SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_A_VDYA1002_4

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bwd PROTEIN
(INOSAMINE-PHOSPHATE
AMIDINOTRANSFERASE)

(Streptomyces
griseus) 		no annotation 4 LEU A 124
CYH A 105
ALA A 333
CYH A 332
 None
 1.00A 1mz9D-1bwdA:
0.0		 1mz9D-1bwdA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		4 LEU A 200
VAL A 198
ALA A 190
CYH A 191
 None
 1.14A 1mz9D-1gjuA:
0.0		 1mz9D-1gjuA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imj CCG1-INTERACTING
FACTOR B

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 LEU A 155
VAL A 157
ALA A 186
CYH A 190
 None
 1.07A 1mz9D-1imjA:
0.0		 1mz9D-1imjA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jax CONSERVED
HYPOTHETICAL PROTEIN

(Archaeoglobus
fulgidus) 		PF03807
(F420_oxidored) 		4 LEU A 167
VAL A   3
CYH A  65
ALA A  62
 None
 1.03A 1mz9D-1jaxA:
0.0		 1mz9D-1jaxA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfi PHOSPHOGLUCOMUTASE 1

(Paramecium
tetraurelia) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A 415
VAL A 411
ALA A 311
CYH A 307
 None
 1.05A 1mz9D-1kfiA:
0.0		 1mz9D-1kfiA:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 250
VAL A 255
CYH A 257
ALA A 181
 None
 1.19A 1mz9D-1kolA:
0.0		 1mz9D-1kolA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 LEU A 215
VAL A 284
ALA A 279
CYH A 280
 None
 1.12A 1mz9D-1lrkA:
0.0		 1mz9D-1lrkA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5n 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE

(Acinetobacter
calcoaceticus) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 LEU A 376
VAL A 389
ALA A 396
CYH A 393
 None
 1.00A 1mz9D-1q5nA:
0.5		 1mz9D-1q5nA:
6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5z MAJOR NAD(P)H-FLAVIN
OXIDOREDUCTASE

(Aliivibrio
fischeri) 		PF00881
(Nitroreductase) 		4 LEU A  85
VAL A  83
ALA A  79
CYH A  80
 None
 1.14A 1mz9D-1v5zA:
undetectable		 1mz9D-1v5zA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfy 3-HYDROXYANTHRANILAT
E-3,4-DIOXYGENASE

(Cupriavidus
metallidurans) 		PF06052
(3-HAO) 		4 VAL A 132
CYH A 125
ALA A 127
CYH A 128
 None
FE  A 301 (-2.4A)
FE  A 301 ( 4.7A)
FE  A 301 (-2.2A)
 1.12A 1mz9D-1yfyA:
undetectable		 1mz9D-1yfyA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zmr PHOSPHOGLYCERATE
KINASE

(Escherichia
coli) 		PF00162
(PGK) 		4 LEU A  11
VAL A  16
CYH A 133
ALA A 130
 None
 0.86A 1mz9D-1zmrA:
undetectable		 1mz9D-1zmrA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2af4 PHOSPHATE
ACETYLTRANSFERASE

(Methanosarcina
thermophila) 		PF01515
(PTA_PTB) 		4 LEU C 197
VAL C 326
CYH C 325
ALA C  42
 None
 0.95A 1mz9D-2af4C:
undetectable		 1mz9D-2af4C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7h HEMOGLOBIN ALPHA
CHAIN
HEMOGLOBIN BETA
CHAIN

(Cerdocyon thous) 		PF00042
(Globin) 		4 LEU B 105
VAL B 109
CYH B 112
ALA A 110
 None
 1.13A 1mz9D-2b7hB:
undetectable		 1mz9D-2b7hB:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		4 VAL A 328
CYH A 325
ALA A 322
CYH A 324
 None
 1.17A 1mz9D-2bnhA:
undetectable		 1mz9D-2bnhA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dhg TRNA SELENOCYSTEINE
ASSOCIATED PROTEIN
(SECP43)

(Homo sapiens) 		PF00076
(RRM_1) 		4 LEU A 103
VAL A 168
ALA A 153
CYH A 157
 None
 1.19A 1mz9D-2dhgA:
undetectable		 1mz9D-2dhgA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h21 RIBULOSE-1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E

(Pisum sativum) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 LEU A 359
VAL A 400
ALA A 407
CYH A 404
 None
 1.03A 1mz9D-2h21A:
undetectable		 1mz9D-2h21A:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji4 PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE-ASSOCIATE
D PROTEIN 2

(Homo sapiens) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		4 LEU A  89
VAL A  93
CYH A  96
ALA A 101
 None
 1.14A 1mz9D-2ji4A:
undetectable		 1mz9D-2ji4A:
9.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jm1 TRANSCRIPTIONAL
REGULATOR ATRX

(Homo sapiens) 		no annotation 4 VAL A 178
CYH A 171
ALA A 173
CYH A 174
 None
ZN  A   1 (-2.3A)
ZN  A   1 ( 4.5A)
ZN  A   1 (-2.3A)
 0.96A 1mz9D-2jm1A:
undetectable		 1mz9D-2jm1A:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le1 UNCHARACTERIZED
PROTEIN

(Thermobifida
fusca) 		PF10604
(Polyketide_cyc2) 		4 LEU A  93
VAL A  95
CYH A 103
ALA A  12
 None
 1.19A 1mz9D-2le1A:
undetectable		 1mz9D-2le1A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oer PROBABLE
TRANSCRIPTIONAL
REGULATOR

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N) 		4 LEU A 196
VAL A 108
ALA A 115
CYH A 112
 None
 1.07A 1mz9D-2oerA:
undetectable		 1mz9D-2oerA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		4 LEU A 162
VAL A 165
CYH A 168
ALA A  63
 None
 1.11A 1mz9D-2prdA:
undetectable		 1mz9D-2prdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q6z UROPORPHYRINOGEN
DECARBOXYLASE

(Homo sapiens) 		PF01208
(URO-D) 		4 LEU A 131
VAL A 134
ALA A  64
CYH A  65
 None
 0.96A 1mz9D-2q6zA:
undetectable		 1mz9D-2q6zA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq5 DEHYDROGENASE/REDUCT
ASE SDR FAMILY
MEMBER 1

(Homo sapiens) 		PF00106
(adh_short) 		4 LEU A  86
CYH A 188
ALA A 174
CYH A 177
 None
 1.09A 1mz9D-2qq5A:
undetectable		 1mz9D-2qq5A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6f EXCINUCLEASE ABC
SUBUNIT A

(Geobacillus
stearothermophilus) 		PF00005
(ABC_tran) 		4 LEU A 772
CYH A 736
ALA A 738
CYH A 739
 None
ZN  A1006 (-2.3A)
ZN  A1006 ( 4.2A)
ZN  A1006 (-2.3A)
 0.99A 1mz9D-2r6fA:
undetectable		 1mz9D-2r6fA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn2 CHROMOSOME
REPLICATION
INITIATION PROTEIN

(Geobacillus
kaustophilus) 		no annotation 4 LEU A  76
VAL A  72
CYH A  68
ALA A  58
 None
 1.19A 1mz9D-2vn2A:
undetectable		 1mz9D-2vn2A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A 233
CYH A 153
ALA A 198
CYH A 151
 None
 1.18A 1mz9D-2wbiA:
undetectable		 1mz9D-2wbiA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wex APOLIPOPROTEIN M

(Homo sapiens) 		PF11032
(ApoM) 		4 LEU A 175
VAL A 158
CYH A 157
CYH A 128
 None
 1.14A 1mz9D-2wexA:
undetectable		 1mz9D-2wexA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2

(Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		4 LEU A 107
VAL A 111
CYH A 114
ALA A 193
 None
 0.92A 1mz9D-2wnrA:
undetectable		 1mz9D-2wnrA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 LEU A 176
VAL A   7
CYH A   8
ALA A  67
 None
 1.07A 1mz9D-2x3eA:
undetectable		 1mz9D-2x3eA:
8.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xgo XCOGT

(Xanthomonas
campestris) 		PF13432
(TPR_16)
PF13844
(Glyco_transf_41) 		4 LEU A 495
VAL A 479
CYH A 477
ALA A 454
 None
 1.14A 1mz9D-2xgoA:
undetectable		 1mz9D-2xgoA:
6.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z01 PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Geobacillus
kaustophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 153
VAL A 123
ALA A 130
CYH A 127
 None
 1.17A 1mz9D-2z01A:
undetectable		 1mz9D-2z01A:
9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zfu CEREBRAL PROTEIN 1

(Homo sapiens) 		PF05148
(Methyltransf_8) 		4 VAL A 342
CYH A 332
ALA A 323
CYH A 320
 None
 1.12A 1mz9D-2zfuA:
undetectable		 1mz9D-2zfuA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9j MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE
7-INTERACTING
PROTEIN 2

(Mus musculus) 		PF00641
(zf-RanBP) 		4 LEU C 681
CYH C 670
ALA C 672
CYH C 673
 None
ZN  C   1 (-2.3A)
ZN  C   1 ( 4.6A)
ZN  C   1 (-2.3A)
 0.95A 1mz9D-3a9jC:
undetectable		 1mz9D-3a9jC:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b84 ZINC FINGER AND BTB
DOMAIN-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00651
(BTB) 		4 LEU A  16
VAL A  43
CYH A  46
CYH A  47
 None
UNK  A 900 ( 4.8A)
UNK  A 900 ( 1.7A)
UNK  A 901 ( 2.0A)
 1.10A 1mz9D-3b84A:
undetectable		 1mz9D-3b84A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A  59
VAL A  31
ALA A  38
CYH A  39
 None
 1.07A 1mz9D-3berA:
undetectable		 1mz9D-3berA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		4 LEU A 323
VAL A 306
CYH A 305
ALA A 303
 None
 1.18A 1mz9D-3bjeA:
undetectable		 1mz9D-3bjeA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g0q A/G-SPECIFIC ADENINE
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD)
PF14815
(NUDIX_4) 		4 LEU A  17
VAL A 210
CYH A 214
ALA A 216
 None
None
SF4  A 400 (-2.4A)
SF4  A 400 ( 4.7A)
 1.01A 1mz9D-3g0qA:
undetectable		 1mz9D-3g0qA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gj6 NUCLEAR PORE COMPLEX
PROTEIN NUP153

(Rattus
norvegicus) 		PF00641
(zf-RanBP) 		4 LEU B 686
CYH B 678
ALA B 680
CYH B 681
 None
ZN  B 300 (-2.6A)
ZN  B 300 ( 4.9A)
ZN  B 300 (-3.0A)
 0.85A 1mz9D-3gj6B:
undetectable		 1mz9D-3gj6B:
26.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		4 LEU A  15
CYH A 147
ALA A 149
CYH A 152
 None
ZN  A 201 ( 2.3A)
ZN  A 201 (-4.4A)
ZN  A 201 ( 2.3A)
 1.05A 1mz9D-3h0nA:
undetectable		 1mz9D-3h0nA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h15 PROTEIN MCM10
HOMOLOG

(Xenopus laevis) 		PF09329
(zf-primase) 		4 LEU A 317
CYH A 381
ALA A 383
CYH A 391
 None
ZN  A 500 (-2.4A)
ZN  A 500 ( 4.4A)
ZN  A 500 (-2.3A)
 1.10A 1mz9D-3h15A:
undetectable		 1mz9D-3h15A:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzd IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Cupriavidus
pinatubonensis) 		PF00465
(Fe-ADH) 		4 LEU A 158
VAL A  95
CYH A  42
ALA A  66
 None
 0.92A 1mz9D-3jzdA:
undetectable		 1mz9D-3jzdA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5n A/G-SPECIFIC ADENINE
DNA GLYCOSYLASE

(Homo sapiens) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 LEU X  86
VAL X 288
CYH X 292
ALA X 294
 None
None
SF4  X 400 (-2.2A)
SF4  X 400 ( 4.9A)
 1.06A 1mz9D-3n5nX:
undetectable		 1mz9D-3n5nX:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ngw MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
A (MOBA)

(Archaeoglobus
fulgidus) 		PF12804
(NTP_transf_3) 		4 LEU A 153
VAL A 158
CYH A 113
ALA A 111
 None
 0.82A 1mz9D-3ngwA:
undetectable		 1mz9D-3ngwA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nnq N-TERMINAL DOMAIN OF
MOLONEY MURINE
LEUKEMIA VIRUS
INTEGRASE

(Murine leukemia
virus) 		PF16721
(zf-H3C2) 		4 LEU A  88
CYH A  95
ALA A  97
CYH A  98
 None
ZN  A 201 (-2.2A)
ZN  A 201 ( 4.4A)
ZN  A 201 (-2.3A)
 0.72A 1mz9D-3nnqA:
undetectable		 1mz9D-3nnqA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzu PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT GAMMA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 VAL A 986
CYH A 936
ALA A 933
CYH A 932
 None
 1.11A 1mz9D-3nzuA:
undetectable		 1mz9D-3nzuA:
4.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p2a PUTATIVE
THIOREDOXIN-LIKE
PROTEIN

(Yersinia pestis) 		PF00085
(Thioredoxin) 		4 LEU A  14
CYH A   5
ALA A   7
CYH A   8
 None
ZN  A 151 (-2.3A)
ZN  A 151 ( 4.9A)
ZN  A 151 (-2.3A)
 1.16A 1mz9D-3p2aA:
undetectable		 1mz9D-3p2aA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uyk NDP-RHAMNOSYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		4 LEU A 304
CYH A 221
ALA A 255
CYH A 223
 None
 1.15A 1mz9D-3uykA:
undetectable		 1mz9D-3uykA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5k ZINC FINGER PROTEIN
SNAI1

(Homo sapiens) 		PF00096
(zf-C2H2)
PF13912
(zf-C2H2_6) 		4 LEU B 250
CYH B 238
ALA B 240
CYH B 241
 None
ZN  B 504 (-2.3A)
ZN  B 504 ( 4.3A)
ZN  B 504 (-2.2A)
 0.92A 1mz9D-3w5kB:
undetectable		 1mz9D-3w5kB:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axg EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 1.17A 1mz9D-4axgA:
undetectable		 1mz9D-4axgA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ay2 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX58

(Homo sapiens) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD) 		4 LEU A 496
CYH A 813
ALA A 815
CYH A 810
 None
ZN  A1923 (-2.1A)
ZN  A1923 ( 4.9A)
ZN  A1923 (-2.2A)
 0.90A 1mz9D-4ay2A:
undetectable		 1mz9D-4ay2A:
5.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b4c CHROMODOMAIN-HELICAS
E-DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 LEU A1168
VAL A1172
ALA A1179
CYH A1176
 None
 1.03A 1mz9D-4b4cA:
undetectable		 1mz9D-4b4cA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		4 LEU A 466
VAL A 232
CYH A 233
ALA A 264
 None
 1.14A 1mz9D-4c90A:
undetectable		 1mz9D-4c90A:
4.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		4 LEU H 187
VAL H 174
ALA H  77
CYH H 102
 None
 1.17A 1mz9D-4cr4H:
undetectable		 1mz9D-4cr4H:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		4 LEU A 195
VAL A 260
CYH A 264
ALA A 333
 None
 1.08A 1mz9D-4f3nA:
undetectable		 1mz9D-4f3nA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 858
CYH A 672
ALA A 666
CYH A 665
 None
 1.13A 1mz9D-4f9oA:
undetectable		 1mz9D-4f9oA:
4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 LEU C  95
VAL C 102
CYH C  50
ALA C 198
 None
 1.11A 1mz9D-4fzwC:
undetectable		 1mz9D-4fzwC:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glf RSFP

(uncultured
bacterium) 		PF01048
(PNP_UDP_1) 		4 LEU A 151
VAL A 147
CYH A 144
ALA A 269
 None
 0.94A 1mz9D-4glfA:
undetectable		 1mz9D-4glfA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ita SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Synechococcus
sp. PCC 7002) 		PF00171
(Aldedh) 		4 LEU A 437
VAL A  90
CYH A  91
ALA A  54
 None
 1.16A 1mz9D-4itaA:
undetectable		 1mz9D-4itaA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxj RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A

(Rickettsia
bellii) 		PF00398
(RrnaAD) 		4 LEU A 117
VAL A 126
ALA A 171
CYH A 167
 None
 1.12A 1mz9D-4jxjA:
undetectable		 1mz9D-4jxjA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k70 UL37

(Suid
alphaherpesvirus
1) 		PF03970
(Herpes_UL37_1) 		4 LEU A 414
VAL A 422
ALA A 327
CYH A 426
 None
 1.17A 1mz9D-4k70A:
undetectable		 1mz9D-4k70A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l15 FIDGETIN-LIKE
PROTEIN 1

(Caenorhabditis
elegans) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 LEU A 457
VAL A 369
CYH A 368
ALA A 316
 None
 1.00A 1mz9D-4l15A:
undetectable		 1mz9D-4l15A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lrs ACETALDEHYDE
DEHYDROGENASE

(Thermomonospora
curvata) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 LEU B 258
VAL B 279
ALA B 167
CYH B 227
 CL  B 402 (-4.8A)
CL  B 402 (-3.8A)
None
None
 1.14A 1mz9D-4lrsB:
undetectable		 1mz9D-4lrsB:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4k HYDROXYLAMINE
OXIDOREDUCTASE

(Candidatus
Kuenenia
stuttgartiensis) 		PF13447
(Multi-haem_cyto) 		4 VAL A 117
CYH A 116
ALA A 161
CYH A 160
 HEM  A 608 ( 4.8A)
HEM  A 607 (-1.7A)
HEM  A 607 (-3.9A)
HEM  A 608 ( 1.8A)
 1.04A 1mz9D-4n4kA:
undetectable		 1mz9D-4n4kA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 LEU A 342
CYH A 365
ALA A 367
CYH A 368
 None
ZN  A 501 (-2.4A)
ZN  A 501 ( 4.6A)
ZN  A 501 (-2.3A)
 1.04A 1mz9D-4nqyA:
undetectable		 1mz9D-4nqyA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nqy ISOPROPYLMALATE/CITR
AMALATE ISOMERASE
LARGE SUBUNIT

(Methanocaldococcus
jannaschii) 		PF00330
(Aconitase) 		4 LEU A 345
CYH A 365
ALA A 367
CYH A 368
 None
ZN  A 501 (-2.4A)
ZN  A 501 ( 4.6A)
ZN  A 501 (-2.3A)
 0.71A 1mz9D-4nqyA:
undetectable		 1mz9D-4nqyA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzg INTEGRASE P46

(Murine leukemia
virus) 		PF16721
(zf-H3C2) 		4 LEU A  88
CYH A  95
ALA A  97
CYH A  98
 None
ZN  A 201 (-2.2A)
ZN  A 201 ( 4.7A)
ZN  A 201 (-2.2A)
 0.64A 1mz9D-4nzgA:
undetectable		 1mz9D-4nzgA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		4 LEU A 293
VAL A 273
ALA A 280
CYH A 277
 None
 1.16A 1mz9D-4ofxA:
undetectable		 1mz9D-4ofxA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A 120
VAL A 125
CYH A 129
ALA A 160
 None
 1.15A 1mz9D-4perA:
undetectable		 1mz9D-4perA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		4 LEU A  64
VAL A  66
CYH A  67
ALA A  69
 None
 1.14A 1mz9D-4qdkA:
undetectable		 1mz9D-4qdkA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgi GLUTAMATE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A  30
VAL A  33
ALA A 419
CYH A 420
 None
 0.99A 1mz9D-4xgiA:
undetectable		 1mz9D-4xgiA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y1p 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfolobus
acidocaldarius) 		PF00180
(Iso_dh) 		4 VAL A 218
CYH A 167
ALA A 182
CYH A 185
 None
 1.19A 1mz9D-4y1pA:
undetectable		 1mz9D-4y1pA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		4 LEU A  10
VAL A  12
CYH A  13
ALA A  15
 None
 1.17A 1mz9D-4zhtA:
undetectable		 1mz9D-4zhtA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpx ATP-DEPENDENT
PROTEASE LON

(Thermococcus
onnurineus) 		PF01078
(Mg_chelatase)
PF13654
(AAA_32) 		4 LEU A 185
VAL A 286
CYH A 288
ALA A 261
 None
 1.08A 1mz9D-4zpxA:
undetectable		 1mz9D-4zpxA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Oryctolagus
cuniculus) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		4 LEU C 675
CYH C 571
ALA C 568
CYH C 567
 None
 0.84A 1mz9D-5a5tC:
undetectable		 1mz9D-5a5tC:
4.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b37 TRYPTOPHAN
DEHYDROGENASE

(Nostoc
punctiforme) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		4 LEU A 195
VAL A 174
ALA A 255
CYH A 233
 None
 1.14A 1mz9D-5b37A:
undetectable		 1mz9D-5b37A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bt8 PHOSPHOGLYCERATE
KINASE

(Acinetobacter
baumannii) 		PF00162
(PGK) 		4 LEU A  11
VAL A  16
CYH A 133
ALA A 130
 None
 0.85A 1mz9D-5bt8A:
undetectable		 1mz9D-5bt8A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czc MALONYL-COA-[ACYL-CA
RRIER-PROTEIN]
TRANSACYLASE

(Streptomyces
halstedii) 		no annotation 4 LEU A 280
VAL A 288
CYH A 289
ALA A 312
 None
 1.13A 1mz9D-5czcA:
undetectable		 1mz9D-5czcA:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5er3 SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13407
(Peripla_BP_4) 		4 LEU A  90
VAL A  88
ALA A  85
CYH A  86
 None
 1.14A 1mz9D-5er3A:
undetectable		 1mz9D-5er3A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5flz SPINDLE POLE BODY
COMPONENT SPC97

(Saccharomyces
cerevisiae) 		PF04130
(Spc97_Spc98) 		4 LEU A 390
VAL A 394
CYH A 397
ALA A 401
 None
 0.85A 1mz9D-5flzA:
undetectable		 1mz9D-5flzA:
5.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn3 PRESENILIN-1

(Homo sapiens) 		PF01080
(Presenilin) 		4 LEU B  85
VAL B  89
CYH B  92
ALA B 231
 None
 1.16A 1mz9D-5fn3B:
undetectable		 1mz9D-5fn3B:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g0f HDAC6

(Danio rerio) 		PF02148
(zf-UBP) 		4 VAL A1056
CYH A1049
ALA A1051
CYH A1052
 None
ZN  A2082 (-2.2A)
ZN  A2082 ( 4.3A)
ZN  A2082 (-2.4A)
 0.82A 1mz9D-5g0fA:
undetectable		 1mz9D-5g0fA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		4 LEU A1458
VAL A1478
CYH A1479
CYH A1481
 None
None
ZN  A1703 (-2.3A)
ZN  A1703 (-2.3A)
 1.00A 1mz9D-5gutA:
undetectable		 1mz9D-5gutA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikn THIOREDOXIN-1

(Escherichia
coli) 		PF00085
(Thioredoxin) 		4 LEU K  94
CYH K  35
ALA K  29
CYH K  32
 None
 1.04A 1mz9D-5iknK:
undetectable		 1mz9D-5iknK:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwx 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE

(Bacillus
subtilis) 		PF02542
(YgbB) 		4 LEU A  41
VAL A  45
ALA A  52
CYH A  49
 None
 1.13A 1mz9D-5iwxA:
undetectable		 1mz9D-5iwxA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ix1 MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Mus musculus) 		PF07496
(zf-CW)
PF13589
(HATPase_c_3) 		4 LEU A 422
CYH A 413
ALA A 415
CYH A 416
 None
ZN  A 501 (-2.1A)
ZN  A 501 ( 4.8A)
ZN  A 501 (-2.0A)
 1.13A 1mz9D-5ix1A:
undetectable		 1mz9D-5ix1A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kn8 ADENINE DNA
GLYCOSYLASE

(Geobacillus
stearothermophilus) 		PF00633
(HHH)
PF00730
(HhH-GPD) 		4 LEU A  17
VAL A 210
CYH A 214
ALA A 216
 None
None
SF4  A 301 (-2.3A)
SF4  A 301 ( 4.8A)
 1.00A 1mz9D-5kn8A:
undetectable		 1mz9D-5kn8A:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks1 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Vibrio
vulnificus) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 LEU A 379
VAL A 108
ALA A  89
CYH A  86
 None
 1.12A 1mz9D-5ks1A:
undetectable		 1mz9D-5ks1A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6s GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		4 LEU A 422
VAL A 417
ALA A 365
CYH A 382
 None
 1.10A 1mz9D-5l6sA:
undetectable		 1mz9D-5l6sA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		4 LEU A 185
VAL A 235
CYH A 234
ALA A 198
 None
 1.12A 1mz9D-5nlaA:
undetectable		 1mz9D-5nlaA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6c E3 UBIQUITIN-PROTEIN
LIGASE MYCBP2

(Homo sapiens) 		no annotation 4 LEU A4616
CYH A4579
ALA A4581
CYH A4582
 None
ZN  A4705 (-2.3A)
None
ZN  A4705 (-2.3A)
 1.15A 1mz9D-5o6cA:
undetectable		 1mz9D-5o6cA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc9 -

(-) 		no annotation 4 LEU A 429
VAL A 514
CYH A 513
ALA A 247
 None
None
None
79M  A 707 ( 3.7A)
 1.15A 1mz9D-5oc9A:
undetectable		 1mz9D-5oc9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svi MORC FAMILY CW-TYPE
ZINC FINGER PROTEIN
3

(Homo sapiens) 		PF07496
(zf-CW) 		4 LEU A 422
CYH A 413
ALA A 415
CYH A 416
 None
ZN  A 501 (-2.3A)
ZN  A 501 ( 4.8A)
ZN  A 501 (-2.3A)
 1.19A 1mz9D-5sviA:
undetectable		 1mz9D-5sviA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t47 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Drosophila
melanogaster) 		PF01652
(IF4E) 		4 LEU A 161
VAL A 165
CYH A 168
ALA A 173
 None
 1.10A 1mz9D-5t47A:
undetectable		 1mz9D-5t47A:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 4 LEU A 183
VAL A  13
ALA A  67
CYH A  16
 None
 1.17A 1mz9D-5wgcA:
undetectable		 1mz9D-5wgcA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyb PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE

(Pseudomonas
aeruginosa) 		no annotation 4 LEU B  55
CYH B 131
ALA B 128
CYH B 127
 None
 0.99A 1mz9D-5wybB:
undetectable		 1mz9D-5wybB:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 LEU D 800
VAL D 803
ALA D 809
CYH D 810
 None
 0.91A 1mz9D-5xbkD:
undetectable		 1mz9D-5xbkD:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE
SUBUNIT ABC10-ALPHA

(Komagataella
phaffii) 		PF03604
(DNA_RNApol_7kD) 		4 LEU L  42
CYH L  33
ALA L  35
CYH L  36
 None
ZN  L 101 (-2.6A)
None
ZN  L 101 (-2.4A)
 0.95A 1mz9D-5xogL:
undetectable		 1mz9D-5xogL:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yje PROTEIN HIRA

(Homo sapiens) 		no annotation 4 LEU A 768
VAL A 759
CYH A 749
ALA A 742
 None
 1.07A 1mz9D-5yjeA:
undetectable		 1mz9D-5yjeA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c49 ALCOHOL
DEHYDROGENASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A 237
VAL A 173
CYH A 194
ALA A 169
 None
 1.12A 1mz9D-6c49A:
undetectable		 1mz9D-6c49A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 5 LEU A 241
VAL A 184
CYH A 211
ALA A 175
CYH A 178
 None
 1.44A 1mz9D-6c9bA:
undetectable		 1mz9D-6c9bA:
22.50