA_PaaC) 		3 THR A   6
LEU A  10
LEU A  17
 None
 0.51A 1mz9C-1otkA:
undetectable		 1mz9C-1otkA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pbw PHOSPHATIDYLINOSITOL
3-KINASE

(Homo sapiens) 		PF00620
(RhoGAP) 		3 THR A 239
LEU A 243
LEU A 250
 None
 0.64A 1mz9C-1pbwA:
undetectable		 1mz9C-1pbwA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pjb L-ALANINE
DEHYDROGENASE

(Phormidium
lapideum) 		PF01262
(AlaDh_PNT_C)
PF05222
(AlaDh_PNT_N) 		3 THR A 309
LEU A 312
LEU A 129
 None
 0.66A 1mz9C-1pjbA:
undetectable		 1mz9C-1pjbA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 THR A 407
LEU A 428
LEU A 345
 NAG  A 808 (-2.2A)
None
None
 0.55A 1mz9C-1q5aA:
undetectable		 1mz9C-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 THR A 335
LEU A 339
LEU A 346
 None
 0.66A 1mz9C-1q5nA:
undetectable		 1mz9C-1q5nA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7s BIT1

(Homo sapiens) 		PF01981
(PTH2) 		3 THR A 125
LEU A 129
LEU A 136
 None
 0.66A 1mz9C-1q7sA:
undetectable		 1mz9C-1q7sA:
25.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		3 THR A 126
LEU A 127
LEU A 167
 None
 0.62A 1mz9C-1qapA:
undetectable		 1mz9C-1qapA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qf7 PROTEIN (CATALASE
HPII)

(Escherichia
coli) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 THR A 734
LEU A 735
LEU A 692
 None
 0.60A 1mz9C-1qf7A:
undetectable		 1mz9C-1qf7A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		3 THR A 150
LEU A 151
LEU A 198
 None
 0.55A 1mz9C-1qgrA:
undetectable		 1mz9C-1qgrA:
4.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcd L FERRITIN

(Rana
catesbeiana) 		PF00210
(Ferritin) 		3 THR A 140
LEU A 144
LEU A 151
 None
 0.40A 1mz9C-1rcdA:
undetectable		 1mz9C-1rcdA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rh9 ENDO-BETA-MANNANASE

(Solanum
lycopersicum) 		PF00150
(Cellulase) 		3 THR A 275
LEU A 315
LEU A  47
 None
 0.66A 1mz9C-1rh9A:
undetectable		 1mz9C-1rh9A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		3 THR A 199
LEU A 203
LEU A 210
 None
 0.41A 1mz9C-1rtrA:
undetectable		 1mz9C-1rtrA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svi GTP-BINDING PROTEIN
YSXC

(Bacillus
subtilis) 		PF01926
(MMR_HSR1) 		3 THR A 162
LEU A 163
LEU A 130
 None
 0.46A 1mz9C-1sviA:
undetectable		 1mz9C-1sviA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1u CHOLINE
O-ACETYLTRANSFERASE

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		3 THR A 383
LEU A 387
LEU A 394
 None
 0.55A 1mz9C-1t1uA:
undetectable		 1mz9C-1t1uA:
5.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3j MITOFUSIN 1

(Mus musculus) 		PF04799
(Fzo_mitofusin) 		3 THR A 687
LEU A 691
LEU A 698
 None
 0.65A 1mz9C-1t3jA:
4.2		 1mz9C-1t3jA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t98 CHROMOSOME PARTITION
PROTEIN MUKF

(Escherichia
coli) 		PF03882
(KicB)
PF17192
(MukF_M) 		3 THR A 211
LEU A 215
LEU A 222
 None
 0.59A 1mz9C-1t98A:
undetectable		 1mz9C-1t98A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj7 ARGININOSUCCINATE
LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 124
LEU A 128
LEU A 135
 None
 0.58A 1mz9C-1tj7A:
undetectable		 1mz9C-1tj7A:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1unl CYCLIN-DEPENDENT
KINASE 5 ACTIVATOR 1

(Homo sapiens) 		PF03261
(CDK5_activator) 		3 THR D 148
LEU D 152
LEU D 159
 None
 0.63A 1mz9C-1unlD:
undetectable		 1mz9C-1unlD:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT

(Mycobacterium
tuberculosis) 		PF00268
(Ribonuc_red_sm) 		3 THR A 219
LEU A 223
LEU A 230
 CIT  A1294 ( 3.6A)
CIT  A1294 (-4.5A)
None
 0.21A 1mz9C-1uzrA:
undetectable		 1mz9C-1uzrA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vs1 3-DEOXY-7-PHOSPHOHEP
TULONATE SYNTHASE

(Aeropyrum
pernix) 		PF00793
(DAHP_synth_1) 		3 THR A 259
LEU A 258
LEU A 239
 None
 0.59A 1mz9C-1vs1A:
undetectable		 1mz9C-1vs1A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w2w 5-METHYLTHIORIBOSE-1
-PHOSPHATE ISOMERASE

(Saccharomyces
cerevisiae) 		PF01008
(IF-2B) 		3 THR A  91
LEU A  95
LEU A 102
 None
 0.39A 1mz9C-1w2wA:
undetectable		 1mz9C-1w2wA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxj TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Thermus
thermophilus) 		PF00290
(Trp_syntA) 		3 THR A 121
LEU A  94
LEU A  22
 None
 0.64A 1mz9C-1wxjA:
undetectable		 1mz9C-1wxjA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3s RAS-RELATED PROTEIN
RAB-18

(Homo sapiens) 		PF00071
(Ras) 		3 THR A  95
LEU A  99
LEU A 106
 None
 0.64A 1mz9C-1x3sA:
undetectable		 1mz9C-1x3sA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE

(Bacillus
subtilis) 		PF01515
(PTA_PTB) 		3 THR A 142
LEU A 295
LEU A 121
 None
 0.53A 1mz9C-1xcoA:
undetectable		 1mz9C-1xcoA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdz METHYLTRANSFERASE
GIDB

(Bacillus
subtilis) 		PF02527
(GidB) 		3 THR A 190
LEU A 191
LEU A 162
 None
 0.59A 1mz9C-1xdzA:
undetectable		 1mz9C-1xdzA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xec DECORIN

(Bos taurus) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		3 THR A 239
LEU A 218
LEU A 173
 None
 0.58A 1mz9C-1xecA:
undetectable		 1mz9C-1xecA:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xhe AEROBIC RESPIRATION
CONTROL PROTEIN ARCA

(Escherichia
coli) 		PF00072
(Response_reg) 		3 THR A  18
LEU A  19
LEU A  50
 None
 0.57A 1mz9C-1xheA:
undetectable		 1mz9C-1xheA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xly SHE2P

(Saccharomyces
cerevisiae) 		PF11435
(She2p) 		3 THR A 109
LEU A 113
LEU A 121
 None
 0.48A 1mz9C-1xlyA:
undetectable		 1mz9C-1xlyA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xnf LIPOPROTEIN NLPI

(Escherichia
coli) 		PF07719
(TPR_2)
PF13181
(TPR_8) 		3 THR A 236
LEU A 240
LEU A 247
 None
 0.63A 1mz9C-1xnfA:
undetectable		 1mz9C-1xnfA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xq1 PUTATIVE TROPINONE
REDUCATSE

(Arabidopsis
thaliana) 		PF13561
(adh_short_C2) 		3 THR A 167
LEU A 171
LEU A 178
 None
 0.64A 1mz9C-1xq1A:
undetectable		 1mz9C-1xq1A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zgg PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE YWLE

(Bacillus
subtilis) 		PF01451
(LMWPc) 		3 THR A 130
LEU A 134
LEU A 141
 None
 0.65A 1mz9C-1zggA:
undetectable		 1mz9C-1zggA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlp PETAL DEATH PROTEIN

(Dianthus
caryophyllus) 		PF13714
(PEP_mutase) 		3 THR A 264
LEU A 268
LEU A 275
 None
 0.49A 1mz9C-1zlpA:
undetectable		 1mz9C-1zlpA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zov MONOMERIC SARCOSINE
OXIDASE

(Bacillus sp.
NS-129) 		PF01266
(DAO) 		3 THR A 356
LEU A 357
LEU A 197
 None
 0.61A 1mz9C-1zovA:
undetectable		 1mz9C-1zovA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		3 THR A 146
LEU A 150
LEU A 157
 None
 0.66A 1mz9C-2a9sA:
undetectable		 1mz9C-2a9sA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 THR A  67
LEU A  66
LEU A 220
 None
 0.54A 1mz9C-2aazA:
undetectable		 1mz9C-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		3 THR A 152
LEU A 156
LEU A 163
 None
 0.39A 1mz9C-2amlA:
undetectable		 1mz9C-2amlA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		3 THR A 136
LEU A 140
LEU A 147
 None
 0.44A 1mz9C-2c3nA:
undetectable		 1mz9C-2c3nA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		3 THR A 272
LEU A 377
LEU A  82
 None
 0.51A 1mz9C-2canA:
undetectable		 1mz9C-2canA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		3 THR A  10
LEU A  14
LEU A  21
 None
 0.47A 1mz9C-2cwoA:
undetectable		 1mz9C-2cwoA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2x 2-DEOXY-SCYLLO-INOSO
SE SYNTHASE

(Bacillus
circulans) 		PF01761
(DHQ_synthase) 		3 THR A  79
LEU A  83
LEU A  90
 None
 0.60A 1mz9C-2d2xA:
undetectable		 1mz9C-2d2xA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d57 AQUAPORIN-4

(Rattus
norvegicus) 		PF00230
(MIP) 		3 THR A  39
LEU A  43
LEU A  50
 None
 0.55A 1mz9C-2d57A:
undetectable		 1mz9C-2d57A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec2 136AA LONG
HYPOTHETICAL
TRANSPOSASE

(Sulfurisphaera
tokodaii) 		PF01797
(Y1_Tnp) 		3 THR A  36
LEU A  40
LEU A  47
 None
 0.65A 1mz9C-2ec2A:
undetectable		 1mz9C-2ec2A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ef4 ARGINASE

(Thermus
thermophilus) 		PF00491
(Arginase) 		3 THR A 274
LEU A 278
LEU A 285
 None
 0.54A 1mz9C-2ef4A:
undetectable		 1mz9C-2ef4A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		3 THR A 191
LEU A 195
LEU A 202
 None
 0.61A 1mz9C-2eijA:
undetectable		 1mz9C-2eijA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekf ANCIENT UBIQUITOUS
PROTEIN 1

(Homo sapiens) 		PF02845
(CUE) 		3 THR A  15
LEU A  16
LEU A  44
 None
 0.55A 1mz9C-2ekfA:
undetectable		 1mz9C-2ekfA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekl D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 THR A 299
LEU A 303
LEU A 310
 None
 0.63A 1mz9C-2eklA:
undetectable		 1mz9C-2eklA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5g TRANSPOSASE,
PUTATIVE

(Sulfolobus
solfataricus) 		PF01797
(Y1_Tnp) 		3 THR A  36
LEU A  40
LEU A  47
 None
 0.65A 1mz9C-2f5gA:
undetectable		 1mz9C-2f5gA:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6h MYOSIN-2

(Saccharomyces
cerevisiae) 		PF01843
(DIL) 		3 THR X 300
LEU X 299
LEU X 256
 None
 0.62A 1mz9C-2f6hX:
undetectable		 1mz9C-2f6hX:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2flh CYTOKININ-SPECIFIC
BINDING PROTEIN

(Vigna radiata) 		PF00407
(Bet_v_1) 		3 THR A 139
LEU A 143
LEU A 150
 ZEA  A 701 (-3.1A)
None
None
 0.64A 1mz9C-2flhA:
undetectable		 1mz9C-2flhA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnk SAM-DEPENDENT
O-METHYLTRANSFERASE

(Leptospira
interrogans) 		PF01596
(Methyltransf_3) 		3 THR A 124
LEU A 125
LEU A 171
 None
 0.57A 1mz9C-2hnkA:
undetectable		 1mz9C-2hnkA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzs RNA POLYMERASE II
MEDIATOR COMPLEX
SUBUNIT 18

(Saccharomyces
cerevisiae) 		PF09637
(Med18) 		3 THR B 271
LEU B 275
LEU B 282
 None
 0.65A 1mz9C-2hzsB:
undetectable		 1mz9C-2hzsB:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4g HYALURONOGLUCOSAMINI
DASE

(Bacteroides
thetaiotaomicron) 		PF02838
(Glyco_hydro_20b)
PF07555
(NAGidase) 		3 THR A 100
LEU A 104
LEU A 111
 None
 0.43A 1mz9C-2j4gA:
undetectable		 1mz9C-2j4gA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7p CELL DIVISION
PROTEIN FTSY

(Thermus
aquaticus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		3 THR D 118
LEU D 122
LEU D 129
 None
 0.64A 1mz9C-2j7pD:
undetectable		 1mz9C-2j7pD:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6j NITROGEN REGULATORY
IIA PROTEIN

(Escherichia
coli) 		PF00359
(PTS_EIIA_2) 		4 THR A 154
LEU A  10
VAL A 127
LEU A 124
 None
 0.90A 1mz9D-1a6jA:
undetectable		 1mz9D-1a6jA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1at3 HERPES SIMPLEX VIRUS
TYPE II PROTEASE

(Human
alphaherpesvirus
2) 		PF00716
(Peptidase_S21) 		4 THR A 210
LEU A 213
VAL A  59
LEU A 151
 None
 0.99A 1mz9D-1at3A:
undetectable		 1mz9D-1at3A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awc PROTEIN (GA BINDING
PROTEIN BETA 1)

(Mus musculus) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 THR B  54
LEU B  57
VAL B  22
LEU B  25
 None
 0.92A 1mz9D-1awcB:
undetectable		 1mz9D-1awcB:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 THR A  54
LEU A  32
VAL A  33
LEU A  25
 None
 0.86A 1mz9D-1ayeA:
undetectable		 1mz9D-1ayeA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dtd CARBOXYPEPTIDASE A2

(Homo sapiens) 		PF00246
(Peptidase_M14) 		4 THR A 410
LEU A 388
VAL A 389
LEU A 381
 None
 0.87A 1mz9D-1dtdA:
undetectable		 1mz9D-1dtdA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.60A 1mz9D-1fbaA:
undetectable		 1mz9D-1fbaA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A1205
LEU A1209
VAL A1212
LEU A1216
 None
 0.64A 1mz9D-1fdjA:
undetectable		 1mz9D-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 THR A 623
LEU A 619
VAL A 616
LEU A 612
 None
 0.99A 1mz9D-1h0hA:
undetectable		 1mz9D-1h0hA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6g TIP120 PROTEIN

(Homo sapiens) 		PF08623
(TIP120) 		4 THR C 611
LEU C 612
VAL C 647
LEU C 648
 None
 0.85A 1mz9D-1u6gC:
undetectable		 1mz9D-1u6gC:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w55 ISPD/ISPF
BIFUNCTIONAL ENZYME

(Campylobacter
jejuni) 		PF01128
(IspD)
PF02542
(YgbB) 		4 THR A  38
LEU A  41
VAL A 102
LEU A 106
 None
 0.82A 1mz9D-1w55A:
undetectable		 1mz9D-1w55A:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		4 THR A 144
LEU A 148
VAL A 151
LEU A 155
 PO4  A 501 (-3.9A)
None
None
None
 0.99A 1mz9D-1wekA:
undetectable		 1mz9D-1wekA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		4 THR A 206
LEU A 210
VAL A 213
LEU A 217
 None
 0.62A 1mz9D-1xfbA:
undetectable		 1mz9D-1xfbA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y3t HYPOTHETICAL PROTEIN
YXAG

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		4 THR A  34
LEU A  50
VAL A 115
LEU A  72
 None
 0.98A 1mz9D-1y3tA:
undetectable		 1mz9D-1y3tA:
8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		4 THR A 160
LEU A 164
VAL A 167
LEU A 171
 None
 0.86A 1mz9D-1y9uA:
undetectable		 1mz9D-1y9uA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		4 THR A  85
LEU A  89
VAL A  92
LEU A  96
 None
 0.85A 1mz9D-1yulA:
undetectable		 1mz9D-1yulA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a9s COMPETENCE/DAMAGE-IN
DUCIBLE PROTEIN CINA

(Agrobacterium
fabrum) 		PF02464
(CinA) 		4 THR A 146
LEU A 150
VAL A 153
LEU A 157
 None
 0.78A 1mz9D-2a9sA:
undetectable		 1mz9D-2a9sA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bl2 V-TYPE SODIUM ATP
SYNTHASE SUBUNIT K

(Enterococcus
hirae) 		PF00137
(ATP-synt_C) 		4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.79A 1mz9D-2bl2A:
undetectable		 1mz9D-2bl2A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekf ANCIENT UBIQUITOUS
PROTEIN 1

(Homo sapiens) 		PF02845
(CUE) 		4 THR A  15
LEU A  16
VAL A  42
LEU A  44
 None
 0.67A 1mz9D-2ekfA:
undetectable		 1mz9D-2ekfA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		4 THR A 103
LEU A 107
VAL A 110
LEU A 114
 None
 0.85A 1mz9D-2hujA:
undetectable		 1mz9D-2hujA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3t TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14633
(SH2_2) 		4 THR A 102
LEU A  98
VAL A  95
LEU A  91
 None
 0.81A 1mz9D-2l3tA:
undetectable		 1mz9D-2l3tA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nps SYNTAXIN-6

(Homo sapiens) 		no annotation 4 THR D 211
LEU D 215
VAL D 218
LEU D 222
 None
 0.65A 1mz9D-2npsD:
4.1		 1mz9D-2npsD:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okj GLUTAMATE
DECARBOXYLASE 1

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 113
LEU A 117
VAL A 120
LEU A 124
 None
 0.81A 1mz9D-2okjA:
undetectable		 1mz9D-2okjA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okk GLUTAMATE
DECARBOXYLASE 2

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		4 THR A 107
LEU A 111
VAL A 114
LEU A 118
 None
 0.87A 1mz9D-2okkA:
undetectable		 1mz9D-2okkA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		4 THR A 120
LEU A 124
VAL A 127
LEU A 131
 ADP  A 300 (-3.6A)
None
None
None
 0.79A 1mz9D-2pl3A:
undetectable		 1mz9D-2pl3A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0q ARYL ESTERASE

(Mycolicibacterium
smegmatis) 		PF13472
(Lipase_GDSL_2) 		4 THR A 161
LEU A 164
VAL A 167
LEU A 171
 None
 0.97A 1mz9D-2q0qA:
undetectable		 1mz9D-2q0qA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		4 THR A 394
LEU A 398
VAL A 401
LEU A 405
 None
 0.76A 1mz9D-2qfvA:
undetectable		 1mz9D-2qfvA:
7.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w83 C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 4

(Homo sapiens) 		PF16471
(JIP_LZII) 		4 THR C 409
LEU C 413
VAL C 416
LEU C 420
 None
 0.75A 1mz9D-2w83C:
4.2		 1mz9D-2w83C:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y69 CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1

(Bos taurus) 		PF02238
(COX7a) 		4 THR J  27
LEU J  31
VAL J  34
LEU J  38
 None
 0.78A 1mz9D-2y69J:
3.1		 1mz9D-2y69J:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb7 INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		4 THR A 130
LEU A 128
VAL A 308
LEU A 289
 None
 0.89A 1mz9D-3bb7A:
undetectable		 1mz9D-3bb7A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bba INTERPAIN A

(Prevotella
intermedia) 		PF01640
(Peptidase_C10) 		4 THR A 130
LEU A 128
VAL A 308
LEU A 289
 None
 0.91A 1mz9D-3bbaA:
undetectable		 1mz9D-3bbaA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		4 THR A 243
LEU A 247
VAL A 250
LEU A 254
 HEM  A 450 (-4.3A)
None
None
None
 0.79A 1mz9D-3bdzA:
undetectable		 1mz9D-3bdzA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		4 THR A 205
LEU A 209
VAL A 212
LEU A 216
 None
 0.70A 1mz9D-3bv4A:
undetectable		 1mz9D-3bv4A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 THR A 247
LEU A 251
VAL A 254
LEU A 258
 None
 0.79A 1mz9D-3c8tA:
undetectable		 1mz9D-3c8tA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 THR A 136
LEU A 140
VAL A 143
LEU A 147
 None
 0.76A 1mz9D-3cj1A:
undetectable		 1mz9D-3cj1A:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		4 THR A  84
LEU A  88
VAL A  91
LEU A  95
 None
 0.68A 1mz9D-3cskA:
1.4		 1mz9D-3cskA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3s L-2,4-DIAMINOBUTYRIC
ACID
ACETYLTRANSFERASE

(Bordetella
parapertussis) 		PF00583
(Acetyltransf_1) 		4 THR A  65
LEU A  63
VAL A  69
LEU A 106
 None
 0.87A 1mz9D-3d3sA:
undetectable		 1mz9D-3d3sA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doc GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Brucella
abortus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 154
LEU A 158
VAL A 161
LEU A 165
 None
 0.95A 1mz9D-3docA:
undetectable		 1mz9D-3docA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 THR A 147
LEU A 151
VAL A 154
LEU A 158
 None
 0.57A 1mz9D-3e97A:
undetectable		 1mz9D-3e97A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6p TRANSCRIPTIONAL
REGULATORY PROTEIN
YYCF

(Bacillus
subtilis) 		PF00072
(Response_reg) 		4 THR A 106
LEU A 110
VAL A 113
LEU A 117
 None
 0.80A 1mz9D-3f6pA:
undetectable		 1mz9D-3f6pA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj1 PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Ruegeria
pomeroyi) 		PF01380
(SIS) 		4 THR A 185
LEU A 182
VAL A  19
LEU A  22
 None
 0.98A 1mz9D-3fj1A:
undetectable		 1mz9D-3fj1A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kol GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE

(Nostoc
punctiforme) 		PF00903
(Glyoxalase) 		4 THR A  54
LEU A  55
VAL A  64
LEU A  77
 None
 0.99A 1mz9D-3kolA:
undetectable		 1mz9D-3kolA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksd GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
1

(Staphylococcus
aureus) 		no annotation 4 THR Q 152
LEU Q 156
VAL Q 159
LEU Q 163
 None
 0.96A 1mz9D-3ksdQ:
undetectable		 1mz9D-3ksdQ:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx6 FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Babesia bovis) 		PF00274
(Glycolytic) 		4 THR A 204
LEU A 208
VAL A 211
LEU A 215
 None
 0.67A 1mz9D-3kx6A:
undetectable		 1mz9D-3kx6A:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnk UREIDOGLYCINE-GLYOXY
LATE
AMINOTRANSFERASE

(Klebsiella
pneumoniae) 		PF00266
(Aminotran_5) 		4 THR A 379
LEU A 383
VAL A 386
LEU A 390
 None
 0.92A 1mz9D-3nnkA:
undetectable		 1mz9D-3nnkA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvl 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Trypanosoma
brucei) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 THR A 435
LEU A 439
VAL A 442
LEU A 446
 None
 0.62A 1mz9D-3nvlA:
undetectable		 1mz9D-3nvlA:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3odw RHO GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 1

(Homo sapiens) 		PF00621
(RhoGEF) 		4 THR A 655
LEU A 654
VAL A 668
LEU A 670
 None
 0.96A 1mz9D-3odwA:
undetectable		 1mz9D-3odwA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		4 THR A 289
LEU A 293
VAL A 296
LEU A 300
 None
 0.63A 1mz9D-3pjxA:
undetectable		 1mz9D-3pjxA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6k ACETYLGLUTAMATE
KINASE

(Xanthomonas
campestris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		4 THR A 272
LEU A 213
VAL A  52
LEU A  53
 None
 0.94A 1mz9D-3s6kA:
undetectable		 1mz9D-3s6kA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sho TRANSCRIPTIONAL
REGULATOR, RPIR
FAMILY

(Sphaerobacter
thermophilus) 		PF01380
(SIS) 		4 THR A 235
LEU A 247
VAL A 250
LEU A 254
 None
 0.81A 1mz9D-3shoA:
undetectable		 1mz9D-3shoA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 THR A 905
LEU A 908
VAL A 891
LEU A 888
 None
 0.95A 1mz9D-3thzA:
undetectable		 1mz9D-3thzA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un1 PROBABLE
OXIDOREDUCTASE

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		4 THR A 149
LEU A 153
VAL A 156
LEU A 160
 None
 0.97A 1mz9D-3un1A:
undetectable		 1mz9D-3un1A:
11.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v2p CARTILAGE
OLIGOMERIZATION
MATRIX PROTEIN
(COILED-COIL DOMAIN)

(Mus musculus) 		PF11598
(COMP) 		4 THR A  40
LEU A  44
VAL A  47
LEU A  51
 STE  A   1 (-4.0A)
STE  A   1 ( 4.5A)
None
STE  A   1 (-4.4A)
 0.39A 1mz9D-3v2pA:
5.7		 1mz9D-3v2pA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wc3 ENDO-1,
4-BETA-GLUCANASE

(Eisenia fetida) 		PF00759
(Glyco_hydro_9) 		4 THR A 288
LEU A 291
VAL A 294
LEU A 298
 GOL  A 506 (-4.7A)
GOL  A 506 ( 4.4A)
None
None
 0.96A 1mz9D-3wc3A:
undetectable		 1mz9D-3wc3A:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 THR A 184
LEU A 188
VAL A 191
LEU A 195
 None
 0.56A 1mz9D-3zgxA:
1.7		 1mz9D-3zgxA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4u BIFUNCTIONAL PROTEIN
FOLD

(Acinetobacter
baumannii) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 THR A  29
LEU A  25
VAL A  22
LEU A  18
 None
 0.98A 1mz9D-4b4uA:
undetectable		 1mz9D-4b4uA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8b GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF16417
(CNOT1_TTP_bind)
PF16418
(CNOT1_HEAT)
PF16419
(CNOT1_HEAT_N) 		4 THR A 465
LEU A 462
VAL A 471
LEU A 475
 None
 0.96A 1mz9D-4b8bA:
undetectable		 1mz9D-4b8bA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Toxoplasma
gondii) 		PF00274
(Glycolytic) 		4 THR A 277
LEU A 281
VAL A 284
LEU A 288
 None
 0.71A 1mz9D-4d2jA:
undetectable		 1mz9D-4d2jA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dib GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Bacillus
anthracis) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR A 152
LEU A 156
VAL A 159
LEU A 163
 None
 0.80A 1mz9D-4dibA:
undetectable		 1mz9D-4dibA:
8.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpd APO-D-GLYCERALDEHYDE
-3-PHOSPHATE
DEHYDROGENASE

(Homarus
americanus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 THR 1 149
LEU 1 153
VAL 1 156
LEU 1 160
 None
 0.96A 1mz9D-4gpd1:
undetectable		 1mz9D-4gpd1:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxb SORTING NEXIN-17

(Homo sapiens) 		no annotation 4 THR A 139
LEU A 143
VAL A 146
LEU A 150
 None
 0.80A 1mz9D-4gxbA:
undetectable		 1mz9D-4gxbA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h19 MANDELATE RACEMASE

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 103
LEU A 107
VAL A 110
LEU A 114
 CL  A 403 (-3.1A)
None
None
None
 0.96A 1mz9D-4h19A:
undetectable		 1mz9D-4h19A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hkg PHOSPHOPANTETHEINE
ATTACHMENT SITE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF00550
(PP-binding) 		4 THR A  34
LEU A  38
VAL A  16
LEU A  15
 MRD  A 100 (-4.2A)
None
None
None
 0.85A 1mz9D-4hkgA:
undetectable		 1mz9D-4hkgA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hpm BCL-6
COREPRESSOR-LIKE
PROTEIN 1

(Homo sapiens) 		PF16553
(PUFD) 		4 THR A1667
LEU A1666
VAL A1660
LEU A1611
 None
 0.99A 1mz9D-4hpmA:
undetectable		 1mz9D-4hpmA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9a PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.1393C

(Streptococcus
mutans) 		no annotation 4 THR A 258
LEU A 262
VAL A 265
LEU A 269
 None
 0.67A 1mz9D-4l9aA:
undetectable		 1mz9D-4l9aA:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxi MCP HYDROLASE

(Sphingomonas
wittichii) 		PF12697
(Abhydrolase_6) 		4 THR A  84
LEU A  87
VAL A  31
LEU A  30
 None
 0.92A 1mz9D-4lxiA:
undetectable		 1mz9D-4lxiA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot9 NUCLEAR FACTOR
NF-KAPPA-B P100
SUBUNIT

(Homo sapiens) 		PF12796
(Ank_2) 		4 THR A 684
LEU A 687
VAL A 650
LEU A 653
 None
 0.93A 1mz9D-4ot9A:
undetectable		 1mz9D-4ot9A:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oy4 CHIMERA PROTEIN OF
CALMODULIN, GPF-LIKE
PROTEIN EOSFP, AND
MYOSIN LIGHT CHAIN
KINASE

(Gallus gallus;
Lobophyllia
hemprichii;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 THR A  28
LEU A  31
VAL A  34
LEU A  38
 None
 0.84A 1mz9D-4oy4A:
undetectable		 1mz9D-4oy4A:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F

(Vibrio cholerae) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 THR F  12
LEU F  16
VAL F  19
LEU F  23
 None
 0.91A 1mz9D-4p6vF:
undetectable		 1mz9D-4p6vF:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq0 FACT COMPLEX SUBUNIT
POB3

(Saccharomyces
cerevisiae) 		PF08512
(Rtt106) 		4 THR A 353
LEU A 357
VAL A 360
LEU A 364
 None
 0.97A 1mz9D-4pq0A:
undetectable		 1mz9D-4pq0A:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxj C-JUN-AMINO-TERMINAL
KINASE-INTERACTING
PROTEIN 3

(Homo sapiens) 		PF16471
(JIP_LZII) 		4 THR A 433
LEU A 437
VAL A 440
LEU A 444
 None
 0.80A 1mz9D-4pxjA:
4.7		 1mz9D-4pxjA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		4 THR A 463
LEU A 467
VAL A 470
LEU A 474
 None
 0.71A 1mz9D-4q65A:
undetectable		 1mz9D-4q65A:
7.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r94 NON-STRUCTURAL
PROTEIN NS1

(Rodent
protoparvovirus
1) 		PF12433
(PV_NSP1) 		4 THR A 166
LEU A 165
VAL A 158
LEU A 157
 None
 0.94A 1mz9D-4r94A:
undetectable		 1mz9D-4r94A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 THR A2381
LEU A2384
VAL A2348
LEU A2351
 None
 0.95A 1mz9D-4rlvA:
undetectable		 1mz9D-4rlvA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		4 THR A 235
LEU A 239
VAL A 242
LEU A 246
 None
None
HEM  A 501 ( 4.1A)
HEM  A 501 ( 4.8A)
 0.67A 1mz9D-4tpnA:
undetectable		 1mz9D-4tpnA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		4 THR L 162
LEU L 167
VAL L 170
LEU L 174
 None
None
MPD  S2008 ( 4.4A)
None
 0.78A 1mz9D-4u9iL:
undetectable		 1mz9D-4u9iL:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uis GAMMA-SECRETASE

(Homo sapiens) 		PF05450
(Nicastrin) 		4 THR A 483
LEU A 487
VAL A 490
LEU A 494
 None
 0.74A 1mz9D-4uisA:
undetectable		 1mz9D-4uisA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 THR A 276
LEU A 280
VAL A 283
LEU A 287
 None
 0.75A 1mz9D-4upkA:
undetectable		 1mz9D-4upkA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 THR A 321
LEU A 318
VAL A 203
LEU A 202
 None
 0.97A 1mz9D-4utgA:
undetectable		 1mz9D-4utgA:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbd BSHC

(Bacillus
subtilis) 		PF10079
(BshC) 		4 THR A 193
LEU A 197
VAL A 200
LEU A 204
 None
 0.59A 1mz9D-4wbdA:
undetectable		 1mz9D-4wbdA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr9 CALS8

(Micromonospora
echinospora) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 THR A  47
LEU A  51
VAL A  67
LEU A  70
 NAD  A 501 ( 4.5A)
None
None
None
 0.85A 1mz9D-4xr9A:
undetectable		 1mz9D-4xr9A:
7.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta) 		PF01036
(Bac_rhodopsin) 		4 THR A 216
LEU A 217
VAL A 246
LEU A 245
 LFA  A 330 (-3.6A)
LFA  A 330 ( 4.8A)
None
None
 0.90A 1mz9D-4xtlA:
undetectable		 1mz9D-4xtlA:
10.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 THR A  58
LEU A  54
VAL A  51
LEU A  47
 None
 0.93A 1mz9D-4y21A:
undetectable		 1mz9D-4y21A:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z2a FURIN

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 THR A 340
LEU A 429
VAL A 397
LEU A 396
 None
 0.95A 1mz9D-4z2aA:
undetectable		 1mz9D-4z2aA:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7d LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Vibrio
vulnificus) 		PF03466
(LysR_substrate) 		4 THR A 289
LEU A 293
VAL A 296
LEU A 300
 None
 0.78A 1mz9D-5b7dA:
undetectable		 1mz9D-5b7dA:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 THR A 156
LEU A 160
VAL A 163
LEU A 167
 None
 0.73A 1mz9D-5c65A:
undetectable		 1mz9D-5c65A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck3 PUTATIVE SIGNAL
RECOGNITION PARTICLE
PROTEIN

(Chaetomium
thermophilum) 		PF09439
(SRPRB) 		4 THR B 216
LEU B 220
VAL B 223
LEU B 227
 None
 0.90A 1mz9D-5ck3B:
undetectable		 1mz9D-5ck3B:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqs ELONGATOR COMPLEX
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF04762
(IKI3) 		4 THR A1269
LEU A1266
VAL A1299
LEU A1302
 None
 0.94A 1mz9D-5cqsA:
undetectable		 1mz9D-5cqsA:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.94A 1mz9D-5cs4A:
undetectable		 1mz9D-5cs4A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.97A 1mz9D-5csaA:
undetectable		 1mz9D-5csaA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.88A 1mz9D-5cslA:
undetectable		 1mz9D-5cslA:
2.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzt CYLM

(Enterococcus
faecalis) 		PF05147
(LANC_like)
PF13575
(DUF4135) 		4 THR A 218
LEU A 222
VAL A 225
LEU A 229
 None
 0.60A 1mz9D-5dztA:
undetectable		 1mz9D-5dztA:
4.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ee5 BREFELDIN
A-INHIBITED GUANINE
NUCLEOTIDE-EXCHANGE
PROTEIN 1

(Homo sapiens) 		PF16213
(DCB) 		4 THR A 199
LEU A 202
VAL A 175
LEU A 172
 ALY  A 195 ( 3.5A)
CL  A 308 (-4.0A)
None
None
 0.91A 1mz9D-5ee5A:
undetectable		 1mz9D-5ee5A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 THR A 158
LEU A 162
VAL A 165
LEU A 169
 None
 0.80A 1mz9D-5eqiA:
undetectable		 1mz9D-5eqiA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		4 THR A  95
LEU A  37
VAL A  28
LEU A  27
 None
 0.89A 1mz9D-5f8eA:
undetectable		 1mz9D-5f8eA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		4 THR A 483
LEU A 487
VAL A 490
LEU A 494
 None
 0.73A 1mz9D-5fn4A:
undetectable		 1mz9D-5fn4A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd DNA DAMAGE-BINDING
PROTEIN 1

(Homo sapiens) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 THR A1125
LEU A1129
VAL A1132
LEU A1136
 None
 0.94A 1mz9D-5fqdA:
undetectable		 1mz9D-5fqdA:
5.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3w FIBRONECTIN/FIBRINOG
EN BINDING PROTEIN

(Streptococcus
suis) 		PF05670
(DUF814)
PF05833
(FbpA) 		4 THR A 117
LEU A 121
VAL A 124
LEU A 128
 None
 0.66A 1mz9D-5h3wA:
2.8		 1mz9D-5h3wA:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h67 CHROMOSOME PARTITION
PROTEIN SMC

(Bacillus
subtilis) 		PF02463
(SMC_N) 		4 THR A 184
LEU A 188
VAL A 191
LEU A 195
 None
 0.94A 1mz9D-5h67A:
1.9		 1mz9D-5h67A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 THR A 386
LEU A 363
VAL A 362
LEU A 343
 None
 0.88A 1mz9D-5i51A:
undetectable		 1mz9D-5i51A:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6e ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 THR A1229
LEU A1183
VAL A1186
LEU A1190
 None
 0.94A 1mz9D-5i6eA:
undetectable		 1mz9D-5i6eA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0e XYLOSE ISOMERASE

(Thermotoga
neapolitana) 		PF01261
(AP_endonuc_2) 		3 THR A 114
LEU A 118
VAL A 121
 None
 0.36A 1mz9E-1a0eA:
undetectable		 1mz9E-1a0eA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		3 THR A 212
LEU A 216
VAL A 219
 None
 0.65A 1mz9E-1a5cA:
undetectable		 1mz9E-1a5cA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ao0 GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran)
PF13522
(GATase_6) 		3 THR A 412
LEU A 413
VAL A 401
 None
 0.64A 1mz9E-1ao0A:
0.0		 1mz9E-1ao0A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b4p PROTEIN (GLUTATHIONE
S-TRANSFERASE)

(Rattus
norvegicus) 		PF00043
(GST_C)
PF02798
(GST_N) 		3 THR A 106
LEU A 110
VAL A 113
 None
 0.47A 1mz9E-1b4pA:
undetectable		 1mz9E-1b4pA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bct BACTERIORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		3 THR A 170
LEU A 174
VAL A 177
 None
 0.54A 1mz9E-1bctA:
1.8		 1mz9E-1bctA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg8 PROTEIN (HEMOGLOBIN)

(Dasyatis akajei) 		PF00042
(Globin) 		3 THR B  24
LEU B  28
VAL B  31
 None
 0.67A 1mz9E-1cg8B:
undetectable		 1mz9E-1cg8B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cwp COAT PROTEIN

(Cowpea
chlorotic
mottle virus) 		PF01318
(Bromo_coat) 		3 THR A 146
LEU A  86
VAL A 178
 None
 0.68A 1mz9E-1cwpA:
undetectable		 1mz9E-1cwpA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6s O-ACETYLSERINE
SULFHYDRYLASE

(Salmonella
enterica) 		PF00291
(PALP) 		3 THR A  72
LEU A  76
VAL A  79
 MET  A 401 (-3.8A)
None
None
 0.65A 1mz9E-1d6sA:
undetectable		 1mz9E-1d6sA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcn DELTA 2 CRYSTALLIN

(Anas
platyrhynchos) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 373
LEU A 377
VAL A 380
 None
 0.66A 1mz9E-1dcnA:
0.3		 1mz9E-1dcnA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxz ACETYLCHOLINE
RECEPTOR PROTEIN,
ALPHA CHAIN

(Tetronarce
californica) 		PF02932
(Neur_chan_memb) 		3 THR A 254
LEU A 258
VAL A 261
 None
 0.34A 1mz9E-1dxzA:
2.8		 1mz9E-1dxzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e12 HALORHODOPSIN

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		3 THR A 198
LEU A 202
VAL A 205
 None
 0.58A 1mz9E-1e12A:
undetectable		 1mz9E-1e12A:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ei5 D-AMINOPEPTIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase)
PF07930
(DAP_B) 		3 THR A  68
LEU A  72
VAL A  76
 None
 0.52A 1mz9E-1ei5A:
undetectable		 1mz9E-1ei5A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		3 THR A1205
LEU A1209
VAL A1212
 None
 0.67A 1mz9E-1fdjA:
undetectable		 1mz9E-1fdjA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs5 GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE

(Escherichia
coli) 		PF01182
(Glucosamine_iso) 		3 THR A   8
LEU A   6
VAL A 238
 None
 0.66A 1mz9E-1fs5A:
undetectable		 1mz9E-1fs5A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw8 PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 THR A 278
LEU A 282
VAL A 285
 None
 0.21A 1mz9E-1fw8A:
undetectable		 1mz9E-1fw8A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gq1 CYTOCHROME CD1
NITRITE REDUCTASE

(Paracoccus
pantotrophus) 		PF02239
(Cytochrom_D1)
PF13442
(Cytochrome_CBB3) 		3 THR A 335
LEU A 323
VAL A 314
 None
 0.64A 1mz9E-1gq1A:
undetectable		 1mz9E-1gq1A:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		3 THR A 371
LEU A 375
VAL A 378
 None
 0.62A 1mz9E-1i0aA:
undetectable		 1mz9E-1i0aA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1icp 12-OXOPHYTODIENOATE
REDUCTASE 1

(Solanum
lycopersicum) 		PF00724
(Oxidored_FMN) 		3 THR A 255
LEU A 259
VAL A 262
 None
 0.59A 1mz9E-1icpA:
undetectable		 1mz9E-1icpA:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		3 THR A 185
LEU A 189
VAL A 192
 None
 0.43A 1mz9E-1jdzA:
undetectable		 1mz9E-1jdzA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		3 THR A 135
LEU A 139
VAL A 142
 None
 0.55A 1mz9E-1kczA:
undetectable		 1mz9E-1kczA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpl PUTATIVE CLC FAMILY,
CHLORINE TRANSPORT
PROTEIN

(Salmonella
enterica) 		PF00654
(Voltage_CLC) 		3 THR A 180
LEU A 177
VAL A 162
 None
 0.61A 1mz9E-1kplA:
undetectable		 1mz9E-1kplA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6n GAG POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00540
(Gag_p17)
PF00607
(Gag_p24) 		3 THR A  81
LEU A  85
VAL A  88
 None
 0.61A 1mz9E-1l6nA:
undetectable		 1mz9E-1l6nA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nmo HYPOTHETICAL PROTEIN
YBGI

(Escherichia
coli) 		PF01784
(NIF3) 		3 THR A 134
LEU A 133
VAL A 137
 None
 0.49A 1mz9E-1nmoA:
undetectable		 1mz9E-1nmoA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nrj SIGNAL RECOGNITION
PARTICLE RECEPTOR
ALPHA SUBUNIT
HOMOLOG

(Saccharomyces
cerevisiae) 		PF09201
(SRX) 		3 THR A 102
LEU A 106
VAL A 109
 None
 0.53A 1mz9E-1nrjA:
undetectable		 1mz9E-1nrjA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nww LIMONENE-1,2-EPOXIDE
HYDROLASE

(Rhodococcus
erythropolis) 		PF07858
(LEH) 		3 THR A  70
LEU A  74
VAL A  77
 None
HPN  A 900 ( 4.8A)
None
 0.47A 1mz9E-1nwwA:
undetectable		 1mz9E-1nwwA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		3 THR A 274
LEU A 278
VAL A 281
 None
 0.63A 1mz9E-1o2dA:
undetectable		 1mz9E-1o2dA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1orr CDP-TYVELOSE-2-EPIME
RASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		3 THR A 104
LEU A 108
VAL A 111
 None
 0.68A 1mz9E-1orrA:
undetectable		 1mz9E-1orrA:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ox3 FIBRITIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 THR A  48
LEU A  52
VAL A  55
 None
 0.28A 1mz9E-1ox3A:
2.9		 1mz9E-1ox3A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		3 THR A 450
LEU A 451
VAL A 481
 None
ADP  A1528 (-4.2A)
ADP  A1528 (-3.8A)
 0.66A 1mz9E-1q3sA:
undetectable		 1mz9E-1q3sA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q3s THERMOSOME ALPHA
SUBUNIT

(Thermococcus
sp. JCM 11816) 		PF00118
(Cpn60_TCP1) 		3 THR A 459
LEU A 463
VAL A 466
 None
 0.39A 1mz9E-1q3sA:
undetectable		 1mz9E-1q3sA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q51 MENB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 THR A  65
LEU A  69
VAL A  72
 None
 0.38A 1mz9E-1q51A:
undetectable		 1mz9E-1q51A:
10.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 THR A  39
LEU A  76
VAL A  75
 None
 0.63A 1mz9E-1q5aA:
undetectable		 1mz9E-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qh1 PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 THR B 321
LEU B 325
VAL B 328
 None
 0.67A 1mz9E-1qh1B:
undetectable		 1mz9E-1qh1B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpg 3-PHOSPHOGLYCERATE
KINASE

(Saccharomyces
cerevisiae) 		PF00162
(PGK) 		3 THR A 349
LEU A 353
VAL A 356
 None
 0.28A 1mz9E-1qpgA:
undetectable		 1mz9E-1qpgA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		3 THR A  97
LEU A 101
VAL A 104
 PLP  A1227 (-3.8A)
None
None
 0.43A 1mz9E-1qz9A:
undetectable		 1mz9E-1qz9A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4n AMYLOID BETA
PRECURSOR
PROTEIN-BINDING
PROTEIN 1

(Homo sapiens) 		PF00899
(ThiF) 		3 THR A 135
LEU A 139
VAL A 142
 None
 0.22A 1mz9E-1r4nA:
undetectable		 1mz9E-1r4nA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r55 ADAM 33

(Homo sapiens) 		PF01421
(Reprolysin) 		3 THR A 233
LEU A 237
VAL A 240
 None
 0.66A 1mz9E-1r55A:
undetectable		 1mz9E-1r55A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		3 THR A 278
LEU A 282
VAL A 285
 None
 0.35A 1mz9E-1rtrA:
undetectable		 1mz9E-1rtrA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sj5 CONSERVED
HYPOTHETICAL PROTEIN
TM0160

(Thermotoga
maritima) 		PF02577
(DNase-RNase) 		3 THR A  57
LEU A  61
VAL A  64
 None
 0.49A 1mz9E-1sj5A:
undetectable		 1mz9E-1sj5A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		3 THR A  76
LEU A  80
VAL A  83
 None
 0.24A 1mz9E-1sqgA:
undetectable		 1mz9E-1sqgA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sr2 PUTATIVE SENSOR-LIKE
HISTIDINE KINASE
YOJN

(Escherichia
coli) 		PF01627
(Hpt) 		3 THR A 840
LEU A 844
VAL A 847
 None
 0.60A 1mz9E-1sr2A:
undetectable		 1mz9E-1sr2A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szi MANNOSE-6-PHOSPHATE
RECEPTOR BINDING
PROTEIN 1

(Mus musculus) 		PF03036
(Perilipin) 		3 THR A 272
LEU A 276
VAL A 279
 None
 0.61A 1mz9E-1sziA:
2.1		 1mz9E-1sziA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t35 HYPOTHETICAL PROTEIN
YVDD, PUTATIVE
LYSINE DECARBOXYLASE

(Bacillus
subtilis) 		PF03641
(Lysine_decarbox) 		3 THR A 110
LEU A 114
VAL A 117
 SO4  A 192 (-3.6A)
None
None
 0.32A 1mz9E-1t35A:
undetectable		 1mz9E-1t35A:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t5e MULTIDRUG RESISTANCE
PROTEIN MEXA

(Pseudomonas
aeruginosa) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		3 THR A  29
LEU A 259
VAL A 206
 None
 0.61A 1mz9E-1t5eA:
undetectable		 1mz9E-1t5eA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tis THYMIDYLATE SYNTHASE

(Escherichia
virus T4) 		PF00303
(Thymidylat_synt) 		3 THR A 254
LEU A 258
VAL A 261
 None
 0.49A 1mz9E-1tisA:
undetectable		 1mz9E-1tisA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2m HISTONE-LIKE PROTEIN
HLP-1

(Escherichia
coli) 		PF03938
(OmpH) 		3 THR A 153
LEU A 157
VAL A 160
 None
 0.31A 1mz9E-1u2mA:
1.2		 1mz9E-1u2mA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		3 THR A 179
LEU A 183
VAL A 186
 None
 0.49A 1mz9E-1uazA:
undetectable		 1mz9E-1uazA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 THR A  35
LEU A  39
VAL A  42
 None
 0.45A 1mz9E-1ufaA:
undetectable		 1mz9E-1ufaA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uiy ENOYL-COA HYDRATASE

(Thermus
thermophilus) 		PF00378
(ECH_1) 		3 THR A  97
LEU A  49
VAL A  12
 None
 0.36A 1mz9E-1uiyA:
undetectable		 1mz9E-1uiyA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		3 THR A 285
LEU A 284
VAL A 278
 None
 0.60A 1mz9E-1vg0A:
undetectable		 1mz9E-1vg0A:
4.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		3 THR A 457
LEU A 461
VAL A 464
 None
 0.30A 1mz9E-1w6jA:
undetectable		 1mz9E-1w6jA:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w9x ALPHA AMYLASE

(Bacillus
halmapalus) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 THR A 246
LEU A 250
VAL A 253
 None
 0.49A 1mz9E-1w9xA:
undetectable		 1mz9E-1w9xA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wac P2 PROTEIN

(Pseudomonas
virus phi6) 		PF00680
(RdRP_1) 		3 THR A 652
LEU A 656
VAL A 659
 None
 0.54A 1mz9E-1wacA:
undetectable		 1mz9E-1wacA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wek HYPOTHETICAL PROTEIN
TT1465

(Thermus
thermophilus) 		PF03641
(Lysine_decarbox) 		3 THR A 144
LEU A 148
VAL A 151
 PO4  A 501 (-3.9A)
None
None
 0.38A 1mz9E-1wekA:
undetectable		 1mz9E-1wekA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiw GLUCOSE-6-PHOSPHATE
ISOMERASE LIKE
PROTEIN

(Thermus
thermophilus) 		PF10432
(bact-PGI_C) 		3 THR A 122
LEU A 119
VAL A 127
 None
 0.66A 1mz9E-1wiwA:
undetectable		 1mz9E-1wiwA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkp FLOWERING LOCUS T
PROTEIN

(Arabidopsis
thaliana) 		PF01161
(PBP) 		3 THR A  27
LEU A  28
VAL A 160
 SO4  A1001 (-3.6A)
None
None
 0.62A 1mz9E-1wkpA:
undetectable		 1mz9E-1wkpA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wps HUT OPERON POSITIVE
REGULATORY PROTEIN

(Bacillus
subtilis) 		PF09021
(HutP) 		3 THR A  79
LEU A  83
VAL A  86
 None
 0.46A 1mz9E-1wpsA:
undetectable		 1mz9E-1wpsA:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwk PHOSPHOGLYCERATE
DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 THR A 268
LEU A 267
VAL A 240
 None
 0.68A 1mz9E-1wwkA:
undetectable		 1mz9E-1wwkA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wz9 MASPIN PRECURSOR

(Homo sapiens) 		PF00079
(Serpin) 		3 THR A  37
LEU A  41
VAL A  44
 None
 0.48A 1mz9E-1wz9A:
undetectable		 1mz9E-1wz9A:
9.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1s RAS-RELATED PROTEIN
M-RAS

(Mus musculus) 		PF00071
(Ras) 		3 THR A 167
LEU A 171
VAL A 174
 None
 0.36A 1mz9E-1x1sA:
undetectable		 1mz9E-1x1sA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkd ISOCITRATE
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00180
(Iso_dh) 		3 THR A 226
LEU A 280
VAL A 261
 None
 0.62A 1mz9E-1xkdA:
undetectable		 1mz9E-1xkdA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y11 HYPOTHETICAL PROTEIN
RV1264/MT1302

(Mycobacterium
tuberculosis) 		PF00211
(Guanylate_cyc)
PF16701
(Ad_Cy_reg) 		3 THR A 280
LEU A 284
VAL A 287
 None
 0.15A 1mz9E-1y11A:
undetectable		 1mz9E-1y11A:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y9u PUTATIVE IRON
BINDING PROTEIN

(Bordetella
pertussis) 		PF13343
(SBP_bac_6) 		3 THR A 160
LEU A 164
VAL A 167
 None
 0.62A 1mz9E-1y9uA:
undetectable		 1mz9E-1y9uA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yht DSPB

(Aggregatibacter
actinomycetemcomitans) 		PF00728
(Glyco_hydro_20) 		3 THR A 346
LEU A 350
VAL A 353
 None
 0.27A 1mz9E-1yhtA:
undetectable		 1mz9E-1yhtA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yul PROBABLE
NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF01467
(CTP_transf_like) 		3 THR A  85
LEU A  89
VAL A  92
 None
 0.35A 1mz9E-1yulA:
undetectable		 1mz9E-1yulA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		3 THR A 513
LEU A 517
VAL A 520
 None
 0.40A 1mz9E-1z7eA:
undetectable		 1mz9E-1z7eA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbd RABPHILIN-3A

(Rattus
norvegicus) 		PF00071
(Ras) 		3 THR A 175
LEU A 179
VAL A 182
 None
 0.30A 1mz9E-1zbdA:
undetectable		 1mz9E-1zbdA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zc6 PROBABLE
N-ACETYLGLUCOSAMINE
KINASE

(Chromobacterium
violaceum) 		PF01869
(BcrAD_BadFG) 		3 THR A 185
LEU A 189
VAL A 192
 None
 0.49A 1mz9E-1zc6A:
undetectable		 1mz9E-1zc6A:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		3 THR A 457
LEU A 461
VAL A 464
 None
 0.59A 1mz9E-1zrzA:
undetectable		 1mz9E-1zrzA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zwt MAJOR STRUCTURAL
SUBUNIT OF
BUNDLE-FORMING PILUS

(Escherichia
coli) 		PF05307
(Bundlin) 		3 THR A  41
LEU A  38
VAL A  71
 None
 0.65A 1mz9E-1zwtA:
undetectable		 1mz9E-1zwtA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy9 ALPHA-GALACTOSIDASE

(Thermotoga
maritima) 		PF02065
(Melibiase) 		3 THR A  51
LEU A 132
VAL A 127
 None
 0.64A 1mz9E-1zy9A:
undetectable		 1mz9E-1zy9A:
5.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a33 HYPOTHETICAL PROTEIN

(Arabidopsis
thaliana) 		PF03641
(Lysine_decarbox) 		3 THR A 122
LEU A 126
VAL A 129
 SO4  A 600 (-3.6A)
None
None
 0.45A 1mz9E-2a33A:
undetectable		 1mz9E-2a33A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2afh NITROGENASE
MOLYBDENUM-IRON
PROTEIN

(Azotobacter
vinelandii) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		3 THR B 325
LEU B 329
VAL B 332
 None
 0.66A 1mz9E-2afhB:
undetectable		 1mz9E-2afhB:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aml SIS DOMAIN PROTEIN

(Listeria
monocytogenes) 		PF01380
(SIS) 		3 THR A 101
LEU A 105
VAL A 108
 None
 0.64A 1mz9E-2amlA:
undetectable		 1mz9E-2amlA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b3o TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 6

(Homo sapiens) 		PF00017
(SH2)
PF00102
(Y_phosphatase) 		3 THR A 132
LEU A 150
VAL A 164
 None
 0.64A 1mz9E-2b3oA:
undetectable		 1mz9E-2b3oA:
7.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b8n GLYCERATE KINASE,
PUTATIVE

(Thermotoga
maritima) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 THR A 101
LEU A 105
VAL A 108
 None
 0.61A 1mz9E-2b8nA:
undetectable		 1mz9E-2b8nA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi0 HYPOTHETICAL PROTEIN
RV0216

(Mycobacterium
tuberculosis) 		no annotation 3 THR A 270
LEU A 335
VAL A 306
 None
 0.46A 1mz9E-2bi0A:
undetectable		 1mz9E-2bi0A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1h DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Prosthecochloris
vibrioformis) 		PF00490
(ALAD) 		3 THR A 187
LEU A 184
VAL A 192
 None
 0.64A 1mz9E-2c1hA:
undetectable		 1mz9E-2c1hA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		3 THR A 332
LEU A 329
VAL A 284
 None
 0.60A 1mz9E-2c5aA:
undetectable		 1mz9E-2c5aA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		3 THR A 179
LEU A 244
VAL A 208
 None
 0.58A 1mz9E-2cbfA:
undetectable		 1mz9E-2cbfA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cs0 HEMATOPOIETIC SH2
DOMAIN CONTAINING

(Homo sapiens) 		PF00017
(SH2) 		3 THR A 106
LEU A 105
VAL A  90
 None
 0.66A 1mz9E-2cs0A:
undetectable		 1mz9E-2cs0A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuk GLYCERATE
DEHYDROGENASE/GLYOXY
LATE REDUCTASE

(Thermus
thermophilus) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		3 THR A 106
LEU A 110
VAL A 113
 None
 0.60A 1mz9E-2cukA:
undetectable		 1mz9E-2cukA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2i GLYCERALDEHYDE
3-PHOSPHATE
DEHYDROGENASE

(Synechococcus
sp.) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		3 THR A 156
LEU A 160
VAL A 163
 SO4  A1339 ( 4.3A)
None
None
 0.64A 1mz9E-2d2iA:
undetectable		 1mz9E-2d2iA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		3 THR A 255
LEU A 259
VAL A 262
 None
 0.46A 1mz9E-2d5wA:
undetectable		 1mz9E-2d5wA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2die AMYLASE

(Bacillus sp.
(in: Bacteria)) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		3 THR A 246
LEU A 250
VAL A 253
 None
 0.36A 1mz9E-2dieA:
undetectable		 1mz9E-2dieA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		3 THR A 127
LEU A 128
VAL A 134
 None
 0.59A 1mz9E-2dwcA:
undetectable		 1mz9E-2dwcA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2a PROTEIN (ENZYME IIA)

(Lactococcus
lactis) 		PF02255
(PTS_IIA) 		3 THR A  85
LEU A  89
VAL A  92
 None
 0.53A 1mz9E-2e2aA:
1.9		 1mz9E-2e2aA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea1 RIBONUCLEASE I

(Escherichia
coli) 		PF00445
(Ribonuclease_T2) 		3 THR A 108
LEU A 112
VAL A 115
 None
 0.55A 1mz9E-2ea1A:
undetectable		 1mz9E-2ea1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2egu CYSTEINE SYNTHASE

(Geobacillus
kaustophilus) 		PF00291
(PALP) 		3 THR A  76
LEU A  80
VAL A  83
 None
 0.63A 1mz9E-2eguA:
undetectable		 1mz9E-2eguA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eo4 150AA LONG
HYPOTHETICAL
HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN

(Sulfurisphaera
tokodaii) 		PF01230
(HIT) 		3 THR A  54
LEU A  58
VAL A  61
 None
 0.26A 1mz9E-2eo4A:
undetectable		 1mz9E-2eo4A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdm LEGHEMOGLOBIN (OXY)

(Lupinus luteus) 		PF00042
(Globin) 		3 THR A  89
LEU A  93
VAL A  96
 None
HEM  A 154 (-4.6A)
None
 0.53A 1mz9E-2gdmA:
undetectable		 1mz9E-2gdmA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gnx HYPOTHETICAL PROTEIN

(Mus musculus) 		PF09404
(DUF2003) 		3 THR A 403
LEU A 395
VAL A 382
 None
 0.65A 1mz9E-2gnxA:
undetectable		 1mz9E-2gnxA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 THR A 168
LEU A 172
VAL A 175
 None
 0.68A 1mz9E-2gz3A:
undetectable		 1mz9E-2gz3A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5x HOLLIDAY JUNCTION
ATP-DEPENDENT DNA
HELICASE RUVA

(Mycobacterium
tuberculosis) 		PF01330
(RuvA_N)
PF07499
(RuvA_C)
PF14520
(HHH_5) 		3 THR A  73
LEU A  74
VAL A  80
 None
None
GOL  A 501 ( 4.8A)
 0.68A 1mz9E-2h5xA:
undetectable		 1mz9E-2h5xA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		3 THR A  19
LEU A  23
VAL A  26
 None
 0.56A 1mz9E-2hg4A:
undetectable		 1mz9E-2hg4A:
3.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		3 THR A 108
LEU A 112
VAL A 115
 None
 0.60A 1mz9E-2horA:
undetectable		 1mz9E-2horA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i34 ACID PHOSPHATASE

(Bacillus
anthracis) 		PF03767
(Acid_phosphat_B) 		3 THR A 134
LEU A 138
VAL A 141
 None
 0.66A 1mz9E-2i34A:
undetectable		 1mz9E-2i34A:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibl FIBRITIN

(Enterobacteria
phage Ox2;
Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 THR A  48
LEU A  52
VAL A  55
 None
 0.31A 1mz9E-2iblA:
3.0		 1mz9E-2iblA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		3 THR A 289
LEU A 293
VAL A 296
 None
 0.68A 1mz9E-2icsA:
undetectable		 1mz9E-2icsA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 THR A 420
LEU A 424
VAL A 427
 None
 0.43A 1mz9E-2ifyA:
undetectable		 1mz9E-2ifyA:
7.00