SIMILAR PATTERNS OF AMINO ACIDS FOR 1MZ9_A_VDYA1002_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1avy FIBRITIN

(Escherichia
virus T4) 		PF07921
(Fibritin_C) 		3 ILE A 443
LEU A 446
VAL A 450
 None
 0.44A 1mz9B-1avyA:
2.1		 1mz9B-1avyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 ILE A 377
LEU A 380
VAL A 384
 None
 0.39A 1mz9B-1cbgA:
undetectable		 1mz9B-1cbgA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cnt CILIARY NEUROTROPHIC
FACTOR

(Homo sapiens) 		PF01110
(CNTF) 		3 ILE 1 109
LEU 1 112
VAL 1 116
 None
 0.16A 1mz9B-1cnt1:
undetectable		 1mz9B-1cnt1:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN

(Canavalia
ensiformis) 		no annotation 3 ILE X 268
LEU X 283
VAL Y 365
 None
 0.42A 1mz9B-1dgrX:
undetectable		 1mz9B-1dgrX:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkr PHOSPHORIBOSYL
PYROPHOSPHATE
SYNTHETASE

(Bacillus
subtilis) 		PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth) 		3 ILE A  72
LEU A  75
VAL A  79
 None
 0.23A 1mz9B-1dkrA:
undetectable		 1mz9B-1dkrA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1em9 GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 3 ILE A  19
LEU A  22
VAL A  26
 None
 0.37A 1mz9B-1em9A:
0.0		 1mz9B-1em9A:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f51 SPORULATION
INITIATION
PHOSPHOTRANSFERASE F

(Bacillus
subtilis) 		PF00072
(Response_reg) 		3 ILE E1215
LEU E1218
VAL E1222
 None
 0.43A 1mz9B-1f51E:
undetectable		 1mz9B-1f51E:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		3 ILE A 160
LEU A 163
VAL A 167
 None
 0.50A 1mz9B-1g8pA:
0.0		 1mz9B-1g8pA:
7.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl2 SYNTAXIN 8

(Rattus
norvegicus) 		no annotation 3 ILE D 183
LEU D 186
VAL D 190
 None
 0.49A 1mz9B-1gl2D:
4.5		 1mz9B-1gl2D:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		3 ILE A 401
LEU A 404
VAL A 408
 None
 0.38A 1mz9B-1gqrA:
undetectable		 1mz9B-1gqrA:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		3 ILE A 177
LEU A 180
VAL A 184
 None
 0.29A 1mz9B-1gsqA:
undetectable		 1mz9B-1gsqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		3 ILE A 162
LEU A 165
VAL A 169
 None
 0.40A 1mz9B-1gxsA:
undetectable		 1mz9B-1gxsA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htm HEMAGGLUTININ HA2
CHAIN

(uncultured beta
proteobacterium
UMTRA-608) 		PF00509
(Hemagglutinin) 		3 ILE B  77
LEU B  80
VAL B  84
 None
 0.30A 1mz9B-1htmB:
2.6		 1mz9B-1htmB:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k66 PHYTOCHROME RESPONSE
REGULATOR RCPB

(Tolypothrix sp.
PCC 7601) 		PF00072
(Response_reg) 		3 ILE A 125
LEU A 128
VAL A 132
 None
 0.44A 1mz9B-1k66A:
undetectable		 1mz9B-1k66A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		3 ILE A 184
LEU A 187
VAL A 191
 None
 0.46A 1mz9B-1kxhA:
undetectable		 1mz9B-1kxhA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lq2 BETA-D-GLUCAN
GLUCOHYDROLASE
ISOENZYME EXO1

(Hordeum vulgare) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 ILE A 325
LEU A 328
VAL A 332
 None
 0.41A 1mz9B-1lq2A:
undetectable		 1mz9B-1lq2A:
6.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN ALPHA
SUBUNIT

(Gallus gallus) 		PF08702
(Fib_alpha) 		3 ILE A 120
LEU A 123
VAL A 127
 None
 0.37A 1mz9B-1m1jA:
4.5		 1mz9B-1m1jA:
7.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4x PBCV-1 VIRUS CAPSID

(Paramecium
bursaria
Chlorella virus
1) 		PF04451
(Capsid_NCLDV)
PF16903
(Capsid_N) 		3 ILE A 152
LEU A 151
VAL A  72
 None
 0.45A 1mz9B-1m4xA:
undetectable		 1mz9B-1m4xA:
6.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6j TRIOSEPHOSPHATE
ISOMERASE

(Entamoeba
histolytica) 		PF00121
(TIM) 		3 ILE A  21
LEU A  24
VAL A  28
 None
 0.29A 1mz9B-1m6jA:
undetectable		 1mz9B-1m6jA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mql HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ILE B  77
LEU B  80
VAL B  84
 None
 0.40A 1mz9B-1mqlB:
undetectable		 1mz9B-1mqlB:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 ILE A 364
LEU A 367
VAL A 371
 None
 0.27A 1mz9B-1mu2A:
undetectable		 1mz9B-1mu2A:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 ILE B 364
LEU B 367
VAL B 371
 None
 0.47A 1mz9B-1mu2B:
undetectable		 1mz9B-1mu2B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nav HORMONE RECEPTOR
ALPHA 1, THRA1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE A 258
LEU A 261
VAL A 265
 None
 0.35A 1mz9B-1navA:
undetectable		 1mz9B-1navA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ndf CARNITINE
ACETYLTRANSFERASE

(Mus musculus) 		PF00755
(Carn_acyltransf) 		3 ILE A 351
LEU A 354
VAL A 358
 None
 0.49A 1mz9B-1ndfA:
undetectable		 1mz9B-1ndfA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa) 		PF05184
(SapB_1) 		3 ILE A  11
LEU A  14
VAL A  18
 None
 0.33A 1mz9B-1nklA:
undetectable		 1mz9B-1nklA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkz LIGHT-HARVESTING
PROTEIN B-800/850,
ALPHA CHAIN

(Rhodoblastus
acidophilus) 		PF00556
(LHC) 		3 ILE A  16
LEU A  19
VAL A  23
 None
None
RG1  B 401 ( 4.5A)
 0.21A 1mz9B-1nkzA:
2.8		 1mz9B-1nkzA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5w AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Rattus
norvegicus) 		PF01593
(Amino_oxidase) 		3 ILE A 373
LEU A 376
VAL A 380
 None
 0.27A 1mz9B-1o5wA:
undetectable		 1mz9B-1o5wA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ons CHAPERONE PROTEIN
HCHA

(Escherichia
coli) 		no annotation 3 ILE A  96
LEU A 132
VAL A 136
 None
 0.46A 1mz9B-1onsA:
undetectable		 1mz9B-1onsA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oy1 PUTATIVE SIGMA
CROSS-REACTING
PROTEIN 27A

(Escherichia
coli) 		no annotation 3 ILE A 208
LEU A 211
VAL A 215
 None
 0.34A 1mz9B-1oy1A:
undetectable		 1mz9B-1oy1A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7b INTEGRAL MEMBRANE
CHANNEL AND
CYTOSOLIC DOMAINS

(Burkholderia
pseudomallei) 		PF01007
(IRK) 		3 ILE A 126
LEU A 129
VAL A 133
 None
 0.36A 1mz9B-1p7bA:
undetectable		 1mz9B-1p7bA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7n GAG POLYPROTEIN
CAPSID PROTEIN P27

(Rous sarcoma
virus) 		no annotation 3 ILE A  19
LEU A  22
VAL A  26
 None
 0.24A 1mz9B-1p7nA:
undetectable		 1mz9B-1p7nA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pdu NUCLEAR HORMONE
RECEPTOR HR38

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		3 ILE A 485
LEU A 488
VAL A 492
 None
 0.26A 1mz9B-1pduA:
undetectable		 1mz9B-1pduA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgj 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		3 ILE A 326
LEU A 329
VAL A 333
 None
 0.20A 1mz9B-1pgjA:
undetectable		 1mz9B-1pgjA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvj PYROGENIC EXOTOXIN B

(Streptococcus
pyogenes) 		PF01640
(Peptidase_C10)
PF13734
(Inhibitor_I69) 		3 ILE A 261
LEU A 264
VAL A 268
 None
 0.40A 1mz9B-1pvjA:
undetectable		 1mz9B-1pvjA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q4x THYROID HORMONE
RECEPTOR BETA-1

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 ILE A 312
LEU A 315
VAL A 319
 None
 0.31A 1mz9B-1q4xA:
undetectable		 1mz9B-1q4xA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		3 ILE A 175
LEU A 174
VAL A 127
 None
 0.37A 1mz9B-1q5aA:
undetectable		 1mz9B-1q5aA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q9j POLYKETIDE SYNTHASE
ASSOCIATED PROTEIN 5

(Mycobacterium
tuberculosis) 		PF00668
(Condensation)
PF16911
(PapA_C) 		3 ILE A 406
LEU A 409
VAL A 413
 None
 0.22A 1mz9B-1q9jA:
undetectable		 1mz9B-1q9jA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		3 ILE A 323
LEU A 326
VAL A 330
 None
 0.40A 1mz9B-1qhbA:
undetectable		 1mz9B-1qhbA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qi9 PROTEIN (VANADIUM
BROMOPEROXIDASE)

(Ascophyllum
nodosum) 		no annotation 3 ILE A 469
LEU A 472
VAL A 476
 None
 0.49A 1mz9B-1qi9A:
undetectable		 1mz9B-1qi9A:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmy PROTEASE

(Foot-and-mouth
disease virus) 		PF05408
(Peptidase_C28) 		3 ILE A  56
LEU A  59
VAL A  63
 None
 0.36A 1mz9B-1qmyA:
undetectable		 1mz9B-1qmyA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu1 PROTEIN (INFLUENZA
RECOMBINANT HA2
CHAIN)

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		3 ILE A  77
LEU A  80
VAL A  84
 None
 0.31A 1mz9B-1qu1A:
2.4		 1mz9B-1qu1A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4v HYPOTHETICAL PROTEIN
AQ_328

(Aquifex
aeolicus) 		PF09123
(DUF1931) 		3 ILE A  49
LEU A  52
VAL A  56
 None
 0.22A 1mz9B-1r4vA:
undetectable		 1mz9B-1r4vA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6e TYPEIII-SECRETED
PROTEIN EFFECTOR:
INVASION-ASSOCIATED
PROTEIN

(Salmonella
enterica) 		PF07487
(SopE_GEF) 		3 ILE A 137
LEU A 141
VAL A 161
 None
 0.47A 1mz9B-1r6eA:
undetectable		 1mz9B-1r6eA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snn 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Methanocaldococcus
jannaschii) 		PF00926
(DHBP_synthase) 		3 ILE A 123
LEU A 126
VAL A 130
 None
 0.28A 1mz9B-1snnA:
undetectable		 1mz9B-1snnA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ILE B 206
LEU B 209
VAL B 213
 None
 0.21A 1mz9B-1sxjB:
undetectable		 1mz9B-1sxjB:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ILE D 341
LEU D 344
VAL D 348
 None
 0.37A 1mz9B-1sxjD:
undetectable		 1mz9B-1sxjD:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2k TRANSCRIPTION FACTOR
AP-1

(Homo sapiens) 		PF00170
(bZIP_1) 		3 ILE C 277
LEU C 280
VAL C 284
 None
 0.22A 1mz9B-1t2kC:
4.0		 1mz9B-1t2kC:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 ILE B 430
LEU B 433
VAL B 437
 None
 0.33A 1mz9B-1t3qB:
undetectable		 1mz9B-1t3qB:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tbx HYPOTHETICAL 11.0
KDA PROTEIN

(Sulfolobus
spindle-shaped
virus 1) 		no annotation 3 ILE A  23
LEU A  67
VAL A  56
 None
 0.49A 1mz9B-1tbxA:
undetectable		 1mz9B-1tbxA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdf THIOREDOXIN
REDUCTASE

(Escherichia
coli) 		PF07992
(Pyr_redox_2) 		3 ILE A 187
LEU A 190
VAL A 194
 None
 0.28A 1mz9B-1tdfA:
undetectable		 1mz9B-1tdfA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ted PKS18

(Mycobacterium
tuberculosis) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 ILE A 353
LEU A 356
VAL A 360
 ILE  A 353 ( 0.7A)
LEU  A 356 ( 0.6A)
VAL  A 360 ( 0.6A)
 0.40A 1mz9B-1tedA:
undetectable		 1mz9B-1tedA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF03786
(UxuA) 		3 ILE A  47
LEU A  50
VAL A  54
 None
 0.26A 1mz9B-1tz9A:
undetectable		 1mz9B-1tz9A:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u10 PENICILLIN-INSENSITI
VE MUREIN
ENDOPEPTIDASE

(Escherichia
coli) 		PF03411
(Peptidase_M74) 		3 ILE A  78
LEU A  81
VAL A  85
 None
 0.32A 1mz9B-1u10A:
undetectable		 1mz9B-1u10A:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2l PEROXIDASE/CATALASE
HPI

(Escherichia
coli) 		PF00141
(peroxidase) 		3 ILE A 528
LEU A 531
VAL A 535
 None
 0.34A 1mz9B-1u2lA:
undetectable		 1mz9B-1u2lA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u6z EXOPOLYPHOSPHATASE

(Escherichia
coli) 		PF02541
(Ppx-GppA) 		3 ILE A 436
LEU A 439
VAL A 443
 None
 0.33A 1mz9B-1u6zA:
undetectable		 1mz9B-1u6zA:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		3 ILE A 209
LEU A 212
VAL A 216
 None
 0.47A 1mz9B-1uazA:
undetectable		 1mz9B-1uazA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug0 SPLICING FACTOR 4

(Mus musculus) 		PF01805
(Surp) 		3 ILE A  31
LEU A  34
VAL A  38
 None
 0.38A 1mz9B-1ug0A:
undetectable		 1mz9B-1ug0A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ulz PYRUVATE CARBOXYLASE
N-TERMINAL DOMAIN

(Aquifex
aeolicus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		3 ILE A  65
LEU A  68
VAL A  72
 None
 0.46A 1mz9B-1ulzA:
undetectable		 1mz9B-1ulzA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uyv ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF01039
(Carboxyl_trans) 		3 ILE A2136
LEU A2139
VAL A2143
 None
 0.30A 1mz9B-1uyvA:
undetectable		 1mz9B-1uyvA:
5.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb5 TRANSLATION
INITIATION FACTOR
EIF-2B

(Pyrococcus
horikoshii) 		PF01008
(IF-2B) 		3 ILE A  48
LEU A  51
VAL A  55
 None
 0.39A 1mz9B-1vb5A:
undetectable		 1mz9B-1vb5A:
9.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		3 ILE A 112
LEU A 110
VAL A 108
 FAD  A 400 (-3.7A)
None
None
 0.44A 1mz9B-1vdcA:
undetectable		 1mz9B-1vdcA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vke CARBOXYMUCONOLACTONE
DECARBOXYLASE FAMILY
PROTEIN

(Thermotoga
maritima) 		PF02627
(CMD) 		3 ILE A  96
LEU A  99
VAL A 103
 None
 0.19A 1mz9B-1vkeA:
undetectable		 1mz9B-1vkeA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		3 ILE A  66
LEU A  69
VAL A  73
 None
 0.42A 1mz9B-1vmeA:
undetectable		 1mz9B-1vmeA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmu HEMOGLOBIN A AND D
BETA CHAIN

(Aldabrachelys
gigantea) 		PF00042
(Globin) 		3 ILE B 111
LEU B 110
VAL B  23
 None
 0.46A 1mz9B-1wmuB:
undetectable		 1mz9B-1wmuB:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x4p PUTATIVE SPLICING
FACTOR,
ARGININE/SERINE-RICH
14

(Homo sapiens) 		PF01805
(Surp) 		3 ILE A  11
LEU A  14
VAL A  18
 None
 0.47A 1mz9B-1x4pA:
undetectable		 1mz9B-1x4pA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x7h PUTATIVE KETOACYL
REDUCTASE

(Streptomyces
coelicolor) 		PF00106
(adh_short) 		3 ILE A  70
LEU A  73
VAL A  77
 None
 0.15A 1mz9B-1x7hA:
undetectable		 1mz9B-1x7hA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8x UBIQUITIN-CONJUGATIN
G ENZYME E2 M

(Homo sapiens) 		PF00179
(UQ_con) 		3 ILE A 114
LEU A 115
VAL A 110
 None
 0.24A 1mz9B-1y8xA:
undetectable		 1mz9B-1y8xA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 ILE A 619
LEU A 622
VAL A 626
 None
 0.27A 1mz9B-1ygpA:
undetectable		 1mz9B-1ygpA:
4.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt3 RIBONUCLEASE D

(Escherichia
coli) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 ILE A 310
LEU A 313
VAL A 317
 None
 0.24A 1mz9B-1yt3A:
undetectable		 1mz9B-1yt3A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yxb PHOSPHORIBOSYL-ATP
PYROPHOSPHATASE

(Streptomyces
coelicolor) 		PF01503
(PRA-PH) 		3 ILE A  65
LEU A  68
VAL A  72
 None
 0.19A 1mz9B-1yxbA:
undetectable		 1mz9B-1yxbA:
25.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5x ECDYSONE RECEPTOR
LIGAND BINDING
DOMAIN

(Bemisia tabaci) 		PF00104
(Hormone_recep) 		3 ILE E 354
LEU E 357
VAL E 361
 None
 0.38A 1mz9B-1z5xE:
undetectable		 1mz9B-1z5xE:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zk8 TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Bacillus cereus) 		PF13305
(WHG) 		3 ILE A 119
LEU A 122
VAL A 126
 None
 0.33A 1mz9B-1zk8A:
undetectable		 1mz9B-1zk8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3v SITE-SPECIFIC
RECOMBINASE INTI4

(Vibrio cholerae) 		PF00589
(Phage_integrase)
PF13495
(Phage_int_SAM_4) 		3 ILE A 111
LEU A 114
VAL A 118
 None
 0.40A 1mz9B-2a3vA:
undetectable		 1mz9B-2a3vA:
9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		3 ILE A  77
LEU A  80
VAL A  84
 None
 0.24A 1mz9B-2aazA:
undetectable		 1mz9B-2aazA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahz POTASSIUM CHANNEL
PROTEIN

(Bacillus cereus) 		PF07885
(Ion_trans_2) 		3 ILE A  51
LEU A  54
VAL A  58
 None
 0.39A 1mz9B-2ahzA:
undetectable		 1mz9B-2ahzA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2awa DNA POLYMERASE III,
BETA CHAIN

(Streptococcus
pneumoniae) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		3 ILE A 327
LEU A 292
VAL A 299
 None
 0.48A 1mz9B-2awaA:
undetectable		 1mz9B-2awaA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axp HYPOTHETICAL PROTEIN
BSU20280

(Bacillus
subtilis) 		PF02223
(Thymidylate_kin) 		3 ILE A 128
LEU A 131
VAL A 135
 None
 0.40A 1mz9B-2axpA:
undetectable		 1mz9B-2axpA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		3 ILE A 595
LEU A 598
VAL A 602
 None
 0.40A 1mz9B-2btvA:
undetectable		 1mz9B-2btvA:
4.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvm TOXIN B

(Clostridioides
difficile) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 ILE A 138
LEU A 141
VAL A 145
 None
 0.49A 1mz9B-2bvmA:
undetectable		 1mz9B-2bvmA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		3 ILE A 268
LEU A 283
VAL A 365
 None
 0.46A 1mz9B-2cavA:
undetectable		 1mz9B-2cavA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cff 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)
METHYLIDENEAMINO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Thermotoga
maritima) 		PF00977
(His_biosynth) 		3 ILE A  56
LEU A  52
VAL A  50
 None
 0.46A 1mz9B-2cffA:
undetectable		 1mz9B-2cffA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csd TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		3 ILE A 225
LEU A 228
VAL A 232
 None
 0.48A 1mz9B-2csdA:
undetectable		 1mz9B-2csdA:
6.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		3 ILE A 461
LEU A 464
VAL A 468
 None
 0.18A 1mz9B-2d1cA:
undetectable		 1mz9B-2d1cA:
7.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5z SPLICING FACTOR,
ARGININE/SERINE-RICH
8

(Homo sapiens) 		PF01805
(Surp) 		3 ILE A  28
LEU A  31
VAL A  35
 None
 0.35A 1mz9B-2e5zA:
undetectable		 1mz9B-2e5zA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e87 HYPOTHETICAL PROTEIN
PH1320

(Pyrococcus
horikoshii) 		PF06858
(NOG1) 		3 ILE A 298
LEU A 301
VAL A 305
 None
 0.27A 1mz9B-2e87A:
undetectable		 1mz9B-2e87A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ekc TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Aquifex
aeolicus) 		PF00290
(Trp_syntA) 		3 ILE A 246
LEU A 249
VAL A 253
 None
 0.46A 1mz9B-2ekcA:
undetectable		 1mz9B-2ekcA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ep5 350AA LONG
HYPOTHETICAL
ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 ILE A 336
LEU A 339
VAL A 343
 None
 0.42A 1mz9B-2ep5A:
undetectable		 1mz9B-2ep5A:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		3 ILE A 104
LEU A 107
VAL A 111
 None
 0.47A 1mz9B-2f22A:
undetectable		 1mz9B-2f22A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f57 SERINE/THREONINE-PRO
TEIN KINASE PAK 7

(Homo sapiens) 		PF00069
(Pkinase) 		3 ILE A 626
LEU A 629
VAL A 633
 None
 0.49A 1mz9B-2f57A:
undetectable		 1mz9B-2f57A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhg PROTEASOME, BETA
SUBUNIT

(Mycobacterium
tuberculosis) 		no annotation 3 ILE H 380
LEU H 383
VAL H 387
 None
 0.35A 1mz9B-2fhgH:
undetectable		 1mz9B-2fhgH:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fno AGR_PAT_752P

(Agrobacterium
fabrum) 		no annotation 3 ILE A 194
LEU A 197
VAL A 201
 None
None
SCN  A 238 ( 4.4A)
 0.45A 1mz9B-2fnoA:
undetectable		 1mz9B-2fnoA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fu2 HYPOTHETICAL PROTEIN
SPY2152

(Streptococcus
pyogenes) 		PF08951
(EntA_Immun) 		3 ILE A  69
LEU A  72
VAL A  76
 None
 0.36A 1mz9B-2fu2A:
undetectable		 1mz9B-2fu2A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g5x RIBOSOME-INACTIVATIN
G PROTEIN

(Silene
chalcedonica) 		PF00161
(RIP) 		3 ILE A  59
LEU A  50
VAL A   6
 None
 0.50A 1mz9B-2g5xA:
undetectable		 1mz9B-2g5xA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		3 ILE A 356
LEU A 359
VAL A 363
 None
 0.27A 1mz9B-2gjxA:
undetectable		 1mz9B-2gjxA:
7.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT ALPHA

(Homo sapiens) 		no annotation 3 ILE I 356
LEU I 359
VAL I 363
 None
 0.32A 1mz9B-2gk1I:
undetectable		 1mz9B-2gk1I:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsl HYPOTHETICAL PROTEIN

(Fusobacterium
nucleatum) 		PF00636
(Ribonuclease_3) 		3 ILE A  41
LEU A  44
VAL A  48
 None
 0.48A 1mz9B-2gslA:
undetectable		 1mz9B-2gslA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwg 4-OXALOMESACONATE
HYDRATASE

(Rhodopseudomonas
palustris) 		PF04909
(Amidohydro_2) 		3 ILE A 125
LEU A 128
VAL A 132
 None
 0.44A 1mz9B-2gwgA:
undetectable		 1mz9B-2gwgA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h5j CASPASE-3, P17
SUBUNIT

(Homo sapiens) 		PF00656
(Peptidase_C14) 		3 ILE A  96
LEU A  99
VAL A 103
 None
 0.26A 1mz9B-2h5jA:
undetectable		 1mz9B-2h5jA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdn ELONGATION FACTOR
EF-TU

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 ILE B 363
LEU B 362
VAL B 360
 None
 0.44A 1mz9B-2hdnB:
undetectable		 1mz9B-2hdnB:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hor ALLIIN LYASE 1

(Allium sativum) 		PF04863
(EGF_alliinase)
PF04864
(Alliinase_C) 		3 ILE A 109
LEU A 112
VAL A 116
 None
 0.47A 1mz9B-2horA:
undetectable		 1mz9B-2horA:
7.47